William M Grady

William M Grady

UNVERIFIED PROFILE

Are you William M Grady?   Register this Author

Register author
William M Grady

William M Grady

Publications by authors named "William M Grady"

Are you William M Grady?   Register this Author

100Publications

1913Reads

33Profile Views

Senescence-associated tissue microenvironment promotes colon cancer formation through the secretory factor GDF15.

Aging Cell 2019 Aug 6:e13013. Epub 2019 Aug 6.

Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/acel.13013DOI Listing
August 2019

Novel Barrett's esophagus screening assays based on swallowable devices: will they change the game?

Transl Gastroenterol Hepatol 2019 19;4:25. Epub 2019 Apr 19.

Department of Medicine, University of Washington School of Medicine, Seattle, WA, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.21037/tgh.2019.04.01DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6509432PMC
April 2019

The ColoCare Study: A Paradigm of Transdisciplinary Science in Colorectal Cancer Outcomes.

Cancer Epidemiol Biomarkers Prev 2019 Mar 6;28(3):591-601. Epub 2018 Dec 6.

Department of General, Visceral and Transplantation Surgery, University Hospital of Heidelberg, Heidelberg, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/1055-9965.EPI-18-0773DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6420345PMC
March 2019

DNA Methylation Analysis Using Droplet Digital PCR.

Methods Mol Biol 2018 ;1768:363-383

Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/978-1-4939-7778-9_21DOI Listing
February 2019

Novel Common Genetic Susceptibility Loci for Colorectal Cancer.

Authors:
Stephanie L Schmit Christopher K Edlund Fredrick R Schumacher Jian Gong Tabitha A Harrison Jeroen R Huyghe Chenxu Qu Marilena Melas David J Van Den Berg Hansong Wang Stephanie Tring Sarah J Plummer Demetrius Albanes M Henar Alonso Christopher I Amos Kristen Anton Aaron K Aragaki Volker Arndt Elizabeth L Barry Sonja I Berndt Stéphane Bezieau Stephanie Bien Amanda Bloomer Juergen Boehm Marie-Christine Boutron-Ruault Hermann Brenner Stefanie Brezina Daniel D Buchanan Katja Butterbach Bette J Caan Peter T Campbell Christopher S Carlson Jose E Castelao Andrew T Chan Jenny Chang-Claude Stephen J Chanock Iona Cheng Ya-Wen Cheng Lee Soo Chin James M Church Timothy Church Gerhard A Coetzee Michelle Cotterchio Marcia Cruz Correa Keith R Curtis David Duggan Douglas F Easton Dallas English Edith J M Feskens Rocky Fischer Liesel M FitzGerald Barbara K Fortini Lars G Fritsche Charles S Fuchs Manuela Gago-Dominguez Manish Gala Steven J Gallinger W James Gauderman Graham G Giles Edward L Giovannucci Stephanie M Gogarten Clicerio Gonzalez-Villalpando Elena M Gonzalez-Villalpando William M Grady Joel K Greenson Andrea Gsur Marc Gunter Christopher A Haiman Jochen Hampe Sophia Harlid John F Harju Richard B Hayes Philipp Hofer Michael Hoffmeister John L Hopper Shu-Chen Huang Jose Maria Huerta Thomas J Hudson David J Hunter Gregory E Idos Motoki Iwasaki Rebecca D Jackson Eric J Jacobs Sun Ha Jee Mark A Jenkins Wei-Hua Jia Shuo Jiao Amit D Joshi Laurence N Kolonel Suminori Kono Charles Kooperberg Vittorio Krogh Tilman Kuehn Sébastien Küry Andrea LaCroix Cecelia A Laurie Flavio Lejbkowicz Mathieu Lemire Heinz-Josef Lenz David Levine Christopher I Li Li Li Wolfgang Lieb Yi Lin Noralane M Lindor Yun-Ru Liu Fotios Loupakis Yingchang Lu Frank Luh Jing Ma Christoph Mancao Frank J Manion Sanford D Markowitz Vicente Martin Koichi Matsuda Keitaro Matsuo Kevin J McDonnell Caroline E McNeil Roger Milne Antonio J Molina Bhramar Mukherjee Neil Murphy Polly A Newcomb Kenneth Offit Hanane Omichessan Domenico Palli Jesus P Paredes Cotoré Julyann Pérez-Mayoral Paul D Pharoah John D Potter Conghui Qu Leon Raskin Gad Rennert Hedy S Rennert Bridget M Riggs Clemens Schafmayer Robert E Schoen Thomas A Sellers Daniela Seminara Gianluca Severi Wei Shi David Shibata Xiao-Ou Shu Erin M Siegel Martha L Slattery Melissa Southey Zsofia K Stadler Mariana C Stern Sebastian Stintzing Darin Taverna Stephen N Thibodeau Duncan C Thomas Antonia Trichopoulou Shoichiro Tsugane Cornelia M Ulrich Franzel J B van Duijnhoven Bethany van Guelpan Joseph Vijai Jarmo Virtamo Stephanie J Weinstein Emily White Aung Ko Win Alicja Wolk Michael Woods Anna H Wu Kana Wu Yong-Bing Xiang Yun Yen Brent W Zanke Yi-Xin Zeng Ben Zhang Niha Zubair Sun-Seog Kweon Jane C Figueiredo Wei Zheng Loic Le Marchand Annika Lindblom Victor Moreno Ulrike Peters Graham Casey Li Hsu David V Conti Stephen B Gruber

