William O C Cookson

William O C Cookson

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William O C Cookson

Publications by authors named "William O C Cookson"

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The Genetics and Genomics of Asthma.

Annu Rev Genomics Hum Genet 2018 08;19:223-246

National Heart and Lung Institute, Imperial College London, London SW7 2AZ, United Kingdom; email: , ,

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https://www.annualreviews.org/doi/10.1146/annurev-genom-0831
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http://dx.doi.org/10.1146/annurev-genom-083117-021651DOI Listing
August 2018

A novel role for ciliary function in atopy: ADGRV1 and DNAH5 interactions.

J Allergy Clin Immunol 2018 05 18;141(5):1659-1667.e11. Epub 2017 Sep 18.

Genetic Variation and Human Diseases Unit, INSERM, Université Paris Diderot, Université Sorbonne Paris Cité, Paris, France.

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http://dx.doi.org/10.1016/j.jaci.2017.06.050DOI Listing
May 2018

DNA methylation in childhood asthma: an epigenome-wide meta-analysis.

Lancet Respir Med 2018 05 26;6(5):379-388. Epub 2018 Feb 26.

GRIAC research institute Groningen, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands; Department of Pediatric Pulmonology and Pediatric Allergy, Beatrix Children's Hospital, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands. Electronic address:

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http://dx.doi.org/10.1016/S2213-2600(18)30052-3DOI Listing
May 2018

New opportunities for managing acute and chronic lung infections.

Nat Rev Microbiol 2018 02 24;16(2):111-120. Epub 2017 Oct 24.

Asmarley Centre for Genomic Medicine, National Heart and Lung Institute, Imperial College London, Dovehouse Street, London SW3 6LY, UK.

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http://dx.doi.org/10.1038/nrmicro.2017.122DOI Listing
February 2018

Multiancestry association study identifies new asthma risk loci that colocalize with immune-cell enhancer marks.

Authors:
Florence Demenais Patricia Margaritte-Jeannin Kathleen C Barnes William O C Cookson Janine Altmüller Wei Ang R Graham Barr Terri H Beaty Allan B Becker John Beilby Hans Bisgaard Unnur Steina Bjornsdottir Eugene Bleecker Klaus Bønnelykke Dorret I Boomsma Emmanuelle Bouzigon Christopher E Brightling Myriam Brossard Guy G Brusselle Esteban Burchard Kristin M Burkart Andrew Bush Moira Chan-Yeung Kian Fan Chung Alexessander Couto Alves John A Curtin Adnan Custovic Denise Daley Johan C de Jongste Blanca E Del-Rio-Navarro Kathleen M Donohue Liesbeth Duijts Celeste Eng Johan G Eriksson Martin Farrall Yuliya Fedorova Bjarke Feenstra Manuel A Ferreira Maxim B Freidin Zofia Gajdos Jim Gauderman Ulrike Gehring Frank Geller Jon Genuneit Sina A Gharib Frank Gilliland Raquel Granell Penelope E Graves Daniel F Gudbjartsson Tari Haahtela Susan R Heckbert Dick Heederik Joachim Heinrich Markku Heliövaara John Henderson Blanca E Himes Hiroshi Hirose Joel N Hirschhorn Albert Hofman Patrick Holt Jouke Hottenga Thomas J Hudson Jennie Hui Medea Imboden Vladimir Ivanov Vincent W V Jaddoe Alan James Christer Janson Marjo-Riitta Jarvelin Deborah Jarvis Graham Jones Ingileif Jonsdottir Pekka Jousilahti Michael Kabesch Mika Kähönen David B Kantor Alexandra S Karunas Elza Khusnutdinova Gerard H Koppelman Anita L Kozyrskyj Eskil Kreiner Michiaki Kubo Rajesh Kumar Ashish Kumar Mikko Kuokkanen Lies Lahousse Tarja Laitinen Catherine Laprise Mark Lathrop Susanne Lau Young-Ae Lee Terho Lehtimäki Sébastien Letort Albert M Levin Guo Li Liming Liang Laura R Loehr Stephanie J London Daan W Loth Ani Manichaikul Ingo Marenholz Fernando J Martinez Melanie C Matheson Rasika A Mathias Kenji Matsumoto Hamdi Mbarek Wendy L McArdle Mads Melbye Erik Melén Deborah Meyers Sven Michel Hamida Mohamdi Arthur W Musk Rachel A Myers Maartje A E Nieuwenhuis Emiko Noguchi George T O'Connor Ludmila M Ogorodova Cameron D Palmer Aarno Palotie Julie E Park Craig E Pennell Göran Pershagen Alexey Polonikov Dirkje S Postma Nicole Probst-Hensch Valery P Puzyrev Benjamin A Raby Olli T Raitakari Adaikalavan Ramasamy Stephen S Rich Colin F Robertson Isabelle Romieu Muhammad T Salam Veikko Salomaa Vivi Schlünssen Robert Scott Polina A Selivanova Torben Sigsgaard Angela Simpson Valérie Siroux Lewis J Smith Maria Solodilova Marie Standl Kari Stefansson David P Strachan Bruno H Stricker Atsushi Takahashi Philip J Thompson Gudmar Thorleifsson Unnur Thorsteinsdottir Carla M T Tiesler Dara G Torgerson Tatsuhiko Tsunoda André G Uitterlinden Ralf J P van der Valk Amaury Vaysse Sailaja Vedantam Andrea von Berg Erika von Mutius Judith M Vonk Johannes Waage Nick J Wareham Scott T Weiss Wendy B White Magnus Wickman Elisabeth Widén Gonneke Willemsen L Keoki Williams Inge M Wouters James J Yang Jing Hua Zhao Miriam F Moffatt Carole Ober Dan L Nicolae

