William Slikker

William Slikker

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William Slikker

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Effects of Xenon-Based Anesthetic Exposure on the Expression Levels of Polysialic Acid Neural Cell Adhesion Molecule (PSA-NCAM) on Human Neural Stem Cell-Derived Neurons.

Mol Neurobiol 2020 Jan 15;57(1):217-225. Epub 2019 Sep 15.

Division of Neurotoxicology, National Center for Toxicological Research/FDA, Jefferson, AR, USA.

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http://dx.doi.org/10.1007/s12035-019-01771-xDOI Listing
January 2020

Protective Effects of Xenon on Propofol-Induced Neurotoxicity in Human Neural Stem Cell-Derived Models.

Mol Neurobiol 2020 Jan;57(1):200-207

Office of Director, National Center for Toxicological Research/FDA, Jefferson, AR, USA.

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http://dx.doi.org/10.1007/s12035-019-01769-5DOI Listing
January 2020

Saline Load Test for Detecting Traumatic Arthrotomy in the Wrist.

J Wrist Surg 2019 Jun 8;8(3):221-225. Epub 2019 Mar 8.

Department of Orthopedic Surgery, Rush University Medical Center, Chicago, Illinois.

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http://dx.doi.org/10.1055/s-0039-1683365DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6546484PMC
June 2019

Thoughts From a Research Career by William Slikker Jr, the ATS 2019 Mildred S. Christian Career Achievement Award Winner.

Authors:
William Slikker

Int J Toxicol 2019 Sep/Oct;38(5):336-338. Epub 2019 May 23.

NCTR, Jefferson, AR, USA.

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http://dx.doi.org/10.1177/1091581819851780DOI Listing
May 2019

A randomized controlled laboratory study on the long-term effects of methylphenidate on cardiovascular function and structure in rhesus monkeys.

Pediatr Res 2019 02 17;85(3):398-404. Epub 2018 Dec 17.

Department of Pediatrics, University at Buffalo Jacobs School of Medicine and Biomedical Sciences, Oishei Children's Hospital, Roswell Park Comprehensive Cancer Center, Buffalo, NY, 14203, USA.

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http://dx.doi.org/10.1038/s41390-018-0256-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6779032PMC
February 2019

Lipidomics reveals a systemic energy deficient state that precedes neurotoxicity in neonatal monkeys after sevoflurane exposure.

Anal Chim Acta 2018 Dec 30;1037:87-96. Epub 2017 Nov 30.

Barshop Institute for Longevity and Aging Studies, University of Texas Health Science Center at San Antonio, TX 78229, USA; Department of Medicine, Division of Diabetes, University of Texas Health Science Center at San Antonio, TX 78229, USA; Department of Biochemistry and Structural Biology, University of Texas Health Science Center at San Antonio, TX 78229, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00032670173133
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http://dx.doi.org/10.1016/j.aca.2017.11.052DOI Listing
December 2018

Electron microscopy techniques employed to explore mitochondrial defects in the developing rat brain following ketamine treatment.

Exp Cell Res 2018 12 18;373(1-2):164-170. Epub 2018 Oct 18.

NCTR/ORA Nanotechnology Core Facility, Office of Scientific Coordination, National Center for Toxicological Research, US Food and Drug Administration, 3900 NCTR Road, Jefferson, AR 72079, United States. Electronic address:

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http://dx.doi.org/10.1016/j.yexcr.2018.10.009DOI Listing
December 2018

Lipid profiling as an effective approach for identifying biomarkers/adverse events associated with pediatric anesthesia.

Toxicol Appl Pharmacol 2018 09 15;354:191-195. Epub 2018 Mar 15.

National Center for Toxicological Research/Food and Drug Administration, Jefferson, AR 72079, USA.

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http://dx.doi.org/10.1016/j.taap.2018.03.017DOI Listing
September 2018

Lipidomics Reveals Changes in Metabolism, Indicative of Anesthetic-Induced Neurotoxicity in Developing Brains.

Chem Res Toxicol 2018 09 4;31(9):825-835. Epub 2018 Sep 4.

Department of Anesthesiology , Central Arkansas Veterans Health System , 4300 West Seventh Street, VA 704-110 , Little Rock , Arkansas 72205 , United States.

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http://dx.doi.org/10.1021/acs.chemrestox.8b00186DOI Listing
September 2018

Characterization of uniaxial high-speed stretch as an in vitro model of mild traumatic brain injury on the blood-brain barrier.

Neurosci Lett 2018 04 16;672:123-129. Epub 2018 Feb 16.

Division of Neurotoxicology, National Center for Toxicological Research, 3900 NCTR Road, Jefferson, AR, 72079, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S03043940183009
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http://dx.doi.org/10.1016/j.neulet.2018.02.019DOI Listing
April 2018

Biomarkers and their impact on precision medicine.

