William J Jusko

William J Jusko

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William J Jusko

Publications by authors named "William J Jusko"

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Effects of ritonavir-boosted protease inhibitors on combined oral contraceptive pharmacokinetics and pharmacodynamics in HIV-positive women.

Contraception 2019 Oct 10;100(4):283-287. Epub 2019 Jun 10.

Department of Obstetrics and Gynecology, Keck School of Medicine of University of Southern California, Los Angeles, CA 90033, USA.

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http://dx.doi.org/10.1016/j.contraception.2019.06.002DOI Listing
October 2019

Modeling Corticosteroid Pharmacokinetics and Pharmacodynamics, Part III: Estrous Cycle and Estrogen Receptor-Dependent Antagonism of Glucocorticoid-Induced Leucine Zipper (GILZ) Enhancement by Corticosteroids.

J Pharmacol Exp Ther 2019 Aug 13;370(2):337-349. Epub 2019 Jun 13.

Departments of Pharmaceutical Sciences (V.S.A., D.C.D., R.R.A., W.J.J.) and Biological Sciences (D.C.D., R.R.A.), State University of New York at Buffalo, Buffalo, New York

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http://dx.doi.org/10.1124/jpet.119.257543DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6658921PMC
August 2019

Modeling Corticosteroid Pharmacokinetics and Pharmacodynamics, Part II: Sex Differences in Methylprednisolone Pharmacokinetics and Corticosterone Suppression.

J Pharmacol Exp Ther 2019 Aug 13;370(2):327-336. Epub 2019 Jun 13.

Departments of Pharmaceutical Sciences (V.S.A., D.C.D., T.N., R.R.A., W.J.J.) and Biological Sciences (D.C.D., R.R.A.), State University of New York at Buffalo, Buffalo, New York; and DMPK Research Department, Teijin Institute for Biomedical Research, Teijin Pharma, Tokyo, Japan (T.N.)

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http://dx.doi.org/10.1124/jpet.119.257527DOI Listing
August 2019

Modeling Corticosteroid Pharmacokinetics and Pharmacodynamics, Part I: Determination and Prediction of Dexamethasone and Methylprednisolone Tissue Binding in the Rat.

J Pharmacol Exp Ther 2019 Aug 13;370(2):318-326. Epub 2019 Jun 13.

Departments of Pharmaceutical Sciences (V.S.A., D.S., D.C.D., R.R.A., W.J.J.) and Biological Sciences (D.C.D., R.R.A.), State University of New York at Buffalo, Buffalo, New York

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http://dx.doi.org/10.1124/jpet.119.257519DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6658919PMC
August 2019

Population Pharmacokinetics of Vamorolone (VBP15) in Healthy Men and Boys With Duchenne Muscular Dystrophy.

J Clin Pharmacol 2019 Jul 11;59(7):979-988. Epub 2019 Feb 11.

Department of Pharmaceutical Sciences, University at Buffalo, State University of New York, Buffalo, NY, USA.

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http://dx.doi.org/10.1002/jcph.1388DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6548694PMC
July 2019

Modeling Combined Anti-Inflammatory Effects of Dexamethasone and Tofacitinib in Arthritic Rats.

AAPS J 2019 Jul 24;21(5):93. Epub 2019 Jul 24.

Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences, State University of New York at Buffalo, 404 Pharmacy Building, Buffalo, NY, 14214-8033, USA.

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http://dx.doi.org/10.1208/s12248-019-0362-6DOI Listing
July 2019

ATLAS mPBPK: a MATLAb-based tool for modeling and Simulation of minimal Physiologically Based PharmacoKinetic models.

CPT Pharmacometrics Syst Pharmacol 2019 Jun 2. Epub 2019 Jun 2.

University at Buffalo, School of Pharmacy and Pharmaceutical Sciences, Buffalo, NY, USA.

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http://dx.doi.org/10.1002/psp4.12441DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6709424PMC
June 2019

Pharmacokinetics of the 1.5 mg levonorgestrel emergency contraceptive in women with normal, obese and extremely obese body mass index.

Contraception 2019 May 28;99(5):306-311. Epub 2019 Jan 28.

Department of Pharmaceutical Sciences, State University of New York at Buffalo, Buffalo, New York.

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http://dx.doi.org/10.1016/j.contraception.2019.01.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6499670PMC
May 2019

Altered pharmacokinetics of combined oral contraceptives in obesity - multistudy assessment.

Contraception 2019 Apr 23;99(4):256-263. Epub 2019 Jan 23.

Department of Pharmaceutical Sciences, University at Buffalo, State University of New York, Buffalo, NY 14214, USA. Electronic address:

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http://dx.doi.org/10.1016/j.contraception.2018.12.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441376PMC
April 2019

Pathway-Based Analysis of the Liver Response to Intravenous Methylprednisolone Administration in Rats: Acute Versus Chronic Dosing.

Gene Regul Syst Bio 2019 15;13:1177625019840282. Epub 2019 Apr 15.

