William M Abraham

William M Abraham

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William M Abraham

William M Abraham

Publications by authors named "William M Abraham"

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Electronic Cigarette Vapor with Nicotine Causes Airway Mucociliary Dysfunction Preferentially via TRPA1 Receptors.

Am J Respir Crit Care Med 2019 Jun 7. Epub 2019 Jun 7.

University of Kansas Medical Center Department of Internal Medicine, 189695, Pulmonary and Critical Care Medicine, Kansas City, Kansas, United States.

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http://dx.doi.org/10.1164/rccm.201811-2087OCDOI Listing
June 2019

Evaluation of a SPLUNC1-derived peptide for the treatment of cystic fibrosis lung disease.

Am J Physiol Lung Cell Mol Physiol 2018 01 5;314(1):L192-L205. Epub 2017 Oct 5.

Cystic Fibrosis Center/Marsico Lung Institute, The University of North Carolina at Chapel Hill , Chapel Hill, North Carolina.

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http://dx.doi.org/10.1152/ajplung.00546.2016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5866433PMC
January 2018

Kinin B1 receptor antagonist BI113823 reduces allergen-induced airway inflammation and mucus secretion in mice.

Pharmacol Res 2016 Feb 30;104:132-9. Epub 2015 Dec 30.

Department of BIN Convergence Technology, Chonbuk National University, South Korea; Department of Research Mount Sinai Medical Center, Miami Beach, FL, USA. Electronic address:

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http://dx.doi.org/10.1016/j.phrs.2015.12.017DOI Listing
February 2016

Effect of the potent and selective DP1 receptor antagonist, asapiprant (S-555739), in animal models of allergic rhinitis and allergic asthma.

Eur J Pharmacol 2015 Oct 12;765:15-23. Epub 2015 Aug 12.

Discovery Research Laboratory for Innovative Frontier Medicines, Shionogi & Co., Ltd., Toyonaka, Osaka, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.ejphar.2015.08.003DOI Listing
October 2015

Heparin-derived supersulfated disaccharide inhibits allergic airway responses in sheep.

Pulm Pharmacol Ther 2014 Jun 17;28(1):77-86. Epub 2013 Dec 17.

Department of Research, Mount Sinai Medical Center, 4300 Alton Rd. Miami Beach, Miami Beach, FL 33140, USA. Electronic address:

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http://dx.doi.org/10.1016/j.pupt.2013.12.001DOI Listing
June 2014

Structure activity relationship of brevenal hydrazide derivatives.

Mar Drugs 2014 Mar 28;12(4):1839-58. Epub 2014 Mar 28.

Center for Marine Science, University of North Carolina Wilmington (UNCW), 5600 Marvin K. Moss Lane, Wilmington, NC 28409, USA.

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http://dx.doi.org/10.3390/md12041839DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4012454PMC
March 2014

Sabiporide improves cardiovascular function, decreases the inflammatory response and reduces mortality in acute metabolic acidosis in pigs.

PLoS One 2013 10;8(1):e53932. Epub 2013 Jan 10.

Department of Research, Division of Neonatology, Mount Sinai Medical Center, Miami Beach, Florida, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0053932PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3542271PMC
July 2013

NHE1 inhibition improves tissue perfusion and resuscitation outcome after severe hemorrhage.

J Surg Res 2013 May 31;181(2):e75-81. Epub 2012 Jul 31.

Division of Neonatology, Department of Research, Mount Sinai Medical Center, Miami Beach, Florida 33140, USA.

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http://dx.doi.org/10.1016/j.jss.2012.07.026DOI Listing
May 2013

Effect of oral and intravenous heparin tetrasaccharide on allergic airway responses: critical role of N-sulfation.

Pulm Pharmacol Ther 2013 Apr 22;26(2):180-8. Epub 2012 Oct 22.

Department of Research, Mount Sinai Medical Center, 4300 Alton Rd., Miami Beach, FL 33140, USA.

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http://dx.doi.org/10.1016/j.pupt.2012.10.004DOI Listing
April 2013

Inhibition of allergic airway responses by heparin derived oligosaccharides: identification of a tetrasaccharide sequence.

Respir Res 2012 Jan 23;13. Epub 2012 Jan 23.

Department of Research, Mount Sinai Medical Center, Miami Beach, Florida, USA.

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http://dx.doi.org/10.1186/1465-9921-13-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3296655PMC
January 2012

Repeated exposure to aerosolized brevetoxin-3 induces prolonged airway hyperresponsiveness and lung inflammation in sheep.

