William G Richards

William G Richards

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William G Richards

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Autophagy facilitates the release of immunogenic signals following chemotherapy in 3D models of mesothelioma.

Mol Carcinog 2019 Oct 19;58(10):1754-1769. Epub 2019 Jun 19.

Department of Medicine, Zuckerberg San Francisco General Hospital and Trauma Center, University of California San Francisco, San Francisco, California.

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http://dx.doi.org/10.1002/mc.23050DOI Listing
October 2019

Diagnostic value of biopsy sampling in predicting histology in patients with diffuse malignant pleural mesothelioma.

Cancer 2019 Aug 7. Epub 2019 Aug 7.

Department of Thoracic Surgery, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1002/cncr.32416DOI Listing
August 2019

Autophagy in 3D In Vitro and Ex Vivo Cancer Models.

Methods Mol Biol 2019 ;1880:491-510

Zuckerberg San Francisco General Hospital and Trauma Center, University of California San Francisco, San Francisco, CA, USA.

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http://link.springer.com/10.1007/978-1-4939-8873-0_31
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http://dx.doi.org/10.1007/978-1-4939-8873-0_31DOI Listing
June 2019

Calcimimetics maintain bone turnover in uremic rats despite the concomitant decrease in parathyroid hormone concentration.

Kidney Int 2019 May 12;95(5):1064-1078. Epub 2019 Mar 12.

Maimonides Institute for Biomedical Research (IMIBIC), Cordoba, Spain; Nephrology Service, Reina Sofia University Hospital, Cordoba, Spain; University of Cordoba, Cordoba, Spain; Spanish Renal Research Network (REDinREN), Institute of Health Carlos III, Madrid, Spain.

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http://dx.doi.org/10.1016/j.kint.2018.12.015DOI Listing
May 2019

FGF23 impairs peripheral microvascular function in renal failure.

Am J Physiol Heart Circ Physiol 2018 11 20;315(5):H1414-H1424. Epub 2018 Jul 20.

Department of Nephrology and Institute for Cardiovascular Research VU, VU University Medical Center , Amsterdam , The Netherlands.

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https://www.physiology.org/doi/10.1152/ajpheart.00272.2018
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http://dx.doi.org/10.1152/ajpheart.00272.2018DOI Listing
November 2018

A Phase I Trial of Surgical Resection and Intraoperative Hyperthermic Cisplatin and Gemcitabine for Pleural Mesothelioma.

J Thorac Oncol 2018 09 9;13(9):1400-1409. Epub 2018 May 9.

Department of Surgery, Division of General Thoracic Surgery, Baylor College of Medicine, Houston, Texas. Electronic address:

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http://dx.doi.org/10.1016/j.jtho.2018.04.032DOI Listing
September 2018

A systematic dissection of sequence elements determining β-Klotho and FGF interaction and signaling.

Sci Rep 2018 07 23;8(1):11045. Epub 2018 Jul 23.

Department of Cardiometabolic Disorders, Amgen Discovery Research, Amgen Inc., 1120 Veterans Blvd., South San Francisco, CA, 94080, USA.

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http://dx.doi.org/10.1038/s41598-018-29396-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6056499PMC
July 2018

Inhibition of autophagy initiation potentiates chemosensitivity in mesothelioma.

Mol Carcinog 2018 03 14;57(3):319-332. Epub 2017 Nov 14.

Zuckerberg San Francisco General Hospital and Trauma Center, University of California San Francisco, San Francisco, California.

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http://dx.doi.org/10.1002/mc.22757DOI Listing
March 2018

Quantitative Clinical Staging for Patients With Malignant Pleural Mesothelioma.

J Natl Cancer Inst 2018 03;110(3):258-264

Division of Thoracic Surgery, Brigham and Women's, Hospital and Harvard Medical School, Boston, MA.

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http://dx.doi.org/10.1093/jnci/djx175DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6009654PMC
March 2018

Profiling of PD-1 Blockade Using Organotypic Tumor Spheroids.

Cancer Discov 2018 02 3;8(2):196-215. Epub 2017 Nov 3.

Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.

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http://dx.doi.org/10.1158/2159-8290.CD-17-0833DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5809290PMC
February 2018

Etelcalcetide, A Novel Calcimimetic, Prevents Vascular Calcification in A Rat Model of Renal Insufficiency with Secondary Hyperparathyroidism.

Calcif Tissue Int 2017 12 16;101(6):641-653. Epub 2017 Oct 16.

