William Y Kim

William Y Kim

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RNA Expression Profiling of Lymphoepithelioma-Like Carcinoma of the Bladder Reveals a Basal-like Molecular Subtype.

Am J Pathol 2019 Oct 11. Epub 2019 Oct 11.

UNC Lineberger Comprehensive Cancer Center;; Department of Pathology and Laboratory Medicine, UNC Chapel Hill;. Electronic address:

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http://dx.doi.org/10.1016/j.ajpath.2019.09.007DOI Listing
October 2019

The Cancer/Testes (CT) Antigen HORMAD1 promotes Homologous Recombinational DNA Repair and Radioresistance in Lung adenocarcinoma cells.

Sci Rep 2018 10 17;8(1):15304. Epub 2018 Oct 17.

Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, 614 Brinkhous-Bullitt Building, Chapel Hill, NC, 27599, USA.

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http://www.nature.com/articles/s41598-018-33601-w
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http://dx.doi.org/10.1038/s41598-018-33601-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6192992PMC
October 2018

Multicenter Prospective Phase II Trial of Neoadjuvant Dose-Dense Gemcitabine Plus Cisplatin in Patients With Muscle-Invasive Bladder Cancer.

J Clin Oncol 2018 07 9;36(19):1949-1956. Epub 2018 May 9.

Gopa Iyer, Bernard H. Bochner, Guido Dalbagni, S. Machele Donat, Harry W. Herr, Irina Ostrovnaya, Hikmat Al-Ahmadie, Maria E. Arcila, Jamie C. Riches, Andreas Meier, Caitlin Bourque, Maha Shady, Helen Won, Brooke E. Kania, Mariel E. Boyd, Catharine K. Cipolla, Ashley M. Regazzi, Asia S. McCoy, Hebert Alberto Vargas, Michael F. Berger, David B. Solit, Jonathan E. Rosenberg, and Dean F. Bajorin, Memorial Sloan Kettering Cancer Center; Gopa Iyer, Bernard H. Bochner, Guido Dalbagni, S. Machele Donat, Harry W. Herr, Hikmat Al-Ahmadie, David B. Solit, and Dean F. Bajorin, Weill Cornell Medical College; Arjun V. Balar, William C. Huang, Samir S. Taneja, and Daniela Delbeau, New York University Langone Medical Center, New York, NY; and Matthew I. Milowsky, Michael Woods, Tracy L. Rose, and William Y. Kim, University of North Carolina Lineberger Comprehensive Cancer Center, Chapel Hill, NC.

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http://dx.doi.org/10.1200/JCO.2017.75.0158DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6049398PMC
July 2018

Consequences of VHL Loss on Global DNA Methylome.

Sci Rep 2018 02 20;8(1):3313. Epub 2018 Feb 20.

Department of Laboratory Medicine and Pathobiology, University of Toronto, 661 University Avenue, Room 1510, M5G1M1, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1038/s41598-018-21524-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5820357PMC
February 2018

Analysis of bladder cancer tumor CpG methylation and gene expression within The Cancer Genome Atlas identifies as a prognostic biomarker for basal-like bladder cancer.

Am J Cancer Res 2017 1;7(9):1850-1862. Epub 2017 Sep 1.

Department of Environmental Sciences and Engineering, Gillings School of Global Public Health, The University of North CarolinaChapel Hill, NC, 27599, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5622220PMC
September 2017

and Determinants of Tumor Grade and mTOR Activation in VHL-Deficient Mouse Models of Renal Cell Carcinoma.

Cancer Discov 2017 08;7(8):802-804

Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.

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http://dx.doi.org/10.1158/2159-8290.CD-17-0610DOI Listing
August 2017

Loss Induces Senescence and Stat3 Activation Coinciding with Tubulointerstitial Fibrosis.

Mol Cell Biol 2017 06 31;37(12). Epub 2017 May 31.

Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA

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http://dx.doi.org/10.1128/MCB.00565-16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5452723PMC
June 2017

Age at diagnosis, obesity, smoking, and molecular subtypes in muscle-invasive bladder cancer.

Cancer Causes Control 2017 Jun 20;28(6):539-544. Epub 2017 Mar 20.

Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Suite 32, CVS Plaza, 137 East Franklin Street, CB#8050, Chapel Hill, NC, 27599, USA.

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http://dx.doi.org/10.1007/s10552-017-0885-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5477976PMC
June 2017

Targeting Tumor-Associated Fibroblasts for Therapeutic Delivery in Desmoplastic Tumors.

Cancer Res 2017 02 18;77(3):719-731. Epub 2016 Nov 18.

Division of Molecular Pharmaceutics and Center for Nanotechnology in Drug Delivery, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.

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http://dx.doi.org/10.1158/0008-5472.CAN-16-0866DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5290135PMC
February 2017

Copper(II) Activation of Nitrite: Nitrosation of Nucleophiles and Generation of NO by Thiols.

J Am Chem Soc 2017 01 22;139(3):1045-1048. Epub 2016 Dec 22.

Department of Chemistry, Georgetown University , Box 571227-1227, Washington, D. C. 20057, United States.

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http://dx.doi.org/10.1021/jacs.6b11332DOI Listing
January 2017

Nitric oxide release via oxygen atom transfer from nitrite at copper(ii).

Chem Commun (Camb) 2017 01;53(3):549-552

Department of Chemistry, Georgetown University, Washington, DC, USA.

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http://dx.doi.org/10.1039/c6cc08745kDOI Listing
January 2017

Racial disparities in survival among patients with advanced renal cell carcinoma in the targeted therapy era.

Cancer 2016 10 24;122(19):2988-95. Epub 2016 Jun 24.

Division of Hematology/Oncology, Department of Medicine, University of North Carolina, Chapel Hill, North Carolina.

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http://dx.doi.org/10.1002/cncr.30146DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5030137PMC
October 2016

The Binding Site Barrier Elicited by Tumor-Associated Fibroblasts Interferes Disposition of Nanoparticles in Stroma-Vessel Type Tumors.

ACS Nano 2016 Oct 28;10(10):9243-9258. Epub 2016 Sep 28.

Division of Molecular Pharmaceutics and Center of Nanotechnology in Drug Delivery, Eshelman School of Pharmacy, ‡Lineberger Comprehensive Cancer Center, §Departments of Mathematics and Applied Physical Science, ∥Department of Medicine, ⊥Department of Pathology, University of North Carolina at Chapel Hill , Chapel Hill, North Carolina 27599, United States.

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http://dx.doi.org/10.1021/acsnano.6b02776DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5515694PMC
October 2016

Intrinsic Genomic Differences Between African American and White Patients With Clear Cell Renal Cell Carcinoma.

JAMA Oncol 2016 May;2(5):664-667

Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill2Department of Medicine, Division of Hematology/Oncology, University of North Carolina at Chapel Hill, Chapel Hill3Department of Urology, University of North C.

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http://dx.doi.org/10.1001/jamaoncol.2016.0005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5035632PMC
May 2016

Comprehensive Molecular Characterization of Papillary Renal-Cell Carcinoma.

