Publications by authors named "William M Bonner"

83Publications

Histone H2AX promotes neuronal health by controlling mitochondrial homeostasis.

Proc Natl Acad Sci U S A 2019 04 25;116(15):7471-7476. Epub 2019 Mar 25.

The Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205;

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1073/pnas.1820245116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6462085PMC
April 2019

Histone H2AX deficiency causes neurobehavioral deficits and impaired redox homeostasis.

Nat Commun 2018 04 18;9(1):1526. Epub 2018 Apr 18.

The Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41467-018-03948-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5906610PMC
April 2018

p21: A Two-Faced Genome Guardian.

Trends Mol Med 2017 04 7;23(4):310-319. Epub 2017 Mar 7.

Developmental Therapeutics Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.molmed.2017.02.001DOI Listing
April 2017

Evaluation of surrogate tissues as indicators of drug activity in a melanoma skin model.

Cancer Med 2016 08 23;5(8):1731-41. Epub 2016 Jun 23.

Genomic Integrity Group, Laboratory of Molecular Pharmacology, National Cancer Institute, National Institutes of Health (NIH), Bethesda, Maryland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/cam4.726DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4971901PMC
August 2016

Twist1 and Slug mediate H2AX-regulated epithelial-mesenchymal transition in breast cells.

Cell Cycle 2016 Sep 17;15(18):2398-404. Epub 2016 Jun 17.

a Developmental Therapeutics Branch, Laboratory of Molecular Pharmacology, National Cancer Institute, National Institutes of Health , Bethesda , MD , USA.

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5026799PMC
http://dx.doi.org/10.1080/15384101.2016.1198864DOI Listing
September 2016

Effects of Breast Shielding during Heart Imaging on DNA Double-Strand-Break Levels: A Prospective Randomized Controlled Trial.

Radiology 2016 10 15;281(1):62-71. Epub 2016 Apr 15.

From the Department of Medicine (Cardiology Service) (M.K.C., A.S.K., J.B., T.C.V.) and Department of Radiology (B.N.), Walter Reed National Military Medical Center, 8901 Wisconsin Ave, Bethesda, MD 20889; Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, Bethesda, Md (C.E.R., A.S.B., D.M., H.B., W.M.B.); Institute of Biomedical Sciences, The George Washington University, Washington, DC (A.S.B.); George Mason University, Fairfax, Va (H.B.); Uniformed Services University of Health Sciences, Bethesda, Md (A.P., P.W.); and Department of Medicine, San Antonio Military Medical Center, San Antonio, Tex (P.D.).

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1148/radiol.2016152301DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5047130PMC
October 2016

H2AX and EMT: deciphering beyond DNA repair.

Cell Cycle 2016 05 17;15(10):1305-6. Epub 2016 Mar 17.

a Developmental Therapeutics Branch, Laboratory of Molecular Pharmacology, National Cancer Institute, National Institutes of Health , Bethesda , MD , USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/15384101.2016.1160659DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4889283PMC
May 2016

The histone variant H2A.X is a regulator of the epithelial-mesenchymal transition.

Nat Commun 2016 Feb 15;7:10711. Epub 2016 Feb 15.

Developmental Therapeutics Branch, Laboratory of Molecular Pharmacology, National Cancer Institute, National Institutes of Health, 37 Convent Drive, Bethesda, Maryland 20892, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/ncomms10711DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4756313PMC
February 2016

Evidence for chromosome fragility at the frataxin locus in Friedreich ataxia.

Mutat Res 2015 Nov 30;781:14-21. Epub 2015 Aug 30.

Section on Gene Structure and Disease, Laboratory of Cell and Molecular Biology, National Institute of Diabetes, Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.mrfmmm.2015.08.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4631761PMC
November 2015

Inactivation of NADPH oxidases NOX4 and NOX5 protects human primary fibroblasts from ionizing radiation-induced DNA damage.

Radiat Res 2015 Mar 23;183(3):262-70. Epub 2015 Feb 23.

a Laboratory of Molecular Pharmacology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1667/RR13799.1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4423734PMC
March 2015

NADPH oxidase 4 is a critical mediator in Ataxia telangiectasia disease.

