William Valdar

William Valdar

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William Valdar

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Integrative QTL analysis of gene expression and chromatin accessibility identifies multi-tissue patterns of genetic regulation.

PLoS Genet 2020 Jan 21;16(1):e1008537. Epub 2020 Jan 21.

Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America.

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http://dx.doi.org/10.1371/journal.pgen.1008537DOI Listing
January 2020

Determinants of QTL Mapping Power in the Realized Collaborative Cross.

G3 (Bethesda) 2019 05 7;9(5):1707-1727. Epub 2019 May 7.

Department of Genetics, University of North Carolina, Chapel Hill, North Carolina 27599

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http://dx.doi.org/10.1534/g3.119.400194DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6505132PMC
May 2019

Impact of vitamin D depletion during development on mouse sperm DNA methylation.

Epigenetics 2018 21;13(9):959-974. Epub 2018 Oct 21.

a Department of Genetics, School of Medicine , University of North Carolina at Chapel Hill , Chapel Hill , NC , USA.

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http://dx.doi.org/10.1080/15592294.2018.1526027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6284778PMC
March 2019

QTL Mapping on a Background of Variance Heterogeneity.

G3 (Bethesda) 2018 12 10;8(12):3767-3782. Epub 2018 Dec 10.

Department of Genetics

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http://g3journal.org/lookup/doi/10.1534/g3.118.200790
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http://dx.doi.org/10.1534/g3.118.200790DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6288843PMC
December 2018

vqtl: An R Package for Mean-Variance QTL Mapping.

G3 (Bethesda) 2018 12 10;8(12):3757-3766. Epub 2018 Dec 10.

Department of Genetics

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http://g3journal.org/lookup/doi/10.1534/g3.118.200642
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http://dx.doi.org/10.1534/g3.118.200642DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6288833PMC
December 2018

Dissecting the Genetic Architecture of Shoot Growth in Carrot ( L.) Using a Diallel Mating Design.

G3 (Bethesda) 2018 02 2;8(2):411-426. Epub 2018 Feb 2.

Department of Horticulture, University of Wisconsin-Madison, Wisconsin 53706

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http://g3journal.org/lookup/doi/10.1534/g3.117.300235
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http://dx.doi.org/10.1534/g3.117.300235DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5919754PMC
February 2018

Maternal vitamin D depletion alters DNA methylation at imprinted loci in multiple generations.

Clin Epigenetics 2016 12;8:107. Epub 2016 Oct 12.

Nutrition Research Institute, University of North Carolina, Kannapolis, NC 28081 USA ; Department of Genetics, School of Medicine, University of North Carolina, Chapel Hill, NC 27599 USA ; Department of Nutrition, Gillings School of Public Health, University of North Carolina, Chapel Hill, NC 27599 USA.

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http://dx.doi.org/10.1186/s13148-016-0276-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5062906PMC
April 2017

Ovariectomy results in inbred strain-specific increases in anxiety-like behavior in mice.

Physiol Behav 2016 12 29;167:404-412. Epub 2016 Sep 29.

Department of Genetics, School of Medicine, University of North Carolina, Chapel Hill, NC, United States; Department of Psychiatry, School of Medicine, University of North Carolina, Chapel Hill, NC, United States; Division of Pharmacotherapy and Experimental Therapeutics, Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC, United States. Electronic address:

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http://dx.doi.org/10.1016/j.physbeh.2016.09.026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5289389PMC
December 2016

Joint Estimation of Multiple Dependent Gaussian Graphical Models with Applications to Mouse Genomics.

Biometrika 2016 09;103(3):493-511

Department of Genetics, University of North Carolina, Chapel Hill, North Carolina 27599, U.S.A.

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http://dx.doi.org/10.1093/biomet/asw035DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5640885PMC
September 2016

A permutation approach for selecting the penalty parameter in penalized model selection.

Biometrics 2015 Dec 3;71(4):1185-94. Epub 2015 Aug 3.

Department of Statistics and Operations Research, University of North Carolina at Chapel Hill, North Carolina, U.S.A.

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http://dx.doi.org/10.1111/biom.12359DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4715654PMC
December 2015

Genome- and exome-wide association study of serum lipoprotein (a) in the Jackson Heart Study.

J Hum Genet 2015 Dec 17;60(12):755-61. Epub 2015 Sep 17.

Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

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http://dx.doi.org/10.1038/jhg.2015.107DOI Listing
December 2015

Plasma Levels of Soluble Interleukin-2 Receptor α: Associations With Clinical Cardiovascular Events and Genome-Wide Association Scan.

Arterioscler Thromb Vasc Biol 2015 Oct 20;35(10):2246-53. Epub 2015 Aug 20.

