William E Evans

William E Evans

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William E Evans

William E Evans

Publications by authors named "William E Evans"

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ARID5B influences anti-metabolite drug sensitivity and prognosis of acute lymphoblastic leukemia.

Clin Cancer Res 2019 Oct 1. Epub 2019 Oct 1.

Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital

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http://dx.doi.org/10.1158/1078-0432.CCR-19-0190DOI Listing
October 2019

The Promise and the Reality of Genomics to Guide Precision Medicine in Pediatric Oncology: The Decade Ahead.

Clin Pharmacol Ther 2019 Sep 28. Epub 2019 Sep 28.

Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, TN, USA.

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http://dx.doi.org/10.1002/cpt.1660DOI Listing
September 2019

Genome-wide CRISPR screen reveals PSMA6 to be an essential gene in pancreatic cancer cells.

BMC Cancer 2019 Mar 21;19(1):253. Epub 2019 Mar 21.

Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, TN, USA.

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http://dx.doi.org/10.1186/s12885-019-5455-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6429770PMC
March 2019

Pharmacogenomics of Vincristine-Induced Peripheral Neuropathy: Progress Continues.

Clin Pharmacol Ther 2019 Feb 16;105(2):315-317. Epub 2018 Sep 16.

Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.

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http://dx.doi.org/10.1002/cpt.1209DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6355340PMC
February 2019

Peripheral neuropathy in children and adolescents treated for cancer.

Lancet Child Adolesc Health 2018 10 1;2(10):744-754. Epub 2018 Sep 1.

Epidemiology and Cancer Control, St Jude Children's Research Hospital, Memphis, TN, USA. Electronic address:

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http://dx.doi.org/10.1016/S2352-4642(18)30236-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6287277PMC
October 2018

TP53 Germline Variations Influence the Predisposition and Prognosis of B-Cell Acute Lymphoblastic Leukemia in Children.

J Clin Oncol 2018 02 4;36(6):591-599. Epub 2018 Jan 4.

Maoxiang Qian, Xueyuan Cao, Wenjian Yang, Cheng Cheng, Hui Zhang, Takaya Moriyama, Gerard Zambetti, Kim E. Nichols, Ching-Hon Pui, Charles G. Mullighan, William E. Evans, Mary V. Relling, and Jun J. Yang, St Jude Children's Research Hospital, Memphis, TN; Meenakshi Devidas and Yunfeng Dai, University of Florida, Gainesville, FL; Andrew Carroll, University of Alabama at Birmingham, Birmingham, AL; Nyla A. Heerema and Julie M. Gastier-Foster, The Ohio State University and Wexner Medical Center; Julie M. Gastier-Foster and Elaine R. Mardis, Nationwide Children's Hospital, Columbus, OH; Hui Zhang, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong; Heng Xu, West China Hospital, Sichuan University and Collaborative Innovation Center, Chengdu, China; Elizabeth Raetz, University of Utah, Salt Lake City, UT; Eric Larsen, Maine Children's Cancer Program, Scarborough, ME; Naomi Winick, University of Texas Southwestern Medical Center, Dallas; W. Paul Bowman, Cook Children's Medical Center, Fort Worth, TX; Paul L. Martin, Duke University, Durham, NC; Robert Fulton, Washington University School of Medicine, St Louis, MO; Michael Borowitz, Johns Hopkins Medical Institute, Baltimore, MD; Brent Wood, University of Washington, Seattle, WA; William L. Carroll, New York University, New York, NY; Stephen P. Hunger, Children's Hospital of Philadelphia and University of Pennsylvania, Philadelphia, PA; and Mignon L. Loh, Benioff Children's Hospital and University of California, San Francisco, San Francisco, CA.

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http://dx.doi.org/10.1200/JCO.2017.75.5215DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5815403PMC
February 2018

Differential effects of thiopurine methyltransferase (TPMT) and multidrug resistance-associated protein gene 4 (MRP4) on mercaptopurine toxicity.

Cancer Chemother Pharmacol 2017 Aug 16;80(2):287-293. Epub 2017 Jun 16.

Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN, 38105-2794, USA.

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http://dx.doi.org/10.1007/s00280-017-3361-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5628515PMC
August 2017

Genetics of pleiotropic effects of dexamethasone.

Pharmacogenet Genomics 2017 08;27(8):294-302

Departments of aPharmaceutical Sciences bBiostatistics cOncology dComprehensive Cancer Center, St Jude Children's Research Hospital, Memphis, Tennessee, USA.

