William D Figg

William D Figg

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William D Figg

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Reproducibility of pharmacogenetics findings for paclitaxel in a heterogeneous population of patients with lung cancer.

PLoS One 2019 28;14(2):e0212097. Epub 2019 Feb 28.

Clinical Pharmacology Program, Office of the Clinical Director, National Cancer Institute, Bethesda, Maryland, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212097PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6394902PMC
November 2019

A population pharmacokinetic analysis of the oral CYP17 lyase and androgen receptor inhibitor seviteronel in patients with advanced/metastatic castration-resistant prostate cancer or breast cancer.

Cancer Chemother Pharmacol 2019 Oct 31;84(4):759-770. Epub 2019 Jul 31.

Clinical Pharmacology Program, CCR, National Cancer Institute, NIH, 9000 Rockville Pike, Building 10, Room 5A01, Bethesda, MD, 20892, USA.

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http://dx.doi.org/10.1007/s00280-019-03908-0DOI Listing
October 2019

Cereblon gene variants and clinical outcome in multiple myeloma patients treated with lenalidomide.

Sci Rep 2019 Oct 16;9(1):14884. Epub 2019 Oct 16.

Genitourinary Malignancies Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA.

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http://dx.doi.org/10.1038/s41598-019-51446-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6795854PMC
October 2019

Combination treatment in metastatic castration-resistant prostate cancer: can we safely boost efficacy by adding radium-223?

Cancer Biol Ther 2019 Sep 18:1-3. Epub 2019 Sep 18.

Genitourinary Malignancies Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health , Bethesda , MD , USA.

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http://dx.doi.org/10.1080/15384047.2019.1665395DOI Listing
September 2019

Severe Hepatotoxicity of Mithramycin Therapy Caused by Altered Expression of Hepatocellular Bile Transporters.

Mol Pharmacol 2019 08 7;96(2):158-167. Epub 2019 Jun 7.

Clinical Pharmacology Program (T.M.S., C.J.P., W.D.F.), Molecular Pharmacology Section (P.A.H., R.J.H., E.M.M., R.H.B., J.D.S., A.M.L., W.D.F.), Biostatistics and Data Management Section (M.Z., J.A.H., D.V.), Pediatric Oncology Branch (P.G., J.G., B.C.W.), Thoracic Surgery Branch, Center for Cancer Research, National Cancer Institute (D.S.S.), and Translational Hepatology Section (T.H.), Liver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, Maryland; and BioIVT, ADME-Tox Division, Durham, North Carolina (J.P.J., K.R.B.)

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http://dx.doi.org/10.1124/mol.118.114827DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6608607PMC
August 2019

PBPK modeling-based optimization of site-specific chemo-photodynamic therapy with far-red light-activatable paclitaxel prodrug.

J Control Release 2019 Aug 9;308:86-97. Epub 2019 Jul 9.

Department of Pharmaceutical Sciences, College of Pharmacy, University of Oklahoma Health Sciences Center, Oklahoma City 73117, OK, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S01683659193039
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http://dx.doi.org/10.1016/j.jconrel.2019.07.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6710169PMC
August 2019

Antibody-drug conjugates for cancer.

Lancet 2019 08;394(10200):793-804

Molecular Pharmacology Section, Genitourinary Malignancies Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA. Electronic address:

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http://dx.doi.org/10.1016/S0140-6736(19)31774-XDOI Listing
August 2019

How do you take your coffee?

Lancet Oncol 2019 Jul;20(7):913-914

Clinical Pharmacology Program, Office of the Clinical Director, National Cancer Institute, Bethesda, MD 20892, USA. Electronic address:

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http://dx.doi.org/10.1016/S1470-2045(19)30387-0DOI Listing
July 2019

Detectible mosaic truncating PPM1D mutations, age and breast cancer risk.

J Hum Genet 2019 Jun 8;64(6):545-550. Epub 2019 Mar 8.

Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.