Department of Biomedical Engineering, Robert Wood Johnson Medical School, Rutgers, The State University of New Jersey, Piscataway, NJ, USA.

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http://dx.doi.org/10.1177/1177625019840282DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6466473PMC
April 2019

Pharmacokinetics and pharmacodynamics of liposomal chemophototherapy with short drug-light intervals.

J Control Release 2019 Mar 23;297:39-47. Epub 2019 Jan 23.

Department of Biomedical Engineering, University at Buffalo, State University of New York, Buffalo, NY 14260, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jconrel.2019.01.030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6399029PMC
March 2019

Indirect pharmacodynamic models for responses with circadian removal.

J Pharmacokinet Pharmacodyn 2019 Feb 29;46(1):89-101. Epub 2019 Jan 29.

Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences, State University of New York at Buffalo, Buffalo, NY, 14214, USA.

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http://dx.doi.org/10.1007/s10928-019-09620-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6447046PMC
February 2019

Daily variation of gene expression in diverse rat tissues.

PLoS One 2018 10;13(5):e0197258. Epub 2018 May 10.

Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences, State University of New York at Buffalo, Buffalo, New York, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0197258PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5945012PMC
November 2018

Modeling circadian variability of core-clock and clock-controlled genes in four tissues of the rat.

PLoS One 2018 12;13(6):e0197534. Epub 2018 Jun 12.

Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences, State University of New York at Buffalo, Buffalo, NY, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0197534PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5997360PMC
November 2018

Role of Interstitial Fluid Turnover on Target Suppression by Therapeutic Biologics Using a Minimal Physiologically Based Pharmacokinetic Model.

J Pharmacol Exp Ther 2018 10 12;367(1):1-8. Epub 2018 Jul 12.

Department of Pharmacy, Shengjing Hospital of China Medical University, Shenyang, China (X.L.); Division of Pharmacotherapy and Experimental Therapeutics, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina (X.L., Y.C.); and Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical, Sciences, State University of New York at Buffalo, Buffalo, New York (W.J.J.)

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http://dx.doi.org/10.1124/jpet.118.250134DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6123664PMC
October 2018

Physiologically-based pharmacokinetic and pharmacodynamic models for gemcitabine and birinapant in pancreatic cancer xenografts.

J Pharmacokinet Pharmacodyn 2018 10 1;45(5):733-746. Epub 2018 Aug 1.

Department of Pharmaceutical Sciences, University at Buffalo, The State University of New York, Buffalo, USA.

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http://dx.doi.org/10.1007/s10928-018-9603-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6160358PMC
October 2018

Modeling Corticosteroid Pharmacogenomics and Proteomics in Rat Liver.

J Pharmacol Exp Ther 2018 10 7;367(1):168-183. Epub 2018 Aug 7.

Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences (V.S.A., S.S., D.C.D., R.R.A., W.J.J.) and Department of Biological Sciences (D.C.D., R.R.A.), State University of New York at Buffalo, Buffalo, New York

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http://dx.doi.org/10.1124/jpet.118.251959DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6146373PMC
October 2018

Multi-Scale Network Model Supported by Proteomics for Analysis of Combined Gemcitabine and Birinapant Effects in Pancreatic Cancer Cells.

CPT Pharmacometrics Syst Pharmacol 2018 09 9;7(9):549-561. Epub 2018 Aug 9.

Department of Pharmaceutical Sciences, University at Buffalo, The State University of New York, Buffalo, New York, USA.

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http://dx.doi.org/10.1002/psp4.12320DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6157671PMC
September 2018

Modeling Sex Differences in Anti-inflammatory Effects of Dexamethasone in Arthritic Rats.

Pharm Res 2018 Sep 6;35(11):203. Epub 2018 Sep 6.

Department of Pharmaceutical Sciences School of Pharmacy and Pharmaceutical Sciences, State University of New York at Buffalo, Buffalo, New York, 14214, USA.

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http://dx.doi.org/10.1007/s11095-018-2483-5DOI Listing
September 2018

Receptor/gene/protein-mediated signaling connects methylprednisolone exposure to metabolic and immune-related pharmacodynamic actions in liver.

J Pharmacokinet Pharmacodyn 2018 08 27;45(4):557-575. Epub 2018 Apr 27.

Department of Pharmaceutical Sciences, State University of New York at Buffalo, Buffalo, NY, 14214, USA.

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http://dx.doi.org/10.1007/s10928-018-9585-xDOI Listing
August 2018

Assessment of Three-Drug Combination Pharmacodynamic Interactions in Pancreatic Cancer Cells.

AAPS J 2018 06 27;20(5):80. Epub 2018 Jun 27.

Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences, University at Buffalo, State University of New York, Buffalo, New York, 14214, USA.

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http://dx.doi.org/10.1208/s12248-018-0235-4DOI Listing
June 2018

Development and Translational Application of a Minimal Physiologically Based Pharmacokinetic Model for a Monoclonal Antibody against Interleukin 23 (IL-23) in IL-23-Induced Psoriasis-Like Mice.

