William E Kraus

William E Kraus

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William E Kraus

William E Kraus

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Effects of Exercise Training With and Without Ranolazine on Peak Oxygen Consumption, Daily Physical Activity, and Quality of Life in Patients With Chronic Stable Angina Pectoris.

Am J Cardiol 2019 Sep 6;124(5):655-660. Epub 2019 Jun 6.

Duke Molecular Physiology Institute, Duke University, Durham, North Carolina; Department of Medicine, Duke University School of Medicine, Durham, North Carolina; Division of Cardiology and Urbaniak Sports Sciences Institute, Duke University School of Medicine, Durham, North Carolina.

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http://dx.doi.org/10.1016/j.amjcard.2019.05.063DOI Listing
September 2019

2 years of calorie restriction and cardiometabolic risk (CALERIE): exploratory outcomes of a multicentre, phase 2, randomised controlled trial.

Lancet Diabetes Endocrinol 2019 Sep 11;7(9):673-683. Epub 2019 Jul 11.

Department of Medicine, Washington University School of Medicine, St Louis, MO, USA; Department of Clinical and Experimental Sciences, Brescia University, Brescia, Italy; School of Medicine and Charles Perkins Centre, University of Sydney, Sydney, NSW, Australia.

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http://dx.doi.org/10.1016/S2213-8587(19)30151-2DOI Listing
September 2019

Longevity-related molecular pathways are subject to midlife "switch" in humans.

Aging Cell 2019 Aug 6;18(4):e12970. Epub 2019 Jun 6.

Department of Psychiatry and Behavioral Sciences, Center for Therapeutic Innovation, University of Miami Miller School of Medicine, Miami, Florida.

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http://dx.doi.org/10.1111/acel.12970DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6612641PMC
August 2019

The US Physical Activity Guidelines Advisory Committee Report-Introduction.

Med Sci Sports Exerc 2019 06;51(6):1203-1205

Department and School of Medicine, Duke University, Durham, NC.

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http://dx.doi.org/10.1249/MSS.0000000000001946DOI Listing
June 2019

Daily Step Counts for Measuring Physical Activity Exposure and Its Relation to Health.

Med Sci Sports Exerc 2019 06;51(6):1206-1212

Office of Disease Prevention and Health Promotion, US Department of Health and Human Services, Rockville, MD.

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http://dx.doi.org/10.1249/MSS.0000000000001932DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6527133PMC
June 2019

Association between Bout Duration of Physical Activity and Health: Systematic Review.

Med Sci Sports Exerc 2019 06;51(6):1213-1219

Office of Disease Prevention and Health Promotion, U.S. Department of Health and Human Services, Rockville, MD.

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http://dx.doi.org/10.1249/MSS.0000000000001933DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6527142PMC
June 2019

Physical Activity, All-Cause and Cardiovascular Mortality, and Cardiovascular Disease.

Med Sci Sports Exerc 2019 06;51(6):1270-1281

Office of Disease Prevention and Health Promotion, U.S. Department of Health and Human Services, Rockville, MD.

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http://dx.doi.org/10.1249/MSS.0000000000001939DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6527136PMC
June 2019

Effects of Physical Activity in Knee and Hip Osteoarthritis: A Systematic Umbrella Review.

Med Sci Sports Exerc 2019 06;51(6):1324-1339

Duke Molecular Physiology Institute, Department of Medicine, Duke University School of Medicine, Durham, NC.

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http://dx.doi.org/10.1249/MSS.0000000000001944DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6527143PMC
June 2019

Trends in cardiorespiratory fitness: The evolution of exercise treadmill testing at a single Academic Medical Center from 1970 to 2012.

Am Heart J 2019 Apr 16;210:88-97. Epub 2019 Jan 16.

Duke Clinical Research Institute, Duke Medicine, Durham, NC; Division of Cardiology, Department of Medicine, Duke University School of Medicine, Durham, NC; Duke Molecular Physiology Institute, Durham, NC.

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http://dx.doi.org/10.1016/j.ahj.2019.01.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441626PMC
April 2019

Evaluating DNA methylation age on the Illumina MethylationEPIC Bead Chip.

PLoS One 2019 19;14(4):e0207834. Epub 2019 Apr 19.

National Health and Environmental Effects Laboratory, US Environmental Protection Agency, Chapel Hill, NC, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0207834PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6474589PMC
April 2019

Ten-Year Legacy Effects of Three Eight-Month Exercise Training Programs on Cardiometabolic Health Parameters.

Front Physiol 2019 16;10:452. Epub 2019 Apr 16.

Duke Molecular Physiology Institute, Duke University Medical Center, Durham, NC, United States.

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http://dx.doi.org/10.3389/fphys.2019.00452DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6476955PMC
April 2019

Disentangling the genetics of lean mass.

