Publications by authors named "William Plunkett"

100Publications

Repair of DNA damage induced by the novel nucleoside analogue CNDAG through homologous recombination.

Cancer Chemother Pharmacol 2020 Apr 18;85(4):661-672. Epub 2020 Feb 18.

Department of Experimental Therapeutics, The University of Texas M. D. Anderson Cancer Center, Houston, TX, 77054, USA.

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http://dx.doi.org/10.1007/s00280-020-04035-xDOI Listing
April 2020

CNDAC-Induced DNA Double-Strand Breaks Cause Aberrant Mitosis Prior to Cell Death.

Mol Cancer Ther 2019 12 9;18(12):2283-2295. Epub 2019 Sep 9.

Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, Texas.

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http://dx.doi.org/10.1158/1535-7163.MCT-18-1380DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7433019PMC
December 2019

Ibrutinib and Venetoclax for First-Line Treatment of CLL.

N Engl J Med 2019 05;380(22):2095-2103

From the Departments of Leukemia (N.J., M. Keating, P.T., A.F., J.B., G.B., K.T., Z.E., T.K., M. Konopleva, Y.A., M.Y., C.D., P.B., M.O., N.P., E.J., K. Sasaki, K. Sondermann, N.C., C.W., A.A., H.K., W.W.), Lymphoma and Myeloma (N.F.), Hematopathology (R.K.-S., K.P., J.J.), Diagnostic Radiology (N.G.), Biostatistics (X.W.), and Experimental Therapeutics (W.P., V.G.), University of Texas M.D. Anderson Cancer Center, Houston.

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http://dx.doi.org/10.1056/NEJMoa1900574DOI Listing
May 2019

Creating novel translation inhibitors to target pro-survival proteins in chronic lymphocytic leukemia.

Leukemia 2019 07 30;33(7):1663-1674. Epub 2019 Jan 30.

Department of Experimental Therapeutics, The University of Texas M.D. Anderson Cancer Center, Houston, TX, USA.

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http://dx.doi.org/10.1038/s41375-018-0364-xDOI Listing
July 2019

Targeting BRCA1/2 deficient ovarian cancer with CNDAC-based drug combinations.

Cancer Chemother Pharmacol 2018 02 30;81(2):255-267. Epub 2017 Nov 30.

Department of Experimental Therapeutics, The University of Texas M. D. Anderson Cancer Center, 1901 East Road, 77054, Houston, TX, USA.

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http://dx.doi.org/10.1007/s00280-017-3483-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5777892PMC
February 2018

TDP1 is Critical for the Repair of DNA Breaks Induced by Sapacitabine, a Nucleoside also Targeting ATM- and BRCA-Deficient Tumors.

Mol Cancer Ther 2017 11 11;16(11):2543-2551. Epub 2017 Aug 11.

Developmental Therapeutics Branch and Laboratory of Molecular Pharmacology, Center for Cancer Research, NCI, NIH, Bethesda, Maryland.

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http://dx.doi.org/10.1158/1535-7163.MCT-17-0110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5971110PMC
November 2017

Mechanism-Based Drug Combinations with the DNA Strand-Breaking Nucleoside Analog CNDAC.

Mol Cancer Ther 2016 10 29;15(10):2302-2313. Epub 2016 Jul 29.

Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, Texas. Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, Texas.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5050117PMC
http://dx.doi.org/10.1158/1535-7163.MCT-15-0801DOI Listing
October 2016

Arginine addiction in AML.

Authors:
William Plunkett

Blood 2015 Jun;125(26):3971-2

UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER.

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http://dx.doi.org/10.1182/blood-2015-05-643411DOI Listing
June 2015

Omacetaxine: a protein translation inhibitor for treatment of chronic myelogenous leukemia.

Clin Cancer Res 2014 Apr 5;20(7):1735-40. Epub 2014 Feb 5.

Authors' Affiliations: Departments of Experimental Therapeutics and Leukemia, The University of Texas MD Anderson Cancer Center, Houston, Texas.

