Publications by authors named "William Steinbach"

100Publications

Risks and outcomes of adenovirus disease in pediatric hematopoietic stem cell transplant recipients-Comparison of current antiviral treatment options.

Transpl Infect Dis 2020 Nov 10:e13505. Epub 2020 Nov 10.

Division of Infectious Diseases, Department of Pediatrics, Duke University School of Medicine, Durham, NC, USA.

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November 2020

Latest Thoughts on Treating Pediatric Mucormycosis.

J Pediatric Infect Dis Soc 2020 Nov;9(5):640-644

Division of Pediatric Infectious Diseases, Department of Pediatrics, Duke University Medical Center, Durham, North Carolina, USA.

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November 2020

Aspergillus fumigatus Cyp51A and Cyp51B Proteins Are Compensatory in Function and Localize Differentially in Response to Antifungals and Cell Wall Inhibitors.

Antimicrob Agents Chemother 2020 09 21;64(10). Epub 2020 Sep 21.

Department of Molecular Genetics and Microbiology, Duke University, Durham, North Carolina, USA

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September 2020

The class V myosin interactome of the human pathogen Aspergillus fumigatus reveals novel interactions with COPII vesicle transport proteins.

Biochem Biophys Res Commun 2020 06 1;527(1):232-237. Epub 2020 May 1.

Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC, 27710, USA; Department of Pediatrics, Duke University Medical Center, Durham, NC, 27710, USA. Electronic address:

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June 2020

FKBP12 dimerization mutations effect FK506 binding and differentially alter calcineurin inhibition in the human pathogen Aspergillus fumigatus.

Biochem Biophys Res Commun 2020 05 16;526(1):48-54. Epub 2020 Mar 16.

Division of Pediatric Infectious Diseases, Department of Pediatrics, Duke University Medical Center, Durham, NC, 27710, USA; Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC, 27710, USA. Electronic address:

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May 2020

Global guideline for the diagnosis and management of mucormycosis: an initiative of the European Confederation of Medical Mycology in cooperation with the Mycoses Study Group Education and Research Consortium.

Lancet Infect Dis 2019 12 5;19(12):e405-e421. Epub 2019 Nov 5.

Department of Medical Microbiology, Postgraduate Institute of Medical Education & Research, Chandigarh, India.

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December 2019

Funding Pediatric Subspecialty Training: Are T32 Grants the Future?

J Pediatr 2018 11;202:4-7.e1

Division of Pediatric Allergy and Immunology, Department of Pediatrics, Duke University, Durham, NC.

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November 2018

Kin1 kinase localizes at the hyphal septum and is dephosphorylated by calcineurin but is dispensable for septation and virulence in the human pathogen Aspergillus fumigatus.

Biochem Biophys Res Commun 2018 11 4;505(3):740-746. Epub 2018 Oct 4.

Division of Pediatric Infectious Diseases, Department of Pediatrics, Duke University Medical Center, Durham, USA. Electronic address:

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November 2018

Special Issue "Aspergillus fumigatus: From Diagnosis to Therapy".

J Fungi (Basel) 2016 Dec 8;2(4). Epub 2016 Dec 8.

Division of Pediatric Infectious Diseases, Department of Pediatrics, Duke University Medical Center, Durham, NC 27710, USA.

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December 2016

The tail domain of the class V myosin MyoE orchestrates septal localization and hyphal growth.

J Cell Sci 2018 02 7;131(3). Epub 2018 Feb 7.

Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC 27710, USA

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February 2018

Phosphorylation of Aspergillus fumigatus PkaR impacts growth and cell wall integrity through novel mechanisms.

FEBS Lett 2017 11 9;591(22):3730-3744. Epub 2017 Nov 9.

Division of Pediatric Infectious Diseases, Department of Pediatrics, Duke University Medical Center, Durham, NC, USA.

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November 2017

Recognition and Clinical Presentation of Invasive Fungal Disease in Neonates and Children.

