Publications by authors named "William K Funkhouser"

57Publications

Interpathologist Diagnostic Agreement for Non-Small Cell Lung Carcinomas Using Current and Recent Classifications.

Arch Pathol Lab Med 2018 12 30;142(12):1537-1548. Epub 2018 Apr 30.

From the Department of Pathology & Laboratory Medicine, University of North Carolina School of Medicine, Chapel Hill (Drs Funkhouser Jr and Banks); Lineberger Comprehensive Cancer Center, UNC, Chapel Hill, North Carolina (Drs Funkhouser Jr, Hayes, Nikolaishvilli-Feinberg, and Grilley-Olson; Messrs Moore and Jo; and Ms Eeva); the Department of Medicine, UNC School of Medicine, Chapel Hill, North Carolina (Drs Hayes and Grilley-Olson); the Department of Computer Sciences, University of Wisconsin, Madison (Mr Funkhouser III); the Department of Biostatistics, UNC School of Public Health, Chapel Hill, North Carolina (Dr Fine); Medical Affairs, Ventana Medical Systems, Tucson, Arizona (Dr Banks); Unit of Pathology, Scientific Institute for Research and Health Care, San Giovanni Rotondo, Italy (Dr Graziano); the Department of Pathology, VA Medical Center, Durham, North Carolina (Dr Boswell); the Department of Medical Biosciences, Pathology, Umeå University Hospital, Umeå, Sweden (Dr Elmberger); the Department of Pathology, Kaiser-Permanente Hospital, Santa Clara, California (Dr Raparia); the Department of Pathology, Piedmont Medical Center, Rock Hill, South Carolina (Dr Hart); the Department of Pathology, Brigham and Women's Hospital, Boston, Massachusetts (Dr Sholl); the Department of Pathology, Suburban Hospital, Bethesda, Maryland (Dr Nolan); the Department of Pathology, Mayo Clinic, Rochester, Minnesota (Dr Fritchie); the Department of Pathology, VA Medical Center, Dayton, Ohio (Dr Pouagare); the Department of Pathology, University of Texas Medical Branch, Galveston (Dr Allen); the Department of Pathology, Rex Hospital, Raleigh, North Carolina (Dr Volmar); the Department of Pathology, Medical College of Georgia, Augusta (Drs Biddinger and Kleven); the Department of Pathology, Flagstaff Medical Center, Flagstaff, Arizona (Dr Papez); the Department of Pathology, VA Medical Center, Charleston, South Carolina (Dr Spencer); the Department of Pathology, Memorial Sloan-Kettering Cancer Center, New York, New York (Dr Rekhtman); the Department of Pathology, Massachusetts General Hospital, Boston (Drs Mino-Kenudson and Hariri); and the Department of Pathology & Genomic Medicine, Houston Methodist Hospital, Houston, Texas (Drs Driver and Cagle). Dr Allen is currently located at the Department of Pathology at University of Mississippi Medical Center, Jackson.

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December 2018

Molecular Biomarkers for the Evaluation of Colorectal Cancer: Guideline Summary From the American Society for Clinical Pathology, College of American Pathologists, Association for Molecular Pathology, and American Society of Clinical Oncology.

J Oncol Pract 2017 05 28;13(5):333-337. Epub 2017 Mar 28.

Columbia University, New York; Roswell Park Cancer Institute, Buffalo, NY; University of Texas MD Anderson Cancer Center, Houston; Castle Biosciences, Friendswood, TX; University of Florida Medical Center, Gainesville, FL; University of California Los Angeles Medical Center, Los Angeles; Biocept, San Diego, CA; University of Nebraska Medical Center, Omaha, NE; University of North Carolina School of Medicine, Chapel Hill, NC; University of Colorado Denver School of Medicine, Denver, CO; Mayo Clinic, Scottsdale, AZ; Mayo Clinic, Rochester, MN; Case Western Reserve University, Cleveland, OH; American Society for Clinical Pathology, Washington, DC; College of American Pathologists, Northfield, IL; American Society of Clinical Oncology, Alexandria, VA; and Association for Molecular Pathology, Bethesda, MD.