Nat Genet 2018 01 22;50(1):42-53. Epub 2017 Dec 22.

Departments of Statistics, Human Genetics and Medicine, Section of Genetic Medicine, University of Chicago, Chicago, IL, USA.

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http://www.nature.com/articles/s41588-017-0014-7
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http://dx.doi.org/10.1038/s41588-017-0014-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5901974PMC
January 2018

An epigenome-wide association study of total serum IgE in Hispanic children.

J Allergy Clin Immunol 2017 Aug 6;140(2):571-577. Epub 2017 Jan 6.

Division of Pediatric Pulmonary Medicine, Allergy, and Immunology, Children's Hospital of Pittsburgh of UPMC, University of Pittsburgh, Pittsburgh, Pa. Electronic address:

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http://dx.doi.org/10.1016/j.jaci.2016.11.030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5500449PMC
August 2017

Pulmonary ORMDL3 is critical for induction of Alternaria-induced allergic airways disease.

J Allergy Clin Immunol 2017 May 10;139(5):1496-1507.e3. Epub 2016 Sep 10.

Inflammation, Repair & Development Section, National Heart and Lung Institute, Imperial College London, London, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/j.jaci.2016.07.033DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5415707PMC
May 2017

Vitamin D levels and susceptibility to asthma, elevated immunoglobulin E levels, and atopic dermatitis: A Mendelian randomization study.

PLoS Med 2017 05 9;14(5):e1002294. Epub 2017 May 9.

Centre for Clinical Epidemiology, Department of Epidemiology, Lady Davis Institute for Medical Research, Jewish General Hospital, McGill University, Montréal, Canada.

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http://dx.doi.org/10.1371/journal.pmed.1002294DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5423551PMC
May 2017

Outside In: Sequencing the Lung Microbiome.

Am J Respir Crit Care Med 2015 Aug;192(4):403-4

1 National Heart and Lung Institute Imperial College London London, United Kingdom.

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http://dx.doi.org/10.1164/rccm.201506-1138EDDOI Listing
August 2015

iGWAS: Integrative Genome-Wide Association Studies of Genetic and Genomic Data for Disease Susceptibility Using Mediation Analysis.

Genet Epidemiol 2015 Jul 22;39(5):347-56. Epub 2015 May 22.

Departments of Epidemiology and Biostatistics, Harvard School of Public Health, Boston, Massachusetts, United States of America.

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http://dx.doi.org/10.1002/gepi.21905DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4544880PMC
July 2015

eQTL mapping identifies insertion- and deletion-specific eQTLs in multiple tissues.

Nat Commun 2015 May 8;6:6821. Epub 2015 May 8.

1] Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts 02115, USA [2] Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts 02115, USA.

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http://www.nature.com/articles/ncomms7821
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http://dx.doi.org/10.1038/ncomms7821DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4929061PMC
May 2015

Grasping nettles: cellular heterogeneity and other confounders in epigenome-wide association studies.

Hum Mol Genet 2014 Sep 13;23(R1):R83-8. Epub 2014 Jun 13.

National Heart and Lung Institute, Imperial College London, London SW3 6LY, UK

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http://dx.doi.org/10.1093/hmg/ddu284DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4170720PMC
September 2014

Predicting DNA methylation level across human tissues.

Nucleic Acids Res 2014 Apr 20;42(6):3515-28. Epub 2014 Jan 20.

Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA, College of Information Science and Technology, Dalian Maritime University, Dalian, Liaoning Province 116026, China, Cardiovascular Epidemiology Research Unit, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA, Department of Environmental Health, Harvard School of Public Health, Boston, MA 02115, USA, National Heart and Lung Institute, Imperial College, London SW3 6LY, UK, Department of Clinical Sciences and Community, University of Milan, Milan 20122, Italy, Division of Cardiac Surgery, Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA and Department of Biostatistics, Harvard School of Public Health, Boston, MA 02115, USA.

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http://dx.doi.org/10.1093/nar/gkt1380DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3973306PMC
April 2014

Novel childhood asthma genes interact with in utero and early-life tobacco smoke exposure.

J Allergy Clin Immunol 2014 Mar 6;133(3):885-8. Epub 2013 Dec 6.

Department of Epidemiology, University of Groningen, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands; Groningen Research Institute for Asthma and COPD (GRIAC), University of Groningen, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.jaci.2013.08.049DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3969577PMC
March 2014

Sequencing the human microbiome in health and disease.

Hum Mol Genet 2013 Oct 13;22(R1):R88-94. Epub 2013 Aug 13.

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http://dx.doi.org/10.1093/hmg/ddt398DOI Listing
October 2013

Bedside to gene and back in idiopathic pulmonary fibrosis.

N Engl J Med 2013 Jun 21;368(23):2228-30. Epub 2013 May 21.

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http://dx.doi.org/10.1056/NEJMe1304758DOI Listing
June 2013

A cross-platform analysis of 14,177 expression quantitative trait loci derived from lymphoblastoid cell lines.

Genome Res 2013 Apr 23;23(4):716-26. Epub 2013 Jan 23.

Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1101/gr.142521.112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3613588PMC
April 2013

Integrating pathway analysis and genetics of gene expression for genome-wide association study of basal cell carcinoma.

Hum Genet 2012 Apr 18;131(4):615-23. Epub 2011 Oct 18.

Clinical Research Program, Department of Dermatology, Harvard Medical School, Brigham and Women's Hospital, Boston, MA 02115, USA.

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http://dx.doi.org/10.1007/s00439-011-1107-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3303995PMC
April 2012

Genetic and genomic approaches to asthma: new insights for the origins.

Curr Opin Pulm Med 2012 Jan;18(1):6-13

Molecular Genetics Group, Division of Respiratory Sciences, Imperial College London, Dovehouse Street, London, UK.

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http://dx.doi.org/10.1097/MCP.0b013e32834dc532DOI Listing
January 2012

Genetics of complex airway disease.

Proc Am Thorac Soc 2011 May;8(2):149-53

National Heart and Lung Institute, London SW3 6LY, UK.

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http://pats.atsjournals.org/cgi/doi/10.1513/pats.201101-003M
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http://dx.doi.org/10.1513/pats.201101-003MSDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3131831PMC
May 2011

A large-scale, consortium-based genomewide association study of asthma.

N Engl J Med 2010 Sep;363(13):1211-1221

National Heart and Lung Institute, Imperial College (M.F.M., W.O.C.M.C.), the Division of Community Health Sciences, St. George's, University of London (D.P.S.), and Royal Brompton and Harefield NHS Foundation Trust (W.O.C.M.C.) - all in London; Commissariat à l'Energie Atomique, Institut de Génomique, Centre National de Génotypage, Evry, France (I.G.G., S.H., M.L.); INSERM, Unité 946, Fondation Jean-Dausset-Centre d'Etude du Polymorphisme Humain (CEPH) (F.D., E.B.), Fondation Jean Dausset-CEPH (F.D., E.B., M.L.), and Université Paris Diderot Paris 7, Institut Universitaire d'Hématologie (F.D., E.B.) - all in Paris; University Children's Hospital, Asthma and Allergy Department, Ludwig Maximilians University, Munich, Germany (E.M.); and Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom (M.F.).

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http://dx.doi.org/10.1056/NEJMoa0906312DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4260321PMC
September 2010

Asthma and chitinases.

N Engl J Med 2008 Apr 9;358(16):1725-6. Epub 2008 Apr 9.

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http://dx.doi.org/10.1056/NEJMe0802072DOI Listing
April 2008

The role of atopic sensitization in flexural eczema: findings from the International Study of Asthma and Allergies in Childhood Phase Two.

J Allergy Clin Immunol 2008 Jan 5;121(1):141-147.e4. Epub 2007 Nov 5.

Centre of Evidence Based Dermatology and the Centre for Population Sciences, Institute of Clinical Research, University of Nottingham, Nottingham, United Kingdom.

