William B Isaacs

William B Isaacs

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William B Isaacs

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Inherited risk assessment of prostate cancer: it takes three to do it right.

Prostate Cancer Prostatic Dis 2019 Aug 15. Epub 2019 Aug 15.

Program for Personalized Cancer Care, NorthShore University HealthSystem, Evanston, IL, USA.

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http://dx.doi.org/10.1038/s41391-019-0165-yDOI Listing
August 2019

Concept and benchmarks for assessing narrow-sense validity of genetic risk score values.

Prostate 2019 Jul 29;79(10):1099-1105. Epub 2019 Apr 29.

Program for Personalized Cancer Care, NorthShore University HealthSystem, Evanston, Illinois.

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http://dx.doi.org/10.1002/pros.23821DOI Listing
July 2019

Mannose Receptor-positive Macrophage Infiltration Correlates with Prostate Cancer Onset and Metastatic Castration-resistant Disease.

Eur Urol Oncol 2019 Jul 19;2(4):429-436. Epub 2018 Oct 19.

Department of Oncology, Johns Hopkins School of Medicine and The Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD, USA; Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

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http://dx.doi.org/10.1016/j.euo.2018.09.014DOI Listing
July 2019

Germline Mutations in ATM and BRCA1/2 Are Associated with Grade Reclassification in Men on Active Surveillance for Prostate Cancer.

Eur Urol 2019 05 8;75(5):743-749. Epub 2018 Oct 8.

Program for Personalized Cancer Care, North Shore University Health System, Evanston, IL, USA; Fudan Institute of Urology, Huashan Hospital, Fudan University, Shanghai, China; State Key Laboratory of Genetic Engineering, School of Life Science, Fudan University, Shanghai, China.

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https://linkinghub.elsevier.com/retrieve/pii/S03022838183068
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http://dx.doi.org/10.1016/j.eururo.2018.09.021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6699614PMC
May 2019

HOXB13 interaction with MEIS1 modifies proliferation and gene expression in prostate cancer.

Prostate 2019 Mar 17;79(4):414-424. Epub 2018 Dec 17.

Brady Urological Institute, Johns Hopkins University, School of Medicine, Baltimore, Maryland.

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http://dx.doi.org/10.1002/pros.23747DOI Listing
March 2019

Dynamics expression of during embryonic early development of .

Cell Biosci 2019 8;9. Epub 2019 Jan 8.

1National Engineering Laboratory for Resource Development of Endangered Crude Drugs in Northwest of China/CGDB, Shaanxi Normal University College of Life Sciences, Xi'an, 710062 China.

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https://cellandbioscience.biomedcentral.com/articles/10.1186
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http://dx.doi.org/10.1186/s13578-019-0270-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6325743PMC
January 2019

Current progress and questions in germline genetics of prostate cancer.

Asian J Urol 2019 Jan 2;6(1):3-9. Epub 2018 Nov 2.

North Shore University Health System, Research Institute, Evanston, IL, USA.

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http://dx.doi.org/10.1016/j.ajur.2018.10.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6363602PMC
January 2019

Germline mutations in PPFIBP2 are associated with lethal prostate cancer.

Prostate 2018 12 24;78(16):1222-1228. Epub 2018 Jul 24.

Department of Urology and the James Buchanan Brady Urologic Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland.

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http://dx.doi.org/10.1002/pros.23697DOI Listing
December 2018

Germline DNA-repair Gene Mutations and Outcomes in Men with Metastatic Castration-resistant Prostate Cancer Receiving First-line Abiraterone and Enzalutamide.

Eur Urol 2018 08 10;74(2):218-225. Epub 2018 Feb 10.

Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD, USA; Department of Urology, Johns Hopkins University School of Medicine, Baltimore, MD, USA. Electronic address:

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http://dx.doi.org/10.1016/j.eururo.2018.01.035DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6045965PMC
August 2018

Differences in inherited risk among relatives of hereditary prostate cancer patients using genetic risk score.

