William L Lowe

William L Lowe

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William L Lowe

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Maternal and fetal genetic effects on birth weight and their relevance to cardio-metabolic risk factors.

Authors:
Nicole M Warrington Robin N Beaumont Momoko Horikoshi Felix R Day Øyvind Helgeland Charles Laurin Jonas Bacelis Shouneng Peng Ke Hao Bjarke Feenstra Andrew R Wood Anubha Mahajan Jessica Tyrrell Neil R Robertson N William Rayner Zhen Qiao Gunn-Helen Moen Marc Vaudel Carmen J Marsit Jia Chen Michael Nodzenski Theresia M Schnurr Mohammad H Zafarmand Jonathan P Bradfield Niels Grarup Marjolein N Kooijman Ruifang Li-Gao Frank Geller Tarunveer S Ahluwalia Lavinia Paternoster Rico Rueedi Ville Huikari Jouke-Jan Hottenga Leo-Pekka Lyytikäinen Alana Cavadino Sarah Metrustry Diana L Cousminer Ying Wu Elisabeth Thiering Carol A Wang Christian T Have Natalia Vilor-Tejedor Peter K Joshi Jodie N Painter Ioanna Ntalla Ronny Myhre Niina Pitkänen Elisabeth M van Leeuwen Raimo Joro Vasiliki Lagou Rebecca C Richmond Ana Espinosa Sheila J Barton Hazel M Inskip John W Holloway Loreto Santa-Marina Xavier Estivill Wei Ang Julie A Marsh Christoph Reichetzeder Letizia Marullo Berthold Hocher Kathryn L Lunetta Joanne M Murabito Caroline L Relton Manolis Kogevinas Leda Chatzi Catherine Allard Luigi Bouchard Marie-France Hivert Ge Zhang Louis J Muglia Jani Heikkinen Camilla S Morgen Antoine H C van Kampen Barbera D C van Schaik Frank D Mentch Claudia Langenberg Jian'an Luan Robert A Scott Jing Hua Zhao Gibran Hemani Susan M Ring Amanda J Bennett Kyle J Gaulton Juan Fernandez-Tajes Natalie R van Zuydam Carolina Medina-Gomez Hugoline G de Haan Frits R Rosendaal Zoltán Kutalik Pedro Marques-Vidal Shikta Das Gonneke Willemsen Hamdi Mbarek Martina Müller-Nurasyid Marie Standl Emil V R Appel Cilius E Fonvig Caecilie Trier Catharina E M van Beijsterveldt Mario Murcia Mariona Bustamante Sílvia Bonas-Guarch David M Hougaard Josep M Mercader Allan Linneberg Katharina E Schraut Penelope A Lind Sarah E Medland Beverley M Shields Bridget A Knight Jin-Fang Chai Kalliope Panoutsopoulou Meike Bartels Friman Sánchez Jakob Stokholm David Torrents Rebecca K Vinding Sara M Willems Mustafa Atalay Bo L Chawes Peter Kovacs Inga Prokopenko Marcus A Tuke Hanieh Yaghootkar Katherine S Ruth Samuel E Jones Po-Ru Loh Anna Murray Michael N Weedon Anke Tönjes Michael Stumvoll Kim F Michaelsen Aino-Maija Eloranta Timo A Lakka Cornelia M van Duijn Wieland Kiess Antje Körner Harri Niinikoski Katja Pahkala Olli T Raitakari Bo Jacobsson Eleftheria Zeggini George V Dedoussis Yik-Ying Teo Seang-Mei Saw Grant W Montgomery Harry Campbell James F Wilson Tanja G M Vrijkotte Martine Vrijheid Eco J C N de Geus M Geoffrey Hayes Haja N Kadarmideen Jens-Christian Holm Lawrence J Beilin Craig E Pennell Joachim Heinrich Linda S Adair Judith B Borja Karen L Mohlke Johan G Eriksson Elisabeth E Widén Andrew T Hattersley Tim D Spector Mika Kähönen Jorma S Viikari Terho Lehtimäki Dorret I Boomsma Sylvain Sebert Peter Vollenweider Thorkild I A Sørensen Hans Bisgaard Klaus Bønnelykke Jeffrey C Murray Mads Melbye Ellen A Nohr Dennis O Mook-Kanamori Fernando Rivadeneira Albert Hofman Janine F Felix Vincent W V Jaddoe Torben Hansen Charlotta Pisinger Allan A Vaag Oluf Pedersen André G Uitterlinden Marjo-Riitta Järvelin Christine Power Elina Hyppönen Denise M Scholtens William L Lowe George Davey Smith Nicholas J Timpson Andrew P Morris Nicholas J Wareham Hakon Hakonarson Struan F A Grant Timothy M Frayling Debbie A Lawlor Pål R Njølstad Stefan Johansson Ken K Ong Mark I McCarthy John R B Perry David M Evans Rachel M Freathy

Nat Genet 2019 05 1;51(5):804-814. Epub 2019 May 1.