J Pharmacol Exp Ther 2018 04 2;365(1):140-155. Epub 2018 Feb 2.

Biologics Development Sciences, Janssen BioTherapeutics (X.C., X.J., R.D., B.G., T.M., W.W.) and Global Clinical Pharmacology (H.Z.), Janssen R&D, Spring House, Pennsylvania; and Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences, State University of New York at Buffalo, Buffalo, New York (W.J.J.)

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http://dx.doi.org/10.1124/jpet.117.244855DOI Listing
April 2018

Pharmacogenomic Variability of Oral Baclofen Clearance and Clinical Response in Children With Cerebral Palsy.

PM R 2018 03 1;10(3):235-243. Epub 2017 Sep 1.

Division of Rehabilitation Medicine, Children's Mercy-Kansas City, 2401 Gillham Road, Kansas City, MO 64108; Division of Clinical Pharmacology, Toxicology and Therapeutic Innovation, Children's Mercy, Kansas City, MO.

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http://dx.doi.org/10.1016/j.pmrj.2017.08.441DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5880219PMC
March 2018

Proteomic Analysis of Combined Gemcitabine and Birinapant in Pancreatic Cancer Cells.

Front Pharmacol 2018 19;9:84. Epub 2018 Feb 19.

Department of Pharmaceutical Sciences, University at Buffalo, The State University of New York, Buffalo, NY, United States.

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http://dx.doi.org/10.3389/fphar.2018.00084DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5827530PMC
February 2018

Mechanistic Multi-Tissue Modeling of Glucocorticoid-Induced Leucine Zipper Regulation: Integrating Circadian Gene Expression with Receptor-Mediated Corticosteroid Pharmacodynamics.

J Pharmacol Exp Ther 2017 10 20;363(1):45-57. Epub 2017 Jul 20.

Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences (V.S.A., D.C.D., R.R.A., W.J.J.), and Department of Biological Sciences (D.C.D., R.R.A.), State University of New York at Buffalo, Buffalo, New York

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http://dx.doi.org/10.1124/jpet.117.242990DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5596815PMC
October 2017

Characterization and Interspecies Scaling of rhTNF- Pharmacokinetics with Minimal Physiologically Based Pharmacokinetic Models.

Drug Metab Dispos 2017 07 14;45(7):798-806. Epub 2017 Apr 14.

Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences (X.C., D.C.D, R.R.A, W.J.J.), and Department of Biological Sciences (D.C.D, R.R.A), State University of New York at Buffalo, Buffalo, New York

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http://dx.doi.org/10.1124/dmd.116.074799DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5469399PMC
July 2017

Interrelationships between Infliximab and Recombinant Tumor Necrosis Factor- in Plasma Using Minimal Physiologically Based Pharmacokinetic Models.

Drug Metab Dispos 2017 07 14;45(7):790-797. Epub 2017 Apr 14.

Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences (X.C., D.C.D., R.R.A., W.J.J.), and Department of Biological Sciences (D.C.D., R.R.A.), State University of New York at Buffalo, Buffalo, New York

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http://dx.doi.org/10.1124/dmd.116.074807DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5478907PMC
July 2017

Modeling Combined Immunosuppressive and Anti-inflammatory Effects of Dexamethasone and Naproxen in Rats Predicts the Steroid-Sparing Potential of Naproxen.

Drug Metab Dispos 2017 07 17;45(7):834-845. Epub 2017 Apr 17.

Clinical Pharmacokinetics Laboratory, School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing, Jiangsu, People's Republic of China (X.L., X.C.); Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences (X.L., D.C.D., D.S., R.R.A., W.J.J.), and Department of Biological Sciences (D.C.D., R.R.A.), State University of New York at Buffalo, Buffalo, New York

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http://dx.doi.org/10.1124/dmd.117.075614DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5469402PMC
July 2017

Effect of Disease-Related Changes in Plasma Albumin on the Pharmacokinetics of Naproxen in Male and Female Arthritic Rats.

Drug Metab Dispos 2017 05 28;45(5):476-483. Epub 2017 Feb 28.

Clinical Pharmacokinetics Laboratory, School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing, Jiangsu, China (X.L.); Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences (X.L., D.C.D., R.R.A., W.J.J.), and Department of Biological Sciences (D.C.D., R.R.A.), State University of New York at Buffalo, Buffalo, New York

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http://dx.doi.org/10.1124/dmd.116.074500DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5399645PMC
May 2017

Modeling Sex Differences in Pharmacokinetics, Pharmacodynamics, and Disease Progression Effects of Naproxen in Rats with Collagen-Induced Arthritis.

Drug Metab Dispos 2017 05 28;45(5):484-491. Epub 2017 Feb 28.

Clinical Pharmacokinetics Laboratory, School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing, Jiangsu, China (X.L.); Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences, State University of New York at Buffalo, Buffalo, New York (X.L., D.C.D., R.R.A., W.J.J.); and Department of Biological Sciences, State University of New York at Buffalo, Buffalo, New York (D.C.D., R.R.A.)