Prostate 2018 Jun 19. Epub 2018 Jun 19.

Division of Urology, John and Carol Walter for Urologic Health, NorthShore University HealthSystem, Evanston, Illinois.

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http://dx.doi.org/10.1002/pros.23664DOI Listing
June 2018

Calcium signaling: an underlying link between cardiac disease and carcinogenesis.

Cell Biosci 2018 8;8:39. Epub 2018 Jun 8.

4Ohio State University College of Medicine, Columbus, OH 43210 USA.

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http://dx.doi.org/10.1186/s13578-018-0236-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5992721PMC
June 2018

Genetic factors influencing prostate cancer risk in Norwegian men.

Prostate 2018 02 27;78(3):186-192. Epub 2017 Nov 27.

Brady Urological Institute, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins Medical Institutions, Baltimore, Maryland.

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http://dx.doi.org/10.1002/pros.23453DOI Listing
February 2018

Role of Genetic Testing for Inherited Prostate Cancer Risk: Philadelphia Prostate Cancer Consensus Conference 2017.

J Clin Oncol 2018 02 13;36(4):414-424. Epub 2017 Dec 13.

Veda N. Giri, Karen E. Knudsen, William K. Kelly, Robert B. Den, Adam P. Dicker, Jean Hoffman-Censits, Mark D. Hurwitz, Colette Hyatt, Grace Lu-Yao, Mark J. Mann, James R. Mark, Peter A. McCue, Ronald E. Myers, Stephen C. Peiper, Edouard J. Trabulsi, and Leonard G. Gomella, Jefferson Sidney Kimmel Cancer Center; Justin E. Bekelman, University of Pennsylvania Perelman School of Medicine; S. Bruce Malkowicz, University of Pennsylvania; Elias Obeid and Robert Uzzo, Fox Chase Cancer Center; Gordon F. Schwartz, Foundation for Breast and Prostate Health, Philadelphia; Mark S. Shahin, Hanjani Institute for Gynecologic Oncology, Abington Hospital-Jefferson Health, Abington, PA; Wassim Abida, Philip Kantoff, and Mark E. Robson, Memorial Sloan Kettering Cancer Center; Mitchell C. Benson, Columbia University, New York, NY; Gerald L. Andriole, Washington University School of Medicine, St Louis, MO; Chris H. Bangma, Erasmus Medical Center, Rotterdam, the Netherlands; Amie Blanco, and Matthew Cooperberg, University of California, San Francisco Helen Diller Family Comprehensive Cancer Center, San Francisco; Christopher J. Kane, University of California San Diego, San Diego; Howard Sandler, Cedars-Sinai Medical Center, Los Angeles; Howard R. Soule, Prostate Cancer Foundation, Santa Monica, CA; Arthur Burnett, William B. Isaacs, Christian P. Pavlovich, and Patrick C. Walsh, Johns Hopkins Medical Institutions, Baltimore; Peter A. Pinto and Carol J. Weil, National Cancer Institute, Bethesda, MD; William J. Catalona and Edward Schaeffer, Northwestern University Feinberg School of Medicine; Scott Eggener, Sarah M. Nielsen, and Donald J. Vander Griend, University of Chicago, Chicago, IL; Kathleen A. Cooney, University of Utah School of Medicine, Salt Lake City, UT; David E. Crawford, University of Colorado, Aurora; Lawrence I. Karsh, The Urology Center of Colorado, Denver; Wendy Poage, Prostate Conditions Education Council, Elizabeth, CO; Neil Fleshner, University of Toronto Princess Margaret Cancer Centre, Toronto, Ontario, Canada; Matthew L. Freedman, Kevin R. Loughlin, and Timothy R. Rebbeck, Dana Farber Cancer Institute, and Harvard TH Chan School of Public Health, Boston, MA; Freddie C. Hamdy, University of Oxford, Oxford, England; R. Jeffrey Karnes, Mayo Clinic, Rochester, MN; Eric A. Klein, Cleveland Clinic, Cleveland; Robert Pilarski, The Ohio State University, Columbus, OH; Daniel W. Lin, University of Washington, Seattle, WA; Martin M. Miner, Brown University, Providence, RI; Todd Morgan and Scott A. Tomlins, University of Michigan, Ann Arbor; Matt T. Rosenberg, Mid-Michigan Health Center, Jackson, MI; Judd W. Moul, Duke University, Duke Cancer Institute, Durham, NC; David F. Penson, Vanderbilt University Medical Center, Nashville, TN; Daniel Petrylak and Brian Shuch, Yale University, New Haven, CT; Curtis A. Pettaway, The University of Texas MD Anderson Cancer Center, Houston; Ganesh V. Raj, University of Texas Southwestern Medical Center at Dallas, Dallas, TX; Oliver Sartor, Tulane University Medical School, New Orleans, LA; Neal D. Shore, Atlantic Urology Clinics/Carolina Urologic Research Center, Myrtle Beach, SC; and Richard Wender, American Cancer Society, Atlanta, GA.

