William Vainchenker

William Vainchenker

UNVERIFIED PROFILE

Are you William Vainchenker?   Register this Author

Register author
William Vainchenker

William Vainchenker

Publications by authors named "William Vainchenker"

Are you William Vainchenker?   Register this Author

100Publications

3123Reads

7Profile Views

TET2 haploinsufficiency alters reprogramming into induced pluripotent stem cells.

Stem Cell Res 2020 Mar 6;44:101755. Epub 2020 Mar 6.

INSERM, UMR 1170, Laboratory of Excellence GR-Ex, Villejuif, France; Université Paris XI, UMR 1170, Gustave Roussy, Villejuif, France; UMR U1170,Gustave Roussy, 114 rue Edouard Vaillant, Villejuif 94805, France; Laboratory of Excellence GR-Ex, Villejuif, France. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.scr.2020.101755DOI Listing
March 2020

Immunosuppression by Mutated Calreticulin Released from Malignant Cells.

Mol Cell 2020 02 27;77(4):748-760.e9. Epub 2019 Nov 27.

Metabolomics and Cell Biology Platforms, Gustave Roussy Comprehensive Cancer Institute, Villejuif, France; Equipe 11 labellisée Ligue contre le Cancer, Centre de Recherche des Cordeliers, INSERM UMR 1138, Paris, France; Sorbonne Université, Paris, France; Université of Paris, Paris, France; Suzhou Institute for Systems Medicine, Chinese Academy of Sciences, Suzhou, China; Karolinska Institutet, Department of Women's and Children's Health, Stockholm, Sweden; Pôle de Biologie, Hôpital Européen Georges Pompidou, AP-HP, Paris, France. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.molcel.2019.11.004DOI Listing
February 2020

Remodeling of Bone Marrow Hematopoietic Stem Cell Niches Promotes Myeloid Cell Expansion during Premature or Physiological Aging.

Cell Stem Cell 2019 Sep 11;25(3):407-418.e6. Epub 2019 Jul 11.

Wellcome Trust-Medical Research Council Cambridge Stem Cell Institute and Department of Haematology, University of Cambridge, Cambridge CB2 0PT, UK; National Health Service Blood and Transplant, Cambridge Biomedical Campus, Cambridge CB2 0PT, UK; Centro Nacional de Investigaciones Cardiovasculares (CNIC), 28029 Madrid, Spain. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.stem.2019.06.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6739444PMC
September 2019

MCM8- and MCM9 Deficiencies Cause Lifelong Increased Hematopoietic DNA Damage Driving p53-Dependent Myeloid Tumors.

Cell Rep 2019 Sep;28(11):2851-2865.e4

Institute of Human Genetics, CNRS, DNA Replication and Genome Dynamics, 141, Rue de la Cardonille, 34396 Montpellier, France; Institute of Human Genetics, UMR 9002, CNRS-University of Montpellier, 141, Rue de la Cardonille, 34396 Montpellier, France. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.celrep.2019.07.095DOI Listing
September 2019

Megakaryocyte polyploidization: role in platelet production.

Platelets 2019 Sep 22:1-10. Epub 2019 Sep 22.

UMR 1170, Institut National de la Santé et de la Recherche Médicale, Univ. Paris-Sud, Université Paris-Saclay, Gustave Roussy Cancer Campus, Equipe Labellisée Ligue Nationale Contre le Cancer , Villejuif , France.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/09537104.2019.1667497DOI Listing
September 2019

The role of the thrombopoietin receptor MPL in myeloproliferative neoplasms: recent findings and potential therapeutic applications.

Expert Rev Hematol 2019 06 22;12(6):437-448. Epub 2019 May 22.

c Ludwig Institute for Cancer Research Brussels , Brussels , Belgium.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/17474086.2019.1617129DOI Listing
June 2019

Disrupted filamin A/αβ interaction induces macrothrombocytopenia by increasing RhoA activity.

Blood 2019 04 2;133(16):1778-1788. Epub 2019 Jan 2.

