Publications by authors named "William Chan"

100Publications

Temporal trends in patient risk profile and clinical outcomes following percutaneous coronary intervention.

Cardiovasc Revasc Med 2020 Dec 17. Epub 2020 Dec 17.

Department of Cardiology, Royal Melbourne Hospital, Melbourne, Victoria, Australia; Centre of Cardiovascular Research and Education in Therapeutics, Monash University, Melbourne, Victoria, Australia; Melbourne University, Melbourne, Victoria, Australia. Electronic address:

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December 2020

Comparison of methods for texture analysis of QUS parametric images in the characterization of breast lesions.

PLoS One 2020 31;15(12):e0244965. Epub 2020 Dec 31.

Department of Radiation Oncology, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada.

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December 2020

Utility of 3-D printing for cardiac resynchronization device implantation in congenital heart disease.

HeartRhythm Case Rep 2020 Oct 22;6(10):754-756. Epub 2020 Jul 22.

Division of Cardiology, Schulich School of Medicine and Dentistry, Western University, London, Ontario, Canada.

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October 2020

V-A-A-V response to ventricular entrainment: What is the mechanism of this SVT?

J Cardiovasc Electrophysiol 2020 Nov 5;31(11):3028-3030. Epub 2020 Oct 5.

Arrhythmia Service, University Hospital, University of Western Ontario, London Health Sciences Centre, London, Ontario, Canada.

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November 2020

Relation of Timing of Percutaneous Coronary Intervention on Outcomes in Patients With Non-ST Segment Elevation Myocardial Infarction.

Am J Cardiol 2020 12 16;136:15-23. Epub 2020 Sep 16.

Department of Cardiology, Alfred Health, Melbourne, Australia; Monash University, Melbourne, Australia; Department of Cardiology, Western Health, Melbourne, Australia. Electronic address:

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December 2020

A simple maneuver to determine if septal accessory pathway ablation requires a left atrial approach.

J Cardiovasc Electrophysiol 2020 Dec 24;31(12):3207-3214. Epub 2020 Sep 24.

Division of Cardiology, Schulich School of Medicine and Dentistry, Western University, London, Ontario, Canada.

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December 2020

Selective Autophagy Maintains the Aryl Hydrocarbon Receptor Levels in HeLa Cells: A Mechanism That Is Dependent on the p23 Co-Chaperone.

Int J Mol Sci 2020 May 13;21(10). Epub 2020 May 13.

Department of Pharmaceutics & Medicinal Chemistry, Thomas J. Long School of Pharmacy, University of the Pacific, Stockton, CA 95211, USA.

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May 2020

Long-term outcomes following percutaneous coronary intervention to an unprotected left main coronary artery in cardiogenic shock.

Int J Cardiol 2020 06 3;308:20-25. Epub 2020 Mar 3.

Department of Cardiology, Austin Health, Melbourne, Australia; Centre of Cardiovascular Research and Education in Therapeutics (CCRET), Monash University, Melbourne, Australia. Electronic address:

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June 2020

Preoperative biomarker evaluation for the prediction of cardiovascular events after major vascular surgery.

J Vasc Surg 2019 11;70(5):1564-1575

Department of Cardiovascular Medicine, Alfred Hospital, Melbourne, Victoria, Australia; Baker IDI Heart and Diabetes Institute, Melbourne, Victoria, Australia. Electronic address:

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November 2019

Surveillance of transmitted HIV drug resistance among newly diagnosed, treatment-naive individuals at a county HIV clinic in Santa Clara County.

Heliyon 2019 Sep 11;5(9):e02411. Epub 2019 Sep 11.

School of Medicine, University of California, San Francisco, CA, USA.

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September 2019

Non-invasive Risk Stratification for Coronary Artery Disease: Is It Time for Subclassifications?

Curr Cardiol Rep 2019 07 25;21(8):87. Epub 2019 Jul 25.

Northern and Central Adelaide Local Network, University of Adelaide, Adelaide, Australia.

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July 2019

The Impact of Out-of-Hours Presentation on Clinical Outcomes in ST-Elevation Myocardial Infarction.

Heart Lung Circ 2020 Jun 22;29(6):814-823. Epub 2019 Jun 22.

Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Vic, Australia; Department of Cardiology, The Alfred Hospital, Melbourne, Vic, Australia; Baker IDI Heart and Diabetes Institute, Melbourne, Vic, Australia. Electronic address:

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June 2020

Risk-to-Benefit Relationship of Contralateral Prophylactic Mastectomy: The Argument for Bilateral Mastectomies with Immediate Reconstruction.