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http://dx.doi.org/10.1158/1078-0432.CCR-13-1283DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4048124PMC
April 2014

Phase I-II clinical trial of oxaliplatin, fludarabine, cytarabine, and rituximab therapy in aggressive relapsed/refractory chronic lymphocytic leukemia or Richter syndrome.

Clin Lymphoma Myeloma Leuk 2013 Oct 27;13(5):568-74. Epub 2013 Jun 27.

Department of Investigational Cancer Therapeutics, Phase I Clinical Trials Program, The University of Texas MD Anderson Cancer Center, Houston, TX. Electronic address:

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http://dx.doi.org/10.1016/j.clml.2013.03.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4180513PMC
October 2013

Sapacitabine, the prodrug of CNDAC, is a nucleoside analog with a unique action mechanism of inducing DNA strand breaks.

Chin J Cancer 2012 Aug 26;31(8):373-80. Epub 2012 Jun 26.

Department of Experimental Therapeutics, University of Texas M. D. Anderson Cancer Center, Houston, TX 77054, USA.

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http://dx.doi.org/10.5732/cjc.012.10077DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3777512PMC
August 2012

Stromal control of cystine metabolism promotes cancer cell survival in chronic lymphocytic leukaemia.

Nat Cell Biol 2012 Feb 19;14(3):276-86. Epub 2012 Feb 19.

Department of Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA.

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http://dx.doi.org/10.1038/ncb2432DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3290742PMC
February 2012

Sapacitabine for cancer.

Expert Opin Investig Drugs 2012 Apr 14;21(4):541-55. Epub 2012 Feb 14.

The University of Texas M.D. Anderson Cancer Center, Department of Experimental Therapeutics, Houston, TX, USA.

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http://dx.doi.org/10.1517/13543784.2012.660249DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3366487PMC
April 2012

Killing of chronic lymphocytic leukemia by the combination of fludarabine and oxaliplatin is dependent on the activity of XPF endonuclease.

Clin Cancer Res 2011 Jul 1;17(14):4731-41. Epub 2011 Jun 1.

Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA.

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http://dx.doi.org/10.1158/1078-0432.CCR-10-2561DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5534342PMC
July 2011

DNA-dependent protein kinase and ataxia telangiectasia mutated (ATM) promote cell survival in response to NK314, a topoisomerase IIα inhibitor.

Mol Pharmacol 2011 Aug 5;80(2):321-7. Epub 2011 May 5.

Department of Experimental Therapeutics, Box 71, The University of Texas M.D. Anderson Cancer Center, 1515 Holcombe Blvd., Houston, TX 77030, USA.

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http://dx.doi.org/10.1124/mol.109.057125DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3141888PMC
August 2011

TRIM24 links a non-canonical histone signature to breast cancer.

Nature 2010 Dec;468(7326):927-32

Department of Biochemistry and Molecular Biology, Program in Genes and Development, Graduate School of Biomedical Sciences, University of Texas M.D. Anderson Cancer Center, Houston, Texas 77030, USA.

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http://dx.doi.org/10.1038/nature09542DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3058826PMC
December 2010

Clofarabine in leukemia.

Expert Rev Hematol 2010 Feb;3(1):15-22

Department of Leukemia, The University of Texas, MD Anderson Cancer Center, 1515 Holcombe Blvd., Houston, TX 77030, USA.

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http://dx.doi.org/10.1586/ehm.09.70DOI Listing
February 2010

Homoharringtonine reduced Mcl-1 expression and induced apoptosis in chronic lymphocytic leukemia.

Blood 2011 Jan 22;117(1):156-64. Epub 2010 Oct 22.

Department of Experimental Therapeutics, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA.

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http://dx.doi.org/10.1182/blood-2010-01-262808DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3037741PMC
January 2011

Responses in mantle cell lymphoma cells to SNS-032 depend on the biological context of each cell line.

Cancer Res 2010 Aug 27;70(16):6587-97. Epub 2010 Jul 27.

