William Jagust

William Jagust

UNVERIFIED PROFILE

Are you William Jagust?   Register this Author

Register author
William Jagust

William Jagust

Publications by authors named "William Jagust"

Are you William Jagust?   Register this Author

100Publications

3153Reads

27Profile Views

What are the threats to successful brain and cognitive aging?

Neurobiol Aging 2019 Nov;83:130-134

Laboratory of Behavioral Neuroscience, National Institute on Aging, Baltimore, MD, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.neurobiolaging.2019.04.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6859944PMC
November 2019

Effect of Off-Target Binding on F-Flortaucipir Variability in Healthy Controls Across the Life Span.

J Nucl Med 2019 Oct 15;60(10):1444-1451. Epub 2019 Mar 15.

Lawrence Berkeley National Laboratory, Berkeley, California.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2967/jnumed.118.224113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6785795PMC
October 2019

Tau deposition is associated with functional isolation of the hippocampus in aging.

Nat Commun 2019 Oct 25;10(1):4900. Epub 2019 Oct 25.

Helen Wills Neuroscience Institute, UC Berkeley, Berkeley, CA, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41467-019-12921-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6814780PMC
October 2019

Tau PET and multimodal brain imaging in patients at risk for chronic traumatic encephalopathy.

Neuroimage Clin 2019 Oct 17;24:102025. Epub 2019 Oct 17.

Memory and Aging Center, Department of Neurology, Weill Institute for Neurosciences, University of California, San Francisco, CA, 94158, United States; Departments of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA 94158, United States; Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, United States; Helen Wills Neuroscience Institute, University of California Berkeley, Berkeley, CA 94720, United States.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.nicl.2019.102025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6831941PMC
October 2019

Cortical tau deposition follows patterns of entorhinal functional connectivity in aging.

Elife 2019 09 2;8. Epub 2019 Sep 2.

Helen Wills Neuroscience Institute, UC Berkeley, Berkeley, United States.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.7554/eLife.49132DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6764824PMC
September 2019

Sleep as a Potential Biomarker of Tau and β-Amyloid Burden in the Human Brain.

J Neurosci 2019 Aug 17;39(32):6315-6324. Epub 2019 Jun 17.

Center for Human Sleep Science, Department of Psychology, University of California Berkeley, Berkeley, California 94720,

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1523/JNEUROSCI.0503-19.2019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6687908PMC
August 2019

Development of a mnemonic discrimination task using naturalistic stimuli with applications to aging and preclinical Alzheimer's disease.

Learn Mem 2019 Jul 17;26(7):219-228. Epub 2019 Jun 17.

Helen Wills Neuroscience Institute, University of California, Berkeley, Berkeley, California 94720, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1101/lm.048967.118DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6581010PMC
July 2019

Biomarkers for tau pathology.

Mol Cell Neurosci 2019 Jun 7;97:18-33. Epub 2018 Dec 7.

Helen Wills Neuroscience Institute, University of California, Berkeley, USA; Molecular Biophysics and Integrated Bioimaging, Lawrence Berkeley National Laboratory, Berkeley, CA, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.mcn.2018.12.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6584358PMC
June 2019

Age-related variability in decision-making: Insights from neurochemistry.

Cogn Affect Behav Neurosci 2019 Jun;19(3):415-434

Helen Wills Neuroscience Institute, University of California Berkeley, Berkeley, CA, 94720, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3758/s13415-018-00678-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6684213PMC
June 2019

Relationships Between Tau and Glucose Metabolism Reflect Alzheimer's Disease Pathology in Cognitively Normal Older Adults.

Cereb Cortex 2019 May;29(5):1997-2009

Helen Wills Neuroscience Institute, University of California, Berkeley, CA, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/cercor/bhy078DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6458898PMC
May 2019

Tau covariance patterns in Alzheimer's disease patients match intrinsic connectivity networks in the healthy brain.

Neuroimage Clin 2019 2;23:101848. Epub 2019 May 2.

Memory and Aging Center, University of California San Francisco, San Francisco, CA 94143, USA; Helen Wills Neuroscience Institute, University of California Berkeley, Berkeley, CA 94720, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.nicl.2019.101848DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6510968PMC
May 2019

Dopaminergic Mechanisms Underlying Normal Variation in Trait Anxiety.

J Neurosci 2019 Apr 8;39(14):2735-2744. Epub 2019 Feb 8.

Lawrence Berkeley National Laboratory, Berkeley, California 94720, and.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1523/JNEUROSCI.2382-18.2019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6445999PMC
April 2019

Metabolic brain networks in aging and preclinical Alzheimer's disease.

Neuroimage Clin 2018 28;17:987-999. Epub 2017 Dec 28.