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May 2017

Molecular Biomarkers for the Evaluation of Colorectal Cancer: Guideline From the American Society for Clinical Pathology, College of American Pathologists, Association for Molecular Pathology, and the American Society of Clinical Oncology.

J Clin Oncol 2017 May 6;35(13):1453-1486. Epub 2017 Feb 6.

Antonia R. Sepulveda, Columbia University, New York, NY; Stanley R. Hamilton, Scott E. Kopetz, and Bruce D. Minsky, University of Texas MD Anderson Cancer Center, Houston, TX; Carmen J. Allegra, University of Florida Medical Center, Gainesville, FL; Wayne Grody, UCLA Medical Center, Los Angeles, CA; Allison M. Cushman-Vokoun, University of Nebraska Medical Center, Omaha, NE; William K. Funkhouser, University of North Carolina School of Medicine, Chapel Hill, NC; Christopher Lieu, University of Colorado Denver School of Medicine, Denver, CO; Noralane M. Lindor, Mayo Clinic, Scottsdale, AZ; Federico A. Monzon, Castle Biosciences, Friendswood, TX; Daniel J. Sargent, Mayo Clinic, Rochester, MN; Veena M. Singh, Biocept, San Diego, CA; Joseph Willis, Case Western Reserve University, Cleveland, OH; Jennifer Clark, American Society for Clinical Pathology, Washington, DC; Carol Colasacco and Christina B. Ventura, College of American Pathologists, Northfield, IL; R. Bryan Rumble, American Society of Clinical Oncology, Alexandria, VA; Robyn Temple-Smolkin, Association for Molecular Pathology, Bethesda, MD; and Jan A. Nowak, Roswell Park Cancer Institute, Buffalo, NY.

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May 2017

Metachronous Bilateral Testicular Leydig-Like Tumors Leading to the Diagnosis of Congenital Adrenal Hyperplasia (Adrenogenital Syndrome).

Case Rep Pathol 2015 16;2015:459318. Epub 2015 Aug 16.

Lineberger Comprehensive Cancer Center, Chapel Hill, NC 27599, USA ; Department of Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill, NC 27599, USA.

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September 2015

A non-BRICHOS SFTPC mutant (SP-CI73T) linked to interstitial lung disease promotes a late block in macroautophagy disrupting cellular proteostasis and mitophagy.

Am J Physiol Lung Cell Mol Physiol 2015 Jan 24;308(1):L33-47. Epub 2014 Oct 24.

Pulmonary, Allergy, and Critical Care Division, Department of Medicine, University of Pennsylvania, Perelman School of Medicine, Philadelphia, Pennsylvania;

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January 2015

Polymorphous low-grade adenocarcinoma: a case series and determination of recurrence.

Laryngoscope 2014 Dec 17;124(12):2714-9. Epub 2014 Sep 17.

Department of Otolaryngology/Head and Neck Surgery, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, U.S.A.

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December 2014

Alterations of LKB1 and KRAS and risk of brain metastasis: comprehensive characterization by mutation analysis, copy number, and gene expression in non-small-cell lung carcinoma.

Lung Cancer 2014 Nov 30;86(2):255-61. Epub 2014 Aug 30.

The Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, United States; Department of Internal Medicine, Division of Hematology/Oncology, Multidisciplinary Thoracic Oncology Program, University of North Carolina at Chapel Hill, United States. Electronic address:

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November 2014

Single nucleotide polymorphisms in nucleotide excision repair genes, cancer treatment, and head and neck cancer survival.

Cancer Causes Control 2014 Apr 2;25(4):437-50. Epub 2014 Feb 2.

Department of Epidemiology, Gillings School of Global Pubic Health, University of North Carolina at Chapel Hill, 2101B McGavran-Greenberg Hall, CB 7435, Chapel Hill, NC, 27599, USA,

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April 2014

Body mass index and risk of head and neck cancer by race: the Carolina Head and Neck Cancer Epidemiology Study.

