William E Farrell

William E Farrell

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William E Farrell

William E Farrell

Publications by authors named "William E Farrell"

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Maternal genome-wide DNA methylation profiling in gestational diabetes shows distinctive disease-associated changes relative to matched healthy pregnancies.

Epigenetics 2018 25;13(2):122-128. Epub 2018 Jan 25.

a Institute for Science and Technology in Medicine , Keele University, Guy Hilton Research Center , Staffordshire , UK.

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http://dx.doi.org/10.1080/15592294.2016.1166321DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5873366PMC
December 2018

DNA methylation at diagnosis is associated with response to disease-modifying drugs in early rheumatoid arthritis.

Epigenomics 2017 04 25;9(4):419-428. Epub 2016 Nov 25.

Guy Hilton Research Centre, Institute for Applied Clinical Sciences, Keele University, Thornburrow Drive, Hartshill, Stoke-on-Trent, Staffordshire, ST4 7QB, UK.

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http://dx.doi.org/10.2217/epi-2016-0042DOI Listing
April 2017

The BH3 Mimetic Obatoclax Accumulates in Lysosomes and Causes Their Alkalinization.

PLoS One 2016 7;11(3):e0150696. Epub 2016 Mar 7.

Institute for Science and Technology in Medicine, Keele University, Stoke-on-Trent, Staffordshire, United Kingdom.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0150696PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4780728PMC
August 2016

DNA methylation profiling of synovial fluid FLS in rheumatoid arthritis reveals changes common with tissue-derived FLS.

Epigenomics 2015 ;7(4):539-51

Institute for Science & Technology in Medicine, Keele University, Guy Hilton Research Centre, Thornburrow Drive, Hartshill, Stoke-on-Trent, Staffordshire, ST4 7QB, UK.

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http://dx.doi.org/10.2217/epi.15.15DOI Listing
June 2016

Genome-wide profiling in treatment-naive early rheumatoid arthritis reveals DNA methylome changes in T and B lymphocytes.

Epigenomics 2016 Feb 10;8(2):209-24. Epub 2015 Nov 10.

Institute for Science & Technology in Medicine, Keele University, Guy Hilton Research Centre, Thornburrow Drive, Hartshill, Stoke-on-Trent, Staffordshire, ST4 7QB, UK.

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http://dx.doi.org/10.2217/epi.15.103DOI Listing
February 2016

Epidrug mediated re-expression of miRNA targeting the HMGA transcripts in pituitary cells.

Pituitary 2015 Oct;18(5):674-84

Human Disease and Genomics Group, Institute of Science and Technology in Medicine, School of Medicine, Keele University, Stoke-on-Trent, Staffordshire, ST4 7QB, UK.

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http://dx.doi.org/10.1007/s11102-014-0630-5DOI Listing
October 2015

Methylation of the FGFR2 gene is associated with high birth weight centile in humans.

Epigenomics 2014 ;6(5):477-91

Institute of Science & Technology in Medicine, Keele University School of Medicine, University Hospital of North Staffordshire, Stoke-on-Trent, Staffordshire, UK.

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http://dx.doi.org/10.2217/epi.14.40DOI Listing
July 2015

The EFEMP1 gene: a frequent target for epigenetic silencing in multiple human pituitary adenoma subtypes.

Neuroendocrinology 2013 6;98(3):200-11. Epub 2013 Nov 6.

Institute of Science and Technology in Medicine, Keele University School of Medicine, Stoke-on-Trent, UK.

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http://dx.doi.org/10.1159/000355624DOI Listing
August 2014

Epigenetics of pituitary tumours: an update.

Curr Opin Endocrinol Diabetes Obes 2014 Aug;21(4):299-305

Human Disease and Genomics Group, Institute of Science and Technology in Medicine, School of Medicine, Keele University, Stoke on Trent, Staffordshire, UK.

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http://dx.doi.org/10.1097/MED.0000000000000078DOI Listing
August 2014

Epigenome-wide profiling identifies significant differences in DNA methylation between matched-pairs of T- and B-lymphocytes from healthy individuals.

Epigenetics 2013 Nov 4;8(11):1188-97. Epub 2013 Sep 4.

Institute for Science and Technology in Medicine; Keele University; Guy Hilton Research Centre; Staffordshire, UK.

