William J Steinbach

Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC, 27710, USA; Department of Pediatrics, Duke University Medical Center, Durham, NC, 27710, USA. Electronic address:

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June 2020

FKBP12 dimerization mutations effect FK506 binding and differentially alter calcineurin inhibition in the human pathogen Aspergillus fumigatus.

Authors:

Praveen R Juvvadi Benjamin G Bobay Sophie M C Gobeil D Christopher Cole Ronald A Venters Joseph Heitman Leonard D Spicer William J Steinbach

Biochem Biophys Res Commun 2020 05 16;526(1):48-54. Epub 2020 Mar 16.

Division of Pediatric Infectious Diseases, Department of Pediatrics, Duke University Medical Center, Durham, NC, 27710, USA; Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC, 27710, USA. Electronic address:

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May 2020

A multicenter study to define the epidemiology and outcomes of Clostridioides difficile infection in pediatric hematopoietic cell and solid organ transplant recipients.

Am J Transplant 2020 08 10;20(8):2133-2142. Epub 2020 Mar 10.

Department of Pediatrics, Albert Einstein College of Medicine and Children's Hospital at Montefiore, Bronx, New York, USA.

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August 2020

Revision and Update of the Consensus Definitions of Invasive Fungal Disease From the European Organization for Research and Treatment of Cancer and the Mycoses Study Group Education and Research Consortium.

Authors:

J Peter Donnelly Sharon C Chen Carol A Kauffman William J Steinbach John W Baddley Paul E Verweij Cornelius J Clancy John R Wingard Shawn R Lockhart Andreas H Groll Tania C Sorrell Matteo Bassetti Hamdi Akan Barbara D Alexander David Andes Elie Azoulay Ralf Bialek Robert W Bradsher Stephane Bretagne Thierry Calandra Angela M Caliendo Elio Castagnola Mario Cruciani Manuel Cuenca-Estrella Catherine F Decker Sujal R Desai Brian Fisher Thomas Harrison Claus Peter Heussel Henrik E Jensen Christopher C Kibbler Dimitrios P Kontoyiannis Bart-Jan Kullberg Katrien Lagrou Frédéric Lamoth Thomas Lehrnbecher Jurgen Loeffler Olivier Lortholary Johan Maertens Oscar Marchetti Kieren A Marr Henry Masur Jacques F Meis C Orla Morrisey Marcio Nucci Luis Ostrosky-Zeichner Livio Pagano Thomas F Patterson John R Perfect Zdenek Racil Emmanuel Roilides Marcus Ruhnke Cornelia Schaefer Prokop Shmuel Shoham Monica A Slavin David A Stevens George R Thompson Jose A Vazquez Claudio Viscoli Thomas J Walsh Adilia Warris L Joseph Wheat P Lewis White Theoklis E Zaoutis Peter G Pappas

Clin Infect Dis 2020 Sep;71(6):1367-1376

Department of Medicine, Division of Infectious Diseases, University of Alabama at Birmingham, Birmingham, Alabama, USA.

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September 2020

Guideline for Antibacterial Prophylaxis Administration in Pediatric Cancer and Hematopoietic Stem Cell Transplantation.

Clin Infect Dis 2020 Jun;71(1):226-236

Division of Haematology/Oncology, The Hospital for Sick Children, Toronto, Ontario, Canada.

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June 2020

Harnessing calcineurin-FK506-FKBP12 crystal structures from invasive fungal pathogens to develop antifungal agents.

Nat Commun 2019 09 19;10(1):4275. Epub 2019 Sep 19.

Division of Pediatric Infectious Diseases, Department of Pediatrics, Duke University Medical Center, Durham, NC, 27710, USA.

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September 2019

Calcineurin-dependent dephosphorylation of the transcription factor CrzA at specific sites controls conidiation, stress tolerance, and virulence of Aspergillus fumigatus.

Authors:

E Keats Shwab Praveen R Juvvadi Greg Waitt Erik J Soderblom Blake C Barrington Yohannes G Asfaw M Arthur Moseley William J Steinbach

Mol Microbiol 2019 07 15;112(1):62-80. Epub 2019 Apr 15.

Division of Pediatric Infectious Diseases, Department of Pediatrics, Duke University Medical Center, Durham, NC, USA.

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July 2019

Reduction in Mortality after Umbilical Cord Blood Transplantation in Children Over a 20-Year Period (1995-2014).

Authors:

Lisa P Spees Paul L Martin Joanne Kurtzberg Andre Stokhuyzen Lauren McGill Vinod K Prasad Timothy A Driscoll Suhag H Parikh Kristin M Page Richard Vinesett Christopher Severyn Anthony D Sung Alan D Proia Kirsten Jenkins Mehreen Arshad William J Steinbach Patrick C Seed Matthew S Kelly

Biol Blood Marrow Transplant 2019 04 24;25(4):756-763. Epub 2018 Nov 24.

Division of Pediatric Infectious Diseases, Duke University Medical Center, Durham, North Carolina. Electronic address:

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April 2019

Funding Pediatric Subspecialty Training: Are T32 Grants the Future?