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http://dx.doi.org/10.1038/s10038-019-0589-1DOI Listing
June 2019

Molecular drivers of metastatic castrate-resistant prostate cancer: New roads to resistance.

Cancer Biol Ther 2018 14;19(10):869-870. Epub 2018 May 14.

a Genitourinary Malignancies Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health , Bethesda , MD , USA.

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http://dx.doi.org/10.1080/15384047.2018.1449618DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6300349PMC
May 2019

The effect of anti-CTLA4 treatment on peripheral and intra-tumoral T cells in patients with hepatocellular carcinoma.

Cancer Immunol Immunother 2019 Apr 28;68(4):599-608. Epub 2019 Jan 28.

Gastrointestinal Malignancies Section, Thoracic and GI Oncology Branch, Center for Cancer Research, National Cancer Institute (NCI), National Institutes of Health (NIH), Building 10, Room 3B43, Bethesda, MD, 20892, USA.

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http://dx.doi.org/10.1007/s00262-019-02299-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6662600PMC
April 2019

Alam K et al. (2018) Drug Metabolism Letters; 12, 24-32.

Drug Metab Lett 2018 ;12(2):153

Clinical Pharmacology Program, Office of the Clinical Director, and the Molecular Pharmacology Section, Genitourinary Malignancies Branch, National Cancer Institute, Bethesda, MD, United States.

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http://dx.doi.org/10.2174/1872312812999180724145725DOI Listing
February 2019

Insulin potentiation therapy for cancer?

Lancet Oncol 2019 Feb;20(2):191-192

Clinical Pharmacology Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA. Electronic address:

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http://dx.doi.org/10.1016/S1470-2045(19)30003-8DOI Listing
February 2019

Low Doses of CPS49 and Flavopiridol Combination as Potential Treatment for Advanced Prostate Cancer.

Curr Pharm Biotechnol 2019;20(12):1072

Laboratorio de Oncologia Molecular y Nuevos Blancos Terapeuticos, Instituto de Biologia y Medicina Experimental (IBYME-CONICET), Buenos Aires, Argentina.

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http://dx.doi.org/10.2174/138920102012190919103433DOI Listing
January 2019

Synthesis, Structural Characterization, and Antiangiogenic Activity of Polyfluorinated Benzamides.

ChemMedChem 2018 10 6;13(19):2080-2089. Epub 2018 Sep 6.

Pharmaceutical Institute, Pharmaceutical Chemistry I, University of Bonn, An der Immenburg 4, 53121, Bonn, Germany.

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http://dx.doi.org/10.1002/cmdc.201800263DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6631341PMC
October 2018

Optimized administration of hetIL-15 expands lymphocytes and minimizes toxicity in rhesus macaques.

Cytokine 2018 08 7;108:213-224. Epub 2018 May 7.

Human Retrovirus Section, Vaccine Branch, Center for Cancer Research, National Cancer Institute at Frederick, Frederick, MD, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cyto.2018.01.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6657354PMC
August 2018

Novel Fluoroindenoisoquinoline Non-Camptothecin Topoisomerase I Inhibitors.

Mol Cancer Ther 2018 08 10;17(8):1694-1704. Epub 2018 May 10.

Developmental Therapeutics Branch & Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland.

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http://mct.aacrjournals.org/lookup/doi/10.1158/1535-7163.MCT
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http://dx.doi.org/10.1158/1535-7163.MCT-18-0028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6072611PMC
August 2018

Revisiting 5α-reductase inhibitors and the risk of prostate cancer.

Nat Rev Urol 2018 Jul;15(7):400-401

Genitourinary Malignancies Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.

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http://dx.doi.org/10.1038/s41585-018-0018-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6358277PMC
July 2018

Preclinical Evaluation of Discorhabdins in Antiangiogenic and Antitumor Models.

Mar Drugs 2018 Jul 19;16(7). Epub 2018 Jul 19.

