William E Klunk

William E Klunk

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William E Klunk

William E Klunk

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Leisure Activity, Brain β-amyloid, and Episodic Memory in Adults with Down Syndrome.

Dev Neurobiol 2019 07 1;79(7):738-749. Epub 2019 Apr 1.

Waisman Center, University of Wisconsin-Madison, Madison, Wisconsin.

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http://dx.doi.org/10.1002/dneu.22677DOI Listing
July 2019

Neuropathological correlates of amyloid PET imaging in Down syndrome.

Dev Neurobiol 2019 07 17;79(7):750-766. Epub 2019 Aug 17.

Geriatric Research Education and Clinical Center, VA Pittsburgh Healthcare System, Pittsburgh, Pennsylvania.

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http://dx.doi.org/10.1002/dneu.22713DOI Listing
July 2019

Fluid and PET biomarkers for amyloid pathology in Alzheimer's disease.

Mol Cell Neurosci 2019 Jun 8;97:3-17. Epub 2018 Dec 8.

Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Molndal, Sweden; Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy at the University of Gothenburg, University College, London, United Kingdom of Great Britain and Northern Ireland; Department of Molecular Neuroscience, UCL Institute of Neurology, United Kingdom of Great Britain and Northern Ireland; UK Dementia Research Institute at UCL, United Kingdom of Great Britain and Northern Ireland.

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http://dx.doi.org/10.1016/j.mcn.2018.12.004DOI Listing
June 2019

Amyloid deposition is associated with different patterns of hippocampal connectivity in men versus women.

Neurobiol Aging 2019 04 1;76:141-150. Epub 2018 Dec 1.

Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA; Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neurobiolaging.2018.11.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6584958PMC
April 2019

Impact of partial volume correction on the regional correspondence between in vivo [C-11]PiB PET and postmortem measures of Aβ load.

Neuroimage Clin 2018 4;19:182-189. Epub 2018 Apr 4.

Department of Neurology, University of Pittsburgh, Pittsburgh, PA, USA; Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA; Geriatric Research Education and Clinical Center, Veterans Affairs Pittsburgh Healthcare System, Pittsburgh, PA, USA.

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http://dx.doi.org/10.1016/j.nicl.2018.04.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6050460PMC
January 2019

Utilizing the Centiloid scale in cross-sectional and longitudinal PiB PET studies.

Neuroimage Clin 2018 25;19:406-416. Epub 2018 Apr 25.

Department of Radiology, Washington University School of Medicine, Saint Louis, MO 63110, USA; Knight Alzheimer Disease Research Center, Washington University School of Medicine, Saint Louis, MO 63110, USA.

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http://dx.doi.org/10.1016/j.nicl.2018.04.022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6051499PMC
January 2019

Research Use of Ecological Momentary Assessment for Adverse Event Monitoring Following Amyloid-β Results Disclosure.

J Alzheimers Dis 2019 ;71(4):1071-1079

Department of Health and Community Systems, University of Pittsburgh School of Nursing, Pittsburgh, PA, USA.

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http://dx.doi.org/10.3233/JAD-190091DOI Listing
January 2019

Standardization of amyloid quantitation with florbetapir standardized uptake value ratios to the Centiloid scale.

Alzheimers Dement 2018 12 11;14(12):1565-1571. Epub 2018 Jul 11.

Avid Radiopharmaceuticals, Philadelphia, PA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jalz.2018.06.1353DOI Listing
December 2018

Synergism of antihypertensives and cholinesterase inhibitors in Alzheimer's disease.

Alzheimers Dement (N Y) 2018 14;4:542-555. Epub 2018 Oct 14.

Department of Pharmaceutical Sciences and Computational Chemical Genomics Screening Center, School of Pharmacy; NIDA National Center of Excellence for Computational Drug Abuse Research, University of Pittsburgh, Pittsburgh, PA, USA.