Authors:
David Karasik M Carola Zillikens Yi-Hsiang Hsu Ali Aghdassi Kristina Akesson Najaf Amin Inês Barroso David A Bennett Lars Bertram Murielle Bochud Ingrid B Borecki Linda Broer Aron S Buchman Liisa Byberg Harry Campbell Natalia Campos-Obando Jane A Cauley Peggy M Cawthon John C Chambers Zhao Chen Nam H Cho Hyung Jin Choi Wen-Chi Chou Steven R Cummings Lisette C P G M de Groot Phillip L De Jager Ilja Demuth Luda Diatchenko Michael J Econs Gudny Eiriksdottir Anke W Enneman Joel Eriksson Johan G Eriksson Karol Estrada Daniel S Evans Mary F Feitosa Mao Fu Christian Gieger Harald Grallert Vilmundur Gudnason Launer J Lenore Caroline Hayward Albert Hofman Georg Homuth Kim M Huffman Lise B Husted Thomas Illig Erik Ingelsson Till Ittermann John-Olov Jansson Toby Johnson Reiner Biffar Joanne M Jordan Antti Jula Magnus Karlsson Kay-Tee Khaw Tuomas O Kilpeläinen Norman Klopp Jacqueline S L Kloth Daniel L Koller Jaspal S Kooner William E Kraus Stephen Kritchevsky Zoltán Kutalik Teemu Kuulasmaa Johanna Kuusisto Markku Laakso Jari Lahti Thomas Lang Bente L Langdahl Markus M Lerch Joshua R Lewis Christina Lill Lars Lind Cecilia Lindgren Yongmei Liu Gregory Livshits Östen Ljunggren Ruth J F Loos Mattias Lorentzon Jian'an Luan Robert N Luben Ida Malkin Fiona E McGuigan Carolina Medina-Gomez Thomas Meitinger Håkan Melhus Dan Mellström Karl Michaëlsson Braxton D Mitchell Andrew P Morris Leif Mosekilde Maria Nethander Anne B Newman Jeffery R O'Connell Ben A Oostra Eric S Orwoll Aarno Palotie Munro Peacock Markus Perola Annette Peters Richard L Prince Bruce M Psaty Katri Räikkönen Stuart H Ralston Samuli Ripatti Fernando Rivadeneira John A Robbins Jerome I Rotter Igor Rudan Veikko Salomaa Suzanne Satterfield Sabine Schipf Chan Soo Shin Albert V Smith Shad B Smith Nicole Soranzo Timothy D Spector Alena Stancáková Kari Stefansson Elisabeth Steinhagen-Thiessen Lisette Stolk Elizabeth A Streeten Unnur Styrkarsdottir Karin M A Swart Patricia Thompson Cynthia A Thomson Gudmar Thorleifsson Unnur Thorsteinsdottir Emmi Tikkanen Gregory J Tranah André G Uitterlinden Cornelia M van Duijn Natasja M van Schoor Liesbeth Vandenput Peter Vollenweider Henry Völzke Jean Wactawski-Wende Mark Walker Nicholas J Wareham Dawn Waterworth Michael N Weedon H-Erich Wichmann Elisabeth Widen Frances M K Williams James F Wilson Nicole C Wright Laura M Yerges-Armstrong Lei Yu Weihua Zhang Jing Hua Zhao Yanhua Zhou Carrie M Nielson Tamara B Harris Serkalem Demissie Douglas P Kiel Claes Ohlsson

Am J Clin Nutr 2019 Feb;109(2):276-287

Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.

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http://dx.doi.org/10.1093/ajcn/nqy272DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6500901PMC
February 2019

Lifestyle and neurocognition in older adults with cognitive impairments: A randomized trial.

Neurology 2019 Jan 19;92(3):e212-e223. Epub 2018 Dec 19.

From the Departments of Psychiatry and Behavioral Sciences (J.A.B., P.J.S., S.M., K.A.W.-B., J.N.B., P.M.D., A.S.), Medicine (P.-H.L., L.L., W.E.K., P.M.D.), and Neurology (K.A.W.-B., J.R.B.), Duke University Medical Center, Durham; and Department of Medicine (A.H.), University of North Carolina at Chapel Hill.

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http://dx.doi.org/10.1212/WNL.0000000000006784DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6340382PMC
January 2019

High-Density Lipoprotein Particle Subfractions in Heart Failure With Preserved or Reduced Ejection Fraction.

J Am Coll Cardiol 2019 Jan;73(2):177-186

Division of Cardiology, Department of Medicine, Duke University School of Medicine, Durham, North Carolina; Duke Molecular Physiology Institute, Durham, North Carolina; Duke Clinical Research Institute, Durham, North Carolina. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S07351097183918
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http://dx.doi.org/10.1016/j.jacc.2018.10.059DOI Listing
January 2019

Effects of a 12-Week mHealth Program on FunctionalCapacity and Physical Activity in Patients With PeripheralArtery Disease.

Am J Cardiol 2018 09 2;122(5):879-884. Epub 2018 Jun 2.