J Natl Cancer Inst 2019 Feb;111(2):146-157

Department of Preventive Medicine, USC Norris Comprehensive Cancer Center.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/jnci/djy099DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6555904PMC
February 2019

Discovery of common and rare genetic risk variants for colorectal cancer.

Authors:
Jeroen R Huyghe Stephanie A Bien Tabitha A Harrison Hyun Min Kang Sai Chen Stephanie L Schmit David V Conti Conghui Qu Jihyoun Jeon Christopher K Edlund Peyton Greenside Michael Wainberg Fredrick R Schumacher Joshua D Smith David M Levine Sarah C Nelson Nasa A Sinnott-Armstrong Demetrius Albanes M Henar Alonso Kristin Anderson Coral Arnau-Collell Volker Arndt Christina Bamia Barbara L Banbury John A Baron Sonja I Berndt Stéphane Bézieau D Timothy Bishop Juergen Boehm Heiner Boeing Hermann Brenner Stefanie Brezina Stephan Buch Daniel D Buchanan Andrea Burnett-Hartman Katja Butterbach Bette J Caan Peter T Campbell Christopher S Carlson Sergi Castellví-Bel Andrew T Chan Jenny Chang-Claude Stephen J Chanock Maria-Dolores Chirlaque Sang Hee Cho Charles M Connolly Amanda J Cross Katarina Cuk Keith R Curtis Albert de la Chapelle Kimberly F Doheny David Duggan Douglas F Easton Sjoerd G Elias Faye Elliott Dallas R English Edith J M Feskens Jane C Figueiredo Rocky Fischer Liesel M FitzGerald David Forman Manish Gala Steven Gallinger W James Gauderman Graham G Giles Elizabeth Gillanders Jian Gong Phyllis J Goodman William M Grady John S Grove Andrea Gsur Marc J Gunter Robert W Haile Jochen Hampe Heather Hampel Sophia Harlid Richard B Hayes Philipp Hofer Michael Hoffmeister John L Hopper Wan-Ling Hsu Wen-Yi Huang Thomas J Hudson David J Hunter Gemma Ibañez-Sanz Gregory E Idos Roxann Ingersoll Rebecca D Jackson Eric J Jacobs Mark A Jenkins Amit D Joshi Corinne E Joshu Temitope O Keku Timothy J Key Hyeong Rok Kim Emiko Kobayashi Laurence N Kolonel Charles Kooperberg Tilman Kühn Sébastien Küry Sun-Seog Kweon Susanna C Larsson Cecelia A Laurie Loic Le Marchand Suzanne M Leal Soo Chin Lee Flavio Lejbkowicz Mathieu Lemire Christopher I Li Li Li Wolfgang Lieb Yi Lin Annika Lindblom Noralane M Lindor Hua Ling Tin L Louie Satu Männistö Sanford D Markowitz Vicente Martín Giovanna Masala Caroline E McNeil Marilena Melas Roger L Milne Lorena Moreno Neil Murphy Robin Myte Alessio Naccarati Polly A Newcomb Kenneth Offit Shuji Ogino N Charlotte Onland-Moret Barbara Pardini Patrick S Parfrey Rachel Pearlman Vittorio Perduca Paul D P Pharoah Mila Pinchev Elizabeth A Platz Ross L Prentice Elizabeth Pugh Leon Raskin Gad Rennert Hedy