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http://dx.doi.org/10.1200/JCO.2017.74.1173DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6075860PMC
February 2018

The expression of AURKA is androgen regulated in castration-resistant prostate cancer.

Sci Rep 2017 12 21;7(1):17978. Epub 2017 Dec 21.

BioMediTech Institute, Faculty of Medicine and Life Sciences, University of Tampere, Fimlab Laboratories, Tampere University Hospital, Tampere, Finland.

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http://dx.doi.org/10.1038/s41598-017-18210-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5740165PMC
December 2017

Two Novel Susceptibility Loci for Prostate Cancer in Men of African Ancestry.

J Natl Cancer Inst 2017 08;109(8)

Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA.

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http://dx.doi.org/10.1093/jnci/djx084DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5448553PMC
August 2017

What Do Myeloma, Breast Cancer, and Prostate Cancer Have in Common?

Authors:
William B Isaacs

Eur Urol 2017 02 3;71(2):166-167. Epub 2016 Sep 3.

Brady Urological Institute, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA. Electronic address:

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http://dx.doi.org/10.1016/j.eururo.2016.08.058DOI Listing
February 2017

Rare Variation in TET2 Is Associated with Clinically Relevant Prostate Carcinoma in African Americans.

Cancer Epidemiol Biomarkers Prev 2016 11 2;25(11):1456-1463. Epub 2016 Aug 2.

Division of Urology, Department of Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1158/1055-9965.EPI-16-0373DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5093030PMC
November 2016

DNA-Repair Gene Mutations in Metastatic Prostate Cancer.

N Engl J Med 2016 11;375(18):1802-1803

Johns Hopkins School of Medicine, Baltimore, MD.

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http://dx.doi.org/10.1056/NEJMc1611137DOI Listing
November 2016

Prostate Cancer Susceptibility in Men of African Ancestry at 8q24.

J Natl Cancer Inst 2016 Jul 27;108(7). Epub 2016 Jan 27.