Inhal Toxicol 2011 Mar;23(4):205-11

University of Miami, Miller School of Medicine, Division of Comparative Pathology, Miami, Florida, 33140 USA.

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http://dx.doi.org/10.3109/08958378.2011.558936DOI Listing
March 2011

Receptor-mediated enhancement of beta adrenergic drug activity by ascorbate in vitro and in vivo.

PLoS One 2010 Dec 13;5(12):e15130. Epub 2010 Dec 13.

Department of Physiology, Michigan State University, East Lansing, Michigan, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0015130PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3001466PMC
December 2010

Characterization of tamulamides A and B, polyethers isolated from the marine dinoflagellate Karenia brevis.

J Nat Prod 2010 Apr;73(4):536-40

Department of Oceanography, University of Washington, P.O. Box 357940, Seattle, Washington 98195, USA.

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http://dx.doi.org/10.1021/np900541wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2881462PMC
April 2010

Resuscitation with Na+/H+ exchanger inhibitor in traumatic haemorrhagic shock: cardiopulmonary performance, oxygen transport and tissue inflammation.

Clin Exp Pharmacol Physiol 2010 Mar 21;37(3):337-42. Epub 2009 Sep 21.

Department of Research, Division of Neonatology, Mount Sinai Medical Center, Miami Beach, FL, USA.

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http://dx.doi.org/10.1111/j.1440-1681.2009.05296.xDOI Listing
March 2010

Dual inhibition of cathepsin G and chymase is effective in animal models of pulmonary inflammation.

Am J Respir Crit Care Med 2010 Feb 29;181(3):247-53. Epub 2009 Oct 29.

Johnson & Johnson Pharmaceutical Research & Development, Welsh and McKean Roads, Spring House, PA 19477-0076, USA.

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http://dx.doi.org/10.1164/rccm.200904-0627OCDOI Listing
February 2010

Specific inhibition of tissue kallikrein 1 with a human monoclonal antibody reveals a potential role in airway diseases.

Biochem J 2009 Aug 13;422(2):383-92. Epub 2009 Aug 13.

Discovery Research, Dyax Corp., 300 Technology Square, Cambridge, MA 02139, USA.

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http://dx.doi.org/10.1042/BJ20090010DOI Listing
August 2009

Exposure and effect assessment of aerosolized red tide toxins (brevetoxins) and asthma.

Environ Health Perspect 2009 Jul 13;117(7):1095-100. Epub 2009 Apr 13.

National Science Foundation National Institute of Environmental Health Sciences Oceans and Human Health Center, University of Miami Rosenstiel School of Marine and Atmospheric Sciences, Miami, Florida 33136, USA.

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http://isurus.mote.org/niehsredtidestudy/Exposure%20and%20Ef
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http://ehp.niehs.nih.gov/0900673
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http://dx.doi.org/10.1289/ehp.0900673DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2717136PMC
July 2009

Low-volume resuscitation from traumatic hemorrhagic shock with Na+/H+ exchanger inhibitor.

Crit Care Med 2009 Jun;37(6):1994-9

Department of Research, Division of Neonatology, Mount Sinai Medical Center, Miller School of Medicine, University of Miami, Miami Beach, FL, USA.

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http://dx.doi.org/10.1097/CCM.0b013e3181a0052eDOI Listing
June 2009

Modeling of asthma, COPD and cystic fibrosis in sheep.

Pulm Pharmacol Ther 2008 Oct 6;21(5):743-54. Epub 2008 Feb 6.

Department of Research, Mount Sinai Medical Center, 4300 Alton Road, Miami Beach, FL 33140, USA.

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http://dx.doi.org/10.1016/j.pupt.2008.01.010DOI Listing
October 2008

The porcine lung as a potential model for cystic fibrosis.

Am J Physiol Lung Cell Mol Physiol 2008 Aug 16;295(2):L240-63. Epub 2008 May 16.

Department of Internal Medicine, Roy J. Carver College of Medicine, University of Iowa, Iowa City, Iowa 52242, USA.

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http://dx.doi.org/10.1152/ajplung.90203.2008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2519845PMC
August 2008

Na+/H+ exchange inhibition delays the onset of hypovolemic circulatory shock in pigs.

Shock 2008 Apr;29(4):519-25

Department of Research, Division of Neonatology, Mount Sinai Medical Canter, Miami Beach, Florida 33140, USA.

