William G Kaelin

William G Kaelin

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William G Kaelin

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HIF-independent synthetic lethality between CDK4/6 inhibition and VHL loss across species.

Sci Signal 2019 10 1;12(601). Epub 2019 Oct 1.

Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02215, USA.

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http://dx.doi.org/10.1126/scisignal.aay0482DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6913182PMC
October 2019

Peptidic degron for IMiD-induced degradation of heterologous proteins.

Proc Natl Acad Sci U S A 2019 02 25;116(7):2539-2544. Epub 2019 Jan 25.

Department of Medical Oncology, Dana-Farber Cancer Institute and Brigham and Womens Hospital, Harvard Medical School, Boston, MA 02215;

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http://dx.doi.org/10.1073/pnas.1818109116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6377458PMC
February 2019

The VHL Tumor Suppressor Gene: Insights into Oxygen Sensing and Cancer.

Authors:
William G Kaelin

Trans Am Clin Climatol Assoc 2017 ;128:298-307

BOSTON, MASSACHUSETTS.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5525432PMC
May 2018

Senator McCain and Our Shared Humanity.

Authors:
William G Kaelin

Am J Med 2018 03 8;131(3):216-217. Epub 2017 Dec 8.

Department of Medical Oncology, Dana-Farber Cancer Institute, Brigham and Women's Hospital, Harvard Medical School, Boston, Mass; Howard Hughes Medical Institute, Chevy Chase, Md. Electronic address:

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http://dx.doi.org/10.1016/j.amjmed.2017.11.028DOI Listing
March 2018

HIF2 Inhibitor Joins the Kidney Cancer Armamentarium.

Authors:
William G Kaelin

J Clin Oncol 2018 03 31;36(9):908-910. Epub 2018 Jan 31.

William G. Kaelin Jr, Harvard Medical School, Boston, MA.

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http://dx.doi.org/10.1200/JCO.2017.77.5254DOI Listing
March 2018

Targeting HIF2 in Clear Cell Renal Cell Carcinoma.

Cold Spring Harb Symp Quant Biol 2016 8;81:113-121. Epub 2016 Dec 8.

Howard Hughes Medical Institute, Dana-Farber Cancer Institute and Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 022145.

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http://symposium.cshlp.org/lookup/doi/10.1101/sqb.2016.81.03
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http://dx.doi.org/10.1101/sqb.2016.81.030833DOI Listing
February 2018

Climate Change: What Would Lincoln Do?

Authors:
William G Kaelin

JAMA 2017 Aug;318(7):611

Howard Hughes Medical Institute, Chevy Chase, Maryland.

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http://jama.jamanetwork.com/article.aspx?doi=10.1001/jama.20
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http://dx.doi.org/10.1001/jama.2017.6999DOI Listing
August 2017

Common pitfalls in preclinical cancer target validation.

Authors:
William G Kaelin

Nat Rev Cancer 2017 07 19;17(7):425-440. Epub 2017 May 19.

Howard Hughes Medical Institute, Dana-Farber Cancer Institute and Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02215, USA.

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http://dx.doi.org/10.1038/nrc.2017.32DOI Listing
July 2017

The EGLN-HIF O-Sensing System: Multiple Inputs and Feedbacks.

Mol Cell 2017 Jun;66(6):772-779

Howard Hughes Medical Institute, Boston, MA 02215, USA; Dana-Farber Cancer Institute, Boston, MA 02215, USA; Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02215, USA.

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http://dx.doi.org/10.1016/j.molcel.2017.06.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5613951PMC
June 2017

Publish houses of brick, not mansions of straw.

Authors:
William G Kaelin

Nature 2017 05;545(7655):387

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http://dx.doi.org/10.1038/545387aDOI Listing
May 2017

Inactivation of the PBRM1 tumor suppressor gene amplifies the HIF-response in VHL-/- clear cell renal carcinoma.

Proc Natl Acad Sci U S A 2017 01 12;114(5):1027-1032. Epub 2017 Jan 12.

