Publications by authors named "Wiltrud Richter"

100Publications

Significance of MEF2C and RUNX3 Regulation for Endochondral Differentiation of Human Mesenchymal Progenitor Cells.

Front Cell Dev Biol 2020 4;8:81. Epub 2020 Mar 4.

Research Center for Experimental Orthopaedics, Heidelberg University Hospital, Heidelberg, Germany.

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http://dx.doi.org/10.3389/fcell.2020.00081DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7064729PMC
March 2020

Chondral Differentiation of Induced Pluripotent Stem Cells Without Progression Into the Endochondral Pathway.

Front Cell Dev Biol 2019 1;7:270. Epub 2019 Nov 1.

Research Center for Experimental Orthopaedics, Center for Orthopaedics, Trauma Surgery and Paraplegiology, Heidelberg University Hospital, Heidelberg, Germany.

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http://dx.doi.org/10.3389/fcell.2019.00270DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6838640PMC
November 2019

The Role of Extracellular Matrix Expression, ERK1/2 Signaling and Cell Cohesiveness for Cartilage Yield from iPSCs.

Int J Mol Sci 2019 Sep 2;20(17). Epub 2019 Sep 2.

Research Center for Experimental Orthopaedics, Heidelberg University Hospital, Schlierbacher Landstr. 200a, 69118 Heidelberg, Germany.

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http://dx.doi.org/10.3390/ijms20174295DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6747490PMC
September 2019

Regulation of WNT5A and WNT11 during MSC in vitro chondrogenesis: WNT inhibition lowers BMP and hedgehog activity, and reduces hypertrophy.

Cell Mol Life Sci 2019 Oct 12;76(19):3875-3889. Epub 2019 Apr 12.

Research Center for Experimental Orthopaedics, Heidelberg University Hospital, Heidelberg, Germany.

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http://dx.doi.org/10.1007/s00018-019-03099-0DOI Listing
October 2019

Impact of c-MYC expression on proliferation, differentiation, and risk of neoplastic transformation of human mesenchymal stromal cells.

Stem Cell Res Ther 2019 03 5;10(1):73. Epub 2019 Mar 5.

Research Center for Experimental Orthopaedics, Center for Orthopaedics, Trauma Surgery and Paraplegiology, Heidelberg University Hospital, Schlierbacher Landstrasse 200a, 69118, Heidelberg, Germany.

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http://dx.doi.org/10.1186/s13287-019-1187-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6402108PMC
March 2019

Treatment of Focal Cartilage Defects in Minipigs with Zonal Chondrocyte/Mesenchymal Progenitor Cell Constructs.

Int J Mol Sci 2019 Feb 2;20(3). Epub 2019 Feb 2.

Center of Orthopaedic and Trauma Surgery/Spinal Cord Injury Center, Heidelberg University Hospital, Germany, Schlierbacher Landstr. 200a, 69118 Heidelberg, Germany.

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http://dx.doi.org/10.3390/ijms20030653DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6387191PMC
February 2019

StarPEG/heparin-hydrogel based in vivo engineering of stable bizonal cartilage with a calcified bottom layer.

Biofabrication 2018 10 30;11(1):015001. Epub 2018 Oct 30.

Research Centre for Experimental Orthopaedics, Heidelberg University Hospital, Heidelberg, Germany.

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http://dx.doi.org/10.1088/1758-5090/aae75aDOI Listing
October 2018

Stimulation of calvarial bone healing with human bone marrow stromal cells versus inhibition with adipose-tissue stromal cells on nanostructured β-TCP-collagen.

Acta Biomater 2018 08 20;76:135-145. Epub 2018 Jun 20.

Research Center for Experimental Orthopaedics, Heidelberg University Hospital, Schlierbacher Landstr. 200a, 69118 Heidelberg, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.actbio.2018.06.026DOI Listing
August 2018

Time-dependent contribution of BMP, FGF, IGF, and HH signaling to the proliferation of mesenchymal stroma cells during chondrogenesis.

J Cell Physiol 2018 11 1;233(11):8962-8970. Epub 2018 Jun 1.

Research Centre for Experimental Orthopedics, Orthopaedic University Hospital Heidelberg, Heidelberg, Germany.

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http://dx.doi.org/10.1002/jcp.26832DOI Listing
November 2018

The Radiation Resistance of Human Multipotent Mesenchymal Stromal Cells Is Independent of Their Tissue of Origin.