From the Departments of Pathology (P.D., N.S.J., M.C., R.P.T.), Medicine (M.C.), and Biochemistry (R.P.T.), University of Vermont College of Medicine, Burlington; Departments of Genetics (J.S., E.M.L., J.L., W.V., L.A.L.), Biostatistics (E.M.L., W.V.), Lineberger Comprehensive Cancer Center, School of Medicine (J.S., E.M.L., W.V.), University of North Carolina, Chapel Hill; Laboratory of Neurogenetics, Porter Neuroscience Research Center, National Institute on Aging, National Institute of Health, Bethesda, MD (M.A.N.); Center for Public Health Genomics, School of Medicine, University of Virginia, Charlottesville (J.C.M.); Johns Hopkins Medical Institutions, Department of Medicine Geriatrics, Johns Hopkins University, John R. Burton Pavilion, Baltimore, MD (J.D.W.); Geriatric Epidemiology Section, National Institute on Aging, National Institute of Health, Bethesda, MD (T.B.H.); Cardiovascular Health Research Unit (B.M.P.), Departments of Medicine (B.M.P.) and Epidemiology (B.M.P., A.P.R.), University of Washington, Seattle; Group Health Research Institute, Division of Cardiology, Group Health Cooperative, Seattle, WA (B.M.P.); and Wake Forest University School of Medicine, Center for Genomics and Personalized Medicine Research, Winston-Salem, NC (Y.L.).

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http://dx.doi.org/10.1161/ATVBAHA.115.305289DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5395092PMC
October 2015

Fine-mapping additive and dominant SNP effects using group-LASSO and fractional resample model averaging.

Genet Epidemiol 2015 Feb 21;39(2):77-88. Epub 2014 Nov 21.

Department of Genetics, University of North Carolina at Chapel Hill, North Carolina, United States of America; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, North Carolina, United States of America.

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http://dx.doi.org/10.1002/gepi.21869DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4314429PMC
February 2015

Bayesian modeling of haplotype effects in multiparent populations.

Genetics 2014 Sep;198(1):139-56

Department of Genetics and Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina 27599

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http://dx.doi.org/10.1534/genetics.114.166249DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4174926PMC
September 2014

Genetic architecture of skewed X inactivation in the laboratory mouse.

PLoS Genet 2013 3;9(10):e1003853. Epub 2013 Oct 3.

Department of Genetics, University of North Carolina, Chapel Hill, North Carolina, United States of America ; Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina, United States of America ; Carolina Center for Genome Sciences, University of North Carolina, Chapel Hill, North Carolina, United States of America ; Curriculum in Genetics and Molecular Biology, University of North Carolina, Chapel Hill, North Carolina, United States of America.

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http://dx.doi.org/10.1371/journal.pgen.1003853DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3789830PMC
March 2014

Fine-mapping diabetes-related traits, including insulin resistance, in heterogeneous stock rats.

Physiol Genomics 2012 Nov 4;44(21):1013-26. Epub 2012 Sep 4.

Department of Pediatrics, Human and Molecular Genetics Center and Children's Research Institute, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA.

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http://dx.doi.org/10.1152/physiolgenomics.00040.2012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3524769PMC
November 2012

Reprioritizing genetic associations in hit regions using LASSO-based resample model averaging.

Genet Epidemiol 2012 Jul 30;36(5):451-62. Epub 2012 Apr 30.

Department of Genetics, and Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599-7265, USA.

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http://doi.wiley.com/10.1002/gepi.21639
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http://dx.doi.org/10.1002/gepi.21639DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3470705PMC
July 2012

Recent developments in statistical methods for detecting genetic loci affecting phenotypic variability.

BMC Genet 2012 Jul 24;13:63. Epub 2012 Jul 24.

Statistics Unit, Dalarna University, SE-781 70 Borlänge, Sweden.

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http://dx.doi.org/10.1186/1471-2156-13-63DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3493319PMC
July 2012

A general Bayesian approach to analyzing diallel crosses of inbred strains.

Genetics 2012 Feb;190(2):413-35

Department of Genetics and Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina 27599-7265, USA.

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http://dx.doi.org/10.1534/genetics.111.132563DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3276624PMC
February 2012

Genome-wide and species-wide dissection of the genetics of arthritis severity in heterogeneous stock mice.

Arthritis Rheum 2011 Sep;63(9):2630-40

Joslin Diabetes Center and Brigham and Women's Hospital, and Harvard Medical School, Boston, Massachusetts 02115, USA.

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http://doi.wiley.com/10.1002/art.30425
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http://dx.doi.org/10.1002/art.30425DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3371645PMC
September 2011

High-resolution mapping of a complex disease, a model for rheumatoid arthritis, using heterogeneous stock mice.

