William W Lockwood

William W Lockwood

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William W Lockwood

William W Lockwood

Publications by authors named "William W Lockwood"

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Integrative Genomic Analyses Identifies GGA2 as a Cooperative Driver of EGFR-Mediated Lung Tumorigenesis.

J Thorac Oncol 2019 04 19;14(4):656-671. Epub 2018 Dec 19.

Integrative Oncology, British Columbia Cancer Research Centre, Vancouver, British Columbia, Canada; Department of Pathology, University of British Columbia, Vancouver, British Columbia, Canada; Interdisciplinary Oncology Program, University of British Columbia, Vancouver, British Columbia, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.jtho.2018.12.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6440869PMC
April 2019

How Cancer Genomics Drives Cancer Biology: Does Synthetic Lethality Explain Mutually Exclusive Oncogenic Mutations?

Cold Spring Harb Symp Quant Biol 2016 25;81:247-255. Epub 2017 Jan 25.

BC Cancer Agency and University of British Columbia, Vancouver, British Columbia V5Z 1L3, Canada.

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http://dx.doi.org/10.1101/sqb.2016.81.030866DOI Listing
February 2018

Validation of PAPSS1 (3'-phosphoadenosine 5'-phosphosulfate synthase 1) as a Cisplatin-sensitizing Therapeutic Target.

Clin Cancer Res 2017 Nov 8;23(21):6555-6566. Epub 2017 Aug 8.

Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, Canada.

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http://dx.doi.org/10.1158/1078-0432.CCR-17-0700DOI Listing
November 2017

Expression of the lncRNA Maternally Expressed Gene 3 (MEG3) Contributes to the Control of Lung Cancer Cell Proliferation by the Rb Pathway.

PLoS One 2016 10;11(11):e0166363. Epub 2016 Nov 10.

Department of Biochemistry and Molecular Genetics, James Graham Brown Cancer Center, University of Louisville, Louisville, Kentucky, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0166363PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5104461PMC
June 2017

RASSF1A methylation, YAP1 activation and metastasis: a new role for an old foe in lung cancer.

J Thorac Dis 2017 May;9(5):1165-1167

Department of Integrative Oncology, British Columbia Cancer Agency, Vancouver, Canada.

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http://dx.doi.org/10.21037/jtd.2017.04.16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5465109PMC
May 2017

MIR155 Regulation of Ubiquilin1 and Ubiquilin2: Implications in Cellular Protection and Tumorigenesis.

Neoplasia 2017 04 16;19(4):321-332. Epub 2017 Mar 16.

James Graham Brown Cancer Center, University of Louisville, Louisville, KY 40202; Department of Medicine, Division of Hematology and Oncology, University of Louisville School of Medicine, Louisville, KY 40202; Department of Pharmacology and Toxicology, University of Louisville School of Medicine, Louisville, KY 40202. Electronic address:

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http://dx.doi.org/10.1016/j.neo.2017.02.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5361868PMC
April 2017

Synthetic lethality in lung cancer and translation to clinical therapies.

Mol Cancer 2016 Sep 29;15(1):61. Epub 2016 Sep 29.

Department of Pathology and Laboratory Medicine, University of British Columbia, Rm. G227-2211 Wesbrook Mall, Vancouver, BC, V6T 2B5, Canada.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5041331PMC
http://dx.doi.org/10.1186/s12943-016-0546-yDOI Listing
September 2016

Evidence that synthetic lethality underlies the mutual exclusivity of oncogenic KRAS and EGFR mutations in lung adenocarcinoma.

Elife 2015 Jun 5;4:e06907. Epub 2015 Jun 5.

Cancer Biology Section, Cancer Genetics Branch, National Human Genome Research Institute, Bethesda, United States.

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http://dx.doi.org/10.7554/eLife.06907DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4478584PMC
June 2015

Loss of the Notch effector RBPJ promotes tumorigenesis.

J Exp Med 2015 Jan 15;212(1):37-52. Epub 2014 Dec 15.