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http://dx.doi.org/10.1016/j.trci.2018.09.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6205113PMC
October 2018

Prevalence of the apolipoprotein E ε4 allele in amyloid β positive subjects across the spectrum of Alzheimer's disease.

Authors:
Niklas Mattsson Colin Groot Willemijn J Jansen Susan M Landau Victor L Villemagne Sebastiaan Engelborghs Mark M Mintun Alberto Lleo José Luis Molinuevo William J Jagust Giovanni B Frisoni Adrian Ivanoiu Gaël Chételat Catarina Resende de Oliveira Karen M Rodrigue Johannes Kornhuber Anders Wallin Aleksandra Klimkowicz-Mrowiec Ramesh Kandimalla Julius Popp Pauline P Aalten Dag Aarsland Daniel Alcolea Ina S Almdahl Inês Baldeiras Mark A van Buchem Enrica Cavedo Kewei Chen Ann D Cohen Stefan Förster Juan Fortea Kristian S Frederiksen Yvonne Freund-Levi Kiran Dip Gill Olymbia Gkatzima Timo Grimmer Harald Hampel Sanna-Kaisa Herukka Peter Johannsen Koen van Laere Mony J de Leon Wolfgang Maier Jan Marcusson Olga Meulenbroek Hanne M Møllergård John C Morris Barbara Mroczko Arto Nordlund Sudesh Prabhakar Oliver Peters Lorena Rami Eloy Rodríguez-Rodríguez Catherine M Roe Eckart Rüther Isabel Santana Johannes Schröder Sang W Seo Hilkka Soininen Luiza Spiru Erik Stomrud Hanne Struyfs Charlotte E Teunissen Frans R J Verhey Stephanie J B Vos Linda J C van Waalwijk van Doorn Gunhild Waldemar Åsa K Wallin Jens Wiltfang Rik Vandenberghe David J Brooks Tormod Fladby Christopher C Rowe Alexander Drzezga Marcel M Verbeek Marie Sarazin David A Wolk Adam S Fleisher William E Klunk Duk L Na Pascual Sánchez-Juan Dong Young Lee Agneta Nordberg Magda Tsolaki Vincent Camus Juha O Rinne Anne M Fagan Henrik Zetterberg Kaj Blennow Gil D Rabinovici Oskar Hansson Bart N M van Berckel Wiesje M van der Flier Philip Scheltens Pieter Jelle Visser Rik Ossenkoppele

Alzheimers Dement 2018 07 28;14(7):913-924. Epub 2018 Mar 28.

Clinical Memory Research Unit, Clinical Sciences Malmö, Lund University, Lund, Sweden; Department of Neurology and Alzheimer Center, VU University Medical Center, Neuroscience Campus Amsterdam, Amsterdam, the Netherlands; Department of Radiology and Nuclear Medicine, VU University Medical Center, Neuroscience Campus Amsterdam, Amsterdam, the Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.jalz.2018.02.009DOI Listing
July 2018

Amyloid deposition and brain structure as long-term predictors of MCI, dementia, and mortality.

Neurology 2018 05 25;90(21):e1920-e1928. Epub 2018 Apr 25.

From the Departments of Neurology (O.L.L., J.T.B., B.S., M.I.), Psychiatry (O.L.L., J.T.B., W.E.K., H.J.A., A.D.C.), Psychology (J.T.B.), Neurosurgery (Y.C.), Epidemiology, Graduate School of Public Health (Y.C., L.H.K.), Radiology (C.M., J.P.), Pharmaceutical Sciences (C.M.), and Genetics (M.I.K.), University of Pittsburgh, School of Medicine, PA; and Department of Neurology (S.T.D.), University of Florida, Gainesville.

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http://dx.doi.org/10.1212/WNL.0000000000005549DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5962915PMC
May 2018

Molecular imaging: What is right and what is an illusion?

Authors:
William E Klunk

Alzheimers Dement (Amst) 2018 10;10:217-220. Epub 2018 Feb 10.

University of Pittsburgh, Pittsburgh, PA, USA.

