Wim Robberecht

Wim Robberecht

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Wim Robberecht

Publications by authors named "Wim Robberecht"

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RNA toxicity in non-coding repeat expansion disorders.

EMBO J 2019 Nov 13:e101112. Epub 2019 Nov 13.

Department of Neurosciences, Experimental Neurology, Leuven Brain Institute (LBI), KU Leuven - University of Leuven, Leuven, Belgium.

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http://dx.doi.org/10.15252/embj.2018101112DOI Listing
November 2019

Lowering EphA4 Does Not Ameliorate Disease in a Mouse Model for Severe Spinal Muscular Atrophy.

Front Neurosci 2019 19;13:1233. Epub 2019 Nov 19.

Department of Neurosciences, Experimental Neurology and Leuven Brain Institute (LBI), KU Leuven - University of Leuven, Leuven, Belgium.

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http://dx.doi.org/10.3389/fnins.2019.01233DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6877733PMC
November 2019

Reducing EphA4 before disease onset does not affect survival in a mouse model of Amyotrophic Lateral Sclerosis.

Sci Rep 2019 Oct 1;9(1):14112. Epub 2019 Oct 1.

KU Leuven - University of Leuven, Department of Neurosciences, Experimental Neurology and Leuven Brain Institute (LBI), Leuven, Belgium.

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http://dx.doi.org/10.1038/s41598-019-50615-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6773754PMC
October 2019

Reduction of ephrin-A5 aggravates disease progression in amyotrophic lateral sclerosis.

Acta Neuropathol Commun 2019 Jul 12;7(1):114. Epub 2019 Jul 12.

Department of Neurosciences, Experimental Neurology and Leuven Brain Institute (LBI), KU Leuven - University of Leuven, Leuven, Belgium.

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http://dx.doi.org/10.1186/s40478-019-0759-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6626434PMC
July 2019

Heterozygous Deletion of EphrinA5 Does Not Improve Functional Recovery After Experimental Stroke.

Stroke 2019 Apr;50(4):e101

From the KU Leuven-University of Leuven, Department of Neurosciences, Experimental Neurology, and Leuven Brain Institute (LBI), Belgium (A.d.B., A.S., L.R., L.P., W.R., R.L.).

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http://dx.doi.org/10.1161/STROKEAHA.118.023857DOI Listing
April 2019

FUS-induced neurotoxicity in Drosophila is prevented by downregulating nucleocytoplasmic transport proteins.

Hum Mol Genet 2018 12;27(23):4103-4116

Department of Neurosciences, Experimental Neurology and Leuven Brain Institute (LBI), KU Leuven-University of Leuven, Leuven, Belgium.

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https://academic.oup.com/hmg/advance-article/doi/10.1093/hmg
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http://dx.doi.org/10.1093/hmg/ddy303DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6240733PMC
December 2018

Astrocyte-derived Jagged-1 mitigates deleterious Notch signaling in amyotrophic lateral sclerosis.

Neurobiol Dis 2018 11 26;119:26-40. Epub 2018 Jul 26.

KU Leuven - University of Leuven, Department of Neurosciences, Laboratory of Neurobiology and Experimental Neurology, and Leuven Brain Institute (LBI), Herestraat 49, B-3000 Leuven, Belgium; VIB, Center for Brain & Disease Research, Herestraat 49, B-3000 Leuven, Belgium; University Hospitals Leuven, Department of Neurology, Herestraat 49, B-3000 Leuven, Belgium. Electronic address:

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http://dx.doi.org/10.1016/j.nbd.2018.07.012DOI Listing
November 2018

Progranulin reduces insoluble TDP-43 levels, slows down axonal degeneration and prolongs survival in mutant TDP-43 mice.

Mol Neurodegener 2018 10 16;13(1):55. Epub 2018 Oct 16.

Department of Neurosciences, Experimental Neurology and Leuven Brain Institute (LBI), KU Leuven - University of Leuven, Leuven, Belgium.

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https://molecularneurodegeneration.biomedcentral.com/article
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http://dx.doi.org/10.1186/s13024-018-0288-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6192075PMC
October 2018

Conditional deletion of Id2 or Notch1 in oligodendrocyte progenitor cells does not ameliorate disease outcome in SOD1 mice.

Neurobiol Aging 2018 08 3;68:1-4. Epub 2018 Apr 3.

