William MacNee

William MacNee

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William MacNee

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Beta-Blockers in COPD - A Controversy Resolved?

Authors:
William MacNee

N Engl J Med 2019 Oct 20. Epub 2019 Oct 20.

From the University of Edinburgh Medical School, Edinburgh.

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http://dx.doi.org/10.1056/NEJMe1912664DOI Listing
October 2019

Role of accelerated aging in limb muscle wasting of patients with COPD.

Int J Chron Obstruct Pulmon Dis 2018 25;13:1987-1998. Epub 2018 Jun 25.

ELEGI Colt Laboratory, MRC Centre for Inflammation Research, The Queen's Medical Research Institute, University of Edinburgh, Edinburgh, UK,

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http://dx.doi.org/10.2147/COPD.S155952DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6022820PMC
January 2019

Exploring the concept of need in people with very severe chronic obstructive pulmonary disease: a qualitative study.

BMJ Support Palliat Care 2018 Dec 26;8(4):468-474. Epub 2015 Aug 26.

Allergy and Respiratory Research Group, Usher Institute of Medical Informatics and Population Health Sciences, University of Edinburgh. Edinburgh, UK.

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http://dx.doi.org/10.1136/bmjspcare-2015-000904DOI Listing
December 2018

Purpose of the Conference: The 2018 Transatlantic Conference on Lung Diseases.

Ann Am Thorac Soc 2018 11;15(Suppl 3):S139

4 Tulane University New Orleans, Louisiana.

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http://dx.doi.org/10.1513/AnnalsATS.201810-675AWDOI Listing
November 2018

Purpose of the Conference: The 2017 Transatlantic Conference on Lung Diseases.

Ann Am Thorac Soc 2017 11;14(Suppl_5):S313

4 Tulane University New Orleans, Louisiana.

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http://dx.doi.org/10.1513/AnnalsATS.201711-858AWDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5946628PMC
November 2017

Physical activity in patients with COPD: the impact of comorbidities.

Expert Rev Respir Med 2017 09 20;11(9):685-698. Epub 2017 Jul 20.

a ELEGI and COLT Laboratories , Queen's Medical Research Institute, The University of Edinburgh , Edinburgh , UK.

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http://dx.doi.org/10.1080/17476348.2017.1354699DOI Listing
September 2017

Ectopic fat accumulation in patients with COPD: an ECLIPSE substudy.

Int J Chron Obstruct Pulmon Dis 2017 31;12:451-460. Epub 2017 Jan 31.

Research Centre, Institut universitaire de cardiologie et de pneumologie de Québec, Université Laval, Québec, QC.

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http://dx.doi.org/10.2147/COPD.S124750DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5293362PMC
August 2017

2D-DIGE proteomic analysis of vastus lateralis from COPD patients with low and normal fat free mass index and healthy controls.

Respir Res 2017 05 3;18(1):81. Epub 2017 May 3.

ELEGI Colt Laboratory, Centre for Inflammation Research, The Queen's Medical Research Institute, University of Edinburgh, 47 Little France Crescent, Edinburgh, EH16 4TJ, Scotland, UK.

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http://dx.doi.org/10.1186/s12931-017-0525-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5415759PMC
May 2017

Genetic loci associated with chronic obstructive pulmonary disease overlap with loci for lung function and pulmonary fibrosis.

Nat Genet 2017 Mar 6;49(3):426-432. Epub 2017 Feb 6.

Channing Division of Network Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1038/ng.3752DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5381275PMC
March 2017

Role of Inflammation and Oxidative Stress in the Pathology of Ageing in COPD: Potential Therapeutic Interventions.

COPD 2017 02 13;14(1):122-135. Epub 2016 Sep 13.

a MRC Centre for Inflammation Research, Queens Medical Research Institute , 47 little France Crescent Edinburgh, United Kingdom.