Authors:
William Slikker

Exp Biol Med (Maywood) 2018 02 19;243(3):211-212. Epub 2017 Sep 19.

National Center for Toxicological Research, US-Food and Drug Administration, Jefferson, AR 72079, USA.

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http://dx.doi.org/10.1177/1535370217733426DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5813864PMC
February 2018

Characterization of Biaxial Stretch as an In Vitro Model of Traumatic Brain Injury to the Blood-Brain Barrier.

Mol Neurobiol 2018 01;55(1):258-266

Neurochemistry Laboratory, Division of Neurotoxicology, National Center for Toxicological Research/FDA, Jefferson, AR, 72079, USA.

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http://dx.doi.org/10.1007/s12035-017-0738-5DOI Listing
January 2018

Commentary.

Authors:
William Slikker

Exp Biol Med (Maywood) 2017 06;242(12):1213

Associate Editor.

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http://dx.doi.org/10.1177/1535370217714404DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5476345PMC
June 2017

Relationship between ketamine-induced developmental neurotoxicity and NMDA receptor-mediated calcium influx in neural stem cell-derived neurons.

Neurotoxicology 2017 May 27;60:254-259. Epub 2016 Apr 27.

Office of the Director, National Center for Toxicological Research/Food and Drug Administration, Jefferson, AR 72079, USA.

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http://dx.doi.org/10.1016/j.neuro.2016.04.015DOI Listing
May 2017

Regulatory bioinformatics for food and drug safety.

Regul Toxicol Pharmacol 2016 Oct 18;80:342-7. Epub 2016 May 18.

National Center for Toxicological Research, US Food and Drug Administration, Jefferson, AR, 72079-9502, USA. Electronic address:

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http://dx.doi.org/10.1016/j.yrtph.2016.05.021DOI Listing
October 2016

Potential Reuse of Oncology Drugs in the Treatment of Rare Diseases.

Trends Pharmacol Sci 2016 10 22;37(10):843-857. Epub 2016 Jul 22.

National Center for Toxicological Research, US Food and Drug Administration, Jefferson, AR 72079, USA. Electronic address:

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http://dx.doi.org/10.1016/j.tips.2016.06.010DOI Listing
October 2016

Advancing translation of biomarkers into regulatory science.

Biomark Med 2015 ;9(11):1043-6

Office of the Director, National Center for Toxicological Research, US Food & Drug Administration, 3900 NCTR Road, Jefferson, AR 72079, USA.

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http://dx.doi.org/10.2217/bmm.15.104DOI Listing
August 2016

In Vivo Monitoring of Sevoflurane-induced Adverse Effects in Neonatal Nonhuman Primates Using Small-animal Positron Emission Tomography.

Anesthesiology 2016 07;125(1):133-46

From the Divisions of Neurotoxicology (X.Z., S.L., G.D.N., M.G.P., F.L., T.A.P., C.W.) and Bioinformatics and Biostatistics (M.P.M.) and Priority One Services (R.C., J.T.), National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, Arkansas; 3D Imaging, LLC, Little Rock, Arkansas (M.S.B., S.M.A., C.C.B.); and Center for Drug Evaluation and Research/U.S. Food and Drug Administration, Silver Spring, Maryland (J.P.H., W.S.).

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http://dx.doi.org/10.1097/ALN.0000000000001154DOI Listing
July 2016

Quantification and correlation of hip capsular volume to demographic and radiographic predictors.

Knee Surg Sports Traumatol Arthrosc 2016 Jun 14;24(6):2009-15. Epub 2014 Sep 14.

Division of Sports Medicine, Department of Orthopedic Surgery, Hip Preservation Center, Rush University Medical Center, Rush Medical College of Rush University, 1611 W. Harrison St, Suite 300, Chicago, IL, 60612, USA.

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http://dx.doi.org/10.1007/s00167-014-3275-zDOI Listing
June 2016

Comparing Morbidities of Bone Graft Harvesting from the Olecranon Process and the Distal Radius.

Plast Reconstr Surg Glob Open 2016 Feb 19;4(2):e623. Epub 2016 Feb 19.

Department of Orthopaedic Surgery, Northwestern University Feinberg School of Medicine, Chicago, Ill.; Midwest Orthopaedics, Rush University Medical Center, Chicago, Ill.; Department of Preventative Medicine, Northwestern University Feinberg School of Medicine, Chicago, Ill.; and Orthopaedic Specialty Group, Fairfield, Conn.

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http://dx.doi.org/10.1097/GOX.0000000000000617DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4778894PMC
February 2016

Clinical Outcomes of the Flexor Carpi Ulnaris Turnover Flap for Posterior Elbow Soft Tissue Defects.