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http://dx.doi.org/10.1097/FPC.0000000000000293DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5523978PMC
August 2017

Mercaptopurine Ingestion Habits, Red Cell Thioguanine Nucleotide Levels, and Relapse Risk in Children With Acute Lymphoblastic Leukemia: A Report From the Children's Oncology Group Study AALL03N1.

J Clin Oncol 2017 May 24;35(15):1730-1736. Epub 2017 Mar 24.

Wendy Landier, Lindsey Hageman, Yanjun Chen, and Smita Bhatia, University of Alabama at Birmingham, Birmingham, AL; Nancy Kornegay, William E. Evans, and Mary V. Relling, St. Jude Children's Research Hospital, Memphis, TN; Bruce C. Bostrom, Children's Hospitals and Clinics of Minnesota, Minneapolis, MN; Jacqueline Casillas, David Geffen School of Medicine at University of California Los Angeles, Los Angeles; Leo Mascarenhas and Amanda M. Termuhlen, Children's Hospital Los Angeles, Los Angeles; F. Lennie Wong, City of Hope, Duarte, CA; David S. Dickens, Helen DeVos Children's Hospital at Spectrum Health/Spectrum Health at Butterworth Campus, Grand Rapids, MI; Anne L. Angiolillo, The George Washington School of Medicine, Washington, DC; Glen Lew, Children's Healthcare of Atlanta, Emory University, Atlanta, GA; Kelly W. Maloney, University of Colorado School of Medicine, Aurora, CO; A. Kim Ritchey, Children's Hospital of Pittsburgh of University of Pittsburgh Medical Center, Pittsburgh, PA; and William L. Carroll, Perlmutter Cancer Center, New York University-Langone Medical Center, New York, NY.

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http://dx.doi.org/10.1200/JCO.2016.71.7579DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5455766PMC
May 2017

Msh2 deficiency leads to dysmyelination of the corpus callosum, impaired locomotion, and altered sensory function in mice.

Sci Rep 2016 08 1;6:30757. Epub 2016 Aug 1.

Hematological Malignancies Program and Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, 38105, USA.

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http://dx.doi.org/10.1038/srep30757DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4967871PMC
August 2016

Clinical and Genetic Risk Factors for Acute Pancreatitis in Patients With Acute Lymphoblastic Leukemia.

J Clin Oncol 2016 06 25;34(18):2133-40. Epub 2016 Apr 25.

Chengcheng Liu, Wenjian Yang, Cheng Cheng, Deqing Pei, Colton Smith, Sima Jeha, Ching-Hon Pui, William E. Evans, and Mary V. Relling, St Jude Children's Research Hospital; Scott C. Howard, University of Memphis, Memphis, TN; Meenakshi Devidas, University of Florida, Gainesville, FL; William L. Carroll, New York University Langone Medical Center, New York, NY; Elizabeth A. Raetz, University of Utah, Salt Lake City, UT; W. Paul Bowman, Cook Children's Hospital, Ft Worth; Naomi J. Winick, University of Texas Southwestern Medical Center, Dallas, TX; Eric C. Larsen, Maine Children's Cancer Program, Scarborough, ME; Kelly W. Maloney, University of Colorado Denver, Aurora, CO; Paul L. Martin, Duke University, Durham, NC; Leonard A. Mattano Jr, HARP Pharma Consulting, Mystic, CT; Elaine R. Mardis and Robert S. Fulton, The McDonnell Genome Institute, Washington University School of Medicine, St. Louis, MO; Deepa Bhojwani, Children's Hospital of Los Angeles, Los Angeles; Mignon L. Loh, University of California San Francisco Medical Center-Parnassus, San Francisco, CA; and Stephen P. Hunger, Children's Hospital of Philadelphia, Philadelphia, PA.

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http://dx.doi.org/10.1200/JCO.2015.64.5812DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4962704PMC
June 2016

Vincristine pharmacogenomics: 'winner's curse' or a different phenotype?

Pharmacogenet Genomics 2016 Feb;26(2):51-2

St. Jude Children's Research Hospital, Memphis, Tennessee, USA.

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http://dx.doi.org/10.1097/FPC.0000000000000192DOI Listing
February 2016

Inflammasome-mediated glucocorticoid resistance: The receptor rheostat.

Mol Cell Oncol 2016 Jan 11;3(1):e1065947. Epub 2015 Nov 11.