Institute of Biomedical and Clinical Science, College of Medicine and Health, University of Exeter, Royal Devon and Exeter Hospital, Exeter, UK.

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http://dx.doi.org/10.1038/s41588-019-0403-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6522365PMC
May 2019

Gestational Diabetes and Childhood Obesity-Reply.

JAMA 2019 02;321(7):708-709

Northwestern University Feinberg School of Medicine, Chicago, Illinois.

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http://dx.doi.org/10.1001/jama.2018.19754DOI Listing
February 2019

Genome-wide association study of offspring birth weight in 86 577 women identifies five novel loci and highlights maternal genetic effects that are independent of fetal genetics.

Hum Mol Genet 2018 02;27(4):742-756

Institute of Biomedical and Clinical Science, University of Exeter Medical School, University of Exeter, Royal Devon and Exeter Hospital, Exeter EX2 5DW, UK.

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http://dx.doi.org/10.1093/hmg/ddx429DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5886200PMC
February 2018

Genetic determinants of adiponectin regulation revealed by pregnancy.

Obesity (Silver Spring) 2017 05 20;25(5):935-944. Epub 2017 Mar 20.

Department of Medicine, Division of Endocrinology, Metabolism and Molecular Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.

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http://dx.doi.org/10.1002/oby.21805DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5404994PMC
May 2017

Transversions have larger regulatory effects than transitions.

BMC Genomics 2017 05 19;18(1):394. Epub 2017 May 19.

Center for Genomic and Computational Biology, Duke University Medical School, Durham, NC, 27710, USA.

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http://dx.doi.org/10.1186/s12864-017-3785-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5438547PMC
May 2017

Mixture model normalization for non-targeted gas chromatography/mass spectrometry metabolomics data.

BMC Bioinformatics 2017 Feb 2;18(1):84. Epub 2017 Feb 2.

Department of Preventive Medicine, Division of Biostatistics, Northwestern University Feinberg School of Medicine, Chicago, IL, 60611, USA.

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http://dx.doi.org/10.1186/s12859-017-1501-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5290663PMC
February 2017

Associations Between Fetal Imprinted Genes and Maternal Blood Pressure in Pregnancy.

Hypertension 2016 12 24;68(6):1459-1466. Epub 2016 Oct 24.

From the Department of Paediatrics (C.J.P., N.S.M., G.P., I.A.H., C.L.A., K.K.O., D.B.D.), Medical Research Council Epidemiology Unit (K.K.O.), and Institute of Metabolic Science (D.B.D.), University of Cambridge, United Kingdom; Hospital Sant Joan de Déu, Servicio de Pediatría, Barcelona, Spain (N.S.M.); Divisão de Endocrinologia Pediátrica, Departamento de Pediatria, Faculdade de Medicina da Universidade Federal de Minas Gerais, Belo Horizonte, Brazil (G.P.); and Division of Endocrinology, Metabolism and Molecular Medicine, Department of Medicine (M.G.H., W.L.L.) and Division of Biostatistics, Department of Preventive Medicine (M.N., D.M.S.), Northwestern University Feinberg School of Medicine, Chicago, IL.

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http://dx.doi.org/10.1161/HYPERTENSIONAHA.116.08261DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5159231PMC
December 2016

Genome-wide associations for birth weight and correlations with adult disease.