Departments of Cardiometabolic Disorders and Comparative Biology and Safety Sciences, Amgen Inc., One Amgen Center Drive, MS: 36-2-A, Thousand Oaks, CA, 91320, USA.

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http://dx.doi.org/10.1007/s00223-017-0319-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5660836PMC
December 2017

Malignant pleural mesothelioma: predictors and staging.

Ann Transl Med 2017 Jun;5(11):243

Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.21037/atm.2017.06.26DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5497102PMC
June 2017

Chronic Over-expression of Fibroblast Growth Factor 21 Increases Bile Acid Biosynthesis by Opposing FGF15/19 Action.

EBioMedicine 2017 Feb 24;15:173-183. Epub 2016 Dec 24.

Amgen Inc., 1120 Veterans Blvd., South San Francisco, CA 94080, United States. Electronic address:

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http://dx.doi.org/10.1016/j.ebiom.2016.12.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5233823PMC
February 2017

Validation of a Gene Expression Test for Mesothelioma Prognosis in Formalin-Fixed Paraffin-Embedded Tissues.

J Mol Diagn 2017 01 15;19(1):65-71. Epub 2016 Nov 15.

Thoracic Surgery Oncology Laboratory and the International Mesothelioma Program, Division of Thoracic Surgery, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts. Electronic address:

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http://dx.doi.org/10.1016/j.jmoldx.2016.07.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5225306PMC
January 2017

Perioperative Ischemic Optic Neuropathy Following Extrapleural Pneumonectomy.

J Cardiothorac Vasc Anesth 2016 Dec 7;30(6):1645-1648. Epub 2016 Jan 7.

Departments of ⁎Anesthesiology, Perioperative and Pain Medicine.

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http://dx.doi.org/10.1053/j.jvca.2016.01.002DOI Listing
December 2016

North American Multicenter Volumetric CT Study for Clinical Staging of Malignant Pleural Mesothelioma: Feasibility and Logistics of Setting Up a Quantitative Imaging Study.

J Thorac Oncol 2016 08 12;11(8):1335-1344. Epub 2016 May 12.

Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York; Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5075991PMC
http://dx.doi.org/10.1016/j.jtho.2016.04.027DOI Listing
August 2016

Analysis of Gene Expression in 3D Spheroids Highlights a Survival Role for ASS1 in Mesothelioma.

PLoS One 2016 16;11(3):e0150044. Epub 2016 Mar 16.

Department of Medicine, Pulmonary, San Francisco General Hospital, University of California San Francisco, San Francisco, California, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0150044PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4794185PMC
July 2016

Autophagy initiation correlates with the autophagic flux in 3D models of mesothelioma and with patient outcome.

Autophagy 2016 07 20;12(7):1180-94. Epub 2016 Apr 20.

a San Francisco General Hospital, University of California San Francisco , San Francisco , CA , USA.

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http://dx.doi.org/10.1080/15548627.2016.1173799DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4990992PMC
July 2016

Parathyroid hormone activates the orphan nuclear receptor Nurr1 to induce FGF23 transcription.

Kidney Int 2014 Dec 18;86(6):1106-15. Epub 2014 Jun 18.

Department of Nephrology, Hadassah Hebrew University Medical Center, Jerusalem, Israel.

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http://dx.doi.org/10.1038/ki.2014.215DOI Listing
December 2014

Identification of recurrent FGFR3-TACC3 fusion oncogenes from lung adenocarcinoma.

Clin Cancer Res 2014 Dec 7;20(24):6551-8. Epub 2014 Oct 7.

Lowe Center for Thoracic Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts. Belfer Institute for Applied Cancer Science, Dana-Farber Cancer Institute, Boston, Massachusetts.

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http://dx.doi.org/10.1158/1078-0432.CCR-14-1337DOI Listing
December 2014

Inhibition of secreted frizzled-related protein 5 improves glucose metabolism.

Am J Physiol Endocrinol Metab 2014 Dec 4;307(12):E1144-52. Epub 2014 Nov 4.

Amgen Incorporated, South San Francisco, California; and

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http://dx.doi.org/10.1152/ajpendo.00283.2014DOI Listing
December 2014

Extrapleural pneumonectomy in the treatment of epithelioid malignant pleural mesothelioma: novel prognostic implications of combined N1 and N2 nodal involvement based on experience in 529 patients.

Ann Surg 2014 Oct;260(4):577-80; discussion 580-2

*Debakey Department of Surgery, Baylor College of Medicine, Houston, TX; and †Division of Thoracic Surgery, Brigham and Women's Hospital, Boston, MA.