Plast Reconstr Surg 2019 07;144(1):1-9

From the Division of Plastic and Reconstructive Surgery, The Donald and Barbara Zucker School of Medicine at Hofstra/Northwell; and the Division of Plastic and Reconstructive Surgery, Northwell Health.

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July 2019

Aryl hydrocarbon receptor acts as a tumor suppressor in a syngeneic MC38 colon carcinoma tumor model.

Hypoxia (Auckl) 2019 10;7:1-16. Epub 2019 Apr 10.

Department of Pharmaceutics and Medicinal Chemistry, Thomas J Long School of Pharmacy & Health Sciences, University of the Pacific, Stockton, CA, 95211, USA.

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April 2019

Risk stratification for coronary artery disease in multi-ethnic populations: Are there broader considerations for cost efficiency?

World J Methodol 2019 Jan 18;9(1):1-19. Epub 2019 Jan 18.

Department of Cardiology, The Alfred Hospital, Baker IDI Heart and Diabetes Institute, Melbourne, Vic 3004, Australia.

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January 2019

Single Versus Dual Lead Atrioventricular Sequential Pacing for Acquired Atrioventricular Block During Transcatheter Aortic Valve Implantation Procedures.

Am J Cardiol 2018 08 20;122(4):633-637. Epub 2018 Jun 20.

Schulich Heart Centre and the Department of Medicine, Sunnybrook Health Sciences Centre, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada. Electronic address:

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August 2018

Down-Regulation of p23 in Normal Lung Epithelial Cells Reduces Toxicities From Exposure to Benzo[a]pyrene and Cigarette Smoke Condensate via an Aryl Hydrocarbon Receptor-Dependent Mechanism.

Toxicol Sci 2019 01;167(1):239-248

Department of Pharmaceutics and Medicinal Chemistry, Thomas J. Long School of Pharmacy and Health Sciences, University of the Pacific, Stockton, California 95211.

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January 2019

p23 protects the human aryl hydrocarbon receptor from degradation via a heat shock protein 90-independent mechanism.

Biochem Pharmacol 2018 06 17;152:34-44. Epub 2018 Mar 17.

Department of Pharmaceutics & Medicinal Chemistry, Thomas J. Long School of Pharmacy & Health Sciences, University of the Pacific, Stockton, CA 95211, United States. Electronic address:

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June 2018

Changes in Statin Prescription Patterns in Patients Admitted to an Australian Geriatric Subacute Unit.

Heart Lung Circ 2019 Mar 31;28(3):423-429. Epub 2018 Jan 31.

Cardiology Unit, Western Health, Melbourne, Vic, Australia; Department of Cardiovascular Medicine, Alfred Hospital, Melbourne, Vic, Australia; Monash University, Melbourne, Vic, Australia; Melbourne Medical School, Faculty of Medicine, Dentistry, and Health Sciences, The University of Melbourne, Melbourne, Vic, Australia; Baker Heart and Diabetes Institute, Melbourne, Vic, Australia. Electronic address:

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March 2019

Rapid and safe discharge from the emergency department: A single troponin to exclude acute myocardial infarction.

Emerg Med Australas 2018 08 8;30(4):486-493. Epub 2018 Jan 8.

Emergency and Trauma Centre, The Alfred Hospital, Melbourne, Victoria, Australia.

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August 2018

Australian Trends in Procedural Characteristics and Outcomes in Patients Undergoing Percutaneous Coronary Intervention for ST-Elevation Myocardial Infarction.

Am J Cardiol 2018 02 31;121(3):279-288. Epub 2017 Oct 31.

Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Australia; Department of Cardiovascular Medicine, The Alfred Hospital, Melbourne, Australia; Baker IDI Heart and Diabetes Institute, Melbourne, Australia. Electronic address:

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February 2018

Trends and Clinical Outcomes in Patients Undergoing Primary Percutaneous Revascularisation for ST-Elevation Myocardial Infarction: A Single Centre Experience.

Heart Lung Circ 2018 Jun 14;27(6):683-692. Epub 2017 Jul 14.

Department of Cardiology, The Alfred Hospital, Melbourne, Vic, Australia; Baker IDI Heart and Diabetes Institute, Melbourne, Vic, Australia. Electronic address:

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June 2018

Evidence of acute giant cell reaction post bioresorbable vascular scaffold implantation.

