Publications by authors named "William C Hahn"

100Publications

Synthetic Lethal Interaction of SHOC2 Depletion with MEK Inhibition in RAS-Driven Cancers.

Cell Rep 2019 10;29(1):118-134.e8

Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Harvard Medical School, 25 Shattuck Street, Boston, MA 02115, USA; Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, 75 Francis Street, Boston, MA 02115, MA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2019.08.090DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6918830PMC
October 2019

A CRISPR Way to Identify Cancer Targets.

Authors:
William C Hahn

N Engl J Med 2019 Jun;380(25):2475-2477

From the Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, and the Broad Institute of Harvard and MIT, Cambridge - both in Massachusetts.

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http://dx.doi.org/10.1056/NEJMcibr1905048DOI Listing
June 2019

A Somatically Acquired Enhancer of the Androgen Receptor Is a Noncoding Driver in Advanced Prostate Cancer.

Cell 2018 07 14;174(2):422-432.e13. Epub 2018 Jun 14.

Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; The Eli and Edythe L. Broad Institute, Cambridge, MA 02142, USA; Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, MA 02215, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00928674183064
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http://dx.doi.org/10.1016/j.cell.2018.05.037DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6046260PMC
July 2018

Interrogation of Mammalian Protein Complex Structure, Function, and Membership Using Genome-Scale Fitness Screens.

Cell Syst 2018 05 16;6(5):555-568.e7. Epub 2018 May 16.

Dana-Farber Cancer Institute, 450 Brookline Avenue, Boston, MA 02215, USA; Broad Institute of Harvard and MIT, 415 Main Street, Cambridge, MA 02142, USA; Harvard Medical School, Boston, MA 02115, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S24054712183018
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http://dx.doi.org/10.1016/j.cels.2018.04.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6152908PMC
May 2018

Genomic Resistance Patterns to Second-Generation Androgen Blockade in Paired Tumor Biopsies of Metastatic Castration-Resistant Prostate Cancer.

JCO Precis Oncol 2017 11;1. Epub 2017 Dec 11.

, , , , , , , , and , Dana-Farber Cancer Institute; , , , and , Brigham and Women's Hospital; and , Beth Israel Deaconess Medical Center, Boston; , , , , , , , and , Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, MA; and , University of California San Diego, La Jolla, CA.

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http://dx.doi.org/10.1200/PO.17.00140DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7446377PMC
December 2017

Synthetic Lethal Vulnerabilities in -Mutant Cancers.

Cold Spring Harb Perspect Med 2018 08 1;8(8). Epub 2018 Aug 1.

Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts 02215.

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http://dx.doi.org/10.1101/cshperspect.a031518DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5990478PMC
August 2018

Defining a Cancer Dependency Map.

Cell 2017 Jul;170(3):564-576.e16

Broad Institute of Harvard and MIT, 415 Main Street, Cambridge, MA, USA; Dana-Farber Cancer Institute, 450 Brookline Avenue, Boston, MA, USA; Department of Medicine, Brigham and Women's Hospital, 75 Francis Street, Boston, MA, USA; Harvard Medical School, 25 Shattuck Street, Boston, MA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2017.06.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5667678PMC
July 2017

PRMT1-Mediated Translation Regulation Is a Crucial Vulnerability of Cancer.

Cancer Res 2017 09 27;77(17):4613-4625. Epub 2017 Jun 27.

Division of Hematology/Oncology, Boston Children's Hospital and Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Stem Cell Institute, Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1158/0008-5472.CAN-17-0216DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5581676PMC
September 2017

Complementary information derived from CRISPR Cas9 mediated gene deletion and suppression.

Nat Commun 2017 05 23;8:15403. Epub 2017 May 23.

Broad Institute of Harvard and MIT, 415 Main Street, Cambridge, Massachusetts 02142, USA.

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http://dx.doi.org/10.1038/ncomms15403DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5457492PMC
May 2017

Going beyond genetics to discover cancer targets.

