William E Rainey

William E Rainey

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William E Rainey

William E Rainey

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11-Oxygenated C19 Steroids Do Not Decline With Age in Women.

J Clin Endocrinol Metab 2019 Jul;104(7):2615-2622

Division of Metabolism, Endocrinology, and Diabetes, University of Michigan, Ann Arbor, Michigan.

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http://dx.doi.org/10.1210/jc.2018-02527DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6525564PMC
July 2019

Steroid biomarkers in human adrenal disease.

J Steroid Biochem Mol Biol 2019 Jun 29;190:273-280. Epub 2019 Jan 29.

Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI 48109, United States; Division of Metabolism, Endocrinology, and Diabetes, Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, United States. Electronic address:

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http://dx.doi.org/10.1016/j.jsbmb.2019.01.018DOI Listing
June 2019

Circulating 11-oxygenated androgens across species.

J Steroid Biochem Mol Biol 2019 Jun 5;190:242-249. Epub 2019 Apr 5.

Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI, United States; Division of Metabolism, Endocrinology, and Diabetes, Department of Internal Medicine, University of Michigan, Ann Arbor, MI, United States. Electronic address:

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http://dx.doi.org/10.1016/j.jsbmb.2019.04.005DOI Listing
June 2019

Adrenal Vein Sampling Lateralization Despite Mineralocorticoid Receptor Antagonists Exposure in Primary Aldosteronism.

J Clin Endocrinol Metab 2019 Feb;104(2):487-492

Division of Metabolism, Endocrinology, and Diabetes, University of Michigan, Ann Arbor, Michigan.

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http://dx.doi.org/10.1210/jc.2018-01299DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6316984PMC
February 2019

Targeted Molecular Characterization of Aldosterone-Producing Adenomas in White Americans.

J Clin Endocrinol Metab 2018 10;103(10):3869-3876

Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, Michigan.

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http://dx.doi.org/10.1210/jc.2018-01004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6179168PMC
October 2018

Human Urinary mRNA as a Biomarker of Cardiovascular Disease.

Circ Genom Precis Med 2018 09;11(9):e002213

Departments of Internal Medicine, University of Michigan, Ann Arbor (B.G.B., R.J.A., S.L.H., J.B.B.).

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https://www.ahajournals.org/doi/10.1161/CIRCGEN.118.002213
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http://dx.doi.org/10.1161/CIRCGEN.118.002213DOI Listing
September 2018

High-Resolution Tissue Mass Spectrometry Imaging Reveals a Refined Functional Anatomy of the Human Adult Adrenal Gland.

Endocrinology 2018 03;159(3):1511-1524

Department of Internal Medicine, Division of Endocrinology and Diabetology, University Hospital Würzburg, University of Würzburg, Würzburg, Germany.

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http://dx.doi.org/10.1210/en.2018-00064DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5839739PMC
March 2018

Aging and Adrenal Aldosterone Production.

Hypertension 2018 02 11;71(2):218-223. Epub 2017 Dec 11.

From the Department of Molecular and Integrative Physiology (K.N., W.E.R.), and Department of Internal Medicine (W.E.R.), University of Michigan, Ann Arbor; and Center for Adrenal Disorders, Division of Endocrinology, Diabetes, and Hypertension, Brigham and Women's Hospital and Harvard Medical School, Boston, MA (A.V.).

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http://dx.doi.org/10.1161/HYPERTENSIONAHA.117.10391DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5839673PMC
February 2018

Adrenocorticotropin Acutely Regulates Pregnenolone Sulfate Production by the Human Adrenal In Vivo and In Vitro.

J Clin Endocrinol Metab 2018 01;103(1):320-327

Division of Metabolism, Endocrinology, and Diabetes, University of Michigan, Ann Arbor, Michigan.

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http://dx.doi.org/10.1210/jc.2017-01525DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5761485PMC
January 2018

Discordance between imaging and immunohistochemistry in unilateral primary aldosteronism.

Clin Endocrinol (Oxf) 2017 Dec 4;87(6):665-672. Epub 2017 Sep 4.

Division of Metabolism, Endocrinology, and Diabetes, University of Michigan, Ann Arbor, MI, USA.

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http://dx.doi.org/10.1111/cen.13442DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5698145PMC
December 2017

Aldosterone-Producing Cell Clusters in Normal and Pathological States.

Horm Metab Res 2017 Dec 4;49(12):951-956. Epub 2017 Dec 4.

Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI, USA.

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http://dx.doi.org/10.1055/s-0043-122394DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5770278PMC
December 2017

GPER-independent inhibition of adrenocortical cancer growth by G-1 involves ROS/Egr-1/BAX pathway.

Oncotarget 2017 Dec 14;8(70):115609-115619. Epub 2017 Dec 14.

Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, Arcavacata di Rende, Cosenza, Italy.