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http://dx.doi.org/10.1097/shk.0b013e318150757aDOI Listing
April 2008

Synthesis, modeling, and biological evaluation of analogues of the semisynthetic brevetoxin antagonist beta-naphthoyl-brevetoxin.

Chembiochem 2007 Dec;8(18):2233-9

Center for Marine Science, University of North Carolina Wilmington, 5600 Marvin. K. Moss Lane, Wilmington, NC 28409, USA.

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http://dx.doi.org/10.1002/cbic.200700317DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2613567PMC
December 2007

Hyaluronan blocks porcine pancreatic elastase-induced mucociliary dysfunction in allergic sheep.

J Appl Physiol (1985) 2007 Jun 29;102(6):2324-31. Epub 2007 Mar 29.

Division of Pulmonary and Critical Care Medicine, Miller School of Medicine, University of Miami at Mount Sinai Medical Center, Miami Beach, FL 33140, USA.

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http://www.physiology.org/doi/10.1152/japplphysiol.00568.200
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http://dx.doi.org/10.1152/japplphysiol.00568.2006DOI Listing
June 2007

Efficacy of IL-13 neutralization in a sheep model of experimental asthma.

Am J Respir Cell Mol Biol 2007 Mar 5;36(3):368-76. Epub 2006 Oct 5.

Department of Inflammation, Wyeth Research, 200 CambridgePark Drive, Cambridge, MA 02140, USA.

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http://dx.doi.org/10.1165/rcmb.2006-0244OCDOI Listing
March 2007

Aerosolized red-tide toxins (brevetoxins) and asthma.

Chest 2007 Jan;131(1):187-94

National Institute of Environmental Health Sciences Marine and Freshwater Biomedical Sciences Center, Rosenstiel School of Marine and Atmospheric Sciences, University of Miami, Miami, FL, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S001236921549898
Publisher Site
http://dx.doi.org/10.1378/chest.06-1830DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2683400PMC
January 2007

Whole-body periodic acceleration modifies experimental asthma in sheep.

Am J Respir Crit Care Med 2006 Oct 20;174(7):743-52. Epub 2006 Jul 20.

Division of Pulmonary Disease and Critical Care Medicine, University of Miami at Mount Sinai Medical Center, Miami Beach, FL 33140, USA.

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http://dx.doi.org/10.1164/rccm.200601-048OCDOI Listing
October 2006

Selection of a 2-azabicyclo[2.2.2]octane-based alpha4beta1 integrin antagonist as an inhaled anti-asthmatic agent.

Bioorg Med Chem 2006 Jun 21;14(12):4208-16. Epub 2006 Feb 21.

Research & Early Development, Johnson & Johnson Pharmaceutical Research & Development, Welsh and McKean Roads, Spring House, PA 19477-0776, USA.

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http://dx.doi.org/10.1016/j.bmc.2006.01.067DOI Listing
June 2006

Aerosolized Florida Red Tide Toxins and Human Health Effects.

Oceanography (Wash D C) 2006 Jun;19(2):107-109

Mount Sinai Medical Center and Professor of Medicine, Miller School of Medicine, University of Miami, Miami Beach, FL, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3081595PMC
June 2006

Peptide and non-peptide bradykinin receptor antagonists: role in allergic airway disease.

Eur J Pharmacol 2006 Mar 7;533(1-3):215-21. Epub 2006 Feb 7.

Miller School of Medicine, University of Miami at Mount Sinai Medical Center, 4300 Alton Road, Miami Beach, Florida 33140, USA.

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http://dx.doi.org/10.1016/j.ejphar.2005.12.071DOI Listing
March 2006

Comparative effects of salmeterol, albuterol, and ipratropium on normal and impaired mucociliary function in sheep.

Chest 2005 Nov;128(5):3743-9

Division of Pulmonary and Critical Care Medicine, Miller School of Medicine, University of Miami at Mount Sinai Medical Center, FL 33140, USA.

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http://dx.doi.org/10.1378/chest.128.5.3743DOI Listing
November 2005

Effects of inhaled brevetoxins in allergic airways: toxin-allergen interactions and pharmacologic intervention.

Environ Health Perspect 2005 May;113(5):632-7

Division of Pulmonary and Critical Care Medicine, University of Miami at Mount Sinai Medical Center, 4300 Alton Road, Miami Beach, FL 33140, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1257560PMC
http://dx.doi.org/10.1289/ehp.7498DOI Listing
May 2005

Therapeutic targeting of endothelial ligands for L-selectin (PNAd) in a sheep model of asthma.

