William N Hunter

William N Hunter

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William N Hunter

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The thermodynamic profile and molecular interactions of a C(9)-cytisine derivative-binding acetylcholine-binding protein from Aplysia californica.

Acta Crystallogr F Struct Biol Commun 2020 Feb 3;76(Pt 2):74-80. Epub 2020 Feb 3.

Division of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee, Dow Street, Dundee DD1 5EH, Scotland.

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http://dx.doi.org/10.1107/S2053230X20001168DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7010356PMC
February 2020

A Structural Rationale for N-Methylbicuculline Acting as a Promiscuous Competitive Antagonist of Inhibitory Pentameric Ligand-Gated Ion Channels.

Chembiochem 2019 Dec 20. Epub 2019 Dec 20.

Division of Biological Chemistry and Drug Discovery School of Life Sciences, University of Dundee, Dow St, Dundee, DD1 5EH, UK.

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http://dx.doi.org/10.1002/cbic.201900680DOI Listing
December 2019

Burkholderia pseudomallei d-alanine-d-alanine ligase; detailed characterisation and assessment of a potential antibiotic drug target.

FEBS J 2019 Nov 16;286(22):4509-4524. Epub 2019 Jul 16.

Division of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee, UK.

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http://dx.doi.org/10.1111/febs.14976DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6899670PMC
November 2019

Engineering a surrogate human heteromeric α/β glycine receptor orthosteric site exploiting the structural homology and stability of acetylcholine-binding protein.

IUCrJ 2019 Nov 4;6(Pt 6):1014-1023. Epub 2019 Sep 4.

Division of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee, Dundee DD1 5EH, Scotland.

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http://dx.doi.org/10.1107/S205225251901114XDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6830221PMC
November 2019

The structure of lipopolysaccharide transport protein B (LptB) from Burkholderia pseudomallei.

Acta Crystallogr F Struct Biol Commun 2019 Apr 13;75(Pt 4):227-232. Epub 2019 Mar 13.

Division of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee, Dundee DD1 5EH, Scotland.

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http://dx.doi.org/10.1107/S2053230X19001778DOI Listing
April 2019

An assessment of three human methylenetetrahydrofolate dehydrogenase/cyclohydrolase-ligand complexes following further refinement.

Acta Crystallogr F Struct Biol Commun 2019 Mar 20;75(Pt 3):148-152. Epub 2019 Feb 20.

Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dundee DD1 5EH, Scotland.

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http://dx.doi.org/10.1107/S2053230X18018083DOI Listing
March 2019

Amino acid substitutions in the human homomeric β GABA receptor that enable activation by GABA.

J Biol Chem 2019 02 13;294(7):2375-2385. Epub 2018 Dec 13.

The Institute of Academic Anaesthesia, Division of Systems Medicine, School of Medicine, Ninewells Hospital, University of Dundee, Dundee DD1 9SY, Scotland, United Kingdom

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http://www.jbc.org/lookup/doi/10.1074/jbc.RA118.006229
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http://dx.doi.org/10.1074/jbc.RA118.006229DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6378970PMC
February 2019

Structure and activity of ChiX: a peptidoglycan hydrolase required for chitinase secretion by .

Biochem J 2018 01 23;475(2):415-428. Epub 2018 Jan 23.

School of Life Sciences, University of Dundee, Dundee DD1 5EH, U.K.

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http://dx.doi.org/10.1042/BCJ20170633DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5778951PMC
January 2018

An Improved Model of the Trypanosoma brucei CTP Synthetase Glutaminase Domain-Acivicin Complex.

ChemMedChem 2017 04 31;12(8):577-579. Epub 2017 Mar 31.

Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dundee, DD1 5EH, Scotland, UK.

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http://dx.doi.org/10.1002/cmdc.201700118DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5413811PMC
April 2017

Open and compressed conformations of Francisella tularensis ClpP.

Proteins 2017 01 20;85(1):188-194. Epub 2016 Nov 20.

Division of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee, Dundee, United Kingdom.

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http://dx.doi.org/10.1002/prot.25197DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5225881PMC
January 2017

EssC: domain structures inform on the elusive translocation channel in the Type VII secretion system.