Duke Molecular Physiology Institute, Duke University School of Medicine, Durham, North Carolina; Division of Cardiology, Duke University School of Medicine, Durham, North Carolina.

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http://dx.doi.org/10.1016/j.amjcard.2018.05.018DOI Listing
September 2018

Genome-Wide Association Study Links Receptor Tyrosine Kinase Inhibitor Sprouty 2 to Thrombocytopenia after Coronary Artery Bypass Surgery.

Thromb Haemost 2018 Sep 13;118(9):1572-1585. Epub 2018 Aug 13.

Department of Anesthesiology, Duke Perioperative Genomics Program, Duke University Medical Center, Duke University, Durham, North Carolina, United States.

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http://dx.doi.org/10.1055/s-0038-1667199DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6428429PMC
September 2018

Beet the Best?

Circ Res 2018 Aug;123(6):654-659

Duke Molecular Physiology Institute, Duke University Medical Center, Durham, NC (M.W., M.D.V., W.E.K., J.D.A.).

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http://dx.doi.org/10.1161/CIRCRESAHA.118.313131DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6202165PMC
August 2018

The AMPK/p27 Axis Regulates Autophagy/Apoptosis Decisions in Aged Skeletal Muscle Stem Cells.

Stem Cell Reports 2018 08 19;11(2):425-439. Epub 2018 Jul 19.

Duke Molecular Physiology Institute, Duke University School of Medicine, Durham, NC 27701, USA; Duke Center for the Study of Aging and Human Development, Duke University School of Medicine, Durham, NC 27701, USA; Division of Cardiology, Duke University School of Medicine, Durham, NC 27701, USA.

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http://dx.doi.org/10.1016/j.stemcr.2018.06.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6093087PMC
August 2018

Combined Inflammation and Metabolism Biomarker Indices of Robust and Impaired Physical Function in Older Adults.

J Am Geriatr Soc 2018 Jul 8;66(7):1353-1359. Epub 2018 May 8.

Claude D. Pepper Older Americans Independence Center, Center for the Study of Aging and Human Development, Duke University Medical Center (DUMC), Duke University, Durham, North Carolina.

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http://dx.doi.org/10.1111/jgs.15393DOI Listing
July 2018

Genetic inactivation of ANGPTL4 improves glucose homeostasis and is associated with reduced risk of diabetes.

Nat Commun 2018 06 13;9(1):2252. Epub 2018 Jun 13.

Regeneron Pharmaceuticals, Tarrytown, 10591, NY, USA.

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http://dx.doi.org/10.1038/s41467-018-04611-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5997992PMC
June 2018

Relations of established aging biomarkers (IL-6, D-dimer, s-VCAM) to glomerular filtration rate and mortality in community-dwelling elderly adults.

Clin Kidney J 2018 Jun 27;11(3):377-382. Epub 2017 Sep 27.

Duke Molecular Physiology Institute, Duke University School of Medicine, Duke University, Durham, NC, USA.

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http://dx.doi.org/10.1093/ckj/sfx097DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6007338PMC
June 2018

Effects of Increasing Exercise Intensity and Dose on Multiple Measures of HDL (High-Density Lipoprotein) Function.

Arterioscler Thromb Vasc Biol 2018 04 8;38(4):943-952. Epub 2018 Feb 8.

From the Department of Exercise Science, University of South Carolina, Columbia (M.A.S., J.J.R.-R., J.L.B.); Duke Molecular Physiology Institute, Duke University School of Medicine, Durham, NC (C.A.S., R.W.M., W.E.K.); Ingestive Behavior and Preventive Medicine Laboratories, Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA (J.W.A., M.N.H., T.S.C., C.K.M.); Center for Prevention of Obesity, Cardiovascular Disease & Diabetes, Children's Hospital Oakland Research Institute, Oakland, CA (M.S.B., Y.H., M.N.O.); and Division of Cardiology, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas (A.R.).

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http://dx.doi.org/10.1161/ATVBAHA.117.310307DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5864525PMC
April 2018

Volume of Light Versus Moderate-to-Vigorous Physical Activity: Similar Benefits for All-Cause Mortality?

J Am Heart Assoc 2018 04 2;7(7). Epub 2018 Apr 2.

Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD.

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http://dx.doi.org/10.1161/JAHA.118.008815DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5907606PMC
April 2018

A Genome-Wide Association Study of Idiopathic Dilated Cardiomyopathy in African Americans.

J Pers Med 2018 02 26;8(1). Epub 2018 Feb 26.

Department of Internal Medicine and Molecular Pharmacology and Physiology, and the Center for Personalized Medicine and Genomics, University of South Florida Morsani College of Medicine, Tampa, FL 33612, USA.

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http://dx.doi.org/10.3390/jpm8010011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5872085PMC
February 2018

Associations Between Residential Proximity to Traffic and Vascular Disease in a Cardiac Catheterization Cohort.

Arterioscler Thromb Vasc Biol 2018 01 30;38(1):275-282. Epub 2017 Nov 30.