J Hand Surg Am 2015 Dec;40(12):2358-63

Section of Hand and Elbow Surgery, Department of Orthopaedic Surgery, Rush University Medical Center, Chicago, IL. Electronic address:

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http://dx.doi.org/10.1016/j.jhsa.2015.09.004DOI Listing
December 2015

Ketamine-Induced Toxicity in Neurons Differentiated from Neural Stem Cells.

Mol Neurobiol 2015 Oct 9;52(2):959-69. Epub 2015 Jun 9.

Office of the Director, National Center for Toxicological Research/Food and Drug Administration, Jefferson, AR, 72079, USA,

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http://dx.doi.org/10.1007/s12035-015-9248-5DOI Listing
October 2015

Potential Adverse Effects of Prolonged Sevoflurane Exposure on Developing Monkey Brain: From Abnormal Lipid Metabolism to Neuronal Damage.

Toxicol Sci 2015 Oct 23;147(2):562-72. Epub 2015 Jul 23.

Diabetes and Obesity Research Center, Sanford-Burnham Medical Research Institute at Lake Nona, Orlando, FL 32827; and.

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http://dx.doi.org/10.1093/toxsci/kfv150DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4707202PMC
October 2015

Arthroscopic-Assisted Outside-In Repair of Triangular Fibrocartilage Complex Tears.

Arthrosc Tech 2015 Oct 21;4(5):e577-81. Epub 2015 Oct 21.

Department of Orthopaedic Surgery, Rush University Medical Center, Chicago, Illinois, U.S.A.

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http://dx.doi.org/10.1016/j.eats.2015.06.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4722249PMC
October 2015

Total Wrist Fusion Using an Intramedullary Rod Technique With Proximal Row Carpectomy.

Tech Hand Up Extrem Surg 2015 Sep;19(3):133-6

Department of Orthopaedic Surgery, Rush University Medical Center, Chicago, IL.

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http://dx.doi.org/10.1097/BTH.0000000000000093DOI Listing
September 2015

Prevalence of Femoroacetabular Impingement Imaging Findings in Asymptomatic Volunteers: A Systematic Review.

Arthroscopy 2015 Jun 28;31(6):1199-204. Epub 2015 Jan 28.

Hip Preservation Center, Division of Sports Medicine, Department of Orthopedic Surgery, Rush University Medical Center, Rush Medical College of Rush University, Chicago, Illinois, U.S.A.

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http://www.ishameetings.net/assets/isha/2014_ePosters/1004_H
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http://imr.sagepub.com/content/39/3/790.full.pdf
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http://linkinghub.elsevier.com/retrieve/pii/S074980631400968
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http://dx.doi.org/10.1016/j.arthro.2014.11.042DOI Listing
June 2015

Genomics in the land of regulatory science.

Regul Toxicol Pharmacol 2015 Jun 18;72(1):102-6. Epub 2015 Mar 18.

National Center for Toxicological Research, US Food and Drug Administration, Jefferson, AR, USA. Electronic address:

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http://dx.doi.org/10.1016/j.yrtph.2015.03.008DOI Listing
June 2015

Effects of silver nanoparticles on human and rat embryonic neural stem cells.

Front Neurosci 2015 8;9:115. Epub 2015 Apr 8.

Division of Neurotoxicology, National Center for Toxicological Research/Food and Drug Administration Jefferson, AR, USA.

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http://dx.doi.org/10.3389/fnins.2015.00115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4389354PMC
April 2015

Global Summit on Regulatory Science 2013.

Regul Toxicol Pharmacol 2014 Dec 13;70(3):728-32. Epub 2014 Aug 13.

National Center for Toxicological Research, U.S. Food & Drug Administration, Jefferson, AR, USA.

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http://dx.doi.org/10.1016/j.yrtph.2014.08.004DOI Listing
December 2014

The use of MRI to assist the section selections for classical pathology assessment of neurotoxicity.

Regul Toxicol Pharmacol 2014 Dec 28;70(3):641-7. Epub 2014 Sep 28.

Division of Neurotoxicology, National Center for Toxicological Research, Jefferson, AR 72079, United States.

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http://dx.doi.org/10.1016/j.yrtph.2014.09.010DOI Listing
December 2014

Positron Emission Tomography with [(18)F]FLT Revealed Sevoflurane-Induced Inhibition of Neural Progenitor Cell Expansion in vivo.

Front Neurol 2014 17;5:234. Epub 2014 Nov 17.

Division of Neurotoxicology, National Center for Toxicological Research, U.S. Food and Drug Administration , Jefferson, AR , USA.

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http://dx.doi.org/10.3389/fneur.2014.00234DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4233913PMC
December 2014

Of human-on-a-chip and humans: considerations for creating and using microphysiological systems.