Ann Epidemiol 2014 Feb 16;24(2):160-164.e1. Epub 2013 Nov 16.

Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC; Department of Otolaryngology/Head and Neck Surgery, School of Medicine, University of North Carolina, Chapel Hill, NC; Lineberger Comprehensive Cancer Center, School of Medicine, University of North Carolina, Chapel Hill, NC.

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February 2014

ERCC1 protein expression is associated with differential survival in oropharyngeal head and neck squamous cell carcinoma.

Otolaryngol Head Neck Surg 2013 Oct 11;149(4):587-95. Epub 2013 Jul 11.

Department of Otolaryngology/Head and Neck Surgery, University of North Carolina School of Medicine, Chapel Hill, North Carolina, USA.

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October 2013

Single-nucleotide polymorphisms in nucleotide excision repair genes, cigarette smoking, and the risk of head and neck cancer.

Cancer Epidemiol Biomarkers Prev 2013 Aug 29;22(8):1428-45. Epub 2013 May 29.

Department of Epidemiology, University of North Carolina Gillings School of Global Public Health, Chapel Hill, North Carolina 27599, USA.

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August 2013

Effects of polymorphisms in alcohol metabolism and oxidative stress genes on survival from head and neck cancer.

Cancer Epidemiol 2013 Aug 28;37(4):479-91. Epub 2013 Apr 28.

Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.

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August 2013

Racial differences in the relationship between tobacco, alcohol, and squamous cell carcinoma of the head and neck.

Cancer Causes Control 2013 Apr 7;24(4):649-64. Epub 2012 Jun 7.

Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC 27599-7435, USA.

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April 2013

Associations between dietary patterns and head and neck cancer: the Carolina head and neck cancer epidemiology study.

Am J Epidemiol 2012 Jun 10;175(12):1225-33. Epub 2012 May 10.

Department of Nutrition, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, USA.

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June 2012

Relevance, pathogenesis, and testing algorithm for mismatch repair-defective colorectal carcinomas: a report of the association for molecular pathology.

J Mol Diagn 2012 Mar-Apr;14(2):91-103. Epub 2012 Jan 17.

Mismatch Repair-Defective CRC Working Group of the Association for Molecular Pathology Clinical Practice Committee, University of North Carolina, Chapel Hill, North Carolina, USA.

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June 2012

Phospho-ERK and AKT status, but not KRAS mutation status, are associated with outcomes in rectal cancer treated with chemoradiotherapy.

Radiat Oncol 2011 Sep 12;6:114. Epub 2011 Sep 12.

Department of Medicine, Division of Hematology/Oncology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7305, USA.

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September 2011

A genome-wide association study of upper aerodigestive tract cancers conducted within the INHANCE consortium.