From the National Health and Environmental Effects Research Laboratory, US Environmental Protection Agency, Chapel Hill, NC (C.K.W.-C., R.D., D.D.-S., W.E.C., L.M.N.); Duke Molecular Physiology Institute, Durham, NC (W.E.K., C.B., C.S.H., E.D., S.G.G., S.H.S., E.R.H.); Division of Cardiology, Duke University School of Medicine, Durham, NC (W.E.K., S.H.S.); Department of Statistics, Rice University, Houston, TX (M.L.M.); National Exposure Research Laboratory, US Environmental Protection Agency, Research Triangle Park, NC (S.M.); Metabolon, Research Triangle Park, NC (C.S.); Alion Science and Technology, Inc., Research Triangle Park, NC (L.A.S.); and Epidemiologic Research and Information Center, Durham Veterans, Affairs Medical Center, NC (E.R.H.).

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http://dx.doi.org/10.1161/ATVBAHA.117.310003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5972827PMC
January 2018

Change in the Rate of Biological Aging in Response to Caloric Restriction: CALERIE Biobank Analysis.

J Gerontol A Biol Sci Med Sci 2017 Dec;73(1):4-10

Department of Medicine, Duke University School of Medicine, Durham, North Carolina.

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http://dx.doi.org/10.1093/gerona/glx096DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5861848PMC
December 2017

Effects of Two Years of Calorie Restriction on Aerobic Capacity and Muscle Strength.

Med Sci Sports Exerc 2017 Nov;49(11):2240-2249

1Program in Physical Therapy, Washington University School of Medicine, St. Louis, MO; 2Department of Medicine, Washington University School of Medicine, St. Louis, MO; 3Duke Clinical Research Institute, Durham, NC; 4Rho Federal Systems, Chapel Hill, NC; 5Michael E DeBakey VA Medical Center, Baylor College of Medicine, Houston, TX; 6Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA; 7Department of Clinical and Experimental Sciences, Brescia University Medical School, Brescia, Italy; 8Healthy Aging Center, CEINGE Biotecnologie Avanzate, Napoli, Italy; 9Pennington Biomedical Research Center, Baton Rouge, LA; and 10Department of Medicine and Duke Molecular Physiology Institute, Duke University School of Medicine, Durham, NC.

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http://dx.doi.org/10.1249/MSS.0000000000001353DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5647115PMC
November 2017

Erratum: Large meta-analysis of genome-wide association studies identifies five loci for lean body mass.

Authors:
M Carola Zillikens Serkalem Demissie Yi-Hsiang Hsu Laura M Yerges-Armstrong Wen-Chi Chou Lisette Stolk Gregory Livshits Linda Broer Toby Johnson Daniel L Koller Zoltán Kutalik Jian'an Luan Ida Malkin Janina S Ried Albert V Smith Gudmar Thorleifsson Liesbeth Vandenput Jing Hua Zhao Weihua Zhang Ali Aghdassi Kristina Åkesson Najaf Amin Leslie J Baier Inês Barroso David A Bennett Lars Bertram Rainer Biffar Murielle Bochud Michael Boehnke Ingrid B Borecki Aron S Buchman Liisa Byberg Harry Campbell Natalia Campos Obanda Jane A Cauley Peggy M Cawthon Henna Cederberg Zhao Chen Nam H Cho Hyung Jin Choi Melina Claussnitzer Francis Collins Steven R Cummings Philip L De Jager Ilja Demuth Rosalie A M Dhonukshe-Rutten Luda Diatchenko Gudny Eiriksdottir Anke W Enneman Mike Erdos Johan G Eriksson Joel Eriksson Karol Estrada Daniel S Evans Mary F Feitosa Mao Fu Melissa Garcia Christian Gieger Thomas Girke Nicole L Glazer Harald Grallert Jagvir Grewal Bok-Ghee Han Robert L Hanson Caroline Hayward Albert Hofman Eric P Hoffman Georg Homuth Wen-Chi Hsueh Monica J Hubal Alan Hubbard Kim M Huffman Lise B Husted Thomas Illig Erik Ingelsson Till Ittermann John-Olov Jansson Joanne M Jordan Antti Jula Magnus Karlsson Kay-Tee Khaw Tuomas O Kilpeläinen Norman Klopp Jacqueline S L Kloth Heikki A Koistinen William E Kraus Stephen Kritchevsky Teemu Kuulasmaa Johanna Kuusisto Markku Laakso Jari Lahti Thomas Lang Bente L Langdahl Lenore J Launer Jong-Young Lee Markus M Lerch Joshua R Lewis Lars Lind Cecilia Lindgren Yongmei Liu Tian Liu Youfang Liu Östen Ljunggren Mattias Lorentzon Robert N Luben William Maixner Fiona E McGuigan Carolina Medina-Gomez Thomas Meitinger Håkan Melhus Dan Mellström Simon Melov Karl Michaëlsson Braxton D Mitchell Andrew P Morris Leif Mosekilde Anne Newman Carrie M Nielson Jeffrey R O'Connell Ben A Oostra Eric S Orwoll Aarno Palotie Stephen C J Parker Munro Peacock Markus Perola Annette Peters Ozren Polasek Richard L Prince Katri Räikkönen Stuart H Ralston Samuli Ripatti John A Robbins Jerome I Rotter Igor Rudan Veikko Salomaa Suzanne Satterfield Eric E Schadt Sabine Schipf Laura Scott Joban Sehmi Jian Shen Chan Soo Shin Gunnar Sigurdsson Shad Smith Nicole Soranzo Alena Stančáková Elisabeth Steinhagen-Thiessen Elizabeth A Streeten Unnur Styrkarsdottir Karin M A Swart Sian-Tsung Tan Mark A Tarnopolsky Patricia Thompson Cynthia A Thomson Unnur Thorsteinsdottir Emmi Tikkanen Gregory J Tranah Jaakko Tuomilehto Natasja M van Schoor Arjun Verma Peter Vollenweider Henry Völzke Jean Wactawski-Wende Mark Walker Michael N Weedon Ryan Welch H-Erich Wichmann Elisabeth Widen Frances M K Williams James F Wilson Nicole C Wright Weijia Xie Lei Yu Yanhua Zhou John C Chambers Angela Döring Cornelia M van Duijn Michael J Econs Vilmundur Gudnason Jaspal S Kooner Bruce M Psaty Timothy D Spector Kari Stefansson Fernando Rivadeneira André G Uitterlinden Nicholas J Wareham Vicky Ossowski Dawn Waterworth Ruth J F Loos David Karasik Tamara B Harris Claes Ohlsson Douglas P Kiel