Unité Mixte de Recherche (UMR) 1170, INSERM, Equipe Labelllisée Ligue Nationale Contre le Cancer, Gustave Roussy Cancer Campus, Université Paris-Sud, Université Paris-Saclay, Villejuif, France.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1182/blood-2018-07-861427DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6484462PMC
April 2019

Megakaryocyte and polyploidization.

Exp Hematol 2018 01 27;57:1-13. Epub 2017 Oct 27.

INSERM UMR1170, Equipe labellisée LNNC, Gustave Roussy, Villejuif, France; Université Paris Saclay, UMR1170, Gustave Roussy, France; Université Paris-Diderot, Paris, France; Institut National de la Transfusion Sanguine, Paris, France. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.exphem.2017.10.001DOI Listing
January 2018

JAK inhibitors for the treatment of myeloproliferative neoplasms and other disorders.

F1000Res 2018 17;7:82. Epub 2018 Jan 17.

Signal Transduction & Molecular Hematology Unit, Ludwig Institute for Cancer Research, Brussels, Belgium.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.12688/f1000research.13167.1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5773931PMC
January 2018

CK2: a key regulator of thrombopoiesis.

Blood 2017 12;130(25):2695-2697

INSERM; GUSTAVE ROUSSY; UNIVERSITÉ PARIS-SACLAY.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1182/blood-2017-10-808568DOI Listing
December 2017

Identification of R102P Mutation in Hereditary Thrombocytosis.

Front Endocrinol (Lausanne) 2017 20;8:235. Epub 2017 Sep 20.

INSERM UMR1170, Gustave Roussy, Villejuif, France.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fendo.2017.00235DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5611484PMC
September 2017

Non-apoptotic functions of caspases in myeloid cell differentiation.

Cell Death Differ 2017 08 17;24(8):1337-1347. Epub 2017 Feb 17.

Inserm U1170, Université Paris-Sud, Faculté de Médecine Paris-Sud, Gustave Roussy, Villejuif, France.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/cdd.2017.19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5520450PMC
August 2017

Genetic basis and molecular pathophysiology of classical myeloproliferative neoplasms.

Blood 2017 02 27;129(6):667-679. Epub 2016 Dec 27.

Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1182/blood-2016-10-695940DOI Listing
February 2017

Uncoupling of the Hippo and Rho pathways allows megakaryocytes to escape the tetraploid checkpoint.

Haematologica 2016 12 11;101(12):1469-1478. Epub 2016 Aug 11.

Institut National de la Santé et la Recherche Médicale (INSERM) UMR1170, Equipe Labellisée par la Ligue Nationale Contre le Cancer, Villejuif, France

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3324/haematol.2016.149914DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5479626PMC
December 2016

Activity of nonmuscle myosin II isoforms determines localization at the cleavage furrow of megakaryocytes.

Blood 2016 12 13;128(26):3137-3145. Epub 2016 Oct 13.

Institut National de la Santé et de la Recherche Médicale, Unité mixte de recherche (UMR) 1170, Villejuif, France.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1182/blood-2016-04-711630DOI Listing
December 2016

Eltrombopag, a potent stimulator of megakaryopoiesis.

Haematologica 2016 12;101(12):1443-1445

INSERM, UMR1170, Gustave Roussy, Villejuif, France

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3324/haematol.2016.153668DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5479610PMC
December 2016

TET2-mediated 5-hydroxymethylcytosine induces genetic instability and mutagenesis.

DNA Repair (Amst) 2016 07 24;43:78-88. Epub 2016 May 24.

INSERM, UMR 1170, Laboratory of Excellence GR-Ex, Villejuif, France; Université Paris XI, UMR 1170, Gustave Roussy, Villejuif, France; Gustave Roussy, Villejuif, France; Laboratory of Excellence GR-Ex, Villejuif, France. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.dnarep.2016.05.031DOI Listing
July 2016

EZH2: a molecular switch of the MPN phenotype.

Blood 2016 06;127(26):3297-8

INSERM.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1182/blood-2016-04-711770DOI Listing
June 2016

[Not Available].