Proc Natl Acad Sci U S A 2015 Feb 2;112(7):2121-6. Epub 2015 Feb 2.

Laboratory of Molecular Pharmacology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892; and

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1073/pnas.1418139112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4343117PMC
February 2015

Systemic DNA damage accumulation under in vivo tumor growth can be inhibited by the antioxidant Tempol.

Cancer Lett 2014 Oct 25;353(2):248-57. Epub 2014 Jul 25.

Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA; Division of Radiation Oncology and Cancer Imaging, Peter MacCallum Cancer Centre, Vic. 3002, Australia; Laboratory of Molecular Radiation Biology, Peter MacCallum Cancer Centre, Vic. 3002, Australia; Sir Peter MacCallum Department of Oncology, The University of Melbourne, Melbourne, Vic. 3002, Australia. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.canlet.2014.07.030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4167057PMC
October 2014

Evaluation of the gamma-H2AX assay for radiation biodosimetry in a swine model.

Int J Mol Sci 2013 Jul 8;14(7):14119-35. Epub 2013 Jul 8.

Armed Forces Radiobiology Research Institute, Uniformed Services University, Bethesda, MD 20889-5603, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/ijms140714119DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3742235PMC
July 2013

Susceptibility to bystander DNA damage is influenced by replication and transcriptional activity.

Nucleic Acids Res 2012 Nov 31;40(20):10274-86. Epub 2012 Aug 31.

Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20952, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/nar/gks795DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3488239PMC
November 2012

NADPH Oxidases NOXs and DUOXs as putative targets for cancer therapy.

Anticancer Agents Med Chem 2013 Mar;13(3):502-14

Laboratory of Molecular Pharmacology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365101PMC
March 2013

γ-H2AX and other histone post-translational modifications in the clinic.

Biochim Biophys Acta 2012 Jul 9;1819(7):743-56. Epub 2012 Mar 9.

Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, 9000 Rockville Pike, Bethesda, MD, 20892, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bbagrm.2012.02.021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3371125PMC
July 2012

SOD2 deficiency promotes aging phenotypes in mouse skin.

Aging (Albany NY) 2012 Feb;4(2):116-8

Laboratory of Molecular Pharmacology, CCR, NCI, NIH, Bethesda MD 20892, USA.

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3314173PMC
http://dx.doi.org/10.18632/aging.100433DOI Listing
February 2012

High salt and DNA double-strand breaks.

Proc Natl Acad Sci U S A 2011 Dec 12;108(51):20281-2. Epub 2011 Dec 12.

Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1073/pnas.1117713109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3251065PMC
December 2011

Systemic DNA damage related to cancer.

Cancer Res 2011 May 10;71(10):3437-41. Epub 2011 May 10.

Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/0008-5472.CAN-10-4579DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3096754PMC
May 2011

Para-inflammation mediates systemic DNA damage in response to tumor growth.

Commun Integr Biol 2011 Jan;4(1):78-81

Laboratory of Molecular Pharmacology; Center for Cancer Research; National Cancer Institute; Bethesda, MD USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4161/cib.4.1.13942DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3073278PMC
January 2011

Recent developments in the use of γ-H2AX as a quantitative DNA double-strand break biomarker.

Aging (Albany NY) 2011 Feb;3(2):168-74

Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA.

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3082012PMC
http://dx.doi.org/10.18632/aging.100284DOI Listing
February 2011

γH2AX foci as a measure of DNA damage: a computational approach to automatic analysis.

Mutat Res 2011 Jun 7;711(1-2):49-60. Epub 2011 Jan 7.

Trescowthick Research Laboratories, Peter MacCallum Cancer Centre, St. Andrew's Place, East Melbourne, Victoria 3002, Australia.

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3101310PMC
http://dx.doi.org/10.1016/j.mrfmmm.2010.12.015DOI Listing
June 2011

H2AX phosphorylation in response to DNA double-strand break formation during bystander signalling: effect of microRNA knockdown.

Radiat Prot Dosimetry 2011 Feb 23;143(2-4):264-9. Epub 2010 Dec 23.

Laboratory of Molecular Pharmacology, Center for Cancer Research, NCI, NIH, 9000 Rockville Pike, Bethesda, MD 20892, USA.