Helen Wills Neuroscience Institute, University of California Berkeley, Berkeley, CA, United States.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.nicl.2017.12.037DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5842784PMC
January 2019

Understanding disease progression and improving Alzheimer's disease clinical trials: Recent highlights from the Alzheimer's Disease Neuroimaging Initiative.

Alzheimers Dement 2019 01 13;15(1):106-152. Epub 2018 Oct 13.

Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Institute on Aging, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Alzheimer's Disease Core Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Udall Parkinson's Research Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jalz.2018.08.005DOI Listing
January 2019

Imaging the evolution and pathophysiology of Alzheimer disease.

Authors:
William Jagust

Nat Rev Neurosci 2018 11;19(11):687-700

Helen Wills Neuroscience Institute, University of California, Berkeley, CA, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41583-018-0067-3DOI Listing
November 2018

A New Tool for Clinical Neuroscience-Synaptic Imaging.

JAMA Neurol 2018 10;75(10):1181-1183

Helen Wills Neuroscience Institute, University of California, Berkeley, Berkeley.

View Article

Download full-text PDF

Source
http://archneur.jamanetwork.com/article.aspx?doi=10.1001/jam
Publisher Site
http://dx.doi.org/10.1001/jamaneurol.2018.1643DOI Listing
October 2018

Prevalence of the apolipoprotein E ε4 allele in amyloid β positive subjects across the spectrum of Alzheimer's disease.

Authors:
Niklas Mattsson Colin Groot Willemijn J Jansen Susan M Landau Victor L Villemagne Sebastiaan Engelborghs Mark M Mintun Alberto Lleo José Luis Molinuevo William J Jagust Giovanni B Frisoni Adrian Ivanoiu Gaël Chételat Catarina Resende de Oliveira Karen M Rodrigue Johannes Kornhuber Anders Wallin Aleksandra Klimkowicz-Mrowiec Ramesh Kandimalla Julius Popp Pauline P Aalten Dag Aarsland Daniel Alcolea Ina S Almdahl Inês Baldeiras Mark A van Buchem Enrica Cavedo Kewei Chen Ann D Cohen Stefan Förster Juan Fortea Kristian S Frederiksen Yvonne Freund-Levi Kiran Dip Gill Olymbia Gkatzima Timo Grimmer Harald Hampel Sanna-Kaisa Herukka Peter Johannsen Koen van Laere Mony J de Leon Wolfgang Maier Jan Marcusson Olga Meulenbroek Hanne M Møllergård John C Morris Barbara Mroczko Arto Nordlund Sudesh Prabhakar Oliver Peters Lorena Rami Eloy Rodríguez-Rodríguez Catherine M Roe Eckart Rüther Isabel Santana Johannes Schröder Sang W Seo Hilkka Soininen Luiza Spiru Erik Stomrud Hanne Struyfs Charlotte E Teunissen Frans R J Verhey Stephanie J B Vos Linda J C van Waalwijk van Doorn Gunhild Waldemar Åsa K Wallin Jens Wiltfang Rik Vandenberghe David J Brooks Tormod Fladby Christopher C Rowe Alexander Drzezga Marcel M Verbeek Marie Sarazin David A Wolk Adam S Fleisher William E Klunk Duk L Na Pascual Sánchez-Juan Dong Young Lee Agneta Nordberg Magda Tsolaki Vincent Camus Juha O Rinne Anne M Fagan Henrik Zetterberg Kaj Blennow Gil D Rabinovici Oskar Hansson Bart N M van Berckel Wiesje M van der Flier Philip Scheltens Pieter Jelle Visser Rik Ossenkoppele

Alzheimers Dement 2018 07 28;14(7):913-924. Epub 2018 Mar 28.

Clinical Memory Research Unit, Clinical Sciences Malmö, Lund University, Lund, Sweden; Department of Neurology and Alzheimer Center, VU University Medical Center, Neuroscience Campus Amsterdam, Amsterdam, the Netherlands; Department of Radiology and Nuclear Medicine, VU University Medical Center, Neuroscience Campus Amsterdam, Amsterdam, the Netherlands. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jalz.2018.02.009DOI Listing
July 2018

Brain morphology, cognition, and β-amyloid in older adults with superior memory performance.

Neurobiol Aging 2018 07 27;67:162-170. Epub 2018 Mar 27.

Helen Wills Neuroscience Institute, UC Berkeley, Berkeley, CA, USA; Lawrence Berkeley National Laboratory, Berkeley, CA, USA.

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S01974580183010
Publisher Site
http://dx.doi.org/10.1016/j.neurobiolaging.2018.03.024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5955827PMC
July 2018

Increased Striatal Dopamine Synthesis Capacity in Gambling Addiction.

Biol Psychiatry 2018 06 16;83(12):1036-1043. Epub 2017 Jun 16.

Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, The Netherlands; Department of Psychiatry, Radboud University Medical Center, Nijmegen, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.biopsych.2017.06.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6698370PMC
June 2018

Two Novel Mutations in the First Transmembrane Domain of Presenilin1 Cause Young-Onset Alzheimer's Disease.

J Alzheimers Dis 2017 ;58(4):1035-1041

Alzheimer's Disease Research Center, Keck School of Medicine at the University of Southern California, Los Angeles, CA, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3233/JAD-161203DOI Listing
May 2018

Spontaneous eye blink rate and dopamine synthesis capacity: preliminary evidence for an absence of positive correlation.

Eur J Neurosci 2018 05 26;47(9):1081-1086. Epub 2018 Mar 26.

Donders Institute for Brain, Cognition and Behaviour, Donders Centre for Cognitive Neuroimaging, Radboud University, PO Box 9101, Nijmegen, 6500 HB, The Netherlands.

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1111/ejn.13895
Publisher Site
http://dx.doi.org/10.1111/ejn.13895DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5969266PMC
May 2018

Subthreshold Amyloid Predicts Tau Deposition in Aging.

J Neurosci 2018 05 23;38(19):4482-4489. Epub 2018 Apr 23.

Helen Wills Neuroscience Institute, University of California, Berkeley, California 94720.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1523/JNEUROSCI.0485-18.2018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5943976PMC
May 2018

Memory decline accompanies subthreshold amyloid accumulation.

Neurology 2018 04 23;90(17):e1452-e1460. Epub 2018 Mar 23.

From Helen Wills Neuroscience Institute, University of California; and Molecular Biophysics and Integrated Bioimaging, Lawrence Berkeley National Laboratory, Berkeley, CA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1212/WNL.0000000000005354DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5921038PMC
April 2018

Head to head comparison of [F] AV-1451 and [F] THK5351 for tau imaging in Alzheimer's disease and frontotemporal dementia.

Eur J Nucl Med Mol Imaging 2018 03 16;45(3):432-442. Epub 2017 Nov 16.

Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-ro, Kangnam-ku, Seoul, 06351, South Korea.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00259-017-3876-0DOI Listing
March 2018

Following the pathway to Alzheimer's disease.

Authors:
William Jagust

Nat Neurosci 2018 03;21(3):306-308

Helen Wills Neuroscience Institute, University of California, Berkeley, Berkeley, California, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41593-018-0085-5DOI Listing
March 2018

Association of Cerebral Amyloid-β Aggregation With Cognitive Functioning in Persons Without Dementia.

Authors:
Willemijn J Jansen Rik Ossenkoppele Betty M Tijms Anne M Fagan Oskar Hansson William E Klunk Wiesje M van der Flier Victor L Villemagne Giovanni B Frisoni Adam S Fleisher Alberto Lleó Mark A Mintun Anders Wallin Sebastiaan Engelborghs Duk L Na Gäel Chételat José Luis Molinuevo Susan M Landau Niklas Mattsson Johannes Kornhuber Osama Sabri Christopher C Rowe Lucilla Parnetti Julius Popp Tormod Fladby William J Jagust Pauline Aalten Dong Young Lee Rik Vandenberghe Catarina Resende de Oliveira Elisabeth Kapaki Lutz Froelich Adrian Ivanoiu Tomasz Gabryelewicz Marcel M Verbeek Páscual Sanchez-Juan Helmut Hildebrandt Vincent Camus Marzena Zboch David J Brooks Alexander Drzezga Juha O Rinne Andrew Newberg Alexandre de Mendonça Marie Sarazin Gil D Rabinovici Karine Madsen Milica G Kramberger Agneta Nordberg Vincent Mok Barbara Mroczko David A Wolk Philipp T Meyer Magda Tsolaki Philip Scheltens Frans R J Verhey Pieter Jelle Visser Dag Aarsland Daniel Alcolea Myriam Alexander Ina S Almdahl Steven E Arnold Inês Baldeiras Henryk Barthel Bart N M van Berckel Kaj Blennow Mark A van Buchem Enrica Cavedo Kewei Chen Elena Chipi Ann D Cohen Stefan Förster Juan Fortea Kristian S Frederiksen Yvonne Freund-Levi Olymbia Gkatzima Mark Forrest Gordon Timo Grimmer Harald Hampel Lucrezia Hausner Sabine Hellwig Sanna-Kaisa Herukka Peter Johannsen Aleksandra Klimkowicz-Mrowiec Sebastian Köhler Norman Koglin Koen van Laere Mony de Leon Viviana Lisetti Wolfgang Maier Jan Marcusson Olga Meulenbroek Hanne M Møllergård John C Morris Arto Nordlund Gerald P Novak George P Paraskevas Gayan Perera Oliver Peters Inez H G B Ramakers Lorena Rami Eloy Rodríguez-Rodríguez Catherine M Roe Uros Rot Eckart Rüther Isabel Santana Johannes Schröder Sang W Seo Hilkka Soininen Luiza Spiru Erik Stomrud Hanne Struyfs Charlotte E Teunissen Stephanie J B Vos Linda J C van Waalwijk van Doorn Gunhild Waldemar Åsa K Wallin Jens Wiltfang Henrik Zetterberg