Department of Medical Oncology, Dana-Farber Cancer Institute and Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115;

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http://www.pnas.org/lookup/doi/10.1073/pnas.1619726114
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http://dx.doi.org/10.1073/pnas.1619726114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5293026PMC
January 2017

On-target efficacy of a HIF-2α antagonist in preclinical kidney cancer models.

Nature 2016 11 5;539(7627):107-111. Epub 2016 Sep 5.

Department of Medical Oncology, Dana-Farber Cancer Institute and Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02215, USA.

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http://dx.doi.org/10.1038/nature19795DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5499381PMC
November 2016

Pathways for Oxygen Regulation and Homeostasis: The 2016 Albert Lasker Basic Medical Research Award.

JAMA 2016 Sep;316(12):1252-3

McKusick-Nathans Institute of Genetic Medicine and Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland.

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http://dx.doi.org/10.1001/jama.2016.12386DOI Listing
September 2016

Paracrine Induction of HIF by Glutamate in Breast Cancer: EglN1 Senses Cysteine.

Cell 2016 Jun;166(1):126-39

Department of Medical Oncology, Dana-Farber Cancer Institute and Brigham and Women's Hospital, Boston, MA 02215, USA; Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2016.05.042DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4930557PMC
June 2016

Fumarate and Succinate Regulate Expression of Hypoxia-inducible Genes via TET Enzymes.

J Biol Chem 2016 Feb 23;291(8):4256-65. Epub 2015 Dec 23.

From the Biocenter Oulu, Faculty of Biochemistry and Molecular Medicine, Oulu Center for Cell-Matrix Research, University of Oulu, FIN-90014 Oulu, Finland,

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http://www.jbc.org/content/291/8/4256.full.pdf
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http://www.jbc.org/lookup/doi/10.1074/jbc.M115.688762
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http://dx.doi.org/10.1074/jbc.M115.688762DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4759199PMC
February 2016

EGLN1 Inhibition and Rerouting of α-Ketoglutarate Suffice for Remote Ischemic Protection.

Cell 2016 Feb;164(5):884-95

Harvard Medical School, Boston, MA 02115, USA; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2016.02.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4819986PMC
February 2016

EglN2 associates with the NRF1-PGC1α complex and controls mitochondrial function in breast cancer.

EMBO J 2015 Dec 22;34(23):2953-70. Epub 2015 Oct 22.

Lineberger Comprehensive Cancer Center, University of North Carolina School of Medicine, Chapel Hill, NC, USA Department of Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill, NC, USA

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http://dx.doi.org/10.15252/embj.201591437DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4687683PMC
December 2015

Peptidic degron in EID1 is recognized by an SCF E3 ligase complex containing the orphan F-box protein FBXO21.

Proc Natl Acad Sci U S A 2015 Dec 2;112(50):15372-7. Epub 2015 Dec 2.

Department of Medical Oncology, Dana-Farber Cancer Institute and Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02215; Howard Hughes Medical Institute, Chevy Chase, MD 20815

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http://dx.doi.org/10.1073/pnas.1522006112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4687553PMC
December 2015

Inhibition of the oxygen sensor PHD2 in the liver improves survival in lactic acidosis by activating the Cori cycle.

Proc Natl Acad Sci U S A 2015 Sep 31;112(37):11642-7. Epub 2015 Aug 31.

Department of Biochemistry, Keio University School of Medicine, Tokyo 160-8582, Japan; Japan Science and Technology Agency, Exploratory Research for Advanced Technology, Suematsu Gas Biology Project, Core Research for Evolutional Science and Technology, Tokyo 160-8582, Japan;

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http://dx.doi.org/10.1073/pnas.1515872112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4577207PMC
September 2015

DisABLing kidney cancers caused by fumarate hydratase mutations.

Authors:
William G Kaelin

Cancer Cell 2014 Dec;26(6):779-780

Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA; Department of Medical Oncology, Dana-Farber Cancer Institute and Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02215, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2014.11.022DOI Listing
December 2014

A genetic mechanism for Tibetan high-altitude adaptation.

Nat Genet 2014 Sep 17;46(9):951-6. Epub 2014 Aug 17.