Nat Commun 2017 11 7;8(1):1414. Epub 2017 Nov 7.

Hebrew SeniorLife, Institute for Aging Research, Roslindale, MA, 02131, USA.

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http://dx.doi.org/10.1038/s41467-017-01008-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5676783PMC
November 2017

Rheumatoid arthritis complicates noninvasive whole blood gene expression testing for coronary artery disease.

Am Heart J 2017 Oct 2;192:13-18. Epub 2017 Jul 2.

Division of Rheumatology and Immunology, Duke University Medical Center, Durham, NC; Duke Molecular Physiology Institute, Duke University Medical Center, Durham, NC; Durham VA Medical Center, Durham, NC.

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http://dx.doi.org/10.1016/j.ahj.2017.06.013DOI Listing
October 2017

Combined Dietary Nitrate and Exercise Intervention in Peripheral Artery Disease: Protocol Rationale and Design.

JMIR Res Protoc 2017 Oct 3;6(10):e139. Epub 2017 Oct 3.

Clinical Exercise Science Research Program, Institute of Sport, Exercise and Active Living, Victoria University, Melbourne, Australia.

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http://dx.doi.org/10.2196/resprot.7596DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5645641PMC
October 2017

Genetic and Pharmacologic Inactivation of ANGPTL3 and Cardiovascular Disease.

N Engl J Med 2017 07 24;377(3):211-221. Epub 2017 May 24.

From Regeneron Genetics Center (F.E.D., C.O., C.S., O.G., S.M., C.V.V.H., S.B., L.H., A.L., J.P., N.S., A.J.M., J.D.O., J.G.R., A.R.S., I.B.B., T.M.T., G.D.Y., S.J.M., A. Baras) and Regeneron Pharmaceuticals (V.G., H.M.D., A.Z., W.S., N.S., A.J.M., S.H., A. Bouzelmat, R.Z., B.S., R.P., D.G., G.A.H., W.J.S., P.B., G.D.Y., S.J.M., J.G.) Tarrytown, NY; the Department of Medicine, Division of Translational Medicine and Human Genetics (R.L.D.), and Departments of Surgery (S.D.) and Genetics and Medicine (A.S., D.J.R.), Perelman School of Medicine, University of Pennsylvania, Philadelphia, and Geisinger Health System, Danville (J.B.L., M.F.M., M.D.R., H.L.K., D.H.L., D.J.C.) - both in Pennsylvania; the Division of Endocrinology and Metabolism, Department of Internal Medicine (W.H.H.S., I.-T.L.) and Cardiovascular Center (K.-W.L.), Taichung Veterans General Hospital, Institute of Medical Technology, National Chung-Hsing University (W.H.H.S.), School of Medicine, Chung Shan Medical University (I.-T.L.), and the Department of Medicine, China Medical University (K.-W.L.), Taichung, and School of Medicine, National Yang-Ming University (W.H.H.S., I.-T.L., K.-W.L.), and School of Medicine, National Defense Medical Center (W.H.H.S.), Taipei - all in Taiwan; Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute and Department of Pediatrics, Harbor-UCLA Medical Center, Torrance, CA (X.G., J.I.R., Y.-D.I.C.); the Division of Cardiology, Department of Medicine, Molecular Physiology Institute, School of Medicine, Duke University, Durham, NC (W.E.K., S.H.S.); the Department of Clinical Biochemistry, Rigshospitalet (A.B.W., B.G.N., A.T.-H.), the Copenhagen General Population Study (B.G.N., A.T.-H.) and Department of Clinical Biochemistry (B.G.N.), Herlev and Gentofte Hospital, and the Copenhagen City Heart Study, Frederiksberg Hospital, Copenhagen University Hospital, and Faculty of Health and Medical Sciences, University of Copenhagen (B.G.N., A.T.-H.) - all in Copenhagen; and TNO Metabolic Health Research, Gaubius Laboratory, Leiden, the Netherlands (A.M.H., H.M.G.P.).