Authors:
W Marston Linehan Paul T Spellman Christopher J Ricketts Chad J Creighton Suzanne S Fei Caleb Davis David A Wheeler Bradley A Murray Laura Schmidt Cathy D Vocke Myron Peto Abu Amar M Al Mamun Eve Shinbrot Anurag Sethi Samira Brooks W Kimryn Rathmell Angela N Brooks Katherine A Hoadley A Gordon Robertson Denise Brooks Reanne Bowlby Sara Sadeghi Hui Shen Daniel J Weisenberger Moiz Bootwalla Stephen B Baylin Peter W Laird Andrew D Cherniack Gordon Saksena Scott Haake Jun Li Han Liang Yiling Lu Gordon B Mills Rehan Akbani Mark D M Leiserson Benjamin J Raphael Pavana Anur Donald Bottaro Laurence Albiges Nandita Barnabas Toni K Choueiri Bogdan Czerniak Andrew K Godwin A Ari Hakimi Thai H Ho James Hsieh Michael Ittmann William Y Kim Bhavani Krishnan Maria J Merino Kenna R Mills Shaw Victor E Reuter Ed Reznik Carl S Shelley Brian Shuch Sabina Signoretti Ramaprasad Srinivasan Pheroze Tamboli George Thomas Satish Tickoo Kenneth Burnett Daniel Crain Johanna Gardner Kevin Lau David Mallery Scott Morris Joseph D Paulauskis Robert J Penny Candace Shelton W Troy Shelton Mark Sherman Eric Thompson Peggy Yena Melissa T Avedon Jay Bowen Julie M Gastier-Foster Mark Gerken Kristen M Leraas Tara M Lichtenberg Nilsa C Ramirez Tracie Santos Lisa Wise Erik Zmuda John A Demchok Ina Felau Carolyn M Hutter Margi Sheth Heidi J Sofia Roy Tarnuzzer Zhining Wang Liming Yang Jean C Zenklusen Jiashan Zhang Brenda Ayala Julien Baboud Sudha Chudamani Jia Liu Laxmi Lolla Rashi Naresh Todd Pihl Qiang Sun Yunhu Wan Ye Wu Adrian Ally Miruna Balasundaram Saianand Balu Rameen Beroukhim Tom Bodenheimer Christian Buhay Yaron S N Butterfield Rebecca Carlsen Scott L Carter Hsu Chao Eric Chuah Amanda Clarke Kyle R Covington Mahmoud Dahdouli Ninad Dewal Noreen Dhalla Harsha V Doddapaneni Jennifer A Drummond Stacey B Gabriel Richard A Gibbs Ranabir Guin Walker Hale Alicia Hawes D Neil Hayes Robert A Holt Alan P Hoyle Stuart R Jefferys Steven J M Jones Corbin D Jones Divya Kalra Christie Kovar Lora Lewis Jie Li Yussanne Ma Marco A Marra Michael Mayo Shaowu Meng Matthew Meyerson Piotr A Mieczkowski Richard A Moore Donna Morton Lisle E Mose Andrew J Mungall Donna Muzny Joel S Parker Charles M Perou Jeffrey Roach Jacqueline E Schein Steven E Schumacher Yan Shi Janae V Simons Payal Sipahimalani Tara Skelly Matthew G Soloway Carrie Sougnez Angela Tam Donghui Tan Nina Thiessen Umadevi Veluvolu Min Wang Matthew D Wilkerson Tina Wong Junyuan Wu Liu Xi Jane Zhou Jason Bedford Fengju Chen Yao Fu Mark Gerstein David Haussler Katayoon Kasaian Phillip Lai Shiyun Ling Amie Radenbaugh David Van Den Berg John N Weinstein Jingchun Zhu Monique Albert Iakovina Alexopoulou Jeremiah J Andersen J Todd Auman John Bartlett Sheldon Bastacky Julie Bergsten Michael L Blute Lori Boice Roni J Bollag Jeff Boyd Erik Castle Ying-Bei Chen John C Cheville Erin Curley Benjamin Davies April DeVolk Rajiv Dhir Laura Dike John Eckman Jay Engel Jodi Harr Ronald Hrebinko Mei Huang Lori Huelsenbeck-Dill Mary Iacocca Bruce Jacobs Michael Lobis Jodi K Maranchie Scott McMeekin Jerome Myers Joel Nelson Jeremy Parfitt Anil Parwani Nicholas Petrelli Brenda Rabeno Somak Roy Andrew L Salner Joel Slaton Melissa Stanton R Houston Thompson Leigh Thorne Kelinda Tucker Paul M Weinberger Cynthia Winemiller Leigh Anne Zach Rosemary Zuna

Bladder Cancer Molecular Taxonomy: Summary from a Consensus Meeting.

