William C Nichols

William C Nichols

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William C Nichols

William C Nichols

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The EYA3 tyrosine phosphatase activity promotes pulmonary vascular remodeling in pulmonary arterial hypertension.

Nat Commun 2019 09 12;10(1):4143. Epub 2019 Sep 12.

Division of Developmental Biology, Cincinnati Children's Hospital Medical Center, Department of Pediatrics, University of Cincinnati College of Medicine, 3333 Burnet Avenue, Cincinnati, OH, 45229, USA.

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http://dx.doi.org/10.1038/s41467-019-12226-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6742632PMC
September 2019

United States Pulmonary Hypertension Scientific Registry (USPHSR): rationale, design, and clinical implications.

Pulm Circ 2019 Apr-Jun;9(2):2045894019851696

10 Division of Human Genetics, Cincinnati Children's Medical Center and Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA.

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http://dx.doi.org/10.1177/2045894019851696DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6540712PMC
May 2019

Genetic determinants of risk in pulmonary arterial hypertension: international genome-wide association studies and meta-analysis.

Authors:
Christopher J Rhodes Ken Batai Marta Bleda Matthias Haimel Laura Southgate Marine Germain Michael W Pauciulo Charaka Hadinnapola Jurjan Aman Barbara Girerd Amit Arora Jo Knight Ken B Hanscombe Jason H Karnes Marika Kaakinen Henning Gall Anna Ulrich Lars Harbaum Inês Cebola Jorge Ferrer Katie Lutz Emilia M Swietlik Ferhaan Ahmad Philippe Amouyel Stephen L Archer Rahul Argula Eric D Austin David Badesch Sahil Bakshi Christopher Barnett Raymond Benza Nitin Bhatt Harm J Bogaard Charles D Burger Murali Chakinala Colin Church John G Coghlan Robin Condliffe Paul A Corris Cesare Danesino Stéphanie Debette C Gregory Elliott Jean Elwing Melanie Eyries Terry Fortin Andre Franke Robert P Frantz Adaani Frost Joe G N Garcia Stefano Ghio Hossein-Ardeschir Ghofrani J Simon R Gibbs John Harley Hua He Nicholas S Hill Russel Hirsch Arjan C Houweling Luke S Howard Dunbar Ivy David G Kiely James Klinger Gabor Kovacs Tim Lahm Matthias Laudes Rajiv D Machado Robert V MacKenzie Ross Keith Marsolo Lisa J Martin Shahin Moledina David Montani Steven D Nathan Michael Newnham Andrea Olschewski Horst Olschewski Ronald J Oudiz Willem H Ouwehand Andrew J Peacock Joanna Pepke-Zaba Zia Rehman Ivan Robbins Dan M Roden Erika B Rosenzweig Ghulam Saydain Laura Scelsi Robert Schilz Werner Seeger Christian M Shaffer Robert W Simms Marc Simon Olivier Sitbon Jay Suntharalingam Haiyang Tang Alexander Y Tchourbanov Thenappan Thenappan Fernando Torres Mark R Toshner Carmen M Treacy Anton Vonk Noordegraaf Quinten Waisfisz Anna K Walsworth Robert E Walter John Wharton R James White Jeffrey Wilt Stephen J Wort Delphine Yung Allan Lawrie Marc Humbert Florent Soubrier David-Alexandre Trégouët Inga Prokopenko Richard Kittles Stefan Gräf William C Nichols Richard C Trembath Ankit A Desai Nicholas W Morrell Martin R Wilkins

Lancet Respir Med 2019 Mar 5;7(3):227-238. Epub 2018 Dec 5.

Department of Medicine, Imperial College London, London, UK. Electronic address:

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http://dx.doi.org/10.1016/S2213-2600(18)30409-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6391516PMC
March 2019

Exome Sequencing in Children With Pulmonary Arterial Hypertension Demonstrates Differences Compared With Adults.

Circ Genom Precis Med 2018 04;11(4):e001887

Department of Pediatrics (N.Z., C.W., L.M., U.K., E.B.R., W.K.C.), Herbert Irving Comprehensive Cancer Center (A.S., W.K.C.), and Department of Medicine (E.B.R., W.K.C.), Columbia University Medical Center, Department of Applied Physics and Applied Mathematics (H.Q.), Department of Systems Biology (N.Z., H.Q., Y.S.), and Department of Biomedical Informatics (Y.S.), Columbia University, New York, NY; Regeneron Genetics Center, Regeneron Pharmaceuticals, Tarrytown, NY (C.G.-J., A.K.K., J.G.R., J.D.O., A.B., F.D.); Department of Pediatric Cardiology, Children's Hospital Colorado, Denver (D.D.I.); Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, TN (E.D.A., R.H.); and Division of Human Genetics, Cincinnati Children's Hospital Medical Center and Department of Pediatrics, University of Cincinnati College of Medicine, OH (W.C.N., M.W.P., K.A.L.).