Molecular Pharmacology Section, Genitourinary Malignancies Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.3390/md16070241DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6071056PMC
July 2018

A sensitive and rapid ultra high-performance liquid chromatography with tandem mass spectrometric assay for the simultaneous quantitation of cyclophosphamide and the 4-hydroxycyclophosphamide metabolite in human plasma.

J Chromatogr B Analyt Technol Biomed Life Sci 2018 Jun 10;1086:56-62. Epub 2018 Apr 10.

Clinical Pharmacology Program, National Cancer Institute, Bethesda, MD, United States. Electronic address:

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http://dx.doi.org/10.1016/j.jchromb.2018.04.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5927828PMC
June 2018

Antineoplastons: when is enough enough?

Authors:
William D Figg

Lancet Oncol 2018 Jun 1;19(6):733-734. Epub 2018 Jun 1.

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http://dx.doi.org/10.1016/S1470-2045(18)30338-3DOI Listing
June 2018

Precision medicine applications in prostate cancer.

Ther Adv Med Oncol 2018 18;10:1758835918776920. Epub 2018 Jun 18.

Clinical Pharmacology Program, Office of the Clinical Director, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Rockville Pike, Bldg 10/Room 5A01, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1177/1758835918776920DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6024288PMC
June 2018

Design, synthesis and biological assessment of N-adamantyl, substituted adamantyl and noradamantyl phthalimidines for nitrite, TNF-α and angiogenesis inhibitory activities.

Bioorg Med Chem 2018 05 10;26(8):1547-1559. Epub 2018 Feb 10.

Drug Design & Development Section, Translational Gerontology Branch, Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA.

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http://dx.doi.org/10.1016/j.bmc.2018.01.032DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5891396PMC
May 2018

Prospective International Randomized Phase II Study of Low-Dose Abiraterone With Food Versus Standard Dose Abiraterone In Castration-Resistant Prostate Cancer.

J Clin Oncol 2018 05 28;36(14):1389-1395. Epub 2018 Mar 28.

Russell Z. Szmulewitz, Abiola Ibraheem, Elia Martinez, Mark F. Kozloff, Chadi Nabhan, Theodore Karrison, Walter M. Stadler, and Mark J. Ratain, The University of Chicago, Chicago; Mark F. Kozloff, Ingalls Hospital, Harvey; Paul Fishkin, Illinois Cancer Care, Peoria, IL; Cody J. Peer and William D. Figg, National Cancer Institute, Rockville, MD; Bradley Carthon and R. Donald Harvey, Winship Cancer Institute of Emory University, Atlanta, GA; and Wei Peng Yong and Edmund Chiong, National University Cancer Institute, Singapore, Singapore.

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http://ascopubs.org/doi/10.1200/JCO.2017.76.4381
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http://dx.doi.org/10.1200/JCO.2017.76.4381DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5941614PMC
May 2018

Tissue preservation with mass spectroscopic analysis: Implications for cancer diagnostics.

Cancer Biol Ther 2018 31;19(11):953-955. Epub 2018 May 31.

a Clinical Pharmacology Program , National Cancer Institute , Bethesda , MD.

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https://www.tandfonline.com/doi/full/10.1080/15384047.2018.1
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http://dx.doi.org/10.1080/15384047.2018.1456610DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6301822PMC
May 2018

CPS49-induced neurotoxicity does not cause limb patterning anomalies in developing chicken embryos.

J Anat 2018 04 10;232(4):568-574. Epub 2017 Oct 10.

School of Medicine, Medical Sciences and Nutrition, Institute of Medical Sciences, University of Aberdeen, Aberdeen, UK.

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http://dx.doi.org/10.1111/joa.12712DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5835787PMC
April 2018

Expanding the use of abiraterone in prostate cancer: Is earlier always better?

Cancer Biol Ther 2018 02 8;19(2):97-100. Epub 2017 Dec 8.

a Clinical Pharmacology Program, Office of the Clinical Director , National Cancer Institute, NIH , Bethesda , MD , USA.