Hematological Malignancies Program, and Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital , Memphis, TN, USA.

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http://dx.doi.org/10.1080/23723556.2015.1065947DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4845245PMC
January 2016

Pharmacogenomics in the clinic.

Nature 2015 Oct;526(7573):343-50

Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, Tennessee 38105-2794, USA.

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http://dx.doi.org/10.1038/nature15817DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4711261PMC
October 2015

BCR-ABL1-like cases in pediatric acute lymphoblastic leukemia: a comparison between DCOG/Erasmus MC and COG/St. Jude signatures.

Haematologica 2015 Sep 4;100(9):e354-7. Epub 2015 Jun 4.

Department of Pediatric Oncology/Hematology, Erasmus MC -Sophia Children's Hospital, Rotterdam, The Netherlands Dutch Childhood Oncology Group, The Hague, The Netherlands

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http://dx.doi.org/10.3324/haematol.2015.124941DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4800707PMC
September 2015

Childhood Acute Lymphoblastic Leukemia: Progress Through Collaboration.

J Clin Oncol 2015 Sep 24;33(27):2938-48. Epub 2015 Aug 24.

Ching-Hon Pui, Jun J. Yang, James R. Downing, Williams E. Evans, Mary V. Relling, and Charles G. Mullighan, St Jude Children's Research Hospital and the University of Tennessee Health Science Center, Memphis, TN; Stephen P. Hunger, University of Colorado School of Medicine and the University of Colorado Cancer Center and Children's Hospital Colorado, Aurora, CO; Rob Pieters, Princess Máxima Center for Pediatric Oncology, Utrecht, the Netherlands; Martin Schrappe, University Medical Center Schleswig-Holstein, Christian-Albrechts-University, Kiel; Gabriele Escherich, Clinic of Pediatric Hematology and Oncology, University Medical Center Hamburg Eppendorf, Hamburg, Germany; Andrea Biondi, Clinica Pediatrica and Centro Ricerca Tettamanti, Università di Milano-Bicocca, Monza, Italy; Ajay Vora, Children's Cancer Group, School of Cancer, Manchester Academic Health Sciences Centre, University of Manchester, Manchester, United Kingdom; André Baruchel, Hôpital Robert Debré and University of Paris Diderot, Paris, France; Lewis B. Silverman, Dana-Farber Cancer Institute and Boston Children's Hospital, Boston, MA; Kjeld Schmiegelow, Institute of Clinical Medicine, University of Copenhagen and Juliane Marie Centre, the University Hospital Rigshospitalet, Copenhagen, Denmark; Keizo Horibe, Nagoya Medical Center, Clinical Research Center, Nagoya, Japan; Yves C.M. Benoit, Universiteit Gent, Gent, Belgium; Shai Izraeli, Chaim Sheba Medical Center and Sackler Medical School, Tel Aviv University, Tel Aviv, Israel; Allen Eng Juh Yeoh, Yong Loo Lin School of Medicine and Cancer Science Institute, National University of Singapore, and Viva-University Children's Cancer Centre, National University Hospital, Singapore; and Der-Cherng Liang, Mackay Memorial Hospital, Taipei, Taiwan.

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http://jco.ascopubs.org/content/early/2015/08/21/JCO.2014.59
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http://200.40.135.66:90/toc/0873/2015/0873-20150920-27-01.pd
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http://jco.ascopubs.org/cgi/doi/10.1200/JCO.2014.59.1636
Publisher Site
http://dx.doi.org/10.1200/JCO.2014.59.1636DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4567699PMC
September 2015

Inherited NUDT15 variant is a genetic determinant of mercaptopurine intolerance in children with acute lymphoblastic leukemia.

J Clin Oncol 2015 Apr 26;33(11):1235-42. Epub 2015 Jan 26.

Jun J. Yang, Wenjian Yang, Chengcheng Liu, Cheng Cheng, Deqing Pei, Kristine R. Crews, Nancy Kornegay, William E. Evans, Ching-Hon Pui, and Mary V. Relling, St Jude Children's Research Hospital, Memphis, TN; and Wendy Landier, Lindsey Hageman, Yanjun Chen, F. Lennie Wong, and Smita Bhatia, City of Hope, Duarte, CA.

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http://jco.ascopubs.org/content/33/11/1235.full.pdf
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http://jco.ascopubs.org/cgi/doi/10.1200/JCO.2014.59.4671
Publisher Site
http://dx.doi.org/10.1200/JCO.2014.59.4671DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4375304PMC
April 2015

Effect of premedications in a murine model of asparaginase hypersensitivity.