Authors:
William Slikker

Exp Biol Med (Maywood) 2014 Sep 8;239(9):1078-9. Epub 2014 Jul 8.

National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR 72079, USA

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http://dx.doi.org/10.1177/1535370214537754DOI Listing
September 2014

Protective effect of acetyl-L-carnitine on propofol-induced toxicity in embryonic neural stem cells.

Neurotoxicology 2014 May 2;42:49-57. Epub 2014 Apr 2.

Division of Neurotoxicology, National Center for Toxicological Research/Food and Drug Administration, Jefferson, AR 72079, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neuro.2014.03.011DOI Listing
May 2014

Evidence of capsular defect following hip arthroscopy.

Knee Surg Sports Traumatol Arthrosc 2014 Apr 13;22(4):902-5. Epub 2013 Jul 13.

Hip Preservation Center, Division of Sports Medicine, Department of Orthopaedic Surgery, Rush University Medical Center, Rush Medical College, Rush University, Chicago, IL, USA,

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http://dx.doi.org/10.1007/s00167-013-2591-zDOI Listing
April 2014

Reverse total shoulder arthroplasty for acute proximal humeral fracture: comparison to open reduction-internal fixation and hemiarthroplasty.

J Shoulder Elbow Surg 2014 Feb 27;23(2):197-204. Epub 2013 Sep 27.

Department of Orthopaedic Surgery, Rush University Medical Center, Chicago, IL, USA.

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http://dx.doi.org/10.1016/j.jse.2013.07.044DOI Listing
February 2014

Utilization of neural stem cell-derived models to study anesthesia-related toxicity and preventative approaches.

Mol Neurobiol 2013 Oct 12;48(2):302-7. Epub 2013 Jul 12.

Division of Neurotoxicology, National Center for Toxicological Research (NCTR)/FDA, Jefferson, AR, USA,

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http://dx.doi.org/10.1007/s12035-013-8501-zDOI Listing
October 2013

Pathways of neurotoxicity and innovative neuroprotective strategies. Preface.

Mol Neurobiol 2013 Oct 26;48(2):271-3. Epub 2013 Jul 26.

National Center for Toxicological Research, Food and Drug Administration, 3900 NCTR Rd., Jefferson, AR, 72079, USA.

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http://dx.doi.org/10.1007/s12035-013-8513-8DOI Listing
October 2013

Application of microPET imaging approaches in the study of pediatric anesthetic-induced neuronal toxicity.

J Appl Toxicol 2013 Sep 11;33(9):861-8. Epub 2013 Feb 11.

Division of Neurotoxicology, National Center for Toxicological Research (NCTR)/FDA, Jefferson, AR 72079, USA.

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http://doi.wiley.com/10.1002/jat.2857
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http://dx.doi.org/10.1002/jat.2857DOI Listing
September 2013

Preclinical assessment of ketamine.

CNS Neurosci Ther 2013 Jun 6;19(6):448-53. Epub 2013 Mar 6.

Division of Neurotoxicology, National Center for Toxicological Research (NCTR)/FDA, Jefferson, AR 72079-9501, USA.

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http://dx.doi.org/10.1111/cns.12079DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6493590PMC
June 2013

Routine complete capsular closure during hip arthroscopy.

Arthrosc Tech 2013 May 17;2(2):e89-94. Epub 2013 Mar 17.

Hip Preservation Center, Division of Sports Medicine, Department of Orthopaedic Surgery, Rush University Medical Center, Rush Medical College, Rush University, Chicago, Illinois, U.S.A.

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http://dx.doi.org/10.1016/j.eats.2012.11.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3716194PMC
May 2013

In silico drug repositioning: what we need to know.

Drug Discov Today 2013 Feb 28;18(3-4):110-5. Epub 2012 Aug 28.

ICF International at FDA National Center for Toxicological Research, Jefferson, AR 72079, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S13596446120029
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http://dx.doi.org/10.1016/j.drudis.2012.08.005DOI Listing
February 2013

Ketamine-induced neuronal damage and altered N-methyl-D-aspartate receptor function in rat primary forebrain culture.

Toxicol Sci 2013 Feb 11;131(2):548-57. Epub 2012 Oct 11.

Division of Neurotoxicology, National Center for Toxicological Research, Food and Drug Administration, 3900 NCTR Rd., Jefferson, AR 72079-0502, USA.

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http://dx.doi.org/10.1093/toxsci/kfs296DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3551423PMC
February 2013

2012 Global Summit on Regulatory Science (GSRS-2012)--modernizing toxicology.

Toxicol Sci 2013 Jan 24;131(1):9-12. Epub 2012 Aug 24.

National Center for Toxicological Research, US Food and Drug Administration, Jefferson, Arkansas 72079, USA.