Bladder Cancer 2016 Jan 7;2(1):37-47. Epub 2016 Jan 7.

Epithelial Carcinogenesis Group, Spanish National Cancer Research Centre-CNIO, Madrid, Spain and Departament de Ciències Experimentals i de la Salut, Universitat Pompeu Fabra , Barcelona, Spain.

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http://dx.doi.org/10.3233/BLC-150037DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4927916PMC
January 2016

The geriatrics and genetics behind bladder cancer.

Am Soc Clin Oncol Educ Book 2014 :e192-5

From the Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC; Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC.

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http://dx.doi.org/10.14694/EdBook_AM.2014.34.e192DOI Listing
November 2015

Nanoparticle modulation of the tumor microenvironment enhances therapeutic efficacy of cisplatin.

J Control Release 2015 Nov 15;217:27-41. Epub 2015 Aug 15.

Division of Molecular Pharmaceutics and Center of Nanotechnology in Drug Delivery, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jconrel.2015.08.027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4623876PMC
November 2015

mTOR inhibition induces compensatory, therapeutically targetable MEK activation in renal cell carcinoma.

PLoS One 2014 2;9(9):e104413. Epub 2014 Sep 2.

Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America; Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0104413PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4152178PMC
May 2015

Targeting tumor hypoxia with hypoxia-activated prodrugs.

J Clin Oncol 2015 May 23;33(13):1505-8. Epub 2015 Mar 23.

Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC

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http://dx.doi.org/10.1200/JCO.2014.60.0759DOI Listing
May 2015

The next steps in next-gen sequencing of cancer genomes.

J Clin Invest 2015 Feb 2;125(2):462-8. Epub 2015 Feb 2.

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http://dx.doi.org/10.1172/JCI68339DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4319423PMC
February 2015

Coexistent ARID1A-PIK3CA mutations promote ovarian clear-cell tumorigenesis through pro-tumorigenic inflammatory cytokine signalling.

Nat Commun 2015 Jan 27;6:6118. Epub 2015 Jan 27.

1] Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA [2] Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA.

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http://dx.doi.org/10.1038/ncomms7118DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4308813PMC
January 2015

Nanoparticles with Precise Ratiometric Co-Loading and Co-Delivery of Gemcitabine Monophosphate and Cisplatin for Treatment of Bladder Cancer.

Adv Funct Mater 2014 Nov;24(42):6601-6611

Division of Molecular Pharmaceutics and Center of Nanotechnology in Drug Delivery, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.

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http://dx.doi.org/10.1002/adfm.201401076DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4225819PMC
November 2014

Drug efficacy testing in mice.

Curr Top Microbiol Immunol 2012 ;355:19-38

The University of North Carolina, Chapel Hill, NC, USA.

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http://dx.doi.org/10.1007/82_2011_160DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3732649PMC
August 2014

Synergistic anti-tumor effects of combined gemcitabine and cisplatin nanoparticles in a stroma-rich bladder carcinoma model.

J Control Release 2014 May 15;182:90-6. Epub 2014 Mar 15.

Division of Molecular Pharmaceutics and Center for Nanotechnology in Drug Delivery, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jconrel.2014.03.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4009696PMC
May 2014

Intrinsic subtypes of high-grade bladder cancer reflect the hallmarks of breast cancer biology.

Proc Natl Acad Sci U S A 2014 Feb 11;111(8):3110-5. Epub 2014 Feb 11.

Department of Genetics, Department of Medicine, Division of Hematology/Oncology, Department of Surgery, Department of Pathology and Laboratory Medicine, and Department of Pharmacology, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599.

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http://dx.doi.org/10.1073/pnas.1318376111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3939870PMC
February 2014

Trends in stage-specific incidence rates for urothelial carcinoma of the bladder in the United States: 1988 to 2006.