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http://dx.doi.org/10.1016/j.dadm.2018.01.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5956935PMC
February 2018

Association of Cerebral Amyloid-β Aggregation With Cognitive Functioning in Persons Without Dementia.

Authors:
Willemijn J Jansen Rik Ossenkoppele Betty M Tijms Anne M Fagan Oskar Hansson William E Klunk Wiesje M van der Flier Victor L Villemagne Giovanni B Frisoni Adam S Fleisher Alberto Lleó Mark A Mintun Anders Wallin Sebastiaan Engelborghs Duk L Na Gäel Chételat José Luis Molinuevo Susan M Landau Niklas Mattsson Johannes Kornhuber Osama Sabri Christopher C Rowe Lucilla Parnetti Julius Popp Tormod Fladby William J Jagust Pauline Aalten Dong Young Lee Rik Vandenberghe Catarina Resende de Oliveira Elisabeth Kapaki Lutz Froelich Adrian Ivanoiu Tomasz Gabryelewicz Marcel M Verbeek Páscual Sanchez-Juan Helmut Hildebrandt Vincent Camus Marzena Zboch David J Brooks Alexander Drzezga Juha O Rinne Andrew Newberg Alexandre de Mendonça Marie Sarazin Gil D Rabinovici Karine Madsen Milica G Kramberger Agneta Nordberg Vincent Mok Barbara Mroczko David A Wolk Philipp T Meyer Magda Tsolaki Philip Scheltens Frans R J Verhey Pieter Jelle Visser Dag Aarsland Daniel Alcolea Myriam Alexander Ina S Almdahl Steven E Arnold Inês Baldeiras Henryk Barthel Bart N M van Berckel Kaj Blennow Mark A van Buchem Enrica Cavedo Kewei Chen Elena Chipi Ann D Cohen Stefan Förster Juan Fortea Kristian S Frederiksen Yvonne Freund-Levi Olymbia Gkatzima Mark Forrest Gordon Timo Grimmer Harald Hampel Lucrezia Hausner Sabine Hellwig Sanna-Kaisa Herukka Peter Johannsen Aleksandra Klimkowicz-Mrowiec Sebastian Köhler Norman Koglin Koen van Laere Mony de Leon Viviana Lisetti Wolfgang Maier Jan Marcusson Olga Meulenbroek Hanne M Møllergård John C Morris Arto Nordlund Gerald P Novak George P Paraskevas Gayan Perera Oliver Peters Inez H G B Ramakers Lorena Rami Eloy Rodríguez-Rodríguez Catherine M Roe Uros Rot Eckart Rüther Isabel Santana Johannes Schröder Sang W Seo Hilkka Soininen Luiza Spiru Erik Stomrud Hanne Struyfs Charlotte E Teunissen Stephanie J B Vos Linda J C van Waalwijk van Doorn Gunhild Waldemar Åsa K Wallin Jens Wiltfang Henrik Zetterberg

JAMA Psychiatry 2018 01;75(1):84-95

Institute of Neuroscience and Physiology, Sahlgrenska Academy at University of Gothenburg, Mölndal, Sweden.

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http://dx.doi.org/10.1001/jamapsychiatry.2017.3391DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5786156PMC
January 2018

Cognitive decline and brain amyloid-β accumulation across 3 years in adults with Down syndrome.

Neurobiol Aging 2017 10 2;58:68-76. Epub 2017 Jun 2.

University of Wisconsin-Madison, Waisman Center, Madison, WI, USA; Department of Medical Physics, University of Wisconsin-Madison, Madison, WI, USA.

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http://dx.doi.org/10.1016/j.neurobiolaging.2017.05.019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5581712PMC
October 2017

Small-molecule PET Tracers for Imaging Proteinopathies.

Semin Nucl Med 2017 09 13;47(5):553-575. Epub 2017 Jul 13.

Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA.