Department of Neurosciences, KU Leuven-University of Leuven, Experimental Neurology, Leuven, Belgium; VIB, Center for Brain & Disease Research, Laboratory of Neurobiology, Leuven, Belgium; Department of Neurology, University Hospitals Leuven, Leuven, Belgium. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S01974580183011
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http://dx.doi.org/10.1016/j.neurobiolaging.2018.03.026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5998381PMC
August 2018

Molecular Dissection of FUS Points at Synergistic Effect of Low-Complexity Domains in Toxicity.

Cell Rep 2018 07;24(3):529-537.e4

Experimental Neurology, Department of Neurosciences, and Leuven Brain Institute (LBI), KU Leuven-University of Leuven, 3000 Leuven, Belgium; Laboratory of Neurobiology, Center for Brain & Disease Research, VIB, 3000 Leuven, Belgium. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2018.06.070DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6077250PMC
July 2018

In Vivo Electrophysiological Measurement of Compound Muscle Action Potential from the Forelimbs in Mouse Models of Motor Neuron Degeneration.

J Vis Exp 2018 06 15(136). Epub 2018 Jun 15.

Department of Neurosciences, Experimental Neurology, KU Leuven - University of Leuven; Center for Brain & Disease Research, Laboratory of Neurobiology, VIB;

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http://dx.doi.org/10.3791/57741DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6101751PMC
June 2018

Inhibition of histone deacetylase 6 (HDAC6) protects against vincristine-induced peripheral neuropathies and inhibits tumor growth.

Neurobiol Dis 2018 03 29;111:59-69. Epub 2017 Nov 29.

KU Leuven - University of Leuven, Department of Neurosciences, Experimental Neurology, Leuven Research Institute for Neuroscience and Disease (LIND), Leuven, Belgium; VIB, Center for Brain & Disease Research, Laboratory of Neurobiology, Leuven, Belgium. Electronic address:

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http://dx.doi.org/10.1016/j.nbd.2017.11.011DOI Listing
March 2018

Genome-wide Analyses Identify KIF5A as a Novel ALS Gene.

Authors:
Aude Nicolas Kevin P Kenna Alan E Renton Nicola Ticozzi Faraz Faghri Ruth Chia Janice A Dominov Brendan J Kenna Mike A Nalls Pamela Keagle Alberto M Rivera Wouter van Rheenen Natalie A Murphy Joke J F A van Vugt Joshua T Geiger Rick A Van der Spek Hannah A Pliner Shankaracharya Bradley N Smith Giuseppe Marangi Simon D Topp Yevgeniya Abramzon Athina Soragia Gkazi John D Eicher Aoife Kenna Gabriele Mora Andrea Calvo Letizia Mazzini Nilo Riva Jessica Mandrioli Claudia Caponnetto Stefania Battistini Paolo Volanti Vincenzo La Bella Francesca L Conforti Giuseppe Borghero Sonia Messina Isabella L Simone Francesca Trojsi Fabrizio Salvi Francesco O Logullo Sandra D'Alfonso Lucia Corrado Margherita Capasso Luigi Ferrucci Cristiane de Araujo Martins Moreno Sitharthan Kamalakaran David B Goldstein Aaron D Gitler Tim Harris Richard M Myers Hemali Phatnani Rajeeva Lochan Musunuri Uday Shankar Evani Avinash Abhyankar Michael C Zody Julia Kaye Steven Finkbeiner Stacia K Wyman Alex LeNail Leandro Lima Ernest Fraenkel Clive N Svendsen Leslie M Thompson Jennifer E Van Eyk James D Berry Timothy M Miller Stephen J Kolb Merit Cudkowicz Emily Baxi Michael Benatar J Paul Taylor Evadnie Rampersaud Gang Wu Joanne Wuu Giuseppe Lauria Federico Verde Isabella Fogh Cinzia Tiloca Giacomo P Comi Gianni Sorarù Cristina Cereda Philippe Corcia Hannu Laaksovirta Liisa Myllykangas Lilja Jansson Miko Valori John Ealing Hisham Hamdalla Sara Rollinson Stuart Pickering-Brown Richard W Orrell Katie C Sidle Andrea Malaspina John Hardy Andrew B Singleton Janel O Johnson Sampath Arepalli Peter C Sapp Diane McKenna-Yasek Meraida Polak Seneshaw Asress Safa Al-Sarraj Andrew King Claire Troakes Caroline Vance Jacqueline de Belleroche Frank Baas Anneloor L M A Ten Asbroek José Luis Muñoz-Blanco Dena G Hernandez Jinhui Ding J Raphael Gibbs Sonja W Scholz Mary Kay Floeter Roy H Campbell Francesco Landi Robert Bowser Stefan M Pulst John M Ravits Daniel J L MacGowan Janine Kirby Erik P Pioro Roger Pamphlett James Broach Glenn Gerhard Travis L Dunckley Christopher B Brady Neil W Kowall Juan C Troncoso Isabelle Le Ber Kevin Mouzat Serge Lumbroso Terry D Heiman-Patterson Freya Kamel Ludo Van Den Bosch Robert H Baloh Tim M Strom Thomas Meitinger Aleksey Shatunov Kristel R Van Eijk Mamede de Carvalho Maarten Kooyman Bas Middelkoop Matthieu Moisse Russell L McLaughlin Michael A Van Es Markus Weber Kevin B Boylan Marka Van Blitterswijk Rosa Rademakers Karen E Morrison A Nazli Basak Jesús S Mora Vivian E Drory Pamela J Shaw Martin R Turner Kevin Talbot Orla Hardiman Kelly L Williams Jennifer A Fifita Garth A Nicholson Ian P Blair Guy A Rouleau Jesús Esteban-Pérez Alberto García-Redondo Ammar Al-Chalabi Ekaterina Rogaeva Lorne Zinman Lyle W Ostrow Nicholas J Maragakis Jeffrey D Rothstein Zachary Simmons Johnathan Cooper-Knock Alexis Brice Stephen A Goutman Eva L Feldman Summer B Gibson Franco Taroni Antonia Ratti Cinzia Gellera Philip Van Damme Wim Robberecht Pietro Fratta Mario Sabatelli Christian Lunetta Albert C Ludolph Peter M Andersen Jochen H Weishaupt William Camu John Q Trojanowski Vivianna M Van Deerlin Robert H Brown Leonard H van den Berg Jan H Veldink Matthew B Harms Jonathan D Glass David J Stone Pentti Tienari Vincenzo Silani Adriano Chiò Christopher E Shaw Bryan J Traynor John E Landers