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http://dx.doi.org/10.1056/NEJMoa1612790DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5800308PMC
July 2017

Large meta-analysis of genome-wide association studies identifies five loci for lean body mass.

Authors:
M Carola Zillikens Serkalem Demissie Yi-Hsiang Hsu Laura M Yerges-Armstrong Wen-Chi Chou Lisette Stolk Gregory Livshits Linda Broer Toby Johnson Daniel L Koller Zoltán Kutalik Jian'an Luan Ida Malkin Janina S Ried Albert V Smith Gudmar Thorleifsson Liesbeth Vandenput Jing Hua Zhao Weihua Zhang Ali Aghdassi Kristina Åkesson Najaf Amin Leslie J Baier Inês Barroso David A Bennett Lars Bertram Rainer Biffar Murielle Bochud Michael Boehnke Ingrid B Borecki Aron S Buchman Liisa Byberg Harry Campbell Natalia Campos Obanda Jane A Cauley Peggy M Cawthon Henna Cederberg Zhao Chen Nam H Cho Hyung Jin Choi Melina Claussnitzer Francis Collins Steven R Cummings Philip L De Jager Ilja Demuth Rosalie A M Dhonukshe-Rutten Luda Diatchenko Gudny Eiriksdottir Anke W Enneman Mike Erdos Johan G Eriksson Joel Eriksson Karol Estrada Daniel S Evans Mary F Feitosa Mao Fu Melissa Garcia Christian Gieger Thomas Girke Nicole L Glazer Harald Grallert Jagvir Grewal Bok-Ghee Han Robert L Hanson Caroline Hayward Albert Hofman Eric P Hoffman Georg Homuth Wen-Chi Hsueh Monica J Hubal Alan Hubbard Kim M Huffman Lise B Husted Thomas Illig Erik Ingelsson Till Ittermann John-Olov Jansson Joanne M Jordan Antti Jula Magnus Karlsson Kay-Tee Khaw Tuomas O Kilpeläinen Norman Klopp Jacqueline S L Kloth Heikki A Koistinen William E Kraus Stephen Kritchevsky Teemu Kuulasmaa Johanna Kuusisto Markku Laakso Jari Lahti Thomas Lang Bente L Langdahl Lenore J Launer Jong-Young Lee Markus M Lerch Joshua R Lewis Lars Lind Cecilia Lindgren Yongmei Liu Tian Liu Youfang Liu Östen Ljunggren Mattias Lorentzon Robert N Luben William Maixner Fiona E McGuigan Carolina Medina-Gomez Thomas Meitinger Håkan Melhus Dan Mellström Simon Melov Karl Michaëlsson Braxton D Mitchell Andrew P Morris Leif Mosekilde Anne Newman Carrie M Nielson Jeffrey R O'Connell Ben A Oostra Eric S Orwoll Aarno Palotie Stephen C J Parker Munro Peacock Markus Perola Annette Peters Ozren Polasek Richard L Prince Katri Räikkönen Stuart H Ralston Samuli Ripatti John A Robbins Jerome I Rotter Igor Rudan Veikko Salomaa Suzanne Satterfield Eric E Schadt Sabine Schipf Laura Scott Joban Sehmi Jian Shen Chan Soo Shin Gunnar Sigurdsson Shad Smith Nicole Soranzo Alena Stančáková Elisabeth Steinhagen-Thiessen Elizabeth A Streeten Unnur Styrkarsdottir Karin M A Swart Sian-Tsung Tan Mark A Tarnopolsky Patricia Thompson Cynthia A Thomson Unnur Thorsteinsdottir Emmi Tikkanen Gregory J Tranah Jaakko Tuomilehto Natasja M van Schoor Arjun Verma Peter Vollenweider Henry Völzke Jean Wactawski-Wende Mark Walker Michael N Weedon Ryan Welch H-Erich Wichmann Elisabeth Widen Frances M K Williams James F Wilson Nicole C Wright Weijia Xie Lei Yu Yanhua Zhou John C Chambers Angela Döring Cornelia M van Duijn Michael J Econs Vilmundur Gudnason Jaspal S Kooner Bruce M Psaty Timothy D Spector Kari Stefansson Fernando Rivadeneira André G Uitterlinden Nicholas J Wareham Vicky Ossowski Dawn Waterworth Ruth J F Loos David Karasik Tamara B Harris Claes Ohlsson Douglas P Kiel

Nat Commun 2017 07 19;8(1):80. Epub 2017 Jul 19.