EuroIntervention 2017 12;13(11):1345-1346

Department of Cardiology, Western Health, Melbourne, Australia.

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December 2017

Progress on lipid extraction from wet algal biomass for biodiesel production.

Microb Biotechnol 2016 11 19;9(6):718-726. Epub 2016 May 19.

Algae Biotechnology Laboratory, School of Agriculture and Food Sciences, The University of Queensland, Brisbane, QLD, 4072, Australia.

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November 2016

Adjunctive Bare-Metal Stenting Associated With Improved Outcomes in Patients With Multivessel Disease Treated With Drug-Eluting Stents.

Can J Cardiol 2016 10 9;32(10):1231-1238. Epub 2015 Dec 9.

Division of Cardiology, Peter Munk Cardiac Centre, University Health Network, Toronto, Ontario, Canada. Electronic address:

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October 2016

Selective suppression of the human aryl hydrocarbon receptor function can be mediated through binding interference at the C-terminal half of the receptor.

Biochem Pharmacol 2016 May 9;107:91-100. Epub 2016 Mar 9.

Department of Pharmaceutics & Medicinal Chemistry, Thomas J. Long School of Pharmacy & Health Sciences, University of the Pacific, Stockton, CA 95211, United States. Electronic address:

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May 2016

Binding studies using Pichia pastoris expressed human aryl hydrocarbon receptor and aryl hydrocarbon receptor nuclear translocator proteins.

Protein Expr Purif 2016 06 23;122:72-81. Epub 2016 Feb 23.

Department of Pharmaceutics and Medicinal Chemistry, Thomas J. Long School of Pharmacy and Health Sciences, University of the Pacific, Stockton, CA 95211, USA. Electronic address:

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June 2016

Clinical Characteristics, Management, and Outcomes of Acute Coronary Syndrome in Patients With Right Bundle Branch Block on Presentation.

Am J Cardiol 2016 Mar 12;117(5):754-9. Epub 2015 Dec 12.

Terrence Donnelly Heart Centre, Department of Medicine, St Michael's Hospital, Toronto, Canada; University of Toronto, Toronto, Canada. Electronic address:

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March 2016

The pulmonary artery wedge pressure response to sustained exercise is time-variant in healthy adults.

Heart 2016 Mar 13;102(6):438-43. Epub 2016 Jan 13.

Institute of Medical Science, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada Division of Cardiology, Mount Sinai Hospital/University Health Network, Toronto, Ontario, Canada.

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March 2016

A biomimetic approach for enhancing the in vivo half-life of peptides.

Nat Chem Biol 2015 Oct 7;11(10):793-8. Epub 2015 Sep 7.

Department of Pharmaceutics &Medicinal Chemistry, Thomas J. Long School of Pharmacy &Health Sciences, University of the Pacific, Stockton, California, USA.

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October 2015

Post-Infarction LV Remodeling: Remote Changes Do Not Necessarily Occur Remotely From Time of Infarction.

JACC Cardiovasc Imaging 2015 Jul;8(7):790-2

Department of Cardiovascular Medicine, Alfred Hospital and the Baker IDI Heart and Diabetes Institute, Melbourne, Australia.

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July 2015

Ventricular Fibrillation Precipitated by Intracoronary Adenosine During Fractional Flow Reserve Assessment - A Cautionary Tale.

Heart Lung Circ 2015 Nov 30;24(11):e173-5. Epub 2015 Jun 30.

Division of Cardiology, Peter Munk Cardiac Centre, Toronto General Hospital, University Health Network, Toronto, Ontario, Canada. Electronic address:

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November 2015

Genetic ablation of PRAS40 improves glucose homeostasis via linking the AKT and mTOR pathways.

Biochem Pharmacol 2015 Jul 27;96(1):65-75. Epub 2015 Apr 27.

Department of Physiology and Pharmacology, T. J. Long School of Pharmacy & Health Sciences, University of the Pacific, Stockton, CA, United States. Electronic address:

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July 2015

Clinical outcomes of treatment by percutaneous coronary intervention versus coronary artery bypass graft surgery in patients with chronic kidney disease undergoing index revascularization in Ontario.