Genome Biol 2017 05 22;18(1):95. Epub 2017 May 22.

Dana-Farber Cancer Institute and Harvard Medical School, Brookline Ave, Boston, MA, 02215, USA.

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http://dx.doi.org/10.1186/s13059-017-1238-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5439228PMC
May 2017

PARP3 is a promoter of chromosomal rearrangements and limits G4 DNA.

Nat Commun 2017 04 27;8:15110. Epub 2017 Apr 27.

Department of Medical Oncology, Dana-Farber Cancer Institute, 450 Brookline Avenue, Boston, Massachusetts 02215, USA.

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http://dx.doi.org/10.1038/ncomms15110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5414184PMC
April 2017

Functional Genomic Characterization of Cancer Genomes.

Cold Spring Harb Symp Quant Biol 2016 4;81:237-246. Epub 2016 Nov 4.

Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02215.

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http://dx.doi.org/10.1101/sqb.2016.81.031070DOI Listing
February 2018

Genetic and Proteomic Interrogation of Lower Confidence Candidate Genes Reveals Signaling Networks in β-Catenin-Active Cancers.

Cell Syst 2016 09;3(3):302-316.e4

Broad Institute of Harvard and MIT, 415 Main Street, Cambridge, MA 02142, USA; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, 450 Brookline Avenue, Boston, MA 02215, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cels.2016.09.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5455996PMC
September 2016

Tyrosine receptor kinase B is a drug target in astrocytomas.

Neuro Oncol 2017 01 10;19(1):22-30. Epub 2016 Jul 10.

Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts (J.N., S.X., V.L., Y.S., P.B., R.B., T.M.R., C.D.S., R.A.S., J.J.Z.); Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts (J.N., S.X., V.L., T.M.R., J.J.Z.); Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts (S.H.R., R.B., K.L.L., W.C.H.); Broad Institute, Boston, Massachusetts (P.B., R.B., W.C.H.); Department of Pathology, Brigham and Women's Hospital, Boston, Massachusetts (S.H.R., K.L.L.); Department of Pathology, Boston Children's Hospital, Boston, Massachusetts (K.L.L.)

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http://dx.doi.org/10.1093/neuonc/now139DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5193024PMC
January 2017

Genomic Copy Number Dictates a Gene-Independent Cell Response to CRISPR/Cas9 Targeting.

Cancer Discov 2016 08 3;6(8):914-29. Epub 2016 Jun 3.

Dana-Farber Cancer Institute, Boston, Massachusetts. Broad Institute of Harvard and MIT, Cambridge, Massachusetts. Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts. Harvard Medical School, Boston, Massachusetts. Center for Cancer Genome Discovery, Dana-Farber Cancer Institute, Boston, Massachusetts.

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http://dx.doi.org/10.1158/2159-8290.CD-16-0154DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4972686PMC
August 2016

Identification of an "Exceptional Responder" Cell Line to MEK1 Inhibition: Clinical Implications for MEK-Targeted Therapy.

Mol Cancer Res 2016 Feb 18;14(2):207-15. Epub 2015 Nov 18.

Broad Institute of Harvard and MIT, Cambridge, Massachusetts. Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts. Center for Cancer Genome Discovery, Dana-Farber Cancer Institute, Boston, Massachusetts. Department of Pathology, Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1158/1541-7786.MCR-15-0321DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4755909PMC
February 2016

Oncogenic Signaling Adaptor Proteins.

J Genet Genomics 2015 Oct 12;42(10):521-529. Epub 2015 Sep 12.

Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, MA 02142, USA; Center for Cancer Genome Discovery, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Department of Medicine, Brigham and Women's Hospital, Boston, MA 02215, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jgg.2015.09.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4643408PMC
October 2015

Correction for Hwang et al., Polyomavirus small T antigen interacts with yes-associated protein to regulate cell survival and differentiation.