JAMA Psychiatry 2018 01;75(1):84-95

Institute of Neuroscience and Physiology, Sahlgrenska Academy at University of Gothenburg, Mölndal, Sweden.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1001/jamapsychiatry.2017.3391DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5786156PMC
January 2018

Entorhinal Tau Pathology, Episodic Memory Decline, and Neurodegeneration in Aging.

J Neurosci 2018 01 30;38(3):530-543. Epub 2017 Nov 30.

Helen Wills Neuroscience Institute, University of California Berkeley, Berkeley, California 94720.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1523/JNEUROSCI.2028-17.2017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5777108PMC
January 2018

Old Brains Come Uncoupled in Sleep: Slow Wave-Spindle Synchrony, Brain Atrophy, and Forgetting.

Neuron 2018 01 14;97(1):221-230.e4. Epub 2017 Dec 14.

Helen Wills Neuroscience Institute, UC Berkeley, 132 Barker Hall, Berkeley, CA 94720, USA; Department of Psychology, UC Berkeley, Tolman Hall, Berkeley, CA 94720, USA.

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S08966273173107
Publisher Site
http://dx.doi.org/10.1016/j.neuron.2017.11.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5754239PMC
January 2018

Associations between [F]AV1451 tau PET and CSF measures of tau pathology in a clinical sample.

Neurology 2018 01 27;90(4):e282-e290. Epub 2017 Dec 27.

From the Memory and Aging Center (R.L.J., A.B., N.A., V.B., A.L.B., J.C., A.K., A.M., Z.A.M., J.P., H.J.R., R.T., A.V., B.L.M., G.D.R.), University of California San Francisco; Knight Alzheimer's Disease Research Center (A.M.F., G.J.), Department of Neurology (A.M.F., G.J.), and The Hope Center for Neurological Disorders (A.M.F., G.J.), Washington University in St. Louis, MO; Molecular Biophysics and Integrated Bioimaging Division (S.L.B., J.P.O., W.J.J.), Lawrence Berkeley National Laboratory, Berkeley, CA; and Helen Wills Neuroscience Institute (A.M., W.J.J., G.D.R.), University of California Berkeley.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1212/WNL.0000000000004860DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5798657PMC
January 2018

The Complexity of Subjective Cognitive Decline.

JAMA Neurol 2017 12;74(12):1400-1402

Helen Wills Neuroscience Institute, University of California, Berkeley.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1001/jamaneurol.2017.2224DOI Listing
December 2017

Considerations and code for partial volume correcting [F]-AV-1451 tau PET data.

Data Brief 2017 Dec 16;15:648-657. Epub 2017 Oct 16.

Molecular Biophysics and Integrated Bioimaging, Lawrence Berkeley National Laboratory, Berkeley, CA, United States.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.dib.2017.10.024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5671473PMC
December 2017

Regional correlations between [C]PIB PET and post-mortem burden of amyloid-beta pathology in a diverse neuropathological cohort.

Neuroimage Clin 2017 11;13:130-137. Epub 2016 Nov 11.

Memory and Aging Center, Department of Neurology, University of California, San Francisco, USA; Helen Wills Neuroscience Institute, University of California, Berkeley, USA; Lawrence Berkeley National Laboratory, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.nicl.2016.11.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5144753PMC
November 2017

Subjective cognitive decline and β-amyloid burden predict cognitive change in healthy elderly.

Neurology 2017 Nov 6;89(19):2002-2009. Epub 2017 Oct 6.

From Helen Wills Neuroscience Institute (J.W.V., M.V.D., R.L.J., S.M.M., H.D.S., S.M.L., W.J.J.), University of California, Berkeley; and Memory and Aging Center (R.L.J.), University of California, San Francisco.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1212/WNL.0000000000004627DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5679415PMC
November 2017

Comparison of multiple tau-PET measures as biomarkers in aging and Alzheimer's disease.

Neuroimage 2017 08 3;157:448-463. Epub 2017 Jun 3.

Helen Wills Neuroscience Institute, University of California, Berkeley, Berkeley, CA, United States; Molecular Biophysics and Integrated Bioimaging, Lawrence Berkeley National Lab, Berkeley, CA, United States; Memory and Aging Center, University of California San Francisco, San Francisco, CA, United States. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.neuroimage.2017.05.058DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5814575PMC
August 2017

Alzheimer Disease Signature Neurodegeneration and APOE Genotype in Mild Cognitive Impairment With Suspected Non-Alzheimer Disease Pathophysiology.