Neuron 2018 03;97(6):1268-1283.e6

Department of Neurology, University of Massachusetts Medical School, Worcester, MA 01605, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neuron.2018.02.027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5867896PMC
March 2018

Amyotrophic lateral sclerosis.

Nat Rev Dis Primers 2017 Oct 5;3:17071. Epub 2017 Oct 5.

Department of Neurology, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands.

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http://dx.doi.org/10.1038/nrdp.2017.71DOI Listing
October 2017

Progranulin functions as a cathepsin D chaperone to stimulate axonal outgrowth in vivo.

Hum Mol Genet 2017 08;26(15):2850-2863

Department of Neurosciences, Experimental Neurology and Leuven Institute for Neuroscience and Disease (LIND), KU Leuven - University of Leuven, B-3000 Leuven, Belgium.

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http://dx.doi.org/10.1093/hmg/ddx162DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5886064PMC
August 2017

Identification and characterization of Nanobodies targeting the EphA4 receptor.

J Biol Chem 2017 07 19;292(27):11452-11465. Epub 2017 May 19.

From the KU Leuven-University of Leuven, Department of Neurosciences, Experimental Neurology and Leuven Research Institute for Neuroscience and Disease (LIND), 3000 Leuven, Belgium,

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http://dx.doi.org/10.1074/jbc.M116.774141DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5500810PMC
July 2017

Modelling amyotrophic lateral sclerosis: progress and possibilities.

Dis Model Mech 2017 05;10(5):537-549

KU Leuven, University of Leuven, Department of Neurosciences, Experimental Neurology, and Leuven Research Institute for Neuroscience and Disease (LIND), B-3000 Leuven, Belgium

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http://dx.doi.org/10.1242/dmm.029058DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5451175PMC
May 2017

Development of Improved HDAC6 Inhibitors as Pharmacological Therapy for Axonal Charcot-Marie-Tooth Disease.

Neurotherapeutics 2017 04;14(2):417-428

KU Leuven, Department of Neurosciences, Experimental Neurology and Leuven Research Institute for Neuroscience and Disease (LIND), University of Leuven, B-3000, Leuven, Belgium.

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http://dx.doi.org/10.1007/s13311-016-0501-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5398982PMC
April 2017

TBK1 Mutation Spectrum in an Extended European Patient Cohort with Frontotemporal Dementia and Amyotrophic Lateral Sclerosis.

Hum Mutat 2017 03 19;38(3):297-309. Epub 2017 Jan 19.

Center for Molecular Neurology, VIB, Antwerp, Belgium.

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http://dx.doi.org/10.1002/humu.23161DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5324646PMC
March 2017

Phase Separation of C9orf72 Dipeptide Repeats Perturbs Stress Granule Dynamics.