Department of Experimental Therapeutics, University of Texas MD Anderson Cancer Center and Graduate School of Biomedical Sciences, University of Texas Houston Health Science Center, Houston, Texas 77030, USA.

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http://cancerres.aacrjournals.org/cgi/doi/10.1158/0008-5472.
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http://dx.doi.org/10.1158/0008-5472.CAN-09-3578DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2929954PMC
August 2010

Formation mechanism of silver nanoparticle 1D microstructures and their hierarchical assembly into 3D superstructures.

Nanoscale 2010 Jan 6;2(1):128-33. Epub 2009 Oct 6.

CNR-Istituto di Struttura della Materia, 00016 Monterotondo St., Italy.

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http://xlink.rsc.org/?DOI=B9NR00072K
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http://dx.doi.org/10.1039/b9nr00072kDOI Listing
January 2010

Strategy to induce apoptosis and circumvent resistance in chronic lymphocytic leukaemia.

Best Pract Res Clin Haematol 2010 Mar;23(1):155-66

Department of Experimental Therapeutics, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA.

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http://dx.doi.org/10.1016/j.beha.2010.01.003DOI Listing
March 2010

Homologous recombination as a resistance mechanism to replication-induced double-strand breaks caused by the antileukemia agent CNDAC.

Blood 2010 Sep 17;116(10):1737-46. Epub 2010 May 17.

Department of Experimental Therapeutics, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA.

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http://dx.doi.org/10.1182/blood-2009-05-220376DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2947394PMC
September 2010

Oral clofarabine in the treatment of patients with higher-risk myelodysplastic syndrome.

J Clin Oncol 2010 Jun 26;28(16):2755-60. Epub 2010 Apr 26.

Department of Leukemia, The University of Texas M. D. Anderson Cancer Center, 1400 Holcombe Blvd., Houston, TX 77230-1402, USA.

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http://dx.doi.org/10.1200/JCO.2009.26.3509DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4872315PMC
June 2010

Intracellular succinylation of 8-chloroadenosine and its effect on fumarate levels.

J Biol Chem 2010 Mar 11;285(11):8022-30. Epub 2010 Jan 11.

Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA.

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http://dx.doi.org/10.1074/jbc.M109.085803DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2832953PMC
March 2010

Phase I clinical and pharmacokinetic study of oral sapacitabine in patients with acute leukemia and myelodysplastic syndrome.

J Clin Oncol 2010 Jan 23;28(2):285-91. Epub 2009 Nov 23.

The University of Texas M. D. Anderson Cancer Center, Department of Leukemia, Unit 428, 1515 Holcombe Blvd, Houston, TX 77030, USA.

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http://dx.doi.org/10.1200/JCO.2009.25.0209DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3340938PMC
January 2010

Targeting DNA repair in chronic lymphocytic leukemia cells with a novel acyclic nucleotide analogue, GS-9219.

Clin Cancer Res 2009 Jun 12;15(11):3760-9. Epub 2009 May 12.

Departments of Experimental Therapeutics and Leukemia, The University of Texas M.D. Anderson Cancer Center, USA.

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http://clincancerres.aacrjournals.org/cgi/doi/10.1158/1078-0
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http://dx.doi.org/10.1158/1078-0432.CCR-08-2848DOI Listing
June 2009

Mechanism of action of SNS-032, a novel cyclin-dependent kinase inhibitor, in chronic lymphocytic leukemia.

Blood 2009 May 20;113(19):4637-45. Epub 2009 Feb 20.

Department of Experimental Therapeutics, The University of Texas M. D. Anderson Cancer Center, Houston, TX 77030, USA.

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http://dx.doi.org/10.1182/blood-2008-12-190256DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2680368PMC
May 2009

ATM and the Mre11-Rad50-Nbs1 complex respond to nucleoside analogue-induced stalled replication forks and contribute to drug resistance.

Cancer Res 2008 Oct;68(19):7947-55

Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston Graduate School of Biomedical Sciences, Houston, Texas 77030, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-08-0971DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2631429PMC
October 2008

Effective elimination of fludarabine-resistant CLL cells by PEITC through a redox-mediated mechanism.