Genome Sciences Centre, Integrative Oncology Department, and Department of Pathology and Laboratory Medicine, British Columbia Cancer Agency, Vancouver, British Columbia V5Z 1L3, Canada Genome Sciences Centre, Integrative Oncology Department, and Department of Pathology and Laboratory Medicine, British Columbia Cancer Agency, Vancouver, British Columbia V5Z 1L3, Canada Experimental Medicine Program and Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver V6T 2B5, British Columbia, Canada Experimental Medicine Program and Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver V6T 2B5, British Columbia, Canada

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http://www.imls.uzh.ch/static/CMS_publications/robinson/lite
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http://www.jem.org/lookup/doi/10.1084/jem.20121192
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http://dx.doi.org/10.1084/jem.20121192DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4291530PMC
January 2015

The PIM family of oncoproteins: small kinases with huge implications in myeloid leukemogenesis and as therapeutic targets.

Oncotarget 2014 Sep;5(18):8503-14

James Graham Brown Cancer Center, University of Louisville, Louisville, KY. Department of Medicine, Division of Hematology and Oncology, University of Louisville School of Medicine, Louisville, KY. Department of Pharmacology and Toxicology, University of Louisville School of Medicine, Louisville, KY.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4226700PMC
http://dx.doi.org/10.18632/oncotarget.2330DOI Listing
September 2014

The novel ubiquitin ligase complex, SCF(Fbxw4), interacts with the COP9 signalosome in an F-box dependent manner, is mutated, lost and under-expressed in human cancers.

PLoS One 2013 2;8(5):e63610. Epub 2013 May 2.

Cancer Biology and Genetics Section, Cancer Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0063610PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3642104PMC
December 2013

YEATS4 is a novel oncogene amplified in non-small cell lung cancer that regulates the p53 pathway.

Cancer Res 2013 Dec 29;73(24):7301-12. Epub 2013 Oct 29.

Authors' Affiliations: Integrative Oncology, BC Cancer Research Center, Vancouver, BC, Canada; National Institutes of Health, Bethesda, Maryland; Department of Genetics, Harvard Medical School, Boston, Massachusetts; and Hamon Center of Therapeutics, University of Texas South Western, Dallas, Texas.

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http://dx.doi.org/10.1158/0008-5472.CAN-13-1897DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3959870PMC
December 2013

Sensitivity of human lung adenocarcinoma cell lines to targeted inhibition of BET epigenetic signaling proteins.

Proc Natl Acad Sci U S A 2012 Nov 5;109(47):19408-13. Epub 2012 Nov 5.

Cancer Biology and Genetics Section, Cancer Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA.

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http://www.pnas.org/cgi/doi/10.1073/pnas.1216363109
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http://dx.doi.org/10.1073/pnas.1216363109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3511085PMC
November 2012

Integrative genomics identified RFC3 as an amplified candidate oncogene in esophageal adenocarcinoma.

Clin Cancer Res 2012 Apr 10;18(7):1936-46. Epub 2012 Feb 10.

Integrative Oncology, British Columbia Cancer Research Centre, Vancouver, British Columbia, Canada.

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http://dx.doi.org/10.1158/1078-0432.CCR-11-1431DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3523177PMC
April 2012

Activation of GATA binding protein 6 (GATA6) sustains oncogenic lineage-survival in esophageal adenocarcinoma.

Proc Natl Acad Sci U S A 2012 Mar 28;109(11):4251-6. Epub 2012 Feb 28.

Department of Surgery, Department of Pathology, and Department of Human Genetics, University of Michigan, Ann Arbor, MI 48109, USA.

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http://dx.doi.org/10.1073/pnas.1011989109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3306720PMC
March 2012

Ubiquitination, localization, and stability of an anti-apoptotic BCL2-like protein, BCL2L10/BCLb, are regulated by Ubiquilin1.

Proc Natl Acad Sci U S A 2012 Jan 10;109(3):E119-26. Epub 2012 Jan 10.

Cancer Biology and Genetics Section, Cancer Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1073/pnas.1119167109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3271887PMC
January 2012

miR-101 DNA copy loss is a prominent subtype specific event in lung cancer.

J Thorac Oncol 2011 Sep;6(9):1594-8

BC Cancer Research Centre, Vancouver, British Columbia, Canada.

