Willy Hugo

Willy Hugo

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Willy Hugo

Publications by authors named "Willy Hugo"

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Exploiting Drug Addiction Mechanisms to Select against MAPKi-Resistant Melanoma.

Cancer Discov 2018 01 18;8(1):74-93. Epub 2017 Sep 18.

Division of Dermatology, Department of Medicine, University of California, Los Angeles, California.

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http://dx.doi.org/10.1158/2159-8290.CD-17-0682DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6456057PMC
January 2018

Interferon Receptor Signaling Pathways Regulating PD-L1 and PD-L2 Expression.

Cell Rep 2017 05;19(6):1189-1201

Division of Hematology-Oncology, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles (UCLA), Los Angeles, CA 90095, USA; Department of Molecular and Medical Pharmacology, UCLA, Los Angeles, CA 90095, USA; Jonsson Comprehensive Cancer Center, UCLA, Los Angeles, CA 90095, USA; Division of Surgical Oncology, Department of Surgery, UCLA, Los Angeles, CA 90095, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S22111247173052
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http://dx.doi.org/10.1016/j.celrep.2017.04.031DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6420824PMC
May 2017

Mutations Associated with Acquired Resistance to PD-1 Blockade in Melanoma.

N Engl J Med 2016 Sep 13;375(9):819-29. Epub 2016 Jul 13.

From the University of California, Los Angeles (UCLA) (J.M.Z., A.G.-D., D.S.S., H.E.-O., W.H., S.H.-L., D.Y.T., G.A.-R., S.S., L.B., J.S., B.H.M., B.C., K.R., I.P.S., P.J.S., C.P.-S., G.C., E.S., X.K., J.P., B.B.-M., B.C.-A., T.G.G., P.C.T., R.S.L., A.R.), and Jonsson Comprehensive Cancer Center (B.C., B.C.-A., T.G.G., P.C.T., R.S.L., A.R.) - both in Los Angeles; and the Division of Immunology, Netherlands Cancer Institute, Amsterdam (R.M., T.N.M.S.).

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http://dx.doi.org/10.1056/NEJMoa1604958DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5007206PMC
September 2016

JUN dependency in distinct early and late BRAF inhibition adaptation states of melanoma.

Cell Discov 2016 6;2:16028. Epub 2016 Sep 6.

Department of Molecular and Medical Pharmacology, University of California Los Angeles, Los Angeles, CA, USA; Crump Institute for Molecular Imaging, University of California Los Angeles, Los Angeles, CA, USA; Jonsson Comprehensive Cancer Center, University of California Los Angeles, Los Angeles, CA, USA; California NanoSystems Institute, University of California Los Angeles, Los Angeles, CA, USA.

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http://dx.doi.org/10.1038/celldisc.2016.28DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5012007PMC
September 2016

Genomic and Transcriptomic Features of Response to Anti-PD-1 Therapy in Metastatic Melanoma.

Cell 2016 Mar 17;165(1):35-44. Epub 2016 Mar 17.

Division of Dermatology, Department of Medicine, University of California, Los Angeles, CA 90095-1662, USA; Department of Molecular and Medical Pharmacology, University of California, Los Angeles, CA 90095-1662, USA; Jonsson Comprehensive Cancer Center, University of California, Los Angeles, CA 90095-1662, USA; David Geffen School of Medicine, University of California, Los Angeles, CA 90095-1662, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2016.02.065DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4808437PMC
March 2016

Non-genomic and Immune Evolution of Melanoma Acquiring MAPKi Resistance.

Cell 2015 Sep;162(6):1271-85

Division of Dermatology, Department of Medicine, University of California, Los Angeles, Los Angeles, CA 90095-1662, USA; Department of Molecular and Medical Pharmacology, University of California, Los Angeles, Los Angeles, CA 90095-1662, USA; Jonsson Comprehensive Cancer Center, University of California, Los Angeles, Los Angeles, CA 90095-1662, USA; David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095-1662, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2015.07.061DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4821508PMC
September 2015

Tunable-combinatorial mechanisms of acquired resistance limit the efficacy of BRAF/MEK cotargeting but result in melanoma drug addiction.

Cancer Cell 2015 Feb 15;27(2):240-56. Epub 2015 Jan 15.

Division of Dermatology, Department of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA; Department of Molecular and Medical Pharmacology, University of California, Los Angeles, Los Angeles, CA 90095, USA; Jonsson Comprehensive Cancer Center, University of California, Los Angeles, Los Angeles, CA 90095, USA; David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2014.11.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4326539PMC
February 2015

Response of BRAF-mutant melanoma to BRAF inhibition is mediated by a network of transcriptional regulators of glycolysis.