Authors:
Momoko Horikoshi Robin N Beaumont Felix R Day Nicole M Warrington Marjolein N Kooijman Juan Fernandez-Tajes Bjarke Feenstra Natalie R van Zuydam Kyle J Gaulton Niels Grarup Jonathan P Bradfield David P Strachan Ruifang Li-Gao Tarunveer S Ahluwalia Eskil Kreiner Rico Rueedi Leo-Pekka Lyytikäinen Diana L Cousminer Ying Wu Elisabeth Thiering Carol A Wang Christian T Have Jouke-Jan Hottenga Natalia Vilor-Tejedor Peter K Joshi Eileen Tai Hui Boh Ioanna Ntalla Niina Pitkänen Anubha Mahajan Elisabeth M van Leeuwen Raimo Joro Vasiliki Lagou Michael Nodzenski Louise A Diver Krina T Zondervan Mariona Bustamante Pedro Marques-Vidal Josep M Mercader Amanda J Bennett Nilufer Rahmioglu Dale R Nyholt Ronald Ching Wan Ma Claudia Ha Ting Tam Wing Hung Tam Santhi K Ganesh Frank Ja van Rooij Samuel E Jones Po-Ru Loh Katherine S Ruth Marcus A Tuke Jessica Tyrrell Andrew R Wood Hanieh Yaghootkar Denise M Scholtens Lavinia Paternoster Inga Prokopenko Peter Kovacs Mustafa Atalay Sara M Willems Kalliope Panoutsopoulou Xu Wang Lisbeth Carstensen Frank Geller Katharina E Schraut Mario Murcia Catharina Em van Beijsterveldt Gonneke Willemsen Emil V R Appel Cilius E Fonvig Caecilie Trier Carla Mt Tiesler Marie Standl Zoltán Kutalik Sílvia Bonas-Guarch David M Hougaard Friman Sánchez David Torrents Johannes Waage Mads V Hollegaard Hugoline G de Haan Frits R Rosendaal Carolina Medina-Gomez Susan M Ring Gibran Hemani George McMahon Neil R Robertson Christopher J Groves Claudia Langenberg Jian'an Luan Robert A Scott Jing Hua Zhao Frank D Mentch Scott M MacKenzie Rebecca M Reynolds William L Lowe Anke Tönjes Michael Stumvoll Virpi Lindi Timo A Lakka Cornelia M van Duijn Wieland Kiess Antje Körner Thorkild Ia Sørensen Harri Niinikoski Katja Pahkala Olli T Raitakari Eleftheria Zeggini George V Dedoussis Yik-Ying Teo Seang-Mei Saw Mads Melbye Harry Campbell James F Wilson Martine Vrijheid Eco Jcn de Geus Dorret I Boomsma Haja N Kadarmideen Jens-Christian Holm Torben Hansen Sylvain Sebert Andrew T Hattersley Lawrence J Beilin John P Newnham Craig E Pennell Joachim Heinrich Linda S Adair Judith B Borja Karen L Mohlke Johan G Eriksson Elisabeth E Widén Mika Kähönen Jorma S Viikari Terho Lehtimäki Peter Vollenweider Klaus Bønnelykke Hans Bisgaard Dennis O Mook-Kanamori Albert Hofman Fernando Rivadeneira André G Uitterlinden Charlotta Pisinger Oluf Pedersen Christine Power Elina Hyppönen Nicholas J Wareham Hakon Hakonarson Eleanor Davies Brian R Walker Vincent Wv Jaddoe Marjo-Riitta Jarvelin Struan Fa Grant Allan A Vaag Debbie A Lawlor Timothy M Frayling George Davey Smith Andrew P Morris Ken K Ong Janine F Felix Nicholas J Timpson John Rb Perry David M Evans Mark I McCarthy Rachel M Freathy

Nature 2016 10 28;538(7624):248-252. Epub 2016 Sep 28.

Institute of Biomedical and Clinical Science, University of Exeter Medical School, Royal Devon and Exeter Hospital, Exeter, UK.

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http://dx.doi.org/10.1038/nature19806DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5164934PMC
October 2016

HKDC1 Is a Novel Hexokinase Involved in Whole-Body Glucose Use.

Endocrinology 2016 09 26;157(9):3452-61. Epub 2016 Jul 26.

Division of Endocrinology, Metabolism, and Molecular Medicine (A.E.L., C.M.P., M.P., A.R.A., K.S.H., W.L.L., B.T.L.), Department of Pathology (A.L., G.-Y.Y.), Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611; Department of Biostatistics and Bioinformatics (T.E.R.), and Center for Genomic and Computational Biology (C.G., T.E.R.), Duke University Medical School, and University Program in Genetics and Genomics (C.G.), Duke University, Durham, North Carolina 27710; Department of Pathology (X.D.), Loyola University Chicago, Maywood, Illinois 60153; and Jesse Brown Veterans Affairs Medical Center (B.T.L.), Chicago, Illinois 60612.

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http://dx.doi.org/10.1210/en.2016-1288DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5007896PMC
September 2016

Trans-ethnic Meta-analysis and Functional Annotation Illuminates the Genetic Architecture of Fasting Glucose and Insulin.

