Publications by authors named "William Greenhalf"

79Publications

Cathepsin D Expression and Gemcitabine Resistance in Pancreatic Cancer.

JNCI Cancer Spectr 2020 Feb 16;4(1):pkz060. Epub 2019 Aug 16.

Department of Medicine II (UMM, EG, QL, FL, GB, JM), Department of Medicine III (SK, MvBB, VH, SB), Department of Radiation Oncology (CB), University Hospital, LMU-Munich, Munich, Germany; Department of Medicine A, University Medicine Greifswald, Greifswald, Germany (UMM, EL, GB, FUW, MS, MML, JM); National Institute for Health Research Liverpool Pancreas Biomedical Research Centre, University of Liverpool, UK (EC, WG, CH, PG, JPN); Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany (SO, TKi); Leibniz Institute for Prevention Research and Epidemiology - BIPS, Bremen, Germany (MM); Department of General, Visceral, and Tumor Surgery, University Hospital Cologne, Cologne, Germany (YZ, CJB); Department of Community Medicine, University Medicine Greifswald, Greifswald, Germany (TKo); Department of General, Visceral, and Transplant Surgery, Ludwig-Maximilians-University Munich, Munich, Germany (JW, JGD); Department of General, Visceral and Transplantation Surgery, University of Heidelberg, Heidelberg, Germany (JPN, MWB); German Cancer Consortium, German Cancer Research Center, Heidelberg, Germany (TKi, VH, SB).

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February 2020

Author Correction: A randomised controlled trial of rosuvastatin for the prevention of aminoglycoside-induced kidney toxicity in children with cystic fibrosis.

Sci Rep 2020 Mar 10;10(1):4730. Epub 2020 Mar 10.

Department of Molecular and Clinical Pharmacology, and MRC Centre for Drug Safety Science, University of Liverpool, Liverpool, Merseyside, United Kingdom.

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March 2020

Early detection of pancreatic cancer.

Lancet Gastroenterol Hepatol 2020 07 2;5(7):698-710. Epub 2020 Mar 2.

Department of Molecular and Clinical Cancer Medicine, Institute of Translational Medicine, University of Liverpool, UK. Electronic address:

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July 2020

A randomised controlled trial of rosuvastatin for the prevention of aminoglycoside-induced kidney toxicity in children with cystic fibrosis.

Sci Rep 2020 02 4;10(1):1796. Epub 2020 Feb 4.

Department of Molecular and Clinical Pharmacology, and MRC Centre for Drug Safety Science, University of Liverpool, Liverpool, Merseyside, United Kingdom.

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February 2020

Natural history of SPINK1 germline mutation related-pancreatitis.

EBioMedicine 2019 Oct 15;48:581-591. Epub 2019 Oct 15.

Department of Gastroenterology and Pancreatology, Beaujon Hospital, APHP, Clichy, and Paris-Diderot University, Paris, France. Electronic address:

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October 2019

Pancreas-specific plasma amylase for assessment and diagnosis of chronic pancreatitis: New insights on an old topic.

United European Gastroenterol J 2019 08 16;7(7):955-964. Epub 2019 Apr 16.

Centre for Pancreatic Diseases, Department of Gastroenterology and Hepatology, Aalborg University Hospital, Aalborg, Denmark.

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August 2019

Increased plasma levels of galectin-1 in pancreatic cancer: potential use as biomarker.

Oncotarget 2018 Aug 31;9(68):32984-32996. Epub 2018 Aug 31.

Cancer Research Program, IMIM, Hospital del Mar Medical Research Institute, Unidad Asociade CSIC, Barcelona, Spain.

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August 2018

Therapeutic developments in pancreatic cancer: current and future perspectives.

Nat Rev Gastroenterol Hepatol 2018 06;15(6):333-348

Department of Molecular and Clinical Cancer Medicine, Institute of Translational Medicine, University of Liverpool, Liverpool, UK.

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June 2018

Designing a bio-inspired biomimetic in vitro system for the optimization of ex vivo studies of pancreatic cancer.

Drug Discov Today 2017 04 30;22(4):690-701. Epub 2017 Jan 30.

Bioprocess and Biochemical Engineering Group (BioProChem), Department of Chemical and Process Engineering, University of Surrey, Guildford GU2 7XH, UK. Electronic address:

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April 2017

Immunobiological effects of gemcitabine and capecitabine combination chemotherapy in advanced pancreatic ductal adenocarcinoma.

Br J Cancer 2016 Mar 4;114(5):510-8. Epub 2016 Feb 4.

National Institutes of Health Research Liverpool Pancreas Biomedical Research Unit and Clinical Directorate of General Surgery, Royal Liverpool and Broadgreen University Hospitals NHS Trust and the University of Liverpool, Liverpool L69 3GA, UK.

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March 2016

Choline Kinase Alpha (CHKα) as a Therapeutic Target in Pancreatic Ductal Adenocarcinoma: Expression, Predictive Value, and Sensitivity to Inhibitors.