J Pediatric Infect Dis Soc 2017 Sep;6(suppl_1):S12-S21

Aberdeen Fungal Group, Medical Research Council Centre for Medical Mycology, Institute of Medical Sciences, University of Aberdeen, and the Royal Aberdeen Children's Hospital, United Kingdom.

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September 2017

International Collaborative on Contemporary Epidemiology and Diagnosis of Invasive Fungal Disease in Children.

J Pediatric Infect Dis Soc 2017 Sep;6(suppl_1):S1-S2

Children's Hospital of Philadelphia, Pennsylvania.

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September 2017

Caspofungin-Mediated Growth Inhibition and Paradoxical Growth in Aspergillus fumigatus Involve Fungicidal Hyphal Tip Lysis Coupled with Regenerative Intrahyphal Growth and Dynamic Changes in β-1,3-Glucan Synthase Localization.

Antimicrob Agents Chemother 2017 10 22;61(10). Epub 2017 Sep 22.

Manchester Fungal Infection Group, Division of Infection, Immunity and Respiratory Medicine, University of Manchester, Manchester, United Kingdom

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October 2017

Risk Factors for Invasive Fungal Disease in Pediatric Cancer and Hematopoietic Stem Cell Transplantation: A Systematic Review.

J Pediatric Infect Dis Soc 2018 Aug;7(3):191-198

Division of Haematology/Oncology, Child Health Evaluative Sciences, Hospital for Sick Children, Toronto, Ontario, Canada.

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August 2018

Guideline for the Management of Fever and Neutropenia in Children With Cancer and Hematopoietic Stem-Cell Transplantation Recipients: 2017 Update.

J Clin Oncol 2017 Jun 1;35(18):2082-2094. Epub 2017 May 1.

Thomas Lehrnbecher, Hospital for Children and Adolescents, Johann Wolfgang Goethe University, Frankfurt; Andreas H. Groll, University Children's Hospital, Muenster, Germany; Paula Robinson, Pediatric Oncology Group of Ontario; Sarah Alexander, L. Lee Dupuis, and Lillian Sung, The Hospital for Sick Children, Toronto, Ontario, Canada; Brian Fisher and Theo Zaoutis, Children's Hospital of Philadelphia, Philadelphia, PA; Roland A. Ammann, Bern University Hospital, University of Bern, Switzerland; Melissa Beauchemin, Columbia University/Herbert Irving Cancer Center, New York, NY; Fabianne Carlesse, Pediatric Oncology Institute, GRAACC/Federal University of Sao Paulo, Sao Paulo, Brazil; Gabrielle M. Haeusler, Peter MacCallum Cancer Centre, Melbourne; Monash Children's Hospital, Clayton, Victoria, Australia; Maria Santolaya, Hospital Luis Calvo Mackenna, Universidad de Chile, Santiago, Chile; William J. Steinbach, Duke University Medical Center, Durham, NC; Elio Castagnola, Istituto Giannina Gaslini, Genova, Italy; Bonnie L. Davis, High Tor Limited, Nassau, Bahamas; Aditya H. Gaur, St Jude Children's Research Hospital, Memphis, TN; Wim J.E. Tissing, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands; and Robert Phillips, Leeds Teaching Hospital, NHS Trust, Leeds; University of York, York, United Kingdom.

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June 2017

Caspofungin exposure alters the core septin AspB interactome of Aspergillus fumigatus.

Biochem Biophys Res Commun 2017 04 24;485(2):221-226. Epub 2017 Feb 24.

Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC, United States; Division of Pediatric Infectious Diseases, Department of Pediatrics, Duke University Medical Center, Durham, NC, United States. Electronic address:

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April 2017

Forging the ring: from fungal septins' divergent roles in morphology, septation and virulence to factors contributing to their assembly into higher order structures.

Microbiology (Reading) 2016 09 23;162(9):1527-1534. Epub 2016 Aug 23.

Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC, USA.

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September 2016

Dephosphorylation of the Core Septin, AspB, in a Protein Phosphatase 2A-Dependent Manner Impacts Its Localization and Function in the Fungal Pathogen Aspergillus fumigatus.