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https://www.tandfonline.com/doi/full/10.1080/15412555.2016.1
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http://dx.doi.org/10.1080/15412555.2016.1214948DOI Listing
February 2017

Diagnosis, assessment, and phenotyping of COPD: beyond FEV₁.

Int J Chron Obstruct Pulmon Dis 2016 19;11 Spec Iss:3-12. Epub 2016 Feb 19.

MRC Centre for Inflammation Research, The Queen's Medical Research Institute, University of Edinburgh, Edinburgh, UK.

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https://www.dovepress.com/diagnosis-assessment-and-phenotypi
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http://dx.doi.org/10.2147/COPD.S85976DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4765947PMC
December 2016

Is Chronic Obstructive Pulmonary Disease an Accelerated Aging Disease?

Authors:
William MacNee

Ann Am Thorac Soc 2016 12;13 Suppl 5:S429-S437

Queen's Medical Research Institute, The University of Edinburgh, Edinburgh, United Kingdom.

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http://dx.doi.org/10.1513/AnnalsATS.201602-124AWDOI Listing
December 2016

Purpose of the Conference: 2016 Transatlantic Airway Conference.

Ann Am Thorac Soc 2016 12;13 Suppl 5:S395

4 University of Pittsburgh Pittsburgh, Pennsylvania.

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http://dx.doi.org/10.1513/AnnalsATS.201611-900AWDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5946651PMC
December 2016

Age-dependent elastin degradation is enhanced in chronic obstructive pulmonary disease.

Eur Respir J 2016 10 1;48(4):1215-1218. Epub 2016 Sep 1.

MRC/University of Edinburgh Centre for Inflammation Research, Queen's Medical Research Institute, Edinburgh, UK.

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http://dx.doi.org/10.1183/13993003.01125-2016DOI Listing
October 2016

Dynamic (4D) CT perfusion offers simultaneous functional and anatomical insights into pulmonary embolism resolution.

Eur J Radiol 2016 Oct 26;85(10):1883-1890. Epub 2016 Aug 26.

Clinical Research Imaging Centre, Queen's Medical Research Institute, University of Edinburgh, 47 Little France Crescent, Edinburgh EH16 4TJ, United Kingdom.

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http://dx.doi.org/10.1016/j.ejrad.2016.08.018DOI Listing
October 2016

Determinants of exercise-induced oxygen desaturation including pulmonary emphysema in COPD: Results from the ECLIPSE study.

Respir Med 2016 10 25;119:87-95. Epub 2016 Aug 25.

Department of Research and Education, CIRO+, Centre of Expertise for Chronic Organ Failure, Horn, The Netherlands; REVAL - Rehabilitation Research Center, BIOMED - Biomedical Research Institute, Faculty of Medicine and Life Sciences, Hasselt University, Diepenbeek, Belgium. Electronic address:

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http://dx.doi.org/10.1016/j.rmed.2016.08.023DOI Listing
October 2016

Interventions to modify physical activity in patients with COPD: a systematic review.

Eur Respir J 2016 07 21;48(1):69-81. Epub 2016 Apr 21.

ELEGI and COLT Laboratories, The Queen's Medical Research Institute, The University of Edinburgh, Edinburgh, UK

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http://dx.doi.org/10.1183/13993003.01744-2015DOI Listing
July 2016

Computed tomography-derived pathological phenotypes in COPD.

Authors:
William MacNee

Eur Respir J 2016 07;48(1):10-3

University of Edinburgh/MRC Centre for Inflammation Research, Queen's Medical Research Institute, Edinburgh, UK

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http://dx.doi.org/10.1183/13993003.00958-2016DOI Listing
July 2016

Small Airway Disease or Emphysema: Which Is More Important in Lung Function and FEV1 Decline? An Old Story with a New Twist.

Am J Respir Crit Care Med 2016 07;194(2):129-30

2 Department of Radiology Royal Infirmary of Edinburgh Edinburgh, Scotland, United Kingdom.

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http://dx.doi.org/10.1164/rccm.201602-0197EDDOI Listing
July 2016

A review of the most common patient-reported outcomes in COPD--revisiting current knowledge and estimating future challenges.