Affiliations of authors: Department of Preventive Medicine (YH, KAR, DJH, SAI, FRS, GC, LCP, XS, GAC, DOS, DVC, BEH, CAH) and Department of Urology (GAC), Keck School of Medicine, and Norris Comprehensive Cancer Center (SAI, FRS, GC, GAC, DOS, DVC, BEH, CAH), University of Southern California , Los Angeles, CA ; University of Arizona College of Medicine and University of Arizona Cancer Center , Tucson, AZ (RAK); Department of Epidemiology (SSS) and Department of Urology (CAP), University of Texas M. D. Anderson Cancer Center , Houston, TX ; Department of Public Health Sciences (BAR) and Department of Public Health Sciences (CND), Henry Ford Hospital , Detroit, MI ; Department of Preventive Medicine, Stony Brook University , Stony Brook, NY (BN, MCL, SYW, AJMH); James Buchanan Brady Urological Institute, Johns Hopkins Hospital and Medical Institution , Baltimore, MD (WBI); Division of Public Health Sciences (JLS, SK) and SWOG Statistical Center (PJG), Fred Hutchinson Cancer Research Center , Seattle, WA ; Department of Epidemiology, School of Public Health, University of Washington , Seattle, WA (JLS); Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt University School of Medicine , Nashville, TN (WZ, WJB); Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health , Bethesda, MD (SIB, ZW, MBC, SJC); Cancer Genomics Research Laboratory, NCI-DCEG, SAIC-Frederick Inc. , Frederick, MD (ZW); Program for Personalized Cancer Care and Department of Surgery, NorthShore University HealthSystem , Evanston, IL (JX); Department of Genetics (NR, DR, AT, AA, DQ, SM) and Howard Hughes Medical Institute (DR, SM), Harvard Medical School, Harvard University , Boston, MA ; Broad Institute of MIT and Harvard , Cambridge, MA (NR, DR, AT, AA, DQ, SM); Department of Pathology and Laboratory Medicine and Department of Human Genetics, David Geffen School of Medicine, University of California , Los Angeles, Los Angeles, CA (BP); Howard Hughes Medical Institute, Department of Medicine, School of Medicine, University of California , San Diego, San Diego, CA (DN, MGR, RSJ); Epidemiology Research Program, American Cancer Society , Atlanta, GA (SMG, VLS); Korle Bu Teaching Hospital , Accra , Ghana (EDY, YT, RBB, AAA, ET); University of Ghana Medical School , Accra , Ghana (EDY, YT, RBB, AAA, ET); Westat , Rockville, MD (AT, SN); School of Public Health, University of California , Berkeley, Berkeley, CA (APC); Cancer Prevention Institute of California , Fremont, CA (EMJ, AWH, LC); Stanford University School of Medicine and Stanford Cancer Institute , Palo Alto, CA (EMJ, AWH, LC); Department of Urology, Northwestern University , Chicago, IL (ABM); Department of Epidemiology, Harvard School of Public Health , Boston, MA (LBS, WJB); The Translational Genomics Research Institute , Phoenix, AZ (JC); Chronic Disease Research Centre and Faculty of Medical Sciences, University of the West Indies , Bridgetown, Barbados (AJMH); Glickman Urological & Kidney Institute, Cleveland Clinic , Cleveland, OH (EAK); Center for Cancer Genomics, Wake Forest School of Medicine , Winston-Salem, NC (SLZ); Department of Epidemiology and Biostatistics and Institute for Human Genetics, University of California , San Francisco, San Francisco, CA (JSW); School of Public Health, Makerere University College of Health Sciences , Kampala, Uganda (AL, SW); Uro Care , Kampala , Uganda (SW).

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http://dx.doi.org/10.1093/jnci/djv431DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4948565PMC
July 2016

Screening for familial and hereditary prostate cancer.

Int J Cancer 2016 Jun 5;138(11):2579-91. Epub 2016 Feb 5.

Department of Urology, Wayne State University, Karmanos Cancer Institute, University Health Center 7-C, Detroit, MI.

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http://dx.doi.org/10.1002/ijc.29949DOI Listing
June 2016

Integrated clinical, whole-genome, and transcriptome analysis of multisampled lethal metastatic prostate cancer.

Cold Spring Harb Mol Case Stud 2016 May;2(3):a000752

Prostate Cancer Research Center, Institute of Biosciences and Medical Technology, BioMediTech, University of Tampere and Fimlab Laboratories, Tampere University Hospital, FI-33014 Tampere, Finland;

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http://dx.doi.org/10.1101/mcs.a000752DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4853517PMC
May 2016

Genetic variants in cell cycle control pathway confer susceptibility to aggressive prostate carcinoma.

Prostate 2016 Apr 28;76(5):479-90. Epub 2015 Dec 28.