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https://academic.oup.com/toxsci/article/1625283/2012
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http://dx.doi.org/10.1093/toxsci/kfs254DOI Listing
January 2013

Inhalation Anesthesia-Induced Neuronal Damage and Gene Expression Changes in Developing Rat Brain.

Syst Pharmacol 2013 1;1:1-9. Epub 2013 Jan 1.

Division of Neurotoxicology, National Center for Toxicological Research, U.S. Food & Drug Administration, 3900 NCTR Rd., Jefferson, AR 72079 USA.

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http://dx.doi.org/10.2478/sph-2012-0001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5755976PMC
January 2013

The use of double-loaded suture anchors for labral repair and capsular repair during hip arthroscopy.

Arthrosc Tech 2012 Dec 2;1(2):e213-7. Epub 2012 Nov 2.

Healthy Hip Clinic, Division of Sports Medicine, Department of Orthopedic Surgery, Rush University Medical Center, Rush Medical College, Chicago, Illinois, U.S.A.

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http://dx.doi.org/10.1016/j.eats.2012.08.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3678646PMC
December 2012

Effects of copper nanoparticles on rat cerebral microvessel endothelial cells.

Nanomedicine (Lond) 2012 Jun 16;7(6):835-46. Epub 2012 Feb 16.

Neurochemistry Laboratory, Division of Neurotoxicology, National Center for Toxicological Research/FDA, Jefferson, AR 72079, USA.

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http://dx.doi.org/10.2217/nnm.11.154DOI Listing
June 2012

What it means to be global.

Toxicol Sci 2012 May 14;127(1):313-4. Epub 2012 Feb 14.

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http://dx.doi.org/10.1093/toxsci/kfs079DOI Listing
May 2012

Advancing global health through regulatory science research: summary of the Global Summit on Regulatory Science Research and Innovation.

Regul Toxicol Pharmacol 2012 Apr 7;62(3):471-3. Epub 2012 Feb 7.

United States Food and Drug Administration, Silver Spring, MD 20993, USA.

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http://dx.doi.org/10.1016/j.yrtph.2012.02.001DOI Listing
April 2012

Osteochondral lesions of the talus: effect of defect size and plantarflexion angle on ankle joint stresses.

Am J Sports Med 2012 Apr 23;40(4):895-901. Epub 2012 Feb 23.

Department of Orthopaedic Surgery, Stanford University, Stanford, California, USA.

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http://dx.doi.org/10.1177/0363546511434404DOI Listing
April 2012

Inhalation anesthetic-induced neuronal damage in the developing rhesus monkey.

Neurotoxicol Teratol 2011 Sep-Oct;33(5):592-7. Epub 2011 Jun 25.

Division of Neurotoxicology, National Center for Toxicological Research/U.S. Food and Drug Administration, Jefferson, AR 72079, USA.

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http://dx.doi.org/10.1016/j.ntt.2011.06.003DOI Listing
January 2012

Brain microvessel endothelial cells responses to gold nanoparticles: In vitro pro-inflammatory mediators and permeability.

Nanotoxicology 2011 Dec 22;5(4):479-92. Epub 2010 Dec 22.

Neurochemistry Laboratory, Division of Neurotoxicology, National Center of Toxicological Research/FDA, Jefferson, Arkansas, USA.

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http://dx.doi.org/10.3109/17435390.2010.540356DOI Listing
December 2011

Mechanistic toxicity evaluation of uncoated and PEGylated single-walled carbon nanotubes in neuronal PC12 cells.

ACS Nano 2011 Sep 7;5(9):7020-33. Epub 2011 Sep 7.

National Center for Toxicological Research, Food and Drug Administration, 3900 NCTR Road, Jefferson, Arkansas 72079, USA.

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http://dx.doi.org/10.1021/nn2016259DOI Listing
September 2011

Pubertal delay in male nonhuman primates (Macaca mulatta) treated with methylphenidate.

Proc Natl Acad Sci U S A 2011 Sep 19;108(39):16301-6. Epub 2011 Sep 19.

Epidemiology Branch, Division of Epidemiology, Statistics, and Prevention Research, The Eunice Kennedy Shriver National Institute for Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1073/pnas.1102187108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3182701PMC
September 2011

Human neural stem cells enhance structural plasticity and axonal transport in the ischaemic brain.

Brain 2011 Jun;134(Pt 6):1777-89

Department of Neurosurgery, Stanford Stroke Centre, Stanford Institute for Neuro-Innovation and Translational Neurosciences, Stanford University School of Medicine, 1201 Welch Road, Stanford, CA 94305-5487, USA.

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http://dx.doi.org/10.1093/brain/awr094DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3102243PMC
June 2011

Silver nanoparticle induced blood-brain barrier inflammation and increased permeability in primary rat brain microvessel endothelial cells.