1] Department of Medicine, University of Utah School of Medicine and George E. Wahlin Veterans Administration Medical Center, Salt Lake City, Utah, USA. [2] Eccles Institute of Human Genetics, University of Utah School of Medicine, Salt Lake City, Utah, USA. [3].

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http://dx.doi.org/10.1038/ng.3067DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4473257PMC
September 2014

Prolyl hydroxylation by EglN2 destabilizes FOXO3a by blocking its interaction with the USP9x deubiquitinase.

Genes Dev 2014 Jul;28(13):1429-44

Lineberger Comprehensive Cancer Center, University of North Carolina School of Medicine, Chapel Hill, North Carolina 27599, USA; Department of Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill, North Carolina 27599, USA.

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http://dx.doi.org/10.1101/gad.242131.114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4083087PMC
July 2014

SQSTM1 is a pathogenic target of 5q copy number gains in kidney cancer.

Cancer Cell 2013 Dec;24(6):738-50

Department of Medical Oncology, Dana-Farber Cancer Institute and Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA; Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA; Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccr.2013.10.025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3910168PMC
December 2013

What a difference a hydroxyl makes: mutant IDH, (R)-2-hydroxyglutarate, and cancer.

Genes Dev 2013 Apr;27(8):836-52

Department of Medical Oncology, Dana-Farber Cancer Institute, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02215, USA.

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http://dx.doi.org/10.1101/gad.217406.113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3650222PMC
April 2013

Influence of metabolism on epigenetics and disease.

Cell 2013 Mar;153(1):56-69

Department of Medical Oncology, Dana-Farber Cancer Institute and Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02215, USA.

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http://dx.doi.org/10.1016/j.cell.2013.03.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3775362PMC
March 2013

The VHL/HIF axis in clear cell renal carcinoma.

Semin Cancer Biol 2013 Feb 13;23(1):18-25. Epub 2012 Jun 13.

Howard Hughes Medical Insititute, Dana-Farber Cancer Institute and Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02215, United States.

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http://dx.doi.org/10.1016/j.semcancer.2012.06.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3663044PMC
February 2013

Coordinated repression of cell cycle genes by KDM5A and E2F4 during differentiation.

Proc Natl Acad Sci U S A 2012 Nov 23;109(45):18499-504. Epub 2012 Oct 23.

Department of Biochemistry and Molecular Genetics, University of Illinois, Chicago, IL 60607, USA.

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http://dx.doi.org/10.1073/pnas.1216724109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3494949PMC
November 2012

Molecular biology. Use and abuse of RNAi to study mammalian gene function.

Authors:
William G Kaelin

Science 2012 Jul;337(6093):421-2

Department of Adult Oncology, Office M457, Dana-Farber Cancer Institute, 450 Brookline Avenue, Boston, MA 02215, USA.

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http://www.sciencemag.org/cgi/doi/10.1126/science.1225787
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http://dx.doi.org/10.1126/science.1225787DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3705935PMC
July 2012

Transformation by the (R)-enantiomer of 2-hydroxyglutarate linked to EGLN activation.

Nature 2012 Feb 15;483(7390):484-8. Epub 2012 Feb 15.

Biocenter Oulu, Department of Medical Biochemistry and Molecular Biology, Oulu Center for Cell-Matrix Research, University of Oulu, FIN-90014 Oulu, Finland.

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http://www.nature.com/articles/nature10898
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http://dx.doi.org/10.1038/nature10898DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3656605PMC
February 2012

New insights into the biology of renal cell carcinoma.

Hematol Oncol Clin North Am 2011 Aug;25(4):667-86

Howard Hughes Medical Institute, 4000 Jones Bridge Road, Chevy Chase, MD 20815, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S08898588110004
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http://dx.doi.org/10.1016/j.hoc.2011.04.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3161447PMC
August 2011

Genetic and functional studies implicate HIF1α as a 14q kidney cancer suppressor gene.

Cancer Discov 2011 Aug 7;1(3):222-35. Epub 2011 Jun 7.

Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts 02215, USA.