JAMA Neurol 2017 06;74(6):650-659

Helen Wills Neuroscience Institute, University of California, Berkeley6Molecular Biophysics and Integrated Bioimaging Division, Lawrence Berkeley National Laboratory, Berkeley, California.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1001/jamaneurol.2016.5349DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5822210PMC
June 2017

The Alzheimer's Disease Neuroimaging Initiative 3: Continued innovation for clinical trial improvement.

Alzheimers Dement 2017 May 5;13(5):561-571. Epub 2016 Dec 5.

Institute on Aging, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Alzheimer's Disease Core Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Udall Parkinson's Research Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Department of Pathology and Laboratory Medicine, Center for Neurodegenerative Research, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jalz.2016.10.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5536850PMC
May 2017

Association between tau deposition and antecedent amyloid-β accumulation rates in normal and early symptomatic individuals.

Brain 2017 May;140(5):1499-1512

Department of Radiology and Biomedical Imaging, University of California - San Francisco, San Francisco, CA, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/brain/awx046DOI Listing
May 2017

Amyloid and tau PET demonstrate region-specific associations in normal older people.

Neuroimage 2017 04 21;150:191-199. Epub 2017 Feb 21.

Helen Wills Neuroscience Institute, University of California Berkeley, Berkeley, CA 94720, USA; Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.neuroimage.2017.02.051DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5391247PMC
April 2017

Recent publications from the Alzheimer's Disease Neuroimaging Initiative: Reviewing progress toward improved AD clinical trials.

Alzheimers Dement 2017 Apr 22;13(4):e1-e85. Epub 2017 Mar 22.

Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Institute on Aging, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Alzheimer's Disease Core Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Udall Parkinson's Research Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jalz.2016.11.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6818723PMC
April 2017

Elevated F-AV-1451 PET tracer uptake detected in incidental imaging findings.

Neurology 2017 03 10;88(11):1095-1097. Epub 2017 Feb 10.

From the University of California, Berkeley (S.N.L., J.R.W., W.J.J.); and the University of California, San Francisco (N.A., R.L.J., G.D.R.).

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1212/WNL.0000000000003724DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5384840PMC
March 2017

Tau and β-Amyloid Are Associated with Medial Temporal Lobe Structure, Function, and Memory Encoding in Normal Aging.

J Neurosci 2017 03 17;37(12):3192-3201. Epub 2017 Feb 17.

Helen Wills Neuroscience Institute, University of California, Berkeley, California 94720, and.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1523/JNEUROSCI.3769-16.2017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5373113PMC
March 2017

Reference Tissue-Based Kinetic Evaluation of 18F-AV-1451 for Tau Imaging.

J Nucl Med 2017 02 1;58(2):332-338. Epub 2016 Sep 1.

Molecular Biophysics and Integrated Bioimaging, Lawrence Berkeley National Lab, Berkeley, California.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2967/jnumed.116.175273DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5288744PMC
February 2017

Frontotemporal dementia with the V337M mutation: Tau-PET and pathology correlations.

Neurology 2017 Feb 27;88(8):758-766. Epub 2017 Jan 27.

From the Memory and Aging Center (S.S., D.R.S., W.W.S., R.O., A.L., H.J.R., A.L.B., D.C.P., B.L.M., G.D.R.), Department of Neurology, and Department of Pathology (W.W.S), University of California, San Francisco; Department of Neurology (B.F.B., J.E.P.), Mayo Clinic, Rochester, MN; Helen Wills Neuroscience Institute (R.O., W.J.J., G.D.R.), University of California Berkeley; Alzheimercenter (R.O.), VU University Medical Center, Amsterdam, the Netherlands; Lawrence Berkeley National Laboratory (J.P.O., W.J.J., M.E.M., G.D.R.), Berkeley, CA; and Department of Pathology (D.W.D.), Mayo Clinic, Jacksonville, FL.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1212/WNL.0000000000003636DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5344079PMC
February 2017

Hippocampal activation is associated with longitudinal amyloid accumulation and cognitive decline.

Elife 2017 02 8;6. Epub 2017 Feb 8.

Helen Wills Neuroscience Institute, University of California, Berkeley, United States.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.7554/eLife.22978DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5325620PMC
February 2017

Tract-Specific Correlates of Neuropsychological Deficits in Patients with Subcortical Vascular Cognitive Impairment.

J Alzheimers Dis 2016 ;50(4):1125-35

Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3233/JAD-150841DOI Listing
December 2016

Diagnostic utility of ASL-MRI and FDG-PET in the behavioral variant of FTD and AD.