Front Microbiol 2016 22;7:997. Epub 2016 Jun 22.

Department of Molecular Genetics and Microbiology, Duke University Medical Center, DurhamNC, USA; Division of Pediatric Infectious Diseases, Department of Pediatrics, Duke University Medical Center, DurhamNC, USA.

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July 2016

Calcineurin in fungal virulence and drug resistance: Prospects for harnessing targeted inhibition of calcineurin for an antifungal therapeutic approach.

Virulence 2017 02 20;8(2):186-197. Epub 2016 Jun 20.

a Department of Pediatrics , Division of Pediatric Infectious Diseases, Duke University School of Medicine , Durham , NC , USA.

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February 2017

Structures of Pathogenic Fungal FKBP12s Reveal Possible Self-Catalysis Function.

mBio 2016 Apr 26;7(2):e00492-16. Epub 2016 Apr 26.

Department of Biochemistry, Duke University School of Medicine, Durham, North Carolina, USA

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April 2016

Distinct Roles of Myosins in Aspergillus fumigatus Hyphal Growth and Pathogenesis.

Infect Immun 2016 05 22;84(5):1556-64. Epub 2016 Apr 22.

Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, North Carolina, USA Division of Pediatric Infectious Diseases, Department of Pediatrics, Duke University Medical Center, Durham, North Carolina, USA

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May 2016

Editorial: Advances in Aspergillus fumigatus Pathobiology.

Front Microbiol 2016 3;7:43. Epub 2016 Feb 3.

Division of Pediatric Infectious Diseases, Department of Pediatrics, Duke University Medical CenterDurham, NC, USA; Department of Molecular Genetics and Microbiology, Duke University Medical CenterDurham, NC, USA.

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February 2016

Novel motif in calcineurin catalytic subunit is required for septal localization of calcineurin in Aspergillus fumigatus.

FEBS Lett 2016 Feb 15;590(4):501-8. Epub 2016 Feb 15.

Division of Pediatric Infectious Diseases, Department of Pediatrics, Duke University Medical Center, Durham, NC, USA.

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February 2016

Pediatric Invasive Candidiasis: Epidemiology and Diagnosis in Children.

J Fungi (Basel) 2016 Jan 8;2(1). Epub 2016 Jan 8.

Department of Pediatrics, Duke University Medical Center, Durham, NC 27710, USA.

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January 2016

Calcineurin Orchestrates Hyphal Growth, Septation, Drug Resistance and Pathogenesis of Aspergillus fumigatus: Where Do We Go from Here?

Pathogens 2015 Dec 16;4(4):883-93. Epub 2015 Dec 16.

Department of Pediatrics, Division of Pediatric Infectious Diseases, Duke University Medical Center, Durham, NC 27710, USA.

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December 2015

A Prospective, International Cohort Study of Invasive Mold Infections in Children.

J Pediatric Infect Dis Soc 2015 Dec 16;4(4):313-22. Epub 2014 Jul 16.

Department of Pediatrics, Duke University, Durham, North Carolina Department of Molecular Genetics & Microbiology, Duke University, Durham, North Carolina.

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December 2015

Potential Microbiological Effects of Higher Dosing of Echinocandins.

Clin Infect Dis 2015 Dec;61 Suppl 6:S669-77

Division of Pediatric Infectious Diseases, Department of Pediatrics.

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December 2015

Characterization of the FKBP12-Encoding Genes in Aspergillus fumigatus.

PLoS One 2015 14;10(9):e0137869. Epub 2015 Sep 14.

Department of Pediatrics, Division of Pediatric Infectious Diseases, Duke University Medical Center, Durham, NC, United States of America; Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC, United States of America.

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June 2016

Blood-based Diagnosis of Invasive Fungal Infections in Immunocompromised/Oncology Patients.

Pediatr Infect Dis J 2015 Sep;34(9):1020-2

From the *Division of Pediatric Infectious Diseases, Department of Pediatrics, and †Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, North Carolina.