S Rennert Elio Riboli Miguel Rodríguez-Barranco Jane Romm Lori C Sakoda Clemens Schafmayer Robert E Schoen Daniela Seminara Mitul Shah Tameka Shelford Min-Ho Shin Katerina Shulman Sabina Sieri Martha L Slattery Melissa C Southey Zsofia K Stadler Christa Stegmaier Yu-Ru Su Catherine M Tangen Stephen N Thibodeau Duncan C Thomas Sushma S Thomas Amanda E Toland Antonia Trichopoulou Cornelia M Ulrich David J Van Den Berg Franzel J B van Duijnhoven Bethany Van Guelpen Henk van Kranen Joseph Vijai Kala Visvanathan Pavel Vodicka Ludmila Vodickova Veronika Vymetalkova Korbinian Weigl Stephanie J Weinstein Emily White Aung Ko Win C Roland Wolf Alicja Wolk Michael O Woods Anna H Wu Syed H Zaidi Brent W Zanke Qing Zhang Wei Zheng Peter C Scacheri John D Potter Michael C Bassik Anshul Kundaje Graham Casey Victor Moreno Goncalo R Abecasis Deborah A Nickerson Stephen B Gruber Li Hsu Ulrike Peters

Nat Genet 2019 01 3;51(1):76-87. Epub 2018 Dec 3.

Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.

View Article

Download full-text PDF

Source
http://www.nature.com/articles/s41588-018-0286-6
Publisher Site
http://dx.doi.org/10.1038/s41588-018-0286-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6358437PMC
January 2019

Molecular Evolution of Metaplasia to Adenocarcinoma in the Esophagus.

Dig Dis Sci 2018 08;63(8):2059-2069

Clinical Research Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N. D4-100, Seattle, WA, 98109, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s10620-018-5090-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6597264PMC
August 2018

New insights into the earliest stages of colorectal tumorigenesis.

Expert Rev Gastroenterol Hepatol 2017 Aug 26;11(8):723-729. Epub 2017 May 26.

f Department of Radiology , University of Wisconsin School of Medicine and Public Health , Madison , WI , USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/17474124.2017.1330150DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5859121PMC
August 2017

Global DNA methylation patterns in Barrett's esophagus, dysplastic Barrett's, and esophageal adenocarcinoma are associated with BMI, gender, and tobacco use.

Clin Epigenetics 2016 27;8:111. Epub 2016 Oct 27.

Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 USA ; Department of Medicine, University of Washington School of Medicine, Seattle, WA 98195 USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s13148-016-0273-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5082363PMC
April 2017

Use of NCCN Guidelines, Other Guidelines, and Biomarkers for Colorectal Cancer Screening.