Authors:

William J Steinbach Daniel K Benjamin John W Sleasman

J Pediatr 2018 11;202:4-7.e1

Division of Pediatric Allergy and Immunology, Department of Pediatrics, Duke University, Durham, NC.

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November 2018

Kin1 kinase localizes at the hyphal septum and is dephosphorylated by calcineurin but is dispensable for septation and virulence in the human pathogen Aspergillus fumigatus.

Authors:

Praveen R Juvvadi D Christopher Cole Katie Falloon Greg Waitt Erik J Soderblom M Arthur Moseley William J Steinbach

Biochem Biophys Res Commun 2018 11 4;505(3):740-746. Epub 2018 Oct 4.

Division of Pediatric Infectious Diseases, Department of Pediatrics, Duke University Medical Center, Durham, USA. Electronic address:

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November 2018

A Multicenter Consortium to Define the Epidemiology and Outcomes of Pediatric Solid Organ Transplant Recipients With Inpatient Respiratory Virus Infection.

Authors:

Lara Danziger-Isakov William J Steinbach Grant Paulsen Flor M Munoz Leigh R Sweet Michael Green Marian G Michaels Janet A Englund Alastair Murray Natasha Halasa Daniel E Dulek Rebecca Pellett Madan Betsy C Herold Brian T Fisher

J Pediatric Infect Dis Soc 2019 Jul;8(3):197-204

Division of Infectious Diseases, Department of Pediatrics, Pennsylvania.

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July 2019

Special Issue "Aspergillus fumigatus: From Diagnosis to Therapy".

Authors:

William J Steinbach

J Fungi (Basel) 2016 Dec 8;2(4). Epub 2016 Dec 8.

Division of Pediatric Infectious Diseases, Department of Pediatrics, Duke University Medical Center, Durham, NC 27710, USA.

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December 2016

Scanning Quadrupole Data-Independent Acquisition, Part B: Application to the Analysis of the Calcineurin-Interacting Proteins during Treatment of Aspergillus fumigatus with Azole and Echinocandin Antifungal Drugs.

Authors:

Praveen R Juvvadi M Arthur Moseley Christopher J Hughes Erik J Soderblom Sarah Lennon Simon R Perkins J Will Thompson Scott J Geromanos Jason Wildgoose Keith Richardson James I Langridge Johannes P C Vissers William J Steinbach

J Proteome Res 2018 02 29;17(2):780-793. Epub 2017 Dec 29.

Division of Pediatric Infectious Diseases, Department of Pediatrics, Duke University Medical Center , Durham, North Carolina 27710, United States.

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February 2018

The tail domain of the class V myosin MyoE orchestrates septal localization and hyphal growth.

Authors:

Hilary Renshaw José M Vargas-Muñiz Praveen R Juvvadi Amber D Richards Greg Waitt Erik J Soderblom M Arthur Moseley William J Steinbach

J Cell Sci 2018 02 7;131(3). Epub 2018 Feb 7.

Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC 27710, USA

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February 2018

A Multicenter Consortium to Define the Epidemiology and Outcomes of Inpatient Respiratory Viral Infections in Pediatric Hematopoietic Stem Cell Transplant Recipients.

Authors:

Brian T Fisher Lara Danziger-Isakov Leigh R Sweet Flor M Munoz Gabriela Maron Elaine Tuomanen Alistair Murray Janet A Englund Daniel Dulek Natasha Halasa Michael Green Marian G Michaels Rebecca Pellett Madan Betsy C Herold William J Steinbach

J Pediatric Infect Dis Soc 2018 Dec;7(4):275-282

Departments of Pediatrics and Molecular Genetics and Microbiology, Duke University, Durham, North Carolina.

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December 2018

Phosphorylation of Aspergillus fumigatus PkaR impacts growth and cell wall integrity through novel mechanisms.

Authors:

Elliot K Shwab Praveen R Juvvadi Greg Waitt Erik J Soderblom Martin A Moseley Nathan I Nicely William J Steinbach

FEBS Lett 2017 11 9;591(22):3730-3744. Epub 2017 Nov 9.

Division of Pediatric Infectious Diseases, Department of Pediatrics, Duke University Medical Center, Durham, NC, USA.

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November 2017

Role of Molecular Biomarkers in the Diagnosis of Invasive Fungal Diseases in Children.

Authors:

Anna R Huppler Brian T Fisher Thomas Lehrnbecher Thomas J Walsh William J Steinbach

J Pediatric Infect Dis Soc 2017 Sep;6(suppl_1):S32-S44

Division of Pediatric Infectious Diseases.

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September 2017

Recognition and Clinical Presentation of Invasive Fungal Disease in Neonates and Children.

Authors:

Jill King Zoi-Dorothea Pana Thomas Lehrnbecher William J Steinbach Adilia Warris

J Pediatric Infect Dis Soc 2017 Sep;6(suppl_1):S12-S21

Aberdeen Fungal Group, Medical Research Council Centre for Medical Mycology, Institute of Medical Sciences, University of Aberdeen, and the Royal Aberdeen Children's Hospital, United Kingdom.

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September 2017