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http://dx.doi.org/10.18632/oncotarget.23314DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5777797PMC
December 2017

Development of monoclonal antibodies against the human 3β-hydroxysteroid dehydrogenase/isomerase isozymes.

Steroids 2017 11 31;127:56-61. Epub 2017 Aug 31.

Department of Pharmacology and Toxicology, University of Mississippi Medical Center, Jackson, MS, USA.

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http://dx.doi.org/10.1016/j.steroids.2017.08.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5628156PMC
November 2017

Age-Related Autonomous Aldosteronism.

Circulation 2017 Jul 31;136(4):347-355. Epub 2017 May 31.

From Departments of Molecular and Integrative Physiology & Internal Medicine, University of Michigan, Ann Arbor (K.N., I.Z., W.E.R.); Center for Adrenal Disorders, Division of Endocrinology, Diabetes, and Hypertension, Brigham and Women's Hospital and Harvard Medical School, Boston, MA (A.V., G.H.W.); and Division of Metabolism, Endocrinology, and Diabetes, University of Michigan, Ann Arbor (T.E., W.E.R.).

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http://dx.doi.org/10.1161/CIRCULATIONAHA.117.028201DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5568806PMC
July 2017

Genetic and Histopathologic Intertumor Heterogeneity in Primary Aldosteronism.

J Clin Endocrinol Metab 2017 06;102(6):1792-1796

Center for Adrenal Disorders, Division of Endocrinology, Diabetes and Hypertension, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115.

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http://dx.doi.org/10.1210/jc.2016-4007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5470766PMC
June 2017

Very low-density lipoprotein (VLDL)-induced signals mediating aldosterone production.

J Endocrinol 2017 02 2;232(2):R115-R129. Epub 2016 Dec 2.

Department of PhysiologyMedical College of Georgia at Augusta University (formerly Georgia Regents University), Augusta, Georgia, USA

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http://dx.doi.org/10.1530/JOE-16-0237DOI Listing
February 2017

Age-dependent Increases in Adrenal Cytochrome b5 and Serum 5-Androstenediol-3-sulfate.

J Clin Endocrinol Metab 2016 12 13;101(12):4585-4593. Epub 2016 Sep 13.

Department of Molecular and Integrative Physiology (J.R., S.K., W.E.R.), University of Michigan, Ann Arbor, Michigan 48109; Department of Internal Medicine (A.M.L., R.J.A.), University of Michigan, Ann Arbor, Michigan 48109; Division of Pediatric Endocrinology (J.M.S.), Specially for Children, Austin, Texas 78723; Department of Pediatrics (J.Z.K.-V.), University of Michigan, Ann Arbor, Michigan 48109; Department of Pathology (H.S., Y.N.), Tohoku University School of Medicine, Sendai, 980-8575 Japan; Division of Pathology, Faculty of Medicine (Y.N.), Tohoku Medical and Pharmaceutical University, Sendai, Miyagi 981-8558, Japan; and Department of Pediatrics (P.C.W.), University of Texas Southwestern Medical Center, Dallas, Texas 75235.

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http://dx.doi.org/10.1210/jc.2016-2864DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5155691PMC
December 2016

VLDL-activated cell signaling pathways that stimulate adrenal cell aldosterone production.

Mol Cell Endocrinol 2016 09 21;433:138-46. Epub 2016 May 21.

Charlie Norwood VA Medical Center, One Freedom Way, Augusta, GA, 30904, United States; Department of Physiology, Medical College of Georgia at Augusta University, 1120 15th Street, Augusta, GA, 30912, United States. Electronic address:

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http://dx.doi.org/10.1016/j.mce.2016.05.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4955520PMC
September 2016

Synthetic High-Density Lipoprotein (sHDL) Inhibits Steroid Production in HAC15 Adrenal Cells.

Endocrinology 2016 08 2;157(8):3122-9. Epub 2016 Jun 2.

Departments of Molecular and Integrative Physiology and Internal Medicine (M.J.T., A.R.S., K.A.,W.E.R.)., University of Michigan, Ann Arbor, Michigan 48109; Medical College of Georgia (A.R.S.), Georgia Regents University, Augusta, Georgia 30912; Department of Pharmaceutical Science (E.E.M., A.S.), Biointerfaces Institute, University of Michigan, Ann Arbor, Michigan 48109; and Department of Medicinal Chemistry (E.R.-F.), College of Pharmacy, University of Michigan, Ann Arbor, Michigan 48109.

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http://dx.doi.org/10.1210/en.2014-1663DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4967112PMC
August 2016

Mutated KCNJ5 activates the acute and chronic regulatory steps in aldosterone production.

J Mol Endocrinol 2016 07 20;57(1):1-11. Epub 2016 Apr 20.