Biochem J 2016 07 29;473(13):1941-52. Epub 2016 Apr 29.

School of Life Sciences, University of Dundee, Dow Street, Dundee DD1 5EH, U.K.

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http://dx.doi.org/10.1042/BCJ20160257DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4925161PMC
July 2016

Membrane interactions and self-association of components of the Ess/Type VII secretion system of Staphylococcus aureus.

FEBS Lett 2016 Feb 3;590(3):349-57. Epub 2016 Feb 3.

Divisions of Molecular Microbiology, School of Life Sciences, University of Dundee, Dundee, UK.

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http://dx.doi.org/10.1002/1873-3468.12065DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4949537PMC
February 2016

The structure of tubulin-binding cofactor A from Leishmania major infers a mode of association during the early stages of microtubule assembly.

Acta Crystallogr F Struct Biol Commun 2015 May 21;71(Pt 5):539-46. Epub 2015 Apr 21.

Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dow Street, Dundee DD1 5EH, Scotland.

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http://dx.doi.org/10.1107/S2053230X15000990DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4427162PMC
May 2015

Crystal structure of the C-terminal domain of tubulin-binding cofactor C from Leishmania major.

Mol Biochem Parasitol 2015 May 14;201(1):26-30. Epub 2015 May 14.

Division of Biological Chemistry & Drug Discovery, College of Life Sciences, University of Dundee, Dundee DD1 5EH, Scotland, UK. Electronic address:

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http://dx.doi.org/10.1016/j.molbiopara.2015.05.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4539340PMC
May 2015

Structures of bacterial kynurenine formamidase reveal a crowded binuclear zinc catalytic site primed to generate a potent nucleophile.

Biochem J 2014 Sep;462(3):581-9

*Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dow Street, Dundee DD1 5EH, U.K.

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http://biochemj.org/lookup/doi/10.1042/BJ20140511
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http://dx.doi.org/10.1042/BJ20140511DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4243253PMC
September 2014

Structure-based design and synthesis of antiparasitic pyrrolopyrimidines targeting pteridine reductase 1.

J Med Chem 2014 Aug 29;57(15):6479-94. Epub 2014 Jul 29.

WestCHEM Department of Pure and Applied Chemistry, University of Strathclyde , 295 Cathedral Street, Glasgow G1 1XL, United Kingdom.

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http://dx.doi.org/10.1021/jm500483bDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4136963PMC
August 2014

Structure of the SCAN domain of human paternally expressed gene 3 protein.

PLoS One 2013 23;8(7):e69538. Epub 2013 Jul 23.

Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dundee, United Kingdom.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0069538PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3720700PMC
March 2014

How the structure of the large subunit controls function in an oxygen-tolerant [NiFe]-hydrogenase.

Biochem J 2014 Mar;458(3):449-58

*Division of Molecular Microbiology, College of Life Sciences, University of Dundee, Dundee DD1 5EH, Scotland, U.K.

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http://dx.doi.org/10.1042/BJ20131520DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3940037PMC
March 2014

High-resolution structure of the M14-type cytosolic carboxypeptidase from Burkholderia cenocepacia refined exploiting PDB_REDO strategies.

Acta Crystallogr D Biol Crystallogr 2014 Feb 29;70(Pt 2):279-89. Epub 2014 Jan 29.

Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dundee DD1 5EH, Scotland.

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http://dx.doi.org/10.1107/S1399004713026801DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3940198PMC
February 2014

Crystal structures of IspF from Plasmodium falciparum and Burkholderia cenocepacia: comparisons inform antimicrobial drug target assessment.

BMC Struct Biol 2014 Jan 10;14. Epub 2014 Jan 10.

Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dundee, DD1 5EH, UK.

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http://dx.doi.org/10.1186/1472-6807-14-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3927217PMC
January 2014

Structural basis for type VI secreted peptidoglycan DL-endopeptidase function, specificity and neutralization in Serratia marcescens.

Acta Crystallogr D Biol Crystallogr 2013 Dec 19;69(Pt 12):2468-82. Epub 2013 Nov 19.

Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dundee DD1 5EH, Scotland.

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http://dx.doi.org/10.1107/S0907444913022725DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3852654PMC
December 2013

Two high-resolution structures of the human E3 ubiquitin ligase Siah1.