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September 2015

Calcium-Mediated Induction of Paradoxical Growth following Caspofungin Treatment Is Associated with Calcineurin Activation and Phosphorylation in Aspergillus fumigatus.

Antimicrob Agents Chemother 2015 Aug 8;59(8):4946-55. Epub 2015 Jun 8.

Division of Pediatric Infectious Diseases, Department of Pediatrics, Duke University Medical Center, Durham, North Carolina, USA Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, North Carolina, USA

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August 2015

The Aspergillus fumigatus septins play pleiotropic roles in septation, conidiation, and cell wall stress, but are dispensable for virulence.

Fungal Genet Biol 2015 Aug 5;81:41-51. Epub 2015 Jun 5.

Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC, United States; Division of Pediatric Infectious Diseases, Department of Pediatrics, Duke University Medical Center, Durham, NC, United States. Electronic address:

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August 2015

Hsp70 and the Cochaperone StiA (Hop) Orchestrate Hsp90-Mediated Caspofungin Tolerance in Aspergillus fumigatus.

Antimicrob Agents Chemother 2015 Aug 26;59(8):4727-33. Epub 2015 May 26.

Division of Pediatric Infectious Diseases, Department of Pediatrics, Duke University Medical Center, Durham, North Carolina, USA Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, North Carolina, USA.

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August 2015

Identification and mutational analyses of phosphorylation sites of the calcineurin-binding protein CbpA and the identification of domains required for calcineurin binding in Aspergillus fumigatus.

Front Microbiol 2015 13;6:175. Epub 2015 Mar 13.

Division of Pediatric Infectious Diseases, Department of Pediatrics, Duke University Medical Center Durham, NC, USA ; Department of Molecular Genetics and Microbiology, Duke University Medical Center Durham, NC, USA.

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March 2015

Histone deacetylase inhibition as an alternative strategy against invasive aspergillosis.

Front Microbiol 2015 16;6:96. Epub 2015 Feb 16.

Division of Pediatric Infectious Diseases, Department of Pediatrics, Duke University Medical Center , Durham, NC, USA ; Department of Molecular Genetics and Microbiology, Duke University Medical Center , Durham, NC, USA.

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March 2015

Bronchoalveolar lavage and lung biopsy in patients with cancer and hematopoietic stem-cell transplantation recipients: a systematic review and meta-analysis.

J Clin Oncol 2015 Feb 5;33(5):501-9. Epub 2015 Jan 5.

DeepakBabu Chellapandian, Joseph Beyene, and Lillian Sung, The Hospital for Sick Children, Toronto; Joseph Beyene, McMaster University, Hamilton, Ontario, Canada; Thomas Lehrnbecher, Johann Wolfgang Goethe University, Frankfurt, Germany; Bob Phillips, Centre for Reviews and Dissemination, University of York, York, United Kingdom; Brian T. Fisher and Theoklis E. Zaoutis, Children's Hospital of Philadelphia, Philadelphia, PA; and William J. Steinbach, Duke University Medical Center, Durham, NC.

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February 2015

Antifungal activity of compounds targeting the Hsp90-calcineurin pathway against various mould species.

J Antimicrob Chemother 2015 May 3;70(5):1408-11. Epub 2015 Jan 3.

Division of Pediatric Infectious Diseases, Department of Pediatrics, Duke University Medical Center, Durham, NC, USA Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC, USA.

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May 2015

Calcineurin as a Multifunctional Regulator: Unraveling Novel Functions in Fungal Stress Responses, Hyphal Growth, Drug Resistance, and Pathogenesis.

Fungal Biol Rev 2014 Oct;28(2-3):56-69

Department of Pediatrics, Division of Pediatric Infectious Diseases, Duke University Medical Center, Durham NC, USA ; Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham NC, USA.

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October 2014

Aspergillus fumigatus and related species.

Cold Spring Harb Perspect Med 2014 Nov 6;5(2):a019786. Epub 2014 Nov 6.

Department of Pediatrics, Division of Pediatric Infectious Diseases, Duke University, Durham, North Carolina 27715 Department of Molecular Genetics and Microbiology, Duke University, Durham, North Carolina 27710.