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http://dx.doi.org/10.4161/epi.26265DOI Listing
November 2013

Preincubation of pituitary tumor cells with the epidrugs zebularine and trichostatin A are permissive for retinoic acid-augmented expression of the BMP-4 and D2R genes.

Endocrinology 2013 May 28;154(5):1711-21. Epub 2013 Mar 28.

Institute of Science and Technology in Medicine, Keele University School of Medicine, Stoke-on-Trent ST4 7QB, United Kingdom.

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http://dx.doi.org/10.1210/en.2013-1061DOI Listing
May 2013

Combined influence of gene-specific cord blood methylation and maternal smoking habit on birth weight.

Epigenomics 2013 Feb;5(1):37-49

Institute of Science & Technology in Medicine, Keele University School of Medicine, Stoke-on-Trent, Staffordshire, UK.

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http://dx.doi.org/10.2217/epi.12.72DOI Listing
February 2013

Antiepileptic drugs and the fetal epigenome.

Epilepsia 2013 Jan 27;54(1):e16-9. Epub 2012 Sep 27.

School of Veterinary Medicine and Science, University of Nottingham, Sutton Bonington, Leicestershire, United Kingdom.

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http://dx.doi.org/10.1111/j.1528-1167.2012.03673.xDOI Listing
January 2013

Quantitative, genome-wide analysis of the DNA methylome in sporadic pituitary adenomas.

Endocr Relat Cancer 2012 Dec 19;19(6):805-16. Epub 2012 Nov 19.

Institute of Science and Technology in Medicine, Keele University School of Medicine, Stoke-on-Trent, Staffordshire ST4 7QB, UK.

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http://dx.doi.org/10.1530/ERC-12-0251DOI Listing
December 2012

Make way for the 'next generation': application and prospects for genome-wide, epigenome-specific technologies in endocrine research.

J Mol Endocrinol 2012 Aug 29;49(1):R19-27. Epub 2012 May 29.

School of Veterinary Medicine and Science, University of Nottingham, Sutton Bonington Campus, College Road, Leicestershire LE12 5RD, UK.

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http://dx.doi.org/10.1530/JME-12-0045DOI Listing
August 2012

Epigenomic silencing of the BMP-4 gene in pituitary adenomas: a potential target for epidrug-induced re-expression.

Endocrinology 2012 Aug 14;153(8):3603-12. Epub 2012 Jun 14.

Human Disease and Genomics Group, Institute of Science and Technology in Medicine, School of Medicine, Keele University, Stoke on Trent, Staffordshire ST4 7QB, United Kingdom.

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http://dx.doi.org/10.1210/en.2012-1231DOI Listing
August 2012

The pituitary tumour epigenome: aberrations and prospects for targeted therapy.

Nat Rev Endocrinol 2012 Apr 24;8(8):486-94. Epub 2012 Apr 24.

Human Disease and Genomics Group, Institute of Science and Technology in Medicine, School of Medicine, Keele University, Stoke-on-Trent, Staffordshire ST4 7QB, UK.

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http://dx.doi.org/10.1038/nrendo.2012.54DOI Listing
April 2012

Unique gene expression profile associated with an early-onset multiple endocrine neoplasia (MEN1)-associated pituitary adenoma.

J Clin Endocrinol Metab 2011 Nov 14;96(11):E1905-14. Epub 2011 Sep 14.

Section on Endocrinology and Genetics, Program on Developmental Endocrinology and Genetics, Eunice Kennedy Shriver National Institute of Child Health & Human Development, National Institutes of Health, Building 10, CRC, Room 1-3330, 10 Center Drive, MSC1103, Bethesda, Maryland 20892, USA.

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https://academic.oup.com/jcem/article-lookup/doi/10.1210/jc.
Publisher Site
http://dx.doi.org/10.1210/jc.2011-1127DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3205896PMC
November 2011

Reversal of endogenous dopamine receptor silencing in pituitary cells augments receptor-mediated apoptosis.

Endocrinology 2011 Feb 22;152(2):364-73. Epub 2010 Dec 22.

Human Disease and Genomics Group, Institute of Science and Technology in Medicine, School of Medicine, Keele University, Stoke on Trent, Staffordshire ST4 7QB United Kingdom.

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https://academic.oup.com/endo/article-lookup/doi/10.1210/en.
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http://dx.doi.org/10.1210/en.2010-0886DOI Listing
February 2011

Quantitative, high-resolution epigenetic profiling of CpG loci identifies associations with cord blood plasma homocysteine and birth weight in humans.

