Publications by authors named "William Astle"

47Publications

The Polygenic and Monogenic Basis of Blood Traits and Diseases.

Authors:
Dragana Vuckovic Erik L Bao Parsa Akbari Caleb A Lareau Abdou Mousas Tao Jiang Ming-Huei Chen Laura M Raffield Manuel Tardaguila Jennifer E Huffman Scott C Ritchie Karyn Megy Hannes Ponstingl Christopher J Penkett Patrick K Albers Emilie M Wigdor Saori Sakaue Arden Moscati Regina Manansala Ken Sin Lo Huijun Qian Masato Akiyama Traci M Bartz Yoav Ben-Shlomo Andrew Beswick Jette Bork-Jensen Erwin P Bottinger Jennifer A Brody Frank J A van Rooij Kumaraswamy N Chitrala Peter W F Wilson Hélène Choquet John Danesh Emanuele Di Angelantonio Niki Dimou Jingzhong Ding Paul Elliott Tõnu Esko Michele K Evans Stephan B Felix James S Floyd Linda Broer Niels Grarup Michael H Guo Qi Guo Andreas Greinacher Jeff Haessler Torben Hansen Joanna M M Howson Wei Huang Eric Jorgenson Tim Kacprowski Mika Kähönen Yoichiro Kamatani Masahiro Kanai Savita Karthikeyan Fotios Koskeridis Leslie A Lange Terho Lehtimäki Allan Linneberg Yongmei Liu Leo-Pekka Lyytikäinen Ani Manichaikul Koichi Matsuda Karen L Mohlke Nina Mononen Yoshinori Murakami Girish N Nadkarni Kjell Nikus Nathan Pankratz Oluf Pedersen Michael Preuss Bruce M Psaty Olli T Raitakari Stephen S Rich Benjamin A T Rodriguez Jonathan D Rosen Jerome I Rotter Petra Schubert Cassandra N Spracklen Praveen Surendran Hua Tang Jean-Claude Tardif Mohsen Ghanbari Uwe Völker Henry Völzke Nicholas A Watkins Stefan Weiss Na Cai Kousik Kundu Stephen B Watt Klaudia Walter Alan B Zonderman Kelly Cho Yun Li Ruth J F Loos Julian C Knight Michel Georges Oliver Stegle Evangelos Evangelou Yukinori Okada David J Roberts Michael Inouye Andrew D Johnson Paul L Auer William J Astle Alexander P Reiner Adam S Butterworth Willem H Ouwehand Guillaume Lettre Vijay G Sankaran Nicole Soranzo

Cell 2020 Sep;182(5):1214-1231.e11

Human Genetics, Wellcome Sanger Institute, Hinxton, CB10 1SA, UK; National Institute for Health Research Blood and Transplant Research Unit (NIHR BTRU) in Donor Health and Genomics, University of Cambridge, Cambridge, CB1 8RN, UK; British Heart Foundation Centre of Excellence, Division of Cardiovascular Medicine, Addenbrooke's Hospital, Cambridge, CB2 0QQ, UK; Department of Haematology, University of Cambridge, Cambridge, CB2 0PT, UK. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2020.08.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7482360PMC
September 2020

Trans-ethnic and Ancestry-Specific Blood-Cell Genetics in 746,667 Individuals from 5 Global Populations.