Mol Cancer Ther 2016 Feb 14;15(2):323-33. Epub 2016 Jan 14.

Epithelial Carcinogenesis Group, Cancer Cell Biology Programme, Spanish National Cancer Research Center-CNIO, Madrid, Spain. Departament de Ciències Experimentals i de la Salut, Universitat Pompeu Fabra, Barcelona, Spain.

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February 2016

Single-Nucleotide Polymorphism to Associate Cancer Risk.

Methods Mol Biol 2016 ;1381:93-110

NIHR Pancreatic Biomedical Research Unit, Molecular and Clinical Cancer Medicine, Royal Liverpool University Hospital, 5th Floor UCD Block, Daulby Street, Liverpool, L69 3GA, UK.

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October 2016

Xanthogranulomatous pancreatitis associated with a mucinous cystic neoplam.

Pathol Int 2016 03 12;66(3):174-176. Epub 2015 Nov 12.

National Institute for Health Research Liverpool Pancreas Biomedical Research Unit, Liverpool, UK.

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March 2016

Inhibition of CD47 Effectively Targets Pancreatic Cancer Stem Cells via Dual Mechanisms.

Clin Cancer Res 2015 May 23;21(10):2325-37. Epub 2015 Feb 23.

Stem Cells and Cancer Group, Molecular Pathology Programme, Spanish National Cancer Research Centre (CNIO), Madrid, Spain. Centre for Stem Cells in Cancer and Ageing, Barts Cancer Institute, A CR-UK Centre of Excellence, Queen Mary University of London, United Kingdom.

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May 2015

Pancreatic mass in a young CFTR carrier with a heterozygous p.R117H CFTR gene mutation and homozygous 7T.

Pancreas 2015 Mar;44(2):343-5

National Institute for Health Research Liverpool Pancreas Biomedical Research Unit Royal Liverpool University Hospital Liverpool, UK Department of Cellular Pathology Royal Liverpool University Hospital Liverpool, UK National Institute for Health Research Liverpool Pancreas Biomedical Research Unit Royal Liverpool University Hospital Liverpool, UK National Institute for Health Research Liverpool Pancreas Biomedical Research Unit Royal Liverpool University Hospital Liverpool, UK

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March 2015

Incidence of post-ERCP pancreatitis from direct pancreatic juice collection in hereditary pancreatitis and familial pancreatic cancer before and after the introduction of prophylactic pancreatic stents and rectal diclofenac.

Pancreas 2015 Mar;44(2):260-5

From the *National Institute for Health Research Liverpool Pancreas Biomedical Research Unit, Royal Liverpool University Hospital; †Liverpool Clinical Trials Unit; Departments of ‡Gastroenterology, and §Radiology, Royal Liverpool University Hospital, Liverpool; and ║Digestive Diseases Biomedical Research Unit, National Institute for Health Research Nottingham, Queen's Medical Centre, Nottingham, United Kingdom.

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March 2015

Biomarkers for early diagnosis of pancreatic cancer.

Expert Rev Gastroenterol Hepatol 2015 Mar 6;9(3):305-15. Epub 2014 Nov 6.

Department of Molecular and Clinical Cancer Medicine, National Institute for Health Research Liverpool Pancreas Biomedical Research Unit, University of Liverpool, Daulby Street, Liverpool L69 3GA, UK.

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March 2015

Serum cytokine biomarker panels for discriminating pancreatic cancer from benign pancreatic disease.

Mol Cancer 2014 May 20;13:114. Epub 2014 May 20.

NIHR Liverpool Pancreas Biomedical Research Unit, Royal Liverpool and Broadgreen University Hospital NHS Trust, Department of Molecular and Clinical Cancer Medicine, University of Liverpool, Liverpool L69 3GA, UK.

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May 2014

Pancreatic cancer hENT1 expression and survival from gemcitabine in patients from the ESPAC-3 trial.

J Natl Cancer Inst 2014 Jan 3;106(1):djt347. Epub 2013 Dec 3.