Bull Cancer 2016 Jun;103(6 Suppl 1):S16-28

Inserm UMR 1170, Gustave Roussy, Villejuif, 94805, France; Université Paris-Saclay, UMR 1170, Gustave Roussy, Villejuif, 94805, France; Gustave Roussy, UMR 1170, Villejuif, 94805, France. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/S0007-4551(16)30142-4DOI Listing
June 2016

Recent advances in understanding myelofibrosis and essential thrombocythemia.

F1000Res 2016 19;5. Epub 2016 Apr 19.

Gustave Roussy, Paris, France; Universite Paris-Saclay, Gustave Roussy, Paris, France.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.12688/f1000research.8081.1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4841197PMC
May 2016

ATG2B and GSKIP: 2 new genes predisposing to myeloid malignancies.

Mol Cell Oncol 2016 Mar 29;3(2):e1094564. Epub 2015 Oct 29.

INSERM, UMR 1170, Gustave Roussy, Villejuif, France; Université Paris-Sud, UMR1170, Gustave Roussy, Villejuif, France; Gustave Roussy, Villejuif France.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/23723556.2015.1094564DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905402PMC
March 2016

Presence of atypical thrombopoietin receptor (MPL) mutations in triple-negative essential thrombocythemia patients.

Blood 2016 Jan 8;127(3):333-42. Epub 2015 Oct 8.

INSERM, Unité Mixte de Recherche (UMR) 1170, Gustave Roussy, Villejuif, France; Université Paris-Saclay, UMR1170, Gustave Roussy, Villejuif, France; UMR1170, Gustave Roussy, Villejuif, France; Consultation d'Hématologie-Immunologie, Hôpital Saint Louis, Assistance Publique-Hôpitaux de Paris, Paris, France.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1182/blood-2015-07-661983DOI Listing
January 2016

JAK2 inhibition has different therapeutic effects according to myeloproliferative neoplasm development in mice.

J Cell Mol Med 2015 Nov 14;19(11):2564-74. Epub 2015 Jul 14.

Inserm, U.1009, Institut Gustave Roussy (IGR), Université Paris XI, Villejuif, France.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/jcmm.12608DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4627562PMC
November 2015

Concise Review: Induced Pluripotent Stem Cells as New Model Systems in Oncology.

Stem Cells 2015 Oct 29;33(10):2887-92. Epub 2015 Jul 29.

Gustave Roussy Cancer Center, Villejuif, Paris, France.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/stem.2099DOI Listing
October 2015

[Properties and biological roles of TET proteins during embryogenesis and in hematopoiesis].

Med Sci (Paris) 2015 Mar 8;31(3):268-74. Epub 2015 Apr 8.

Inserm 1170, Institut Gustave Roussy, 114, rue Edouard Vaillant, 94805 Villejuif, France - Institut Gustave Roussy, Villejuif, France - Université Paris XI, Orsay, France.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1051/medsci/20153103012DOI Listing
March 2015

A CALR mutation preceding BCR-ABL1 in an atypical myeloproliferative neoplasm.

N Engl J Med 2015 Feb;372(7):688-90

INSERM Unité 1009, Villejuif, France.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1056/NEJMc1413718DOI Listing
February 2015

TET2 loss, a rescue of JAK2V617F HSCs.

Blood 2015 Jan;125(2):212-3

INSTITUT DE CANCÉROLOGIE GUSTAVE ROUSSY.

View Article

Download full-text PDF

Source
http://www.bloodjournal.org/cgi/doi/10.1182/blood-2014-10-60
Publisher Site
http://dx.doi.org/10.1182/blood-2014-10-606624DOI Listing
January 2015

Defective endomitosis during megakaryopoiesis leads to thrombocytopenia in Fanca-/- mice.

Blood 2014 Dec 26;124(24):3613-23. Epub 2014 Sep 26.

Université Paris Sud, Orsay, France; Centre national de la recherche scientifique UMR 8200, Institut de Cancérologie Gustave Roussy, Villejuif, France; Equipe Labellisée par La Ligue Contre le Cancer; Institut de Cancérologie Gustave Roussy, Villejuif, France;

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1182/blood-2014-01-551457DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4256912PMC
December 2014

The formin DIAPH1 (mDia1) regulates megakaryocyte proplatelet formation by remodeling the actin and microtubule cytoskeletons.