Department of Internal MedicineDivision of Metabolism, Endocrinology and Diabetes, University of Michigan, Ann Arbor, Michigan, USA

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http://dx.doi.org/10.1530/JME-15-0324DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5027885PMC
July 2016

Adrenal-derived 11-oxygenated 19-carbon steroids are the dominant androgens in classic 21-hydroxylase deficiency.

Eur J Endocrinol 2016 May 10;174(5):601-9. Epub 2016 Feb 10.

Division of MetabolismEndocrinology and Diabetes, University of Michigan, 1150 W Medical Center Drive, Ann Arbor, Michigan, 48109, USA Department of PharmacologyUniversity of Michigan, Ann Arbor, Michigan, USA

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http://www.eje-online.org/content/early/2016/02/09/EJE-15-11
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http://www.eje-online.org/lookup/doi/10.1530/EJE-15-1181
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http://dx.doi.org/10.1530/EJE-15-1181DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4874183PMC
May 2016

ATR-101, a Selective and Potent Inhibitor of Acyl-CoA Acyltransferase 1, Induces Apoptosis in H295R Adrenocortical Cells and in the Adrenal Cortex of Dogs.

Endocrinology 2016 05 17;157(5):1775-88. Epub 2016 Mar 17.

Departments of Internal Medicine (C.R.L., G.D.H.), Pathology (J.E.M.), and Molecular and Integrative Physiology (W.E.R., V.C.), University of Michigan, Ann Arbor, Michigan 48109; and Atterocor, Inc (S.W.H.), Ann Arbor, Michigan 48104.

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http://dx.doi.org/10.1210/en.2015-2052DOI Listing
May 2016

Molecular Heterogeneity in Aldosterone-Producing Adenomas.

J Clin Endocrinol Metab 2016 Mar 14;101(3):999-1007. Epub 2016 Jan 14.

Departments of Molecular and Integrative Physiology and Internal Medicine (K.N., A.X.C., G.D.H., W.E.R.), Pathology (K.O., M.V., T.J.G., S.A.T.), and Urology (S.A.T.), Comprehensive Cancer Center (T.J.G., T.E., S.A.T.), Division of Metabolism, Endocrinology, and Diabetes (T.J.G., T.E., G.D.H.), Endocrine Oncology Program (T.E., G.D.H.), Center for Organogenesis, and Michigan Center for Translational Pathology (S.A.T.), University of Michigan, Ann Arbor, Michigan 48109.

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http://dx.doi.org/10.1210/jc.2015-3239DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4803171PMC
March 2016

H295R expression of melanocortin 2 receptor accessory protein results in ACTH responsiveness.

J Mol Endocrinol 2016 Feb 17;56(2):69-76. Epub 2015 Nov 17.

Departments of Molecular & Integrative Physiology and Internal MedicineUniversity of Michigan, 1150 West Medical Center Drive, Ann Arbor, Michigan 48109, USADivision of MetabolismEndocrinology, and Diabetes, University of Michigan, 1150 West Medical Center Drive, Ann Arbor, Michigan 48109, USA Departments of Molecular & Integrative Physiology and Internal MedicineUniversity of Michigan, 1150 West Medical Center Drive, Ann Arbor, Michigan 48109, USADivision of MetabolismEndocrinology, and Diabetes, University of Michigan, 1150 West Medical Center Drive, Ann Arbor, Michigan 48109, USA

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https://jme.bioscientifica.com/view/journals/jme/56/2/69.xml
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http://dx.doi.org/10.1530/JME-15-0230DOI Listing
February 2016

Development of a novel cell based androgen screening model.

J Steroid Biochem Mol Biol 2016 Feb 12;156:17-22. Epub 2015 Nov 12.

Departments of Molecular & Integrative Physiology and Internal Medicine, University of Michigan, Medical School, Ann Arbor, MI, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jsbmb.2015.11.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4748855PMC
February 2016

Potassium channels related to primary aldosteronism: Expression similarities and differences between human and rat adrenals.

Mol Cell Endocrinol 2015 Dec 12;417:141-8. Epub 2015 Sep 12.

Department of Molecular and Integrative Physiology, University of Michigan, 1150 W. Medical Center Dr, Ann Arbor, MI 48109, USA; Department of Internal Medicine, University of Michigan, 1150 W. Medical Center Dr, Ann Arbor, MI 48109, USA. Electronic address:

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http://dx.doi.org/10.1016/j.mce.2015.09.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4646165PMC
December 2015

Exploiting the Unusual to Find the Rare: Novel Steroid Metabolites Pinpoint Adrenal Cancer Patients.

Horm Cancer 2015 Aug 12;6(4):129-30. Epub 2015 Jun 12.

Division of Metabolism, Endocrinology and Diabetes (MEND), Department of Internal Medicine, University of Michigan Health System, 2560E MSRB2, 1150 West Medical Center Drive, Ann Arbor, MI, 48109-5674, USA,

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http://dx.doi.org/10.1007/s12672-015-0229-yDOI Listing
August 2015

Aldosterone-stimulating somatic gene mutations are common in normal adrenal glands.