Authors:
James D McKay Therese Truong Valerie Gaborieau Amelie Chabrier Shu-Chun Chuang Graham Byrnes David Zaridze Oxana Shangina Neonila Szeszenia-Dabrowska Jolanta Lissowska Peter Rudnai Eleonora Fabianova Alexandru Bucur Vladimir Bencko Ivana Holcatova Vladimir Janout Lenka Foretova Pagona Lagiou Dimitrios Trichopoulos Simone Benhamou Christine Bouchardy Wolfgang Ahrens Franco Merletti Lorenzo Richiardi Renato Talamini Luigi Barzan Kristina Kjaerheim Gary J Macfarlane Tatiana V Macfarlane Lorenzo Simonato Cristina Canova Antonio Agudo Xavier Castellsagué Ray Lowry David I Conway Patricia A McKinney Claire M Healy Mary E Toner Ariana Znaor Maria Paula Curado Sergio Koifman Ana Menezes Victor Wünsch-Filho José Eluf Neto Leticia Fernández Garrote Stefania Boccia Gabriella Cadoni Dario Arzani Andrew F Olshan Mark C Weissler William K Funkhouser Jingchun Luo Jan Lubiński Joanna Trubicka Marcin Lener Dorota Oszutowska Stephen M Schwartz Chu Chen Sherianne Fish David R Doody Joshua E Muscat Philip Lazarus Carla J Gallagher Shen-Chih Chang Zuo-Feng Zhang Qingyi Wei Erich M Sturgis Li-E Wang Silvia Franceschi Rolando Herrero Karl T Kelsey Michael D McClean Carmen J Marsit Heather H Nelson Marjorie Romkes Shama Buch Tomoko Nukui Shilong Zhong Martin Lacko Johannes J Manni Wilbert H M Peters Rayjean J Hung John McLaughlin Lars Vatten Inger Njølstad Gary E Goodman John K Field Triantafillos Liloglou Paolo Vineis Francoise Clavel-Chapelon Domenico Palli Rosario Tumino Vittorio Krogh Salvatore Panico Carlos A González J Ramón Quirós Carmen Martínez Carmen Navarro Eva Ardanaz Nerea Larrañaga Kay-Tee Khaw Timothy Key H Bas Bueno-de-Mesquita Petra H M Peeters Antonia Trichopoulou Jakob Linseisen Heiner Boeing Göran Hallmans Kim Overvad Anne Tjønneland Merethe Kumle Elio Riboli Kristjan Välk Tõnu Vooder Tõnu Voodern Andres Metspalu Diana Zelenika Anne Boland Marc Delepine Mario Foglio Doris Lechner Hélène Blanché Ivo G Gut Pilar Galan Simon Heath Mia Hashibe Richard B Hayes Paolo Boffetta Mark Lathrop Paul Brennan

PLoS Genet 2011 Mar 17;7(3):e1001333. Epub 2011 Mar 17.

International Agency for Research on Cancer (IARC), Lyon, France.

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March 2011

Branchiogenic carcinoma of a first branchial cleft cyst.

Otolaryngol Head Neck Surg 2010 Jul 24;143(1):167-8, 168.e1. Epub 2010 Apr 24.

Department of Otolaryngology-Head and Neck Surgery, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

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July 2010

Epstein-Barr virus latent membrane protein 1 is not associated with vessel density nor with hypoxia inducible factor 1 alpha expression in nasopharyngeal carcinoma tissue.

Head Neck Pathol 2009 Dec 12;3(4):276-82. Epub 2009 Nov 12.

Department of Pathology and Laboratory Medicine, The Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, 27599-7525, USA.

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December 2009

NF-kB and Bcl-3 activation are prognostic in metastatic colorectal cancer.

Oncology 2010 23;78(3-4):181-8. Epub 2010 Apr 23.

Department of Internal Medicine, Lineberger Comprehensive Cancer Center, Chapel Hill, NC 27599-7305, USA.

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July 2010

KRAS mutation detection: a new look at an old gene.

Clin Chem 2010 May 5;56(5):698-701. Epub 2010 Mar 5.

Molecular Pathology and Translational Research Program, Department of Pathology, Dartmouth Medical School, Dartmouth-Hitchcock Medical Center, Lebanon, NH, USA.

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May 2010

A firm nodule on the great toe of a 13-year-old boy.

Pediatr Dermatol 2009 Nov-Dec;26(6):747-8

Departments of Dermatology, University of North Carolina School of Medicine, Chapel Hill, North Carolina 27514, USA.

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June 2010

Oral health and risk for head and neck squamous cell carcinoma: the Carolina Head and Neck Cancer Study.

Cancer Causes Control 2010 Apr 5;21(4):567-75. Epub 2010 Jan 5.

Department of Epidemiology, CB#7435, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC 27599-7435, USA.

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April 2010

Simultaneous FDG PET+/Glut1+ lung and FDG PET-/Glut1- subcarinal lymph node metastases from prostate cancer.

Ann Nucl Med 2009 Aug 13;23(6):595-7. Epub 2009 May 13.

Section of Nuclear Medicine, Department of Radiology, UNC School of Medicine, Chapel Hill, NC 27599-7510, USA.

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August 2009

Novel critical role of Toll-like receptor 4 in lung ischemia-reperfusion injury and edema.

Am J Physiol Lung Cell Mol Physiol 2009 Jul 17;297(1):L52-63. Epub 2009 Apr 17.