J Pharmacol Exp Ther 2015 Mar 8;352(3):541-51. Epub 2015 Jan 8.

Department of Pharmaceutical Sciences (C.A.F., C.S., S.E.K., L.B.R., C.L., W.E.E., M.V.R.) and Department of Oncology (S.E.K., C.-H.P., S.J.), St. Jude Children's Research Hospital, Memphis, Tennessee; Department of Medicine, Cincinnati Veterans Affairs Medical Center, Cincinnati, Ohio (F.D.F.); Department of Internal Medicine, Division of Immunology, Allergy and Rheumatology, University of Cincinnati College of Medicine, Cincinnati, Ohio (F.D.F.); and Division of Immunobiology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio (F.D.F.)

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http://dx.doi.org/10.1124/jpet.114.220780DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4352598PMC
March 2015

Targetable kinase-activating lesions in Ph-like acute lymphoblastic leukemia.

N Engl J Med 2014 Sep;371(11):1005-15

From the Departments of Pathology (K.G.R., D.P.-T., Y.-L.Y., K. McCastlain, G.S., J.M., S.-C.C., J.C., N.S.-M., I.I., J.W., J.R.D., C.G.M.), Computational Biology and Bioinformatics (Y.L., J.B., M.R., E.H., P.G., P.N., G.W., X.C., J.Z.), Biostatistics (D.P., C.C.), Pharmaceutical Sciences (S.W.P., M.V.R., W.E.E.), and Oncology (C.-H.P., S.J.), the Pediatric Cancer Genome Project (Y.L., L.D., C.L., M.R., J.E., J.C., K.B., R.S.F., E.H., P.G., P.N., G.W., X.C., D.Y., B.V., H.M., M.V.R., W.E.E., E.M., R.K.W., J.R.D., J.Z., C.G.M.), and Cytogenetics Shared Resource (M.V.), St. Jude Children's Research Hospital, Memphis, TN; the University of New Mexico Cancer Center and School of Medicine, Albuquerque (R.C.H., I-M.C., C.L.W.); the Genome Institute at Washington University (L.D., C.L., R.S.F., E.M., R.K.W.), the Department of Genetics, Washington University School of Medicine (L.D., C.L., R.S.F., E.M., R.K.W.), and Siteman Cancer Center, Washington University (E.M., R.K.W.) - all in St. Louis; Epidemiology and Health Policy Research, College of Medicine, University of Florida, Gainesville (M.D.); the Research Institute at Nationwide Children's Hospital (S.R., A.S., J.M.G.-F.), the Department of Pathology, College of Medicine, Ohio State University (N.A.H.), and Ohio State University Comprehensive Cancer Center (G.M., C.D.B., K. Mrózek, J.K.) - all in Columbus, OH; the Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas (N.J.W.), Scott and White Hospitals and Clinics and Texas A&M Health Science Center, Temple (G.G.), the University of Texas Health Science Center San Antonio, San Antonio (M.F.-J.), and the Departments of Leukemia and Stem Cell Transplantation, Division of Cancer Medicine, University of Texas M.D. Anderson Cancer Center, Houston (S.M.K., M.K.) - all in Texas; Maine Children's Cancer Program, Scarborough (E.C.L.); New York University Cancer Institute, New York (W.L.C.), and the Department of Medicine (Oncology), Albert Einstein

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http://dx.doi.org/10.1056/NEJMoa1403088DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4191900PMC
September 2014

Host thiopurine methyltransferase status affects mercaptopurine antileukemic effectiveness in a murine model.

Pharmacogenet Genomics 2014 May;24(5):263-71

Departments of aPharmaceutical Sciences bPathology cBiostatistics dOncology, St Jude Children's Research Hospital (Current address Puma Biotechnology Inc., Los Angeles, CA 90024, USA) eDepartment of Tumor Cell Biology, Howard Hughes Medical Institute, St Jude Children's Research Hospital, Memphis, Tennessee, USA.

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http://dx.doi.org/10.1097/FPC.0000000000000044DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4019208PMC
May 2014

Mathematical modeling of folate metabolism.

Wiley Interdiscip Rev Syst Biol Med 2013 Sep-Oct;5(5):603-13. Epub 2013 May 22.

Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, TN, USA.

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http://dx.doi.org/10.1002/wsbm.1227DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3745816PMC
March 2014

Methotrexate-induced neurotoxicity and leukoencephalopathy in childhood acute lymphoblastic leukemia.