Blood 2008 Sep 23;112(5):1912-22. Epub 2008 Jun 23.

Department of Molecular Pathology, The University of Texas M. D. Anderson Cancer Center, Houston, TX 77030, USA.

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http://dx.doi.org/10.1182/blood-2008-04-149815DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2518893PMC
September 2008

Repair of 2'-C-cyano-2'-deoxy-1-beta-D-arabino-pentofuranosylcytosine-induced DNA single-strand breaks by transcription-coupled nucleotide excision repair.

Cancer Res 2008 May;68(10):3881-9

Department of Experimental Therapeutics, The University of Texas M. D. Anderson Cancer Center, Houston, Texas, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-07-6885DOI Listing
May 2008

Polyadenylation inhibition by the triphosphates of deoxyadenosine analogues.

Leuk Res 2008 Oct 22;32(10):1573-81. Epub 2008 Apr 22.

Department of Experimental Therapeutics, UT MD Anderson Cancer Center, Houston, TX 77030, USA.

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http://dx.doi.org/10.1016/j.leukres.2008.03.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4048126PMC
October 2008

Phase I trial of nelarabine in indolent leukemias.

J Clin Oncol 2008 Mar;26(7):1098-105

Department of Experimental Therapeutics, Box 71, The University of Texas M.D. Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA.

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http://dx.doi.org/10.1200/JCO.2007.14.1986DOI Listing
March 2008

Ataxia-telangiectasia and Rad3-related and DNA-dependent protein kinase cooperate in G2 checkpoint activation by the DNA strand-breaking nucleoside analogue 2'-C-cyano-2'-deoxy-1-beta-D-arabino-pentofuranosylcytosine.

Mol Cancer Ther 2008 Jan;7(1):133-42

Department of Experimental Therapeutics, The University of Texas M. D. Anderson Cancer Center, Box 71, 1515 Holcombe Boulevard, Houston, TX 77030, USA.

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http://dx.doi.org/10.1158/1535-7163.MCT-07-0416DOI Listing
January 2008

miRNAs and their potential for use against cancer and other diseases.

Future Oncol 2007 Oct;3(5):521-37

Ohio State University, Department of Molecular Virology, Immunology & Medical Genetics and Comprehensive Cancer Center, Columbus, OH 43210, USA.

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http://dx.doi.org/10.2217/14796694.3.5.521DOI Listing
October 2007

Pharmacogenetics of deoxycytidine kinase: identification and characterization of novel genetic variants.

J Pharmacol Exp Ther 2007 Dec 12;323(3):935-45. Epub 2007 Sep 12.

Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, 332 North Lauderdale St., Memphis, TN 38105, USA.

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http://jpet.aspetjournals.org/cgi/doi/10.1124/jpet.107.12859
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http://dx.doi.org/10.1124/jpet.107.128595DOI Listing
December 2007

The role of DNA repair in chronic lymphocytic leukemia pathogenesis and chemotherapy resistance.

Curr Oncol Rep 2007 Sep;9(5):361-7

Department of Experimental Therapeutics, Unit 71, The University of Texas M.D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA.

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http://link.springer.com/content/pdf/10.1007/s11912-007-0048
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http://dx.doi.org/10.1007/s11912-007-0048-6DOI Listing
September 2007

Inhibition of topoisomerase IIalpha and G2 cell cycle arrest by NK314, a novel benzo[c]phenanthridine currently in clinical trials.

Mol Cancer Ther 2007 May;6(5):1501-8

Department of Experimental Therapeutics, Box 71, The University of Texas M.D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA.

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http://dx.doi.org/10.1158/1535-7163.MCT-06-0780DOI Listing
May 2007

H2AX phosphorylation marks gemcitabine-induced stalled replication forks and their collapse upon S-phase checkpoint abrogation.

Mol Cancer Ther 2007 Apr 3;6(4):1239-48. Epub 2007 Apr 3.