View Article

Download full-text PDF

Source
https://academic.oup.com/rpd/article-lookup/doi/10.1093/rpd/
Publisher Site
http://dx.doi.org/10.1093/rpd/ncq470DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3108274PMC
February 2011

The use of gamma-H2AX as a biodosimeter for total-body radiation exposure in non-human primates.

PLoS One 2010 Nov 23;5(11):e15544. Epub 2010 Nov 23.

Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0015544PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2990755PMC
November 2010

Development of a validated immunofluorescence assay for γH2AX as a pharmacodynamic marker of topoisomerase I inhibitor activity.

Clin Cancer Res 2010 Nov 5;16(22):5447-57. Epub 2010 Oct 5.

Laboratory of Human Toxicology and Pharmacology, Applied/Developmental Research Support Directorate, Science Applications International Corporation-Frederick, Inc., NationalCancer Institute-Frederick, Frederick, MD 21702, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/1078-0432.CCR-09-3076DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2982895PMC
November 2010

Tumors induce complex DNA damage in distant proliferative tissues in vivo.

Proc Natl Acad Sci U S A 2010 Oct 20;107(42):17992-7. Epub 2010 Sep 20.

Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1073/pnas.1008260107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2964229PMC
October 2010

Histone gammaH2AX and poly(ADP-ribose) as clinical pharmacodynamic biomarkers.

Clin Cancer Res 2010 Sep 7;16(18):4532-42. Epub 2010 Sep 7.

Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA.

View Article

Download full-text PDF

Source
http://clincancerres.aacrjournals.org/cgi/doi/10.1158/1078-0
Publisher Site
http://dx.doi.org/10.1158/1078-0432.CCR-10-0523DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2940983PMC
September 2010

γH2AX: Applications for the evaluation of telomerase-based cancer therapy.

Cell Cycle 2010 Sep 13;9(17):3385-6. Epub 2010 Sep 13.

Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4161/cc.9.17.13003DOI Listing
September 2010

microRNAome changes in bystander three-dimensional human tissue models suggest priming of apoptotic pathways.

Carcinogenesis 2010 Oct 19;31(10):1882-8. Epub 2010 Jul 19.

Department of Biological Sciences, University of Lethbridge, 4401 University Drive, Lethbridge, Alberta, T1K 3M4 Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/carcin/bgq119DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2950932PMC
October 2010

Telomere-dependent and telomere-independent origins of endogenous DNA damage in tumor cells.

Aging (Albany NY) 2009 Feb 4;1(2):212-8. Epub 2009 Feb 4.

Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2806003PMC
http://dx.doi.org/10.18632/aging.100019DOI Listing
February 2009

Role of oxidatively induced DNA lesions in human pathogenesis.

Mutat Res 2010 Apr-Jun;704(1-3):152-9. Epub 2010 Jan 8.

Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, 9000 Rockville Pike, Bethesda, MD 20892, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.mrrev.2009.12.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3074954PMC
August 2010

γ-H2AX as a biomarker of DNA damage induced by ionizing radiation in human peripheral blood lymphocytes and artificial skin.

Adv Space Res 2009 ;43(8):1171-1178

Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, D.H.H.S., Bethesda, Maryland 20892, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.asr.2008.10.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2735274PMC
January 2009

The complexity of phosphorylated H2AX foci formation and DNA repair assembly at DNA double-strand breaks.

Cell Cycle 2010 Jan 29;9(2):389-97. Epub 2010 Jan 29.

Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3086803PMC
http://dx.doi.org/10.4161/cc.9.2.10475DOI Listing
January 2010

H2AX: functional roles and potential applications.

Chromosoma 2009 Dec 26;118(6):683-92. Epub 2009 Aug 26.

Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00412-009-0234-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3094848PMC
December 2009

Intercellular communication of cellular stress monitored by gamma-H2AX induction.

Carcinogenesis 2009 Oct 3;30(10):1686-95. Epub 2009 Aug 3.

Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20952, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/carcin/bgp192DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2757548PMC
October 2009

The role of DNA damage response pathways in chromosome fragility in Fragile X syndrome.

Nucleic Acids Res 2009 Jul 21;37(13):4385-92. Epub 2009 May 21.