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http://dx.doi.org/10.1016/j.jaci.2007.08.066DOI Listing
January 2008

A genome-wide association study of global gene expression.

Nat Genet 2007 Oct 16;39(10):1202-7. Epub 2007 Sep 16.

National Heart and Lung Institute, Imperial College London, London SW3 6LY, UK.

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http://www.nature.com/articles/ng2109
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http://dx.doi.org/10.1038/ng2109DOI Listing
October 2007

Filaggrin mutations in children with severe atopic dermatitis.

J Invest Dermatol 2007 Jul 15;127(7):1667-72. Epub 2007 Feb 15.

National Heart and Lung Institute, Molecular Genetics Division, Imperial College, London, UK.

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http://dx.doi.org/10.1038/sj.jid.5700739DOI Listing
July 2007

State of the art. Genetics and genomics of chronic obstructive pulmonary disease.

Proc Am Thorac Soc 2006 Aug;3(6):473-5

National Heart and Lung Institute, Imperial College, London, UK.

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http://pats.atsjournals.org/cgi/doi/10.1513/pats.200603-036M
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http://dx.doi.org/10.1513/pats.200603-036MSDOI Listing
August 2006

The genetics of atopic dermatitis.

J Allergy Clin Immunol 2006 Jul 19;118(1):24-34; quiz 35-6. Epub 2006 May 19.

Wellcome Trust Centre for Human Genetics, University of Oxford, UK.

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http://dx.doi.org/10.1016/j.jaci.2006.03.037DOI Listing
July 2006

Investigation of the chromosome 17q25 PSORS2 locus in atopic dermatitis.

J Invest Dermatol 2006 Mar;126(3):603-6

Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.

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http://dx.doi.org/10.1038/sj.jid.5700108DOI Listing
March 2006

Association between a complex insertion/deletion polymorphism in NOD1 (CARD4) and susceptibility to inflammatory bowel disease.

Hum Mol Genet 2005 May 24;14(10):1245-50. Epub 2005 Mar 24.

Thw Wellcome Trust Centre for Human Genetics, University of Oxford, Headington, UK.

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http://dx.doi.org/10.1093/hmg/ddi135DOI Listing
May 2005

NOD1 variation, immunoglobulin E and asthma.

Hum Mol Genet 2005 Apr 17;14(7):935-41. Epub 2005 Feb 17.

Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK.

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http://dx.doi.org/10.1093/hmg/ddi087DOI Listing
April 2005

The genetics of psoriasis, psoriatic arthritis and atopic dermatitis.

Hum Mol Genet 2004 Apr;13 Spec No 1:R43-55

Department of Genetics, Pediatrics and Medicine, Washington University School of Medicine, St Louis, MO 63110, USA.

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http://dx.doi.org/10.1093/hmg/ddh094DOI Listing
April 2004

LD mapping of maternally and non-maternally derived alleles and atopy in FcepsilonRI-beta.

Hum Mol Genet 2003 Oct 27;12(20):2577-85. Epub 2003 Aug 27.

Wellcome Trust Centre for Human Genetics, University of Oxford, Headington, UK.

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http://dx.doi.org/10.1093/hmg/ddg290DOI Listing
October 2003

Benign asbestos pleural diseases.

Curr Opin Pulm Med 2003 Jul;9(4):266-71

Osler Chest Unit, Churchill Hospital, Oxford, UK, and Department of Medicine, University of Western Australia, Perth, Australia.

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July 2003

Atopy, respiratory function and HLA-DR in Aboriginal Australians.

Hum Mol Genet 2003 Mar;12(6):625-30

Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Headington, Oxford OX3 7BN, UK.

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March 2003

The genetics of atopic dermatitis.

Curr Opin Allergy Clin Immunol 2002 Oct;2(5):383-7

Wellcome Trust Center for Human Genetics, Oxford, UK.

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October 2002

Positive association to IgE levels and a physical map of the 13q14 atopy locus.

Eur J Hum Genet 2002 Apr;10(4):266-70

The Welcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Headington, OX3 7BN, UK.

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http://dx.doi.org/10.1038/sj.ejhg.5200801DOI Listing
April 2002

A detailed genetic map of the chromosome 7 bronchial hyper-responsiveness locus.

Eur J Hum Genet 2002 Mar;10(3):177-82

Asthma Genetics Group, Wellcome Trust Centre for Human Genetics, University of Oxford, Headington, Oxford, UK.

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http://www.nature.com/articles/5200787
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http://dx.doi.org/10.1038/sj.ejhg.5200787DOI Listing
March 2002