Publications by authors named "William C Pomerantz"

54Publications

Quantifying the Selectivity of Protein-Protein and Small Molecule Interactions with Fluorinated Tandem Bromodomain Reader Proteins.

ACS Chem Biol 2020 11 3;15(11):3038-3049. Epub 2020 Nov 3.

Department of Chemistry, University of Minnesota, 207 Pleasant St. SE, Minneapolis, Minnesota 55455, United States.

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http://dx.doi.org/10.1021/acschembio.0c00720DOI Listing
November 2020

Selective N-Terminal BET Bromodomain Inhibitors by Targeting Non-Conserved Residues and Structured Water Displacement*.

Angew Chem Int Ed Engl 2020 Sep 24. Epub 2020 Sep 24.

Department of Chemistry, University of Minnesota-Twin Cities, 207 Pleasant St. SE, Minneapolis, MN, 55455, USA.

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http://dx.doi.org/10.1002/anie.202008625DOI Listing
September 2020

New inhibitors for the BPTF bromodomain enabled by structural biology and biophysical assay development.

Org Biomol Chem 2020 Jul;18(27):5174-5182

Department of Chemistry, University of Minnesota, 207 Pleasant St. SE, Minneapolis, Minnesota 55455, USA.

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http://dx.doi.org/10.1039/d0ob00506aDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7393680PMC
July 2020

NMR Analyses of Acetylated H2A.Z Isoforms Identify Differential Binding Interactions with the Bromodomain of the NURF Nucleosome Remodeling Complex.

Biochemistry 2020 May 11;59(20):1871-1880. Epub 2020 May 11.

Department of Chemistry, University of Minnesota, 207 Pleasant Street Southeast, Minneapolis, Minnesota 55455, United States.

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http://dx.doi.org/10.1021/acs.biochem.0c00159DOI Listing
May 2020

Efficient Synthesis of 1,4-Thiazepanones and 1,4-Thiazepanes as 3D Fragments for Screening Libraries.

Org Lett 2020 05 29;22(10):3946-3950. Epub 2020 Apr 29.

Department of Chemistry, University of Minnesota, Minneapolis, Minnesota 55455, United States.

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http://dx.doi.org/10.1021/acs.orglett.0c01230DOI Listing
May 2020

Multidimensional Nanoparticle Characterization through Ion Mobility-Mass Spectrometry.

Anal Chem 2020 02 21;92(3):2503-2510. Epub 2020 Jan 21.

Department of Mechanical Engineering , University of Minnesota , Minneapolis , Minnesota 55455 , United States.

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http://dx.doi.org/10.1021/acs.analchem.9b04012DOI Listing
February 2020

Evaluating the Advantages of Using 3D-Enriched Fragments for Targeting BET Bromodomains.

ACS Med Chem Lett 2019 Dec 22;10(12):1648-1654. Epub 2019 Nov 22.

Department of Chemistry, University of Minnesota, Minneapolis, Minnesota 55455, United States.

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http://dx.doi.org/10.1021/acsmedchemlett.9b00414DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6912871PMC
December 2019

2-Fluorotyrosine is a valuable but understudied amino acid for protein-observed F NMR.

J Biomol NMR 2020 Jan 23;74(1):61-69. Epub 2019 Nov 23.

Department of Chemistry, University of Minnesota, 207 Pleasant St. SE, Minneapolis, MN, 55455, USA.

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http://dx.doi.org/10.1007/s10858-019-00290-0DOI Listing
January 2020

SAR by (Protein-Observed) F NMR.

Acc Chem Res 2019 12 13;52(12):3407-3418. Epub 2019 Nov 13.

Department of Medicinal Chemistry , University of Minnesota , 2231 6th St. SE , Minneapolis , Minnesota 55455 , United States.

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http://dx.doi.org/10.1021/acs.accounts.9b00377DOI Listing
December 2019

Systematically Mitigating the p38α Activity of Triazole-based BET Inhibitors.

ACS Med Chem Lett 2019 Sep 2;10(9):1296-1301. Epub 2019 Aug 2.

Department of Chemistry, University of Minnesota Twin Cities, Minneapolis, Minnesota 55455, United States.

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http://dx.doi.org/10.1021/acsmedchemlett.9b00227DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6746085PMC
September 2019

Design, Synthesis, and Characterization of a Fluorescence Polarization Pan-BET Bromodomain Probe.