Section on Gene Structure and Disease, Laboratory of Molecular and Cellular Biology, National Institute of Diabetes, Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892-0830, USA.

View Article

Download full-text PDF

Source
https://nar.oxfordjournals.org/content/37/13/4385.full-text-
Web Search
http://nar.oxfordjournals.org/lookup/doi/10.1093/nar/gkp391
Publisher Site
http://dx.doi.org/10.1093/nar/gkp391DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2715245PMC
July 2009

Both telomeric and non-telomeric DNA damage are determinants of mammalian cellular senescence.

Epigenetics Chromatin 2008 Nov 3;1(1). Epub 2008 Nov 3.

Laboratory of Molecular Pharmacology, National Cancer Institute, National Institutes of Health, Rockville Pike, Bethesda, MD 20892, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/1756-8935-1-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2584625PMC
November 2008

GammaH2AX and cancer.

Nat Rev Cancer 2008 Dec 13;8(12):957-67. Epub 2008 Nov 13.

Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nrc2523DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3094856PMC
December 2008

Accumulation of oxidatively induced clustered DNA lesions in human tumor tissues.

Mutat Res 2009 Mar 2;674(1-2):131-6. Epub 2008 Oct 2.

Department of Biology, Thomas Harriot College of Arts and Sciences, East Carolina University, Greenville, NC 27858, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.mrgentox.2008.09.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6944316PMC
March 2009

Delayed kinetics of DNA double-strand break processing in normal and pathological aging.

Aging Cell 2008 Jan 19;7(1):89-100. Epub 2007 Dec 19.

Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1111/j.1474-9726.2007.00354.x
Publisher Site
http://dx.doi.org/10.1111/j.1474-9726.2007.00354.xDOI Listing
January 2008

gamma-H2AX in bystander cells: not just a radiation-triggered event, a cellular response to stress mediated by intercellular communication.

Cell Cycle 2007 Sep 5;6(18):2210-2. Epub 2007 Jul 5.

Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland 20895, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4161/cc.6.18.4682DOI Listing
September 2007

DNA double-strand breaks form in bystander cells after microbeam irradiation of three-dimensional human tissue models.

Cancer Res 2007 May;67(9):4295-302

Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland 20892, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/0008-5472.CAN-06-4442DOI Listing
May 2007

GammaH2AX in cancer cells: a potential biomarker for cancer diagnostics, prediction and recurrence.

Cell Cycle 2006 Dec 15;5(24):2909-13. Epub 2006 Dec 15.

Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland 20892, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4161/cc.5.24.3569DOI Listing
December 2006

Collaborative roles of gammaH2AX and the Rad51 paralog Xrcc3 in homologous recombinational repair.

DNA Repair (Amst) 2007 Mar 22;6(3):280-92. Epub 2006 Nov 22.

CREST Laboratory, Department of Radiation Genetics, Kyoto University Graduate School of Medicine, Kyoto 606-8501, Japan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.dnarep.2006.10.025DOI Listing
March 2007

The phosphorylation status of PAS-B distinguishes HIF-1alpha from HIF-2alpha in NBS1 repression.

EMBO J 2006 Oct 5;25(20):4784-94. Epub 2006 Oct 5.

Laboratory of Human Carcinogenesis, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/sj.emboj.7601369DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1618093PMC
October 2006

Techniques for gamma-H2AX detection.

Methods Enzymol 2006 ;409:236-50

Department of Environmental Sciences and Engineering, University of North Carolina, Chapel Hill, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/S0076-6879(05)09014-2DOI Listing
August 2006

DNA damage produced by 125I-triplex-forming oligonucleotides as a measure of their successful delivery into cell nuclei.

Ann N Y Acad Sci 2005 Nov;1058:140-50

Department of Nuclear Medicine, Clinical Center, Bethesda, Maryland 20892, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1196/annals.1359.022DOI Listing
November 2005

Ionizing radiation induces DNA double-strand breaks in bystander primary human fibroblasts.

Oncogene 2005 Nov;24(49):7257-65

Department of Nuclear Medicine, Clinical Center, NIH, 9000 Rockville Pike, Bethesda, MD 20892, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/sj.onc.1208886DOI Listing
November 2005

Assessment of DNA damage produced by 125I-triplex-forming oligonucleotides in cells.