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http://dx.doi.org/10.1097/SLA.0000000000000903DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4481127PMC
October 2014

Gene expression ratio test distinguishes normal lung from lung tumors in solid tissue and FNA biopsies.

J Mol Diagn 2014 Mar 9;16(2):267-72. Epub 2014 Jan 9.

Thoracic Surgery Oncology Laboratory and the International Mesothelioma Program, Division of Thoracic Surgery, Brigham and Women's Hospital, Boston, Massachusetts; Department of Surgery, Harvard Medical School, Boston, Massachusetts. Electronic address:

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http://dx.doi.org/10.1016/j.jmoldx.2013.11.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3937535PMC
March 2014

Clinical indications and results after chest wall resection for recurrent mesothelioma.

J Thorac Cardiovasc Surg 2013 Dec 8;146(6):1373-9; discussion 1379-80. Epub 2013 Oct 8.

Department of Cardiothoracic Surgery, Stanford University Medical School, Stanford, Calif.

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http://dx.doi.org/10.1016/j.jtcvs.2013.07.012DOI Listing
December 2013

Clinicopathologic characteristics of malignant mesotheliomas arising in patients with a history of radiation for Hodgkin and non-Hodgkin lymphoma.

J Clin Oncol 2013 Dec 18;31(36):4544-9. Epub 2013 Nov 18.

Lucian R. Chirieac, Justine A. Barletta, William G. Richards, Tamara Tilleman, Raphael Bueno, Elizabeth H. Baldini, John Godleski, and David J. Sugarbaker, Brigham and Women's Hospital; Beow Y. Yeap, Massachusetts General Hospital; and William G. Richards, Tamara Tilleman, Raphael Bueno, Elizabeth H. Baldini, and David J. Sugarbaker, Harvard Medical School, Boston, MA.

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http://dx.doi.org/10.1200/JCO.2013.49.9616DOI Listing
December 2013

The calcium sensing receptor modulates fluid reabsorption and acid secretion in the proximal tubule.

Kidney Int 2013 Aug 24;84(2):277-84. Epub 2013 Apr 24.

Department of Nephrology, Second University of Naples, Naples, Italy.

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http://dx.doi.org/10.1038/ki.2013.137DOI Listing
August 2013

Sequential binary gene ratio tests define a novel molecular diagnostic strategy for malignant pleural mesothelioma.

Clin Cancer Res 2013 May 14;19(9):2493-502. Epub 2013 Mar 14.

The Thoracic Surgery Oncology Laboratory, and International Mesothelioma Program, Division of Thoracic Surgery, Brigham and Women's Hospital, and Harvard Medical School, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1158/1078-0432.CCR-12-2117DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3644001PMC
May 2013

Sclerostin and Dickkopf-1 as therapeutic targets in bone diseases.

Endocr Rev 2012 Oct 20;33(5):747-83. Epub 2012 Jun 20.

Metabolic Disorders Research, Amgen Inc., One Amgen Center Drive, MS 29-M-B, Thousand Oaks, California 91320, USA.

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http://dx.doi.org/10.1210/er.2011-1060DOI Listing
October 2012

Epithelial malignant pleural mesothelioma after extrapleural pneumonectomy: stratification of survival with CT-derived tumor volume.

AJR Am J Roentgenol 2012 Feb;198(2):359-63

Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, 75 Francis St, Boston, MA 02115, USA.

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http://dx.doi.org/10.2214/AJR.11.7015DOI Listing
February 2012

A gene expression ratio-based diagnostic test for bladder cancer.

Adv Appl Bioinform Chem 2009 12;2:17-22. Epub 2009 Jan 12.

The Thoracic Surgery Oncology laboratory and the Division of Thoracic Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3169945PMC
November 2011

Human Dickkopf-1 (huDKK1) protein: characterization of glycosylation and determination of disulfide linkages in the two cysteine-rich domains.

Protein Sci 2011 Nov 27;20(11):1802-13. Epub 2011 Sep 27.

Department of Protein Sciences, Amgen, Inc., One Amgen Center Dr., Thousand Oaks, California 91320, USA.

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http://doi.wiley.com/10.1002/pro.705
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http://dx.doi.org/10.1002/pro.705DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3267945PMC
November 2011

Lobectomy versus sublobar resection for small (2 cm or less) non-small cell lung cancers.