ACS Med Chem Lett 2018 Dec 31;9(12):1223-1229. Epub 2018 Oct 31.

Department of Medicinal Chemistry and Institute for Therapeutics Discovery & Development, College of Pharmacy, University of Minnesota, 717 Delaware Street SE, Minneapolis, Minnesota 55414, United States.

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http://pubs.acs.org/doi/10.1021/acsmedchemlett.8b00380
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http://dx.doi.org/10.1021/acsmedchemlett.8b00380DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6295860PMC
December 2018

Dual Labeling of the CBP/p300 KIX Domain for F NMR Leads to Identification of a New Small-Molecule Binding Site.

Chembiochem 2018 05 6;19(9):963-969. Epub 2018 Apr 6.

Department of Chemistry, University of Minnesota, 207 Pleasant Street, SE, Minneapolis, MN, 55455, USA.

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http://dx.doi.org/10.1002/cbic.201700686DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6251716PMC
May 2018

Specific Acetylation Patterns of H2A.Z Form Transient Interactions with the BPTF Bromodomain.

Biochemistry 2017 09 23;56(35):4607-4615. Epub 2017 Aug 23.

Department of Chemistry, University of Minnesota , 207 Pleasant Street Southeast, Minneapolis, Minnesota 55455, United States.

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http://dx.doi.org/10.1021/acs.biochem.7b00648DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5779092PMC
September 2017

Tuning Sulfur Oxidation States on Thioether-Bridged Peptide Macrocycles for Modulation of Protein Interactions.

Chembiochem 2017 09 7;18(18):1836-1844. Epub 2017 Aug 7.

Department of Chemistry, University of Minnesota, 207 Pleasant St SE, Minneapolis, MN, 55455, USA.

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http://dx.doi.org/10.1002/cbic.201700222DOI Listing
September 2017

BPTF Maintains Chromatin Accessibility and the Self-Renewal Capacity of Mammary Gland Stem Cells.

Stem Cell Reports 2017 07 1;9(1):23-31. Epub 2017 Jun 1.

Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, NY 11724, USA. Electronic address:

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http://dx.doi.org/10.1016/j.stemcr.2017.04.031DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5783326PMC
July 2017

Oxygen Sensing with Perfluorocarbon-Loaded Ultraporous Mesostructured Silica Nanoparticles.

ACS Nano 2017 06 22;11(6):5623-5632. Epub 2017 May 22.

Department of Chemistry, §Department of Chemical Engineering & Material Science, and ‡Center for Magnetic Resonance Research, University of Minnesota , Minneapolis, Minnesota 55455, United States.

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http://dx.doi.org/10.1021/acsnano.7b01006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5515277PMC
June 2017

Synthesis of Intrinsically Disordered Fluorinated Peptides for Modular Design of High-Signal F MRI Agents.

Angew Chem Int Ed Engl 2017 06 4;56(23):6440-6444. Epub 2017 May 4.

Department of Chemistry, University of Minnesota - Twin Cities, 207 Pleasant St. SE, Minneapolis, MN, 55455, USA.

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http://doi.wiley.com/10.1002/anie.201700426
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http://dx.doi.org/10.1002/anie.201700426DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5493043PMC
June 2017

Protein-Observed Fluorine NMR Is a Complementary Ligand Discovery Method to H CPMG Ligand-Observed NMR.

ACS Chem Biol 2016 11 5;11(11):3154-3164. Epub 2016 Oct 5.

Department of Chemistry, University of Minnesota , Minneapolis, Minnesota 55455, United States.

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http://dx.doi.org/10.1021/acschembio.6b00730DOI Listing
November 2016

Protein-observed (19)F-NMR for fragment screening, affinity quantification and druggability assessment.

Nat Protoc 2016 08 14;11(8):1414-27. Epub 2016 Jul 14.

Department of Chemistry, University of Minnesota, Minneapolis, Minnesota, USA.

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http://dx.doi.org/10.1038/nprot.2016.079DOI Listing
August 2016

Prediction of (19)F NMR Chemical Shifts in Labeled Proteins: Computational Protocol and Case Study.

Mol Pharm 2016 07 2;13(7):2376-86. Epub 2016 Jun 2.