J Natl Compr Canc Netw 2016 11;14(11):1479-1485

From Cooperative Studies Program Epidemiology Center-Durham, Durham VA Medical Center, and Division of Medical Oncology, Duke University Medical Center, Durham, North Carolina; Clinical Research Division, Fred Hutchison Cancer Research Center, and Department of Medicine, University of Washington, Seattle, Washington; and Center for Health Services Research in Primary Care, Durham VA Medical Center, and Division of General Internal Medicine, Duke University Medical Center, Durham, North Carolina.

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5117951PMC
November 2016

Single cell lineage tracing reveals a role for TgfβR2 in intestinal stem cell dynamics and differentiation.

Proc Natl Acad Sci U S A 2016 10 10;113(43):12192-12197. Epub 2016 Oct 10.

Department of Molecular and Medical Genetics, Oregon Health and Science University, Portland, OR 97239.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1073/pnas.1611980113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5087053PMC
October 2016

Epigenetic silencing of TPM2 contributes to colorectal cancer progression upon RhoA activation.

Tumour Biol 2016 Sep 23;37(9):12477-12483. Epub 2016 Jun 23.

Department of Colorectal Surgery, the Sixth Affilated Hospital of Sun Yat-Sen University, Guangzhou, 56055, China.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s13277-016-5103-1DOI Listing
September 2016

Linkage and related analyses of Barrett's esophagus and its associated adenocarcinomas.

Mol Genet Genomic Med 2016 Jul 14;4(4):407-19. Epub 2016 Mar 14.

Case Comprehensive Cancer CenterCase Western Reserve University School of MedicineClevelandOhio; Division of Gastroenterology and HepatologyUniversity Hospitals Case Medical CenterCase Western Reserve University School of MedicineClevelandOhio.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/mgg3.211DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4947860PMC
July 2016

Predicting Barrett's Esophagus in Families: An Esophagus Translational Research Network (BETRNet) Model Fitting Clinical Data to a Familial Paradigm.

Cancer Epidemiol Biomarkers Prev 2016 05 29;25(5):727-35. Epub 2016 Feb 29.

Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Cleveland, Ohio. Division of Gastroenterology and Hepatology, University Hospitals Case Medical Center, Case Western Reserve University School of Medicine, Cleveland, Ohio.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/1055-9965.EPI-15-0832DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4873373PMC
May 2016

A Molecular Clock Infers Heterogeneous Tissue Age Among Patients with Barrett's Esophagus.

PLoS Comput Biol 2016 05 11;12(5):e1004919. Epub 2016 May 11.

Program in Computational Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1371/journal.pcbi.1004919DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4864310PMC
May 2016

Methylated B3GAT2 and ZNF793 Are Potential Detection Biomarkers for Barrett's Esophagus.

Cancer Epidemiol Biomarkers Prev 2015 Dec 6;24(12):1890-7. Epub 2015 Nov 6.

Division of Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, Washington. Department of Medicine, University of Washington School of Medicine, Seattle, Washington.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/1055-9965.EPI-15-0370DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4670566PMC
December 2015

Colorectal cancer.

Nat Rev Dis Primers 2015 11 5;1:15065. Epub 2015 Nov 5.

Department of Surgical Oncology and Vascular Surgery, University of Tokyo and the University of Tokyo Hospital, Tokyo, Japan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nrdp.2015.65DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4874655PMC
November 2015

Epigenetic Alterations in Colorectal Cancer: Emerging Biomarkers.

Gastroenterology 2015 Oct 26;149(5):1204-1225.e12. Epub 2015 Jul 26.

Gastrointestinal Cancer Research Laboratory, Division of Gastroenterology, Department of Internal Medicine, Charles A. Sammons Cancer Center and Baylor Research Institute, Baylor University Medical Center, Dallas, Texas. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1053/j.gastro.2015.07.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4589488PMC
October 2015

Molecular markers for colorectal cancer screening.

Gut 2015 Sep 20;64(9):1485-94. Epub 2015 May 20.