Int J Radiat Oncol Biol Phys 2018 04 9;100(5):1259-1269. Epub 2018 Jan 9.

Department of Radiation Oncology, Heidelberg University Hospital, Heidelberg, Germany; Department of Molecular and Radiation Oncology, German Cancer Research Center (DKFZ), Heidelberg, Germany. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S03603016183005
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http://dx.doi.org/10.1016/j.ijrobp.2018.01.015DOI Listing
April 2018

Extracellular matrix content and WNT/β-catenin levels of cartilage determine the chondrocyte response to compressive load.

Biochim Biophys Acta Mol Basis Dis 2018 Mar 19;1864(3):851-859. Epub 2017 Dec 19.

Research Centre for Experimental Orthopaedics, Orthopaedic University Hospital Heidelberg, Heidelberg, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.bbadis.2017.12.024DOI Listing
March 2018

Stimulation of a calcified cartilage connecting zone by GDF-5-augmented fibrin hydrogel in a novel layered ectopic in vivo model.

J Biomed Mater Res B Appl Biomater 2018 08 25;106(6):2214-2224. Epub 2017 Oct 25.

Research Center for Experimental Orthopaedics, Heidelberg University Hospital, 69118, Heidelberg, Germany.

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http://doi.wiley.com/10.1002/jbm.b.34027
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http://dx.doi.org/10.1002/jbm.b.34027DOI Listing
August 2018

Is Total Disk Replacement a Cost-effective Treatment for Cervical Degenerative Disk Disease?

Clin Spine Surg 2017 Jun;30(5):E530-E534

*Department of Orthopaedics, Trauma Surgery and Spinal Cord Injury †Department of Anaesthesiology ‡Research Centre for Experimental Orthopaedics University Hospital of Heidelberg, Heidelberg §Stadtklinik Baden-Baden, Baden-Baden, Germany.

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http://dx.doi.org/10.1097/BSD.0000000000000189DOI Listing
June 2017

Global chondrocyte gene expression after a single anabolic loading period: Time evolution and re-inducibility of mechano-responses.

J Cell Physiol 2018 Jan 19;233(1):699-711. Epub 2017 May 19.

Orthopaedic University Hospital Heidelberg, Research Centre for Experimental Orthopaedics, Heidelberg, Germany.

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http://dx.doi.org/10.1002/jcp.25933DOI Listing
January 2018

Peptide-functionalized starPEG/heparin hydrogels direct mitogenicity, cell morphology and cartilage matrix distribution in vitro and in vivo.

J Tissue Eng Regen Med 2018 01 4;12(1):229-239. Epub 2017 Jun 4.

Research Centre for Experimental Orthopaedics, Orthopaedic University Hospital Heidelberg, Germany.

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http://dx.doi.org/10.1002/term.2404DOI Listing
January 2018

Differential expression of TGF-β superfamily members and role of Smad1/5/9-signalling in chondral versus endochondral chondrocyte differentiation.

Sci Rep 2016 11 16;6:36655. Epub 2016 Nov 16.

Research Centre for Experimental Orthopaedics, Orthopaedic University Hospital Heidelberg, Heidelberg, Germany.

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http://dx.doi.org/10.1038/srep36655DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5111074PMC
November 2016

Fibrinogen scaffolds with immunomodulatory properties promote in vivo bone regeneration.

Biomaterials 2016 12 4;111:163-178. Epub 2016 Oct 4.

i3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Rua Alfredo Allen, 208, 4200-135 Porto, Portugal; INEB - Instituto de Engenharia Biomédica, Universidade do Porto, Rua Alfredo Allen, 208, 4200-135 Porto, Portugal; ICBAS-Instituto de Ciências Biomédicas Abel Salazar, Universidade do Porto, Rua de Jorge Viterbo Ferreira 228, 4050-313 Porto, Portugal.

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http://dx.doi.org/10.1016/j.biomaterials.2016.10.004DOI Listing
December 2016

Role of PTHrP(1-34) Pulse Frequency Versus Pulse Duration to Enhance Mesenchymal Stromal Cell Chondrogenesis.

J Cell Physiol 2016 Dec 21;231(12):2673-81. Epub 2016 Mar 21.

Research Centre for Experimental Orthopedics, University Hospital Heidelberg, Heidelberg, Germany.