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http://dx.doi.org/10.1053/j.semnuclmed.2017.06.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5657567PMC
September 2017

Association of Brain Amyloid-β With Slow Gait in Elderly Individuals Without Dementia: Influence of Cognition and Apolipoprotein E ε4 Genotype.

JAMA Neurol 2017 Jan;74(1):82-90

Alzheimer's Disease Research Center, University of Pittsburgh, Pittsburgh, Pennsylvania4Department of Neurology, University of Pittsburgh, Pittsburgh, Pennsylvania.

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http://dx.doi.org/10.1001/jamaneurol.2016.3474DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5735996PMC
January 2017

Tenascin-C Is Associated with Cored Amyloid-β Plaques in Alzheimer Disease and Pathology Burdened Cognitively Normal Elderly.

J Neuropathol Exp Neurol 2016 09 21;75(9):868-76. Epub 2016 Jul 21.

From the Departments of Neurology (ZM, EEA, WEK, MDI)Department of Neurobiology (WH)Department of Psychiatry (WEK, MDI)Department of Radiology, University of Pittsburgh (CAM)Department of Geriatric Research Education and Clinical Center, VA Pittsburgh Healthcare System (ZM, EEA, MDI)Department of Neurobiology, Barrow Neurological Institute, Pittsburgh, PA, USA (EJM)

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http://dx.doi.org/10.1093/jnen/nlw062DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5909866PMC
September 2016

[F-18]AV-1451 positron emission tomography retention in choroid plexus: More than "off-target" binding.

Ann Neurol 2016 08 7;80(2):307-8. Epub 2016 Jul 7.

Departments of Neurology, University of Pittsburgh, VA Pittsburgh HS, Pittsburgh, PA.

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http://dx.doi.org/10.1002/ana.24706DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4982815PMC
August 2016

The effects of normal aging on amyloid-β deposition in nondemented adults with Down syndrome as imaged by carbon 11-labeled Pittsburgh compound B.

Alzheimers Dement 2016 Apr 13;12(4):380-90. Epub 2015 Jun 13.

Department of Medical Physics, University of Wisconsin Madison, Madison, WI, USA; Waisman Center, University of Wisconsin Madison, Madison, WI, USA; Department of Psychiatry, University of Wisconsin Madison, Madison, WI, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jalz.2015.05.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4677061PMC
April 2016

More evidence for association of a rare TREM2 mutation (R47H) with Alzheimer's disease risk.

Neurobiol Aging 2015 Aug 25;36(8):2443.e21-6. Epub 2015 Apr 25.

Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neurobiolaging.2015.04.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4465085PMC
August 2015

Amyloid-β 11C-PiB-PET imaging results from 2 randomized bapineuzumab phase 3 AD trials.

Neurology 2015 Aug 24;85(8):692-700. Epub 2015 Jul 24.

From Janssen Alzheimer Immunotherapy Research & Development, LLC (E.L., R.M., P.C., K.M.G., J.D., Y.L., I.C.T., S.B., E.Y., H.R.B.), South San Francisco, CA; Janssen Pharmaceutical (M.E.S.), Beerse, NV; Brigham & Women's Hospital (R.S.), Boston, MA; University of Michigan (R.K.), Ann Arbor; University of Pittsburgh (N.S.M., W.E.K., C.A.M.), PA; Butler Hospital (S.S.), Providence, RI; UCL Institute of Neurology (N.C.F.), London, UK; IXICO plc (D.L.H., A.S.L.), London, UK; Pfizer Inc. (B.T.W.), Groton, CT; Pfizer Inc. (K.B.), Collegeville, PA; Global R&D Partners, LLC (M.G.), San Diego, CA; and University of California (M.G.), San Diego.

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http://dx.doi.org/10.1212/WNL.0000000000001877DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4553028PMC
August 2015

Endogenous murine Aβ increases amyloid deposition in APP23 but not in APPPS1 transgenic mice.

Neurobiol Aging 2015 Jul 25;36(7):2241-2247. Epub 2015 Mar 25.