Ann Clin Transl Neurol 2016 10 30;3(10):740-751. Epub 2016 Aug 30.

Memory and Aging Center Department of Neurology University of California San Francisco California.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/acn3.330DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5048385PMC
October 2016

Atrophy, hypometabolism and clinical trajectories in patients with amyloid-negative Alzheimer's disease.

Brain 2016 09 29;139(Pt 9):2528-39. Epub 2016 Jun 29.

7 University of California San Francisco, Memory and Aging Centre, Department of Neurology, San Francisco, CA 94720, USA 9 Helen Wills Neuroscience Institute, University of California, Berkeley, Berkeley CA 94720, USA; Lawrence Berkeley National Laboratory, Berkeley, California, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/brain/aww159DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6276935PMC
September 2016

Tau and β-Amyloid-The Malignant Duo.

Authors:
William Jagust

JAMA Neurol 2016 09;73(9):1049-50

School of Public Health, University of California, Berkley2Helen Wills Neuroscience Institute, University of California, Berkley.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1001/jamaneurol.2016.2481DOI Listing
September 2016

Dynamic relationships between age, amyloid-β deposition, and glucose metabolism link to the regional vulnerability to Alzheimer's disease.

Brain 2016 08 13;139(Pt 8):2275-89. Epub 2016 May 13.

1 Helen Wills Neuroscience Institute, University of California-Berkeley, Berkeley, CA 94720, USA 2 Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/brain/aww108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4958895PMC
August 2016

Sleep: A Novel Mechanistic Pathway, Biomarker, and Treatment Target in the Pathology of Alzheimer's Disease?

Trends Neurosci 2016 08 17;39(8):552-566. Epub 2016 Jun 17.

Sleep and Neuroimaging Laboratory University of California, Berkeley, CA 94720-1650, USA; Helen Wills Neuroscience Institute, University of California, Berkeley, CA 94720-1650, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.tins.2016.05.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4967375PMC
August 2016

A/T/N: An unbiased descriptive classification scheme for Alzheimer disease biomarkers.

Neurology 2016 Aug 1;87(5):539-47. Epub 2016 Jul 1.

From the Departments of Radiology (C.R.J.) and Neurology (D.S.K., R.C.P.), Mayo Clinic, Rochester, MN; Rush Alzheimer's Disease Center (D.A.B.), Rush University Medical Center, Chicago, IL; Clinical Neurochemistry Lab (K.B.), Department of Neuroscience and Physiology, University of Gothenburg, Mölndal Hospital, Sahlgrenska University Hospital, Mölndal, Sweden; Alzheimer's Association (M.C.C.), Chicago, IL; Division of Neurology (H.H.F.), UBC Hospital Clinic for Alzheimer's Disease and Related Disorders, University of British Columbia, Vancouver, Canada; Memory Clinic (G.B.F.), University Hospitals and University of Geneva, Switzerland; IRCCS Fatebenefratelli (G.B.F.), The National Centre for Alzheimer's Disease, Brescia, Italy; Sorbonne Universités (H.H.), Université Pierre et Marie Curie, Paris; Institut de la Mémoire et de la Maladie d'Alzheimer (IM2A) and Institut du Cerveau et de la Moelle épinière (ICM) (H.H.), Département de Neurologie, Hôpital de la Pitié-Salpétrière, Paris, France; Helen Wills Neuroscience Institute (W.J.J.), University of California, Berkeley; Departments of Radiology and Neurology (K.A.J.), Massachusetts General Hospital, Harvard Medical School, Boston; Alzheimer Center and Department of Neurology (P.S.), Vrije Universiteit Amsterdam, the Netherlands; Center for Alzheimer Research and Treatment (R.A.S.), Brigham and Women's Hospital and Massachusetts General Hospital, Harvard Medical School, Boston; Centre des Maladies Cognitives et Comportementales (B.D.), Institut du Cerveau et de la Moelle épinière, Paris; and Université Pierre et Marie Curie-Paris 6 (B.D.), AP-HP, Hôpital de la Salpêtrière, Paris, France.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1212/WNL.0000000000002923DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4970664PMC
August 2016

Early life sets the stage for aging.

Authors:
William J Jagust

Proc Natl Acad Sci U S A 2016 08 19;113(33):9148-50. Epub 2016 Jul 19.

School of Public Health, University of California, Berkeley, CA 94720; Helen Wills Neuroscience Institute, University of California, Berkeley, CA 94720

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1073/pnas.1609720113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4995968PMC
August 2016

Association Between Anticholinergic Medication Use and Cognition, Brain Metabolism, and Brain Atrophy in Cognitively Normal Older Adults.