Int J Radiat Biol 2004 Nov-Dec;80(11-12):927-31

NIH/NMD, 10 Center Dr., Room 4D45, Bethesda, MD 20892, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/09553000400017648DOI Listing
April 2005

Phenomena leading to cell survival values which deviate from linear-quadratic models.

Authors:
William M Bonner

Mutat Res 2004 Dec;568(1):33-9

Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 9000 Rockville Pike, Bldg 37 Rm 5050A MSC 4255, Bethesda, MD 20892, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.mrfmmm.2004.06.044DOI Listing
December 2004

Distribution and dynamics of chromatin modification induced by a defined DNA double-strand break.

Curr Biol 2004 Oct;14(19):1703-11

Laboratory of Biochemistry, Center for Cancer Research, National Cancer Institute, Building 37, Room 6124, Bethesda, MD 20892, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.cub.2004.09.047DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4493763PMC
October 2004

Two-dimensional gel analysis of histones and other H2AX-related methods.

Methods Enzymol 2004 ;375:76-88

Laboratory of Molecular Pharmacology, National Cancer Institute, Bethesda, Maryland 20892, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/s0076-6879(03)75005-8DOI Listing
March 2004

Senescing human cells and ageing mice accumulate DNA lesions with unrepairable double-strand breaks.

Nat Cell Biol 2004 Feb;6(2):168-70

Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, 20892, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/ncb1095DOI Listing
February 2004

Characteristics of gamma-H2AX foci at DNA double-strand breaks sites.

Biochem Cell Biol 2003 Jun;81(3):123-9

Laboratory of Molecular Pharmacology, National Cancer Institute, National Insitutes of Health, Bethesda, MD 20892, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1139/o03-042DOI Listing
June 2003

Histone H2AX in DNA damage and repair.

Cancer Biol Ther 2003 May-Jun;2(3):233-5

Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4161/cbt.2.3.373DOI Listing
December 2003

Yeast histone 2A serine 129 is essential for the efficient repair of checkpoint-blind DNA damage.

EMBO Rep 2003 Jul;4(7):678-84

Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/sj.embor.embor871DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1326317PMC
July 2003

Histone H2AX phosphorylation is dispensable for the initial recognition of DNA breaks.

Nat Cell Biol 2003 Jul;5(7):675-9

Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA.

View Article

Download full-text PDF

Source
http://search.proquest.com/openview/1be2f8d6df92df91fa7da769
Web Search
http://dx.doi.org/10.1038/ncb1004DOI Listing
July 2003

Low-dose radiation: thresholds, bystander effects, and adaptive responses.

Authors:
William M Bonner

Proc Natl Acad Sci U S A 2003 Apr 18;100(9):4973-5. Epub 2003 Apr 18.

Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Building 37, Room 5050A, MSC 4255, 9000 Rockville Pike, Bethesda, MD 20892, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1073/pnas.1031538100DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC154280PMC
April 2003

H2AX is required for chromatin remodeling and inactivation of sex chromosomes in male mouse meiosis.

Dev Cell 2003 Apr;4(4):497-508

Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/s1534-5807(03)00093-5DOI Listing
April 2003

DNA damage-induced G2-M checkpoint activation by histone H2AX and 53BP1.

Nat Cell Biol 2002 Dec;4(12):993-7

Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/ncb884DOI Listing
December 2002

Quantitative detection of (125)IdU-induced DNA double-strand breaks with gamma-H2AX antibody.

Radiat Res 2002 Oct;158(4):486-92

Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland 20892, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1667/0033-7587(2002)158[0486:qdoiid]2.0.co;2DOI Listing
October 2002

UV-induced replication arrest in the xeroderma pigmentosum variant leads to DNA double-strand breaks, gamma -H2AX formation, and Mre11 relocalization.

Proc Natl Acad Sci U S A 2002 Jan 26;99(1):233-8. Epub 2001 Dec 26.

Department of Radiation Oncology, University of California, San Francisco, CA 94103-0806,USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1073/pnas.231611798DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC117544PMC
January 2002