Department of Cellular Neurology, Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany; DZNE, German Center for Neurodegenerative Diseases, Tübingen, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.neurobiolaging.2015.03.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4457564PMC
July 2015

A survey of attitudes toward clinical trials and genetic disclosure in autosomal dominant Alzheimer's disease.

Alzheimers Res Ther 2015 22;7(1):50. Epub 2015 Jul 22.

Mary S. Easton Center for Alzheimer's Disease Research, Department of Neurology, University of California, 10911 Weyburn Ave, Ste 200, Los Angeles, CA 90095 USA.

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http://dx.doi.org/10.1186/s13195-015-0135-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4511231PMC
July 2015

Prevalence of cerebral amyloid pathology in persons without dementia: a meta-analysis.

Authors:
Willemijn J Jansen Rik Ossenkoppele Dirk L Knol Betty M Tijms Philip Scheltens Frans R J Verhey Pieter Jelle Visser Pauline Aalten Dag Aarsland Daniel Alcolea Myriam Alexander Ina S Almdahl Steven E Arnold Inês Baldeiras Henryk Barthel Bart N M van Berckel Kristen Bibeau Kaj Blennow David J Brooks Mark A van Buchem Vincent Camus Enrica Cavedo Kewei Chen Gael Chetelat Ann D Cohen Alexander Drzezga Sebastiaan Engelborghs Anne M Fagan Tormod Fladby Adam S Fleisher Wiesje M van der Flier Lisa Ford Stefan Förster Juan Fortea Nadia Foskett Kristian S Frederiksen Yvonne Freund-Levi Giovanni B Frisoni Lutz Froelich Tomasz Gabryelewicz Kiran Dip Gill Olymbia Gkatzima Estrella Gómez-Tortosa Mark Forrest Gordon Timo Grimmer Harald Hampel Lucrezia Hausner Sabine Hellwig Sanna-Kaisa Herukka Helmut Hildebrandt Lianna Ishihara Adrian Ivanoiu William J Jagust Peter Johannsen Ramesh Kandimalla Elisabeth Kapaki Aleksandra Klimkowicz-Mrowiec William E Klunk Sebastian Köhler Norman Koglin Johannes Kornhuber Milica G Kramberger Koen Van Laere Susan M Landau Dong Young Lee Mony de Leon Viviana Lisetti Alberto Lleó Karine Madsen Wolfgang Maier Jan Marcusson Niklas Mattsson Alexandre de Mendonça Olga Meulenbroek Philipp T Meyer Mark A Mintun Vincent Mok José Luis Molinuevo Hanne M Møllergård John C Morris Barbara Mroczko Stefan Van der Mussele Duk L Na Andrew Newberg Agneta Nordberg Arto Nordlund Gerald P Novak George P Paraskevas Lucilla Parnetti Gayan Perera Oliver Peters Julius Popp Sudesh Prabhakar Gil D Rabinovici Inez H G B Ramakers Lorena Rami Catarina Resende de Oliveira Juha O Rinne Karen M Rodrigue Eloy Rodríguez-Rodríguez Catherine M Roe Uros Rot Christopher C Rowe Eckart Rüther Osama Sabri Páscual Sanchez-Juan Isabel Santana Marie Sarazin Johannes Schröder Christin Schütte Sang W Seo Femke Soetewey Hilkka Soininen Luiza Spiru Hanne Struyfs Charlotte E Teunissen Magda Tsolaki Rik Vandenberghe Marcel M Verbeek Victor L Villemagne Stephanie J B Vos Linda J C van Waalwijk van Doorn Gunhild Waldemar Anders Wallin Åsa K Wallin Jens Wiltfang David A Wolk Marzena Zboch Henrik Zetterberg

JAMA 2015 May;313(19):1924-38

Institute of Neuroscience and Physiology, Sahlgrenska Academy at University of Gothenburg, Mölndal, Sweden87UCL Institute of Neurology, Queen Square, London, United Kingdom.