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http://dx.doi.org/10.1124/dmd.116.074526DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5399646PMC
May 2017

Functional proteomic analysis of corticosteroid pharmacodynamics in rat liver: Relationship to hepatic stress, signaling, energy regulation, and drug metabolism.

J Proteomics 2017 05 14;160:84-105. Epub 2017 Mar 14.

Department of Pharmaceutical Sciences, State University of New York at Buffalo, NY, United States. Electronic address:

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http://dx.doi.org/10.1016/j.jprot.2017.03.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5455150PMC
May 2017

Effects of High-Fat Feeding on Skeletal Muscle Gene Expression in Diabetic Goto-Kakizaki Rats.

Gene Regul Syst Bio 2017 29;11:1177625017710009. Epub 2017 May 29.

Department of Biological Sciences, State University of New York at Buffalo, Buffalo, NY, USA.

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http://dx.doi.org/10.1177/1177625017710009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5457139PMC
May 2017

Target-mediated drug disposition with drug-drug interaction, Part I: single drug case in alternative formulations.

J Pharmacokinet Pharmacodyn 2017 02 10;44(1):17-26. Epub 2017 Jan 10.

Department of Mathematics and Statistics, University of Konstanz, P.O. Box 195, 78457, Konstanz, Germany.

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http://dx.doi.org/10.1007/s10928-016-9501-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5478890PMC
February 2017

Target mediated drug disposition with drug-drug interaction, Part II: competitive and uncompetitive cases.

J Pharmacokinet Pharmacodyn 2017 02 10;44(1):27-42. Epub 2017 Jan 10.

Department of Mathematics and Statistics, University of Konstanz, PO Box 195, 78457, Konstanz, Germany.

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http://dx.doi.org/10.1007/s10928-016-9502-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5470635PMC
February 2017

Understanding Physiology in the Continuum: Integration of Information from Multiple - Levels.

Front Pharmacol 2017 27;8:91. Epub 2017 Feb 27.

Department of Biomedical Engineering, Rutgers University, PiscatawayNJ, USA; Department of Chemical Engineering, Rutgers University, PiscatawayNJ, USA.

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http://dx.doi.org/10.3389/fphar.2017.00091DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5327699PMC
February 2017

Perspectives on variability in pharmacokinetics of an oral contraceptive product.

Authors:
William J Jusko

Contraception 2017 01 27;95(1):5-9. Epub 2016 Jul 27.

Department of Pharmaceutical Sciences, University at Buffalo, 404 Kapoor Hall, Buffalo, NY 14214, USA. Electronic address:

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http://dx.doi.org/10.1016/j.contraception.2016.07.019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5422991PMC
January 2017

Clarification of contraceptive drug pharmacokinetics in obesity.

Authors:
William J Jusko

Contraception 2017 01 16;95(1):10-16. Epub 2016 Aug 16.

Department of Pharmaceutical Sciences, University at Buffalo, Buffalo, NY 14214, USA. Electronic address:

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http://dx.doi.org/10.1016/j.contraception.2016.08.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5422994PMC
January 2017

Pharmacodynamic Modeling of Cell Cycle Effects for Gemcitabine and Trabectedin Combinations in Pancreatic Cancer Cells.

Front Pharmacol 2016 15;7:421. Epub 2016 Nov 15.

Department of Pharmaceutical Sciences, University at Buffalo, State University of New York Buffalo, NY, USA.

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http://dx.doi.org/10.3389/fphar.2016.00421DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5108803PMC
November 2016

Assessment of non-linear combination effect terms for drug-drug interactions.

J Pharmacokinet Pharmacodyn 2016 10 16;43(5):461-79. Epub 2016 Sep 16.

Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences, State University of New York at Buffalo, Buffalo, NY, 14214, USA.

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http://dx.doi.org/10.1007/s10928-016-9490-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5439368PMC
October 2016

Pharmacodynamic modeling of combined chemotherapeutic effects predicts synergistic activity of gemcitabine and trabectedin in pancreatic cancer cells.

Cancer Chemother Pharmacol 2016 Jan 25;77(1):181-93. Epub 2015 Nov 25.

Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences, State University of New York at Buffalo, Buffalo, NY, 14214, USA.

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http://dx.doi.org/10.1007/s00280-015-2907-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4707118PMC
January 2016

Across-Species Scaling of Monoclonal Antibody Pharmacokinetics Using a Minimal PBPK Model.

Pharm Res 2015 Oct 5;32(10):3269-81. Epub 2015 May 5.

Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences, State University of New York at Buffalo, Buffalo, New York, 14214, USA.

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http://dx.doi.org/10.1007/s11095-015-1703-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4580522PMC
October 2015

Mechanism-based population pharmacokinetic and pharmacodynamic modeling of intravenous and intranasal dexmedetomidine in healthy subjects.

Eur J Clin Pharmacol 2015 Oct 2;71(10):1197-207. Epub 2015 Aug 2.

Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences, 404 Kapoor Hall, State University of New York at Buffalo, Buffalo, NY, 14214, USA.