Department of Medicine, University of Washington School of Medicine, Seattle, Washington, USA Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/gutjnl-2014-308075DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4765995PMC
September 2015

Polymerase Slippage Restoration of Frameshifted TGFBR2 in Colorectal Cancer: A Novel Paradigm.

Authors:
William M Grady

Gastroenterology 2015 Jun 25;148(7):1276-9. Epub 2015 Apr 25.

Fred Hutchinson Cancer Research Center, University of Washington Medical School, Seattle, Washington. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1053/j.gastro.2015.04.023DOI Listing
June 2015

Genetic and Epigenetic Alterations in Barrett's Esophagus and Esophageal Adenocarcinoma.

Gastroenterol Clin North Am 2015 Jun 1;44(2):473-89. Epub 2015 Apr 1.

Department of Medical Oncology, Dana-Farber Cancer Institute, 450 Brookline Avenue, Boston, MA 02215, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.gtc.2015.02.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4449457PMC
June 2015

The molecular pathogenesis of colorectal cancer and its potential application to colorectal cancer screening.

Dig Dis Sci 2015 Mar 10;60(3):762-72. Epub 2014 Dec 10.

Clinical Research Division, Fred Hutchison Cancer Research Center, 1100 Fairview Avenue N., D4-100, Seattle, WA, 98109, USA,

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s10620-014-3444-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4779895PMC
March 2015

Actionable exomic incidental findings in 6503 participants: challenges of variant classification.

Genome Res 2015 Mar 30;25(3):305-15. Epub 2015 Jan 30.

Department of Medicine, Division of Medical Genetics, University of Washington, Seattle, Washington 98195, USA; Department of Genome Sciences, University of Washington, Seattle, Washington 98195, USA;

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1101/gr.183483.114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4352885PMC
March 2015

Molecular markers predictive of chemotherapy response in colorectal cancer.

Curr Gastroenterol Rep 2015 Feb;17(2):431

University of Washington, 825 Eastlake Ave E., G4-830, Seattle, WA, 98109, USA,

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s11894-015-0431-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4475027PMC
February 2015

Differences in DNA methylation signatures reveal multiple pathways of progression from adenoma to colorectal cancer.

Gastroenterology 2014 Aug 30;147(2):418-29.e8. Epub 2014 Apr 30.

Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington; Department of Medicine, University of Washington School of Medicine, Seattle, Washington. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1053/j.gastro.2014.04.039DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4107146PMC
August 2014

Increased dietary vitamin D suppresses MAPK signaling, colitis, and colon cancer.

Cancer Res 2014 Aug 17;74(16):4398-408. Epub 2014 Jun 17.

Department of Comparative Medicine, University of Washington, Seattle, Washington.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/0008-5472.CAN-13-2820DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4134774PMC
August 2014

Patterns of DNA methylation in the normal colon vary by anatomical location, gender, and age.

Epigenetics 2014 Apr 10;9(4):492-502. Epub 2014 Jan 10.

Division of Clinical Research; Fred Hutchinson Cancer Research Center; Seattle, WA USA; Department of Medicine; University of Washington School of Medicine; Seattle, WA USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4161/epi.27650DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4121360PMC
April 2014

Field cancerization in the colon: a role for aberrant DNA methylation?

Gastroenterol Rep (Oxf) 2014 Feb 13;2(1):16-20. Epub 2014 Jan 13.

Department of Colorectal Surgery, The Sixth Affiliated Hospital, Sun Yat-Sen University, Guangzhou, P.R. China, Gastrointestinal Institute, Sun Yat-Sen University, Guangzhou, P.R. China, Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA and Department of Medicine, University of Washington School of Medicine, Seattle, WA, USA.

View Article

Download full-text PDF

Source
https://academic.oup.com/gastro/article-lookup/doi/10.1093/g
Publisher Site
http://dx.doi.org/10.1093/gastro/got039DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3920999PMC
February 2014

Epigenetic biomarkers in esophageal cancer.

Cancer Lett 2014 Jan 7;342(2):193-9. Epub 2012 Mar 7.