Authors:
Ching-Ti Liu Sridharan Raghavan Nisa Maruthur Edmond Kato Kabagambe Jaeyoung Hong Maggie C Y Ng Marie-France Hivert Yingchang Lu Ping An Amy R Bentley Anne M Drolet Kyle J Gaulton Xiuqing Guo Loren L Armstrong Marguerite R Irvin Man Li Leonard Lipovich Denis V Rybin Kent D Taylor Charles Agyemang Nicholette D Palmer Brian E Cade Wei-Min Chen Marco Dauriz Joseph A C Delaney Todd L Edwards Daniel S Evans Michele K Evans Leslie A Lange Aaron Leong Jingmin Liu Yongmei Liu Uma Nayak Sanjay R Patel Bianca C Porneala Laura J Rasmussen-Torvik Marieke B Snijder Sarah C Stallings Toshiko Tanaka Lisa R Yanek Wei Zhao Diane M Becker Lawrence F Bielak Mary L Biggs Erwin P Bottinger Donald W Bowden Guanjie Chen Adolfo Correa David J Couper Dana C Crawford Mary Cushman John D Eicher Myriam Fornage Nora Franceschini Yi-Ping Fu Mark O Goodarzi Omri Gottesman Kazuo Hara Tamara B Harris Richard A Jensen Andrew D Johnson Min A Jhun Andrew J Karter Margaux F Keller Abel N Kho Jorge R Kizer Ronald M Krauss Carl D Langefeld Xiaohui Li Jingling Liang Simin Liu William L Lowe Thomas H Mosley Kari E North Jennifer A Pacheco Patricia A Peyser Alan L Patrick Kenneth M Rice Elizabeth Selvin Mario Sims Jennifer A Smith Salman M Tajuddin Dhananjay Vaidya Mary P Wren Jie Yao Xiaofeng Zhu Julie T Ziegler Joseph M Zmuda Alan B Zonderman Aeilko H Zwinderman Adebowale Adeyemo Eric Boerwinkle Luigi Ferrucci M Geoffrey Hayes Sharon L R Kardia Iva Miljkovic James S Pankow Charles N Rotimi Michele M Sale Lynne E Wagenknecht Donna K Arnett Yii-Der Ida Chen Michael A Nalls Michael A Province W H Linda Kao David S Siscovick Bruce M Psaty James G Wilson Ruth J F Loos Josée Dupuis Stephen S Rich Jose C Florez Jerome I Rotter Andrew P Morris James B Meigs

Am J Hum Genet 2016 Jul 16;99(1):56-75. Epub 2016 Jun 16.

Division of General Internal Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ajhg.2016.05.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5005440PMC
July 2016

Genetic Evidence for Causal Relationships Between Maternal Obesity-Related Traits and Birth Weight.

JAMA 2016 Mar;315(11):1129-40

Institute of Biomedical and Clinical Science, University of Exeter Medical School, Royal Devon and Exeter Hospital, Exeter, United Kingdom5Medical Research Council Integrative Epidemiology Unit at the University of Bristol, United Kingdom.

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http://dx.doi.org/10.1001/jama.2016.1975DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4811305PMC
March 2016

Genetics of Gestational Diabetes Mellitus and Maternal Metabolism.

Curr Diab Rep 2016 Feb;16(2):15

Division of Endocrinology, Metabolism, and Molecular Medicine and Department of Medicine, Northwestern University Feinberg School of Medicine, Rubloff Building 420 E. Superior St., 12th Floor, Chicago, IL, 60611, USA.

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http://dx.doi.org/10.1007/s11892-015-0709-zDOI Listing
February 2016

The short-chain fatty acid receptor, FFA2, contributes to gestational glucose homeostasis.

Am J Physiol Endocrinol Metab 2015 Nov 22;309(10):E840-51. Epub 2015 Sep 22.

Division of Endocrinology, Metabolism and Molecular Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois; Jesse Brown Veterans Affairs Medical Center, Chicago, Illinois

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http://dx.doi.org/10.1152/ajpendo.00171.2015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4838121PMC
November 2015

Genomic approaches for understanding the genetics of complex disease.

Genome Res 2015 Oct;25(10):1432-41

Department of Biostatistics and Bioinformatics, Duke University Medical School, Durham, North Carolina 27708, USA; Center for Genomic and Computational Biology, Duke University Medical School, Durham, North Carolina 27708, USA.

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http://genome.cshlp.org/content/25/10/1432.full.pdf+html
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http://genome.cshlp.org/lookup/doi/10.1101/gr.190603.115
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http://dx.doi.org/10.1101/gr.190603.115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4579328PMC
October 2015

Massively parallel quantification of the regulatory effects of noncoding genetic variation in a human cohort.

Genome Res 2015 Aug 17;25(8):1206-14. Epub 2015 Jun 17.

Program in Computational Biology and Bioinformatics, Duke University, Durham, North Carolina 27710, USA; Department of Biostatistics and Bioinformatics, Duke University Medical School, Durham, North Carolina 27710, USA.

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http://dx.doi.org/10.1101/gr.190090.115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4510004PMC
August 2015

Characterization of large structural genetic mosaicism in human autosomes.