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http://dx.doi.org/10.1007/s00228-015-1913-0DOI Listing
October 2015

Mechanism-based mathematical modeling of combined gemcitabine and birinapant in pancreatic cancer cells.

J Pharmacokinet Pharmacodyn 2015 Oct 8;42(5):477-96. Epub 2015 Aug 8.

Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences, State University of New York at Buffalo, Buffalo, NY, 14214, USA.

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http://link.springer.com/10.1007/s10928-015-9429-x
Publisher Site
http://dx.doi.org/10.1007/s10928-015-9429-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4583820PMC
October 2015

Preface to the special issue to honor Gerhard Levy and 50 years of PK/PD.

J Pharmacokinet Pharmacodyn 2015 Oct;42(5):427

Department of Pharmaceutical Sciences, State University of New York at Buffalo, Buffalo, NY, 14214, USA.

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http://dx.doi.org/10.1007/s10928-015-9443-zDOI Listing
October 2015

Perspectives on the history and scientific contributions of Gerhard Levy.

J Pharmacokinet Pharmacodyn 2015 Oct 24;42(5):429-46. Epub 2015 Sep 24.

Department of Pharmaceutical Sciences, State University of New York at Buffalo, Buffalo, NY, 14214, USA.

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http://dx.doi.org/10.1007/s10928-015-9442-0DOI Listing
October 2015

Modeling effects of dexamethasone on disease progression of bone mineral density in collagen-induced arthritic rats.

Pharmacol Res Perspect 2015 Oct 3;3(5):e00169. Epub 2015 Aug 3.

Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences, University at Buffalo Buffalo, New York, 14214.

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http://dx.doi.org/10.1002/prp2.169DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4618640PMC
October 2015

Effects of High Fat Feeding on Adipose Tissue Gene Expression in Diabetic Goto-Kakizaki Rats.

Gene Regul Syst Bio 2015 10;9:15-26. Epub 2015 Aug 10.

Department of Biological Sciences, State University of New York at Buffalo, Buffalo, NY, USA. ; Department of Pharmaceutical Sciences, State University of New York at Buffalo, Buffalo, NY, USA. ; New York State Center of Excellence in Bioinformatics and Life Sciences, Buffalo, NY, USA.

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http://dx.doi.org/10.4137/GRSB.S25172DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4533846PMC
August 2015

Biodistribution of etanercept to tissues and sites of inflammation in arthritic rats.

Drug Metab Dispos 2015 Jun 1;43(6):898-907. Epub 2015 Apr 1.

Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences, (X.C., D.C.D., R.R.A., W.J.J.), Department of Biological Sciences (D.C.D., R.R.A.), and New York State Center of Excellence in Bioinformatics and Life Sciences (R.R.A., W.J.J.), State University of New York at Buffalo, Buffalo, New York

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http://dx.doi.org/10.1124/dmd.114.062901DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4429683PMC
June 2015

Quantitative tissue-specific dynamics of in vivo GILZ mRNA expression and regulation by endogenous and exogenous glucocorticoids.

Physiol Rep 2015 Jun;3(6)

Department of Pharmaceutical Sciences, State University of New York at Buffalo, Buffalo, New York Department of Biological Sciences, State University of New York at Buffalo, Buffalo, New York

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http://dx.doi.org/10.14814/phy2.12382DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4510616PMC
June 2015

Survey of monoclonal antibody disposition in man utilizing a minimal physiologically-based pharmacokinetic model.

J Pharmacokinet Pharmacodyn 2014 Dec 22;41(6):571-80. Epub 2014 Aug 22.

Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences, State University of New York at Buffalo, Buffalo, NY, 14214, USA.

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http://dx.doi.org/10.1007/s10928-014-9374-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4226811PMC
December 2014

Variability in Zucker diabetic fatty rats: differences in disease progression in hyperglycemic and normoglycemic animals.

Diabetes Metab Syndr Obes 2014 11;7:531-41. Epub 2014 Nov 11.

Department of Biological Sciences, State University of New York at Buffalo, Buffalo, NY, USA ; Department of Pharmaceutical Sciences, State University of New York at Buffalo, Buffalo, NY, USA ; New York State Center of Excellence in Bioinformatics and Life Sciences, Buffalo, NY, USA.

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http://dx.doi.org/10.2147/DMSO.S69891DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4234283PMC
November 2014

Meta-modeling of methylprednisolone effects on glucose regulation in rats.

PLoS One 2013 2;8(12):e81679. Epub 2013 Dec 2.

Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences, State University of New York at Buffalo, Buffalo, New York, United States of America.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3847111PMC
September 2014

Incorporating target-mediated drug disposition in a minimal physiologically-based pharmacokinetic model for monoclonal antibodies.

J Pharmacokinet Pharmacodyn 2014 Aug 31;41(4):375-87. Epub 2014 Jul 31.

Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences, State University of New York at Buffalo, Buffalo, NY, 14214, USA.