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http://dx.doi.org/10.1080/15384047.2017.1394555DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5790360PMC
February 2018

The effect of an adenosine A agonist on intra-tumoral concentrations of temozolomide in patients with recurrent glioblastoma.

Fluids Barriers CNS 2018 Jan 15;15(1). Epub 2018 Jan 15.

Brain Cancer Program, Johns Hopkins University, David H. Koch Cancer Research Building II, 1550 Orleans Street, Room 1M16, Baltimore, MD, 21287, USA.

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http://dx.doi.org/10.1186/s12987-017-0088-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5767971PMC
January 2018

Quantitative modeling of the dynamics and intracellular trafficking of far-red light-activatable prodrugs: implications in stimuli-responsive drug delivery system.

J Pharmacokinet Pharmacodyn 2017 Dec 14;44(6):521-536. Epub 2017 Sep 14.

Department of Pharmaceutical Sciences, College of Pharmacy, University of Oklahoma Health Sciences Center, Oklahoma City, OK, 73117, USA.

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http://dx.doi.org/10.1007/s10928-017-9543-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5688019PMC
December 2017

Jumping the Barrier: Modeling Drug Penetration across the Blood-Brain Barrier.

Clin Cancer Res 2017 12 10;23(24):7437-7439. Epub 2017 Oct 10.

Clinical Pharmacology Program, National Cancer Institute, National Institutes of Health, Bethesda, Maryland.

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http://dx.doi.org/10.1158/1078-0432.CCR-17-2741DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5732885PMC
December 2017

Exosome is a mechanism of intercellular drug transfer: Application of quantitative pharmacology.

J Control Release 2017 Dec 18;268:147-158. Epub 2017 Oct 18.

Department of Pharmaceutical Sciences, College of Pharmacy, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73117, USA; Institute of Quantitative Systems Pharmacology, Carlsbad, CA 92008, USA; Optimum Therapeutics LLC, Carlsbad, CA 92008, USA; College of Pharmacy, Taipei Medical University, Taipei, Taiwan. Electronic address:

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http://dx.doi.org/10.1016/j.jconrel.2017.10.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5722714PMC
December 2017

Cellular identity crisis: Antiandrogen resistance by lineage plasticity.

Cancer Biol Ther 2017 Nov 5;18(11):841-842. Epub 2017 May 5.

a Clinical Pharmacology Program , Medical Oncology Branch, CCR, NCI/NIH, National Cancer Institute , Bethesda , MD , USA.

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http://dx.doi.org/10.1080/15384047.2017.1323599DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5710664PMC
November 2017

Discussing the predictive, prognostic, and therapeutic value of germline DNA-repair gene mutations in metastatic prostate cancer patients.

Cancer Biol Ther 2017 08 5;18(8):545-546. Epub 2017 Jul 5.

a Molecular Pharmacology Section, Genitourinary Malignancies Branch , National Institutes of Health , Bethesda , MD , USA.

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http://dx.doi.org/10.1080/15384047.2017.1345398DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5653188PMC
August 2017

Safety and Clinical Activity of the Programmed Death-Ligand 1 Inhibitor Durvalumab in Combination With Poly (ADP-Ribose) Polymerase Inhibitor Olaparib or Vascular Endothelial Growth Factor Receptor 1-3 Inhibitor Cediranib in Women's Cancers: A Dose-Escalation, Phase I Study.

J Clin Oncol 2017 Jul 4;35(19):2193-2202. Epub 2017 May 4.

Jung-Min Lee, Cody J. Peer, Alexandra Zimmer, Stanley Lipkowitz, Christina M. Annunziata, Liang Cao, Nicole Houston, Dana-Adriana Botesteanu, Jeffers Nguyen, William D. Figg, and Elise C. Kohn, Center for Cancer Research, National Cancer Institute, Bethesda; Ashley Cimino-Mathews, Janis M. Taube, Elizabeth Thompson, Aleksandra Ogurtsova, and Haiying Xu, The Johns Hopkins Medical Institution, Baltimore; and Tony W. Ho, AstraZeneca, Gaithersburg, MD; and Maria I. Harrell and Elizabeth M. Swisher, University of Washington, Seattle, WA.