Mol Cell 2017 Mar;65(6):1044-1055.e5

Experimental Neurology and Leuven Research Institute for Neuroscience and Disease (LIND), Department of Neurosciences, KU Leuven - University of Leuven, 3000 Leuven, Belgium; Laboratory of Neurobiology, VIB, Center for Brain and Disease Research, 3000 Leuven, Belgium. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2017.02.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5364369PMC
March 2017

NEK1 variants confer susceptibility to amyotrophic lateral sclerosis.

Nat Genet 2016 09 25;48(9):1037-42. Epub 2016 Jul 25.

Department of Neurology, University of Massachusetts Medical School, Worcester, Massachusetts, USA.

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http://dx.doi.org/10.1038/ng.3626DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5560030PMC
September 2016

Genome-wide association analyses identify new risk variants and the genetic architecture of amyotrophic lateral sclerosis.

Authors:
Wouter van Rheenen Aleksey Shatunov Annelot M Dekker Russell L McLaughlin Frank P Diekstra Sara L Pulit Rick A A van der Spek Urmo Võsa Simone de Jong Matthew R Robinson Jian Yang Isabella Fogh Perry Tc van Doormaal Gijs H P Tazelaar Max Koppers Anna M Blokhuis William Sproviero Ashley R Jones Kevin P Kenna Kristel R van Eijk Oliver Harschnitz Raymond D Schellevis William J Brands Jelena Medic Androniki Menelaou Alice Vajda Nicola Ticozzi Kuang Lin Boris Rogelj Katarina Vrabec Metka Ravnik-Glavač Blaž Koritnik Janez Zidar Lea Leonardis Leja Dolenc Grošelj Stéphanie Millecamps François Salachas Vincent Meininger Mamede de Carvalho Susana Pinto Jesus S Mora Ricardo Rojas-García Meraida Polak Siddharthan Chandran Shuna Colville Robert Swingler Karen E Morrison Pamela J Shaw John Hardy Richard W Orrell Alan Pittman Katie Sidle Pietro Fratta Andrea Malaspina Simon Topp Susanne Petri Susanne Abdulla Carsten Drepper Michael Sendtner Thomas Meyer Roel A Ophoff Kim A Staats Martina Wiedau-Pazos Catherine Lomen-Hoerth Vivianna M Van Deerlin John Q Trojanowski Lauren Elman Leo McCluskey A Nazli Basak Ceren Tunca Hamid Hamzeiy Yesim Parman Thomas Meitinger Peter Lichtner Milena Radivojkov-Blagojevic Christian R Andres Cindy Maurel Gilbert Bensimon Bernhard Landwehrmeyer Alexis Brice Christine A M Payan Safaa Saker-Delye Alexandra Dürr Nicholas W Wood Lukas Tittmann Wolfgang Lieb Andre Franke Marcella Rietschel Sven Cichon Markus M Nöthen Philippe Amouyel Christophe Tzourio Jean-François Dartigues Andre G Uitterlinden Fernando Rivadeneira Karol Estrada Albert Hofman Charles Curtis Hylke M Blauw Anneke J van der Kooi Marianne de Visser An Goris Markus Weber Christopher E Shaw Bradley N Smith Orietta Pansarasa Cristina Cereda Roberto Del Bo Giacomo P Comi Sandra D'Alfonso Cinzia Bertolin Gianni Sorarù Letizia Mazzini Viviana Pensato Cinzia Gellera Cinzia Tiloca Antonia Ratti Andrea Calvo Cristina Moglia Maura Brunetti Simona Arcuti Rosa Capozzo Chiara Zecca Christian Lunetta Silvana Penco Nilo Riva Alessandro Padovani Massimiliano Filosto Bernard Muller Robbert Jan Stuit Ian Blair Katharine Zhang Emily P McCann Jennifer A Fifita Garth A Nicholson Dominic B Rowe Roger Pamphlett Matthew C Kiernan Julian Grosskreutz Otto W Witte Thomas Ringer Tino Prell Beatrice Stubendorff Ingo Kurth Christian A Hübner P Nigel Leigh Federico Casale Adriano Chio Ettore Beghi Elisabetta Pupillo Rosanna Tortelli Giancarlo Logroscino John Powell Albert C Ludolph Jochen H Weishaupt Wim Robberecht Philip Van Damme Lude Franke Tune H Pers Robert H Brown Jonathan D Glass John E Landers Orla Hardiman Peter M Andersen Philippe Corcia Patrick Vourc'h Vincenzo Silani Naomi R Wray Peter M Visscher Paul I W de Bakker Michael A van Es R Jeroen Pasterkamp Cathryn M Lewis Gerome Breen Ammar Al-Chalabi Leonard H van den Berg Jan H Veldink

Nat Genet 2016 09 25;48(9):1043-8. Epub 2016 Jul 25.