Authors:
Mitchell J Machiela Weiyin Zhou Joshua N Sampson Michael C Dean Kevin B Jacobs Amanda Black Louise A Brinton I-Shou Chang Chu Chen Constance Chen Kexin Chen Linda S Cook Marta Crous Bou Immaculata De Vivo Jennifer Doherty Christine M Friedenreich Mia M Gaudet Christopher A Haiman Susan E Hankinson Patricia Hartge Brian E Henderson Yun-Chul Hong H Dean Hosgood Chao A Hsiung Wei Hu David J Hunter Lea Jessop Hee Nam Kim Yeul Hong Kim Young Tae Kim Robert Klein Peter Kraft Qing Lan Dongxin Lin Jianjun Liu Loic Le Marchand Xiaolin Liang Jolanta Lissowska Lingeng Lu Anthony M Magliocco Keitaro Matsuo Sara H Olson Irene Orlow Jae Yong Park Loreall Pooler Jennifer Prescott Radhai Rastogi Harvey A Risch Fredrick Schumacher Adeline Seow Veronica Wendy Setiawan Hongbing Shen Xin Sheng Min-Ho Shin Xiao-Ou Shu David VanDen Berg Jiu-Cun Wang Nicolas Wentzensen Maria Pik Wong Chen Wu Tangchun Wu Yi-Long Wu Lucy Xia Hannah P Yang Pan-Chyr Yang Wei Zheng Baosen Zhou Christian C Abnet Demetrius Albanes Melinda C Aldrich Christopher Amos Laufey T Amundadottir Sonja I Berndt William J Blot Cathryn H Bock Paige M Bracci Laurie Burdett Julie E Buring Mary A Butler Tania Carreón Nilanjan Chatterjee Charles C Chung Michael B Cook Michael Cullen Faith G Davis Ti Ding Eric J Duell Caroline G Epstein Jin-Hu Fan Jonine D Figueroa Joseph F Fraumeni Neal D Freedman Charles S Fuchs Yu-Tang Gao Susan M Gapstur Ana Patiño-Garcia Montserrat Garcia-Closas J Michael Gaziano Graham G Giles Elizabeth M Gillanders Edward L Giovannucci Lynn Goldin Alisa M Goldstein Mark H Greene Goran Hallmans Curtis C Harris Roger Henriksson Elizabeth A Holly Robert N Hoover Nan Hu Amy Hutchinson Mazda Jenab Christoffer Johansen Kay-Tee Khaw Woon-Puay Koh Laurence N Kolonel Charles Kooperberg Vittorio Krogh Robert C Kurtz Andrea LaCroix Annelie Landgren Maria Teresa Landi Donghui Li Linda M Liao Nuria Malats Katherine A McGlynn Lorna H McNeill Robert R McWilliams Beatrice S Melin Lisa Mirabello Beata Peplonska Ulrike Peters Gloria M Petersen Ludmila Prokunina-Olsson Mark Purdue You-Lin Qiao Kari G Rabe Preetha Rajaraman Francisco X Real Elio Riboli Benjamín Rodríguez-Santiago Nathaniel Rothman Avima M Ruder Sharon A Savage Ann G Schwartz Kendra L Schwartz Howard D Sesso Gianluca Severi Debra T Silverman Margaret R Spitz Victoria L Stevens Rachael Stolzenberg-Solomon Daniel Stram Ze-Zhong Tang Philip R Taylor Lauren R Teras Geoffrey S Tobias Kala Viswanathan Sholom Wacholder Zhaoming Wang Stephanie J Weinstein William Wheeler Emily White John K Wiencke Brian M Wolpin Xifeng Wu Jay S Wunder Kai Yu Krista A Zanetti Anne Zeleniuch-Jacquotte Regina G Ziegler Mariza de Andrade Kathleen C Barnes Terri H Beaty Laura J Bierut Karl C Desch Kimberly F Doheny Bjarke Feenstra David Ginsburg John A Heit Jae H Kang Cecilia A Laurie Jun Z Li William L Lowe Mary L Marazita Mads Melbye Daniel B Mirel Jeffrey C Murray Sarah C Nelson Louis R Pasquale Kenneth Rice Janey L Wiggs Anastasia Wise Margaret Tucker Luis A Pérez-Jurado Cathy C Laurie Neil E Caporaso Meredith Yeager Stephen J Chanock

Am J Hum Genet 2015 Mar;96(3):487-97

Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD 20892, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ajhg.2015.01.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4375431PMC
March 2015

A novel common variant in DCST2 is associated with length in early life and height in adulthood.