Cancer Discov 2014 Apr 27;4(4):423-33. Epub 2014 Jan 27.

1Molecular Oncology Laboratory, Oncogenic Signaling and Growth Control Program, 2Translational Research Laboratory, Cancer Therapeutics Program, 3Bioinformatics Core Facility, 4The Cancer Signalling Laboratory, Oncogenic Signaling and Growth Control Program, 5Gene Regulation Laboratory, Cancer Therapeutics Program, 6Molecular Imaging and Targeted Therapeutics Laboratory, Cancer Therapeutics Program, 7Department of Cancer Imaging, Peter MacCallum Cancer Centre, East Melbourne; 8Sir Peter MacCallum Department of Oncology, Departments of 9Biochemistry and Molecular Biology, and 10Pathology, University of Melbourne, Parkville; 11Metabolic Remodelling Laboratory, Metabolic Research Unit, School of Medicine, Deakin University, Waurn Ponds; 12Department of Medicine, St Vincent's Hospital, University of Melbourne, Fitzroy, Victoria; 13Westmead Institute for Cancer Research, University of Sydney at Westmead Millennium Institute, Westmead; 14Department of Tissue Pathology & Diagnostic Oncology, Royal Prince Alfred Hospital; 15Discipline of Pathology, Sydney Medical School, The University of Sydney, Sydney, New South Wales, Australia; 16Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah; and 17Jonsson Comprehensive Cancer Center, University of California Los Angeles, Los Angeles, California.

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http://dx.doi.org/10.1158/2159-8290.CD-13-0440DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4110245PMC
April 2014

A novel AKT1 mutant amplifies an adaptive melanoma response to BRAF inhibition.

Cancer Discov 2014 Jan 21;4(1):69-79. Epub 2013 Nov 21.

1The Division of Dermatology, Department of Medicine, 2Division of Surgical Oncology, Department of Surgery, 3Division of Hematology and Oncology, Department of Medicine, 4Jonsson Comprehensive Cancer Center, 5Department of Molecular and Medical Pharmacology, 6David Geffen School of Medicine, University of California, Los Angeles, California; 7Melanoma Institute of Australia, 8Royal Prince Alfred Hospital, 9Westmead Millennium Institute, and 10Westmead Hospital, University of Sydney, New South Wales, Australia.

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http://dx.doi.org/10.1158/2159-8290.CD-13-0279DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3893054PMC
January 2014

Discovering interacting domains and motifs in protein-protein interactions.

Methods Mol Biol 2013 ;939:9-20

School of Computing, National University of Singapore, Singapore, Singapore.

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http://dx.doi.org/10.1007/978-1-62703-107-3_2DOI Listing
June 2013

D-SLIMMER: domain-SLiM interaction motifs miner for sequence based protein-protein interaction data.

J Proteome Res 2011 Dec 1;10(12):5285-95. Epub 2011 Nov 1.

Department of Computer Science, National University of Singapore, 13 Computing Drive, 117417 Singapore.

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http://dx.doi.org/10.1021/pr200312eDOI Listing
December 2011

SLiM on Diet: finding short linear motifs on domain interaction interfaces in Protein Data Bank.

Bioinformatics 2010 Apr 18;26(8):1036-42. Epub 2010 Feb 18.

Department of Computer Science, National University of Singapore, 13 Computing Drive S(117417), Singapore.

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http://dx.doi.org/10.1093/bioinformatics/btq065DOI Listing
April 2010

A probabilistic graph-theoretic approach to integrate multiple predictions for the protein-protein subnetwork prediction challenge.

Ann N Y Acad Sci 2009 Mar;1158:224-33

Data Mining Department, Institute for Infocomm Research, Singapore.

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http://dx.doi.org/10.1111/j.1749-6632.2008.03760.xDOI Listing
March 2009

A correlated motif approach for finding short linear motifs from protein interaction networks.

BMC Bioinformatics 2006 Nov 16;7:502. Epub 2006 Nov 16.

Knowledge Discovery Department, Institute for Infocomm Research, Singapore.

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http://dx.doi.org/10.1186/1471-2105-7-502DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1665647PMC
November 2006

Adaptive control of hybridization noise in DNA sequencing-by-hybridization.

J Bioinform Comput Biol 2005 Feb;3(1):79-98

School of Computing, National University of Singapore, Singapore.

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February 2005