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http://dx.doi.org/10.1002/jcp.25369DOI Listing
December 2016

Differential Regulation of SOX9 Protein During Chondrogenesis of Induced Pluripotent Stem Cells Versus Mesenchymal Stromal Cells: A Shortcoming for Cartilage Formation.

Stem Cells Dev 2016 Apr 23;25(8):598-609. Epub 2016 Mar 23.

1 Research Center for Experimental Orthopedics, Orthopedic University Hospital Heidelberg , Heidelberg, Germany .

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http://dx.doi.org/10.1089/scd.2015.0312DOI Listing
April 2016

Stage-Specific miRs in Chondrocyte Maturation: Differentiation-Dependent and Hypertrophy-Related miR Clusters and the miR-181 Family.

Tissue Eng Part A 2015 Dec 13;21(23-24):2840-51. Epub 2015 Nov 13.

1 Research Centre for Experimental Orthopaedics, Orthopaedic University Hospital Heidelberg , Heidelberg, Germany .

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http://dx.doi.org/10.1089/ten.TEA.2015.0352DOI Listing
December 2015

Mesenchymal stromal cell implantation for stimulation of long bone healing aggravates Staphylococcus aureus induced osteomyelitis.

Acta Biomater 2015 Jul 22;21:165-77. Epub 2015 Mar 22.

Research Centre for Experimental Orthopaedics, Orthopaedic University Hospital Heidelberg, Schlierbacher Landstrasse 200a, 69118 Heidelberg, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.actbio.2015.03.019DOI Listing
July 2015

Superior angiogenic potential of GDF-5 and GDF-5(V453/V456) compared with BMP-2 in a rabbit long-bone defect model.

J Bone Joint Surg Am 2014 Oct;96(20):1699-707

Research Centre for Experimental Orthopaedics, Heidelberg University Hospital, Schlierbacher Landstrasse 200a, 69118 Heidelberg, Germany. E-mail address for W. Richter:

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http://dx.doi.org/10.2106/JBJS.M.01462DOI Listing
October 2014

Xenogeneic transplantation of articular chondrocytes into full-thickness articular cartilage defects in minipigs: fate of cells and the role of macrophages.

Cell Tissue Res 2014 Dec 17;358(3):749-61. Epub 2014 Aug 17.

Research Center for Experimental Orthopaedics, Orthopaedic University Hospital Heidelberg, Schlierbacher Landstrasse 200a, 69118, Heidelberg, Germany,

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http://dx.doi.org/10.1007/s00441-014-1982-xDOI Listing
December 2014

Mesenchymal stroma cells trigger early attraction of M1 macrophages and endothelial cells into fibrin hydrogels, stimulating long bone healing without long-term engraftment.

Acta Biomater 2014 Nov 22;10(11):4730-4741. Epub 2014 Jul 22.

Research Centre for Experimental Orthopaedics, Orthopaedic University Hospital Heidelberg, Schlierbacher Landstrasse 200a, 69118 Heidelberg, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.actbio.2014.07.017DOI Listing
November 2014

Regulating chondrogenesis of human mesenchymal stromal cells with a retinoic Acid receptor-Beta inhibitor: differential sensitivity of chondral versus osteochondral development.

Cell Physiol Biochem 2014 16;33(6):1607-19. Epub 2014 May 16.

Research Center for Experimental Orthopaedics, Heidelberg University Hospital, Heidelberg, Germany.

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http://dx.doi.org/10.1159/000358723DOI Listing
September 2015

Intermittent PTHrP(1-34) exposure augments chondrogenesis and reduces hypertrophy of mesenchymal stromal cells.

Stem Cells Dev 2014 Oct 2;23(20):2513-23. Epub 2014 Jul 2.

Research Center for Experimental Orthopaedics, Orthopaedic University Hospital Heidelberg , Heidelberg, Germany .

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http://dx.doi.org/10.1089/scd.2014.0101DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4186799PMC
October 2014

Complete subchondral bone defect regeneration with a tricalcium phosphate collagen implant and osteoinductive growth factors: a randomized controlled study in Göttingen minipigs.

J Biomed Mater Res B Appl Biomater 2014 Jul 21;102(5):933-42. Epub 2013 Nov 21.

Clinic of Orthopaedic and Trauma Surgery, Heidelberg University Hospital, Heidelberg, Germany.