Toxicol Sci 2010 Nov 16;118(1):160-70. Epub 2010 Aug 16.

Neurochemistry Laboratory, Division of Neurotoxicology, National Center of Toxicological Research/Food and Drug Administration, Jefferson, Arkansas 72079, USA.

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http://dx.doi.org/10.1093/toxsci/kfq244DOI Listing
November 2010

Anesthetic-induced oxidative stress and potential protection.

ScientificWorldJournal 2010 Jul 20;10:1473-82. Epub 2010 Jul 20.

National Center for Toxicological Research, U.S. Food & Drug Administration, Jefferson, AR, USA.

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http://dx.doi.org/10.1100/tsw.2010.118DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5763762PMC
July 2010

Evaluation of mutagenic mode of action in Big Blue mice fed methylphenidate for 24 weeks.

Mutat Res 2009 Nov-Dec;680(1-2):43-8. Epub 2009 Sep 22.

Division of Genetic and Reproductive Toxicology, National Center for Toxicological Research (NCTR), US Food and Drug Administration, Jefferson, AR 72079, United States.

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http://dx.doi.org/10.1016/j.mrgentox.2009.09.004DOI Listing
April 2010

Approaches for assessing risks to sensitive populations: lessons learned from evaluating risks in the pediatric population.

Toxicol Sci 2010 Jan 21;113(1):4-26. Epub 2009 Sep 21.

Medical College of Wisconsin, Department of Pediatrics, Children's Research Institute, Children's Hospital and Health Systems, Milwaukee, Wisconsin 53226-4801, USA.

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http://dx.doi.org/10.1093/toxsci/kfp217DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3469276PMC
January 2010

Prolonged exposure to ketamine increases neurodegeneration in the developing monkey brain.

Int J Dev Neurosci 2009 Nov 4;27(7):727-31. Epub 2009 Jul 4.

Division of Neurotoxicology, National Center for Toxicological Research, US Food and Drug Administration, Jefferson, AR 72079, USA.

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http://dx.doi.org/10.1016/j.ijdevneu.2009.06.010DOI Listing
November 2009

Nitrative and oxidative stress in toxicology and disease.

Toxicol Sci 2009 Nov 5;112(1):4-16. Epub 2009 Aug 5.

AstraZeneca R&D Safety Assessment, Alderley Park, UK SK9 1DG.

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http://dx.doi.org/10.1093/toxsci/kfp179DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2769059PMC
November 2009

A minimally invasive, translational biomarker of ketamine-induced neuronal death in rats: microPET Imaging using 18F-annexin V.

Toxicol Sci 2009 Oct 28;111(2):355-61. Epub 2009 Jul 28.

Division of Neurotoxicology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, Arkansas 72079, USA.

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http://dx.doi.org/10.1093/toxsci/kfp167DOI Listing
October 2009

Potential neurotoxicity of ketamine in the developing rat brain.

Toxicol Sci 2009 Mar 6;108(1):149-58. Epub 2009 Jan 6.

Division of Neurotoxicology, National Center for Toxicological Research, U.S. Food & Drug Administration, Jefferson, Arkansas 72079, USA.

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http://dx.doi.org/10.1093/toxsci/kfn270DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2721655PMC
March 2009

The genetic toxicology of methylphenidate hydrochloride in non-human primates.

Mutat Res 2009 Feb 24;673(1):59-66. Epub 2008 Dec 24.

Division of Genetic and Reproductive Toxicology, National Center for Toxicological Research, US Food and Drug Administration, 3900 NCTR Road, Jefferson, AR 72079, United States.

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http://dx.doi.org/10.1016/j.mrgentox.2008.12.001DOI Listing
February 2009

Windows based general PBPK/PD modeling software.

Comput Biol Med 2008 Sep 26;38(9):962-78. Epub 2008 Jul 26.

Department of Chemical Engineering, University of Missouri-Columbia, Columbia, MO 65231, USA.

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http://dx.doi.org/10.1016/j.compbiomed.2008.06.001DOI Listing
September 2008

Protective effects of 7-nitroindazole on ketamine-induced neurotoxicity in rat forebrain culture.

Neurotoxicology 2008 Jul 29;29(4):613-20. Epub 2008 Mar 29.

Division of Neurotoxicology, National Center for Toxicological Research/US Food & Drug Administration, HFT-132 Jefferson, AR, USA.

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http://dx.doi.org/10.1016/j.neuro.2008.03.007DOI Listing
July 2008

Strategies and experimental models for evaluating anesthetics: effects on the developing nervous system.

Anesth Analg 2008 Jun;106(6):1643-58

Division of Neurotoxicology, National Center for Toxicological Research/F3900 NCTR Road, Jefferson, AR 72079-9502, USA.