Department of Chemistry, Chemical Theory Center, and Supercomputing Institute, University of Minnesota , 207 Pleasant Street SE, Minneapolis, Minnesota 55455, United States.

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http://dx.doi.org/10.1021/acs.molpharmaceut.6b00137DOI Listing
July 2016

Paramagnetic relaxation enhancement for protein-observed F NMR as an enabling approach for efficient fragment screening.

RSC Adv 2016 29;6(98):95715-95721. Epub 2016 Sep 29.

Department of Chemistry, University of Minnesota, 207 Pleasant St. SE, Minneapolis, MN 55455, United States.

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http://dx.doi.org/10.1039/C6RA21226CDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5421645PMC
September 2016

Protein-Observed Fluorine NMR: A Bioorthogonal Approach for Small Molecule Discovery.

J Med Chem 2016 06 14;59(11):5158-71. Epub 2015 Dec 14.

Department of Chemistry, University of Minnesota , 207 Pleasant Street SE, Minneapolis, Minnesota 55455, United States.

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http://dx.doi.org/10.1021/acs.jmedchem.5b01447DOI Listing
June 2016

Dual Screening of BPTF and Brd4 Using Protein-Observed Fluorine NMR Uncovers New Bromodomain Probe Molecules.

ACS Chem Biol 2015 Oct 28;10(10):2246-56. Epub 2015 Jul 28.

Department of Chemistry, University of Minnesota , 207 Pleasant St. SE, Minneapolis, Minnesota 55455, United States.

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http://dx.doi.org/10.1021/acschembio.5b00483DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4858447PMC
October 2015

Fragment screening and druggability assessment for the CBP/p300 KIX domain through protein-observed 19F NMR spectroscopy.

Angew Chem Int Ed Engl 2015 Mar 4;54(12):3735-9. Epub 2015 Feb 4.

Department of Chemistry, University of Minnesota, 207 Pleasant St. SE, Twin Cities (USA).

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http://dx.doi.org/10.1002/anie.201411658DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4423596PMC
March 2015

Fluorinated aromatic amino acids are sensitive 19F NMR probes for bromodomain-ligand interactions.

ACS Chem Biol 2014 Dec 27;9(12):2755-60. Epub 2014 Oct 27.

Department of Chemistry, University of Minnesota , 207 Pleasant St. SE, Minneapolis, Minnesota 55455, United States.

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http://dx.doi.org/10.1021/cb5007344DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4273984PMC
December 2014

FP Tethering: a screening technique to rapidly identify compounds that disrupt protein-protein interactions.

Medchemcomm 2014 Mar;5:370-375

Department of Chemistry, University of Michigan, Ann Arbor, Michigan 48109, United States ; Life Sciences Institute, University of Michigan, Ann Arbor, Michigan 48109, United States ; Program in Chemical Biology, University of Michigan, Ann Arbor, Michigan 48109, United States.

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http://dx.doi.org/10.1039/C3MD00356FDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4005387PMC
March 2014

Ordering a dynamic protein via a small-molecule stabilizer.

J Am Chem Soc 2013 Mar 22;135(9):3363-6. Epub 2013 Feb 22.

Program in Chemical Biology, University of Michigan, Ann Arbor, Michigan 48109, United States.

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http://dx.doi.org/10.1021/ja3122334DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3607081PMC
March 2013

Lyotropic liquid crystals formed from ACHC-rich β-peptides.

J Am Chem Soc 2011 Aug 4;133(34):13604-13. Epub 2011 Aug 4.

Department of Chemistry, University of Wisconsin-Madison, 1101 University Avenue, Madison, Wisconsin 53706, United States.

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http://dx.doi.org/10.1021/ja204874hDOI Listing
August 2011

Lyotropic liquid crystalline phases from helical β-peptides as alignment media.

Chem Commun (Camb) 2011 Jan 25;47(1):502-4. Epub 2010 Oct 25.

Clemens Schöpf Institut für Organische Chemie und Biochemie, Technische Universität Darmstadt, Petersenstr. 22, 64287 Darmstadt, Germany.

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http://dx.doi.org/10.1039/c0cc02123gDOI Listing
January 2011

Transcriptional tools: Small molecules for modulating CBP KIX-dependent transcriptional activators.