Proc Natl Acad Sci U S A 2015 Aug 3;112(33):E4591-9. Epub 2015 Aug 3.

Departments of Molecular and Integrative Physiology and Internal Medicine, University of Michigan, Ann Arbor, MI 48109;

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http://dx.doi.org/10.1073/pnas.1505529112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4547250PMC
August 2015

Bone Morphogenetic Protein-4 (BMP4): A Paracrine Regulator of Human Adrenal C19 Steroid Synthesis.

Endocrinology 2015 Jul 13;156(7):2530-40. Epub 2015 Apr 13.

Department of Molecular and Integrative Physiology (J.R., H.K.N., K.N., W.E.R.), and Division of Metabolism, Endocrinology, and Diabetes, Department of Internal Medicine, University of Michigan (R.J.A.), Ann Arbor, Michigan 48109-5622; and School of Pediatrics and Reproductive Health (R.J.R.), Robinson Research Institute, University of Adelaide, South Australia 5005, Australia.

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http://dx.doi.org/10.1210/en.2014-1942DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4475723PMC
July 2015

Introduction to the 2014 Adrenal Cortex Conference Keith L. Parker Memorial Lecturer: Bernard Schimmer, Ph.D.

Authors:
William E Rainey

Mol Cell Endocrinol 2015 Jun 24;408:2-4. Epub 2014 Dec 24.

Departments of Molecular and Integrative Physiology and Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA. Electronic address:

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http://dx.doi.org/10.1016/j.mce.2014.12.018DOI Listing
June 2015

Profiles of 21-Carbon Steroids in 21-hydroxylase Deficiency.

J Clin Endocrinol Metab 2015 Jun 7;100(6):2283-90. Epub 2015 Apr 7.

Division of Metabolism, Endocrinology, and Diabetes (A.F.T., J.L., T.E., A.G.M., W.E.R., R.J.A.), Department of Molecular and Integrative Physiology and Medicine (J.R., H.K.N., W.E.R.), Michigan Metabolomics and Obesity Center (R.C.), Department of Urology (G.S.P.), and Department of Pharmacology (R.J.A.), University of Michigan, Ann Arbor, Michigan 48109.

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https://academic.oup.com/jcem/article-lookup/doi/10.1210/jc.
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http://dx.doi.org/10.1210/jc.2015-1023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4454804PMC
June 2015

Expression and functional role of the prorenin receptor in the human adrenocortical zona glomerulosa and in primary aldosteronism.

J Hypertens 2015 May;33(5):1014-22

aDepartment of Medicine - DIMED, Padova, Italy bCARIM - School for Cardiovascular Diseases, Maastricht University, Maastricht, The Netherlands cDepartment of Molecular Medicine, University of Padova, Padova, Italy dMolecular & Integrative Physiology, Ann Arbor, University of Michigan, Ann Arbor, Michigan, USA eDepartment of Internal Medicine - Division of Angiology and Hypertension, University of Lausanne, Switzerland. *Chiara Recarti and Teresa Maria Seccia contributed equally to the writing of this article.

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http://content.wkhealth.com/linkback/openurl?sid=WKPTLP:land
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http://dx.doi.org/10.1097/HJH.0000000000000504DOI Listing
May 2015

Role of Ca(2+)/calmodulin-dependent protein kinase kinase in adrenal aldosterone production.

Endocrinology 2015 May 13;156(5):1750-6. Epub 2015 Feb 13.

Department of Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, Michigan 48109.

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http://dx.doi.org/10.1210/en.2014-1782DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4398758PMC
May 2015

Measurement of peripheral plasma 18-oxocortisol can discriminate unilateral adenoma from bilateral diseases in patients with primary aldosteronism.

Hypertension 2015 May 16;65(5):1096-102. Epub 2015 Mar 16.

From the Division of Nephrology, Endocrinology, and Vascular Medicine, Departments of Medicine (F.S., R.M., Y.O., Y.I., K.O., M.K., S.I.), Radiology (K.T., K.S.), Urology (Y.A.), and Pathology (H.S., Y.N.), Tohoku University Hospital, Sendai, Japan; Aska Pharma Medical Co Ltd, Kawasaki, Japan (H.S., S.H., M.O.); Division of Faculty of Pharmaceutical Science, Tohoku Pharmaceutical University, Sendai, Japan (K.Y.); Division of Endocrinology, University of Mississippi Medical Center, Jackson (C.E.G.-S.); and Molecular and Integrative Physiology, University of Michigan, Ann Arbor (W.E.R.).

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http://dx.doi.org/10.1161/HYPERTENSIONAHA.114.04453DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4642692PMC
May 2015

Cell-based assays for screening androgen receptor ligands.

Semin Reprod Med 2015 May 2;33(3):225-34. Epub 2015 Jun 2.