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http://pdfs.journals.lww.com/anesthesia-analgesia/2008/06000
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http://dx.doi.org/10.1213/ane.ob013e3181732c01DOI Listing
June 2008

Methylphenidate and chromosome damage.

Cancer Lett 2008 Feb 4;260(1-2):216-8. Epub 2007 Dec 4.

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http://dx.doi.org/10.1016/j.canlet.2007.10.017DOI Listing
February 2008

Effect of prolonged ketamine exposure on cardiovascular physiology in pregnant and infant rhesus monkeys (Macaca mulatta).

J Am Assoc Lab Anim Sci 2007 Nov;46(6):21-8

The Bionetics Corporation, National Center for Toxicological Research /FDA, Jefferson, AR, USA.

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November 2007

Systems biology approaches for toxicology.

J Appl Toxicol 2007 May-Jun;27(3):201-17

National Center for Toxicological Research, U S Food and Drug Administration, Jefferson, Arkansas 72079-9502, USA.

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http://dx.doi.org/10.1002/jat.1207DOI Listing
October 2007

Ketamine-induced neuronal cell death in the perinatal rhesus monkey.

Toxicol Sci 2007 Jul 10;98(1):145-58. Epub 2007 Apr 10.

Division of Neurotoxicology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR 72079-0502, USA.

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http://dx.doi.org/10.1093/toxsci/kfm084DOI Listing
July 2007

Postnatal growth considerations for PBPK modeling.

J Toxicol Environ Health A 2007 Jun;70(12):1027-37

Department of Chemical Engineering, University of Missouri-Columbia, Columbia, Missouri, USA.

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http://dx.doi.org/10.1080/15287390601172056DOI Listing
June 2007

The MicroArray Quality Control (MAQC) project shows inter- and intraplatform reproducibility of gene expression measurements.

Authors:
Leming Shi Laura H Reid Wendell D Jones Richard Shippy Janet A Warrington Shawn C Baker Patrick J Collins Francoise de Longueville Ernest S Kawasaki Kathleen Y Lee Yuling Luo Yongming Andrew Sun James C Willey Robert A Setterquist Gavin M Fischer Weida Tong Yvonne P Dragan David J Dix Felix W Frueh Frederico M Goodsaid Damir Herman Roderick V Jensen Charles D Johnson Edward K Lobenhofer Raj K Puri Uwe Schrf Jean Thierry-Mieg Charles Wang Mike Wilson Paul K Wolber Lu Zhang Shashi Amur Wenjun Bao Catalin C Barbacioru Anne Bergstrom Lucas Vincent Bertholet Cecilie Boysen Bud Bromley Donna Brown Alan Brunner Roger Canales Xiaoxi Megan Cao Thomas A Cebula James J Chen Jing Cheng Tzu-Ming Chu Eugene Chudin John Corson J Christopher Corton Lisa J Croner Christopher Davies Timothy S Davison Glenda Delenstarr Xutao Deng David Dorris Aron C Eklund Xiao-hui Fan Hong Fang Stephanie Fulmer-Smentek James C Fuscoe Kathryn Gallagher Weigong Ge Lei Guo Xu Guo Janet Hager Paul K Haje Jing Han Tao Han Heather C Harbottle Stephen C Harris Eli Hatchwell Craig A Hauser Susan Hester Huixiao Hong Patrick Hurban Scott A Jackson Hanlee Ji Charles R Knight Winston P Kuo J Eugene LeClerc Shawn Levy Quan-Zhen Li Chunmei Liu Ying Liu Michael J Lombardi Yunqing Ma Scott R Magnuson Botoul Maqsodi Tim McDaniel Nan Mei Ola Myklebost Baitang Ning Natalia Novoradovskaya Michael S Orr Terry W Osborn Adam Papallo Tucker A Patterson Roger G Perkins Elizabeth H Peters Ron Peterson Kenneth L Philips P Scott Pine Lajos Pusztai Feng Qian Hongzu Ren Mitch Rosen Barry A Rosenzweig Raymond R Samaha Mark Schena Gary P Schroth Svetlana Shchegrova Dave D Smith Frank Staedtler Zhenqiang Su Hongmei Sun Zoltan Szallasi Zivana Tezak Danielle Thierry-Mieg Karol L Thompson Irina Tikhonova Yaron Turpaz Beena Vallanat Christophe Van Stephen J Walker Sue Jane Wang Yonghong Wang Russ Wolfinger Alex Wong Jie Wu Chunlin Xiao Qian Xie Jun Xu Wen Yang Liang Zhang Sheng Zhong Yaping Zong William Slikker

Nat Biotechnol 2006 Sep;24(9):1151-61

National Center for Toxicological Research, US Food and Drug Administration, Jefferson, Arkansas 72079, USA.