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http://dx.doi.org/10.1158/2159-8290.CD-11-0098DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3202343PMC
August 2011

Good COP1 or bad COP1? In vivo veritas.

J Clin Invest 2011 Apr 14;121(4):1263-5. Epub 2011 Mar 14.

Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1172/JCI57080DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3069793PMC
April 2011

New cancer targets emerging from studies of the Von Hippel-Lindau tumor suppressor protein.

Authors:
William G Kaelin

Ann N Y Acad Sci 2010 Oct;1210:1-7

Howard Hughes Medical Institute, Dana-Farber Cancer Institute and Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1111/j.1749-6632.2010.05781.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4784475PMC
October 2010

Loss of hypoxia-inducible factor prolyl hydroxylase activity in cardiomyocytes phenocopies ischemic cardiomyopathy.

Circulation 2010 Sep 23;122(10):1004-16. Epub 2010 Aug 23.

Department of Medical Oncology, Dana-Farber Cancer Institute and Brigham and Women's Hospital, Harvard Medical School, 44 Binney St, Boston, MA 02115, USA.

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http://dx.doi.org/10.1161/CIRCULATIONAHA.109.922427DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2971656PMC
September 2010

Reactivation of hepatic EPO synthesis in mice after PHD loss.

Science 2010 Jul;329(5990):407

Howard Hughes Medical Institute, Dana-Farber Cancer Institute and Brigham and Women's Hospital, Boston, MA 02115, USA.

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http://dx.doi.org/10.1126/science.1192811DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3668543PMC
July 2010

Q&A: Cancer: clues from cell metabolism.

Nature 2010 Jun;465(7298):562-4

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http://dx.doi.org/10.1038/465562aDOI Listing
June 2010

Prostate cancer: beta control your hormones.

Cancer Cell 2010 Apr;17(4):311-2

Dana-Farber Cancer Institute, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1016/j.ccr.2010.03.013DOI Listing
April 2010

Slaying RAS with a synthetic lethal weapon.

Cell Res 2010 Feb;20(2):119-21

Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1038/cr.2010.16DOI Listing
February 2010

A feedback loop involving the Phd3 prolyl hydroxylase tunes the mammalian hypoxic response in vivo.

Mol Cell Biol 2009 Nov 31;29(21):5729-41. Epub 2009 Aug 31.

Department of Medical Oncology, Dana-Farber Cancer Institute and Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1128/MCB.00331-09DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2772748PMC
November 2009

Control of cyclin D1 and breast tumorigenesis by the EglN2 prolyl hydroxylase.

Cancer Cell 2009 Nov;16(5):413-24

Department of Medical Oncology, Dana-Farber Cancer Institute and Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1016/j.ccr.2009.09.029DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2788761PMC
November 2009

Synthetic lethality: a framework for the development of wiser cancer therapeutics.

Authors:
William G Kaelin

Genome Med 2009 Oct 27;1(10):99. Epub 2009 Oct 27.

Howard Hughes Medical Institute, Dana-Farber Cancer Institute and Brigham and Women's Hospital, 44 Binney St, Boston, MA 02115, USA.

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http://dx.doi.org/10.1186/gm99DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2784312PMC
October 2009

SDH5 mutations and familial paraganglioma: somewhere Warburg is smiling.

Authors:
William G Kaelin

Cancer Cell 2009 Sep;16(3):180-2

Howard Hughes Medical Institute, Dana-Farber Cancer Institute and Brigham and Women's Hospital, Boston, MA 02115, USA.

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http://dx.doi.org/10.1016/j.ccr.2009.08.013DOI Listing
September 2009

Treatment of kidney cancer: insights provided by the VHL tumor-suppressor protein.

Authors:
William G Kaelin

Cancer 2009 May;115(10 Suppl):2262-72

Howard Hughes Medical Institute, Dana-Farber Cancer Institute and Brigham and Women's Hospital, Harvard Medical School, 44 Binney Street, Mayer 457, Boston, MA 02115, USA.

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http://dx.doi.org/10.1002/cncr.24232DOI Listing
May 2009

Kidney cancer: now available in a new flavor.