Authors:
Ming-Huei Chen Laura M Raffield Abdou Mousas Saori Sakaue Jennifer E Huffman Arden Moscati Bhavi Trivedi Tao Jiang Parsa Akbari Dragana Vuckovic Erik L Bao Xue Zhong Regina Manansala Véronique Laplante Minhui Chen Ken Sin Lo Huijun Qian Caleb A Lareau Mélissa Beaudoin Karen A Hunt Masato Akiyama Traci M Bartz Yoav Ben-Shlomo Andrew Beswick Jette Bork-Jensen Erwin P Bottinger Jennifer A Brody Frank J A van Rooij Kumaraswamynaidu Chitrala Kelly Cho Hélène Choquet Adolfo Correa John Danesh Emanuele Di Angelantonio Niki Dimou Jingzhong Ding Paul Elliott Tõnu Esko Michele K Evans James S Floyd Linda Broer Niels Grarup Michael H Guo Andreas Greinacher Jeff Haessler Torben Hansen Joanna M M Howson Qin Qin Huang Wei Huang Eric Jorgenson Tim Kacprowski Mika Kähönen Yoichiro Kamatani Masahiro Kanai Savita Karthikeyan Fotis Koskeridis Leslie A Lange Terho Lehtimäki Markus M Lerch Allan Linneberg Yongmei Liu Leo-Pekka Lyytikäinen Ani Manichaikul Hilary C Martin Koichi Matsuda Karen L Mohlke Nina Mononen Yoshinori Murakami Girish N Nadkarni Matthias Nauck Kjell Nikus Willem H Ouwehand Nathan Pankratz Oluf Pedersen Michael Preuss Bruce M Psaty Olli T Raitakari David J Roberts Stephen S Rich Benjamin A T Rodriguez Jonathan D Rosen Jerome I Rotter Petra Schubert Cassandra N Spracklen Praveen Surendran Hua Tang Jean-Claude Tardif Richard C Trembath Mohsen Ghanbari Uwe Völker Henry Völzke Nicholas A Watkins Alan B Zonderman Peter W F Wilson Yun Li Adam S Butterworth Jean-François Gauchat Charleston W K Chiang Bingshan Li Ruth J F Loos William J Astle Evangelos Evangelou David A van Heel Vijay G Sankaran Yukinori Okada Nicole Soranzo Andrew D Johnson Alexander P Reiner Paul L Auer Guillaume Lettre

Cell 2020 Sep;182(5):1198-1213.e14

Montreal Heart Institute, Montreal, QC H1T 1C8, Canada; Department of Medicine, Faculty of Medicine, Université de Montréal, Montreal, QC H3T 1J4, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2020.06.045DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7480402PMC
September 2020

Risk thresholds for alcohol consumption: combined analysis of individual-participant data for 599 912 current drinkers in 83 prospective studies.

Authors:
Angela M Wood Stephen Kaptoge Adam S Butterworth Peter Willeit Samantha Warnakula Thomas Bolton Ellie Paige Dirk S Paul Michael Sweeting Stephen Burgess Steven Bell William Astle David Stevens Albert Koulman Randi M Selmer W M Monique Verschuren Shinichi Sato Inger Njølstad Mark Woodward Veikko Salomaa Børge G Nordestgaard Bu B Yeap Astrid Fletcher Olle Melander Lewis H Kuller Beverley Balkau Michael Marmot Wolfgang Koenig Edoardo Casiglia Cyrus Cooper Volker Arndt Oscar H Franco Patrik Wennberg John Gallacher Agustín Gómez de la Cámara Henry Völzke Christina C Dahm Caroline E Dale Manuela M Bergmann Carlos J Crespo Yvonne T van der Schouw Rudolf Kaaks Leon A Simons Pagona Lagiou Josje D Schoufour Jolanda M A Boer Timothy J Key Beatriz Rodriguez Conchi Moreno-Iribas Karina W Davidson James O Taylor Carlotta Sacerdote Robert B Wallace J Ramon Quiros Rosario Tumino Dan G Blazer Allan Linneberg Makoto Daimon Salvatore Panico Barbara Howard Guri Skeie Timo Strandberg Elisabete Weiderpass Paul J Nietert Bruce M Psaty Daan Kromhout Elena Salamanca-Fernandez Stefan Kiechl Harlan M Krumholz Sara Grioni Domenico Palli José M Huerta Jackie Price Johan Sundström Larraitz Arriola Hisatomi Arima Ruth C Travis Demosthenes B Panagiotakos Anna Karakatsani Antonia Trichopoulou Tilman Kühn Diederick E Grobbee Elizabeth Barrett-Connor Natasja van Schoor Heiner Boeing Kim Overvad Jussi Kauhanen Nick Wareham Claudia Langenberg Nita Forouhi Maria Wennberg Jean-Pierre Després Mary Cushman Jackie A Cooper Carlos J Rodriguez Masaru Sakurai Jonathan E Shaw Matthew Knuiman Trudy Voortman Christa Meisinger Anne Tjønneland Hermann Brenner Luigi Palmieri Jean Dallongeville Eric J Brunner Gerd Assmann Maurizio Trevisan Richard F Gillum Ian Ford Naveed Sattar Mariana Lazo Simon G Thompson Pietro Ferrari David A Leon George Davey Smith Richard Peto Rod Jackson Emily Banks Emanuele Di Angelantonio John Danesh

Lancet 2018 04;391(10129):1513-1523

Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK. Electronic address:

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http://dx.doi.org/10.1016/S0140-6736(18)30134-XDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5899998PMC
April 2018

Incidental neuroblastoma with bilateral retinoblastoma: what are the chances?