Circ Cardiovasc Interv 2015 Jan;8(1)

From the Department of Medicine (W.C., J.I., C.B.O., V.D.), and Department of Surgery (V.R.), Peter Munk Cardiac Centre, University Health Network, Toronto, Ontario, Canada; Department of Medicine, Institute for Clinical and Evaluative Sciences, Toronto, Ontario, Canada (J.I., D.K., J.V.T.); Department of Medicine (D.K., J.V.T.), and Department of Surgery (S.F.), Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada; Department of Medicine, Hamilton General Hospital, Hamilton, Ontario, Canada (S.J.); Department of Medicine, Southlake Regional Health Centre, Newmarket, Ontario, Canada (W.J.C.); Department of Medicine, London Health Sciences Centre, London, Ontario, Canada (S.L.); and Department of Surgery, University of Ottawa Heart Institute, Ottawa, Ontario, Canada (M.R.).

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January 2015

Long-term outcome of unprotected left main stenting: a Canadian tertiary care experience.

Can J Cardiol 2014 Nov 27;30(11):1407-14. Epub 2014 Jun 27.

Peter Munk Cardiac Centre, University Health Network, Toronto, Ontario, Canada. Electronic address:

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November 2014

Association between drug-eluting stent type and clinical outcomes in patients with chronic kidney disease undergoing percutaneous coronary intervention.

Can J Cardiol 2014 Oct 6;30(10):1170-6. Epub 2014 May 6.

Division of Cardiology, Peter Munk Cardiac Centre, Toronto General Hospital, University Health Network, Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada. Electronic address:

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October 2014

Complex coronary artery bifurcation treatment utilizing everolimus-eluting bioresorbable vascular scaffolds and optical coherence tomography.

Coron Artery Dis 2014 Nov;25(7):629-31

Division of Cardiology, Peter Munk Cardiac Centre, Toronto General Hospital, University Health Network, Toronto, Ontario, Canada.

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November 2014

Angiographic and echocardiographic correlates of suitable septal perforators for alcohol septal ablation in hypertrophic obstructive cardiomyopathy.

Can J Cardiol 2014 Aug 13;30(8):912-9. Epub 2014 Apr 13.

Division of Cardiology, Peter Munk Cardiac Centre, Toronto General Hospital, University Health Network, Toronto, Ontario, Canada. Electronic address:

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August 2014

Comparison of different intubation techniques performed inside a moving ambulance: a manikin study.

Hong Kong Med J 2014 Aug 6;20(4):304-12. Epub 2014 Jun 6.

Department of Accident and Emergency, Tuen Mun Hospital, Tuen Mun, Hong Kong; Auxiliary Medical Service, AMS Headquarters, 81 Princess Margaret Road, Hong Kong.

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August 2014

T cells generated in the absence of a thoracic thymus fail to establish homeostasis.

Eur J Immunol 2014 Aug 23;44(8):2263-73. Epub 2014 May 23.

Department of Medical Microbiology and Immunology, University of Alberta, Edmonton, AB, Canada.

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August 2014

Expression of P-glycoprotein and CYP3A4 along the porcine oral-gastrointestinal tract: implications on oral mucosal drug delivery.

Drug Dev Ind Pharm 2014 May 7;40(5):599-603. Epub 2014 Feb 7.

Department of Pharmaceutics and Medicinal Chemistry, Thomas J. Long School of Pharmacy and Health Sciences, University of the Pacific , Stockton, CA , USA and.

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May 2014

Innovations in hip fracture care: a comparison of geriatric fracture centers.

J Am Med Dir Assoc 2014 Apr 26;15(4):232-3. Epub 2014 Feb 26.

Department of Orthopaedic Surgery, Tan Tock Seng Hospital, Singapore.

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April 2014

Trans-aortic percutaneous heart valve deployment of Impella CP(TM) to assist in high-risk percutaneous coronary intervention.

Heart Lung Circ 2014 May 24;23(5):e142-4. Epub 2014 Jan 24.

Division of Cardiology, Peter Munk Cardiac Centre, Toronto General Hospital, University Health Network, Toronto, Ontario, Canada.

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May 2014

Differential suppression of the aryl hydrocarbon receptor nuclear translocator-dependent function by an aryl hydrocarbon receptor PAS-A-derived inhibitory molecule.

Biochem Pharmacol 2014 Mar 28;88(2):253-65. Epub 2014 Jan 28.

Department of Pharmaceutics and Medicinal Chemistry, Thomas J. Long School of Pharmacy and Health Sciences, University of the Pacific, Stockton, CA 95211, USA. Electronic address:

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March 2014

Pro-inflammatory action of MIF in acute myocardial infarction via activation of peripheral blood mononuclear cells.

PLoS One 2013 1;8(10):e76206. Epub 2013 Oct 1.

