William Jou

William Jou

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William Jou

William Jou

Publications by authors named "William Jou"

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Biphasic effect of melanocortin agonists on metabolic rate and body temperature.

Cell Metab 2014 Aug 26;20(2):333-45. Epub 2014 Jun 26.

Diabetes, Endocrinology, and Obesity Branch, National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, MD 20892, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2014.05.021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4126889PMC
August 2014

A novel experimental strategy to assess the metabolic effects of selective activation of a G(q)-coupled receptor in hepatocytes in vivo.

Endocrinology 2013 Oct 16;154(10):3539-51. Epub 2013 Jul 16.

PhD, Chief, Molecular Signaling Section, Laboratory of Bioorganic Chemistry, National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases, Building 8A, Room B1A-05, 8 Center Drive MSC 0810, Bethesda, Maryland 20892-0810. or Jianhua Li, PhD, Center for Molecular Medicine, National Institutes of Health, National Heart, Lung, and Blood Institute, Building 10-CRC, Room 5-3216, 10 Center Drive MSC 1454, Bethesda, Maryland 20892-1454. E-mail:

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http://dx.doi.org/10.1210/en.2012-2127DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3776870PMC
October 2013

Myostatin inhibition prevents diabetes and hyperphagia in a mouse model of lipodystrophy.

Diabetes 2012 Oct 17;61(10):2414-23. Epub 2012 May 17.

Genetics of Development and Disease Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, USA.

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http://dx.doi.org/10.2337/db11-0915DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3447905PMC
October 2012

Spinophilin as a novel regulator of M3 muscarinic receptor-mediated insulin release in vitro and in vivo.

FASEB J 2012 Oct 22;26(10):4275-86. Epub 2012 Jun 22.

Molecular Signaling Section, Mouse Metabolic Core Facility, Laboratory of Bioorganic Chemistry, NIH-NIDDK, Bldg. 8A, Rm. B1A-05, 8 Center Dr. MSC 0810 Bethesda, MD 20892-0810, USA.

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http://www.fasebj.org/doi/10.1096/fj.12-204644
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http://dx.doi.org/10.1096/fj.12-204644DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3448777PMC
October 2012

Suppression of the C/EBP family of transcription factors in adipose tissue causes lipodystrophy.

J Mol Endocrinol 2011 Jun 15;46(3):175-92. Epub 2011 Apr 15.

Laboratory of Metabolism, National Cancer Institute, National Institutes of Health, Building 37, Room 3128, Bethesda, Maryland 20892, USA.

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http://dx.doi.org/10.1530/JME-10-0172DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3159190PMC
June 2011

Beneficial metabolic effects caused by persistent activation of beta-cell M3 muscarinic acetylcholine receptors in transgenic mice.

Endocrinology 2010 Nov 15;151(11):5185-94. Epub 2010 Sep 15.

Molecular Signaling Section, Laboratory of Bioorganic Chemistry, National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases, 8 Center Drive MSC 0810, Bethesda, MD 20892-0810, USA.

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https://academic.oup.com/endo/article-lookup/doi/10.1210/en.
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http://dx.doi.org/10.1210/en.2010-0519DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2954720PMC
November 2010

SIRT6 deficiency results in severe hypoglycemia by enhancing both basal and insulin-stimulated glucose uptake in mice.

J Biol Chem 2010 Nov 16;285(47):36776-84. Epub 2010 Sep 16.

Genetics of Development and Diseases Branch, NIDDK, National Institutes of Health, Bethesda, Maryland 20892, USA.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M110.168039
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http://dx.doi.org/10.1074/jbc.M110.168039DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2978606PMC
November 2010

RGS4 is a negative regulator of insulin release from pancreatic beta-cells in vitro and in vivo.

Proc Natl Acad Sci U S A 2010 Apr 12;107(17):7999-8004. Epub 2010 Apr 12.

Molecular Signaling Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1073/pnas.1003655107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2867926PMC
April 2010

Hepatic muscarinic acetylcholine receptors are not critically involved in maintaining glucose homeostasis in mice.

Diabetes 2009 Dec 14;58(12):2776-87. Epub 2009 Sep 14.

Molecular Signaling Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, USA.

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http://diabetes.diabetesjournals.org/content/early/2009/09/1
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http://diabetes.diabetesjournals.org/cgi/doi/10.2337/db09-05
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http://dx.doi.org/10.2337/db09-0522DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2780871PMC
December 2009

Persistent diet-induced obesity in male C57BL/6 mice resulting from temporary obesigenic diets.