Int J Chron Obstruct Pulmon Dis 2015 7;10:725-38. Epub 2015 Apr 7.

Patient Reported Outcome Center of Excellence, Global Market Access, Primary Care Business Unit, Pfizer, Tadworth, United Kingdom.

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http://dx.doi.org/10.2147/COPD.S77368DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4396518PMC
February 2016

Continuous fat-free mass decline in COPD: fact or fiction?

Eur Respir J 2015 Nov 17;46(5):1496-8. Epub 2015 Sep 17.

Dept of Research and Education, CIRO, Horn, The Netherlands Maastricht University Medical Center, Maastricht, The Netherlands.

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http://dx.doi.org/10.1183/13993003.00692-2015DOI Listing
November 2015

Purpose of the Conference: 2015 Transatlantic Airway Conference.

Ann Am Thorac Soc 2015 Nov;12 Suppl 2:S111

4 University of Pittsburgh Pittsburgh, Pennsylvania.

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http://dx.doi.org/10.1513/AnnalsATS.201505-264AWDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5467081PMC
November 2015

Prognostic value of variables derived from the six-minute walk test in patients with COPD: Results from the ECLIPSE study.

Respir Med 2015 Sep 25;109(9):1138-46. Epub 2015 Jun 25.

Department of Research and Education; CIRO+, Centre of Expertise for Chronic Organ Failure, Horn, The Netherlands; REVAL - Rehabilitation Research Center, BIOMED - Biomedical Research Institute, Faculty of Medicine and Life Sciences, Hasselt University, Diepenbeek, Belgium.

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http://dx.doi.org/10.1016/j.rmed.2015.06.013DOI Listing
September 2015

Should we treat chronic obstructive pulmonary disease as a cardiovascular disease?

Expert Rev Respir Med 2015 Aug 18;9(4):459-72. Epub 2015 Jul 18.

Edinburgh Lung and the Environment Group Initiative (ELEGI), Centre for Inflammation Research, Queens Medical Research Institute, Edinburgh, UK.

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http://dx.doi.org/10.1586/17476348.2015.1070099DOI Listing
August 2015

Combination of erythromycin and dexamethasone improves corticosteroid sensitivity induced by CSE through inhibiting PI3K-δ/Akt pathway and increasing GR expression.

Am J Physiol Lung Cell Mol Physiol 2015 Jul 8;309(2):L139-46. Epub 2015 May 8.

Department of Respiratory Medicine, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China; and.

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http://dx.doi.org/10.1152/ajplung.00292.2014DOI Listing
July 2015

Clinical and prognostic heterogeneity of C and D GOLD groups.

Eur Respir J 2015 Jul;46(1):250-4

Dept of Respiratory Medicine, Brigham and Women's Hospital, Boston, MA, USA.

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http://dx.doi.org/10.1183/09031936.00012215DOI Listing
July 2015

One-year change in health status and subsequent outcomes in COPD.

Thorax 2015 May 17;70(5):420-5. Epub 2015 Mar 17.

Department of Research & Education, CIRO+, Centre of Expertise for Chronic Organ Failure, Horn, The Netherlands Faculty of Medicine and Life Sciences, REVAL-Rehabilitation Research Center, BIOMED-Biomedical Research Institute, Hasselt University, Diepenbeek, Belgium.

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http://thorax.bmj.com/content/early/2015/03/17/thoraxjnl-201
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http://dx.doi.org/10.1136/thoraxjnl-2014-205697DOI Listing
May 2015

Genome-wide mRNA expression profiling in vastus lateralis of COPD patients with low and normal fat free mass index and healthy controls.

Respir Res 2015 Jan 8;16. Epub 2015 Jan 8.

ELEGI Colt Laboratory, Centre for Inflammation Research, The Queen's Medical Research Institute, University of Edinburgh, 47 Little France Crescent, Edinburgh, Scotland, EH16 4TJ, UK.