Affiliations of authors: Liverpool Cancer Research UK Cancer Trials Unit, Liverpool Cancer Research UK Centre, University of Liverpool, Liverpool, UK (WG, JPN, EG, TFC, PG, EC, CMH, CLR, FC, RJ); the Princess Margaret Hospital, Toronto, Canada (MJM); Manchester Academic Health Sciences Centre, Christie NHS Foundation Trust, School of Cancer and Enabling Sciences, University of Manchester, UK (JWV); Queen Elizabeth Hospital, University Hospital Birmingham NHS Foundation Trust, Birmingham, UK (DHP); Beatson West of Scotland Cancer Centre, Glasgow, UK (ACM); Glasgow Royal Infirmary, Glasgow, UK (RC); Hôpital Tenon, Université, Pierre et Marie Curie, Paris, France (FL); Austin Health, Melbourne, Australia (NCT); Prince of Wales Hospital and Clinical School University of New South Wales, New South Wales, Australia (DG); Nepean Cancer Centre and University of Sydney, Sydney, Australia (JS); Agia Olga Hospital, Athens, Greece (CD); Medical Oncology, Clatterbridge Centre for Oncology, Bebington, Merseyside, UK (DS); Department of Oncology, Akademiska Sjukhuset, Uppsala University, Uppsala, Sweden (BG); University Hospital, North Staffordshire, UK (MD); Freeman Hospital, Newcastle upon Tyne, UK (RMC); Service de Chirurgie Digestive et Viscérale, Hôpital Tenon, Paris, France (FL); Cross Cancer Institute and University of Alberta, Alberta, Canada (JRM, AGS); Churchill Hospital, Oxford University Hospitals NHS Trust, Oxford, UK (MRM); St James's University Hospital, Leeds, UK (AA); Department of Medicine A, University Medicine Greifswald, Greifswald, Germany (JM); Petz Aladar Hospital, Gyor, Hungary (AO); Departments of Surgery and Pathology and ARC-NET Research Center, University of Verona, Italy (AS, CB); Department of Surgery, University of Heidelberg, Heidelberg, Germany (MWB).

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January 2014

Fatty acid ethyl ester synthase inhibition ameliorates ethanol-induced Ca2+-dependent mitochondrial dysfunction and acute pancreatitis.

Gut 2014 Aug 25;63(8):1313-24. Epub 2013 Oct 25.

Department of Cellular & Molecular Physiology, Institute of Translational Medicine, University of Liverpool, Liverpool, Merseyside, UK NIHR Liverpool Pancreas Biomedical Research Unit, RLBUHT, Institute of Translational Medicine, University of Liverpool, Liverpool, Merseyside, UK.

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August 2014

New biomarkers and targets in pancreatic cancer and their application to treatment.

Nat Rev Gastroenterol Hepatol 2012 Aug 26;9(8):435-44. Epub 2012 Jun 26.

National Institute for Health Research Pancreas Biomedical Research Unit and Liverpool Cancer Research UK Centre, Department of Molecular, University of Liverpool, Liverpool, L69 3GA, UK.

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August 2012

Combination therapy for the treatment of pancreatic cancer.

Anticancer Agents Med Chem 2011 Jun;11(5):418-26

Department of Molecular and Clinical Cancer Medicine, the University of Liverpool, UK.

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June 2011

Single-nucleotide polymorphism (SNP) analysis to associate cancer risk.

Methods Mol Biol 2010 ;576:171-96

Division of Surgery and Oncology, University of Liverpool, Liverpool, UK.

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January 2010

New treatment options for advanced pancreatic cancer.

Expert Rev Gastroenterol Hepatol 2008 Oct;2(5):673-96

Royal Surrey County Hospital NHS Trust, Egerton Road, Guildford, GU2 7XX, UK.

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October 2008

International registries of families at high risk of pancreatic cancer.

Pancreatology 2008 26;8(6):558-65. Epub 2008 Sep 26.

Division of Surgery, University of Liverpool, Royal Liverpool University Hospital, Liverpool, UK.

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December 2008

Trypsinogen mutations in pancreatic disorders.

Endocrinol Metab Clin North Am 2006 Jun;35(2):271-87, viii

Division of Surgery and Oncology, The University of Liverpool, 5th Floor UCD Building, Daulby Street, Liverpool, L69 3GA, United Kingdom.

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June 2006

The inherited genetics of pancreatic cancer and prospects for secondary screening.

Best Pract Res Clin Gastroenterol 2006 Apr;20(2):253-83

The University of Liverpool, Division of Surgery and Oncology, 5th Floor UCD, Daulby Street, Liverpool L69 3GA, UK.

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April 2006

Increased risk of idiopathic chronic pancreatitis in cystic fibrosis carriers.

Hum Mutat 2005 Oct;26(4):303-7

Department of Medicine, Durham Veterans Administration and Duke University Medical Center, Durham, North Carolina 27710, USA.

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October 2005

Cationic trypsinogen mutations and pancreatitis.

Clin Lab Med 2005 Mar;25(1):39-59

Department of Surgery and Oncology, University of Liverpool, 5th Floor, University Clinical Department Building, Daulby Street, Liverpool, L69 3GA, United Kingdom.

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March 2005

Cationic trypsinogen mutations and pancreatitis.

Gastroenterol Clin North Am 2004 Dec;33(4):767-87

Department of Surgery, Liverpool University, 5th Floor, University Clinical Department Building, Daulby Street, Liverpool, L69 3GA, United Kingdom.

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December 2004

No evidence for germline mutations of the LKB1/STK11 gene in familial pancreatic carcinoma.

Cancer Lett 2004 Oct;214(1):63-8

Department of Visceral, Thoracic and Vascular Surgery, University Hospital Carl Gustav Carus, Technical University of Dresden, Fetscherstrasse 74, 01307 Dresden, Germany.

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October 2004