Epigenetics 2011 Jan 1;6(1):86-94. Epub 2011 Jan 1.

Institute of Science and Technology in Medicine, Keele University School of Medicine, University Hospital of North Staffordshire; Stoke-on-Trent, Staffordshire, UK.

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http://dx.doi.org/10.4161/epi.6.1.13392DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3052917PMC
January 2011

Studies of pituitary tumors.

Mol Cell Endocrinol 2010 Sep 13;326(1-2):1-2. Epub 2010 May 13.

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http://dx.doi.org/10.1016/j.mce.2010.05.002DOI Listing
September 2010

LINE-1 DNA methylation is inversely correlated with cord plasma homocysteine in man: a preliminary study.

Epigenetics 2009 Aug 18;4(6):394-8. Epub 2009 Aug 18.

Institute of Science and Technology in Medicine, Keele University Medical School, University Hospital of North Staffordshire, Stoke-on-Trent, Staffordshire, UK.

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http://dx.doi.org/10.4161/epi.4.6.9766DOI Listing
August 2009

Genome-wide analysis in a murine Dnmt1 knockdown model identifies epigenetically silenced genes in primary human pituitary tumors.

Mol Cancer Res 2008 Oct;6(10):1567-74

Institute of Science and Technology in Medicine, Keele University, Hartshill, Stoke on Trent, United Kingdom.

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http://dx.doi.org/10.1158/1541-7786.MCR-08-0234DOI Listing
October 2008

Primary colorectal tumors fail to express the proapoptotic mediator PTAG and its reexpression augments drug-induced apoptosis.

Genes Chromosomes Cancer 2007 Feb;46(2):202-12

Institute of Science and Technology in Medicine, School of Medicine, Keele University, Stoke on Trent, Staffordshire ST4 7QB, UK.

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http://dx.doi.org/10.1002/gcc.20401DOI Listing
February 2007

Corticotroph carcinoma presenting as a silent corticotroph adenoma.

Pituitary 2003 ;6(1):41-7

School of Postgraduate Medicine, North Staffs Hospital, Stoke on Trent, UK.

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http://dx.doi.org/10.1023/a:1026233927714DOI Listing
July 2004

Isolation and characterization of a novel pituitary tumor apoptosis gene.

Mol Endocrinol 2004 Jul 22;18(7):1827-39. Epub 2004 Apr 22.

Institute for Science and Technology in Medicine, Medical Research Unit, School of Postgraduate Medicine, Keele University, North Staffordshire Hospital, Stoke-on-Trent ST4 7QB, United Kingdom.

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http://dx.doi.org/10.1210/me.2004-0087DOI Listing
July 2004

Molecular pathology shows p16 methylation in nonadenomatous pituitaries from patients with Cushing's disease.

Clin Cancer Res 2004 Mar;10(5):1780-8

Institute of Science and Technology in Medicine, School of Medicine, Keele University, Stoke on Trent, Staffordshire, United Kingdom.

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http://dx.doi.org/10.1158/1078-0432.ccr-1127-3DOI Listing
March 2004

Loss of expression of the growth inhibitory gene GADD45gamma, in human pituitary adenomas, is associated with CpG island methylation.

Oncogene 2004 Jan;23(4):936-44

School of Medicine, Keele University, North Staffordshire Hospital, Stoke-on-Trent, Staffordshire ST4 7QB, UK.

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http://dx.doi.org/10.1038/sj.onc.1207193DOI Listing
January 2004

Expression of phosphorylated p27(Kip1) protein and Jun activation domain-binding protein 1 in human pituitary tumors.

J Clin Endocrinol Metab 2002 Jun;87(6):2635-43

Department of Endocrinology, St. Bartholomew's Hospital, West Smithfield, London EC1A 7BE, United Kingdom.

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http://dx.doi.org/10.1210/jcem.87.6.8517DOI Listing
June 2002

Loss of heterozygosity on chromosome 10q is associated with earlier onset sporadic colorectal adenocarcinoma.

Int J Cancer 2002 Jun;99(6):829-33

Centre for Cell and Molecular Medicine, School of Postgraduate Medicine, Keele University, North Staffordshire Hospital, Stoke-on-Trent, United Kingdom.

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http://dx.doi.org/10.1002/ijc.10432DOI Listing
June 2002