Hum Mol Genet 2011 Aug 12;20(15):3031-41. Epub 2011 May 12.

Division of Medical Inflammation Research, Department of Medical Biochemistry, Biophysics Karolinska Institute, 17177 Stockholm, Sweden.

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http://dx.doi.org/10.1093/hmg/ddr206DOI Listing
August 2011

Detecting major genetic loci controlling phenotypic variability in experimental crosses.

Genetics 2011 Jun 5;188(2):435-47. Epub 2011 Apr 5.

Statistics Unit, Dalarna University, Borlänge, Sweden.

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http://dx.doi.org/10.1534/genetics.111.127068DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3122324PMC
June 2011

Fine-mapping a locus for glucose tolerance using heterogeneous stock rats.

Physiol Genomics 2010 Mar 12;41(1):102-8. Epub 2010 Jan 12.

Human and Molecular Genetics Center, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA.

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http://dx.doi.org/10.1152/physiolgenomics.00178.2009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2841497PMC
March 2010

Unlearned anxiety predicts learned fear: a comparison among heterogeneous rats and the Roman rat strains.

Behav Brain Res 2009 Aug 28;202(1):92-101. Epub 2009 Mar 28.

Department of Psychiatry & Forensic Medicine, Institute of Neurosciences, School of Medicine, Autonomous University of Barcelona, Barcelona, Spain.

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http://dx.doi.org/10.1016/j.bbr.2009.03.024DOI Listing
August 2009

Mapping in structured populations by resample model averaging.

Genetics 2009 Aug 27;182(4):1263-77. Epub 2009 May 27.

Wellcome Trust Centre for Human Genetics, Roosevelt Dr., Oxford OX3 7BN, United Kingdom.

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http://dx.doi.org/10.1534/genetics.109.100727DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2728864PMC
August 2009

Association of infectious mononucleosis with multiple sclerosis. A population-based study.

Neuroepidemiology 2009 11;32(4):257-62. Epub 2009 Feb 11.

Wellcome Trust Centre for Human Genetics, Oxford, UK.

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http://dx.doi.org/10.1159/000201564DOI Listing
June 2009

No effect of birth weight on the risk of multiple sclerosis. A population-based study.

Neuroepidemiology 2008 11;31(3):181-4. Epub 2008 Sep 11.

Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.

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https://www.karger.com/Article/FullText/154931
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http://dx.doi.org/10.1159/000154931DOI Listing
February 2009

Deciphering gene-environment interactions through mouse models of allergic asthma.

J Allergy Clin Immunol 2009 Jan 16;123(1):14-23; quiz 24-5. Epub 2008 Oct 16.

National Heart and Lung Institute, London, United Kingdom.

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http://linkinghub.elsevier.com/retrieve/pii/S009167490801677
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http://dx.doi.org/10.1016/j.jaci.2008.09.016DOI Listing
January 2009

No effect of preterm birth on the risk of multiple sclerosis: a population based study.

BMC Neurol 2008 Aug 1;8:30. Epub 2008 Aug 1.

Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Headington, Oxford, OX3 7BN, UK.

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http://dx.doi.org/10.1186/1471-2377-8-30DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2518551PMC
August 2008

Fearfulness in a large N/Nih genetically heterogeneous rat stock: differential profiles of timidity and defensive flight in males and females.

Behav Brain Res 2008 Mar 26;188(1):41-55. Epub 2007 Oct 26.

Medical Psychology Unit, Department of Psychiatry & Forensic Medicine, Institute of Neurosciences, School of Medicine, Autonomous University of Barcelona, 08193 Bellaterra, Barcelona, Spain.

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http://dx.doi.org/10.1016/j.bbr.2007.10.015DOI Listing
March 2008

Management, presentation and interpretation of genome scans using GSCANDB.

Bioinformatics 2007 Jun 30;23(12):1545-9. Epub 2007 Mar 30.

Wellcome Trust Centre for Human Genetics, Oxford, UK.

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http://dx.doi.org/10.1093/bioinformatics/btm123DOI Listing
June 2007

Estimating the number of coding mutations in genotypic and phenotypic driven N-ethyl-N-nitrosourea (ENU) screens: revisited.

Mamm Genome 2007 Feb 8;18(2):123-4. Epub 2007 Mar 8.

Psychiatric Genetics Laboratory, Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford, OX3 7BN, United Kingdom.

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http://dx.doi.org/10.1007/s00335-006-0065-zDOI Listing
February 2007

Sex ratio of multiple sclerosis in Canada: a longitudinal study.

Lancet Neurol 2006 Nov;5(11):932-6

Wellcome Trust Centre for Human Genetics and Department of Clinical Neurology, University of Oxford, Oxford, UK.