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http://dx.doi.org/10.1002/jbm.b.33074DOI Listing
July 2014

Enhanced reconstruction of long bone architecture by a growth factor mutant combining positive features of GDF-5 and BMP-2.

Biomaterials 2013 Aug 13;34(24):5926-36. Epub 2013 May 13.

Research Centre for Experimental Orthopaedics, Orthopaedic University Hospital Heidelberg, Schlierbacher Landstrasse 200a, 69118 Heidelberg, Germany.

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http://dx.doi.org/10.1016/j.biomaterials.2013.04.029DOI Listing
August 2013

The collagen component of biological bone graft substitutes promotes ectopic bone formation by human mesenchymal stem cells.

Acta Biomater 2013 Jul 28;9(7):7298-307. Epub 2013 Mar 28.

Research Centre for Experimental Orthopaedics, Heidelberg University Hospital, Germany.

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http://dx.doi.org/10.1016/j.actbio.2013.03.037DOI Listing
July 2013

No effect of subperiosteal growth factor application on periosteal neo-chondrogenesis in osteoperiosteal bone grafts for osteochondral defect repair.

Int Orthop 2013 Jun 17;37(6):1171-8. Epub 2013 Mar 17.

Clinic of Orthopaedic and Trauma Surgery, Heidelberg University Hospital, Schlierbacher Landstrasse 200a, 69118, Heidelberg, Germany.

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http://dx.doi.org/10.1007/s00264-013-1827-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3664158PMC
June 2013

BMP and TGFbeta pathways in human central chondrosarcoma: enhanced endoglin and Smad 1 signaling in high grade tumors.

BMC Cancer 2012 Oct 22;12:488. Epub 2012 Oct 22.

Research Centre for Experimental Orthopaedics, Department of Orthopaedics, Trauma Surgery and Paraplegiology, Heidelberg University Hospital, Schlierbacher Landstrasse 200a, 69118, Heidelberg, Germany.

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http://dx.doi.org/10.1186/1471-2407-12-488DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3495847PMC
October 2012

Regulation of H19 and its encoded microRNA-675 in osteoarthritis and under anabolic and catabolic in vitro conditions.

J Mol Med (Berl) 2012 Oct 21;90(10):1185-95. Epub 2012 Apr 21.

Research Centre for Experimental Orthopaedics, Orthopaedic University Hospital Heidelberg, Schlierbacher Landstrasse 200a, 69118, Heidelberg, Germany.

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http://dx.doi.org/10.1007/s00109-012-0895-yDOI Listing
October 2012

Interplay between local versus soluble transforming growth factor-beta and fibrin scaffolds: role of cells and impact on human mesenchymal stem cell chondrogenesis.

Tissue Eng Part A 2012 Jun 14;18(11-12):1140-50. Epub 2012 May 14.

Research Center for Experimental Orthopaedics, Heidelberg University Hospital, Heidelberg, Germany.

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https://www.liebertpub.com/doi/10.1089/ten.tea.2011.0426
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http://dx.doi.org/10.1089/ten.TEA.2011.0426DOI Listing
June 2012

OA in 2011: Age-related OA--a concept emerging from infancy?

Nat Rev Rheumatol 2012 Jan 10;8(2):70-2. Epub 2012 Jan 10.

Institute of Pathology, Medical Center Coburg, Ketschendorferstraße 33, 96450 Coburg, Germany.

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http://www.nature.com/articles/nrrheum.2011.206
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http://dx.doi.org/10.1038/nrrheum.2011.206DOI Listing
January 2012

Proliferation as a requirement for in vitro chondrogenesis of human mesenchymal stem cells.

Stem Cells Dev 2012 Aug 15;21(12):2160-9. Epub 2012 Feb 15.

Research Centre for Experimental Orthopaedics, Orthopaedic University Hospital Heidelberg, Heidelberg, Germany.

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http://dx.doi.org/10.1089/scd.2011.0670DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3411365PMC
August 2012

Engineering hydrophobin DewA to generate surfaces that enhance adhesion of human but not bacterial cells.

Acta Biomater 2012 Mar 2;8(3):1037-47. Epub 2011 Dec 2.

Research Centre for Experimental Orthopaedics, Orthopaedic University Hospital Heidelberg, Schlierbacher Landstrasse 200a, 69118 Heidelberg, Germany.