Departments of Molecular and Integrative Physiology and Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan.

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https://www.thieme-connect.com/products/ejournals/pdf/10.105
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http://www.thieme-connect.de/DOI/DOI?10.1055/s-0035-1552989
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http://dx.doi.org/10.1055/s-0035-1552989DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4624207PMC
May 2015

Understanding primary aldosteronism: impact of next generation sequencing and expression profiling.

Mol Cell Endocrinol 2015 Jan 18;399:311-20. Epub 2014 Sep 18.

Department of Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, MI, USA.

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http://dx.doi.org/10.1016/j.mce.2014.09.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4285708PMC
January 2015

Adrenal androgens and androgen precursors-definition, synthesis, regulation and physiologic actions.

Compr Physiol 2014 Oct;4(4):1369-81

Department of Internal Medicine, Division of Metabolism Endocrinology and Diabetes, University of Michigan, Ann Arbor, Michigan; Department of Pediatrics, Division of Pediatric Endocrinology, University of Texas Southwestern Medical Center, Texas; Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, Michigan.

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http://dx.doi.org/10.1002/cphy.c140006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4437668PMC
October 2014

Metallothionein-3 (MT-3) in the human adrenal cortex and its disorders.

Endocr Pathol 2014 Sep;25(3):229-35

Department of Pathology, Tohoku University Graduate School of Medicine, 2-1 Seiryo-machi, Aoba-ku, Sendai, Miyagi, 980-8575, Japan.

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http://link.springer.com/content/pdf/10.1007/s12022-013-9280
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http://link.springer.com/10.1007/s12022-013-9280-9
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http://dx.doi.org/10.1007/s12022-013-9280-9DOI Listing
September 2014

Phospholipase D activity underlies very-low-density lipoprotein (VLDL)-induced aldosterone production in adrenal glomerulosa cells.

Endocrinology 2014 Sep 23;155(9):3550-60. Epub 2014 Jun 23.

Charlie Norwood VA Medical Center (V.C., W.B.B.), Augusta, Georgia 30904; Department of Physiology (Y.-Y.T., W.E.R., Z.P., V.C., W.B.B.), Medical College of Georgia at Georgia Regents University, Augusta, Georgia 30912; and Department of Pharmacology and Center for Developmental Genetics (M.A.F.), Stony Brook University, Stony Brook, New York 11794.

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http://dx.doi.org/10.1210/en.2014-1159DOI Listing
September 2014

Lower expression of the TWIK-related acid-sensitive K+ channel 2 (TASK-2) gene is a hallmark of aldosterone-producing adenoma causing human primary aldosteronism.

J Clin Endocrinol Metab 2014 Apr 27;99(4):E674-82. Epub 2013 Nov 27.

Internal Medicine 4 (L.L., B.C., A.G.C., T.M.S., M.K., S.F., G.S., G.P.R.) and Surgical Pathology and Cytopathology Unit (A.F.), Department of Medicine, Department of Medicine, Section of Human Anatomy and Physiology (A.S.B.), Department of Molecular Medicine, University of Padua, 35128 Padua, Italy; Max-Delbrück-Center for Molecular Medicine (M.B.), 13092 Berlin, Germany; and Department of Molecular and Integrative Physiology (W.E.R.), University of Michigan, Ann Arbor, Michigan 48109.

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http://dx.doi.org/10.1210/jc.2013-2900DOI Listing
April 2014

PCP4: a regulator of aldosterone synthesis in human adrenocortical tissues.

J Mol Endocrinol 2014 Apr 24;52(2):159-67. Epub 2014 Feb 24.

Department of Pathology, Tohoku University Graduate School of Medicine, 2-1 Seiryo-machi, Aoba-ku, Sendai, Miyagi 980-8575, Japan Division of Nephrology, Endocrinology and Vascular Medicine, Tohoku University Hospital, Sendai, Japan Departments of Diagnostic Radiology Molecular Endocrinology, Tohoku University Graduate School of Medicine, 2-1 Seiryo-machi, Aoba-ku, Sendai, Miyagi 980-8575, Japan Department of Physiology and Medicine, University of Michigan, Ann Arbor, Michigan, USA.

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http://dx.doi.org/10.1530/JME-13-0248DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4103644PMC
April 2014

Sodium deficiency regulates rat adrenal zona glomerulosa gene expression.

Endocrinology 2014 Apr 14;155(4):1363-72. Epub 2014 Jan 14.

Department of Molecular and Integrative Physiology (K.N., W.E.R.), University of Michigan, Ann Arbor, Michigan 48109; Department of Physiology (R.B.S.H., T.S.), Georgia Regents University, Augusta, Georgia 30912; and Department of Urology (K.N.), Tachikawa Hospital, Tachikawa, 190-0022 Tokyo, Japan.