Departments of Genetics, Washington University School of Medicine, St. Louis, Missouri.

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http://dx.doi.org/10.1002/pros.23139DOI Listing
April 2016

Atlas of prostate cancer heritability in European and African-American men pinpoints tissue-specific regulation.

Authors:
Alexander Gusev Huwenbo Shi Gleb Kichaev Mark Pomerantz Fugen Li Henry W Long Sue A Ingles Rick A Kittles Sara S Strom Benjamin A Rybicki Barbara Nemesure William B Isaacs Wei Zheng Curtis A Pettaway Edward D Yeboah Yao Tettey Richard B Biritwum Andrew A Adjei Evelyn Tay Ann Truelove Shelley Niwa Anand P Chokkalingam Esther M John Adam B Murphy Lisa B Signorello John Carpten M Cristina Leske Suh-Yuh Wu Anslem J M Hennis Christine Neslund-Dudas Ann W Hsing Lisa Chu Phyllis J Goodman Eric A Klein John S Witte Graham Casey Sam Kaggwa Michael B Cook Daniel O Stram William J Blot Rosalind A Eeles Douglas Easton Zsofia Kote-Jarai Ali Amin Al Olama Sara Benlloch Kenneth Muir Graham G Giles Melissa C Southey Liesel M Fitzgerald Henrik Gronberg Fredrik Wiklund Markus Aly Brian E Henderson Johanna Schleutker Tiina Wahlfors Teuvo L J Tammela Børge G Nordestgaard Tim J Key Ruth C Travis David E Neal Jenny L Donovan Freddie C Hamdy Paul Pharoah Nora Pashayan Kay-Tee Khaw Janet L Stanford Stephen N Thibodeau Shannon K McDonnell Daniel J Schaid Christiane Maier Walther Vogel Manuel Luedeke Kathleen Herkommer Adam S Kibel Cezary Cybulski Dominika Wokolorczyk Wojciech Kluzniak Lisa Cannon-Albright Craig Teerlink Hermann Brenner Aida K Dieffenbach Volker Arndt Jong Y Park Thomas A Sellers Hui-Yi Lin Chavdar Slavov Radka Kaneva Vanio Mitev Jyotsna Batra Amanda Spurdle Judith A Clements Manuel R Teixeira Hardev Pandha Agnieszka Michael Paula Paulo Sofia Maia Andrzej Kierzek David V Conti Demetrius Albanes Christine Berg Sonja I Berndt Daniele Campa E David Crawford W Ryan Diver Susan M Gapstur J Michael Gaziano Edward Giovannucci Robert Hoover David J Hunter Mattias Johansson Peter Kraft Loic Le Marchand Sara Lindström Carmen Navarro Kim Overvad Elio Riboli Afshan Siddiq Victoria L Stevens Dimitrios Trichopoulos Paolo Vineis Meredith Yeager Gosia Trynka Soumya Raychaudhuri Frederick R Schumacher Alkes L Price Matthew L Freedman Christopher A Haiman Bogdan Pasaniuc

Nat Commun 2016 Apr 7;7:10979. Epub 2016 Apr 7.

Bioinformatics Interdepartmental Program, University of California Los Angeles, Los Angeles, California 90095, USA.

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http://dx.doi.org/10.1038/ncomms10979DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4829663PMC
April 2016

Integration of multiethnic fine-mapping and genomic annotation to prioritize candidate functional SNPs at prostate cancer susceptibility regions.

Hum Mol Genet 2015 Oct 10;24(19):5603-18. Epub 2015 Jul 10.

Department of Preventive Medicine, Keck School of Medicine, Norris Comprehensive Cancer Center,

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http://dx.doi.org/10.1093/hmg/ddv269DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4572069PMC
October 2015

The HOXB13 G84E Mutation Is Associated with an Increased Risk for Prostate Cancer and Other Malignancies.