Authors:
Ralf J P van der Valk Eskil Kreiner-Møller Marjolein N Kooijman Mònica Guxens Evangelia Stergiakouli Annika Sääf Jonathan P Bradfield Frank Geller M Geoffrey Hayes Diana L Cousminer Antje Körner Elisabeth Thiering John A Curtin Ronny Myhre Ville Huikari Raimo Joro Marjan Kerkhof Nicole M Warrington Niina Pitkänen Ioanna Ntalla Momoko Horikoshi Riitta Veijola Rachel M Freathy Yik-Ying Teo Sheila J Barton David M Evans John P Kemp Beate St Pourcain Susan M Ring George Davey Smith Anna Bergström Inger Kull Hakon Hakonarson Frank D Mentch Hans Bisgaard Bo Chawes Jakob Stokholm Johannes Waage Patrick Eriksen Astrid Sevelsted Mads Melbye Cornelia M van Duijn Carolina Medina-Gomez Albert Hofman Johan C de Jongste H Rob Taal André G Uitterlinden Loren L Armstrong Johan Eriksson Aarno Palotie Mariona Bustamante Xavier Estivill Juan R Gonzalez Sabrina Llop Wieland Kiess Anubha Mahajan Claudia Flexeder Carla M T Tiesler Clare S Murray Angela Simpson Per Magnus Verena Sengpiel Anna-Liisa Hartikainen Sirkka Keinanen-Kiukaanniemi Alexandra Lewin Alexessander Da Silva Couto Alves Alexandra I Blakemore Jessica L Buxton Marika Kaakinen Alina Rodriguez Sylvain Sebert Marja Vaarasmaki Timo Lakka Virpi Lindi Ulrike Gehring Dirkje S Postma Wei Ang John P Newnham Leo-Pekka Lyytikäinen Katja Pahkala Olli T Raitakari Kalliope Panoutsopoulou Eleftheria Zeggini Dorret I Boomsma Maria Groen-Blokhuis Jorma Ilonen Lude Franke Joel N Hirschhorn Tune H Pers Liming Liang Jinyan Huang Berthold Hocher Mikael Knip Seang-Mei Saw John W Holloway Erik Melén Struan F A Grant Bjarke Feenstra William L Lowe Elisabeth Widén Elena Sergeyev Harald Grallert Adnan Custovic Bo Jacobsson Marjo-Riitta Jarvelin Mustafa Atalay Gerard H Koppelman Craig E Pennell Harri Niinikoski George V Dedoussis Mark I Mccarthy Timothy M Frayling Jordi Sunyer Nicholas J Timpson Fernando Rivadeneira Klaus Bønnelykke Vincent W V Jaddoe

Hum Mol Genet 2015 Feb 3;24(4):1155-68. Epub 2014 Oct 3.

Department of Epidemiology, Department of Paediatrics, The Generation R Study Group,

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http://hmg.oxfordjournals.org/content/early/2014/10/03/hmg.d
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http://www.copsac.com/userfiles/2015_Van_der_Valk_Hum_Mol_Ge
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http://www.uni-potsdam.de/fileadmin/projects/eem/Paper_2015/
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http://www.hmg.oxfordjournals.org/cgi/doi/10.1093/hmg/ddu510
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http://dx.doi.org/10.1093/hmg/ddu510DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4447786PMC
February 2015

New insights into gestational glucose metabolism: lessons learned from 21st century approaches.

Diabetes 2015 Feb;64(2):327-34

Division of Endocrinology, Metabolism and Molecular Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL Jesse Brown Veterans Affairs Medical Center, Chicago, IL

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http://dx.doi.org/10.2337/db14-0877DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4876793PMC
February 2015

Coordinated regulatory variation associated with gestational hyperglycaemia regulates expression of the novel hexokinase HKDC1.

Nat Commun 2015 Feb 4;6:6069. Epub 2015 Feb 4.

1] Center for Genomic &Computational Biology, Duke University School of Medicine, Durham, North Carolina 27708, USA [2] Department of Biostatistics &Bioinformatics, Duke University Medical School, Durham, North Carolina 27710, USA.

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http://dx.doi.org/10.1038/ncomms7069DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4318120PMC
February 2015

Metabomxtr: an R package for mixture-model analysis of non-targeted metabolomics data.

Bioinformatics 2014 Nov 29;30(22):3287-8. Epub 2014 Jul 29.

Department of Preventive Medicine, Division of Biostatistics, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, Sarah W. Stedman Nutrition and Metabolism Center, Duke Molecular Physiology Institute and Division of Endocrinology, Metabolism, and Nutrition, Department of Medicine, Duke University Medical Center, Durham, NC 27704 and Department of Medicine, Division of Endocrinology, Metabolism, and Molecular Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611.

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http://bioinformatics.oxfordjournals.org/content/early/2014/
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http://bioinformatics.oxfordjournals.org/cgi/doi/10.1093/bio
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http://dx.doi.org/10.1093/bioinformatics/btu509DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4221120PMC
November 2014

Genetic risk score for prediction of newborn adiposity and large-for-gestational-age birth.

J Clin Endocrinol Metab 2014 Nov 19;99(11):E2377-86. Epub 2014 Aug 19.

Division of Pediatric Endocrinology, Ann & Robert H. Lurie Children's Hospital of Chicago (R.C.), Department of Preventive Medicine (S.E.B., J.R., A.C.R., L.P.L., D.M.S.), Division of Endocrinology, Metabolism & Molecular Medicine (L.L.A., M.U., B.E.M., M.G.H., W.L.L.), Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611; and PhD (cand) (S.B.), University of Washington, Seattle, Washington 355852.