Division of Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, WA, United States; Department of Medicine, University of Washington School of Medicine, Seattle, WA, United States; Research and Development Service, VA Puget Sound Health Care System, Seattle, WA, United States. Electronic address:

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S03043835120015
Publisher Site
http://dx.doi.org/10.1016/j.canlet.2012.02.036DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3395756PMC
January 2014

NTRK3 is a potential tumor suppressor gene commonly inactivated by epigenetic mechanisms in colorectal cancer.

PLoS Genet 2013 11;9(7):e1003552. Epub 2013 Jul 11.

Department of Colorectal Surgery, The Sixth Affiliated Hospital, Sun Yat-Sen University, Guangzhou, PR China.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1371/journal.pgen.1003552DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3708790PMC
January 2014

Barrett's oesophagus: epidemiology, cancer risk and implications for management.

Gut 2014 Jan 3;63(1):191-202. Epub 2013 Oct 3.

Department of Gastroenterology and Hepatology, Erasmus MC University Medical Center Rotterdam, , Rotterdam, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/gutjnl-2013-305490DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6597262PMC
January 2014

Molecular alterations and biomarkers in colorectal cancer.

Toxicol Pathol 2014 Jan 31;42(1):124-39. Epub 2013 Oct 31.

1Clinical Research Division, Fred Hutchison Cancer Research Center, Seattle, Washington, USA.

View Article

Download full-text PDF

Source
http://journals.sagepub.com/doi/10.1177/0192623313505155
Publisher Site
http://dx.doi.org/10.1177/0192623313505155DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3947043PMC
January 2014

A physical sciences network characterization of non-tumorigenic and metastatic cells.

Authors:
David B Agus Jenolyn F Alexander Wadih Arap Shashanka Ashili Joseph E Aslan Robert H Austin Vadim Backman Kelly J Bethel Richard Bonneau Wei-Chiang Chen Chira Chen-Tanyolac Nathan C Choi Steven A Curley Matthew Dallas Dhwanil Damania Paul C W Davies Paolo Decuzzi Laura Dickinson Luis Estevez-Salmeron Veronica Estrella Mauro Ferrari Claudia Fischbach Jasmine Foo Stephanie I Fraley Christian Frantz Alexander Fuhrmann Philippe Gascard Robert A Gatenby Yue Geng Sharon Gerecht Robert J Gillies Biana Godin William M Grady Alex Greenfield Courtney Hemphill Barbara L Hempstead Abigail Hielscher W Daniel Hillis Eric C Holland Arig Ibrahim-Hashim Tyler Jacks Roger H Johnson Ahyoung Joo Jonathan E Katz Laimonas Kelbauskas Carl Kesselman Michael R King Konstantinos Konstantopoulos Casey M Kraning-Rush Peter Kuhn Kevin Kung Brian Kwee Johnathon N Lakins Guillaume Lambert David Liao Jonathan D Licht Jan T Liphardt Liyu Liu Mark C Lloyd Anna Lyubimova Parag Mallick John Marko Owen J T McCarty Deirdre R Meldrum Franziska Michor Shannon M Mumenthaler Vivek Nandakumar Thomas V O'Halloran Steve Oh Renata Pasqualini Matthew J Paszek Kevin G Philips Christopher S Poultney Kuldeepsinh Rana Cynthia A Reinhart-King Robert Ros Gregg L Semenza Patti Senechal Michael L Shuler Srimeenakshi Srinivasan Jack R Staunton Yolanda Stypula Hariharan Subramanian Thea D Tlsty Garth W Tormoen Yiider Tseng Alexander van Oudenaarden Scott S Verbridge Jenny C Wan Valerie M Weaver Jonathan Widom Christine Will Denis Wirtz Jonathan Wojtkowiak Pei-Hsun Wu

Sci Rep 2013 ;3:1449

Center for Applied Molecular Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/srep01449DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3636513PMC
October 2013

Altered RECQ Helicase Expression in Sporadic Primary Colorectal Cancers.