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http://dx.doi.org/10.1007/s10928-014-9372-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4167346PMC
August 2014

Diabetes disease progression in Goto-Kakizaki rats: effects of salsalate treatment.

Diabetes Metab Syndr Obes 2014 1;7:381-9. Epub 2014 Aug 1.

Department of Biological Sciences, University at Buffalo, Buffalo, NY, USA ; Department of Pharmaceutical Sciences, University at Buffalo, Buffalo, NY, USA ; New York State Center of Excellence in Bioinformatics and Life Sciences, Buffalo, NY, USA.

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http://dx.doi.org/10.2147/DMSO.S65818DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4128793PMC
August 2014

Tissue-specific gene expression and regulation in liver and muscle following chronic corticosteroid administration.

Gene Regul Syst Bio 2014 10;8:75-87. Epub 2014 Mar 10.

Biomedical Engineering Department, Rutgers University, Piscataway, NJ, USA. ; Chemical and Biochemical Engineering Department, Rutgers University, Piscataway, NJ, USA.

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http://dx.doi.org/10.4137/GRSB.S13134DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3956809PMC
March 2014

Second-generation minimal physiologically-based pharmacokinetic model for monoclonal antibodies.

J Pharmacokinet Pharmacodyn 2013 Oct 31;40(5):597-607. Epub 2013 Aug 31.

Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences, State University of New York at Buffalo, 404 Kapoor Hall, Buffalo, NY, 14214-8033, USA.

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http://dx.doi.org/10.1007/s10928-013-9332-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3836053PMC
October 2013

Moving from basic toward systems pharmacodynamic models.

Authors:
William J Jusko

J Pharm Sci 2013 Sep 16;102(9):2930-40. Epub 2013 May 16.

Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences, State University of New York at Buffalo, Buffalo, New York 14214, USA.

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http://dx.doi.org/10.1002/jps.23590DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3743951PMC
September 2013

Pharmacodynamic modeling of cell cycle and apoptotic effects of gemcitabine on pancreatic adenocarcinoma cells.

Cancer Chemother Pharmacol 2013 Sep 9;72(3):553-63. Epub 2013 Jul 9.

Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences, University at Buffalo, Buffalo, NY 14214, USA.

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http://dx.doi.org/10.1007/s00280-013-2226-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3777243PMC
September 2013

Physiologically based pharmacokinetic models for everolimus and sorafenib in mice.

Cancer Chemother Pharmacol 2013 May 3;71(5):1219-29. Epub 2013 Mar 3.

Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences, State University of New York at Buffalo, Buffalo, NY 14260, USA.

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http://link.springer.com/10.1007/s00280-013-2116-y
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http://dx.doi.org/10.1007/s00280-013-2116-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3755750PMC
May 2013

Synergistic interactions between sorafenib and everolimus in pancreatic cancer xenografts in mice.

Cancer Chemother Pharmacol 2013 May 3;71(5):1231-40. Epub 2013 Mar 3.

Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences, State University of New York at Buffalo, Buffalo, NY 14214, USA.

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http://dx.doi.org/10.1007/s00280-013-2117-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3752659PMC
May 2013

Pharmacokinetics, pharmacodynamics and toxicities of methotrexate in healthy and collagen-induced arthritic rats.

Biopharm Drug Dispos 2013 May 7;34(4):203-14. Epub 2013 Apr 7.

Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences, University at Buffalo, Buffalo, NY 14214, USA.

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http://dx.doi.org/10.1002/bdd.1838DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3656137PMC
May 2013

Interactions of everolimus and sorafenib in whole blood lymphocyte proliferation.

Pharm Res 2013 Mar 14;30(3):707-13. Epub 2012 Nov 14.

Department of Pharmaceutical Sciences School of Pharmacy and Pharmaceutical Sciences, State University of New York at Buffalo, Buffalo, New York, 14214, USA.

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http://dx.doi.org/10.1007/s11095-012-0909-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3726064PMC
March 2013

Glucocorticoid effects on adiponectin expression.

Vitam Horm 2012 ;90:163-86

Department of Pharmaceutical Sciences, State University of New York at Buffalo, Buffalo, New York, USA.

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http://dx.doi.org/10.1016/B978-0-12-398313-8.00007-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3693220PMC
February 2013

Evidence for a glucocorticoid receptor beta splice variant in the rat and its physiological regulation in liver.

Steroids 2013 Feb 19;78(2):312-20. Epub 2012 Dec 19.

Department of Biological Sciences, State University of New York at Buffalo, Buffalo, NY 14260, USA.

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http://dx.doi.org/10.1016/j.steroids.2012.11.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3552070PMC
February 2013

Study reanalysis using a mechanism-based pharmacokinetic/pharmacodynamic model of pramlintide in subjects with type 1 diabetes.

AAPS J 2013 Jan 2;15(1):15-29. Epub 2012 Oct 2.

Department of Pharmaceutical Sciences, University at Buffalo, State University of New York, 404 Kapoor Hall, Buffalo, NY 14214, USA.