Hebrew SeniorLife, Institute for Aging Research, Roslindale, MA, 02131, USA.

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http://dx.doi.org/10.1038/s41467-017-00031-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5517526PMC
July 2017

Corrigendum to 'Association of Standard Clinical and Laboratory Variables with Red Blood Cell Distribution Width (RDW)'[Am. Heart J. (2016) 22-28].

Am Heart J 2017 06;188:196

Duke Clinical Research Institute, Duke University Medical Center, Durham, NC, USA; Duke Division of Cardiology, Duke University Medical Center, Durham, NC, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ahj.2017.05.011DOI Listing
June 2017

Human, Tissue-Engineered, Skeletal Muscle Myobundles to Measure Oxygen Uptake and Assess Mitochondrial Toxicity.

Tissue Eng Part C Methods 2017 04 24;23(4):189-199. Epub 2017 Mar 24.

1 Department of Biomedical Engineering, Duke University , Durham, North Carolina.

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http://dx.doi.org/10.1089/ten.tec.2016.0264DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5397214PMC
April 2017

Exercise Training in Patients With Chronic Heart Failure and Atrial Fibrillation.

J Am Coll Cardiol 2017 Apr;69(13):1683-1691

Division of Cardiology, Department of Medicine, Duke University Medical Center, Durham, North Carolina; Duke Clinical Research Institute, Durham, North Carolina.

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http://dx.doi.org/10.1016/j.jacc.2017.01.032DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5380238PMC
April 2017

ANGPTL3 Deficiency and Protection Against Coronary Artery Disease.

J Am Coll Cardiol 2017 Apr 3;69(16):2054-2063. Epub 2017 Apr 3.

Center for Human Genetic Research, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts; Cardiovascular Research Center and Cardiology Division, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts; Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts. Electronic address:

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http://dx.doi.org/10.1016/j.jacc.2017.02.030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5404817PMC
April 2017

Plasma acylcarnitines are associated with pulmonary hypertension.

Pulm Circ 2017 Mar 1;7(1):211-218. Epub 2017 Feb 1.

Division of Cardiology, Department of Medicine, Duke University Medical Center, Durham, NC, USA.

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http://dx.doi.org/10.1086/690554DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5448546PMC
March 2017

Does a lack of physical activity explain the rheumatoid arthritis lipid profile?

Lipids Health Dis 2017 Feb 10;16(1):39. Epub 2017 Feb 10.

Department of Medicine and Duke Molecular Physiology Institute, Duke School of Medicine, Durham, NC, USA.

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http://dx.doi.org/10.1186/s12944-017-0427-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5303308PMC
February 2017

Systematic Evaluation of Pleiotropy Identifies 6 Further Loci Associated With Coronary Artery Disease.

Authors:
Thomas R Webb Jeanette Erdmann Kathleen E Stirrups Nathan O Stitziel Nicholas G D Masca Henning Jansen Stavroula Kanoni Christopher P Nelson Paola G Ferrario Inke R König John D Eicher Andrew D Johnson Stephen E Hamby Christer Betsholtz Arno Ruusalepp Oscar Franzén Eric E Schadt Johan L M Björkegren Peter E Weeke Paul L Auer Ursula M Schick Yingchang Lu He Zhang Marie-Pierre Dube Anuj Goel Martin Farrall Gina M Peloso Hong-Hee Won Ron Do Erik van Iperen Jochen Kruppa Anubha Mahajan Robert A Scott Christina Willenborg Peter S Braund Julian C van Capelleveen Alex S F Doney Louise A Donnelly Rosanna Asselta Pier A Merlini Stefano Duga Nicola Marziliano Josh C Denny Christian Shaffer Nour Eddine El-Mokhtari Andre Franke Stefanie Heilmann Christian Hengstenberg Per Hoffmann Oddgeir L Holmen Kristian Hveem Jan-Håkan Jansson Karl-Heinz Jöckel Thorsten Kessler Jennifer Kriebel Karl L Laugwitz Eirini Marouli Nicola Martinelli Mark I McCarthy Natalie R Van Zuydam Christa Meisinger Tõnu Esko Evelin Mihailov Stefan A Escher Maris Alver Susanne Moebus Andrew D Morris Jarma Virtamo Majid Nikpay Oliviero Olivieri Sylvie Provost Alaa AlQarawi Neil R Robertson Karen O Akinsansya Dermot F Reilly Thomas F Vogt Wu Yin Folkert W Asselbergs Charles Kooperberg Rebecca D Jackson Eli Stahl Martina Müller-Nurasyid Konstantin Strauch Tibor V Varga Melanie Waldenberger Lingyao Zeng Rajiv Chowdhury Veikko Salomaa Ian Ford J Wouter Jukema Philippe Amouyel Jukka Kontto Børge G Nordestgaard Jean Ferrières Danish Saleheen Naveed Sattar Praveen Surendran Aline Wagner Robin Young Joanna M M Howson Adam S Butterworth John Danesh Diego Ardissino Erwin P Bottinger Raimund Erbel Paul W Franks Domenico Girelli Alistair S Hall G Kees Hovingh Adnan Kastrati Wolfgang Lieb Thomas Meitinger William E Kraus Svati H Shah Ruth McPherson Marju Orho-Melander Olle Melander Andres Metspalu Colin N A Palmer Annette Peters Daniel J Rader Muredach P Reilly Ruth J F Loos Alex P Reiner Dan M Roden Jean-Claude Tardif John R Thompson Nicholas J Wareham Hugh Watkins Cristen J Willer Nilesh J Samani Heribert Schunkert Panos Deloukas Sekar Kathiresan