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http://dx.doi.org/10.1001/jama.2015.4668DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4486209PMC
May 2015

Early detection of Alzheimer's disease using PiB and FDG PET.

Neurobiol Dis 2014 Dec 10;72 Pt A:117-22. Epub 2014 May 10.

Department of Psychiatry, University of Pittsburgh School of Medicine, USA; Department of Neurology, University of Pittsburgh School of Medicine, USA.

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http://dx.doi.org/10.1016/j.nbd.2014.05.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4226742PMC
December 2014

Amyloid, neurodegeneration, and small vessel disease as predictors of dementia in the oldest-old.

Neurology 2014 Nov 10;83(20):1804-11. Epub 2014 Oct 10.

From the Departments of Neurology (O.L.L., J.T.B., B.S., M.I., E.M.), Psychiatry (O.L.L., W.E.K., J.T.B., H.J.A.), Radiology (C.M., R.L.C., J.P., A.C.), Pharmaceutical Sciences (C.M.), Psychology (J.T.B.), Biostatistics (L.W.), and Epidemiology, Graduate School of Public Health (L.H.K.), University of Pittsburgh, School of Medicine, PA; and Department of Neurology (S.T.D.), University of Virginia School of Medicine, Charlottesville.

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http://dx.doi.org/10.1212/WNL.0000000000000977DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4240431PMC
November 2014

Hyperphosphorylated tau is elevated in Alzheimer's disease with psychosis.

J Alzheimers Dis 2014 ;39(4):759-73

Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA VISN 4 Mental Illness Research, Education and Clinical Center, VA Pittsburgh Healthcare System, Pittsburgh, PA, USA Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.

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http://dx.doi.org/10.3233/JAD-131166DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4034758PMC
October 2014

Positron emission tomography radioligands for in vivo imaging of Aβ plaques.

J Labelled Comp Radiopharm 2013 Mar-Apr;56(3-4):89-95

Departments of Radiology, University of Pittsburgh, Pittsburgh, PA, 15213, USA.

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http://dx.doi.org/10.1002/jlcr.2989DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4089898PMC
July 2014

Amyloid burden and neural function in people at risk for Alzheimer's Disease.

Neurobiol Aging 2014 Mar 23;35(3):576-84. Epub 2013 Oct 23.

Geriatric Research Education and Clinical Center, Wm. S. Middleton Memorial VA Hospital, Madison, WI, USA; Alzheimer's Disease Research Center, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA; Wisconsin Alzheimer's Institute, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neurobiolaging.2013.09.028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4018215PMC
March 2014

Disclosure of amyloid imaging results to research participants: has the time come?

Alzheimers Dement 2013 Nov 13;9(6):741-744.e2. Epub 2013 Feb 13.

Health and Community Systems, University of Pittsburgh, Pittsburgh, Pennsylvania, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S15525260120252
Publisher Site
http://dx.doi.org/10.1016/j.jalz.2012.09.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3758392PMC
November 2013

Amyloid and neurodegeneration: converging and diverging paths.

Neurology 2013 Nov 16;81(20):1728-9. Epub 2013 Oct 16.

From the Departments of Psychiatry and Neurology (W.E.K.), University of Pittsburgh, PA; and the Department of Nuclear Medicine and Division of Neuroscience (D.P.), Vita-Salute San Raffaele University, San Raffaele Scientific Institute, Milan, Italy.

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http://dx.doi.org/10.1212/01.wnl.0000435568.38352.2eDOI Listing
November 2013

Pulse wave velocity is associated with β-amyloid deposition in the brains of very elderly adults.

Neurology 2013 Nov 16;81(19):1711-8. Epub 2013 Oct 16.