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http://dx.doi.org/10.1200/JCO.2016.72.1340DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5493052PMC
July 2017

Diagnosis, staging, and risk stratification in prostate cancer: Utilizing diagnostic tools to avoid unnecessary therapies and side effects.

Cancer Biol Ther 2017 Jul 5;18(7):470-472. Epub 2017 May 5.

a Clinical Pharmacology Program , Office of the Clinical Director, National Cancer Institute, National Institutes of Health , Bethesda , MD , USA.

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http://dx.doi.org/10.1080/15384047.2017.1323600DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5639830PMC
July 2017

Carfilzomib and lenalidomide response related to VEGF and VEGFR2 germline polymorphisms.

Cancer Chemother Pharmacol 2017 Jul 9;80(1):217-221. Epub 2017 May 9.

Clinical Pharmacology Program, Office of the Clinical Director, National Cancer Institute, 9000 Rockville Pike, Building 10, Rm 5A01, Bethesda, MD, 20892, USA.

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http://dx.doi.org/10.1007/s00280-017-3323-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6387687PMC
July 2017

Population pharmacokinetic analyses of the effect of carboplatin pretreatment on olaparib in recurrent or refractory women's cancers.

Cancer Chemother Pharmacol 2017 Jul 2;80(1):165-175. Epub 2017 Jun 2.

Clinical Pharmacology Program, CCR, National Cancer Institute, NIH, 9000 Rockville Pike, Building 10, Room 5A01, Bethesda, MD, 20892, USA.

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http://dx.doi.org/10.1007/s00280-017-3346-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6361113PMC
July 2017

Vertebrate embryos as tools for anti-angiogenic drug screening and function.

Reprod Toxicol 2017 06 22;70:49-59. Epub 2016 Nov 22.

School of Medicine, Medical Sciences and Nutrition, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen, UK. Electronic address:

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http://dx.doi.org/10.1016/j.reprotox.2016.11.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6357960PMC
June 2017

A new predictive tool for postoperative radiotherapy in prostate cancer.

Cancer Biol Ther 2017 05 18;18(5):277-278. Epub 2017 Apr 18.

a Center for Cancer Research , National Cancer Institute, National Institutes of Health , Bethesda , MD , USA.

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http://dx.doi.org/10.1080/15384047.2017.1310347DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5499754PMC
May 2017

Pharmacokinetics of Pomalidomide in a Patient Receiving Hemodialysis Using a High-Cutoff Filter.

Am J Kidney Dis 2017 Apr 4;69(4):553-554. Epub 2017 Jan 4.

Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.

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http://dx.doi.org/10.1053/j.ajkd.2016.10.026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6667183PMC
April 2017

Genome-wide analysis of clopidogrel active metabolite levels identifies novel variants that influence antiplatelet response.

Pharmacogenet Genomics 2017 04;27(4):159-163

aSchool of Medicine, Division of Endocrinology, Diabetes and Nutrition, and Program for Personalized and Genomic Medicine, University of Maryland, Baltimore bGeriatric Research and Education Clinical Center, Veterans Administration Medical Center, Baltimore cClinical Pharmacology Program, National Cancer Institute, Bethesda dApplied and Developmental Research, SAIC-Frederick Inc., National Cancer Institute, Frederick, Maryland, USA.

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http://dx.doi.org/10.1097/FPC.0000000000000272DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5346037PMC
April 2017

Piecing the puzzle together: Docetaxel cycles and current considerations in the treatment of metastatic castration-resistant prostate cancer.