Ann Thorac Surg 2011 Nov 31;92(5):1819-23; discussion 1824-5. Epub 2011 Oct 31.

Division of Thoracic Surgery, Brigham and Women's Hospital, Boston, Massachusetts 02215, USA.

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http://dx.doi.org/10.1016/j.athoracsur.2011.06.099DOI Listing
November 2011

Clinical and pathological features of three-year survivors of malignant pleural mesothelioma following extrapleural pneumonectomy.

Eur J Cardiothorac Surg 2011 Aug 9;40(2):298-303. Epub 2011 Feb 9.

Division of Thoracic Surgery and Department of Pathology, Brigham and Women's Hospital, Boston, MA, USA.

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http://dx.doi.org/10.1016/j.ejcts.2010.12.024DOI Listing
August 2011

Fine-needle aspiration biopsies for gene expression ratio-based diagnostic and prognostic tests in malignant pleural mesothelioma.

Clin Cancer Res 2011 Jan 18;17(2):310-6. Epub 2010 Nov 18.

The Thoracic Surgery Oncology Laboratory and International Mesothelioma Program, and Division of Thoracic Surgery, Brigham and Women's Hospital, and Harvard Medical School, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1158/1078-0432.CCR-10-0806DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3058309PMC
January 2011

Resident memory T cells (T(RM)) are abundant in human lung: diversity, function, and antigen specificity.

PLoS One 2011 Jan 26;6(1):e16245. Epub 2011 Jan 26.

Department of Dermatology, Brigham and Women's Hospital, Harvard Skin Disease Research Center, Boston, Massachusetts, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0016245PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3027667PMC
January 2011

Characteristics of malignant pleural mesothelioma in women.

Ann Thorac Surg 2010 Sep;90(3):949-56; discussion 956

Division of Thoracic Surgery, Brigham and Women's Hospital, Boston, Massachusetts 02215, USA.

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http://dx.doi.org/10.1016/j.athoracsur.2010.04.110DOI Listing
September 2010

Prevalence of in vitro chemotherapeutic drug resistance in primary malignant pleural mesothelioma: result in a cohort of 203 resection specimens.

J Thorac Cardiovasc Surg 2010 Aug;140(2):352-5

Division of Thoracic Surgery, Department of Surgery, Brigham and Women's Hospital, Boston, MA 02115, USA.

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http://dx.doi.org/10.1016/j.jtcvs.2009.11.072DOI Listing
August 2010

Managing the pneumonectomy space after extrapleural pneumonectomy: postoperative intrathoracic pressure monitoring.

Eur J Cardiothorac Surg 2010 Apr 6;37(4):770-5. Epub 2010 Jan 6.

Division of Thoracic Surgery and Department of Radiology, Brigham and Women's Hospital, Boston, MA 02215, USA.

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http://dx.doi.org/10.1016/j.ejcts.2009.10.020DOI Listing
April 2010

Recent advances in mesothelioma staging.

Semin Thorac Cardiovasc Surg 2009 ;21(2):105-10

Division of Thoracic Surgery, Harvard Medical School, Brigham and Women's Hospital, BWH Tissue and Blood Repository, Boston, Massachusetts 02115, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S104306790900077
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http://dx.doi.org/10.1053/j.semtcvs.2009.07.002DOI Listing
December 2009

Identification of small molecule inhibitors of proline-rich tyrosine kinase 2 (Pyk2) with osteogenic activity in osteoblast cells.

Bioorg Med Chem Lett 2009 Sep 22;19(17):4924-8. Epub 2009 Jul 22.

Chemistry Research & Discovery, Amgen Inc., One Amgen Center Drive, Thousand Oaks, CA 91320, USA.

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http://dx.doi.org/10.1016/j.bmcl.2009.07.084DOI Listing
September 2009

Four-gene expression ratio test for survival in patients undergoing surgery for mesothelioma.

J Natl Cancer Inst 2009 May 28;101(9):678-86. Epub 2009 Apr 28.

Department of Surgery, Division of Thoracic Surgery, Harvard Medical School and Brigham and Women's Hospital, 75 Francis St, Boston, MA 02115, USA.

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http://dx.doi.org/10.1093/jnci/djp061DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2677573PMC
May 2009

Morbidity, mortality, mean survival, and the impact of histology on survival after pleurectomy in 64 patients with malignant pleural mesothelioma.

Int J Surg 2008 Aug 1;6(4):293-7. Epub 2008 May 1.

Department of Surgery, Cardiothoracic Surgery, Boston University Medical Center, School of Medicine, One Boston Medical Center Place, Boston MA 02118, USA.