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http://dx.doi.org/10.1016/j.actbio.2011.11.022DOI Listing
March 2012

Reduced reactivation from dormancy but maintained lineage choice of human mesenchymal stem cells with donor age.

PLoS One 2011 5;6(8):e22980. Epub 2011 Aug 5.

Research Center for Experimental Orthopedics, Orthopedic University Hospital Heidelberg, Heidelberg, Germany.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0022980PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3151268PMC
February 2012

Chondrogenesis of mesenchymal stem cells: role of tissue source and inducing factors.

Stem Cell Res Ther 2010 Oct 13;1(4):31. Epub 2010 Oct 13.

Research Centre for Experimental Orthopaedics, Orthopaedic University Hospital Heidelberg, Schlierbacher Landstrasse 200a, 69118 Heidelberg, Germany.

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http://stemcellres.com/content/1/4/31
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http://dx.doi.org/10.1186/scrt31DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2983444PMC
October 2010

Influence of depression symptoms on serum tumor necrosis factor-α of patients with chronic low back pain.

Arthritis Res Ther 2010 11;12(5):R186. Epub 2010 Oct 11.

Department of Orthopaedic Surgery, University of Heidelberg, Schlierbacher Landstrasse 200a, 69118 Heidelberg, Germany.

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http://dx.doi.org/10.1186/ar3156DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2991021PMC
March 2011

Enhanced biochemical and biomechanical properties of scaffolds generated by flock technology for cartilage tissue engineering.

Tissue Eng Part A 2010 Dec 1;16(12):3697-707. Epub 2010 Sep 1.

Research Center for Experimental Orthopaedics, Orthopaedic University Hospital Heidelberg, Heidelberg, Germany.

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https://www.liebertpub.com/doi/10.1089/ten.tea.2009.0817
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http://dx.doi.org/10.1089/ten.TEA.2009.0817DOI Listing
December 2010

Discrimination between cells of murine and human origin in xenotransplants by species specific genomic in situ hybridization.

Xenotransplantation 2010 Mar-Apr;17(2):153-9

Research Center for Experimental Orthopaedics, Orthopaedic University Hospital, Heidelberg, Germany.

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http://doi.wiley.com/10.1111/j.1399-3089.2010.00577.x
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http://dx.doi.org/10.1111/j.1399-3089.2010.00577.xDOI Listing
September 2010

Correlation of hypoxic signalling to histological grade and outcome in cartilage tumours.

Histopathology 2010 Apr;56(5):641-51

Orthopaedic University Hospital of Heidelberg, Heidelberg, Germany.

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http://dx.doi.org/10.1111/j.1365-2559.2010.03528.xDOI Listing
April 2010

The effect of two point mutations in GDF-5 on ectopic bone formation in a beta-tricalciumphosphate scaffold.

Biomaterials 2010 May 18;31(14):3878-84. Epub 2010 Feb 18.

Research Center for Experimental Orthopaedics, Orthopaedic University Hospital Heidelberg, Heidelberg, Germany.

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http://dx.doi.org/10.1016/j.biomaterials.2010.01.109DOI Listing
May 2010

Chondrogenic pre-induction of human mesenchymal stem cells on beta-TCP: enhanced bone quality by endochondral heterotopic bone formation.

Acta Biomater 2010 Aug 1;6(8):3292-301. Epub 2010 Feb 1.

Division of Experimental Orthopaedics, Orthopaedic University Hospital of Heidelberg, Schlierbacher Landstrasse 200a, D-69118 Heidelberg, Germany.

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http://dx.doi.org/10.1016/j.actbio.2010.01.037DOI Listing
August 2010

Methods to monitor distribution and metabolic activity of mesenchymal stem cells following in vivo injection into nucleotomized porcine intervertebral discs.

Eur Spine J 2010 Apr 29;19(4):601-12. Epub 2009 Dec 29.

Division of Experimental Orthopaedics, Orthopaedic University Hospital Heidelberg, Schlierbacher Landstrasse 200a, 69118 Heidelberg, Germany.

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http://dx.doi.org/10.1007/s00586-009-1255-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2899826PMC
April 2010

Sensitivity of notochordal disc cells to mechanical loading: an experimental animal study.

Eur Spine J 2010 Jan 21;19(1):113-21. Epub 2009 Nov 21.