Department of Neurology, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, the Netherlands.

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http://dx.doi.org/10.1038/ng.3622DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5556360PMC
September 2016

A revision of the El Escorial criteria - 2015.

Amyotroph Lateral Scler Frontotemporal Degener 2015 29;16(5-6):291-2. Epub 2015 Jun 29.

g St. Joseph's Hospital and Medical Center , Phoenix , USA.

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http://dx.doi.org/10.3109/21678421.2015.1049183DOI Listing
August 2016

Prospective Validation of 18F-FDG Brain PET Discriminant Analysis Methods in the Diagnosis of Amyotrophic Lateral Sclerosis.

J Nucl Med 2016 Aug 3;57(8):1238-43. Epub 2016 Mar 3.

Department of Neurology, University Hospitals Leuven, Leuven, Belgium Department of Neurosciences, Experimental Neurology and Leuven Research Institute for Neuroscience and Disease (LIND), KU Leuven-University of Leuven, Leuven, Belgium; and Laboratory of Neurobiology, VIB, Vesalius Research Center, Leuven, Belgium.

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http://dx.doi.org/10.2967/jnumed.115.166272DOI Listing
August 2016

Genetic ablation of IP3 receptor 2 increases cytokines and decreases survival of SOD1G93A mice.

Hum Mol Genet 2016 08 4;25(16):3491-3499. Epub 2016 Jul 4.

KU Leuven - University of Leuven, Department of Neurosciences, Experimental Neurology and Leuven Research Institute for Neuroscience and Disease (LIND)

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http://dx.doi.org/10.1093/hmg/ddw190DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5179944PMC
August 2016

Noninvasive ventilation improves sleep in amyotrophic lateral sclerosis: a prospective polysomnographic study.

J Clin Sleep Med 2015 Apr 15;11(5):559-66. Epub 2015 Apr 15.

Leuven University Centre for Sleep/Wake Disorders, Department of Pulmonology, University Hospitals Leuven, Belgium.

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http://dx.doi.org/10.5664/jcsm.4704DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4410930PMC
April 2015

Cochlear supporting cell transdifferentiation and integration into hair cell layers by inhibition of ephrin-B2 signalling.

Nat Commun 2015 Apr 29;6:7017. Epub 2015 Apr 29.

GIGA-Neurosciences, Developmental Neurobiology Unit, University of Liège, C.H.U. B36, B-4000 Liège, Belgium.

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http://dx.doi.org/10.1038/ncomms8017DOI Listing
April 2015

The role of oligodendroglial dysfunction in amyotrophic lateral sclerosis.

Neurodegener Dis Manag 2014 ;4(3):223-39

KU Leuven - University of Leuven, Department of Neurosciences, Experimental Neurology and Leuven Research Institute for Neuroscience and Disease (LIND), B-3000 Leuven, Belgium.

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http://dx.doi.org/10.2217/nmt.14.21DOI Listing
March 2015

Translating biological findings into new treatment strategies for amyotrophic lateral sclerosis (ALS).

Exp Neurol 2014 Dec 11;262 Pt B:138-51. Epub 2014 Jul 11.

KU Leuven, Laboratory of Neurobiology and Leuven Research Institute for Neuroscience and Disease (LIND), Leuven, Belgium; VIB, Vesalius Research Center, Leuven, Belgium. Electronic address:

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http://dx.doi.org/10.1016/j.expneurol.2014.07.001DOI Listing
December 2014

The phenotypic variability of amyotrophic lateral sclerosis.

Nat Rev Neurol 2014 Nov 14;10(11):661-70. Epub 2014 Oct 14.

University of Leuven, Department of Neurosciences, Laboratory for Neurobiology, Vesalius Research Center, Box 912, B-3000 Leuven, Belgium.

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http://www.nature.com/articles/nrneurol.2014.184
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http://dx.doi.org/10.1038/nrneurol.2014.184DOI Listing
November 2014

Rare mutations in SQSTM1 modify susceptibility to frontotemporal lobar degeneration.

Acta Neuropathol 2014 Sep 5;128(3):397-410. Epub 2014 Jun 5.

Department of Molecular Genetics, VIB, Antwerp, Belgium.

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http://dx.doi.org/10.1007/s00401-014-1298-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4131163PMC
September 2014

Developments in treatments for amyotrophic lateral sclerosis via intracerebroventricular or intrathecal delivery.