Authors:
William G Kaelin

Cancer Cell 2008 Dec;14(6):423-4

Department of Medical Oncology, Dana-Farber Cancer Institute, Brigham and Women's Hospital, and Howard Hughes Medical Institute, Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1016/j.ccr.2008.11.005DOI Listing
December 2008

The von Hippel-Lindau tumour suppressor protein: O2 sensing and cancer.

Authors:
William G Kaelin

Nat Rev Cancer 2008 Nov 16;8(11):865-73. Epub 2008 Oct 16.

Howard Hughes Medical Institute, Chevy Chase, Maryland 20815-6789, USA.

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http://www.nature.com/articles/nrc2502
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http://dx.doi.org/10.1038/nrc2502DOI Listing
November 2008

A role for mammalian Sin3 in permanent gene silencing.

Mol Cell 2008 Nov;32(3):359-70

New York University School of Medicine, NYU Cancer Institute, 522 1st Avenue, New York, NY 10016, USA.

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http://dx.doi.org/10.1016/j.molcel.2008.10.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3100182PMC
November 2008

Kinase requirements in human cells: III. Altered kinase requirements in VHL-/- cancer cells detected in a pilot synthetic lethal screen.

Proc Natl Acad Sci U S A 2008 Oct 23;105(43):16484-9. Epub 2008 Oct 23.

Department of Medical Oncology, The Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA 02115, USA.

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http://www.pnas.org/cgi/doi/10.1073/pnas.0806574105
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http://dx.doi.org/10.1073/pnas.0806574105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2575446PMC
October 2008

Von Hippel-Lindau disease.

Authors:
William G Kaelin

Annu Rev Pathol 2007 ;2:145-73

Department of Medical Oncology, Dana-Farber Cancer Institute and Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1146/annurev.pathol.2.010506.092049DOI Listing
August 2008

Senescence triggered by the loss of the VHL tumor suppressor.

Cell Cycle 2008 Jun 16;7(12):1709-12. Epub 2008 Jun 16.

Department of Developmental and Stem Cell Biology, Joslin Diabetes Center, Harvard Medical School, Boston, Massachusetts 02215, USA.

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http://dx.doi.org/10.4161/cc.7.12.6124DOI Listing
June 2008

Oxygen sensing by metazoans: the central role of the HIF hydroxylase pathway.

Mol Cell 2008 May;30(4):393-402

Howard Hughes Medical Institute, Boston, MA 02115, USA.

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http://dx.doi.org/10.1016/j.molcel.2008.04.009DOI Listing
May 2008

Somatic inactivation of the PHD2 prolyl hydroxylase causes polycythemia and congestive heart failure.

Blood 2008 Mar 20;111(6):3236-44. Epub 2007 Dec 20.

Department of Medical Oncology, Brigham and Women's Hospital and Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1182/blood-2007-10-117812DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2265460PMC
March 2008

VHL loss actuates a HIF-independent senescence programme mediated by Rb and p400.

Nat Cell Biol 2008 Mar 24;10(3):361-9. Epub 2008 Feb 24.

Department of Medical Oncology, Dana-Farber Cancer Institute and Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1038/ncb1699DOI Listing
March 2008

The von hippel-lindau tumor suppressor protein: an update.

Authors:
William G Kaelin

Methods Enzymol 2007 ;435:371-83

Howard Hughes Medical Institute, Harvard Medical School, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1016/S0076-6879(07)35019-2DOI Listing
February 2008

Nineteenth Annual Pezcoller Symposium: hypothesis-driven clinical investigation in cancer.

Cancer Res 2007 Dec 28;67(23):11102-5. Epub 2007 Nov 28.

Dana-Farber Cancer Institute, Boston, Massachusetts, USA.

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http://cancerres.aacrjournals.org/lookup/doi/10.1158/0008-54
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http://dx.doi.org/10.1158/0008-5472.CAN-07-3230DOI Listing
December 2007

Hypoxia-inducible factor linked to differential kidney cancer risk seen with type 2A and type 2B VHL mutations.

Mol Cell Biol 2007 Aug 25;27(15):5381-92. Epub 2007 May 25.