Division of Cardiothoracic Surgery, Cystic Fibrosis Pulmonary Research and Treatment Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599-7065, USA.

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July 2009

Molecular discrimination of multiple primary versus metastatic squamous cell cancers of the head/neck and lung.

Exp Mol Pathol 2009 Feb 27;86(1):1-9. Epub 2008 Nov 27.

Department of Pathology and Laboratory Medicine, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA.

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February 2009

Expression of nuclear factor-kappaB family proteins in hepatocellular carcinomas.

Oncology 2007 15;72(1-2):97-104. Epub 2007 Nov 15.

Department of Medicine, Division of Hematology and Oncology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.

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January 2008

In vivo response to vascular injury in the absence of factor IX: examination in factor IX knockout mice.

Thromb Res 2007 9;121(2):225-34. Epub 2007 May 9.

Department of Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

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March 2008

Detection of pre-invasive lung cancer: technical aspects of the LIFE project.

Toxicol Pathol 2007 Jan;35(1):65-74

Laboratory of Experimental Pathology, National Institute of Environmental Sciences, NIH, Research Triangle Park, NC 27709, USA.

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January 2007

Ex-vivo perfusion and ventilation of rat lungs from non-heart-beating donors before transplant.

Ann Thorac Surg 2006 Oct;82(4):1219-25

Department of Cancer and Thoracic Surgery, Okayama University Graduate School of Medicine and Dentistry, Okayama, Japan.

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October 2006

Pulmonary immune responses to Propionibacterium acnes in C57BL/6 and BALB/c mice.

Am J Respir Cell Mol Biol 2006 Sep 27;35(3):347-56. Epub 2006 Apr 27.

Department of Medicine, Division of Pulmonary Diseases and Cricital Care Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599-7219, USA.

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September 2006

Plasma cell (Zoon's) balanitis with concomitant HIV infection.

Urology 2005 Sep;66(3):657

Division of Urology, Department of Surgery, University of North Carolina School of Medicine, Chapel Hill, North Carolina 27599, USA.

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September 2005

Microsatellite instability testing in colorectal carcinoma: choice of markers affects sensitivity of detection of mismatch repair-deficient tumors.

Clin Cancer Res 2005 Mar;11(6):2180-7

Curriculum in Genetics and Molecular Biology, Department of Genetics, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.

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March 2005

The expression of the SWI/SNF ATPase subunits BRG1 and BRM in normal human tissues.

Appl Immunohistochem Mol Morphol 2005 Mar;13(1):66-74

Division of Hematology/Oncology, University of Michigan, Ann Arbor, Michigan, USA.

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March 2005

Evidence of pluripotent human prostate stem cells in a human prostate primary xenograft model.

Prostate 2004 Jul;60(2):77-90

Department of Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill, North Carolina 27599, USA.

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July 2004

Bronchial margins in lung cancer resection specimens: utility of frozen section and gross evaluation.

Mod Pathol 2004 Sep;17(9):1080-6

Department of Pathology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

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September 2004

Short-term human prostate primary xenografts: an in vivo model of human prostate cancer vasculature and angiogenesis.

Cancer Res 2004 Mar;64(5):1712-21

Department of Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill, North Carolina 27599, USA.

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March 2004

Loss of BRG1/BRM in human lung cancer cell lines and primary lung cancers: correlation with poor prognosis.

Cancer Res 2003 Feb;63(3):560-6

Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, 27599-7295, USA.

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February 2003

p16 and p53 Protein expression as prognostic indicators of survival and disease recurrence from head and neck cancer.

Clin Cancer Res 2002 Nov;8(11):3445-53

Department of Epidemiology, School of Public Health, University of North Carolina at Chapel Hill, USA.

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November 2002

Spindle cell lesions of the head and neck mimicking rhabdomyosarcoma in children.

Pediatr Hematol Oncol 2002 Mar;19(2):129-34

Department of Pediatrics, University of North Carolina at Chapel Hill, 27599-7220, USA.

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March 2002