Cancer Biol Ther 2017 04 25;18(4):203-204. Epub 2017 Feb 25.

a Genitourinary Malignancies Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health , Bethesda , MD , USA.

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http://dx.doi.org/10.1080/15384047.2017.1295192DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5450733PMC
April 2017

A simple and rapid UHPLC-MS/MS method for the quantitation of the dual aurora kinase A/B inhibitor SCH-1473759 in murine plasma.

J Pharm Biomed Anal 2017 Jan 5;132:223-226. Epub 2016 Oct 5.

Clinical Pharmacology Program, Office of the Clinical Director, National Cancer Institute, Bethesda, MD, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S07317085163079
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http://dx.doi.org/10.1016/j.jpba.2016.10.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6357958PMC
January 2017

Pharmacokinetics of lenalidomide during high cut-off dialysis in a patient with multiple myeloma and renal failure.

Cancer Chemother Pharmacol 2017 Jan 17;79(1):215-218. Epub 2016 Dec 17.

Service of Nephrology, Department of Medicine, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.

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http://dx.doi.org/10.1007/s00280-016-3219-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6410697PMC
January 2017

Precision Oncology Medicine: The Clinical Relevance of Patient-Specific Biomarkers Used to Optimize Cancer Treatment.

J Clin Pharmacol 2016 12 17;56(12):1484-1499. Epub 2016 Jun 17.

Clinical Pharmacology Program, Office of the Clinical Director, NIH, Bethesda, MD, USA.

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http://dx.doi.org/10.1002/jcph.765DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5112148PMC
December 2016

Synthesis and Antiangiogenic Properties of Tetrafluorophthalimido and Tetrafluorobenzamido Barbituric Acids.

ChemMedChem 2016 Dec 2;11(23):2621-2629. Epub 2016 Nov 2.

Pharmaceutical Institute, Pharmaceutical Chemistry I, University of Bonn, An der Immenburg 4, 53121, Bonn, Germany.

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http://dx.doi.org/10.1002/cmdc.201600496DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6438167PMC
December 2016

Androgen receptor variation affects prostate cancer progression and drug resistance.

Pharmacol Res 2016 12 7;114:152-162. Epub 2016 Oct 7.

Molecular Pharmacology Section, Genitourinary Malignancies Branch, National Cancer Institute, Bethesda, MD, United States; The Clinical Pharmacology Program, Office of the Clinical Director, National Cancer Institute, Bethesda, MD, United States. Electronic address:

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http://dx.doi.org/10.1016/j.phrs.2016.10.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5154811PMC
December 2016

Pomalidomide for Symptomatic Kaposi's Sarcoma in People With and Without HIV Infection: A Phase I/II Study.

J Clin Oncol 2016 12 31;34(34):4125-4131. Epub 2016 Oct 31.

Mark N. Polizzotto, Thomas S. Uldrick, Kathleen M. Wyvill, Karen Aleman, Cody J. Peer, Frank Maldarelli, Priscila H. Goncalves, William D. Figg, Seth M. Steinberg, and Robert Yarchoan, National Cancer Institute; Margaret Bevans, National Institutes of Health; Irini Sereti, National Institute of Allergy and Infectious Diseases, Bethesda, MD; Denise Whitby and Vickie Marshall, Frederick National Cancer Laboratory for Cancer Research, Frederick, MD; and Vikram Khetani and Jerome B. Zeldis, Celgene Corporation, Summit, NJ.

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http://dx.doi.org/10.1200/JCO.2016.69.3812DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5477825PMC
December 2016

Identification of novel SNPs associated with risk and prognosis in patients with castration-resistant prostate cancer.

Pharmacogenomics 2016 Dec 24;17(18):1979-1986. Epub 2016 Nov 24.

Clinical Pharmacology Program, Office of the Clinical Director, National Cancer Institute, 9000 Rockville Pike, Building 10, Room 5A01, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.2217/pgs-2016-0134DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5558514PMC
December 2016

Pharmacogenomics and histone deacetylase inhibitors.