Ophthalmic Genet 2018 06 16;39(3):410-413. Epub 2018 Jan 16.

d Department of Ophthalmology and Visual Sciences , University of Toronto , Toronto, ON , Canada.

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http://dx.doi.org/10.1080/13816810.2018.1424208DOI Listing
June 2018

The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease.

Cell 2016 11;167(5):1415-1429.e19

Department of Haematology, University of Cambridge, Cambridge Biomedical Campus, Long Road, Cambridge CB2 0PT, UK; Department of Human Genetics, The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1HH, UK; The National Institute for Health Research Blood and Transplant Unit (NIHR BTRU) in Donor Health and Genomics at the University of Cambridge, University of Cambridge, Strangeways Research Laboratory, Wort's Causeway, Cambridge CB1 8RN, UK; British Heart Foundation Centre of Excellence, Division of Cardiovascular Medicine, Addenbrooke's Hospital, Hills Road, Cambridge CB2 0QQ, UK. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2016.10.042DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5300907PMC
November 2016

A workforce in crisis: a case study to expand allied ophthalmic personnel.

Can J Ophthalmol 2016 Aug 30;51(4):288-293. Epub 2016 Jun 30.

Joint Commission on Allied Health Personnel in Ophthalmology, St. Paul, Minn.. Electronic address:

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http://dx.doi.org/10.1016/j.jcjo.2016.04.008DOI Listing
August 2016

Postoperative glaucoma following infantile cataract surgery: an individual patient data meta-analysis.

JAMA Ophthalmol 2014 Sep;132(9):1059-67

Clinical and Academic Department of Ophthalmology, Great Ormond Street Hospital, London, England14UPMC Eye Center, Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania.

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http://dx.doi.org/10.1001/jamaophthalmol.2014.1042DOI Listing
September 2014

Bayesian deconvolution and quantification of metabolites in complex 1D NMR spectra using BATMAN.

Nat Protoc 2014 22;9(6):1416-27. Epub 2014 May 22.

Computational and Systems Medicine, Department of Surgery and Cancer, Imperial College London, London, UK.

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http://dx.doi.org/10.1038/nprot.2014.090DOI Listing
December 2014

Flexible analysis of RNA-seq data using mixed effects models.

Bioinformatics 2014 Jan 26;30(2):180-8. Epub 2013 Nov 26.

Cancer Research UK Cambridge Institute, University of Cambridge, Robinson Way, Cambridge CB2 0RE, UK, Department of Haematology, University of Cambridge, NHS Blood and Transplant, Long Road, Cambridge CB2 0PT, UK and Department of Epidemiology, Biostatistics and Occupational Health, McGill University, 1020 Pine Avenue West, Montreal QC H3A 1A2, Canada.

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http://dx.doi.org/10.1093/bioinformatics/btt624DOI Listing
January 2014

BATMAN--an R package for the automated quantification of metabolites from nuclear magnetic resonance spectra using a Bayesian model.

Bioinformatics 2012 Aug 26;28(15):2088-90. Epub 2012 May 26.

Section of Biomolecular Medicine, Department of Surgery and Cancer, Sir Alexander Fleming Building, Imperial College London, London SW7 2AZ, UK.

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https://academic.oup.com/bioinformatics/article-lookup/doi/1
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http://dx.doi.org/10.1093/bioinformatics/bts308DOI Listing
August 2012

Laser-assisted subepithelial keratectomy for bilateral hyperopia and hyperopic anisometropic amblyopia in children: one-year outcomes.

J Cataract Refract Surg 2010 Feb;36(2):260-7

Alberta Children's Hospital, University of Calgary, 2888 Shaganappi Trail Northwest, Calgary, Alberta T3B 6A8, Canada.

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http://dx.doi.org/10.1016/j.jcrs.2009.08.022DOI Listing
February 2010

Surgical outcomes of primary foldable intraocular lens implantation in children: understanding posterior opacification and the absence of glaucoma.