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November 2014

Heat shock protein 90 (Hsp90): A novel antifungal target against Aspergillus fumigatus.

Crit Rev Microbiol 2016 22;42(2):310-21. Epub 2014 Sep 22.

a Division of Pediatric Infectious Diseases, Department of Pediatrics , Duke University Medical Center , Durham , NC , USA .

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December 2016

Calcineurin-mediated regulation of hyphal growth, septation, and virulence in Aspergillus fumigatus.

Mycopathologia 2014 Dec 15;178(5-6):341-8. Epub 2014 Aug 15.

Division of Pediatric Infectious Diseases, Department of Pediatrics, Duke University Medical Center, 427 Jones Building, Research Drive, Durham, NC, 27710, USA,

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December 2014

Candida speciation, antifungal treatment and adverse events in pediatric invasive candidiasis: results from 441 infections in a prospective, multi-national study.

Pediatr Infect Dis J 2014 Dec;33(12):1294-6

From the *Baylor College of Medicine and Texas Children's Hospital, Houston, TX; †Children's Hospital of Orange County, Orange, CA; ‡Istituto Giannina Gaslini, Genova, Italy; §Monroe Carell Jr. Children's Hospital at Vanderbilt University, Nashville, TN; ¶Children's Hospital of Philadelphia, Philadelphia, PA; and ‖Duke University, Durham, NC.

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December 2014

Identification of a key lysine residue in heat shock protein 90 required for azole and echinocandin resistance in Aspergillus fumigatus.

Antimicrob Agents Chemother 2014 6;58(4):1889-96. Epub 2014 Jan 6.

Division of Pediatric Infectious Diseases, Department of Pediatrics, Duke University Medical Center, Durham, North Carolina, USA.

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November 2014

Are we there yet? Recent progress in the molecular diagnosis and novel antifungal targeting of Aspergillus fumigatus and invasive aspergillosis.

PLoS Pathog 2013 Oct 24;9(10):e1003642. Epub 2013 Oct 24.

Department of Pediatrics, Division of Pediatric Infectious Diseases, Duke University Medical Center, Durham, North Carolina, United States of America ; Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, North Carolina, United States of America.

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October 2013

Phosphorylation of Calcineurin at a novel serine-proline rich region orchestrates hyphal growth and virulence in Aspergillus fumigatus.

PLoS Pathog 2013 22;9(8):e1003564. Epub 2013 Aug 22.

Department of Pediatrics, Division of Pediatric Infectious Diseases, Duke University Medical Center, Durham, North Carolina, United States of America.

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March 2014

Filamentous fungal-specific septin AspE is phosphorylated in vivo and interacts with actin, tubulin and other septins in the human pathogen Aspergillus fumigatus.

Biochem Biophys Res Commun 2013 Feb 12;431(3):547-53. Epub 2013 Jan 12.

Division of Pediatric Infectious Diseases, Department of Pediatrics, Duke University Medical Center, Durham, NC 27710, USA.

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February 2013

In vitro activity of calcineurin and heat shock protein 90 Inhibitors against Aspergillus fumigatus azole- and echinocandin-resistant strains.

Antimicrob Agents Chemother 2013 Feb 19;57(2):1035-9. Epub 2012 Nov 19.

Division of Pediatric Infectious Diseases, Department of Pediatrics, Duke University Medical Center, Durham, North Carolina, USA.

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February 2013

Clinical epidemiology of 960 patients with invasive aspergillosis from the PATH Alliance registry.

J Infect 2012 Nov 13;65(5):453-64. Epub 2012 Aug 13.

Division of Pediatric Infectious Diseases, Department of Pediatrics, Duke University Medical Center, Durham, NC 27710, USA.

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November 2012

Heat shock protein 90 is required for conidiation and cell wall integrity in Aspergillus fumigatus.

Eukaryot Cell 2012 Nov 20;11(11):1324-32. Epub 2012 Jul 20.

Division of Pediatric Infectious Diseases, Department of Pediatrics, Duke University Medical Center, Durham, NC, USA.