Department of Trauma and Orthopaedic Surgery, BG Trauma Center Ludwigshafen, University of Heidelberg, Ludwig Guttmann Str 13, 67071 Ludwigshafen, Germany.

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http://dx.doi.org/10.1007/s00586-009-1217-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2899741PMC
January 2010

Enhanced ITM2A expression inhibits chondrogenic differentiation of mesenchymal stem cells.

Differentiation 2009 Sep-Oct;78(2-3):108-15. Epub 2009 Jun 21.

Division of Experimental Orthopaedics, Orthopaedic University Hospital of Heidelberg, Germany.

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http://dx.doi.org/10.1016/j.diff.2009.05.007DOI Listing
December 2009

Enhanced early tissue regeneration after matrix-assisted autologous mesenchymal stem cell transplantation in full thickness chondral defects in a minipig model.

Cell Transplant 2009 29;18(8):923-32. Epub 2009 Apr 29.

Department of Orthopaedic Surgery, University of Heidelberg, Heidelberg, Germany.

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http://dx.doi.org/10.3727/096368909X471297DOI Listing
February 2010

Matrix metalloprotease inhibitors suppress initiation and progression of chondrogenic differentiation of mesenchymal stromal cells in vitro.

Stem Cells Dev 2009 Jul-Aug;18(6):881-92

Division of Experimental Orthopaedics, Orthopaedic University Clinic Heidelberg, Heidelberg, Germany.

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http://dx.doi.org/10.1089/scd.2008.0306DOI Listing
September 2009

Calcification or dedifferentiation: requirement to lock mesenchymal stem cells in a desired differentiation stage.

J Cell Physiol 2009 Apr;219(1):219-26

Division of Experimental Orthopaedics University of Heidelberg, Heidelberg, Germany.

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http://dx.doi.org/10.1002/jcp.21673DOI Listing
April 2009

Mesenchymal stem cell differentiation in an experimental cartilage defect: restriction of hypertrophy to bone-close neocartilage.

Stem Cells Dev 2009 Sep;18(7):969-78

Division of Experimental Orthopaedics, Orthopaedic University Hospital Heidelberg, Heidelberg, Germany.

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http://dx.doi.org/10.1089/scd.2008.0213DOI Listing
September 2009

Porosity and pore size of beta-tricalcium phosphate scaffold can influence protein production and osteogenic differentiation of human mesenchymal stem cells: an in vitro and in vivo study.

Acta Biomater 2008 Nov 11;4(6):1904-15. Epub 2008 Jun 11.

Orthopaedic University Hospital Heidelberg, Schlierbacher Landstr. 200a, 69118 Heidelberg, Germany.

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http://dx.doi.org/10.1016/j.actbio.2008.05.017DOI Listing
November 2008

Chondrogenesis of mesenchymal stem cells in gel-like biomaterials in vitro and in vivo.

Front Biosci 2008 May 1;13:4517-28. Epub 2008 May 1.

Division of Experimental Orthopaedics, Orthopaedic University Hospital, Heidelberg, Germany.

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http://dx.doi.org/10.2741/3020DOI Listing
May 2008

The use of mesenchymal stem cells for chondrogenesis.

Injury 2008 Apr;39 Suppl 1:S58-65

Division of Experimental Orthopaedics, Orthopaedic University Hospital Heidelberg, Schlierbacher Landstrasse 2002, Heidelberg, Germany.

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http://dx.doi.org/10.1016/j.injury.2008.01.038DOI Listing
April 2008

Cell-based cartilage repair: illusion or solution for osteoarthritis.

Authors:
Wiltrud Richter

Curr Opin Rheumatol 2007 Sep;19(5):451-6

Division of Experimental Orthopedics, Orthopedic University Hospital Heidelberg, Heidelberg, Germany.

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http://dx.doi.org/10.1097/BOR.0b013e3282a95e4cDOI Listing
September 2007

Detection of apoptotic cartilage cells in symptomatic central tears of the triangular fibrocartilage.

J Hand Surg Am 2007 May-Jun;32(5):618-22

Department of Hand, Plastic and Reconstructive Surgery, Burn Center, BG Trauma Center Ludwigshafen, Plastic and Hand Surgery of the University of Heidelberg, Ludwigshafen, Germany.

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http://dx.doi.org/10.1016/j.jhsa.2007.02.023DOI Listing
July 2007

Reduced chondrogenic potential of adipose tissue derived stromal cells correlates with an altered TGFbeta receptor and BMP profile and is overcome by BMP-6.