Cancer 2014 Jan 10;120(1):86-95. Epub 2013 Oct 10.

Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina; Department of Urology, University of North Carolina School of Medicine, Chapel Hill, North Carolina; Department of Epidemiology, University of North Carolina Gillings School of Global Public Health, Chapel Hill, North Carolina.

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http://doi.wiley.com/10.1002/cncr.28397
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http://dx.doi.org/10.1002/cncr.28397DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3964001PMC
January 2014

Codelivery of VEGF siRNA and gemcitabine monophosphate in a single nanoparticle formulation for effective treatment of NSCLC.

Mol Ther 2013 Aug 18;21(8):1559-69. Epub 2013 Jun 18.

Division of Molecular Pharmaceutics and Center for Nanotechnology in Drug Delivery, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7571, USA.

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http://dx.doi.org/10.1038/mt.2013.120DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3734668PMC
August 2013

Stearoyl co-A desaturase 1 as a ccRCC therapeutic target: death by stress.

Clin Cancer Res 2013 Jun 24;19(12):3111-3. Epub 2013 May 24.

Department of Medicine and Genetics, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA.

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http://dx.doi.org/10.1158/1078-0432.CCR-13-0800DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3898854PMC
June 2013

HIF1α and HIF2α independently activate SRC to promote melanoma metastases.

J Clin Invest 2013 May 8;123(5):2078-93. Epub 2013 Apr 8.

Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599-7295, USA.

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http://dx.doi.org/10.1172/JCI66715DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3635738PMC
May 2013

Systemic delivery of gemcitabine triphosphate via LCP nanoparticles for NSCLC and pancreatic cancer therapy.

Biomaterials 2013 Apr 4;34(13):3447-58. Epub 2013 Feb 4.

Division of Molecular Pharmaceutics and Center for Nanotechnology in Drug Delivery, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7571, USA.

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http://dx.doi.org/10.1016/j.biomaterials.2013.01.063DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3600638PMC
April 2013

Neoadjuvant docetaxel/estramustine prior to radical prostatectomy or external beam radiotherapy in high risk localized prostate cancer: a phase II trial.

Urol Oncol 2011 Nov-Dec;29(6):608-13. Epub 2009 Dec 21.

Department of Medicine, Division of Hematology/Oncology, Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599, USA.

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http://dx.doi.org/10.1016/j.urolonc.2009.09.012DOI Listing
March 2012

Two sides to every story: the HIF-dependent and HIF-independent functions of pVHL.

J Cell Mol Med 2011 Feb;15(2):187-95

Departments of Medicine and Genetics, Division of Hematology/Oncology, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.

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http://dx.doi.org/10.1111/j.1582-4934.2010.01238.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3229769PMC
February 2011

HIF, hypoxia and the role of angiogenesis in non-small cell lung cancer.

Expert Opin Ther Targets 2010 Oct;14(10):1047-57

The University of North Carolina, The Lineberger Comprehensive Cancer Center, Chapel Hill, NC 27599-7295, USA.

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http://dx.doi.org/10.1517/14728222.2010.511617DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3646329PMC
October 2010

Regulation of endocytosis via the oxygen-sensing pathway.

Nat Med 2009 Mar 1;15(3):319-24. Epub 2009 Mar 1.

Department of Laboratory Medicine and Pathobiology, St. Michael's Hospital, University of Toronto, 1 King's College Circle, Toronto, Ontario M5S 1A8, Canada.

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http://dx.doi.org/10.1038/nm.1922DOI Listing
March 2009

VHL inactivation: a new road to senescence.

Cancer Cell 2008 Apr;13(4):295-7

Department of Medicine, Lineberger Comprehensive Cancer Center, University of North Carolina School of Medicine, Chapel Hill, NC 27599-7295, USA.

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http://dx.doi.org/10.1016/j.ccr.2008.03.012DOI Listing
April 2008

mTOR pathway in renal cell carcinoma.