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November 2012

Antifungal prophylaxis in pediatric hematology/oncology: new choices & new data.

Pediatr Blood Cancer 2012 Jul 18;59(1):21-6. Epub 2011 Nov 18.

Division of Pediatric Blood & Marrow Transplant, Department of Pediatrics, University of California San Francisco, San Francisco, California 94143-1278, USA.

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July 2012

Polyhexamethylene biguanide and calcineurin inhibitors as novel antifungal treatments for Aspergillus keratitis.

Invest Ophthalmol Vis Sci 2011 Sep 21;52(10):7309-15. Epub 2011 Sep 21.

Duke University Eye Center, Duke University Medical Center, Durham, North Carolina 27710, USA.

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September 2011

The chitin synthase genes chsA and chsC are not required for cell wall stress responses in the human pathogen Aspergillus fumigatus.

Biochem Biophys Res Commun 2011 Aug 5;411(3):549-54. Epub 2011 Jul 5.

Department of Pediatrics, Division of Pediatric Infectious Diseases, Duke University Medical Center, Durham, NC 27710, USA.

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August 2011

Regulation of expression, activity and localization of fungal chitin synthases.

Med Mycol 2012 Jan 28;50(1):2-17. Epub 2011 Apr 28.

Department of Pediatrics, Division of Pediatric Infectious Diseases, Duke University Medical Center, Durham, NC 27710, USA.

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January 2012

Regulatable Ras activity is critical for proper establishment and maintenance of polarity in Aspergillus fumigatus.

Eukaryot Cell 2011 Apr 28;10(4):611-5. Epub 2011 Jan 28.

Department of Pediatrics, Duke University Medical Center, Durham, NC 27710, USA.

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April 2011

Differential localization patterns of septins during growth of the human fungal pathogen Aspergillus fumigatus reveal novel functions.

Biochem Biophys Res Commun 2011 Feb 8;405(2):238-43. Epub 2011 Jan 8.

Division of Pediatric Infectious Diseases, Department of Pediatrics, Duke University Medical Center, Durham, NC 27710, USA.

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February 2011

Rational approach to pediatric antifungal therapy.

Adv Exp Med Biol 2011 ;697:231-42

Department of Pediatrics, Division of Pediatric Infectious Diseases, Duke University, Durham, USA.

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February 2011

Pediatric invasive aspergillosis.

Pediatr Infect Dis J 2010 Oct;29(10):964-5

Department of Pediatrics, Duke University, Durham, NC, USA.

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October 2010

Newer combination antifungal therapies for invasive aspergillosis.

Med Mycol 2011 Apr 7;49 Suppl 1:S77-81. Epub 2010 Jul 7.

Department of Pediatrics, Division of Pediatric Infectious Diseases, Duke University, Durham, NC 27710, USA.

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April 2011

Invasive aspergillosis in pediatric patients.

Curr Med Res Opin 2010 Jul;26(7):1779-87

Division of Pediatric Infectious Diseases, Duke University Medical Center, Durham, NC 27710, USA.

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July 2010

Surfactant protein D binding to Aspergillus fumigatus hyphae is calcineurin-sensitive.

Med Mycol 2010 Jun;48(4):580-8

Department of Cell Biology, Duke University Medical Center, Durham, North Carolina 27710, USA.

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June 2010

Transcriptional regulation of chitin synthases by calcineurin controls paradoxical growth of Aspergillus fumigatus in response to caspofungin.

Antimicrob Agents Chemother 2010 Apr 1;54(4):1555-63. Epub 2010 Feb 1.

Departments of Pediatrics, Duke University Medical Center, Durham, North Carolina 27710, USA.

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April 2010

Stress, drugs, and evolution: the role of cellular signaling in fungal drug resistance.

Eukaryot Cell 2008 May 28;7(5):747-64. Epub 2008 Mar 28.

University of Toronto, Department of Molecular Genetics, Medical Sciences Bldg., Rm. 4368, 1 King's College Circle, Toronto M5S 1A8, Canada.

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May 2008