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https://academic.oup.com/jcem/article-lookup/doi/10.1210/jc.
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http://dx.doi.org/10.1210/jc.2013-4221DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4223445PMC
November 2014

Impact on offspring methylation patterns of maternal gestational diabetes mellitus and intrauterine growth restraint suggest common genes and pathways linked to subsequent type 2 diabetes risk.

FASEB J 2014 Nov 21;28(11):4868-79. Epub 2014 Aug 21.

National Institute for Health Research Cambridge Biomedical Research Centre, Wellcome Trust-MRC Institute of Metabolic Science, Department of Paediatrics, University of Cambridge, Cambridge, UK; and.

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http://www.fasebj.org/content/early/2014/08/20/fj.14-255240.
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http://www.fasebj.org/cgi/doi/10.1096/fj.14-255240
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http://dx.doi.org/10.1096/fj.14-255240DOI Listing
November 2014

Meta-analysis of genome-wide association studies in African Americans provides insights into the genetic architecture of type 2 diabetes.

PLoS Genet 2014 Aug 7;10(8):e1004517. Epub 2014 Aug 7.

Center for Genomics and Personalized Medicine Research, Wake Forest School of Medicine, Winston-Salem, North Carolina, United States of America; Center for Diabetes Research, Wake Forest School of Medicine, Winston-Salem, North Carolina, United States of America; Department of Biochemistry, Wake Forest School of Medicine, Winston-Salem, North Carolina, United States of America.

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http://dx.doi.org/10.1371/journal.pgen.1004517DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4125087PMC
August 2014

Porous scaffolds support extrahepatic human islet transplantation, engraftment, and function in mice.

Cell Transplant 2013 ;22(5):811-9

Institute of Bionanotechnology in Medicine (IBNAM), Northwestern University, Chicago, IL, USA.

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http://dx.doi.org/10.3727/096368912X636966DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3701739PMC
December 2013

Collagen IV-modified scaffolds improve islet survival and function and reduce time to euglycemia.

Tissue Eng Part A 2013 Nov 27;19(21-22):2361-72. Epub 2013 Jun 27.

1 Department of Biomedical Engineering, Northwestern University , Evanston, Illinois.

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http://dx.doi.org/10.1089/ten.TEA.2013.0033DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3807710PMC
November 2013

Accumulation of cadmium in insulin-producing β cells.

Islets 2012 Nov-Dec;4(6):405-16. Epub 2012 Nov 1.

Division of Endocrinology, Metabolism and Molecular Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3605169PMC
September 2013

"Prediction is very hard, especially about the future": new biomarkers for type 2 diabetes?

Diabetes 2013 May;62(5):1384-5

Division of Endocrinology, Metabolism, and Molecular Medicine, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.

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http://dx.doi.org/10.2337/db13-0057DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3636630PMC
May 2013

Short chain fatty acids and their receptors: new metabolic targets.

Transl Res 2013 Mar 9;161(3):131-40. Epub 2012 Nov 9.

Division of Endocrinology, Metabolism and Molecular Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611-3008, USA.

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http://dx.doi.org/10.1016/j.trsl.2012.10.007DOI Listing
March 2013

Negative association of acetate with visceral adipose tissue and insulin levels.

Diabetes Metab Syndr Obes 2012 28;5:49-55. Epub 2012 Feb 28.

Division of Endocrinology, Metabolism and Molecular Medicine (BTL, SKY, AD, WLL), Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.

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http://dx.doi.org/10.2147/DMSO.S29244DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3299553PMC
October 2012

The role of inflammatory pathway genetic variation on maternal metabolic phenotypes during pregnancy.

PLoS One 2012 30;7(3):e32958. Epub 2012 Mar 30.

Division of Endocrinology, Metabolism and Molecular Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States of America.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3316547PMC
August 2012

Ethnic variation in allele distribution of the androgen receptor (AR) (CAG)n repeat.

J Androl 2012 Mar-Apr;33(2):210-5. Epub 2011 May 19.

Division of Endocrinology, Metabolism, and Molecular Medicine, Northwestern University, Feinberg School of Medicine, 303 E Chicago Ave, Chicago, IL 60611, USA.

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http://dx.doi.org/10.2164/jandrol.111.013391DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3833274PMC
May 2012

Detectable clonal mosaicism from birth to old age and its relationship to cancer.

Nat Genet 2012 May 6;44(6):642-50. Epub 2012 May 6.

Department of Biostatistics, University of Washington, Seattle, Washington, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3366033PMC
May 2012

Extrahepatic islet transplantation with microporous polymer scaffolds in syngeneic mouse and allogeneic porcine models.

Biomaterials 2011 Dec 28;32(36):9677-84. Epub 2011 Sep 28.

Institute of Bionanotechnology in Medicine, Northwestern University, Chicago, IL 60611, USA.