Transl Oncol 2013 Aug 1;6(4):458-69. Epub 2013 Aug 1.

Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA ; Department of Surgery, University of Washington Medical School, Seattle, WA ; Department of Surgery, University of Nebraska Medical School, Omaha, NE.

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3730021PMC
http://dx.doi.org/10.1593/tlo.13238DOI Listing
August 2013

Context is everything for dependence receptors in colorectal cancer.

Authors:
William M Grady

Proc Natl Acad Sci U S A 2013 Feb 8;110(8):2697-8. Epub 2013 Feb 8.

Clinical Research Division, Fred Hutchinson Cancer Research Center, Department of Medicine, University of Washington Medical School, Seattle, WA 98109, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1073/pnas.1300758110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3581887PMC
February 2013

Therapeutic targeting of the phosphatidylinositol 3-kinase signaling pathway: novel targeted therapies and advances in the treatment of colorectal cancer.

Therap Adv Gastroenterol 2012 Sep;5(5):319-37

Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/1756283X12448456DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3437536PMC
September 2012

Association of insulin and insulin-like growth factors with Barrett's oesophagus.

Gut 2012 May 19;61(5):665-72. Epub 2011 Sep 19.

Division of Gastroenterology and Liver Disease, University Hospitals Case Medical Center, Cleveland, Ohio, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/gutjnl-2011-300641DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3669672PMC
May 2012

Aberrantly methylated PKP1 in the progression of Barrett's esophagus to esophageal adenocarcinoma.

Genes Chromosomes Cancer 2012 Apr 14;51(4):384-93. Epub 2011 Dec 14.

Division of Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/gcc.21923DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3292431PMC
April 2012

Variation in age at cancer diagnosis in familial versus nonfamilial Barrett's esophagus.

Cancer Epidemiol Biomarkers Prev 2012 Feb 16;21(2):376-83. Epub 2011 Dec 16.

Division of Gastroenterology, University Hospitals-Case Medical Center, 11100 Euclid Avenue, Cleveland, OH 44106, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/1055-9965.EPI-11-0927DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3275661PMC
February 2012

Transforming growth factor-beta signaling promotes hepatocarcinogenesis induced by p53 loss.

Hepatology 2012 Jan 6;55(1):121-31. Epub 2011 Dec 6.

Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109-1024, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/hep.24653DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3237853PMC
January 2012

Epigenetics and colorectal cancer.

Nat Rev Gastroenterol Hepatol 2011 Oct 18;8(12):686-700. Epub 2011 Oct 18.

Department of Surgery, University of Washington, Box 356410, 1959 NE Pacific Street, Seattle, WA 98195, USA.

View Article

Download full-text PDF

Source
http://www.nature.com/articles/nrgastro.2011.173
Publisher Site
http://dx.doi.org/10.1038/nrgastro.2011.173DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3391545PMC
October 2011

Colorectal cancer molecular biology moves into clinical practice.

Gut 2011 Jan 4;60(1):116-29. Epub 2010 Oct 4.

Department of Laboratory Medicine, University of Washington, Washington, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/gut.2009.206250DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3006043PMC
January 2011

Linking epidemiology to epigenomics--where are we today?

Cancer Prev Res (Phila) 2010 Dec;3(12):1505-8

National Center for Tumor Diseases Heidelberg (NCT), Division of Preventive Oncology, Im Neuenheimer Feld 460, D-69120 Heidelberg, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/1940-6207.CAPR-10-0298DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3048787PMC
December 2010

Insights into the role of DNA methylation in disease through the use of mouse models.

Dis Model Mech 2010 May-Jun;3(5-6):290-7

Basic Science Division, University of Washington Medical School, 1959 Northeast Pacific Street, Seattle, WA 98195, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1242/dmm.004812DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2860849PMC
September 2010

The next thing in prognostic molecular markers: microRNA signatures of cancer.