Expert Opin Investig Drugs 2014 Jul 9;23(7):955-63. Epub 2014 May 9.

KU Leuven (University of Leuven), Department of Neurosciences, Experimental Neurology and Leuven Research Institute for Neuroscience and Disease (LIND) , Leuven , Belgium.

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https://www.tandfonline.com/doi/full/10.1517/13543784.2014.9
Publisher Site
http://dx.doi.org/10.1517/13543784.2014.912275DOI Listing
July 2014

Exome sequencing reveals HINT1 mutations as a cause of distal hereditary motor neuropathy.

Eur J Hum Genet 2014 Jun 9;22(6):847-50. Epub 2013 Oct 9.

1] Vesalius Research Center, VIB, Leuven, Belgium [2] Department of Experimental Neurology, Leuven Research Institute for Neurodegenerative Diseases (LIND), KU Leuven, Leuven, Belgium [3] Department of Neurology, University Hospital Leuven, Leuven, Belgium.

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http://dx.doi.org/10.1038/ejhg.2013.231DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4023208PMC
June 2014

Prevention of intestinal obstruction reveals progressive neurodegeneration in mutant TDP-43 (A315T) mice.

Mol Neurodegener 2014 Jun 17;9:24. Epub 2014 Jun 17.

KU Leuven - University of Leuven, Department of Neurosciences, Experimental Neurology and Leuven Research Institute for Neuroscience and Disease (LIND), Leuven, Belgium.

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http://molecularneurodegeneration.biomedcentral.com/articles
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http://dx.doi.org/10.1186/1750-1326-9-24DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4088917PMC
June 2014

Value of 18fluorodeoxyglucose-positron-emission tomography in amyotrophic lateral sclerosis: a prospective study.

JAMA Neurol 2014 May;71(5):553-61

KU Leuven, Department of Neurology, University Hospital Leuven, Leuven, Belgium3KU Leuven, Department of Neurosciences, Experimental Neurology, and Leuven Research Institute for Neuroscience and Disease (LIND), Leuven, Belgium4VIB, Vesalius Research Cente.

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http://dx.doi.org/10.1001/jamaneurol.2014.62DOI Listing
May 2014

Frequency of C9orf72 repeat expansions in amyotrophic lateral sclerosis: a Belgian cohort study.

Neurobiol Aging 2013 Dec 17;34(12):2890.e7-2890.e12. Epub 2013 Jul 17.

Department of Neurology, University of Leuven, Leuven, Belgium.

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http://dx.doi.org/10.1016/j.neurobiolaging.2013.06.009DOI Listing
December 2013

Genetic ablation of phospholipase C delta 1 increases survival in SOD1(G93A) mice.

Neurobiol Dis 2013 Dec 19;60:11-7. Epub 2013 Aug 19.

Laboratory of Neurobiology, Belgium; Leuven Research Institute of Neuroscience and Disease (LIND), KU Leuven, Belgium; Vesalius Research Center, VIB, Belgium. Electronic address:

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http://dx.doi.org/10.1016/j.nbd.2013.08.006DOI Listing
December 2013

Beta-2 microglobulin is important for disease progression in a murine model for amyotrophic lateral sclerosis.

Front Cell Neurosci 2013 10;7:249. Epub 2013 Dec 10.

KU Leuven Laboratory of Neurobiology and Leuven Research Institute for Neuroscience and Disease (LIND) Leuven, Belgium ; VIB Vesalius Research Center, KU Leuven Leuven, Belgium.

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http://dx.doi.org/10.3389/fncel.2013.00249DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3857886PMC
December 2013

The neurotrophic properties of progranulin depend on the granulin E domain but do not require sortilin binding.

Neurobiol Aging 2013 Nov 24;34(11):2541-7. Epub 2013 May 24.

Laboratory of Neurobiology, Vesalius Research Center, VIB, Leuven, Belgium.

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http://dx.doi.org/10.1016/j.neurobiolaging.2013.04.022DOI Listing
November 2013

Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis.