Am J Pathol 2005 Mar;166(3):935-44

Department of Anatomy, University of California, San Francisco, CA 94143-0452, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1602362PMC
http://dx.doi.org/10.1016/S0002-9440(10)62313-9DOI Listing
March 2005

Airway responses to aerosolized brevetoxins in an animal model of asthma.

Am J Respir Crit Care Med 2005 Jan 24;171(1):26-34. Epub 2004 Sep 24.

Department of Research, Mount Sinai Medical Center, 4300 Alton Road, Miami Beach, FL 33140, USA.

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http://dx.doi.org/10.1164/rccm.200406-735OCDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2650266PMC
January 2005

Evaluation of second generation amiloride analogs as therapy for cystic fibrosis lung disease.

J Pharmacol Exp Ther 2004 Dec 23;311(3):929-38. Epub 2004 Jul 23.

Parion Sciences Inc., 2525 Meridian Parkway, Suite 260, Durham, NC 27713, USA.

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http://dx.doi.org/10.1124/jpet.104.071886DOI Listing
December 2004

Hyaluronan blocks human neutrophil elastase (HNE)-induced airway responses in sheep.

Pulm Pharmacol Ther 2003 ;16(6):335-40

Division of Pulmonary and Critical Care Medicine, University of Miami at Mount Sinai Medical Center, 4300 Alton Road, Miami Beach, FL 33140, USA.

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http://dx.doi.org/10.1016/S1094-5539(03)00089-0DOI Listing
June 2004

Leukocytic cell sources of airway tissue kallikrein.

Am J Physiol Lung Cell Mol Physiol 2004 Apr 5;286(4):L734-40. Epub 2003 Dec 5.

Dept. of Research, Mount Sinai Medical Center, 4300 Alton Rd., Miami Beach, FL 33140, USA.

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http://dx.doi.org/10.1152/ajplung.00129.2003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2650278PMC
April 2004

A monoclonal antibody to alpha1beta1 blocks antigen-induced airway responses in sheep.

Am J Respir Crit Care Med 2004 Jan 24;169(1):97-104. Epub 2003 Oct 24.

Division of Pulmonary Disease and Critical Care Medicine, University of Miami at Mount Sinai Medical Center, Miami Beach, Florida 33140, USA.

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http://dx.doi.org/10.1164/rccm.200304-543OCDOI Listing
January 2004

Of mice and men.

Am J Respir Cell Mol Biol 2003 Jan;28(1):1-4

Division of Pulmonary and Critical Care Medicine, University of Miami School of Medicine at Mount Sinai Medical Center, Miami Beach, Florida 33140, USA.

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January 2003

Montelukast prevents antigen-induced mucociliary dysfunction in sheep.

Am J Respir Crit Care Med 2002 Dec 17;166(11):1457-60. Epub 2002 Sep 17.

Division of Pulmonary and Critical Care Medicine, University of Miami at Mount Sinai Medical Center, Miami Beach, Florida 33140, USA.

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http://www.atsjournals.org/doi/abs/10.1164/rccm.200205-387OC
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http://dx.doi.org/10.1164/rccm.200205-387OCDOI Listing
December 2002

Recombinant alpha 1-proteinase inhibitor blocks antigen- and mediator-induced airway responses in sheep.

J Appl Physiol (1985) 2002 Dec;93(6):1900-6

Division of Pulmonary and Critical Care Medicine, University of Miami at Mount Sinai Medical Center, Miami Beach, Florida 33140, USA.

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http://dx.doi.org/10.1152/japplphysiol.00400.2002DOI Listing
December 2002

Identification of potent and novel alpha4beta1 antagonists using in silico screening.

J Med Chem 2002 Jul;45(14):2988-93

Department of Drug Design and Evaluation, Biogen Inc., 12 Cambridge Center, Cambridge, MA 02142, USA.

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http://dx.doi.org/10.1021/jm020054eDOI Listing
July 2002

Tryptase: potential role in airway inflammation and remodeling.

Am J Physiol Lung Cell Mol Physiol 2002 Feb;282(2):L193-6

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http://dx.doi.org/10.1152/ajplung.00429.2001DOI Listing
February 2002

Exercise-Induced Muscle Soreness.

Phys Sportsmed 1979 Oct;7(10):57-66

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http://dx.doi.org/10.1080/00913847.1979.11948501DOI Listing
October 1979