Expert Rev Anticancer Ther 2008 Feb;8(2):283-92

Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, CB 7295, Chapel Hill, NC 27599, USA.

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http://dx.doi.org/10.1586/14737140.8.2.283DOI Listing
February 2008

Dominant-negative HIF-3 alpha 4 suppresses VHL-null renal cell carcinoma progression.

Cell Cycle 2007 Nov 29;6(22):2810-6. Epub 2007 Aug 29.

Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.4161/cc.6.22.4947DOI Listing
November 2007

Dexamethasone-induced posterior reversible encephalopathy syndrome.

J Clin Oncol 2007 Jun;25(17):2484-6

University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

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http://ascopubs.org/doi/10.1200/JCO.2007.10.9991
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http://dx.doi.org/10.1200/JCO.2007.10.9991DOI Listing
June 2007

Failure to prolyl hydroxylate hypoxia-inducible factor alpha phenocopies VHL inactivation in vivo.

EMBO J 2006 Oct 14;25(19):4650-62. Epub 2006 Sep 14.

Department of Medical Oncology, Dana-Farber Cancer Institute and Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1038/sj.emboj.7601300DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1589988PMC
October 2006

Molecular pathways in renal cell carcinoma--rationale for targeted treatment.

Semin Oncol 2006 Oct;33(5):588-95

Department of Hematology Oncology, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

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http://dx.doi.org/10.1053/j.seminoncol.2006.06.001DOI Listing
October 2006

The regulation of INK4/ARF in cancer and aging.

Cell 2006 Oct;127(2):265-75

Department of Medicine, The University of North Carolina School of Medicine, Chapel Hill, 27599, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S009286740601284
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http://dx.doi.org/10.1016/j.cell.2006.10.003DOI Listing
October 2006

Mouse model for noninvasive imaging of HIF prolyl hydroxylase activity: assessment of an oral agent that stimulates erythropoietin production.

Proc Natl Acad Sci U S A 2006 Jan 22;103(1):105-10. Epub 2005 Dec 22.

Department of Medical Oncology, Dana-Farber Cancer Institute, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.

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http://www.pnas.org/cgi/doi/10.1073/pnas.0509459103
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http://dx.doi.org/10.1073/pnas.0509459103DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1324998PMC
January 2006

Role of VHL gene mutation in human cancer.

J Clin Oncol 2004 Dec;22(24):4991-5004

Dana-Farber Cancer Institute and Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.

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http://ascopubs.org/doi/10.1200/JCO.2004.05.061
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http://dx.doi.org/10.1200/JCO.2004.05.061DOI Listing
December 2004

Analysis of von Hippel-Lindau hereditary cancer syndrome: implications of oxygen sensing.

Methods Enzymol 2004 ;381:320-35

Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S00766879048102
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http://dx.doi.org/10.1016/S0076-6879(04)81022-XDOI Listing
May 2004

Inhibition of HIF2alpha is sufficient to suppress pVHL-defective tumor growth.

PLoS Biol 2003 Dec 22;1(3):E83. Epub 2003 Dec 22.

Department of Adult Oncology, Dana-Farber Cancer Institute and Brigham and Womens Hospital, Harvard Medical School, Boston, Massachusetts, USA.

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https://dx.plos.org/10.1371/journal.pbio.0000083
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http://dx.doi.org/10.1371/journal.pbio.0000083DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC300692PMC
December 2003

Mouse reporter strain for noninvasive bioluminescent imaging of cells that have undergone Cre-mediated recombination.

Mol Imaging 2003 Oct;2(4):297-302

Dana-Farber Cancer Institute and Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1162/153535003322750637DOI Listing
October 2003

An intact NEDD8 pathway is required for Cullin-dependent ubiquitylation in mammalian cells.

EMBO Rep 2002 Feb 29;3(2):177-82. Epub 2002 Jan 29.

Department of Adult Oncology, Dana-Farber Cancer Institute and Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1093/embo-reports/kvf028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1083969PMC
February 2002