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http://dx.doi.org/10.1038/nbt1239DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3272078PMC
September 2006

Blockade of N-methyl-D-aspartate receptors by ketamine produces loss of postnatal day 3 monkey frontal cortical neurons in culture.

Toxicol Sci 2006 May 24;91(1):192-201. Epub 2006 Feb 24.

Division of Neurotoxicology, National Center for Toxicological Research/Food and Drug Administration, Jefferson, Arkansas 72079-0502, USA.

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http://dx.doi.org/10.1093/toxsci/kfj144DOI Listing
May 2006

Behavioral test methods workshop.

Neurotoxicol Teratol 2005 May-Jun;27(3):417-27. Epub 2005 Apr 26.

National Center for Toxicological Research/FDA, Division of Neurotoxicology, 3900 NCTR Rd. Jefferson 72079, United States.

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http://dx.doi.org/10.1016/j.ntt.2005.02.003DOI Listing
August 2005

Biomarkers of adult and developmental neurotoxicity.

Toxicol Appl Pharmacol 2005 Aug;206(2):255-60

Division of Neurotoxicology, National Center for Toxicological Research/FDA, HFT-132, 3900 NCTR Road, Jefferson, AR 72079-9502, USA.

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http://dx.doi.org/10.1016/j.taap.2004.09.022DOI Listing
August 2005

Systems biology/systems toxicology: application to developmental neurotoxicology/neuroprotection.

Ann N Y Acad Sci 2005 Aug;1053:309-10

Division of Neurotoxicology, National Center for Toxicological Research/FDA, 3900 NCTR Road, Jefferson, Arkansas 72079, USA.

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http://dx.doi.org/10.1196/annals.1344.056DOI Listing
August 2005

Improving predictive modeling in pediatric drug development: pharmacokinetics, pharmacodynamics, and mechanistic modeling.

Ann N Y Acad Sci 2005 Aug;1053:505-18

Office of Research, National Center for Toxicological Research/FDA, 3900 NCTR Road, Jefferson, Arkansas 72079-9502, USA.

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http://dx.doi.org/10.1196/annals.1344.044DOI Listing
August 2005

A microarray study of MPP+-treated PC12 Cells: Mechanisms of toxicity (MOT) analysis using bioinformatics tools.

BMC Bioinformatics 2005 Jul 15;6 Suppl 2:S8. Epub 2005 Jul 15.

Division of Neurotoxicology, National Center for Toxicological Research, U.S. Food and Drug Administration, 3900 NCTR Road, Jefferson, Arkansas 72079, USA.

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http://dx.doi.org/10.1186/1471-2105-6-S2-S8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1637031PMC
July 2005

Application of a systems biology approach to developmental neurotoxicology.

Reprod Toxicol 2005 Jan-Feb;19(3):305-19

Division of Neurotoxicology, National Center for Toxicological Research, US Food and Drug Administration, 3900 NCTR Road, Jefferson, AR 72079-9502, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S089062380400190
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http://dx.doi.org/10.1016/j.reprotox.2004.10.003DOI Listing
June 2005

The differential JunB responses to inhibition of succinate dehydrogenase in rat hippocampus and liver.

Neurosci Lett 2005 Jun 28;381(3):354-7. Epub 2005 Mar 28.

Division of Neurotoxicology, FDA/National Center for Toxicological Research, 3900 NCTR Road, Jefferson, AR 72079-9502, USA.

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http://dx.doi.org/10.1016/j.neulet.2005.02.049DOI Listing
June 2005

Thimerosal neurotoxicity is associated with glutathione depletion: protection with glutathione precursors.

Neurotoxicology 2005 Jan;26(1):1-8

Department of Pediatrics, University of Arkansas for Medical Sciences and Arkansas Children's Hospital Research Institute, Little Rock, AR 72202, USA.

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http://dx.doi.org/10.1016/j.neuro.2004.07.012DOI Listing
January 2005

Sex differences in cytochrome P450 1B1, an estrogen-metabolizing enzyme, in the rhesus monkey telencephalon.

J Chem Neuroanat 2005 Jan;29(1):71-80

Division of Neurotoxicology, National Center for Toxicological Research, NCTR/FDA, 3900 NCTR Drive, Jefferson, AR 72079, USA.

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http://dx.doi.org/10.1016/j.jchemneu.2004.09.003DOI Listing
January 2005

Role of the standard deviation in the estimation of benchmark doses with continuous data.

Risk Anal 2004 Dec;24(6):1683-7

Gaylor and Associates, LLC, Little Rock, AR, USA.

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http://dx.doi.org/10.1111/j.0272-4332.2004.559_1.xDOI Listing
December 2004

Introduction.

Authors:
William Slikker

DNA Cell Biol 2004 Oct;23(10):605

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http://dx.doi.org/10.1089/dna.2004.23.605DOI Listing
October 2004