Blood 2014 Dec 8;124(26):3967-77. Epub 2014 Oct 8.

Institut National de la Santé et de la Recherche Médicale Unité 1009, Institut Gustave Roussy, Villejuif, France; Institut Gustave Roussy, Plateforme Imagerie et Cytométrie, Villejuif, France; Université Paris-Sud, Le Kremlin-Bicêtre, France;

View Article

Download full-text PDF

Source
http://www.bloodjournal.org/cgi/doi/10.1182/blood-2013-12-54
Publisher Site
http://dx.doi.org/10.1182/blood-2013-12-544924DOI Listing
December 2014

p19 INK4d controls hematopoietic stem cells in a cell-autonomous manner during genotoxic stress and through the microenvironment during aging.

Stem Cell Reports 2014 Dec 20;3(6):1085-102. Epub 2014 Nov 20.

Institut National de la Santé et de la Recherche Médicale, U1009, Equipe labellisée Ligue Nationale contre le Cancer, 114 rue Edouard Vaillant, 94805 Villejuif, France; University Paris Sud, 114, rue Edouard Vaillant, 94805 Villejuif, France; Gustave Roussy, IFR54, 114, rue Edouard Vaillant, 94805 Villejuif, France. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.stemcr.2014.10.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4264042PMC
December 2014

Carboxyl-terminal-dependent recruitment of nonmuscle myosin II to megakaryocyte contractile ring during polyploidization.

Blood 2014 Oct 2;124(16):2564-8. Epub 2014 Sep 2.

INSERM UMR1009, Institut Gustave Roussy, Villejuif, France; Université Paris-Sud, Unité Mixte de Recherche 1009, Le Kremlin-Bicêtre, France; Institut Gustave Roussy, Unité Mixte de Recherche 1009, Villejuif, France; and.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1182/blood-2014-06-584995DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4199958PMC
October 2014

JAK2 and MPL protein levels determine TPO-induced megakaryocyte proliferation vs differentiation.

Blood 2014 Sep 20;124(13):2104-15. Epub 2014 Aug 20.

INSERM Unité Mixte de Recherche 1009, Villejuif, France; Integrated Research Cancer Institute in Villejuif, Villejuif, France; Assistance Publique-Hôpitaux de Paris, Hématologie Biologique, Hôpital Henri-Mondor, Créteil, France; Faculty of Medicine, University Paris-12, Créteil, France;

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1182/blood-2014-03-559815DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4186539PMC
September 2014

Myeloproliferative neoplasms: JAK2 signaling pathway as a central target for therapy.

Clin Lymphoma Myeloma Leuk 2014 Sep;14 Suppl:S23-35

INSERM 1009, Institut Gustave Roussy, Villejuif, France; Institut Gustave Roussy, Villejuif, France; Université Paris XI, Institut Gustave Roussy, Villejuif, France; Ligue Nationale contre le Cancer, équipe labellisée, Villejuif, France. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.clml.2014.06.014DOI Listing
September 2014

TET2 deficiency inhibits mesoderm and hematopoietic differentiation in human embryonic stem cells.

Stem Cells 2014 Aug;32(8):2084-97

Institut National de la Santé et de la Recherche Médicale, UMR 1009, Laboratory of Excellence GR-Ex, 114 rue Edouard Vaillant, Villejuif, Paris, France; Institut Gustave Roussy, Villejuif, Paris, France; Université Paris Sud 11, Orsay, France.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/stem.1718DOI Listing
August 2014

Emergence of a BCR-ABL translocation in a patient with the JAK2V617F mutation: evidence for secondary acquisition of BCR-ABL in the JAK2V617F clone.

J Clin Oncol 2014 Jul 10;32(21):e76-9. Epub 2014 Feb 10.