J Cell Physiol 2007 Jun;211(3):682-91

Division of Experimental Orthopaedics, Orthopaedic University Hospital of Heidelberg, Germany.

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http://dx.doi.org/10.1002/jcp.20977DOI Listing
June 2007

Long-term mechanical loading of chondrocyte-chitosan biocomposites in vitro enhanced their proteoglycan and collagen content.

Biorheology 2006 ;43(6):709-20

Division of Experimental Orthopaedics, Orthopaedic University Hospital, Heidelberg, Germany.

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May 2007

Platelet-rich plasma improves expansion of human mesenchymal stem cells and retains differentiation capacity and in vivo bone formation in calcium phosphate ceramics.

Platelets 2006 Nov;17(7):462-9

Department of Orthopaedic Surgery, University of Heidelberg, Schlierbacher Landstr. 200a, 69118 Heidelberg, Germany.

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http://dx.doi.org/10.1080/09537100600758867DOI Listing
November 2006

Chondrocyte secreted CRTAC1: a glycosylated extracellular matrix molecule of human articular cartilage.

Matrix Biol 2007 Jan 16;26(1):30-41. Epub 2006 Sep 16.

Division of Experimental Orthopaedics, Orthopaedic University Hospital Heidelberg, Schlierbacher Landstrasse 200a, D-69118 Heidelberg, Germany.

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http://linkinghub.elsevier.com/retrieve/pii/S0945053X0600369
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http://dx.doi.org/10.1016/j.matbio.2006.09.006DOI Listing
January 2007

Influence of platelet-rich plasma on osteogenic differentiation of mesenchymal stem cells and ectopic bone formation in calcium phosphate ceramics.

Cells Tissues Organs 2006 ;183(2):68-79

Division of Experimental Orthopaedics, Orthopaedic University Hospital Heidelberg, Heidelberg, Germany.

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http://dx.doi.org/10.1159/000095511DOI Listing
December 2006

Osteoarthritis: cellular and molecular changes in degenerating cartilage.

Prog Histochem Cytochem 2006 23;40(3):135-63. Epub 2006 Mar 23.

Stiftung Orthopädische Universitätsklinik Heidelberg, Sektion Experimentelle Orthopädie, Schlierbacher Landstrasse 200a, 69118 Heidelberg, Germany.

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http://dx.doi.org/10.1016/j.proghi.2006.02.003DOI Listing
January 2007

Accelerated intervertebral disc degeneration in scoliosis versus physiological ageing develops against a background of enhanced anabolic gene expression.

Biochem Biophys Res Commun 2006 Apr;342(3):963-72

Division of Experimental Orthopaedics, Orthopaedic University Hospital Heidelberg, D-69118 Heidelberg, Germany.

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http://dx.doi.org/10.1016/j.bbrc.2006.02.048DOI Listing
April 2006

An in vivo study of a growth-factor enhanced, cell free, two-layered collagen-tricalcium phosphate in deep osteochondral defects.

Biomaterials 2006 Jun 20;27(18):3387-95. Epub 2006 Feb 20.

Department of Orthopaedics, University of Heidelberg, Schlierbacher Landstrasse 200a, 69118 Heidelberg, Germany.

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http://dx.doi.org/10.1016/j.biomaterials.2006.01.041DOI Listing
June 2006

Stimulation of gene expression and loss of anular architecture caused by experimental disc degeneration--an in vivo animal study.

Spine (Phila Pa 1976) 2005 Nov;30(22):2510-5

Department of Orthopedic Surgery, University of Heidelberg, Heidelberg, Switzerland.

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http://dx.doi.org/10.1097/01.brs.0000186591.17114.e9DOI Listing
November 2005

Vascular endothelial growth factor gene-activated matrix (VEGF165-GAM) enhances osteogenesis and angiogenesis in large segmental bone defects.

J Bone Miner Res 2005 Nov 5;20(11):2028-35. Epub 2005 Jul 5.

Department of Orthopaedic Surgery, University of Heidelberg, Heidelberg, Germany.

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http://dx.doi.org/10.1359/JBMR.050701DOI Listing
November 2005

Molecular characterization of spontaneous and growth-factor-augmented chondrogenesis in periosteum-bone tissue transferred into a joint.