Cancer Epidemiol Biomarkers Prev 2015 Sep 24;24(9):1366-72. Epub 2015 Jun 24.

Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota.

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http://dx.doi.org/10.1158/1055-9965.EPI-15-0247DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4560608PMC
September 2015

Genome-wide association scan for variants associated with early-onset prostate cancer.

PLoS One 2014 16;9(4):e93436. Epub 2014 Apr 16.

Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, United States of America; Department of Urology, University of Michigan, Ann Arbor, Michigan, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0093436PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3989171PMC
January 2015

Do environmental factors modify the genetic risk of prostate cancer?

Cancer Epidemiol Biomarkers Prev 2015 Jan 23;24(1):213-20. Epub 2014 Oct 23.

Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland. Brady Urological Institute and Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins Medical Institutions, Baltimore, Maryland.

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http://dx.doi.org/10.1158/1055-9965.EPI-14-0786-TDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4337874PMC
January 2015

Polymorphisms influencing prostate-specific antigen concentration may bias genome-wide association studies on prostate cancer.

Cancer Epidemiol Biomarkers Prev 2015 Jan 28;24(1):88-93. Epub 2014 Oct 28.

Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland. Department of Urology and the James Buchanan Brady Urological Institute, Johns Hopkins School of Medicine, Baltimore, Maryland. Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland.

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http://dx.doi.org/10.1158/1055-9965.EPI-14-0863DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4294961PMC
January 2015

A peripheral circulating TH1 cytokine profile is inversely associated with prostate cancer risk in CLUE II.

Cancer Epidemiol Biomarkers Prev 2014 Nov 22;23(11):2561-7. Epub 2014 Aug 22.

Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland. Department of Urology and James Buchanan Brady Urological Institute, Johns Hopkins School of Medicine, Baltimore, Maryland. Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland.

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http://dx.doi.org/10.1158/1055-9965.EPI-14-0010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4648294PMC
November 2014

A meta-analysis of 87,040 individuals identifies 23 new susceptibility loci for prostate cancer.

Authors:
Ali Amin Al Olama Zsofia Kote-Jarai Sonja I Berndt David V Conti Fredrick Schumacher Ying Han Sara Benlloch Dennis J Hazelett Zhaoming Wang Ed Saunders Daniel Leongamornlert Sara Lindstrom Sara Jugurnauth-Little Tokhir Dadaev Malgorzata Tymrakiewicz Daniel O Stram Kristin Rand Peggy Wan Alex Stram Xin Sheng Loreall C Pooler Karen Park Lucy Xia Jonathan Tyrer Laurence N Kolonel Loic Le Marchand Robert N Hoover Mitchell J Machiela Merideth Yeager Laurie Burdette Charles C Chung Amy Hutchinson Kai Yu Chee Goh Mahbubl Ahmed Koveela Govindasami Michelle Guy Teuvo L J Tammela Anssi Auvinen Tiina Wahlfors Johanna Schleutker Tapio Visakorpi Katri A Leinonen Jianfeng Xu Markus Aly Jenny Donovan Ruth C Travis Tim J Key Afshan Siddiq Federico Canzian Kay-Tee Khaw Atsushi Takahashi Michiaki Kubo Paul Pharoah Nora Pashayan Maren Weischer Borge G Nordestgaard Sune F Nielsen Peter Klarskov Martin Andreas Røder Peter Iversen Stephen N Thibodeau Shannon K McDonnell Daniel J Schaid Janet L Stanford Suzanne Kolb Sarah Holt Beatrice Knudsen Antonio Hurtado Coll Susan M Gapstur W Ryan Diver Victoria L Stevens Christiane Maier Manuel Luedeke Kathleen Herkommer Antje E Rinckleb Sara S Strom Curtis Pettaway Edward D Yeboah Yao Tettey Richard B Biritwum Andrew A Adjei Evelyn Tay Ann Truelove Shelley Niwa Anand P Chokkalingam Lisa Cannon-Albright Cezary Cybulski Dominika Wokołorczyk Wojciech Kluźniak Jong Park Thomas Sellers Hui-Yi Lin William B Isaacs Alan W Partin Hermann Brenner Aida Karina Dieffenbach Christa Stegmaier Constance Chen Edward L Giovannucci Jing Ma Meir Stampfer Kathryn L Penney Lorelei Mucci Esther M John Sue A Ingles Rick A Kittles Adam B Murphy Hardev Pandha Agnieszka Michael Andrzej M Kierzek William Blot Lisa B Signorello Wei Zheng Demetrius Albanes Jarmo Virtamo Stephanie Weinstein Barbara Nemesure John Carpten Cristina Leske Suh-Yuh Wu Anselm Hennis Adam S Kibel Benjamin A Rybicki Christine Neslund-Dudas Ann W Hsing Lisa Chu Phyllis J Goodman Eric A Klein S Lilly Zheng Jyotsna Batra Judith Clements Amanda Spurdle Manuel R Teixeira Paula Paulo Sofia Maia Chavdar Slavov Radka Kaneva Vanio Mitev John S Witte Graham Casey Elizabeth M Gillanders Daniella Seminara Elio Riboli Freddie C Hamdy Gerhard A Coetzee Qiyuan Li Matthew L Freedman David J Hunter Kenneth Muir Henrik Gronberg David E Neal Melissa Southey Graham G Giles Gianluca Severi Michael B Cook Hidewaki Nakagawa Fredrik Wiklund Peter Kraft Stephen J Chanock Brian E Henderson Douglas F Easton Rosalind A Eeles Christopher A Haiman