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http://dx.doi.org/10.1097/JTO.0b013e3182217d81DOI Listing
September 2011

Superoxide dismutase 1 (SOD1) is a target for a small molecule identified in a screen for inhibitors of the growth of lung adenocarcinoma cell lines.

Proc Natl Acad Sci U S A 2011 Sep 19;108(39):16375-80. Epub 2011 Sep 19.

High Throughput Screening Core Facility, and Organic Synthesis Core Facility, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA. or

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http://dx.doi.org/10.1073/pnas.1113554108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3182729PMC
September 2011

Lung cancer cell lines as tools for biomedical discovery and research.

J Natl Cancer Inst 2010 Sep 2;102(17):1310-21. Epub 2010 Aug 2.

University of Texas Southwestern Medical Center, 6000 Harry Hines Blvd, Dallas, TX 75390-8593, USA.

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https://academic.oup.com/jnci/article-lookup/doi/10.1093/jnc
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http://dx.doi.org/10.1093/jnci/djq279DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2935474PMC
September 2010

An integrative multi-dimensional genetic and epigenetic strategy to identify aberrant genes and pathways in cancer.

BMC Syst Biol 2010 May 17;4:67. Epub 2010 May 17.

Department of Integrative Oncology, BC Cancer Research Centre, Vancouver, BC, Canada.

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http://dx.doi.org/10.1186/1752-0509-4-67DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2880289PMC
May 2010

Comparative genomic hybridization on BAC arrays.

Methods Mol Biol 2009 ;556:7-19

British Columbia Cancer Research Centre, BC, Canada.

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http://link.springer.com/10.1007/978-1-60327-192-9_2
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http://dx.doi.org/10.1007/978-1-60327-192-9_2DOI Listing
September 2009

Evolving strategies for global gene expression analysis of cancer.

J Cell Physiol 2008 Dec;217(3):590-7

British Columbia Cancer Research Centre, Vancouver, British Columbia, Canada.

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http://dx.doi.org/10.1002/jcp.21554DOI Listing
December 2008

Integrative genomic and gene expression analysis of chromosome 7 identified novel oncogene loci in non-small cell lung cancer.

Genome 2008 Dec;51(12):1032-9

Department of Cancer Genetics and Developmental Biology, British Columbia Cancer Research Centre, 675 West 10th Avenue, Vancouver, BC V5Z1L3 Canada.

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http://dx.doi.org/10.1139/G08-086DOI Listing
December 2008

PIK3CA mutations and copy number gains in human lung cancers.

Cancer Res 2008 Sep;68(17):6913-21

Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center at Dallas, 6000 Harry Hines Boulevard, Dallas, TX 75390-8593, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-07-5084DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2874836PMC
September 2008

Genomic analyses identify gene candidates for acquired irinotecan resistance in melanoma cells.

Int J Oncol 2008 Jun;32(6):1343-9

Department of Dermatology and Skin Science, Jack Bell Research Centre, Vancouver Coastal Health Research Institute, University of British Columbia, Vancouver, Canada.

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http://dx.doi.org/10.3892/ijo_32_6_1343DOI Listing
June 2008

Computational methods for the analysis of array comparative genomic hybridization.

Cancer Inform 2007 Feb 10;2:48-58. Epub 2007 Feb 10.

Cancer Genetics and Developmental Biology, British Columbia Cancer Research Centre, Vancouver BC, Canada V5Z 1L3.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2067254PMC
February 2007

Whole genome tiling path array CGH analysis of segmental copy number alterations in cervical cancer cell lines.

Int J Cancer 2007 Jan;120(2):436-43

Department of Cancer Genetics and Developmental Biology, British Columbia Cancer Research Centre, Vancouver, BC, Canada.

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http://dx.doi.org/10.1002/ijc.22335DOI Listing
January 2007

Recent advances in array comparative genomic hybridization technologies and their applications in human genetics.

Eur J Hum Genet 2006 Feb;14(2):139-48

Cancer Genetics and Developmental Biology, British Columbia Cancer Research Centre, Vancouver BC, Canada V5Z 1L3.

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http://dx.doi.org/10.1038/sj.ejhg.5201531DOI Listing
February 2006