Authors:
Ashley H Beecham Nikolaos A Patsopoulos Dionysia K Xifara Mary F Davis Anu Kemppinen Chris Cotsapas Tejas S Shah Chris Spencer David Booth An Goris Annette Oturai Janna Saarela Bertrand Fontaine Bernhard Hemmer Claes Martin Frauke Zipp Sandra D'Alfonso Filippo Martinelli-Boneschi Bruce Taylor Hanne F Harbo Ingrid Kockum Jan Hillert Tomas Olsson Maria Ban Jorge R Oksenberg Rogier Hintzen Lisa F Barcellos Cristina Agliardi Lars Alfredsson Mehdi Alizadeh Carl Anderson Robert Andrews Helle Bach Søndergaard Amie Baker Gavin Band Sergio E Baranzini Nadia Barizzone Jeffrey Barrett Céline Bellenguez Laura Bergamaschi Luisa Bernardinelli Achim Berthele Viola Biberacher Thomas M C Binder Hannah Blackburn Izaura L Bomfim Paola Brambilla Simon Broadley Bruno Brochet Lou Brundin Dorothea Buck Helmut Butzkueven Stacy J Caillier William Camu Wassila Carpentier Paola Cavalla Elisabeth G Celius Irène Coman Giancarlo Comi Lucia Corrado Leentje Cosemans Isabelle Cournu-Rebeix Bruce A C Cree Daniele Cusi Vincent Damotte Gilles Defer Silvia R Delgado Panos Deloukas Alessia di Sapio Alexander T Dilthey Peter Donnelly Bénédicte Dubois Martin Duddy Sarah Edkins Irina Elovaara Federica Esposito Nikos Evangelou Barnaby Fiddes Judith Field Andre Franke Colin Freeman Irene Y Frohlich Daniela Galimberti Christian Gieger Pierre-Antoine Gourraud Christiane Graetz Andrew Graham Verena Grummel Clara Guaschino Athena Hadjixenofontos Hakon Hakonarson Christopher Halfpenny Gillian Hall Per Hall Anders Hamsten James Harley Timothy Harrower Clive Hawkins Garrett Hellenthal Charles Hillier Jeremy Hobart Muni Hoshi Sarah E Hunt Maja Jagodic Ilijas Jelčić Angela Jochim Brian Kendall Allan Kermode Trevor Kilpatrick Keijo Koivisto Ioanna Konidari Thomas Korn Helena Kronsbein Cordelia Langford Malin Larsson Mark Lathrop Christine Lebrun-Frenay Jeannette Lechner-Scott Michelle H Lee Maurizio A Leone Virpi Leppä Giuseppe Liberatore Benedicte A Lie Christina M Lill Magdalena Lindén Jenny Link Felix Luessi Jan Lycke Fabio Macciardi Satu Männistö Clara P Manrique Roland Martin Vittorio Martinelli Deborah Mason Gordon Mazibrada Cristin McCabe Inger-Lise Mero Julia Mescheriakova Loukas Moutsianas Kjell-Morten Myhr Guy Nagels Richard Nicholas Petra Nilsson Fredrik Piehl Matti Pirinen Siân E Price Hong Quach Mauri Reunanen Wim Robberecht Neil P Robertson Mariaemma Rodegher David Rog Marco Salvetti Nathalie C Schnetz-Boutaud Finn Sellebjerg Rebecca C Selter Catherine Schaefer Sandip Shaunak Ling Shen Simon Shields Volker Siffrin Mark Slee Per Soelberg Sorensen Melissa Sorosina Mireia Sospedra Anne Spurkland Amy Strange Emilie Sundqvist Vincent Thijs John Thorpe Anna Ticca Pentti Tienari Cornelia van Duijn Elizabeth M Visser Steve Vucic Helga Westerlind James S Wiley Alastair Wilkins James F Wilson Juliane Winkelmann John Zajicek Eva Zindler Jonathan L Haines Margaret A Pericak-Vance Adrian J Ivinson Graeme Stewart David Hafler Stephen L Hauser Alastair Compston Gil McVean Philip De Jager Stephen J Sawcer Jacob L McCauley

Nat Genet 2013 Nov 29;45(11):1353-60. Epub 2013 Sep 29.

1] John P. Hussman Institute for Human Genomics, University of Miami, Miller School of Medicine, Miami, Florida, USA. [2].

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http://dx.doi.org/10.1038/ng.2770DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3832895PMC
November 2013

Progranulin does not affect motor neuron degeneration in mutant SOD1 mice and rats.

Neurobiol Aging 2013 Oct 19;34(10):2302-3. Epub 2013 Apr 19.

Laboratory of Neurobiology, Experimental Neurology and Leuven Institute for Neurodegenerative Disorders (LIND) University of Leuven, Leuven, Belgium.

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http://dx.doi.org/10.1016/j.neurobiolaging.2013.03.027DOI Listing
October 2013

Clinical implications of recent breakthroughs in amyotrophic lateral sclerosis.

Curr Opin Neurol 2013 Oct;26(5):466-72

Laboratory of Neurobiology, Vesalius Research Center, VIB, University of Leuven, Leuven, Belgium.