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http://dx.doi.org/10.1210/en.2013-1999DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3959598PMC
April 2014

Angiotensin II receptor blockers differentially affect CYP11B2 expression in human adrenal H295R cells.

Mol Cell Endocrinol 2014 Mar 12;383(1-2):60-8. Epub 2013 Dec 12.

Department of Molecular Endocrinology, Tohoku University Graduate School of Medicine, Sendai 980-8575, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.mce.2013.12.004DOI Listing
March 2014

Transcriptome profiling reveals differentially expressed transcripts between the human adrenal zona fasciculata and zona reticularis.

J Clin Endocrinol Metab 2014 Mar 1;99(3):E518-27. Epub 2013 Jan 1.

Departments of Molecular and Integrative Physiology and Internal Medicine (J.R., W.E.R.), University of Michigan Medical School, Ann Arbor, Michigan 48109; Departments of Physiology (J.R., T.W., W.E.R.) and Surgery (T.D.M.), Georgia Regents University, Augusta, Georgia 30912; and Department of Pathology (Y.N., H.S.), Tohoku University School of Medicine, Sendai 980-8579, Japan.

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http://dx.doi.org/10.1210/jc.2013-3198DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3942232PMC
March 2014

Gene mutations that promote adrenal aldosterone production, sodium retention, and hypertension.

Appl Clin Genet 2013 Dec 24;7:1-13. Epub 2013 Dec 24.

Division of Metabolism, Endocrinology, and Diabetes, Department of Internal Medicine, Ann Arbor, MI, USA.

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http://dx.doi.org/10.2147/TACG.S35571DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3882136PMC
December 2013

11β-hydroxyandrostenedione, the product of androstenedione metabolism in the adrenal, is metabolized in LNCaP cells by 5α-reductase yielding 11β-hydroxy-5α-androstanedione.

J Steroid Biochem Mol Biol 2013 Nov 16;138:132-42. Epub 2013 May 16.

Department of Biochemistry, University of Stellenbosch, Stellenbosch 7600, South Africa. Electronic address:

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http://dx.doi.org/10.1016/j.jsbmb.2013.04.010DOI Listing
November 2013

a Novel Y152C KCNJ5 mutation responsible for familial hyperaldosteronism type III.

J Clin Endocrinol Metab 2013 Nov 13;98(11):E1861-5. Epub 2013 Sep 13.

Department of Medical Sciences, Medicina Interna 4, University of Torino, Via Genova 3, 10126 Torino, Italy.

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http://dx.doi.org/10.1210/jc.2013-2428DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3816265PMC
November 2013

Lessons from the gene expression pattern of the rat zona glomerulosa.

Mol Cell Endocrinol 2013 May 31;371(1-2):107-13. Epub 2012 Dec 31.

Department of Physiology, Medical College of Georgia, Georgia Health Sciences University, Augusta, GA 30912, USA. Department of Urology, Tachikawa Hospital, Tokyo 190-8531, Japan.

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http://dx.doi.org/10.1016/j.mce.2012.12.023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3625490PMC
May 2013

Role of KCNJ5 in familial and sporadic primary aldosteronism.

Nat Rev Endocrinol 2013 Feb 11;9(2):104-12. Epub 2012 Dec 11.

University of Torino, Department of Medical Sciences, Division of Internal Medicine and Hypertension, Italy. paolo.mulatero@ unito.it

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http://dx.doi.org/10.1038/nrendo.2012.230DOI Listing
February 2013

Adrenal disorders in pregnancy.

Nat Rev Endocrinol 2012 Nov 11;8(11):668-78. Epub 2012 Sep 11.

Department of Physiology, Georgia Health Sciences University, 1120 15th Street, Augusta, GA 30912, USA.

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http://dx.doi.org/10.1038/nrendo.2012.155DOI Listing
November 2012

The steroid metabolome of adrenarche.

J Endocrinol 2012 Aug 19;214(2):133-43. Epub 2012 Jun 19.

Department of Physiology, Georgia Health Sciences University, Augusta, Georgia 30912, USA.

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http://dx.doi.org/10.1530/JOE-12-0183DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4041616PMC
August 2012

The development of hypertension and hyperaldosteronism in a rodent model of life-long obesity.

Endocrinology 2012 Apr 21;153(4):1764-73. Epub 2012 Feb 21.

Department of Pharmacology and Toxicology, Michigan State University, East Lansing, Michigan 48824, USA.

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http://dx.doi.org/10.1210/en.2011-1176DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3320259PMC
April 2012

Transcriptome analysis reveals differentially expressed transcripts in rat adrenal zona glomerulosa and zona fasciculata.

Endocrinology 2012 Apr 28;153(4):1755-63. Epub 2012 Feb 28.

Department of Physiology, Georgia Health Sciences University, Augusta, Georgia 30912, USA.

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http://dx.doi.org/10.1210/en.2011-1915DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3320243PMC
April 2012

Acute and chronic regulation of aldosterone production.