Nat Genet 2014 Oct 14;46(10):1103-9. Epub 2014 Sep 14.

1] Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, USA. [2] Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California, USA. [3].

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http://dx.doi.org/10.1038/ng.3094DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4383163PMC
October 2014

AR-V7 and resistance to enzalutamide and abiraterone in prostate cancer.

N Engl J Med 2014 Sep 3;371(11):1028-38. Epub 2014 Sep 3.

From the Departments of Oncology (E.S.A., H.W., B.L., J.T.I., R.N., C.J.P., S.R.D., M.A.C., M.A.E.), Pathology (H.L.F., T.L.L., Q.Z., A.M.D.M.), and Urology (C.L., M.N., J.C.R., Yan Chen, W.B.I., J.L.), Johns Hopkins University School of Medicine, Baltimore; and Greehey Children's Cancer Research Institute (T.A.M., Yidong Chen) and the Department of Epidemiology and Biostatistics (Yidong Chen), University of Texas Health Science Center at San Antonio, San Antonio.

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http://dx.doi.org/10.1056/NEJMoa1315815DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4201502PMC
September 2014

Mobile DNA in cancer. Extensive transduction of nonrepetitive DNA mediated by L1 retrotransposition in cancer genomes.

Science 2014 Aug;345(6196):1251343

Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire, UK.

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http://dx.doi.org/10.1126/science.1251343DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4380235PMC
August 2014

Prevalence of the HOXB13 G84E prostate cancer risk allele in men treated with radical prostatectomy.

BJU Int 2014 May 5;113(5):830-5. Epub 2014 Mar 5.

Department of Oncology, Wayne State University, Detroit, MI, USA; Barbara Ann Karmanos Cancer Institute, Population Studies and Disparities Research Program, Detroit, MI, USA.

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http://dx.doi.org/10.1111/bju.12522DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3984347PMC
May 2014

Telomere length as a risk factor for hereditary prostate cancer.

Prostate 2014 Apr 28;74(4):359-64. Epub 2013 Nov 28.

Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland.

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http://dx.doi.org/10.1002/pros.22755DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4479489PMC
April 2014

Rb loss is characteristic of prostatic small cell neuroendocrine carcinoma.

Clin Cancer Res 2014 Feb 9;20(4):890-903. Epub 2013 Dec 9.