Histochem Cell Biol 2005 Jun 1;123(4-5):447-56. Epub 2005 Jun 1.

Department of Orthopaedic Surgery, University of Heidelberg, Schlierbacher Landstrasse 200a, 69120 Heidelberg, Germany.

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http://dx.doi.org/10.1007/s00418-005-0775-4DOI Listing
June 2005

Tissue distribution of a human Ca v 1.2 alpha1 subunit splice variant with a 75 bp insertion.

Cell Calcium 2005 Jul;38(1):11-21

Institut für Pharmakologie und Toxikologie, Medizinische Fakultät Carl Gustav Carus der TU Dresden, Fetscherstr. 74, D-01307 Dresden, Germany.

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http://linkinghub.elsevier.com/retrieve/pii/S014341600500069
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http://dx.doi.org/10.1016/j.ceca.2005.03.005DOI Listing
July 2005

Ectopic bone formation associated with mesenchymal stem cells in a resorbable calcium deficient hydroxyapatite carrier.

Biomaterials 2005 Oct;26(29):5879-89

Department of Orthopaedic Surgery, University of Heidelberg, Schlierbacher Landstr. 200a, 69118 Heidelberg, Germany.

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http://dx.doi.org/10.1016/j.biomaterials.2005.03.001DOI Listing
October 2005

Matrix-assisted cell transfer for intervertebral disc cell therapy.

Biochem Biophys Res Commun 2005 Jun;331(4):1185-92

Division of Experimental Orthopaedics, Orthopaedic University Hospital Heidelberg, D-69118 Heidelberg, Germany.

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http://linkinghub.elsevier.com/retrieve/pii/S0006291X0500781
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http://dx.doi.org/10.1016/j.bbrc.2005.04.034DOI Listing
June 2005

Induction of intervertebral disc-like cells from adult mesenchymal stem cells.

Stem Cells 2005 Mar;23(3):403-11

Division of Experimental Orthopaedics, Orthopaedic Clinic, University of Heidelberg, Schlierbacher Landstr. 200a, D-69118 Heidelberg, Germany.

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http://dx.doi.org/10.1634/stemcells.2004-0107DOI Listing
March 2005

Occurrence and regional distribution of apoptosis in scoliotic discs.

Spine (Phila Pa 1976) 2005 Mar;30(5):519-24

Division of Experimental Orthopedics, Orthopedic University Hospital, Heidelberg, Germany.

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http://dx.doi.org/10.1097/01.brs.0000154652.96975.1fDOI Listing
March 2005

Stiff-person syndromes: motor cortex hyperexcitability correlates with anti-GAD autoimmunity.

Neurology 2004 Apr;62(8):1357-62

Department of Neurology, Ruprecht-Karls-University Heidelberg, FRG.

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http://dx.doi.org/10.1212/01.wnl.0000120543.65812.33DOI Listing
April 2004

Release of active and depot GDF-5 after adenovirus-mediated overexpression stimulates rabbit and human intervertebral disc cells.

J Mol Med (Berl) 2004 Feb 11;82(2):126-34. Epub 2003 Dec 11.

Division of Experimental Orthopaedics, University of Heidelberg, Schlierbacher Landstrasse 200a, 69118, Heidelberg, Germany.

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http://dx.doi.org/10.1007/s00109-003-0507-yDOI Listing
February 2004

Telomere length and telomerase activity during expansion and differentiation of human mesenchymal stem cells and chondrocytes.

J Mol Med (Berl) 2004 Jan 28;82(1):49-55. Epub 2003 Nov 28.

Department of Orthopedic Surgery, University of Heidelberg, Schlierbacher Landstrasse 200, 69118 Heidelberg, Germany.

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http://dx.doi.org/10.1007/s00109-003-0506-zDOI Listing
January 2004

Rapid regulation of collagen but not metalloproteinase 1, 3, 13, 14 and tissue inhibitor of metalloproteinase 1, 2, 3 expression in response to mechanical loading of cartilage explants in vitro.

Arch Biochem Biophys 2003 Feb;410(1):39-47

Department of Orthopaedic Surgery, University of Heidelberg, Abteilung Bereich Forschung, Schlierbacher Landstrasse 200a, 69118 Heidelberg, Germany.

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http://dx.doi.org/10.1016/s0003-9861(02)00658-6DOI Listing
February 2003