Baker IDI Heart and Diabetes Institute, Melbourne, Australia ; Department of Medicine, Central Clinical School, Monash University, Melbourne, Australia.

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July 2014

A cell-penetrating peptide suppresses the hypoxia inducible factor-1 function by binding to the helix-loop-helix domain of the aryl hydrocarbon receptor nuclear translocator.

Chem Biol Interact 2013 Apr 27;203(2):401-11. Epub 2013 Feb 27.

Department of Pharmaceutics and Medicinal Chemistry, Thomas J. Long School of Pharmacy and Health Sciences, University of the Pacific, Stockton, CA 95211, USA.

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April 2013

Microchimerism in the human brain: more questions than answers.

Chimerism 2013 Jan-Mar;4(1):32-3. Epub 2013 Jan 1.

Department of Biochemistry, University of Alberta, Edmonton, AB Canada.

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December 2013

Authors' reply.

Am J Cardiol 2013 Jan;111(2):303-4

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January 2013

Male microchimerism in the human female brain.

PLoS One 2012 26;7(9):e45592. Epub 2012 Sep 26.

Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.

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April 2013

p23 co-chaperone protects the aryl hydrocarbon receptor from degradation in mouse and human cell lines.

Biochem Pharmacol 2012 Sep 1;84(6):838-50. Epub 2012 Jul 1.

Department of Labour Physiology, Vietnam Military Medical University, Hadong, Hanoi, Viet Nam.

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September 2012

Decreased fibrocyte number is associated with atherosclerotic plaque instability in man.

Cardiovasc Res 2012 Jul 27;95(1):124-33. Epub 2012 Apr 27.

Baker IDI Heart and Diabetes Institute, 75 Commercial Road, Melbourne, VIC 3004, Australia.

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July 2012

A phase 1 dose-escalating study of pegylated recombinant human arginase 1 (Peg-rhArg1) in patients with advanced hepatocellular carcinoma.

Invest New Drugs 2013 Feb 17;31(1):99-107. Epub 2012 Mar 17.

Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Pokfulam, Hong Kong, China.

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February 2013

Suppression of the hypoxia inducible factor-1 function by redistributing the aryl hydrocarbon receptor nuclear translocator from nucleus to cytoplasm.

Cancer Lett 2012 Jul 2;320(1):111-21. Epub 2012 Feb 2.

Department of Pharmaceutics and Medicinal Chemistry, Thomas J. Long School of Pharmacy and Health Sciences, University of the Pacific, Stockton, CA 95211, USA.

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July 2012

Social benefit payments and acute injury among low-income mothers.

Open Med 2012 31;6(3):e101-8. Epub 2012 Jul 31.

Sunnybrook Health Sciences Centre, G-151, 2075 Bayview Avenue, Toronto, ON M4N 3M5, Canada.

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February 2014

Vascular stiffness and aging in HIV.

Sex Health 2011 Dec;8(4):474-84

Department of Cardiovascular Medicine, the Alfred Hospital, Melbourne, Vic. 3004, Australia.

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December 2011

Nonobese diabetic natural killer cells: a barrier to allogeneic chimerism that can be reduced by rapamycin.

Transplantation 2011 Nov;92(9):977-84

Department of Surgery, University of Alberta, Edmonton, Alberta, Canada.

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November 2011

Management of the no-reflow phenomenon.

Pharmacol Ther 2011 Oct 12;132(1):72-85. Epub 2011 Jun 12.

Department of Cardiovascular Medicine, the Alfred Hospital, Melbourne, Australia.

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October 2011

GULP1 is a novel APP-interacting protein that alters APP processing.

Biochem J 2011 Jun;436(3):631-9

Biochemistry Programme, School of Life Sciences, the Chinese University of Hong Kong, Shatin, NT, Hong Kong SAR.

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June 2011

Quality control activities associated with registries in interventional cardiology and surgery.

Heart Lung Circ 2011 Mar 1;20(3):180-6. Epub 2011 Feb 1.

Centre of Cardiovascular Research & Education in Therapeutics, Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Victoria, Australia.

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March 2011

Identification of cyclophilin-40-interacting proteins reveals potential cellular function of cyclophilin-40.

Anal Biochem 2011 Mar 10;410(2):257-65. Epub 2010 Dec 10.

Department of Pharmaceutics and Medicinal Chemistry, Thomas J. Long School of Pharmacy and Health Sciences, University of the Pacific, Stockton, CA 95211, USA.

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March 2011