Acta Crystallogr Sect F Struct Biol Cryst Commun 2013 Dec 28;69(Pt 12):1339-43. Epub 2013 Nov 28.

Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dundee DD1 5EH, Scotland.

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http://dx.doi.org/10.1107/S1744309113031448DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3855715PMC
December 2013

The architecture of Trypanosoma brucei tubulin-binding cofactor B and implications for function.

FEBS J 2013 Jul 24;280(14):3270-80. Epub 2013 May 24.

Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dundee, UK.

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http://dx.doi.org/10.1111/febs.12308DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3806363PMC
July 2013

Structure of diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase from Acinetobacter baumannii.

Acta Crystallogr Sect F Struct Biol Cryst Commun 2013 Jun 23;69(Pt 6):611-7. Epub 2013 May 23.

Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dundee DD1 5EH, Scotland.

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http://dx.doi.org/10.1107/S174430911301292XDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3668577PMC
June 2013

The architecture of EssB, an integral membrane component of the type VII secretion system.

Structure 2013 Apr 14;21(4):595-603. Epub 2013 Mar 14.

College of Life Sciences, University of Dundee, Dow Street, Dundee DD1 5EH, UK.

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http://dx.doi.org/10.1016/j.str.2013.02.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3694306PMC
April 2013

Structure of Pseudomonas aeruginosa inosine 5'-monophosphate dehydrogenase.

Acta Crystallogr Sect F Struct Biol Cryst Commun 2013 Mar 22;69(Pt 3):243-7. Epub 2013 Feb 22.

Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dow Street, Dundee DD1 5EH, Scotland.

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http://dx.doi.org/10.1107/S1744309113002352DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3606566PMC
March 2013

Acinetobacter baumannii FolD ligand complexes --potent inhibitors of folate metabolism and a re-evaluation of the structure of LY374571.

FEBS J 2012 Dec 5;279(23):4350-60. Epub 2012 Nov 5.

Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dundee, UK.

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http://doi.wiley.com/10.1111/febs.12025
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http://dx.doi.org/10.1111/febs.12025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3655515PMC
December 2012

New secreted toxins and immunity proteins encoded within the Type VI secretion system gene cluster of Serratia marcescens.

Mol Microbiol 2012 Nov 27;86(4):921-36. Epub 2012 Sep 27.

Division of Molecular Microbiology, College of Life Sciences, University of Dundee, Dundee, UK.

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http://dx.doi.org/10.1111/mmi.12028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3533786PMC
November 2012

IspE inhibitors identified by a combination of in silico and in vitro high-throughput screening.

PLoS One 2012 25;7(4):e35792. Epub 2012 Apr 25.

Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dundee, United Kingdom.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0035792PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3340893PMC
September 2012

Structure of Leishmania major cysteine synthase.

Acta Crystallogr Sect F Struct Biol Cryst Commun 2012 Jul 22;68(Pt 7):738-43. Epub 2012 Jun 22.

Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dundee DD1 5EH, Scotland.

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http://scripts.iucr.org/cgi-bin/paper?S1744309112019124
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http://dx.doi.org/10.1107/S1744309112019124DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3388911PMC
July 2012

Leishmania TDR1 structure, a unique trimeric glutathione transferase capable of deglutathionylation and antimonial prodrug activation.

Proc Natl Acad Sci U S A 2012 Jul 2;109(29):11693-8. Epub 2012 Jul 2.

Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dundee DD1 5EH, United Kingdom.

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http://www.pnas.org/cgi/doi/10.1073/pnas.1202593109
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http://dx.doi.org/10.1073/pnas.1202593109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3406863PMC
July 2012

The crystal structure of Leishmania major N(5),N(10)-methylenetetrahydrofolate dehydrogenase/cyclohydrolase and assessment of a potential drug target.

Mol Biochem Parasitol 2012 Feb 15;181(2):178-85. Epub 2011 Nov 15.

Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dundee DD1 5EH, UK.

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http://dx.doi.org/10.1016/j.molbiopara.2011.11.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3368264PMC
February 2012

Conserved signal peptide recognition systems across the prokaryotic domains.