From the Department of Epidemiology, Graduate School of Public Health (T.M.H., L.H.K., E.J.M.B.-M., R.H.M.), and the Departments of Neurology (E.M.M., B.E.S., O.L.L.), Psychiatry (W.E.K., H.J.A., A.D.C.), and Radiology (C.A.M.), School of Medicine, University of Pittsburgh, PA; and the Office of the Dean and Department of Neurology (S.T.D.), School of Medicine, University of Virginia, Charlottesville.

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http://dx.doi.org/10.1212/01.wnl.0000435301.64776.37DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3812104PMC
November 2013

Development and screening of contrast agents for in vivo imaging of Parkinson's disease.

Mol Imaging Biol 2013 Oct;15(5):585-95

MassGeneral Institute of Neurodegenerative Disease, Massachusetts General Hospital, 114 16th Street, Charlestown, MA, 02129, USA.

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http://dx.doi.org/10.1007/s11307-013-0634-yDOI Listing
October 2013

Cognitive aging in persons with minimal amyloid-β and white matter hyperintensities.

Neuropsychologia 2013 Sep 1;51(11):2202-9. Epub 2013 Aug 1.

Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neuropsychologia.2013.07.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3807130PMC
September 2013

Imaging tau deposits in vivo: progress in viewing more of the proteopathy picture.

Neuron 2013 Sep;79(6):1035-7

Departments of Radiology, Pharmacology and Biological Chemistry, and Pharmaceutical Sciences, University of Pittsburgh, 200 Lothrop Street, Pittsburgh, PA 15213-2582, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neuron.2013.09.001DOI Listing
September 2013

Dendritic spine density, morphology, and fibrillar actin content surrounding amyloid-β plaques in a mouse model of amyloid-β deposition.

J Neuropathol Exp Neurol 2013 Aug;72(8):791-800

Translational Neuroscience Program, Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.

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http://dx.doi.org/10.1097/NEN.0b013e31829ecc89DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3763821PMC
August 2013

Using Pittsburgh Compound B for in vivo PET imaging of fibrillar amyloid-beta.

Adv Pharmacol 2012 ;64:27-81

Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.

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http://dx.doi.org/10.1016/B978-0-12-394816-8.00002-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3542972PMC
March 2013

Design, synthesis and structure-activity relationship of rhenium 2-arylbenzothiazoles as β-amyloid plaque binding agents.

Bioorg Med Chem Lett 2013 Mar 24;23(6):1720-6. Epub 2013 Jan 24.

Department of Molecular Oncology, BC Cancer Agency, Vancouver, BC, Canada V5Z1L3.

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http://dx.doi.org/10.1016/j.bmcl.2013.01.068DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3594088PMC
March 2013

Development of positron emission tomography β-amyloid plaque imaging agents.

Semin Nucl Med 2012 Nov;42(6):423-32

Department of Radiology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.

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http://dx.doi.org/10.1053/j.semnuclmed.2012.07.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3520098PMC
November 2012

Developing an international network for Alzheimer research: The Dominantly Inherited Alzheimer Network.

Clin Investig (Lond) 2012 Oct;2(10):975-984

Departments of Neurology and of Pathology and Immunology, and the Programs in Physical Therapy and Occupational Therapy, Washington University, St. Louis, MO (JCM). Other authors' affiliations are as follows: the Departments of Neurology (RB, AF, DH, VB, AO, KM, NS), Biostatistics (CX), Psychiatry (AG), Radiology (TB, DM), and Pathology and Immunology (NC), Washington University School of Medicine, St. Louis; University College London Institute of Neurology, London (MR); the Department of Neurosciences, University of California, San Diego, La Jolla (PA); the Department of Pathology and Laboratory Medicine (BG) and the Center for Bioethics (KQ), Indiana University School of Medicine, Indianapolis; the Departments of Psychiatry (WK) and Neurology (WK, EM), University of Pittsburgh School of Medicine, Pittsburgh; the Centre of Excellence for Alzheimer's Disease Research and Care, Edith Cowan University, Joondalup, WA (RM), the Mental Health Research Institute, University of Melbourne, Melbourne, VIC (CM), and Neuroscience Research Australia and the School of Medical Sciences, University of New South Wales, Sydney (PS) - all in Australia; the Taub Institute for Research on Alzheimer's Disease and the Aging Brain and the Department of Neurology, Columbia University College of Physicians and Surgeons, New York (RM); the Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles (JR); the Center for Alzheimer Research and Treatment and the Department of Neurology, Brigham and Women's Hospital, Massachusetts General Hospital, and Harvard Medical School (RS) - all in Boston; the Department of Neurology and the Memory and Aging Program, Butler Hospital, Warren Alpert Medical School of Brown University, Providence, RI (SS); and the Departments of Medicine, Radiology, and Psychiatry, University of California San Francisco (MW).