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http://dx.doi.org/10.1186/s12931-014-0139-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4333166PMC
January 2015

Twenty-Ninth Transatlantic Airway Conference. Innate and adaptive immune responses in airway disease. Purpose of the conference.

Ann Am Thorac Soc 2014 Dec;11 Suppl 5:S233

1 University of Edinburgh Edinburgh, Scotland.

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http://dx.doi.org/10.1513/AnnalsATS.11supplement_5S233DOI Listing
December 2014

Ageing and the border between health and disease.

Eur Respir J 2014 Nov 16;44(5):1332-52. Epub 2014 Oct 16.

ELEGI Colt Research Laboratories, MRC Centre for Inflammation Research, University of Edinburgh, Edinburgh, UK.

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http://erj.ersjournals.com/cgi/doi/10.1183/09031936.00134014
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http://dx.doi.org/10.1183/09031936.00134014DOI Listing
November 2014

Evaluating the role of inflammation in chronic airways disease: the ERICA study.

COPD 2014 Sep 15;11(5):552-9. Epub 2014 May 15.

1NIHR Respiratory Biomedical Research Unit, Royal Brompton & Harefield NHS Foundation Trust and Imperial College, London, UK.

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http://dx.doi.org/10.3109/15412555.2014.898031DOI Listing
September 2014

Lessons from ECLIPSE: a review of COPD biomarkers.

Thorax 2014 Jul 5;69(7):666-72. Epub 2013 Dec 5.

Fundació Investigació Sanitària Illes Balears (FISIB), Ciber Enfermedades Respiratorias (CIBERES), Barcelona, Catalunya, Spain Thorax Institute, Hospital Clinic, IDIBAPS, Univ. Barcelona, Barcelona, Spain.

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http://dx.doi.org/10.1136/thoraxjnl-2013-204778DOI Listing
July 2014

The Association Between Dietary Intake and Phenotypical Characteristics of COPD in the ECLIPSE Cohort.

Chronic Obstr Pulm Dis 2014 May 6;1(1):115-124. Epub 2014 May 6.

Division of Pulmonary, Critical Care, Allergy and Sleep Medicine, Department of Internal Medicine, University of Nebraska Medical Center, Omaha.

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http://dx.doi.org/10.15326/jcopdf.1.1.2014.0113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5559148PMC
May 2014

Surface functionalization affects the zeta potential, coronal stability and membranolytic activity of polymeric nanoparticles.

Nanotoxicology 2014 Mar 28;8(2):202-11. Epub 2013 May 28.

ELEGI/Colt Laboratory, Centre for Inflammation Research, University of Edinburgh , Edinburgh , UK.

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http://dx.doi.org/10.3109/17435390.2013.773465DOI Listing
March 2014

Comorbidities and systemic effects of chronic obstructive pulmonary disease.

Clin Chest Med 2014 Mar;35(1):101-30

ELEGI and COLT Laboratories, Queen's Medical Research Institute, 47 Little France Crescent, EH16 4TJ Edinburgh, UK.

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http://dx.doi.org/10.1016/j.ccm.2013.10.007DOI Listing
March 2014

Endothelial progenitor cells in patients with chronic obstructive pulmonary disease.

Am J Physiol Lung Cell Mol Physiol 2013 Dec 18;305(12):L964-9. Epub 2013 Oct 18.

BHF/Univ. Centre for Cardiovascular Science, The Univ. of Edinburgh, Scottish Centre for Regenerative Medicine, Little France Crescent, Edinburgh EH16 4UU, UK.

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http://www.physiology.org/doi/10.1152/ajplung.00183.2013
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http://dx.doi.org/10.1152/ajplung.00183.2013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3882533PMC
December 2013

Purpose of the conference.