Biochemistry 2012 Feb 13;51(8):1678-86. Epub 2012 Feb 13.

College of Life Sciences, University of Dundee, Dundee DD1 5EH, Scotland, United Kingdom.

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http://dx.doi.org/10.1021/bi201852dDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3290102PMC
February 2012

Isoprenoid precursor biosynthesis offers potential targets for drug discovery against diseases caused by apicomplexan parasites.

Authors:
William N Hunter

Curr Top Med Chem 2011 ;11(16):2048-59

Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, UK.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3466564PMC
http://dx.doi.org/10.2174/156802611796575867DOI Listing
December 2011

The structure of Serratia marcescens Lip, a membrane-bound component of the type VI secretion system.

Acta Crystallogr D Biol Crystallogr 2011 Dec 18;67(Pt 12):1065-72. Epub 2011 Nov 18.

College of Life Sciences, University of Dundee, Dundee DD1 5EH, Scotland.

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http://dx.doi.org/10.1107/S0907444911046300DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3225178PMC
December 2011

Syringyl lignin is unaltered by severe sinapyl alcohol dehydrogenase suppression in tobacco.

Plant Cell 2011 Dec 9;23(12):4492-506. Epub 2011 Dec 9.

Division of Plant Sciences, College of Life Sciences, University of Dundee at the James Hutton Institute, Invergowrie, Dundee, United Kingdom.

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http://dx.doi.org/10.1105/tpc.111.089037DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3269879PMC
December 2011

Crystal structures of Burkholderia cenocepacia dihydropteroate synthase in the apo-form and complexed with the product 7,8-dihydropteroate.

BMC Struct Biol 2011 May 9;11:21. Epub 2011 May 9.

Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dow Street, Dundee, DD1 5EH, UK.

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http://dx.doi.org/10.1186/1472-6807-11-21DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3098144PMC
May 2011

The role of Co²+ in the crystallization of human SENP1 and comments on the limitations of automated refinement protocols.

Acta Crystallogr Sect F Struct Biol Cryst Commun 2011 Apr 24;67(Pt 4):442-5. Epub 2011 Mar 24.

Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dundee DD1 5EH, Scotland.

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http://dx.doi.org/10.1107/S1744309111005835DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3080145PMC
April 2011

Exploiting the high-resolution crystal structure of Staphylococcus aureus MenH to gain insight into enzyme activity.

BMC Struct Biol 2011 Apr 22;11:19. Epub 2011 Apr 22.

Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dundee, DD1 5EH, UK.

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http://dx.doi.org/10.1186/1472-6807-11-19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3097144PMC
April 2011

Structure of recombinant Leishmania donovani pteridine reductase reveals a disordered active site.

Acta Crystallogr Sect F Struct Biol Cryst Commun 2011 Jan 21;67(Pt 1):33-7. Epub 2010 Dec 21.

Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dundee DD1 5EH, Scotland.

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http://dx.doi.org/10.1107/S174430911004724XDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3079966PMC
January 2011

Crystal structure of Leishmania major ADP-ribosylation factor-like 1 and a classification of related GTPase family members in this Kinetoplastid.

Mol Biochem Parasitol 2010 Dec 27;174(2):141-4. Epub 2010 Aug 27.

Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dundee, UK.

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http://dx.doi.org/10.1016/j.molbiopara.2010.08.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3065712PMC
December 2010

High-resolution structures of Trypanosoma brucei pteridine reductase ligand complexes inform on the placement of new molecular entities in the active site of a potential drug target.

Acta Crystallogr D Biol Crystallogr 2010 Dec 16;66(Pt 12):1334-40. Epub 2010 Nov 16.

Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dundee DD15EH, Scotland.

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http://dx.doi.org/10.1107/S0907444910040886DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3655514PMC
December 2010

Structure and reactivity of Bacillus subtilis MenD catalyzing the first committed step in menaquinone biosynthesis.

J Mol Biol 2010 Aug 18;401(2):253-64. Epub 2010 Jun 18.

Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dow Street, Dundee DD1 5EH, UK.

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http://dx.doi.org/10.1016/j.jmb.2010.06.025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2914249PMC
August 2010

Structure of Staphylococcus aureus adenylosuccinate lyase (PurB) and assessment of its potential as a target for structure-based inhibitor discovery.