Biopolymers 2011 Jan;95(1):17-23

Department of Medicinal Chemistry, University of Michigan, Ann Arbor, MI 48109, USA.

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http://dx.doi.org/10.1002/bip.21548DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3535496PMC
January 2011

In situ monitoring of backbone thioester exchange by 19F NMR.

Chembiochem 2009 Sep;10(13):2177-81

Department of Chemistry, University of Wisconsin-Madison, 1101 University Avenue, Madison, Wisconsin 53706, USA.

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http://dx.doi.org/10.1002/cbic.200900380DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2874940PMC
September 2009

Preclinical development of a bifunctional cancer cell homing, PKCepsilon inhibitory peptide for the treatment of head and neck cancer.

Cancer Res 2009 Jul 30;69(14):5829-34. Epub 2009 Jun 30.

Department of Internal Medicine, Division of Hematology and Oncology, University of Michigan Medical School, Ann Arbor, Michigan, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-08-3465DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2757013PMC
July 2009

Effect of sequence and structural properties on 14-helical beta-peptide activity against Candida albicans planktonic cells and biofilms.

ACS Chem Biol 2009 Jul;4(7):567-79

Department of Chemical & Biological Engineering, University of Wisconsin-Madison, Madison, WI 53706, USA.

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http://dx.doi.org/10.1021/cb900093rDOI Listing
July 2009

A rationally designed aldolase foldamer.

Angew Chem Int Ed Engl 2009 ;48(5):922-5

Laboratorium für Organische Chemie, ETH Zürich, Hönggerberg HCI F339, 8093 Zürich, Switzerland.

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http://doi.wiley.com/10.1002/anie.200804996
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http://dx.doi.org/10.1002/anie.200804996DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2843390PMC
February 2009

Characterization of nanofibers formed by self-assembly of beta-peptide oligomers using small angle x-ray scattering.

J Chem Phys 2008 Sep;129(9):095103

Department of Chemical and Biological Engineering, University of Wisconsin-Madison, 1415 Engineering Drive, Madison, Wisconsin 53706-1322, USA.

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http://dx.doi.org/10.1063/1.2955745DOI Listing
September 2008

Comparison of design strategies for promotion of beta-peptide 14-helix stability in water.

Chembiochem 2008 Sep;9(14):2254-9

Max Planck Institute of Molecular Physiology, Otto-Hahn Strasse 11, 44227 Dortmund, Germany.

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http://dx.doi.org/10.1002/cbic.200800355DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3551619PMC
September 2008

Distinctive circular dichroism signature for 14-helix-bundle formation by beta-peptides.

Org Lett 2008 May 9;10(9):1799-802. Epub 2008 Apr 9.

Department of Chemistry, University of Wisconsin, Madison, WI 53706, USA.

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http://dx.doi.org/10.1021/ol800622eDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2886586PMC
May 2008

Nanofibers and lyotropic liquid crystals from a class of self-assembling beta-peptides.

Angew Chem Int Ed Engl 2008 ;47(7):1241-4

Department of Chemistry, University of Wisconsin-Madison, 1101 University Avenue, Madison, WI 53706, USA.

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http://dx.doi.org/10.1002/anie.200704372DOI Listing
March 2008

Origins of the high 14-helix propensity of cyclohexyl-rigidified residues in beta-peptides.

Org Lett 2007 Apr 30;9(9):1801-4. Epub 2007 Mar 30.

Department of Chemistry, University of Wisconsin, Madison, Wisconsin 53706, USA.

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http://dx.doi.org/10.1021/ol070511rDOI Listing
April 2007

Antifungal activity from 14-helical beta-peptides.

J Am Chem Soc 2006 Oct;128(39):12630-1

Department of Chemical and Biological Engineering, University of Wisconsin-Madison, Madison, WI 53706, USA.

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http://pubs.acs.org/doi/abs/10.1021/ja064630y
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http://dx.doi.org/10.1021/ja064630yDOI Listing
October 2006

Lyotropic liquid crystals from designed helical beta-peptides.

J Am Chem Soc 2006 Jul;128(27):8730-1

Departments of Chemical and Biological Engineering and Chemistry, University of Wisconsin, Madison, Wisconsin 53706, USA.

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http://dx.doi.org/10.1021/ja062412zDOI Listing
July 2006