Department of Medical Oncology, Dana-Farber Cancer Institute and Brigham and Women's Hospital, Harvard Medical School, 44 Binney Street, Mayer 457, Boston, MA 02115, USA.

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http://mcb.asm.org/cgi/doi/10.1128/MCB.00282-07
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http://dx.doi.org/10.1128/MCB.00282-07DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1952077PMC
August 2007

Bioluminescent imaging of ubiquitin ligase activity: measuring Cdk2 activity in vivo through changes in p27 turnover.

Methods Enzymol 2005 ;399:530-49

Howard Hughes Medical Institute, Dana-Farber Cancer Institute and Brighan and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S007668790599036
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http://dx.doi.org/10.1016/S0076-6879(05)99036-8DOI Listing
May 2007

The hypoxia-inducible factor 2alpha N-terminal and C-terminal transactivation domains cooperate to promote renal tumorigenesis in vivo.

Mol Cell Biol 2007 Mar 12;27(6):2092-102. Epub 2007 Jan 12.

Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA.

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http://mcb.asm.org/lookup/doi/10.1128/MCB.01514-06
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http://dx.doi.org/10.1128/MCB.01514-06DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1820491PMC
March 2007

The retinoblastoma binding protein RBP2 is an H3K4 demethylase.

Cell 2007 Mar 22;128(5):889-900. Epub 2007 Feb 22.

Howard Hughes Medical Institute, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.

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http://dx.doi.org/10.1016/j.cell.2007.02.013DOI Listing
March 2007

Recent insights into the molecular pathogenesis of pheochromocytoma and paraganglioma.

Endocr Pathol 2006 ;17(2):97-106

Department of Urology, Graduate School of Medicine, Kyoto University.

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http://dx.doi.org/10.1385/ep:17:2:97DOI Listing
February 2007

Retinoblastoma protein and anaphase-promoting complex physically interact and functionally cooperate during cell-cycle exit.

Nat Cell Biol 2007 Feb 24;9(2):225-32. Epub 2006 Dec 24.

Massachusetts General Hospital Cancer Center and Harvard Medical School, Charlestown, Massachusetts, MA 02129, USA.

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http://www.nature.com/articles/ncb1532
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February 2007

The von Hippel-Lindau tumor suppressor protein and clear cell renal carcinoma.

Authors:
William G Kaelin

Clin Cancer Res 2007 Jan;13(2 Pt 2):680s-684s

Howard Hughes Medical Institute, Dana-Farber Cancer Institute and Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1158/1078-0432.CCR-06-1865DOI Listing
January 2007

Failure to prolyl hydroxylate hypoxia-inducible factor alpha phenocopies VHL inactivation in vivo.

EMBO J 2006 Oct 14;25(19):4650-62. Epub 2006 Sep 14.

Department of Medical Oncology, Dana-Farber Cancer Institute and Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1038/sj.emboj.7601300DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1589988PMC
October 2006

Molecular pathways in renal cell carcinoma--rationale for targeted treatment.

Semin Oncol 2006 Oct;33(5):588-95

Department of Hematology Oncology, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

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http://dx.doi.org/10.1053/j.seminoncol.2006.06.001DOI Listing
October 2006

Cell biology: divining cancer cell weaknesses.

Authors:
William G Kaelin

Nature 2006 May;441(7089):32-4

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May 2006

Mouse model for noninvasive imaging of HIF prolyl hydroxylase activity: assessment of an oral agent that stimulates erythropoietin production.

Proc Natl Acad Sci U S A 2006 Jan 22;103(1):105-10. Epub 2005 Dec 22.

Department of Medical Oncology, Dana-Farber Cancer Institute, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.

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http://www.pnas.org/cgi/doi/10.1073/pnas.0509459103
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1324998PMC
January 2006

The von Hippel-Lindau protein, HIF hydroxylation, and oxygen sensing.

Authors:
William G Kaelin

Biochem Biophys Res Commun 2005 Dec 30;338(1):627-38. Epub 2005 Aug 30.

Howard Hughes Medical Institute, Dana-Farber Cancer Institute and Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.

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December 2005