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http://www.springerlink.com/index/10.1208/s12248-012-9409-7
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http://dx.doi.org/10.1208/s12248-012-9409-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3535104PMC
January 2013

Interactions of everolimus and sorafenib in pancreatic cancer cells.

AAPS J 2013 Jan 9;15(1):78-84. Epub 2012 Oct 9.

Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences, State University of New York at Buffalo, 404 Kapoor Hall, Buffalo, NY 14214, USA.

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http://dx.doi.org/10.1208/s12248-012-9417-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3535103PMC
January 2013

Pharmacokinetic/pharmacodynamic modeling in inflammation.

Crit Rev Biomed Eng 2012 ;40(4):295-312

Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences, University at Buffalo, Buffalo, NY 14214, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3538354PMC
January 2013

Applications of minimal physiologically-based pharmacokinetic models.

J Pharmacokinet Pharmacodyn 2012 Dec 23;39(6):711-23. Epub 2012 Nov 23.

Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences, State University of New York at Buffalo, 404 Kapoor Hall, Buffalo, NY 14214-8033, USA.

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http://dx.doi.org/10.1007/s10928-012-9280-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3539784PMC
December 2012

Effects of high fat feeding on liver gene expression in diabetic goto-kakizaki rats.

Gene Regul Syst Bio 2012 28;6:151-68. Epub 2012 Nov 28.

Department of Biological Sciences, State University of New York at Buffalo, Buffalo, NY, USA. ; Department of Pharmaceutical Sciences, State University of New York at Buffalo, Buffalo, NY, USA. ; New York State Center of Excellence in Bioinformatics and Life Sciences.

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http://dx.doi.org/10.4137/GRSB.S10371DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3516129PMC
December 2012

Use of pharmacokinetic data below lower limit of quantitation values.

Authors:
William J Jusko

Pharm Res 2012 Sep 23;29(9):2628-31. Epub 2012 Jun 23.

Department of Pharmaceutical Sciences School of Pharmacy & Pharmaceutical Sciences, University at Buffalo, Buffalo, New York 14214, USA.

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http://dx.doi.org/10.1007/s11095-012-0805-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3422429PMC
September 2012

Pharmacokinetics of salsalate and salicylic acid in normal and diabetic rats.

Biopharm Drug Dispos 2012 Sep 26;33(6):285-91. Epub 2012 Jul 26.

Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences, State University of New York at Buffalo, Buffalo, NY 14260, USA.

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http://dx.doi.org/10.1002/bdd.1797DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3440557PMC
September 2012

Pharmacokinetic/pharmacodynamic modeling of methylprednisolone effects on iNOS mRNA expression and nitric oxide during LPS-induced inflammation in rats.

Pharm Res 2012 Aug 16;29(8):2060-9. Epub 2012 Mar 16.

Department of Pharmaceutical Sciences School of Pharmacy & Pharmaceutical Sciences, State University of New York at Buffalo, 565 Hochstetter Hall, Buffalo, New York 14260, USA.

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http://dx.doi.org/10.1007/s11095-012-0733-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3400266PMC
August 2012

Modeling disease progression and rosiglitazone intervention in type 2 diabetic Goto-Kakizaki rats.

J Pharmacol Exp Ther 2012 Jun 29;341(3):617-25. Epub 2012 Feb 29.

Department of Pharmaceutical Sciences, University at Buffalo, State University of New York, Buffalo, NY 14260, USA.

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http://dx.doi.org/10.1124/jpet.112.192419DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3362884PMC
June 2012

Target-mediated pharmacokinetic and pharmacodynamic model of exendin-4 in rats, monkeys, and humans.

Drug Metab Dispos 2012 May 15;40(5):990-7. Epub 2012 Feb 15.

565 Hochstetter Hall, Department of Pharmaceutical Sciences, University at Buffalo, State University of New York, Buffalo, NY 14260, USA.

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http://dx.doi.org/10.1124/dmd.111.042291DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3336795PMC
May 2012

Pharmacokinetic/pharmacodynamic modeling of GLP-1 in healthy rats.

Pharm Res 2012 Apr 17;29(4):1078-86. Epub 2011 Dec 17.

Department of Pharmaceutical Sciences School of Pharmacy & Pharmaceutical Sciences, State University of New York at Buffalo, 565 Hochstetter Hall, Buffalo, New York 14260, USA.

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http://dx.doi.org/10.1007/s11095-011-0652-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3412591PMC
April 2012

Mechanism-based population modelling of the effects of vildagliptin on GLP-1, glucose and insulin in patients with type 2 diabetes.

Br J Clin Pharmacol 2012 Mar;73(3):373-90

Department of Pharmaceutical Sciences, State University of New York at Buffalo, Buffalo, NY 14260, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3370342PMC
http://dx.doi.org/10.1111/j.1365-2125.2011.04109.xDOI Listing
March 2012

Mechanism-based population pharmacokinetic modelling in diabetes: vildagliptin as a tight binding inhibitor and substrate of dipeptidyl peptidase IV.