J Virol 2015 Jul;89(13):6971

Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1128/JVI.00952-15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4468481PMC
July 2015

BreaKmer: detection of structural variation in targeted massively parallel sequencing data using kmers.

Nucleic Acids Res 2015 Feb 26;43(3):e19. Epub 2014 Nov 26.

Center for Cancer Genome Discovery and Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA 02215, USA Department of Pathology, Brigham and Women's Hospital, Boston, MA 02215, USA

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http://dx.doi.org/10.1093/nar/gku1211DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4330340PMC
February 2015

The Tyrosine Kinase Adaptor Protein FRS2 Is Oncogenic and Amplified in High-Grade Serous Ovarian Cancer.

Mol Cancer Res 2015 Mar 3;13(3):502-9. Epub 2014 Nov 3.

Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, Massachusetts. Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts. Center for Cancer Genome Discovery, Dana-Farber Cancer Institute, Boston, Massachusetts. Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts.

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http://dx.doi.org/10.1158/1541-7786.MCR-14-0407DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4369154PMC
March 2015

RNF43 is frequently mutated in colorectal and endometrial cancers.

Nat Genet 2014 Dec 26;46(12):1264-6. Epub 2014 Oct 26.

1] Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, USA. [2] Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA. [3] Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.

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http://dx.doi.org/10.1038/ng.3127DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4283570PMC
December 2014

Polyomavirus small T antigen interacts with yes-associated protein to regulate cell survival and differentiation.

J Virol 2014 Oct 13;88(20):12055-64. Epub 2014 Aug 13.

Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts, USA

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http://jvi.asm.org/content/88/20/12055.full.pdf
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http://jvi.asm.org/cgi/doi/10.1128/JVI.01399-14
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http://dx.doi.org/10.1128/JVI.01399-14DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4178709PMC
October 2014

Analysis of tumour- and stroma-supplied proteolytic networks reveals a brain-metastasis-promoting role for cathepsin S.

Nat Cell Biol 2014 Sep 3;16(9):876-88. Epub 2014 Aug 3.

1] Cancer Biology and Genetics Program, Memorial Sloan-Kettering Cancer Center, New York, New York 10065, USA [2] Brain Tumor Center, Memorial Sloan-Kettering Cancer Center, New York, New York 10065, USA [3] Metastasis Research Center, Memorial Sloan-Kettering Cancer Center, New York, New York 10065, USA.

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http://dx.doi.org/10.1038/ncb3011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4249762PMC
September 2014

KRAS and YAP1 converge to regulate EMT and tumor survival.

Cell 2014 Jul 19;158(1):171-84. Epub 2014 Jun 19.

Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA 02115, USA; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2014.06.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4110062PMC
July 2014

Analysis and comparison of somatic mutations in paired primary and recurrent epithelial ovarian cancer samples.

PLoS One 2014 17;9(6):e99451. Epub 2014 Jun 17.

Department of Pathology, University of Ulsan, ASAN Medical Center, Seoul, Korea; ASAN Center for Cancer Genome Discovery, ASAN Medical Center, Seoul, Korea.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0099451PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4060993PMC
February 2015

PP2A-mediated regulation of Ras signaling in G2 is essential for stable quiescence and normal G1 length.

Mol Cell 2014 Jun 22;54(6):932-45. Epub 2014 May 22.

Department of Genetics, Harvard Medical School, Boston, MA 02115, USA; Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2014.04.023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4118046PMC
June 2014

Requirement for CDK6 in MLL-rearranged acute myeloid leukemia.

Blood 2014 Jul 24;124(1):13-23. Epub 2014 Apr 24.

Department of Translational Oncology, National Center for Tumor Diseases and German Cancer Research Center, Heidelberg, Germany; German Consortium for Translational Cancer Research, Heidelberg, Germany;

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http://dx.doi.org/10.1182/blood-2014-02-558114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4190617PMC
July 2014