J Am Coll Cardiol 2017 Feb;69(7):823-836

Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts; Cardiovascular Research Center, Massachusetts General Hospital, Boston, Massachusetts; Department of Medicine, Harvard Medical School, Boston, Massachusetts; Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts; Cardiology Division, Massachusetts General Hospital, Boston, Massachusetts.

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http://dx.doi.org/10.1016/j.jacc.2016.11.056DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5314135PMC
February 2017

The Effect of Vigorous- Versus Moderate-Intensity Aerobic Exercise on Insulin Action.

Curr Cardiol Rep 2016 12;18(12):117

Duke Molecular Physiology Institute, Duke University Medical Center, 300 North Duke Street, Durham, NC, 27701, USA.

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http://dx.doi.org/10.1007/s11886-016-0797-7DOI Listing
December 2016

Pyruvate Dehydrogenase Phosphatase Regulatory Gene Expression Correlates with Exercise Training Insulin Sensitivity Changes.

Med Sci Sports Exerc 2016 12;48(12):2387-2397

1Research Center for Genetic Medicine, Children's National Medical Center, Durham, NC; 2Division of Rheumatology, Department of Medicine, Duke University School of Medicine, Durham, NC; 3Duke Molecular Physiology Institute, Duke University School of Medicine, Durham, NC; 4Department of Exercise and Nutrition Sciences, George Washington University, WASHINGTON, DC; 5Division of Cardiology, Department of Medicine, Duke University School of Medicine, Durham, NC; and 6Department of Integrative Systems Biology, George Washington University, Washington, DC.

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http://dx.doi.org/10.1249/MSS.0000000000001041DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5141615PMC
December 2016

Application of the Marginal Structural Model to Account for Suboptimal Adherence in a Randomized Controlled Trial.

Contemp Clin Trials Commun 2016 Dec 3;4:222-228. Epub 2016 Nov 3.

Duke Clinical Research Institute, 2400 Pratt Street, Durham, NC 27710, USA; Duke Molecular Physiology Institute, 300 North Duke Street, Durham, NC 27701, USA.

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http://dx.doi.org/10.1016/j.conctc.2016.10.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5124349PMC
December 2016

Short-term effects of air temperature on plasma metabolite concentrations in patients undergoing cardiac catheterization.

Environ Res 2016 Nov 6;151:224-232. Epub 2016 Aug 6.

Institute of Epidemiology II, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), Ingolstädter Landstraße 1, 85764 Neuherberg, Germany.

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http://dx.doi.org/10.1016/j.envres.2016.07.010DOI Listing
November 2016

Relation of Angina Pectoris to Outcomes, Quality of Life, and Response to Exercise Training in Patients With Chronic Heart Failure (from HF-ACTION).

Am J Cardiol 2016 Oct 29;118(8):1211-1216. Epub 2016 Jul 29.

Duke Clinical Research Institute, Durham, North Carolina; Division of Cardiology, Department of Medicine, Duke University Medical Center, Durham, North Carolina.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5050169PMC
http://dx.doi.org/10.1016/j.amjcard.2016.07.040DOI Listing
October 2016

Statins and Exercise Training Response in Heart Failure Patients: Insights From HF-ACTION.

JACC Heart Fail 2016 08 6;4(8):617-24. Epub 2016 Jul 6.

Division of Cardiology, Department of Medicine, Duke University Medical Center, Durham, North Carolina; Duke Clinical Research Institute, Durham, North Carolina.

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http://dx.doi.org/10.1016/j.jchf.2016.05.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5429584PMC
August 2016

Deaths in triathletes: immersion pulmonary oedema as a possible cause.

BMJ Open Sport Exerc Med 2016 29;2(1):e000146. Epub 2016 Aug 29.

Department of Medicine, Division of Cardiology , Duke Molecular Physiology Institute, Duke University Medical Center , Durham, North Carolina , USA.

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http://dx.doi.org/10.1136/bmjsem-2016-000146DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5117085PMC
August 2016