Br J Clin Pharmacol 2012 Mar;73(3):391-401

Department of Pharmaceutical Sciences, State University of New York at Buffalo, Buffalo, NY 14260, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3370343PMC
http://dx.doi.org/10.1111/j.1365-2125.2011.04108.xDOI Listing
March 2012

Modeling diabetes disease progression and salsalate intervention in Goto-Kakizaki rats.

J Pharmacol Exp Ther 2011 Dec 8;339(3):896-904. Epub 2011 Sep 8.

Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences, State University of New York, Buffalo, NY 14260, USA.

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http://jpet.aspetjournals.org/content/early/2011/09/08/jpet.
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http://dx.doi.org/10.1124/jpet.111.185686DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3226370PMC
December 2011

Population pharmacokinetic-pharmacodynamic-disease progression model for effects of anakinra in Lewis rats with collagen-induced arthritis.

J Pharmacokinet Pharmacodyn 2011 Dec 16;38(6):769-86. Epub 2011 Oct 16.

Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences, University at Buffalo, Buffalo, NY 14260, USA.

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http://dx.doi.org/10.1007/s10928-011-9219-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3407879PMC
December 2011

Pharmacokinetic-pharmacodynamic disease progression model for effect of etanercept in Lewis rats with collagen-induced arthritis.

Pharm Res 2011 Jul 1;28(7):1622-30. Epub 2011 Mar 1.

Department of Pharmaceutical Sciences School of Pharmacy & Pharmaceutical Sciences, University at Buffalo, Buffalo, New York 14260, USA.

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http://dx.doi.org/10.1007/s11095-011-0396-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3726066PMC
July 2011

Dynamic modeling of methylprednisolone effects on body weight and glucose regulation in rats.

J Pharmacokinet Pharmacodyn 2011 Jun 11;38(3):293-316. Epub 2011 Mar 11.

Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences, State University of New York at Buffalo, Buffalo, NY 14260, USA.

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http://dx.doi.org/10.1007/s10928-011-9194-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3407886PMC
June 2011

Mechanistic modeling of the effects of glucocorticoids and circadian rhythms on adipokine expression.

J Pharmacol Exp Ther 2011 Jun 11;337(3):734-46. Epub 2011 Mar 11.

Department of Biological Sciences, State University of New York, Buffalo, NY 14260, USA.

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http://dx.doi.org/10.1124/jpet.111.179960DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3101012PMC
June 2011

Assessment of pharmacologic area under the curve when baselines are variable.

Pharm Res 2011 May 14;28(5):1081-9. Epub 2011 Jan 14.

Biomedical Engineering Department, Rutgers University, 599 Taylor Road, Piscataway, New Jersey 08854, USA.

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http://dx.doi.org/10.1007/s11095-010-0363-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3152796PMC
May 2011

Differential muscle gene expression as a function of disease progression in Goto-Kakizaki diabetic rats.

Mol Cell Endocrinol 2011 May 26;338(1-2):10-7. Epub 2011 Feb 26.

Department of Biological Sciences, State University of New York at Buffalo, Buffalo, NY 14260, USA.

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http://dx.doi.org/10.1016/j.mce.2011.02.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3093670PMC
May 2011

Pharmacokinetic and pharmacodynamic modeling of exendin-4 in type 2 diabetic Goto-Kakizaki rats.

J Pharmacol Exp Ther 2011 Mar 14;336(3):881-90. Epub 2010 Dec 14.

Department of Pharmaceutical Sciences, State University of New York, Buffalo, NY, USA.

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http://dx.doi.org/10.1124/jpet.110.175752DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3061535PMC
March 2011

Mechanism-based disease progression modeling of type 2 diabetes in Goto-Kakizaki rats.

J Pharmacokinet Pharmacodyn 2011 Feb 3;38(1):143-62. Epub 2010 Dec 3.

Department of Pharmaceutical Sciences, State University of New York, 565 Hochstetter Hall, Buffalo, NY, USA.

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http://dx.doi.org/10.1007/s10928-010-9182-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3727409PMC
February 2011

Adipose tissue deficiency and chronic inflammation in diabetic Goto-Kakizaki rats.

PLoS One 2011 Feb 25;6(2):e17386. Epub 2011 Feb 25.

Department of Biological Sciences, State University of New York at Buffalo, Buffalo, New York, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0017386PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3045458PMC
February 2011

Mechanistic population modeling of diabetes disease progression in Goto-Kakizaki rat muscle.

Biopharm Drug Dispos 2011 Jan 5;32(1):50-63. Epub 2010 Dec 5.

Department of Biological Sciences, State University of New York at Buffalo, Buffalo, NY 14260, USA.

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http://dx.doi.org/10.1002/bdd.738DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3080028PMC
January 2011

Circadian signatures in rat liver: from gene expression to pathways.

BMC Bioinformatics 2010 Nov 1;11:540. Epub 2010 Nov 1.

Chemical and Biochemical Engineering Department, Rutgers University Piscataway, NJ 08854, USA.

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http://dx.doi.org/10.1186/1471-2105-11-540DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2990769PMC
November 2010