PLoS One 2009 29;4(4):e5370. Epub 2009 Apr 29.

Laboratory of Biological Modeling, National Institute of Diabetes & Digestive & Kidney Diseases, National Institutes of Health, Bethesda, Maryland, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0005370PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2670508PMC
July 2009

Myostatin inhibition in muscle, but not adipose tissue, decreases fat mass and improves insulin sensitivity.

PLoS One 2009 19;4(3):e4937. Epub 2009 Mar 19.

Genetics of Development and Disease Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0004937PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2654157PMC
May 2009

Transduction of rat pancreatic islets with pseudotyped adeno-associated virus vectors.

Virol J 2009 May 18;6:61. Epub 2009 May 18.

Laboratory of Molecular and Cellular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892, USA.

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http://dx.doi.org/10.1186/1743-422X-6-61DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2687429PMC
May 2009

G(s)alpha deficiency in skeletal muscle leads to reduced muscle mass, fiber-type switching, and glucose intolerance without insulin resistance or deficiency.

Am J Physiol Cell Physiol 2009 Apr 21;296(4):C930-40. Epub 2009 Jan 21.

Metabolic Diseases Branch, National Institute of Diabetes, Digestive, and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892-1752, USA.

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http://dx.doi.org/10.1152/ajpcell.00443.2008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2670650PMC
April 2009

Hypertrophy and/or Hyperplasia: Dynamics of Adipose Tissue Growth.

PLoS Comput Biol 2009 Mar 27;5(3):e1000324. Epub 2009 Mar 27.

Laboratory of Biological Modeling, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethedsa, Maryland, USA.

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http://dx.doi.org/10.1371/journal.pcbi.1000324DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2653640PMC
March 2009

Beneficial metabolic effects of M3 muscarinic acetylcholine receptor deficiency.

Cell Metab 2006 Nov;4(5):363-75

Molecular Signaling Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, Maryland 20892, USA.

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http://dx.doi.org/10.1016/j.cmet.2006.09.008DOI Listing
November 2006

Recombinant human insulin-like growth factor-I treatment inhibits gluconeogenesis in a transgenic mouse model of type 2 diabetes mellitus.

Endocrinology 2006 Jun 2;147(6):2619-30. Epub 2006 Mar 2.

Diabetes Branch, National Institute of Diabetes and Digestive and Kidney Diseases, Betheda, MD 20892, USA.

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http://dx.doi.org/10.1210/en.2005-1556DOI Listing
June 2006

Effect of adipocyte beta3-adrenergic receptor activation on the type 2 diabetic MKR mice.

Am J Physiol Endocrinol Metab 2006 Jun;290(6):E1227-36

Diabetes Branch, National Institute of Diabetes, Digestive and Kidney Diseases, NIH, Bethesda, MD, USA.

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http://dx.doi.org/10.1152/ajpendo.00344.2005DOI Listing
June 2006

Leptin improves insulin resistance and hyperglycemia in a mouse model of type 2 diabetes.

Endocrinology 2005 Sep 9;146(9):4024-35. Epub 2005 Jun 9.

Diabetes Branch, National Institute of Diabetes and Digestive and Kidney Diseases, Room 8D12, Building 10, MSC 1758, National Institutes of Health, Bethesda, Maryland 20892-1758, USA.

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https://academic.oup.com/endo/article-lookup/doi/10.1210/en.
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http://dx.doi.org/10.1210/en.2005-0087DOI Listing
September 2005

Phloridzin improves hyperglycemia but not hepatic insulin resistance in a transgenic mouse model of type 2 diabetes.

Diabetes 2004 Nov;53(11):2901-9

Diabetes Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892-1758, USA.

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http://dx.doi.org/10.2337/diabetes.53.11.2901DOI Listing
November 2004

Muscle-specific overexpression of CD36 reverses the insulin resistance and diabetes of MKR mice.

Endocrinology 2004 Oct 1;145(10):4667-76. Epub 2004 Jul 1.

Diabetes Branch, NIDDK, Room 8D12, Building 10, National Institutes of Health, Bethesda, Maryland 20892-1758, USA.

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http://dx.doi.org/10.1210/en.2003-1543DOI Listing
October 2004