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http://dx.doi.org/10.4155/cli.12.93DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3489185PMC
October 2012

Anomalous PiB enhancement in the superior sagittal and transverse venous sinuses.

Alzheimer Dis Assoc Disord 2012 Apr-Jun;26(2):186-90

The Harvard-MIT Division of Health Sciences and Technology, Cambridge, MA, USA.

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http://dx.doi.org/10.1097/WAD.0b013e31822de18cDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3328588PMC
September 2012

Amyloid imaging in dementias with atypical presentation.

Alzheimers Dement 2012 Sep 30;8(5):389-98. Epub 2012 Jan 30.

Department of Neurology, University of Pennsylvania, Philadelphia, USA.

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http://dx.doi.org/10.1016/j.jalz.2011.07.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3517915PMC
September 2012

Brain imaging in Alzheimer disease.

Cold Spring Harb Perspect Med 2012 Apr;2(4):a006213

Departments of Radiology and Neurology, Massachusetts General Hospital, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA.

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http://perspectivesinmedicine.cshlp.org/lookup/doi/10.1101/c
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http://dx.doi.org/10.1101/cshperspect.a006213DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3312396PMC
April 2012

Mechanism of amyloid removal in patients with Alzheimer disease treated with gantenerumab.

Arch Neurol 2012 Feb 10;69(2):198-207. Epub 2011 Oct 10.

F. Hoffmann-La Roche Ltd, Neuroscience, Grenzacherstrasse 124, CH-4070 Basel, Switzerland.

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http://dx.doi.org/10.1001/archneurol.2011.1538DOI Listing
February 2012

Amyloid imaging as a biomarker for cerebral β-amyloidosis and risk prediction for Alzheimer dementia.

Authors:
William E Klunk

Neurobiol Aging 2011 Dec;32 Suppl 1:S20-36

University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.

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http://dx.doi.org/10.1016/j.neurobiolaging.2011.09.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3233688PMC
December 2011

Neuroimaging markers for the prediction and early diagnosis of Alzheimer's disease dementia.

Trends Neurosci 2011 Aug 21;34(8):430-42. Epub 2011 Jun 21.

Department of Radiology, University of California San Francisco, San Francisco, CA, USA.

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http://dx.doi.org/10.1016/j.tins.2011.05.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3275347PMC
August 2011

Inter-rater reliability of manual and automated region-of-interest delineation for PiB PET.

Neuroimage 2011 Apr 31;55(3):933-41. Epub 2010 Dec 31.

Department of Radiology, University of Pittsburgh School of Medicine, Presbyterian University Hospital, B-938, 200 Lothrop Street, Pittsburgh, PA 15213, USA.

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http://dx.doi.org/10.1016/j.neuroimage.2010.12.070DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3057323PMC
April 2011

Progression of cerebral amyloid load is associated with the apolipoprotein E ε4 genotype in Alzheimer's disease.

Biol Psychiatry 2010 Nov 2;68(10):879-84. Epub 2010 Jul 2.

Department of Psychiatry and Psychotherapy, Klinikum rechts der Isar der Technischen Universität München, Munich, Federal Republic of Germany.

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http://dx.doi.org/10.1016/j.biopsych.2010.05.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3045041PMC
November 2010