INSERM, UMR 1009, Institut Gustave Roussy, Université Paris XI; INSERM, UMR 1009, Laboratoire d'Excellence du Globule Rouge, Villejuif, France.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1200/JCO.2012.47.8669DOI Listing
July 2014

Heterozygous and homozygous JAK2(V617F) states modeled by induced pluripotent stem cells from myeloproliferative neoplasm patients.

PLoS One 2013 16;8(9):e74257. Epub 2013 Sep 16.

Institut National de la Santé et de la Recherche Médicale, Unité Mixte de Recherche 1009, Laboratory of Excellence, Globule rouge-Excellence (GR-Ex), Villejuif, France ; University Paris-Sud 11, Le Kremlin-Bicêtre, France ; Institut Gustave Roussy, Villejuif, France.

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0074257PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3774801PMC
May 2014

Concomitant germ-line RUNX1 and acquired ASXL1 mutations in a T-cell acute lymphoblastic leukemia.

Eur J Haematol 2013 Sep 28;91(3):277-9. Epub 2013 Jun 28.

Faculté de Médecine, Aix-Marseille Université, Marseille, France; Département d'Hématologie, Institut Paoli-Calmettes, Marseille, France.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/ejh.12147DOI Listing
September 2013

Small-molecule inhibitors in myeloproliferative neoplasms: are we aiming for the right targets?

Hematology Am Soc Hematol Educ Program 2012 ;2012:553-60

Ludwig Institute for Cancer Research, Brussels Branch, Brussels, Belgium.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1182/asheducation-2012.1.553DOI Listing
June 2013

[Megakaryopoiesis: regulation of platelet production by thrombopoietin].

Bull Acad Natl Med 2013 Feb;197(2):395-406

View Article

Download full-text PDF

Source
February 2013

MYH10 protein expression in platelets as a biomarker of RUNX1 and FLI1 alterations.

Blood 2012 Sep 7;120(13):2719-22. Epub 2012 Jun 7.

Institut National de la Santé et de la Recherche Médicale, Unité Mixte de Recherche (UMR) 1009, Villejuif, France.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1182/blood-2012-04-422352DOI Listing
September 2012

TET2, a tumor suppressor in hematological disorders.

Biochim Biophys Acta 2012 Apr 3;1825(2):173-7. Epub 2012 Jan 3.

INSERM, U985, Villejuif, France.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bbcan.2011.12.002DOI Listing
April 2012

[In cauda venenum or the importance of TET(2)].

Med Sci (Paris) 2011 Dec 23;27(12):1064-6. Epub 2011 Dec 23.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1051/medsci/20112712009DOI Listing
December 2011

New mutations and pathogenesis of myeloproliferative neoplasms.

Blood 2011 Aug 7;118(7):1723-35. Epub 2011 Jun 7.

Inserm, UMR1009, Institut Gustave Roussy, Villejuif, France.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1182/blood-2011-02-292102DOI Listing
August 2011

LYL-1 deficiency induces a stress erythropoiesis.

Exp Hematol 2011 Jun 21;39(6):629-42. Epub 2011 Mar 21.

INSERM U1009, IFR 54, Institut Gustave Roussy, Villejuif, France.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.exphem.2011.02.014DOI Listing
June 2011

Putative innate immunity of antiatherogenic paraoxanase-2 via STAT5 signal transduction in HIV-1 infection of hematopoietic TF-1 cells and in SCID-hu mice.

J Stem Cells 2010 ;5(1):43-8

Laboratory of Stem Cell Biology, Torrey Pines Institute for Molecular Studies, 3550 General Atomics Court, San Diego, California 92121, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/jsc.2010.5.1.43DOI Listing
April 2011

Myeloproliferative neoplasms: molecular pathophysiology, essential clinical understanding, and treatment strategies.

J Clin Oncol 2011 Feb 10;29(5):573-82. Epub 2011 Jan 10.

Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA.

View Article

Download full-text PDF

Source
http://ascopubs.org/doi/10.1200/JCO.2010.29.8711
Publisher Site
http://dx.doi.org/10.1200/JCO.2010.29.8711DOI Listing
February 2011