Acta Crystallogr D Biol Crystallogr 2010 Aug 9;66(Pt 8):881-8. Epub 2010 Jul 9.

Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dundee DD15EH, Scotland.

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http://dx.doi.org/10.1107/S0907444910020081DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2917274PMC
August 2010

Structure of Trypanosoma brucei glutathione synthetase: domain and loop alterations in the catalytic cycle of a highly conserved enzyme.

Mol Biochem Parasitol 2010 Apr 4;170(2):93-9. Epub 2010 Jan 4.

Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dow Street, Dundee, DD1 5EH, United Kingdom.

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http://dx.doi.org/10.1016/j.molbiopara.2009.12.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2845819PMC
April 2010

A triclinic crystal form of Escherichia coli 4-diphosphocytidyl-2C-methyl-D-erythritol kinase and reassessment of the quaternary structure.

Acta Crystallogr Sect F Struct Biol Cryst Commun 2010 Mar 23;66(Pt 3):237-41. Epub 2010 Feb 23.

Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dundee DD1 5EH, Scotland.

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http://dx.doi.org/10.1107/S1744309109054591DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2833027PMC
March 2010

Specificity and mechanism of Acinetobacter baumanii nicotinamidase: implications for activation of the front-line tuberculosis drug pyrazinamide.

Angew Chem Int Ed Engl 2009 ;48(48):9176-9

Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dow Street, Dundee DD1 5EH, UK.

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http://dx.doi.org/10.1002/anie.200903407DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3465764PMC
January 2010

The ethanolamine branch of the Kennedy pathway is essential in the bloodstream form of Trypanosoma brucei.

Mol Microbiol 2009 Sep 23;73(5):826-43. Epub 2009 Jun 23.

Division of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee, Dundee, Scotland, UK.

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http://dx.doi.org/10.1111/j.1365-2958.2009.06764.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2784872PMC
September 2009

Structure-based ligand design and the promise held for antiprotozoan drug discovery.

Authors:
William N Hunter

J Biol Chem 2009 May 22;284(18):11749-53. Epub 2008 Dec 22.

Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dow Street, Dundee DD1 5EH, Scotland, United Kingdom.

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http://dx.doi.org/10.1074/jbc.R800072200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2673241PMC
May 2009

Geobacillus stearothermophilus 6-phosphogluconate dehydrogenase complexed with 6-phosphogluconate.

Acta Crystallogr Sect F Struct Biol Cryst Commun 2009 May 24;65(Pt 5):450-4. Epub 2009 Apr 24.

University of Dundee, Scotland, UK.

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http://dx.doi.org/10.1107/S1744309109012767DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2675582PMC
May 2009

Diversity oriented syntheses of fused pyrimidines designed as potential antifolates.

Org Biomol Chem 2009 May 6;7(9):1829-42. Epub 2009 Mar 6.

WestCHEM, Department of Pure & Applied Chemistry, University of Strathclyde, 295 Cathedral Street, Glasgow, G1 1XL, Scotland.

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http://dx.doi.org/10.1039/b818339bDOI Listing
May 2009

A structure-based approach to ligand discovery for 2C-methyl-D-erythritol-2,4-cyclodiphosphate synthase: a target for antimicrobial therapy.

J Med Chem 2009 Apr;52(8):2531-42

Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dow Street, Dundee, DD1 5EH, Scotland, United Kingdom.

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http://dx.doi.org/10.1021/jm801475nDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2669732PMC
April 2009

Specificity and reactivity in menaquinone biosynthesis: the structure of Escherichia coli MenD (2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1-carboxylate synthase).

J Mol Biol 2008 Dec 1;384(5):1353-68. Epub 2008 Nov 1.

Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dundee, DD1 5EH, UK.

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http://dx.doi.org/10.1016/j.jmb.2008.10.048DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3656419PMC
December 2008

Structure of Staphylococcus aureus EsxA suggests a contribution to virulence by action as a transport chaperone and/or adaptor protein.

J Mol Biol 2008 Nov 27;383(3):603-14. Epub 2008 Aug 27.

Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dundee, UK.