Ann Am Thorac Soc 2013 Dec;10 Suppl:S107

1 University of Edinburgh, Edinburgh, Scotland.

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http://dx.doi.org/10.1513/AnnalsATS.201307-233AWDOI Listing
December 2013

Sputum matrix metalloproteinase-9 is associated with the degree of emphysema on computed tomography in COPD.

Transl Respir Med 2013 Dec 6;1(1):11. Epub 2013 Jun 6.

Immunology, Institute of Infection, Immunity & Inflammation, University of Glasgow and Gartnavel General Hospital, Glasgow, Scotland, G12 OYN, UK.

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http://dx.doi.org/10.1186/2213-0802-1-11DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6733425PMC
December 2013

The search for distinct and clinically useful phenotypes in chronic obstructive pulmonary disease.

Am J Respir Crit Care Med 2013 Nov;188(9):1045-6

1 Department of Respiratory Medicine, Gentofte Hospital Copenhagen University Hellerup, Denmark.

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http://dx.doi.org/10.1164/rccm.201309-1649EDDOI Listing
November 2013

Vitamin D, vitamin D binding protein, lung function and structure in COPD.

Respir Med 2013 Oct 1;107(10):1578-88. Epub 2013 Jul 1.

Division of Internal Medicine, University of Nebraska Medical Center, Omaha, NE 68198-5300, United States.

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http://dx.doi.org/10.1016/j.rmed.2013.05.010DOI Listing
October 2013

Chronic cough and sputum production are associated with worse clinical outcomes in stable asthma.

Respir Med 2013 Oct 6;107(10):1501-8. Epub 2013 Aug 6.

Institute of Infection, Immunity & Inflammation, University of Glasgow, Glasgow, UK. Electronic address:

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http://dx.doi.org/10.1016/j.rmed.2013.07.017DOI Listing
October 2013

Predictive value of in vitro assays depends on the mechanism of toxicity of metal oxide nanoparticles.

Part Fibre Toxicol 2013 Oct 25;10(1):55. Epub 2013 Oct 25.

ELEGI/Colt Laboratory, Centre for Inflammation Research, University of Edinburgh, 47 Little France Crescent, Edinburgh EH16 4TJ, UK.

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http://dx.doi.org/10.1186/1743-8977-10-55DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4016420PMC
October 2013

Characteristics, stability and outcomes of the 2011 GOLD COPD groups in the ECLIPSE cohort.

Eur Respir J 2013 Sep 13;42(3):636-46. Epub 2013 Jun 13.

Hospital Clinic, IDIBAPS, Universitat de Barcelona and CIBER Enfermedades Respiratorias, FISIB, Mallorca, Spain.

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http://dx.doi.org/10.1183/09031936.00195212DOI Listing
September 2013

Response.

Chest 2013 Sep;144(3):1081-1082

University of Edinburgh, MRC Centre for Inflammation Research, The Edinburgh University, Edinburgh, Scotland.

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http://dx.doi.org/10.1378/chest.13-1352DOI Listing
September 2013

Efficacy and safety of the oral p38 inhibitor PH-797804 in chronic obstructive pulmonary disease: a randomised clinical trial.

Thorax 2013 Aug 28;68(8):738-45. Epub 2013 Mar 28.

Queen's Medical Research Institute, University of Edinburgh, Edinburgh, UK.

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http://dx.doi.org/10.1136/thoraxjnl-2012-202744DOI Listing
August 2013

The COPD control panel: towards personalised medicine in COPD.

Thorax 2013 Jul 1;68(7):687-90. Epub 2012 Nov 1.

Hospital Clinic, IDIBAPS, Thorax Institute, University of Barcelona, Barcelona, Spain.

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http://dx.doi.org/10.1136/thoraxjnl-2012-202772DOI Listing
July 2013

Systemic inflammatory biomarkers and co-morbidities of chronic obstructive pulmonary disease.

Authors:
William MacNee

Ann Med 2013 May 30;45(3):291-300. Epub 2012 Oct 30.

ELEGI, Colt Research Laboratories, MRC/UoE Centre for Inflammation Research, Queen's Medical Research Institute, 47 Little France Crescent, Edinburgh EH 16 4TJ, UK.