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http://dx.doi.org/10.1016/j.ijsu.2008.04.004DOI Listing
August 2008

Transcriptome sequencing of malignant pleural mesothelioma tumors.

Proc Natl Acad Sci U S A 2008 Mar 26;105(9):3521-6. Epub 2008 Feb 26.

International Mesothelioma Program, Division of Thoracic Surgery, Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA.

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http://dx.doi.org/10.1073/pnas.0712399105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2265129PMC
March 2008

Dickkopf-1 is a master regulator of joint remodeling.

Nat Med 2007 Feb 21;13(2):156-63. Epub 2007 Jan 21.

Department of Internal Medicine 3 and Institute for Clinical Immunology, University of Erlangen-Nurnberg, Krankenhausstrasse 12, D-91054 Erlangen, Germany.

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http://dx.doi.org/10.1038/nm1538DOI Listing
February 2007

Nodal downstaging predicts survival following induction chemotherapy for stage IIIA (N2) non-small cell lung cancer in CALGB protocol #8935.

J Surg Oncol 2006 Dec;94(7):599-606

Division of Thoracic Surgery, Brigham and Women's Hospital, Dana-Farber Cancer Institute, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1002/jso.20644DOI Listing
December 2006

Cocaine- and amphetamine-regulated transcript (CART) peptides modulate the locomotor and motivational properties of psychostimulants.

J Pharmacol Exp Ther 2005 Dec 11;315(3):1091-100. Epub 2005 Aug 11.

Department of Cellular and Molecular Pharmacology, Rosalind Franklin University of Medicine and Science/Chicago Medical School, North Chicago, IL 60064, USA.

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http://dx.doi.org/10.1124/jpet.105.091678DOI Listing
December 2005

Validation of genomics-based prognostic tests in malignant pleural mesothelioma.

Clin Cancer Res 2005 Jun;11(12):4406-14

Thoracic Surgery Oncology Laboratory and Division of Thoracic Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1158/1078-0432.CCR-04-2181DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1488818PMC
June 2005

Leptin regulation of bone resorption by the sympathetic nervous system and CART.

Nature 2005 Mar 20;434(7032):514-20. Epub 2005 Feb 20.

Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA.

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http://dx.doi.org/10.1038/nature03398DOI Listing
March 2005

Obesity and diabetes in transgenic mice expressing proSAAS.

J Endocrinol 2004 Mar;180(3):357-68

Department of Molecular Pharmacology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, New York 10461, USA.

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http://dx.doi.org/10.1677/joe.0.1800357DOI Listing
March 2004

Impaired coordination of nutrient intake and substrate oxidation in melanocortin-4 receptor knockout mice.

Endocrinology 2004 Jan 9;145(1):243-52. Epub 2003 Oct 9.

Pennington Biomedical Research Center/Louisiana State University, Baton Rouge, Louisiana 70808, USA.

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http://dx.doi.org/10.1210/en.2003-0452DOI Listing
January 2004

A prognostic test for adenocarcinoma of the lung from gene expression profiling data.

Cancer Epidemiol Biomarkers Prev 2003 Sep;12(9):905-10

Division of Thoracic Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA.

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September 2003

Gene expression in lung adenocarcinomas of smokers and nonsmokers.

Am J Respir Cell Mol Biol 2003 Aug 21;29(2):157-62. Epub 2003 Feb 21.

Department of Medicine, Columbia College of Physicians and Surgeons, New York, New York, USA.

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http://dx.doi.org/10.1165/rcmb.2002-0183RCDOI Listing
August 2003

Loss of the Tg737 protein results in skeletal patterning defects.

Dev Dyn 2003 May;227(1):78-90

The University of Alabama at Birmingham, Department of Cell Biology, Birmingham, Alabama 35294, USA.

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http://dx.doi.org/10.1002/dvdy.10289DOI Listing
May 2003

Using gene expression ratios to predict outcome among patients with mesothelioma.

J Natl Cancer Inst 2003 Apr;95(8):598-605

Division of Thoracic Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1093/jnci/95.8.598DOI Listing
April 2003

Patterns of allelic loss differ in lung adenocarcinomas of smokers and nonsmokers.

Lung Cancer 2003 Jan;39(1):23-9

Department of Medicine, Columbia College of Physicians and Surgeons, New York, NY, USA.

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http://dx.doi.org/10.1016/s0169-5002(02)00384-7DOI Listing
January 2003