JAMA Neurol 2016 06;73(6):721-32

Center for Neuroimaging, Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indiana University Health Neuroscience Center, Indianapolis2Indiana Alzheimer Disease Center, Indiana University School of Medicine, Indianapolis.

View Article

Download full-text PDF

Source
http://archneur.jamanetwork.com/article.aspx?doi=10.1001/jam
Publisher Site
http://dx.doi.org/10.1001/jamaneurol.2016.0580DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5029278PMC
June 2016

Accelerating rates of cognitive decline and imaging markers associated with β-amyloid pathology.

Neurology 2016 05 15;86(20):1887-96. Epub 2016 Apr 15.

From the Center for Imaging of Neurodegenerative Diseases (P.S.I., R.S.M., R.L.N., D.T., M.W.W.), Department of Veterans Affairs Medical Center, San Francisco; Departments of Radiology and Biomedical Imaging (P.S.I., D.T., M.W.W.) and Psychiatry (R.S.M.), University of California, San Francisco; Clinical Memory Research Unit, Faculty of Medicine (P.S.I., N.M.), Lund University; Memory Clinic (N.M.) and Department of Neurology (N.M.), Skåne University Hospital, Lund University; MedTech West and the Department of Clinical Neuroscience and Rehabilitation (M.S.), University of Gothenburg, Sweden; Department of Neurology (M.C.D., P.S.A.), Keck School of Medicine, University of Southern California, Los Angeles; Helen Wills Neuroscience Institute (W.J.J.), University of California, Berkeley; and Life Sciences Division (M.S., W.J.J.), Lawrence Berkeley National Laboratory, Berkeley CA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1212/WNL.0000000000002683DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4873684PMC
May 2016

Amyloid negativity in patients with clinically diagnosed Alzheimer disease and MCI.

Neurology 2016 Apr 11;86(15):1377-1385. Epub 2016 Mar 11.

From Helen Wills Neuroscience Institute (S.M.L., A.H., W.J.J.), University of California, Berkeley; and Life Sciences Division (S.M.L., A.F., W.J.J.), Lawrence Berkeley National Laboratory, CA.

View Article

Download full-text PDF

Source
http://www.neurology.org/content/early/2016/03/11/WNL.000000
Web Search
http://www.neurology.org/cgi/doi/10.1212/WNL.000000000000257
Publisher Site
http://dx.doi.org/10.1212/WNL.0000000000002576DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4831042PMC
April 2016

Impact of lifestyle dimensions on brain pathology and cognition.

Neurobiol Aging 2016 Apr 30;40:164-172. Epub 2016 Jan 30.

Helen Wills Neuroscience Institute, University of California, Berkeley, CA, USA; Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.neurobiolaging.2016.01.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4792130PMC
April 2016

Modulation of impulsivity and reward sensitivity in intertemporal choice by striatal and midbrain dopamine synthesis in healthy adults.

J Neurophysiol 2016 Mar 16;115(3):1146-56. Epub 2015 Dec 16.

Neurobiology Curriculum, University of North Carolina, Chapel Hill, North Carolina; Department of Psychology & Neuroscience, Bowles Center for Alcohol Studies, and Biomedical Research Imaging Center, University of North Carolina, Chapel Hill, North Carolina

View Article

Download full-text PDF

Source
http://jn.physiology.org/content/jn/early/2015/12/12/jn.0026
Web Search
http://jn.physiology.org/lookup/doi/10.1152/jn.00261.2015
Publisher Site
http://dx.doi.org/10.1152/jn.00261.2015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4808128PMC
March 2016

Suspected non-Alzheimer disease pathophysiology--concept and controversy.

Nat Rev Neurol 2016 Feb 18;12(2):117-24. Epub 2016 Jan 18.

Department of Psychiatry and Neuropsychology, Institute of Mental Health and Neuroscience, Maastricht University, PO Box 616 MD Maastricht, Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nrneurol.2015.251DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4784257PMC
February 2016

Is amyloid-β harmful to the brain? Insights from human imaging studies.

Authors:
William Jagust

Brain 2016 Jan 27;139(Pt 1):23-30. Epub 2015 Nov 27.

School of Public Health and Helen Wills Neuroscience Institute, University of California, Berkeley, USA

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/brain/awv326DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4990654PMC
January 2016

Regional brain hypometabolism is unrelated to regional amyloid plaque burden.

Brain 2015 Dec 29;138(Pt 12):3734-46. Epub 2015 Sep 29.

1 FIND Lab, Department of Neurology and Neurological Sciences, Stanford University, Stanford California, USA

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/brain/awv278DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4806718PMC
December 2015

Loss of functional connectivity is greater outside the default mode network in nonfamilial early-onset Alzheimer's disease variants.

Neurobiol Aging 2015 Oct 16;36(10):2678-86. Epub 2015 Jul 16.