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http://dx.doi.org/10.1016/j.jmb.2008.08.047DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3465917PMC
November 2008

Biochemical characterization of the initial steps of the Kennedy pathway in Trypanosoma brucei: the ethanolamine and choline kinases.

Biochem J 2008 Oct;415(1):135-44

Division of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee, Dundee DD1 5EH, Scotland, UK.

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http://dx.doi.org/10.1042/BJ20080435DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2552378PMC
October 2008

Inhibitors of the kinase IspE: structure-activity relationships and co-crystal structure analysis.

Org Biomol Chem 2008 Aug 2;6(15):2719-30. Epub 2008 Jun 2.

Laboratorium für Organische Chemie, ETH Zürich, HCI, CH-8093, Zürich, Switzerland.

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August 2008

Leishmania trypanothione synthetase-amidase structure reveals a basis for regulation of conflicting synthetic and hydrolytic activities.

J Biol Chem 2008 Jun 17;283(25):17672-80. Epub 2008 Apr 17.

Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dow Street, Dundee DD1 5EH, United Kingdom.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2427367PMC
June 2008

Crystal structures of Toxoplasma gondii pterin-4a-carbinolamine dehydratase and comparisons with mammalian and parasite orthologues.

Mol Biochem Parasitol 2008 Apr 15;158(2):131-8. Epub 2007 Dec 15.

Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dundee DD1 5EH, UK.

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http://dx.doi.org/10.1016/j.molbiopara.2007.12.002DOI Listing
April 2008

Discovery of potent pteridine reductase inhibitors to guide antiparasite drug development.

Proc Natl Acad Sci U S A 2008 Feb 1;105(5):1448-53. Epub 2008 Feb 1.

Dipartimento di Scienze Farmaceutiche, Università di Modena e Reggio Emilia, Via Campi 183, 41100 Modena, Italy.

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http://dx.doi.org/10.1073/pnas.0704384105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2234164PMC
February 2008

Characterization of the Mycobacterium tuberculosis 4-diphosphocytidyl-2-C-methyl-D-erythritol synthase: potential for drug development.

J Bacteriol 2007 Dec 5;189(24):8922-7. Epub 2007 Oct 5.

Mycobacteria Research Laboratories, Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO 80523, USA.

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http://dx.doi.org/10.1128/JB.00925-07DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2168624PMC
December 2007

Structure of Staphylococcus aureus1,4-dihydroxy-2-naphthoyl-CoA synthase (MenB) in complex with acetoacetyl-CoA.

Acta Crystallogr Sect F Struct Biol Cryst Commun 2007 Nov 20;63(Pt 11):908-13. Epub 2007 Oct 20.

Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dundee DD1 5EH, Tayside, Scotland.

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http://dx.doi.org/10.1107/S1744309107047720DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2339762PMC
November 2007

The structure of Mycobacteria 2C-methyl-D-erythritol-2,4-cyclodiphosphate synthase, an essential enzyme, provides a platform for drug discovery.

BMC Struct Biol 2007 Oct 23;7:68. Epub 2007 Oct 23.

Division of Biological Chemistry and Molecular Microbiology, College of Life Sciences, University of Dundee, Dundee DD1 5EH, UK.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2151065PMC
October 2007

Crystal structures of Trypanosoma brucei and Staphylococcus aureus mevalonate diphosphate decarboxylase inform on the determinants of specificity and reactivity.

J Mol Biol 2007 Aug 4;371(2):540-53. Epub 2007 Jun 4.

Division of Biological Chemistry and Molecular Microbiology, College of Life Sciences, University of Dundee, Dundee DD1 5EH, UK.

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August 2007

The non-mevalonate pathway of isoprenoid precursor biosynthesis.

Authors:
William N Hunter

J Biol Chem 2007 Jul 18;282(30):21573-7. Epub 2007 Apr 18.

Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Scotland, UK.

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July 2007

Structures of Staphylococcus aureus D-tagatose-6-phosphate kinase implicate domain motions in specificity and mechanism.

J Biol Chem 2007 Jul 25;282(27):19948-57. Epub 2007 Apr 25.

Macromolecular Crystallography Group, European Synchrotron Radiation Facility, 38043 Grenoble, France.