Mol Cell Endocrinol 2012 Mar 4;350(2):151-62. Epub 2011 Aug 4.

Department of Physiology, Georgia Health Sciences University (formerly Medical College of Georgia), 1120 15th Street, Augusta, GA 30912, USA.

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http://dx.doi.org/10.1016/j.mce.2011.07.034DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3253327PMC
March 2012

Human adrenocortical carcinoma cell lines.

Mol Cell Endocrinol 2012 Mar 5;351(1):58-65. Epub 2011 Sep 5.

Department of Physiology, Georgia Health Sciences University, Augusta, GA 30912, USA.

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http://dx.doi.org/10.1016/j.mce.2011.08.041DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3288152PMC
March 2012

Adrenal cell aldosterone production is stimulated by very-low-density lipoprotein (VLDL).

Endocrinology 2012 Feb 20;153(2):721-31. Epub 2011 Dec 20.

Department of Physiology, Georgia Health Sciences University, 1120 15th Street, Augusta, Georgia 30912, USA.

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http://dx.doi.org/10.1210/en.2011-1752DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3275386PMC
February 2012

Differential gene expression in the adrenals of normal and anencephalic fetuses and studies focused on the Fras-1-related extracellular matrix protein (FREM2) gene.

Reprod Sci 2011 Nov;18(11):1146-53

Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology and Infertility, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390, USA.

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http://dx.doi.org/10.1177/1933719111408113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3343145PMC
November 2011

18-oxocortisol measurement in adrenal vein sampling as a biomarker for subclassifying primary aldosteronism.

J Clin Endocrinol Metab 2011 Aug 18;96(8):E1272-8. Epub 2011 May 18.

Division of Nephrology, Endocrinology, and Vascular Medicine, Department of Medicine, Tohoku University Graduate School of Medicine, Aoba-ku, Sendai 980-8574, Japan.

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http://dx.doi.org/10.1210/jc.2010-2785DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5393430PMC
August 2011

Impact of leptin-mediated sympatho-activation on cardiovascular function in obese mice.

Hypertension 2011 Aug 20;58(2):271-9. Epub 2011 Jun 20.

Georgia Health Sciences University, Vascular Biology Center, 1459 Laney Walker Blvd, Augusta, GA 30912, USA.

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http://dx.doi.org/10.1161/HYPERTENSIONAHA.110.168427DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3141100PMC
August 2011

Linkage of regulators of TGF-β activity in the fetal ovary to polycystic ovary syndrome.

FASEB J 2011 Jul 16;25(7):2256-65. Epub 2011 Mar 16.

Research Centre for Reproductive Health, Discipline of Obstetrics and Gynaecology, Robinson Institute, University of Adelaide, SA, 5005, Australia.

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http://dx.doi.org/10.1096/fj.11-181099DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3219214PMC
July 2011

The effects of ACTH on steroid metabolomic profiles in human adrenal cells.

J Endocrinol 2011 Jun 23;209(3):327-35. Epub 2011 Mar 23.

Department of Physiology and Surgery, Georgia Health University, Augusta, Georgia 30912, USA.

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http://dx.doi.org/10.1530/JOE-10-0493DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3774117PMC
June 2011

Coactivation of SF-1-mediated transcription of steroidogenic enzymes by Ubc9 and PIAS1.

Endocrinology 2011 Jun 5;152(6):2266-77. Epub 2011 Apr 5.

Department of Internal Medicine, School of Medicine, Keio University, Shinjujku-ku, Tokyo 160-8582, Japan.

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http://dx.doi.org/10.1210/en.2010-1232DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3100613PMC
June 2011

Gene expression profiles in aldosterone-producing adenomas and adjacent adrenal glands.

Eur J Endocrinol 2011 Apr 19;164(4):613-9. Epub 2011 Jan 19.

Department of Physiology, Medical College of Georgia, 1120 15th Street, Augusta, Georgia 30912, USA.

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http://dx.doi.org/10.1530/EJE-10-1085DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3741645PMC
April 2011

Clinical, biochemical, and molecular characterization of macronodular adrenocortical hyperplasia of the zona reticularis: a new syndrome.

J Clin Endocrinol Metab 2011 Feb 17;96(2):E243-50. Epub 2010 Nov 17.

Division of Endocrinology and Metabolism, Department of Internal Medicine, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390-8857, USA.

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https://academic.oup.com/jcem/article-lookup/doi/10.1210/jc.
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http://dx.doi.org/10.1210/jc.2010-1222DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3048321PMC
February 2011

Peroxisome proliferator-activated receptor-{gamma} suppresses CYP11B2 expression and aldosterone production.

J Mol Endocrinol 2011 Feb 19;46(1):37-49. Epub 2011 Jan 19.