Authors' Affiliations: Pathology, Department of Pathology, Henry Ford Health System, Detroit, Michigan; Oncology, and Urology, Johns Hopkins University School of Medicine, Baltimore, Maryland; and Center for Genomics and Personalized Medicine Research, Wake Forest School of Medicine, Winston-Salem, North Carolina.

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http://dx.doi.org/10.1158/1078-0432.CCR-13-1982DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3931005PMC
February 2014

Loss of PTEN is associated with aggressive behavior in ERG-positive prostate cancer.

Cancer Epidemiol Biomarkers Prev 2013 Dec 1;22(12):2333-44. Epub 2013 Oct 1.

Authors' Affiliations: Institute of Biomedical Technology and Institute of Signal Processing, Prostate Cancer Research Center, BioMediTech, Department of Urology, School of Medicine, University of Tampere and Tampere University Hospital, Tampere, Finland; Departments of Pathology and Urology, Jikei University School of Medicine, Minato-ku, Tokyo; Department of Urology, Toho University Sakura Medical Center, Sakura, Chiba, Japan; Departments of Pathology and Urology, Johns Hopkins University, Baltimore, Maryland; and Department of Clinical Chemistry, Helsinki University Central Hospital, Helsinki, Finland.

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http://dx.doi.org/10.1158/1055-9965.EPI-13-0333-TDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4086660PMC
December 2013

Infections and inflammation in prostate cancer.

Am J Clin Exp Urol 2013 Dec;1(1):3-11

Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21287 ; Department of Urology, James Buchanan Brady Urological Institute, Johns Hopkins University School of Medicine, Baltimore, MD.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4219279PMC
December 2013

The role of genetic markers in the management of prostate cancer.

Eur Urol 2012 Oct 5;62(4):577-87. Epub 2012 Jun 5.

Dana-Farber Cancer Institute, Boston, MA 02215, USA.

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http://dx.doi.org/10.1016/j.eururo.2012.05.054DOI Listing
October 2012

Variation in IL10 and other genes involved in the immune response and in oxidation and prostate cancer recurrence.

Cancer Epidemiol Biomarkers Prev 2012 Oct 2;21(10):1774-82. Epub 2012 Aug 2.

Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, 615 N. Wolfe St., Baltimore, MD 21205, USA.

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http://dx.doi.org/10.1158/1055-9965.EPI-12-0458DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3467312PMC
October 2012

Genome-wide two-locus epistasis scans in prostate cancer using two European populations.

Hum Genet 2012 Jul 26;131(7):1225-34. Epub 2012 Feb 26.

Center for Genetic Epidemiology and Prevention, Van Andel Research Institute, Grand Rapids, MI, USA.

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http://dx.doi.org/10.1007/s00439-012-1148-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3634576PMC
July 2012

Inherited susceptibility for aggressive prostate cancer.

Authors:
William B Isaacs

Asian J Androl 2012 May 30;14(3):415-8. Epub 2012 Apr 30.

Brady Urological Institute, Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA.

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http://dx.doi.org/10.1038/aja.2011.146DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3568760PMC
May 2012

A genome-wide search for loci interacting with known prostate cancer risk-associated genetic variants.

Carcinogenesis 2012 Mar 4;33(3):598-603. Epub 2012 Jan 4.

Center for Genetic Epidemiology and Prevention, Van Andel Research Institute, Grand Rapids, MI, USA.

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http://dx.doi.org/10.1093/carcin/bgr316DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3291863PMC
March 2012

Human polymorphisms at long non-coding RNAs (lncRNAs) and association with prostate cancer risk.

Carcinogenesis 2011 Nov 19;32(11):1655-9. Epub 2011 Aug 19.

Center for Cancer Genomics, Wake Forest University School of Medicine, Medical Center Boulevard, Winston-Salem, NC 27157, USA.

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http://dx.doi.org/10.1093/carcin/bgr187DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3204347PMC
November 2011