William Dougall

Department of Urology, University Medicine at the Ernst-Moritz-Arndt University Greifswald, Greifswald, Germany; Institute of Urologic Oncology, Department of Urology, David Geffen School of Medicine at the University of California, Los Angeles, CA; Institute of Medical Biochemistry and Molecular Medicine, University Medicine at the Ernst-Moritz-Arndt University Greifswald, Greifswald, Germany. Electronic address:

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November 2018

TIGIT immune checkpoint blockade restores CD8 T-cell immunity against multiple myeloma.

Authors:

Camille Guillerey Heidi Harjunpää Nadège Carrié Sahar Kassem Tricia Teo Kim Miles Sophie Krumeich Marianne Weulersse Marine Cuisinier Kimberley Stannard Yuan Yu Simone A Minnie Geoffrey R Hill William C Dougall Hervé Avet-Loiseau Michele W L Teng Kyohei Nakamura Ludovic Martinet Mark J Smyth

Blood 2018 10 9;132(16):1689-1694. Epub 2018 Jul 9.

Immunology in Cancer and Infection Laboratory, QIMR Berghofer Medical Research Institute.

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October 2018

Deficiency of host CD96 and PD-1 or TIGIT enhances tumor immunity without significantly compromising immune homeostasis.

Authors:

Heidi Harjunpää Stephen J Blake Elizabeth Ahern Stacey Allen Jing Liu Juming Yan Viviana Lutzky Kazuyoshi Takeda Amy Roman Aguilera Camille Guillerey Deepak Mittal Xian Yang Li William C Dougall Mark J Smyth Michele W L Teng

Oncoimmunology 2018;7(7):e1445949. Epub 2018 Mar 26.

Cancer Immunoregulation and Immunotherapy Laboratory, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia.

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March 2018

RANKL blockade improves efficacy of PD1-PD-L1 blockade or dual PD1-PD-L1 and CTLA4 blockade in mouse models of cancer.

Authors:

Elizabeth Ahern Heidi Harjunpää Jake S O'Donnell Stacey Allen William C Dougall Michele W L Teng Mark J Smyth

Oncoimmunology 2018;7(6):e1431088. Epub 2018 Feb 14.

Department of Immunology, Immunology in Cancer and Infection Laboratory, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia.

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February 2018

CD155 loss enhances tumor suppression via combined host and tumor-intrinsic mechanisms.

Authors:

Xian-Yang Li Indrajit Das Ailin Lepletier Venkateswar Addala Tobias Bald Kimberley Stannard Deborah Barkauskas Jing Liu Amelia Roman Aguilera Kazuyoshi Takeda Matthias Braun Kyohei Nakamura Sebastien Jacquelin Steven W Lane Michele Wl Teng William C Dougall Mark J Smyth

J Clin Invest 2018 06 14;128(6):2613-2625. Epub 2018 May 14.

Immunology in Cancer and Infection Laboratory and.

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June 2018

CD96 targeted antibodies need not block CD96-CD155 interactions to promote NK cell anti-metastatic activity.

Authors:

Amelia Roman Aguilera Viviana P Lutzky Deepak Mittal Xian-Yang Li Kimberley Stannard Kazuyoshi Takeda Günter Bernhardt Michele W L Teng William C Dougall Mark J Smyth

Oncoimmunology 2018;7(5):e1424677. Epub 2018 Feb 1.

Immunology in Cancer and Infection Laboratory, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia.

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February 2018

RANK rewires energy homeostasis in lung cancer cells and drives primary lung cancer.

Genes Dev 2017 10 8;31(20):2099-2112. Epub 2017 Nov 8.

Institute of Molecular Biotechnology of the Austrian Academy of Sciences (IMBA), Vienna 1030, Austria.

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October 2017

Co-administration of RANKL and CTLA4 Antibodies Enhances Lymphocyte-Mediated Antitumor Immunity in Mice.

Authors:

Elizabeth Ahern Heidi Harjunpää Deborah Barkauskas Stacey Allen Kazuyoshi Takeda Hideo Yagita David Wyld William C Dougall Michele W L Teng Mark J Smyth

Clin Cancer Res 2017 Oct 20;23(19):5789-5801. Epub 2017 Jun 20.

Immunology in Cancer and Infection, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia.

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October 2017

Poor prognosis of patients with triple-negative breast cancer can be stratified by RANK and RANKL dual expression.

Authors:

Monica E Reyes Takeo Fujii Daniel Branstetter Savitri Krishnamurthy Hiroko Masuda Xiaoping Wang James M Reuben Wendy A Woodward Beatrice J Edwards Gabriel N Hortobagyi Debu Tripathy William C Dougall Bedrich L Eckhardt Naoto T Ueno

Breast Cancer Res Treat 2017 Jul 17;164(1):57-67. Epub 2017 Apr 17.

Morgan Welch Inflammatory Breast Cancer Research Program and Clinic, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

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July 2017

TIGIT and CD96: new checkpoint receptor targets for cancer immunotherapy.

Authors:

William C Dougall Sema Kurtulus Mark J Smyth Ana C Anderson

Immunol Rev 2017 03;276(1):112-120

Evergrande Center for Immunologic Diseases and Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.

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March 2017

Distribution of RANK and RANK Ligand in Normal Human Tissues as Determined by an Optimized Immunohistochemical Method.

Authors:

Clive R Taylor Daniel Branstetter Edward Manna William C Dougall Jeanine Bussiere Carol W Johnson

Appl Immunohistochem Mol Morphol 2017 May/Jun;25(5):299-307

*Department of Pathology, Keck School of Medicine, University of Southern California, Los Angeles ‡Dako, an Agilent technologies company, Carpinteria ∥Department of Comparative Biology and Safety Sciences ¶Formerly Department of Pathology, Amgen Inc., Thousand Oaks, CA †Formerly Department of Pathology §Department of Oncology Research, Amgen Inc., Seattle WA.

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November 2017