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July 2007

Nucleotide substrate recognition by UDP-N-acetylglucosamine acyltransferase (LpxA) in the first step of lipid A biosynthesis.

J Mol Biol 2007 Jun 21;369(2):305-12. Epub 2007 Mar 21.

Division of Biological Chemistry and Molecular Microbiology, College of Life Sciences, University of Dundee, Dundee DD1 5EH, UK.

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June 2007

Structure and reactivity of LpxD, the N-acyltransferase of lipid A biosynthesis.

Proc Natl Acad Sci U S A 2007 Mar 5;104(11):4321-6. Epub 2007 Mar 5.

Division of Biological Chemistry and Molecular Microbiology, School of Life Sciences, University of Dundee, Dundee DD1 5EH, United Kingdom.

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http://dx.doi.org/10.1073/pnas.0606356104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1810333PMC
March 2007

Structure, substrate recognition and reactivity of Leishmania major mevalonate kinase.

BMC Struct Biol 2007 Mar 30;7:20. Epub 2007 Mar 30.

Division of Biological Chemistry and Molecular Microbiology, School of Life Sciences, University of Dundee, Dundee, UK.

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http://dx.doi.org/10.1186/1472-6807-7-20DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1851959PMC
March 2007

Enantioselective synthesis of C3 fluoro-MEP.

Org Biomol Chem 2007 Jan 10;5(1):97-102. Epub 2006 Nov 10.

School of Life Sciences, University of Dundee, DD1 5EH, UK.

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http://dx.doi.org/10.1039/b613656gDOI Listing
January 2007

The nucleotide-binding site of Aquifex aeolicus LpxC.

Acta Crystallogr Sect F Struct Biol Cryst Commun 2006 Nov 25;62(Pt 11):1082-6. Epub 2006 Oct 25.

Division of Biological Chemistry and Molecular Microbiology, College of Life Sciences, University of Dundee, Dundee DD1 5EH, Scotland, UK.

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http://dx.doi.org/10.1107/S1744309106041893DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2225228PMC
November 2006

Trypanosoma brucei UDP-galactose-4'-epimerase in ternary complex with NAD+ and the substrate analogue UDP-4-deoxy-4-fluoro-alpha-D-galactose.

Acta Crystallogr Sect F Struct Biol Cryst Commun 2006 Sep 11;62(Pt 9):829-34. Epub 2006 Aug 11.

Division of Biological Chemistry and Molecular Microbiology, School of Life Sciences, University of Dundee, Dundee DD1 5EH, Scotland.

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http://dx.doi.org/10.1107/S1744309106028740DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2242870PMC
September 2006

Structure and reactivity of Trypanosoma brucei pteridine reductase: inhibition by the archetypal antifolate methotrexate.

Mol Microbiol 2006 Sep;61(6):1457-68

Division of Biological Chemistry and Molecular Microbiology, School of Life Sciences, University of Dundee, Dundee DD1 5EH, UK.

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http://dx.doi.org/10.1111/j.1365-2958.2006.05332.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1618733PMC
September 2006

The crystal structure of a plant 3-ketoacyl-CoA thiolase reveals the potential for redox control of peroxisomal fatty acid beta-oxidation.

J Mol Biol 2006 Jun 29;359(2):347-57. Epub 2006 Mar 29.

Division of Biological Chemistry and Molecular Microbiology, School of Life Sciences, University of Dundee, Dundee DD1 5EH, UK.

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http://dx.doi.org/10.1016/j.jmb.2006.03.032DOI Listing
June 2006

High-resolution complex of papain with remnants of a cysteine protease inhibitor derived from Trypanosoma brucei.

Acta Crystallogr Sect F Struct Biol Cryst Commun 2006 Jun 5;62(Pt 6):504-8. Epub 2006 May 5.

Division of Biological Chemistry and Molecular Microbiology, School of Life Sciences, University of Dundee, Dundee DD1 5EH, Scotland.

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http://dx.doi.org/10.1107/S1744309106014849DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2243108PMC
June 2006

Recombinant human PPAR-beta/delta ligand-binding domain is locked in an activated conformation by endogenous fatty acids.

J Mol Biol 2006 Mar 4;356(4):1005-13. Epub 2006 Jan 4.