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http://dx.doi.org/10.1097/WCO.0b013e328364c063DOI Listing
October 2013

Rapamycin increases survival in ALS mice lacking mature lymphocytes.

Mol Neurodegener 2013 Sep 11;8:31. Epub 2013 Sep 11.

Laboratory of Neurobiology, Vesalius Research Center, VIB, Leuven, Belgium.

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http://dx.doi.org/10.1186/1750-1326-8-31DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3847677PMC
September 2013

Modifying expression of EphA4 and its downstream targets improves functional recovery after stroke.

Hum Mol Genet 2013 Jun 14;22(11):2214-20. Epub 2013 Feb 14.

Laboratory of Neurobiology, Vesalius Research Center, VIB, Leuven, Belgium.

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http://dx.doi.org/10.1093/hmg/ddt073DOI Listing
June 2013

Hdac6 deletion delays disease progression in the SOD1G93A mouse model of ALS.

Hum Mol Genet 2013 May 30;22(9):1783-90. Epub 2013 Jan 30.

Experimental Neurology, Department of Neurosciences, Leuven Research Institute for Neuroscience and Disease (LIND), University of Leuven (KU Leuven), Leuven, Belgium.

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http://dx.doi.org/10.1093/hmg/ddt028DOI Listing
May 2013

The changing scene of amyotrophic lateral sclerosis.

Nat Rev Neurosci 2013 Apr 6;14(4):248-64. Epub 2013 Mar 6.

Laboratory of Neurobiology, VIB Vesalius Research Center, 3000 Leuven, Belgium.

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http://www.nature.com/articles/nrn3430
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http://dx.doi.org/10.1038/nrn3430DOI Listing
April 2013

Non-invasive ventilation in amyotrophic lateral sclerosis.

Amyotroph Lateral Scler Frontotemporal Degener 2013 Mar 4;14(2):85-95. Epub 2013 Jan 4.

Respiratory Division, University Hospital Leuven, Herestraat 49, Leuven, Belgium.

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http://dx.doi.org/10.3109/21678421.2012.745568DOI Listing
March 2013

Neuronal overexpression of IP₃ receptor 2 is detrimental in mutant SOD1 mice.

Biochem Biophys Res Commun 2012 Dec 3;429(3-4):210-3. Epub 2012 Nov 3.

Laboratory of Neurobiology and Leuven Research Institute for Neuroscience and Disease (LIND), KU Leuven, Belgium.

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http://dx.doi.org/10.1016/j.bbrc.2012.10.094DOI Listing
December 2012

UNC13A is a modifier of survival in amyotrophic lateral sclerosis.

Neurobiol Aging 2012 Mar 25;33(3):630.e3-8. Epub 2011 Nov 25.

Department of Neurology, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, 3584 CX, Utrecht, The Netherlands.

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http://dx.doi.org/10.1016/j.neurobiolaging.2011.10.029DOI Listing
March 2012

Modeling neurodegenerative diseases in zebrafish embryos.

Methods Mol Biol 2011 ;793:167-84

Laboratory of Neurobiology, Department of Neurology, K.U. Leuven, Leuven, Belgium.

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http://dx.doi.org/10.1007/978-1-61779-328-8_11DOI Listing
December 2011

Benefit of the Awaji diagnostic algorithm for amyotrophic lateral sclerosis: a prospective study.

Ann Neurol 2011 Jul 17;70(1):79-83. Epub 2011 Mar 17.

Neurology Department, University Hospitals Leuven, Leuven, Belgium.

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http://dx.doi.org/10.1002/ana.22380DOI Listing
July 2011

TNFRSF1A coding variants in multiple sclerosis.

J Neuroimmunol 2011 Jun 11;235(1-2):110-2. Epub 2011 May 11.

Laboratory for Neuroimmunology, Section of Experimental Neurology, Katholieke Universiteit Leuven, Herestraat 49 Bus 1022, 3000 Leuven, Belgium.

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http://dx.doi.org/10.1016/j.jneuroim.2011.04.005DOI Listing
June 2011

Neuroinflammation in amyotrophic lateral sclerosis: role of glial activation in motor neuron disease.

Lancet Neurol 2011 Mar;10(3):253-63

VIB Vesalius Research Center, Leuven, Belgium.

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http://dx.doi.org/10.1016/S1474-4422(11)70015-1DOI Listing
March 2011

Unilateral white matter involvement in Krabbe disease.

Arch Neurol 2011 Jan;68(1):130-1

Department of Neurology, University Hospitals Leuven, Leuven, Belgium.

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http://dx.doi.org/10.1001/archneurol.2010.331DOI Listing
January 2011