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http://dx.doi.org/10.1016/S1474-4422(06)70581-6DOI Listing
November 2006

Genetic and environmental effects on complex traits in mice.

Genetics 2006 Oct 3;174(2):959-84. Epub 2006 Aug 3.

Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom.

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http://dx.doi.org/10.1534/genetics.106.060004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1602068PMC
October 2006

Genome-wide genetic association of complex traits in heterogeneous stock mice.

Nat Genet 2006 Aug 9;38(8):879-87. Epub 2006 Jul 9.

Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK.

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http://dx.doi.org/10.1038/ng1840DOI Listing
August 2006

Simulating the collaborative cross: power of quantitative trait loci detection and mapping resolution in large sets of recombinant inbred strains of mice.

Genetics 2006 Mar 15;172(3):1783-97. Epub 2005 Dec 15.

Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, United Kingdom.

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http://dx.doi.org/10.1534/genetics.104.039313DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1456308PMC
March 2006

Strategies for mapping and cloning quantitative trait genes in rodents.

Nat Rev Genet 2005 Apr;6(4):271-86

Wellcome Trust Centre for Human Genetics, Oxford University, Roosevelt Drive, Oxford OX3 7BN, United Kingdom.

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http://dx.doi.org/10.1038/nrg1576DOI Listing
April 2005

The Collaborative Cross, a community resource for the genetic analysis of complex traits.

Authors:
Gary A Churchill David C Airey Hooman Allayee Joe M Angel Alan D Attie Jackson Beatty William D Beavis John K Belknap Beth Bennett Wade Berrettini Andre Bleich Molly Bogue Karl W Broman Kari J Buck Ed Buckler Margit Burmeister Elissa J Chesler James M Cheverud Steven Clapcote Melloni N Cook Roger D Cox John C Crabbe Wim E Crusio Ariel Darvasi Christian F Deschepper R W Doerge Charles R Farber Jiri Forejt Daniel Gaile Steven J Garlow Hartmut Geiger Howard Gershenfeld Terry Gordon Jing Gu Weikuan Gu Gerald de Haan Nancy L Hayes Craig Heller Heinz Himmelbauer Robert Hitzemann Kent Hunter Hui-Chen Hsu Fuad A Iraqi Boris Ivandic Howard J Jacob Ritsert C Jansen Karl J Jepsen Dabney K Johnson Thomas E Johnson Gerd Kempermann Christina Kendziorski Malak Kotb R Frank Kooy Bastien Llamas Frank Lammert Jean-Michel Lassalle Pedro R Lowenstein Lu Lu Aldons Lusis Kenneth F Manly Ralph Marcucio Doug Matthews Juan F Medrano Darla R Miller Guy Mittleman Beverly A Mock Jeffrey S Mogil Xavier Montagutelli Grant Morahan David G Morris Richard Mott Joseph H Nadeau Hiroki Nagase Richard S Nowakowski Bruce F O'Hara Alexander V Osadchuk Grier P Page Beverly Paigen Kenneth Paigen Abraham A Palmer Huei-Ju Pan Leena Peltonen-Palotie Jeremy Peirce Daniel Pomp Michal Pravenec Daniel R Prows Zhonghua Qi Roger H Reeves John Roder Glenn D Rosen Eric E Schadt Leonard C Schalkwyk Ze'ev Seltzer Kazuhiro Shimomura Siming Shou Mikko J Sillanpää Linda D Siracusa Hans-Willem Snoeck Jimmy L Spearow Karen Svenson Lisa M Tarantino David Threadgill Linda A Toth William Valdar Fernando Pardo-Manuel de Villena Craig Warden Steve Whatley Robert W Williams Tim Wiltshire Nengjun Yi Dabao Zhang Min Zhang Fei Zou

Nat Genet 2004 Nov;36(11):1133-7

The Jackson Laboratory, 600 Main Street Bar Harbor, Maine 04609, USA.

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http://dx.doi.org/10.1038/ng1104-1133DOI Listing
November 2004

QTL fine-mapping with recombinant-inbred heterogeneous stocks and in vitro heterogeneous stocks.

Mamm Genome 2003 Dec;14(12):830-8

Wellcome Trust Centre for Human Genetics, Roosevelt Drive, Oxford OX4 7AD, UK.

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http://dx.doi.org/10.1007/s00335-003-3021-1DOI Listing
December 2003

Scoring residue conservation.

Proteins 2002 Aug;48(2):227-41

Biomolecular Structure and Modelling Unit, Department of Biochemistry and Molecular Biology, University College London, London, United Kingdom.

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http://doi.wiley.com/10.1002/prot.10146
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http://dx.doi.org/10.1002/prot.10146DOI Listing
August 2002