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http://dx.doi.org/10.1016/j.biomaterials.2011.08.084DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3195897PMC
December 2011

Inflammatory mediators and glucose in pregnancy: results from a subset of the Hyperglycemia and Adverse Pregnancy Outcome (HAPO) Study.

J Clin Endocrinol Metab 2010 Dec 15;95(12):5427-34. Epub 2010 Sep 15.

Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, 680 North Lake Shore Drive, Suite 1400, Chicago, Illinois 60611, USA.

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http://dx.doi.org/10.1210/jc.2010-1662DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2999969PMC
December 2010

Acute cytokine-mediated downregulation of the zinc transporter ZnT8 alters pancreatic beta-cell function.

J Endocrinol 2010 Aug 27;206(2):159-69. Epub 2010 May 27.

Division of Endocrinology, Metabolism and Molecular Medicine, Feinberg School of Medicine, Northwestern University, 303 East Chicago Avenue, Tarry 15-755, Chicago, Illinois 60611, USA.

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http://dx.doi.org/10.1677/JOE-09-0420DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3088990PMC
August 2010

G protein coupled receptors in embryonic stem cells: a role for Gs-alpha signaling.

PLoS One 2010 Feb 8;5(2):e9105. Epub 2010 Feb 8.

Department of Medicine, Division of Endocrinology, Metabolism and Molecular Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States of America.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2816999PMC
February 2010

Anti-inflammatory peptide-functionalized hydrogels for insulin-secreting cell encapsulation.

Biomaterials 2010 Jan 25;31(2):308-14. Epub 2009 Sep 25.

Department of Biomedical Engineering, Northwestern University, 2145 Sheridan Road, Evanston, IL 60208, USA.

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http://dx.doi.org/10.1016/j.biomaterials.2009.09.045DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2784009PMC
January 2010

Layered PLG scaffolds for in vivo plasmid delivery.

Biomaterials 2009 Jan 17;30(3):394-401. Epub 2008 Oct 17.

Department of Chemical and Biological Engineering, Northwestern University, 2145 Sheridan Road, Tech E136, Evanston, IL 60208, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S014296120800649
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http://dx.doi.org/10.1016/j.biomaterials.2008.09.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2642007PMC
January 2009

Rapamycin inhibits growth factor-induced cell cycle regulation in pancreatic beta cells.

J Investig Med 2008 Dec;56(8):985-96

Department of Medicine, Division of Endocrinology, Metabolism and Molecular Medicine, Northwestern University Feinberg School of Medicine, chicago, IL 60611, USA.

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http://dx.doi.org/10.2310/JIM.0b013e31818ce763DOI Listing
December 2008

Extracellular matrix protein-coated scaffolds promote the reversal of diabetes after extrahepatic islet transplantation.

Transplantation 2008 May;85(10):1456-64

Department of Chemical and Biological Engineering, Northwestern University, Evanston, IL 60208-3120, USA.

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http://dx.doi.org/10.1097/TP.0b013e31816fc0eaDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2597660PMC
May 2008

Polymer scaffolds as synthetic microenvironments for extrahepatic islet transplantation.

Transplantation 2006 Aug;82(4):452-9

Department of Medicine, Division of Endocrinology, Metabolism and Molecular Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.

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http://dx.doi.org/10.1097/01.tp.0000231708.19937.21DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2648394PMC
August 2006

Role of the mitogen-activated protein kinases in cytokine-mediated inhibition of insulin gene expression.

J Investig Med 2006 Apr;54(3):132-42

Department of Medicine, Northwestern University Feinberg School of Medicine, 303 East Chicago Avenue, Chicago, IL 60611, USA.

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http://dx.doi.org/10.2310/6650.2006.05035DOI Listing
April 2006

"The matrix unloaded": implications for cytokine signaling in islets?

Authors:
William L Lowe

Endocrinology 2003 Oct;144(10):4262-3

Division of Endocrinology, Metabolism, and Molecular Medicine, Northwestern University, Feinberg School of Medicine, Tarry 15-703, 303 East Chicago Avenue, Chicago, Illinois 60611, USA.

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http://dx.doi.org/10.1210/en.2003-0884DOI Listing
October 2003

Clinical islet transplantation.

Curr Diab Rep 2003 Aug;3(4):344-50

Feinberg School of Medicine, Northwestern University, Galter Pavilion, #17-200, 675 N. St. Clair Street, Chicago, IL 60611, USA.

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August 2003

Activation of phosphatidylinositol 3-kinase contributes to insulin-like growth factor I-mediated inhibition of pancreatic beta-cell death.

Endocrinology 2002 Oct;143(10):3802-12

Department of Medicine, Veterans Affairs Chicago Healthcare System, Lakeside Division, Chicago, Illinois 60611, USA.

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http://dx.doi.org/10.1210/en.2002-220058DOI Listing
October 2002