Department of Neurology, Memory and Aging Center, University of California San Francisco, San Francisco, CA, USA; Helen Wills Neuroscience Institute, University of California Berkeley, Berkeley, CA, USA; Lawrence Berkeley National Laboratory, Life Sciences Division, Berkeley, CA, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.neurobiolaging.2015.06.029DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4698410PMC
October 2015

GWAS of longitudinal amyloid accumulation on 18F-florbetapir PET in Alzheimer's disease implicates microglial activation gene IL1RAP.

Brain 2015 Oct 11;138(Pt 10):3076-88. Epub 2015 Aug 11.

1 Centre for Neuroimaging, Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN 46202, USA 1 Centre for Neuroimaging, Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN 46202, USA 4 Indiana Alzheimer Disease Centre, Indiana University School of Medicine, Indianapolis, IN 46202, USA 5 Centre for Computational Biology and Bioinformatics, Indiana University School of Medicine, Indianapolis, IN 46202, USA

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/brain/awv231DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4671479PMC
October 2015

Comparison of Visual and Quantitative Florbetapir F 18 Positron Emission Tomography Analysis in Predicting Mild Cognitive Impairment Outcomes.

JAMA Neurol 2015 Oct;72(10):1183-90

Helen Wills Neuroscience Institute, University of California, Berkeley4Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California.

View Article

Download full-text PDF

Source
http://archneur.jamanetwork.com/data/Journals/NEUR/934568/no
Web Search
http://archneur.jamanetwork.com/article.aspx?doi=10.1001/jam
Publisher Site
http://dx.doi.org/10.1001/jamaneurol.2015.1633DOI Listing
October 2015

Alzheimer risk genes modulate the relationship between plasma apoE and cortical PiB binding.

Neurol Genet 2015 Oct 15;1(3):e22. Epub 2015 Oct 15.

University of California Berkeley (A.L.), Berkeley; Oakland University William Beaumont School of Medicine (K.S.H.), Rochester, MI; Department of Neurology (K.S.H., N.G., A.E.B., E.T., G.C., L.G.A.), David Geffen School of Medicine at UCLA, Los Angeles, CA; Drexel University College of Medicine (L.M.R.), Philadelphia, PA; Northwestern University Feinberg School of Medicine (J.E.), Chicago, IL; Veterans Affairs Greater Los Angeles Healthcare System (E.T., G.C.), Los Angeles, CA; School of Nursing (K.G.), UCLA, Los Angeles, CA; Department of Radiology and Imaging Sciences, Center for Neuroimaging (A.J.S., L.G.A.), Department of Neurology (L.G.A.), and Department of Medical and Molecular Genetics (L.G.A.), School of Medicine, Indiana University, Indianapolis; Department of Pathology and Laboratory Medicine (L.M.S., J.Q.T.), University of Pennsylvania School of Medicine, Philadelphia; Department of Public Health and Neuroscience (W.J.J.), UC Berkeley, CA; and Department of Veterans' Affairs Medical Center (M.W.W.), San Francisco, CA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1212/NXG.0000000000000022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4809461PMC
October 2015

β-amyloid disrupts human NREM slow waves and related hippocampus-dependent memory consolidation.

Nat Neurosci 2015 Jul 1;18(7):1051-7. Epub 2015 Jun 1.

1] Sleep and Neuroimaging Laboratory, University of California, Berkeley, California, USA. [2] Helen Wills Neuroscience Institute, University of California, Berkeley, California, USA.

View Article

Download full-text PDF

Source
http://www.nature.com/articles/nn.4035
Publisher Site
http://dx.doi.org/10.1038/nn.4035DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4482795PMC
July 2015

The Alzheimer's Disease Neuroimaging Initiative 2 PET Core: 2015.

Alzheimers Dement 2015 Jul;11(7):757-71

Department of Neurology, Center for Alzheimer's Care, Imaging and Research, University of Utah, Salt Lake City, UT, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jalz.2015.05.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4510459PMC
July 2015

Impact of the Alzheimer's Disease Neuroimaging Initiative, 2004 to 2014.

Alzheimers Dement 2015 Jul;11(7):865-84

Department of Pathology and Laboratory Medicine, Center for Neurodegenerative Research, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Institute on Aging, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Alzheimer's Disease Core Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Udall Parkinson's Research Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jalz.2015.04.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4659407PMC
July 2015

2014 Update of the Alzheimer's Disease Neuroimaging Initiative: A review of papers published since its inception.

Alzheimers Dement 2015 Jun;11(6):e1-120

Institute on Aging, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Alzheimer's Disease Core Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Udall Parkinson's Research Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Department of Pathology and Laboratory Medicine, Center for Neurodegenerative Research, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jalz.2014.11.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5469297PMC
June 2015