Division of Biological Chemistry and Molecular Microbiology, School of Life Sciences, University of Dundee, Dundee DD1 5EH, UK.

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March 2006

High-resolution structure of recombinant Trichomonas vaginalis thioredoxin.

Acta Crystallogr D Biol Crystallogr 2006 Feb 18;62(Pt 2):216-20. Epub 2006 Jan 18.

Department of Chemistry, Biotechnology Center, State University of Ponta Grossa, Ponta Grossa, Paraná, Brazil.

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http://scripts.iucr.org/cgi-bin/paper?S0907444905039946
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February 2006

Reevaluation of the PPAR-beta/delta ligand binding domain model reveals why it exhibits the activated form.

Mol Cell 2006 Jan;21(1):1-2

Division of Biological Chemistry and Molecular Microbiology, School of Life Sciences, University of Dundee, Dundee DD1 5EH, United Kingdom.

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http://dx.doi.org/10.1016/j.molcel.2005.12.001DOI Listing
January 2006

Structure and reactivity of hydroxypropylphosphonic acid epoxidase in fosfomycin biosynthesis by a cation- and flavin-dependent mechanism.

Proc Natl Acad Sci U S A 2005 Oct 26;102(40):14221-6. Epub 2005 Sep 26.

Division of Biological Chemistry and Molecular Microbiology, School of Life Sciences, University of Dundee, Dundee DD1 5EH, United Kingdom.

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http://www.pnas.org/cgi/doi/10.1073/pnas.0504314102
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1234900PMC
October 2005

Structures of Leishmania major pteridine reductase complexes reveal the active site features important for ligand binding and to guide inhibitor design.

J Mol Biol 2005 Sep;352(1):105-16

Division of Biological Chemistry and Molecular Microbiology, School of Life Sciences, University of Dundee, Dundee DD1 5EH, UK.

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http://beverleylab.wustl.edu/PDFs/166.%20%20Schuttelkopf%20e
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http://dx.doi.org/10.1016/j.jmb.2005.06.076DOI Listing
September 2005

A double mutation of Escherichia coli2C-methyl-D-erythritol-2,4-cyclodiphosphate synthase disrupts six hydrogen bonds with, yet fails to prevent binding of, an isoprenoid diphosphate.

Acta Crystallogr Sect F Struct Biol Cryst Commun 2005 Jul 30;61(Pt 7):625-9. Epub 2005 Jun 30.

Division of Biological Chemistry and Molecular Microbiology, School of Life Sciences, University of Dundee, Dundee DD1 5EH, Scotland.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1952448PMC
July 2005

A preliminary crystallographic analysis of the putative mevalonate diphosphate decarboxylase from Trypanosoma brucei.

Acta Crystallogr Sect F Struct Biol Cryst Commun 2005 Jun 1;61(Pt 6):581-4. Epub 2005 Jun 1.

Division of Biological Chemistry and Molecular Microbiology, School of Life Sciences, University of Dundee, Dundee DD1 5EH, Scotland.

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http://dx.doi.org/10.1107/S1744309105014594DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1952329PMC
June 2005

Initiating a crystallographic analysis of recombinant (S)-2-hydroxypropylphosphonic acid epoxidase from Streptomyces wedmorensis.

Acta Crystallogr Sect F Struct Biol Cryst Commun 2005 May 28;61(Pt 5):534-6. Epub 2005 Apr 28.

Division of Biological Chemistry and Molecular Microbiology, School of Life Sciences, University of Dundee, Dundee DD1 5EH, Scotland.

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http://dx.doi.org/10.1107/S1744309105012376DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1952317PMC
May 2005

The identification of isoprenoids that bind in the intersubunit cavity of Escherichia coli 2C-methyl-D-erythritol-2,4-cyclodiphosphate synthase by complementary biophysical methods.

Acta Crystallogr D Biol Crystallogr 2005 Jan 17;61(Pt 1):45-52. Epub 2004 Dec 17.

Division of Biological Chemistry and Molecular Microbiology, School of Life Sciences, University of Dundee, Dundee DD1 5EH, Scotland.

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http://dx.doi.org/10.1107/S0907444904025971DOI Listing
January 2005