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http://dx.doi.org/10.1161/CIRCGEN.117.001887DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5896781PMC
April 2018

Racial and ethnic differences in pulmonary arterial hypertension.

Pulm Circ 2017 Oct-Dec;7(4):793-796. Epub 2017 Sep 15.

1 14640 Pulmonary, Allergy and Critical Care Division, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.

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http://dx.doi.org/10.1177/2045893217732213DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5703127PMC
September 2017

Pulmonary arterial hypertension: Specialists' knowledge, practices, and attitudes of genetic counseling and genetic testing in the USA.

Pulm Circ 2017 Apr-Jun;7(2):372-383. Epub 2017 Mar 27.

1 Division of Human Genetics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.

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http://dx.doi.org/10.1177/2045893217700156DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5467928PMC
March 2017

Chronic allergic inflammation causes vascular remodeling and pulmonary hypertension in BMPR2 hypomorph and wild-type mice.

PLoS One 2012 9;7(3):e32468. Epub 2012 Mar 9.

Division of Pulmonary Biology, Cincinnati Children's Hospital Medical Center, Department of Pediatrics, University of Cincinnati, Cincinnati, Ohio, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0032468PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3302893PMC
August 2012

Copy number variation in familial Parkinson disease.

PLoS One 2011 2;6(8):e20988. Epub 2011 Aug 2.

Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, Indiana, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0020988PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3149037PMC
December 2011

High levels of placenta growth factor in sickle cell disease promote pulmonary hypertension.

Blood 2010 Jul 24;116(1):109-12. Epub 2010 Mar 24.

Divison of Experimental Hematology & Cancer Biology, Cincinnati Children's Hospital Medical Center, 3333 Burnet Ave., Cincinnati, OH 45229-3039, USA.

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http://dx.doi.org/10.1182/blood-2009-09-244830DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2904575PMC
July 2010

The doctoral education of professional marriage and family therapists.

J Marital Fam Ther 2010 Jul;36(3):259-69

Florida State University, Tallahassee, Florida 32306-1491, USA.

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http://doi.wiley.com/10.1111/j.1752-0606.2009.00158.x
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http://dx.doi.org/10.1111/j.1752-0606.2009.00158.xDOI Listing
July 2010

Maternal inheritance and mitochondrial DNA variants in familial Parkinson's disease.

BMC Med Genet 2010 Apr 1;11:53. Epub 2010 Apr 1.

Department of Neurology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1186/1471-2350-11-53DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2858137PMC
April 2010

Multiple step pattern as a biomarker in Parkinson disease.

Parkinsonism Relat Disord 2009 Aug 10;15(7):506-10. Epub 2009 Feb 10.

Department of Ophthalmology, Indiana University School of Medicine, 702 Rotary Circle, Indianapolis, IN 46202-5251, USA.

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http://dx.doi.org/10.1016/j.parkreldis.2009.01.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2872983PMC
August 2009

Alpha-synuclein and familial Parkinson's disease.

Mov Disord 2009 Jun;24(8):1125-31

Department of Medical and Molecular Genetics, Indiana University Medical Center, Indianapolis, Indiana 46202, USA.

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http://dx.doi.org/10.1002/mds.22524DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3397145PMC
June 2009

Genomewide association study for susceptibility genes contributing to familial Parkinson disease.

Hum Genet 2009 Jan 6;124(6):593-605. Epub 2008 Nov 6.

Indiana University School of Medicine, Health Information and Translational Sciences Building, Indianapolis, IN 46202-3002, USA.

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http://dx.doi.org/10.1007/s00439-008-0582-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2627511PMC
January 2009

Clinical correlates of depressive symptoms in familial Parkinson's disease.

Mov Disord 2008 Nov;23(15):2216-23

Department of Medical and Molecular Genetics, Indiana University, Indianapolis, Indiana 46202, USA.

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http://dx.doi.org/10.1002/mds.22285DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2872794PMC
November 2008

Murine pulmonary response to chronic hypoxia is strain specific.

Exp Lung Res 2008 Aug;34(6):313-23

Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Health Sciences Center, Denver, Colorado, USA.

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http://dx.doi.org/10.1080/01902140802093204DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3769701PMC
August 2008

R1514Q substitution in Lrrk2 is not a pathogenic Parkinson's disease mutation.

Mov Disord 2007 Jan;22(2):254-7

Division of Human Genetics, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio 45229, USA.

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http://dx.doi.org/10.1002/mds.21233DOI Listing
January 2007

High frequency of BMPR2 exonic deletions/duplications in familial pulmonary arterial hypertension.

Am J Respir Crit Care Med 2006 Sep 25;174(5):590-8. Epub 2006 May 25.

Division of Medical Genetics, Vanderbilt University Medical University Medical Center, Nashville, Tennessee, USA.

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http://dx.doi.org/10.1164/rccm.200602-165OCDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2648061PMC
September 2006

Hearing impairment susceptibility in elderly men and the DFNA18 locus.