J Cataract Refract Surg 2009 Jul;35(7):1216-22

Alberta Children's Hospital, University of Calgary, Division of Ophthalmology, Calgary, Alberta, Canada.

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http://dx.doi.org/10.1016/j.jcrs.2009.02.028DOI Listing
July 2009

Monocular oral reading performance after amblyopia treatment in children.

Am J Ophthalmol 2008 Dec 16;146(6):942-7. Epub 2008 Aug 16.

Wilmer Ophthalmological Institute, Johns Hopkins University, Baltimore, Maryland, USA.

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http://dx.doi.org/10.1016/j.ajo.2008.06.022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2713113PMC
December 2008

Long-term outcomes of photorefractive keratectomy and laser-assisted subepithelial keratectomy in children.

J Cataract Refract Surg 2008 Mar;34(3):411-6

Alberta Children's Hospital, University of Calgary, Calgary, Alberta, Canada.

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http://dx.doi.org/10.1016/j.jcrs.2007.10.027DOI Listing
March 2008

Laser-assisted subepithelial keratectomy for anisometropic amblyopia in children: outcomes at 1 year.

J Cataract Refract Surg 2007 Dec;33(12):2028-34

Vision Clinic, Alberta Children's Hospital, University of Calgary, Calgary, Alberta, Canada.

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http://dx.doi.org/10.1016/j.jcrs.2007.07.024DOI Listing
December 2007

Enhancing the SAFE strategy through collaboration, participation, accountability and sustainability.

Community Eye Health 2005 Mar;18(53):80

Alberta Children's Hospital, Canada in collaboration with Lusaka Eye Hospital, Zambia.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1705664PMC
March 2005

Paediatric pseudophakia: analysis of intraocular lens power and myopic shift.

Clin Exp Ophthalmol 2007 Apr;35(3):244-51

The Alberta Children's Hospital, University of Calgary, Division of Ophthalmology, Calgary, Alberta, Canada.

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http://dx.doi.org/10.1111/j.1442-9071.2006.01446.xDOI Listing
April 2007

Trachoma control in Southern Zambia--an international team project employing the SAFE strategy.

Ophthalmic Epidemiol 2006 Aug;13(4):227-36

Division of Pediatric Ophthalmology, Alberta Children's Hospital and University of Calgary, Faculty of Medicine, Calgary, Alberta, Canada.

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http://dx.doi.org/10.1080/09286580600718974DOI Listing
August 2006

Refractive laser surgery in children with coexisting medical and ocular pathology.

J Cataract Refract Surg 2006 Jan;32(1):103-8

Alberta Children's Hospital, University of Calgary, Division of Ophthalmology, Canada.

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http://dx.doi.org/10.1016/j.jcrs.2005.11.028DOI Listing
January 2006

Laser-assisted subepithelial keratectomy in children.

J Cataract Refract Surg 2004 Dec;30(12):2529-35

Alberta Children's Hospital, University of Calgary Division of Ophthalmology, Calgary, Alberta, Canada.

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http://dx.doi.org/10.1016/j.jcrs.2004.06.025DOI Listing
December 2004

Telemedicine approach to screening for severe retinopathy of prematurity: a pilot study.

Ophthalmology 2003 Nov;110(11):2113-7

Department of Ophthalmology, Alberta Children's Hospital, Calgary, Canada.

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http://dx.doi.org/10.1016/S0161-6420(03)00831-5DOI Listing
November 2003

Congenital absence of the inferior rectus muscle--diagnosis and management.

J AAPOS 2003 Oct;7(5):339-44

Division of Pediatric Ophthalmology and Strabismus, Alberta Children's Hospital, University of Calgary, 1820 Richmond Road SW, Calgary, Alberta, Canada T2T 5C7.

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http://dx.doi.org/10.1016/s1091-8531(03)00214-3DOI Listing
October 2003

Photorefractive keratectomy in children.

J Cataract Refract Surg 2002 Jun;28(6):932-41

Alberta Children's Hospital, University of Calgary, Division of Ophthalmology, Calgary, Alberta, Canada.

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http://dx.doi.org/10.1016/s0886-3350(02)01304-4DOI Listing
June 2002