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http://dx.doi.org/10.3109/07853890.2012.732703DOI Listing
May 2013

Cardiovascular disease in COPD: mechanisms.

Chest 2013 Mar;143(3):798-807

MRC Centre for Inflammation Research, The Edinburgh University, Edinburgh, Scotland. Electronic address:

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http://dx.doi.org/10.1378/chest.12-0938DOI Listing
March 2013

Bone attenuation on routine chest CT correlates with bone mineral density on DXA in patients with COPD.

J Bone Miner Res 2012 Nov;27(11):2338-43

Department of Respiratory Medicine, Catharina Hospital Eindhoven, Eindhoven, The Netherlands.

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http://dx.doi.org/10.1002/jbmr.1678DOI Listing
November 2012

Neuromuscular electrical stimulation prevents muscle function deterioration in exacerbated COPD: a pilot study.

Respir Med 2012 Oct 20;106(10):1429-34. Epub 2012 Jun 20.

ELEGI Colt Laboratory, Centre for Inflammation Research, The Queen's Medical Research Institute, University of Edinburgh, 47 Little France Crescent, Edinburgh EH16 4TJ, Scotland, UK.

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http://dx.doi.org/10.1016/j.rmed.2012.05.005DOI Listing
October 2012

Persistent systemic inflammation is associated with poor clinical outcomes in COPD: a novel phenotype.

PLoS One 2012 18;7(5):e37483. Epub 2012 May 18.

Thorax Institute, Hospital Clinic, Institut d'investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), University of Barcelona and Centro de investigación en red de enfermedades respiratorias (CIBERES), Barcelona, Spain.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0037483PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3356313PMC
September 2012

Abnormal lung aging in chronic obstructive pulmonary disease and idiopathic pulmonary fibrosis.

Am J Respir Crit Care Med 2012 Aug 10;186(4):306-13. Epub 2012 May 10.

Fundación Investigación Sanitaria Illes Balears, Centro de Investigación Biomédica en Red Enfermedades Respiratorias (CIBERES), Palma de Mallorca, and Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain.

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http://dx.doi.org/10.1164/rccm.201202-0282PPDOI Listing
August 2012

The threshold length for fiber-induced acute pleural inflammation: shedding light on the early events in asbestos-induced mesothelioma.

Toxicol Sci 2012 Aug 12;128(2):461-70. Epub 2012 May 12.

MRC/University of Edinburgh, Centre for Inflammation Research, Queen's Medical Research Institute,47 Little France Crescent, Edinburgh EH16 4TJ, United Kingdom.

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http://dx.doi.org/10.1093/toxsci/kfs171DOI Listing
August 2012

Systemic elastin degradation in chronic obstructive pulmonary disease.

Thorax 2012 Jul 28;67(7):606-12. Epub 2012 Feb 28.

ELEGI Colt Laboratory, Queen's Medical Research Institute, The University of Edinburgh, 47 Little France Crescent, Edinburgh EH16 4TJ, UK.

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http://dx.doi.org/10.1136/thoraxjnl-2011-200949DOI Listing
July 2012

Antioxidant pharmacological therapies for COPD.

Curr Opin Pharmacol 2012 Jun 18;12(3):256-65. Epub 2012 Feb 18.

Department of Environmental Medicine, Lung Biology and Disease Program, University of Rochester Medical Center, Rochester, NY, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S14714892120001
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http://dx.doi.org/10.1016/j.coph.2012.01.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3768007PMC
June 2012

Diagnosis of myocardial infarction following hospitalisation for exacerbation of COPD.

Eur Respir J 2012 May 9;39(5):1097-103. Epub 2012 Feb 9.

ELEGI/COLT Laboratories, Queens Medial Research Institute, University of Edinburgh, Edinburgh, UK.

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http://dx.doi.org/10.1183/09031936.00124811DOI Listing
May 2012