Arch Otolaryngol Head Neck Surg 2006 May;132(5):506-10

Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, USA.

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http://dx.doi.org/10.1001/archotol.132.5.506DOI Listing
May 2006

Presence of an APOE4 allele results in significantly earlier onset of Parkinson's disease and a higher risk with dementia.

Mov Disord 2006 Jan;21(1):45-9

Department of Medical and Molecular Genetics, Indiana University Medical Center, Indianapolis, Indiana, USA.

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http://dx.doi.org/10.1002/mds.20663DOI Listing
January 2006

Verification of self-report of zygosity determined via DNA testing in a subset of the NAS-NRC twin registry 40 years later.

Twin Res Hum Genet 2005 Aug;8(4):362-7

Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN 46202, USA.

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http://dx.doi.org/10.1375/1832427054936763DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1262657PMC
August 2005

Genetic screening for a single common LRRK2 mutation in familial Parkinson's disease.

Lancet 2005 Jan 29-Feb 4;365(9457):410-2

Division of Human Genetics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.

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http://dx.doi.org/10.1016/S0140-6736(05)17828-3DOI Listing
February 2005

Midkine is regulated by hypoxia and causes pulmonary vascular remodeling.

J Biol Chem 2004 Aug 14;279(35):37124-32. Epub 2004 Jun 14.

Divisions of Pulmonary Biology and Human Genetics, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, 3333 Burnet Avenue, Cincinnati, OH 45229-3039, USA.

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http://dx.doi.org/10.1074/jbc.M405254200DOI Listing
August 2004

Evaluation of the role of Nurr1 in a large sample of familial Parkinson's disease.

Mov Disord 2004 Jun;19(6):649-55

Division of Human Genetics, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio 45229, USA.

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http://dx.doi.org/10.1002/mds.20097DOI Listing
June 2004

Genome-wide scan for a healthy aging phenotype provides support for a locus near D4S1564 promoting healthy aging.

J Gerontol A Biol Sci Med Sci 2004 Mar;59(3):227-32

Department of Medical & Molecular Genetics, Indiana University School of Medicine, Indianapolis 46202-5251, USA.

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http://dx.doi.org/10.1093/gerona/59.3.b227DOI Listing
March 2004

Trends in family therapy supervision: the past 25 years and into the future.

J Marital Fam Ther 2004 Jan;30(1):61-9

Michigan State University, USA.

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http://dx.doi.org/10.1111/j.1752-0606.2004.tb01222.xDOI Listing
January 2004

Genome-wide linkage analysis and evidence of gene-by-gene interactions in a sample of 362 multiplex Parkinson disease families.

Hum Mol Genet 2003 Oct 12;12(20):2599-608. Epub 2003 Aug 12.

Indiana University School of Medicine, Department of Medical and Molecular Genetics (IB 130), 975 West Walnut Street, Indianapolis, IN 46202-5251, USA.

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http://dx.doi.org/10.1093/hmg/ddg270DOI Listing
October 2003

Role of dopamine transporter genotype and maternal prenatal smoking in childhood hyperactive-impulsive, inattentive, and oppositional behaviors.

J Pediatr 2003 Jul;143(1):104-10

Division of General and Community Pediatrics, and Children's Environmental Health Center, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio 45229-3039, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S002234760300208
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http://dx.doi.org/10.1016/S0022-3476(03)00208-7DOI Listing
July 2003

Significant linkage of Parkinson disease to chromosome 2q36-37.

Am J Hum Genet 2003 Apr 13;72(4):1053-7. Epub 2003 Mar 13.

Department of Medical and Molecular Genetics, Indiana University Medical Center, Indianapolis, IN 46202, USA.

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http://dx.doi.org/10.1086/374383DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1180337PMC
April 2003

Pulmonary veno-occlusive disease caused by an inherited mutation in bone morphogenetic protein receptor II.

Am J Respir Crit Care Med 2003 Mar 21;167(6):889-94. Epub 2002 Nov 21.

Division of Allergy, Pulmonary and Critical Care Medicine, Vanderbilt University Medical Center, T-1217 Medical Center North, Nashville, TN 37232-2650, USA.

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http://www.atsjournals.org/doi/abs/10.1164/rccm.200208-861OC
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http://dx.doi.org/10.1164/rccm.200208-861OCDOI Listing
March 2003

Reliability of reported age at onset for Parkinson's disease.

Mov Disord 2003 Mar;18(3):275-9

Department of Neurology, The Ohio State University, Columbus, Ohio, USA.

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http://dx.doi.org/10.1002/mds.10391DOI Listing
March 2003

Genome screen to identify susceptibility genes for Parkinson disease in a sample without parkin mutations.

Am J Hum Genet 2002 Jul 7;71(1):124-35. Epub 2002 Jun 7.

Department of Medical and Molecular Genetics, Indiana University Medical Center, Indianapolis 46202-5251, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S000292970760040
Publisher Site
http://dx.doi.org/10.1086/341282DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC384969PMC
July 2002