Department of Experimental Therapeutics, The University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA.

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http://dx.doi.org/10.1158/1535-7163.MCT-06-0633DOI Listing
April 2007

A sequential blockade strategy for the design of combination therapies to overcome oncogene addiction in chronic myelogenous leukemia.

Cancer Res 2006 Nov;66(22):10959-66

Department of Experimental Therapeutics, University of Texas M.D. Anderson Cancer Center, Houston, Texas, USA.

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http://cancerres.aacrjournals.org/cgi/doi/10.1158/0008-5472.
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http://dx.doi.org/10.1158/0008-5472.CAN-06-1216DOI Listing
November 2006

Clofarabine and nelarabine: two new purine nucleoside analogs.

Curr Opin Oncol 2006 Nov;18(6):584-90

Department of Experimental Therapeutics, University of Texas MD Anderson Cancer Center, Houston, Texas, USA.

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http://dx.doi.org/10.1097/01.cco.0000245326.65152.afDOI Listing
November 2006

Fludarabine increases oxaliplatin cytotoxicity in normal and chronic lymphocytic leukemia lymphocytes by suppressing interstrand DNA crosslink removal.

Blood 2006 Dec 5;108(13):4187-93. Epub 2006 Sep 5.

Department of Experimental Therapeutics Unit 71, The University of Texas M D Anderson Cancer Center, Houston, TX 77030-4009, USA.

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http://dx.doi.org/10.1182/blood-2006-05-023259DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1895455PMC
December 2006

Clinical and pharmacokinetic study of clofarabine in chronic lymphocytic leukemia: strategy for treatment.

Clin Cancer Res 2006 Jul;12(13):4011-7

Department of Experimental Therapeutics, The University of Texas M.D. Anderson Cancer Center, Houston, Texas 77030, USA.

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http://dx.doi.org/10.1158/1078-0432.CCR-05-2664DOI Listing
July 2006

Mdm2 inhibitor Nutlin-3a induces p53-mediated apoptosis by transcription-dependent and transcription-independent mechanisms and may overcome Atm-mediated resistance to fludarabine in chronic lymphocytic leukemia.

Blood 2006 Aug 16;108(3):993-1000. Epub 2006 Mar 16.

Department of Blood and Marrow Transplantation, Section of Molecular Hematology and Therapy, The University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Blvd, Houston, 77030, USA.

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http://dx.doi.org/10.1182/blood-2005-12-5148DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1895860PMC
August 2006

Pharmacodynamics of cytarabine alone and in combination with 7-hydroxystaurosporine (UCN-01) in AML blasts in vitro and during a clinical trial.

Blood 2006 Mar 17;107(6):2517-24. Epub 2005 Nov 17.

Department of Experimental Therapeutics, The University of Texas M. D. Anderson Cancer Center, Houston, TX 77030, USA.

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http://dx.doi.org/10.1182/blood-2005-08-3351DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1895741PMC
March 2006

Molecular basis for G2 arrest induced by 2'-C-cyano-2'-deoxy-1-beta-D-arabino-pentofuranosylcytosine and consequences of checkpoint abrogation.

Cancer Res 2005 Aug;65(15):6874-81

Department of Experimental Therapeutics, The University of Texas M.D. Anderson Cancer Center, Houston, Texas 77030, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-05-0288DOI Listing
August 2005

2-Chlorodeoxyadenosine and cytarabine combination therapy for idiopathic hypereosinophilic syndrome.

Cancer 2005 Aug;104(3):541-6

Department of Leukemia, The University of Texas M. D. Anderson Cancer Center, 1400 Holcombe Boulevard, Houston, TX 77030, USA.

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http://dx.doi.org/10.1002/cncr.21186DOI Listing
August 2005

Transcription inhibition by flavopiridol: mechanism of chronic lymphocytic leukemia cell death.

Blood 2005 Oct 21;106(7):2513-9. Epub 2005 Jun 21.

Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.