Gut 2010 Jun;59(6):706-8

Division of Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/gut.2009.200022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3377960PMC
June 2010

A segregation analysis of Barrett's esophagus and associated adenocarcinomas.

Cancer Epidemiol Biomarkers Prev 2010 Mar 3;19(3):666-74. Epub 2010 Mar 3.

Department of Epidemiology and Biostatistics, Case Western Reserve University, 2103 Cornell Road, Cleveland, OH 44106, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/1055-9965.EPI-09-1136DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2838211PMC
March 2010

Assessment of familiality, obesity, and other risk factors for early age of cancer diagnosis in adenocarcinomas of the esophagus and gastroesophageal junction.

Am J Gastroenterol 2009 Aug 2;104(8):1913-21. Epub 2009 Jun 2.

Division of Gastroenterology, University Hospitals - Case Medical Center, Case Western Reserve University School of Medicine, 11100 Euclid Avenue, Cleveland, Ohio 44106, USA.

View Article

Download full-text PDF

Source
http://www.nature.com/articles/ajg2009241
Publisher Site
http://dx.doi.org/10.1038/ajg.2009.241DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2864226PMC
August 2009

Comparative analysis of PCR-based biomarker assay methods for colorectal polyp detection from fecal DNA.

Clin Chem 2009 Aug 18;55(8):1559-63. Epub 2009 Jun 18.

Division of Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.

View Article

Download full-text PDF

Source
http://www.clinchem.org/cgi/doi/10.1373/clinchem.2008.122937
Publisher Site
http://dx.doi.org/10.1373/clinchem.2008.122937DOI Listing
August 2009

TGF-beta receptor levels regulate the specificity of signaling pathway activation and biological effects of TGF-beta.

Biochim Biophys Acta 2009 Jul 12;1793(7):1165-73. Epub 2009 Feb 12.

Clinical Research Division, Fred Hutchinson Cancer Research Center, WA 98109, USA.

View Article

Download full-text PDF

Source
http://linkinghub.elsevier.com/retrieve/pii/S016748890900038
Publisher Site
http://dx.doi.org/10.1016/j.bbamcr.2009.02.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2700179PMC
July 2009

Genomic and epigenetic instability in colorectal cancer pathogenesis.

Gastroenterology 2008 Oct 4;135(4):1079-99. Epub 2008 Sep 4.

Department of Medicine, University of Washington Medical School, Seattle, Washington, USA.

View Article

Download full-text PDF

Source
http://linkinghub.elsevier.com/retrieve/pii/S001650850801451
Publisher Site
http://dx.doi.org/10.1053/j.gastro.2008.07.076DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2866182PMC
October 2008

The aberrant methylation of TSP1 suppresses TGF-beta1 activation in colorectal cancer.

Int J Cancer 2008 Jul;123(1):14-21

Department of Cancer Biology, Vanderbilt University Medical School, Nashville, TN, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/ijc.23608DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2777657PMC
July 2008

CIMP and colon cancer gets more complicated.

Authors:
William M Grady

Gut 2007 Nov;56(11):1498-500

Clinical Research Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N. D4-100, Seattle, WA 98109, USA.

View Article

Download full-text PDF

Source
http://gut.bmj.com/cgi/doi/10.1136/gut.2007.125732
Publisher Site
http://dx.doi.org/10.1136/gut.2007.125732DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2095640PMC
November 2007

Consortium approach to identifying genes for Barrett's esophagus and esophageal adenocarcinoma.

Transl Res 2007 Jul 25;150(1):3-17. Epub 2007 May 25.

Department of Epidemiology and Biostatistics, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.trsl.2007.02.005DOI Listing
July 2007

Evidence for the role of aberrant DNA methylation in the pathogenesis of Lynch syndrome adenomas.

Int J Cancer 2007 May;120(9):1922-9

Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/ijc.22544DOI Listing
May 2007