Pharmacogenomics 2016 11 21;17(16):1807-1815. Epub 2016 Oct 21.

Clinical Pharmacology Program, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.2217/pgs-2016-0113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5558504PMC
November 2016

The potential role of curcumin in prostate cancer: the importance of optimizing pharmacokinetics in clinical studies.

Transl Cancer Res 2016 Nov;5(Suppl 6):S1107-S1110

Clinical Pharmacology Program, Office of the Clinical Director, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.

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http://tcr.amegroups.com/article/view/10421/9343
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http://dx.doi.org/10.21037/tcr.2016.11.04DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6320229PMC
November 2016

Erratum to: Association of a CYP17 Polymorphism With Overall Survival in Caucasian Patients With Androgen-independent Prostate Cancer.

Urology 2016 09 14;95:225. Epub 2016 Jul 14.

Clinical Pharmacology Program, National Cancer Institute, Bethesda, MD. Electronic address:

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http://dx.doi.org/10.1016/j.urology.2016.05.047DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5676461PMC
September 2016

Building a hit list for the fight against metastatic castration resistant prostate cancer.

Cancer Biol Ther 2016 29;17(3):231-2. Epub 2016 Jan 29.

a Genitourinary Malignancies Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health , Bethesda , MD , USA.

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http://dx.doi.org/10.1080/15384047.2016.1139270DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4847990PMC
July 2016

Shared mechanism of teratogenicity of anti-angiogenic drugs identified in the chicken embryo model.

Sci Rep 2016 07 22;6:30038. Epub 2016 Jul 22.

School of Medicine, Medical Sciences and Nutrition, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen, UK.

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http://dx.doi.org/10.1038/srep30038DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4957076PMC
July 2016

YAP controls transcriptional elongation through CKD9 recruitment for proximal pause release: "Hippo-thetical", new therapeutic targets?

Cancer Biol Ther 2016 06 5;17(6):592-4. Epub 2016 May 5.

a Genitourinary Malignancies Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health , Bethesda , MD , USA.

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http://dx.doi.org/10.1080/15384047.2016.1178883DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4990395PMC
June 2016

Androgen receptor splice variant 7 (AR-V7) and drug efficacy in castration-resistant prostate cancer: Biomarker for treatment selection exclusion or inclusion?

Cancer Biol Ther 2016 05 17;17(5):467-9. Epub 2016 Mar 17.

a Molecular Pharmacology Section, Genitourinary Malignancies Branch, National Cancer Institute, National Institutes of Health , Bethesda , Maryland , USA.

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http://dx.doi.org/10.1080/15384047.2016.1156274DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4910935PMC
May 2016

In vivo screening and discovery of novel candidate thalidomide analogs in the zebrafish embryo and chicken embryo model systems.

Oncotarget 2016 May;7(22):33237-45

School of Medicine, Medical Sciences and Nutrition, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen, UK.

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http://dx.doi.org/10.18632/oncotarget.8909DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5078090PMC
May 2016

Resisting resistance: Establishing new treatment options for CRPC patients.

Cancer Biol Ther 2016 04 30;17(4):337-8. Epub 2016 Jan 30.

a Molecular Pharmacology Section, National Cancer Institute, National Institutes of Health Bethesda , Maryland , USA.

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http://dx.doi.org/10.1080/15384047.2016.1139271DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4910910PMC
April 2016

UGT genotyping in belinostat dosing.

Pharmacol Res 2016 Mar 7;105:22-7. Epub 2016 Jan 7.

Clinical Pharmacology Program, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA. Electronic address:

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http://dx.doi.org/10.1016/j.phrs.2016.01.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4775324PMC
March 2016

Using Epigenetic Therapy to Overcome Chemotherapy Resistance.

Anticancer Res 2016 Jan;36(1):1-4

Genitourinary Malignancies Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, U.S.A.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6388403PMC
January 2016