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http://dx.doi.org/10.1182/blood-2005-04-1678DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1895272PMC
October 2005

Bis(pivaloyloxymethyl) thymidine 5'-phosphate is a cell membrane-permeable precursor of thymidine 5'-phosphate in thymidine kinase deficient CCRF CEM cells.

Biochem Pharmacol 2005 May;69(9):1307-13

The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD 21231, USA.

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http://dx.doi.org/10.1016/j.bcp.2005.02.008DOI Listing
May 2005

The role of clofarabine in hematologic and solid malignancies--development of a next-generation nucleoside analog.

Cancer 2005 May;103(10):1985-95

Department of Leukemia, The University of Texas M. D. Anderson Cancer Center, Houston, Texas 77230-1402, USA.

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http://dx.doi.org/10.1002/cncr.21005DOI Listing
May 2005

A pharmacological study of celecoxib and gemcitabine in patients with advanced pancreatic cancer.

Cancer Chemother Pharmacol 2005 Jun 22;55(6):559-64. Epub 2005 Feb 22.

Department of Gastrointestinal Medical Oncology, Unit 426, The University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA.

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http://dx.doi.org/10.1007/s00280-004-0916-9DOI Listing
June 2005

Clofarabine in adult acute leukemias: clinical success and pharmacokinetics.

Nucleosides Nucleotides Nucleic Acids 2004 Oct;23(8-9):1417-23

Department of Experimental Therapeutics, UT M D Anderson Cancer Center, Houston, Texas, USA.

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http://dx.doi.org/10.1081/NCN-200027650DOI Listing
October 2004

Pharmacokinetics and pharmacodynamics of plasma clofarabine and cellular clofarabine triphosphate in patients with acute leukemias.

Clin Cancer Res 2003 Dec;9(17):6335-42

Department of Experimental Therapeutics, The University of Texas M. D. Anderson Cancer Center, Houston, Texas, 77030, USA.

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December 2003

Mechanisms of apoptosis induction by nucleoside analogs.

Oncogene 2003 Dec;22(56):9063-74

The Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.

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http://dx.doi.org/10.1038/sj.onc.1207229DOI Listing
December 2003

Clofarabine, a novel nucleoside analog, is active in pediatric patients with advanced leukemia.

Blood 2004 Feb 9;103(3):784-9. Epub 2003 Oct 9.

Department of Hematology-Oncology, St Jude Children's Research Hospital, 332 N Lauderdale St, Memphis, TN 38105, USA.

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http://dx.doi.org/10.1182/blood-2003-06-2122DOI Listing
February 2004

Activation of a p53-mediated apoptotic pathway in quiescent lymphocytes after the inhibition of DNA repair by fludarabine.

Clin Cancer Res 2003 Aug;9(8):3204-12

Department of Experimental Therapeutics, The University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030, USA.

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August 2003

Randomized phase II comparison of dose-intense gemcitabine: thirty-minute infusion and fixed dose rate infusion in patients with pancreatic adenocarcinoma.

J Clin Oncol 2003 Sep 28;21(18):3402-8. Epub 2003 Jul 28.

University of California San Francisco Comprehensive Cancer Center, 1600 Divisadero St, B726, UC Box 1770, San Francisco, CA 94115, USA.

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http://dx.doi.org/10.1200/JCO.2003.09.140DOI Listing
September 2003

Cisplatin-induced ubiquitination of RNA polymerase II large subunit and suppression of induction by 7-hydroxystaurosporine (UCN-01).

Oncol Rep 2003 Sep-Oct;10(5):1489-95

Department of Laboratory Medicine, Unit 54, The University of Texas M.D. Anderson Cancer Center, Houston, TX 77030, USA.

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April 2004

Inhibition of mitochondrial respiration: a novel strategy to enhance drug-induced apoptosis in human leukemia cells by a reactive oxygen species-mediated mechanism.

J Biol Chem 2003 Sep 9;278(39):37832-9. Epub 2003 Jul 9.

Department of Molecular Pathology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030, USA.

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http://dx.doi.org/10.1074/jbc.M301546200DOI Listing
September 2003