Department of Advanced Biological Sciences for Regeneration, Tohoku University Graduate School of Medicine, 2-1 Seiryo-machi, Aoba-ku, Sendai 980-8575, Japan.

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http://dx.doi.org/10.1677/JME-10-0088DOI Listing
February 2011

Human adrenal cells that express both 3β-hydroxysteroid dehydrogenase type 2 (HSD3B2) and cytochrome b5 (CYB5A) contribute to adrenal androstenedione production.

J Steroid Biochem Mol Biol 2011 Feb 23;123(3-5):122-6. Epub 2010 Dec 23.

Department of Pathology, Tohoku University School of Medicine, 2-1 Seiryo-machi, Aoba-ku, Sendai 980-8575, Japan.

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http://dx.doi.org/10.1016/j.jsbmb.2010.12.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4269365PMC
February 2011

The AP-1 family member FOS blocks transcriptional activity of the nuclear receptor steroidogenic factor 1.

J Cell Sci 2010 Nov 27;123(Pt 22):3956-65. Epub 2010 Oct 27.

Department of Pharmaco-Biology and Cell Biology, University of Calabria, Arcavacata di Rende (CS) 87036, Italy.

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http://dx.doi.org/10.1242/jcs.055806DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2972275PMC
November 2010

The role of TASK1 in aldosterone production and its expression in normal adrenal and aldosterone-producing adenomas.

Clin Endocrinol (Oxf) 2010 Jul 28;73(1):22-9. Epub 2009 Oct 28.

Department of Physiology, Medical College of Georgia, Augusta, GA 30912, USA.

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http://dx.doi.org/10.1111/j.1365-2265.2009.03738.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4158746PMC
July 2010

ACTH is a potent regulator of gene expression in human adrenal cells.

J Mol Endocrinol 2010 Jul 11;45(1):59-68. Epub 2010 May 11.

Departments of Physiology and Surgery, Medical College of Georgia, Augusta, Georgia 30912, USA.

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http://dx.doi.org/10.1677/JME-10-0006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3725639PMC
July 2010

Regulation of aldosterone synthase by activator transcription factor/cAMP response element-binding protein family members.

Endocrinology 2010 Mar 22;151(3):1060-70. Epub 2010 Jan 22.

Department of Physiology, Medical College of Georgia, 1120 15th Street, Augusta, Georgia 30912, USA.

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http://dx.doi.org/10.1210/en.2009-0977DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2840695PMC
March 2010

Genetic and gene expression analyses of the polycystic ovary syndrome candidate gene fibrillin-3 and other fibrillin family members in human ovaries.

Mol Hum Reprod 2009 Dec 19;15(12):829-41. Epub 2009 Aug 19.

Research Centre for Reproductive Health, Robinson Institute and School of Paediatrics and Reproductive Health, University of Adelaide, Adelaide, SA 5005, Australia.

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http://dx.doi.org/10.1093/molehr/gap072DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2776474PMC
December 2009

Development of the human adrenal zona reticularis: morphometric and immunohistochemical studies from birth to adolescence.

J Endocrinol 2009 Nov 1;203(2):241-52. Epub 2009 Sep 1.

Department of Pathology, Tohoku University School of Medicine, 2-1 Seiryo-machi, Aoba-ku, Sendai 980-8575, Japan.

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http://dx.doi.org/10.1677/JOE-09-0127DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4159054PMC
November 2009

The mediator complex subunit 1 enhances transcription of genes needed for adrenal androgen production.

Endocrinology 2009 Sep 4;150(9):4145-53. Epub 2009 Jun 4.

Department of Physiology, University of Veterinary Medicine, 30173 Hannover, Germany.

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http://dx.doi.org/10.1210/en.2009-0006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2736083PMC
September 2009

Role of angiotensin II-induced rapid response genes in the regulation of enzymes needed for aldosterone synthesis.

J Mol Endocrinol 2009 Apr 21;42(4):319-30. Epub 2009 Jan 21.

Department of Physiology, Medical College of Georgia, Augusta, Georgia 30912, USA.

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http://dx.doi.org/10.1677/JME-08-0112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4176876PMC
April 2009

G protein-coupled receptor expression in the adult and fetal adrenal glands.

Mol Cell Endocrinol 2009 Mar 5;300(1-2):43-50. Epub 2008 Nov 5.

Department of Physiology, Medical College of Georgia, Augusta, GA 30912, United States.

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http://dx.doi.org/10.1016/j.mce.2008.10.036DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2679220PMC
March 2009

The farnesoid X receptor regulates transcription of 3beta-hydroxysteroid dehydrogenase type 2 in human adrenal cells.

Mol Cell Endocrinol 2009 Feb 18;299(2):153-62. Epub 2008 Nov 18.

Department of Physiology, Medical College of Georgia, Augusta, GA 30912, United States.

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http://dx.doi.org/10.1016/j.mce.2008.11.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2679217PMC
February 2009