J Clin Oncol 2014 Mar 18;32(9):949-59. Epub 2014 Feb 18.

All authors: St Jude Children's Research Hospital; and Deepa Bhojwani, Jun J. Yang, Hiroto Inaba, Jeffrey E. Rubnitz, Monika L. Metzger, Scott C. Howard, Raul C. Ribeiro, Sima Jeha, John T. Sandlund, and Ching-Hon Pui, University of Tennessee Health Sciences Center, College of Medicine, Memphis, TN.

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http://dx.doi.org/10.1200/JCO.2013.53.0808DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3948096PMC
March 2014

The Pharmacogenomics Research Network Translational Pharmacogenetics Program: overcoming challenges of real-world implementation.

Clin Pharmacol Ther 2013 Aug 19;94(2):207-10. Epub 2013 Mar 19.

Program in Personalized and Genomic Medicine and Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland, USA.

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http://dx.doi.org/10.1038/clpt.2013.59DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3720847PMC
August 2013

Between-course targeting of methotrexate exposure using pharmacokinetically guided dosage adjustments.

Cancer Chemother Pharmacol 2013 Aug 13;72(2):369-78. Epub 2013 Jun 13.

Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105-3678, USA.

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http://dx.doi.org/10.1007/s00280-013-2206-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3719000PMC
August 2013

A 50-year journey to cure childhood acute lymphoblastic leukemia.

Semin Hematol 2013 Jul;50(3):185-96

Departments of Oncology and Pharmaceutical Sciences, St. Jude Children's Research Hospital.

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http://dx.doi.org/10.1053/j.seminhematol.2013.06.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3771494PMC
July 2013

Culture trumps strategy: we must encourage the next generation of pharmacists to keep looking over the horizon and not be limited by what they can see today.

Authors:
William E Evans

J Am Pharm Assoc (2003) 2012 Jul-Aug;52(4):450-3

St. Jude Children's Research Hospital, USA.

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http://dx.doi.org/10.1331/JAPhA.2012.12522DOI Listing
December 2012

Pediatric acute lymphoblastic leukemia: where are we going and how do we get there?

Blood 2012 Aug 22;120(6):1165-74. Epub 2012 Jun 22.

Department of Oncology, St Jude Children's Research Hospital, Memphis, TN, USA.

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http://dx.doi.org/10.1182/blood-2012-05-378943DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3418713PMC
August 2012

The Pediatric Cancer Genome Project.

Nat Genet 2012 May 29;44(6):619-22. Epub 2012 May 29.

St. Jude Children's Research Hospital-Washington University Pediatric Cancer Genome Project, Memphis, Tennessee, USA.

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http://dx.doi.org/10.1038/ng.2287DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3619412PMC
May 2012

Pharmacogenomics in pediatric leukemia.

Curr Opin Pediatr 2010 Dec;22(6):703-10

Hematological Malignancies Program and Department of Pharmaceutical Sciences, St Jude Children's Research Hospital, Memphis, Tennessee 38105, USA.

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http://dx.doi.org/10.1097/MOP.0b013e32833fde85DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3612020PMC
December 2010

Modeling mechanisms of in vivo variability in methotrexate accumulation and folate pathway inhibition in acute lymphoblastic leukemia cells.

PLoS Comput Biol 2010 Dec 2;6(12):e1001019. Epub 2010 Dec 2.

Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, Tennessee, United States of America.

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http://dx.doi.org/10.1371/journal.pcbi.1001019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2996318PMC
December 2010

Genetic polymorphism of inosine-triphosphate-pyrophosphatase influences mercaptopurine metabolism and toxicity during treatment of acute lymphoblastic leukemia individualized for thiopurine-S-methyl-transferase status.

Expert Opin Drug Saf 2010 Jan;9(1):23-37

St. Jude Children's Research Hospital, Department of Pharmaceutical Sciences, 262 Danny Thomas Place MS 272, Memphis, TN 38105, USA.

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http://dx.doi.org/10.1517/14740330903426151DOI Listing
January 2010

Pharmacogenetics in acute lymphoblastic leukemia.

Semin Hematol 2009 Jan;46(1):39-51

Jean-Pierre Aubert Research Center, INSERM U837, Genomics Core IRCL-IMPRT, Lille, France.

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http://dx.doi.org/10.1053/j.seminhematol.2008.09.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2665795PMC
January 2009