Publications by authors named "Willi Sauerbrei"

67Publications

Development of the Instrument to assess the Credibility of Effect Modification Analyses (ICEMAN) in randomized controlled trials and meta-analyses.

CMAJ 2020 Aug;192(32):E901-E906

Departments of Health Research Methods, Evidence, and Impact (Schandelmaier, Briel, Walsh, Thabane, Guyatt), Medicine (Walsh, Guyatt), Pediatrics (Thabane) and Anesthesia (Thabane), McMaster University, Hamilton, Ont.; Institute for Clinical Epidemiology and Biostatistics (Schandelmaier, Briel), Department of Clinical Research, Basel University, Basel, Switzerland; Division of Biostatistics and Bioinformatics (Varadhan), Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, Md.; Department of Biostatistics (Schmid), Brown University School of Public Health, Brown University, Providence, RI; Indian institute of Public Health-Delhi (Devasenapathy), Public Health Foundation of India, New Delhi, India; VA Center for Clinical Management and Research (Hayward); Department of Internal Medicine (Hayward), University of Michigan School of Medicine; Department of Orthopaedic Surgery (Gagnier), University of Michigan; Department of Epidemiology (Gagnier), School of Public Health, University of Michigan, Ann Arbor, Mich.; Biostat (Borenstein), Englewood, NJ; Department of Social Dentistry (van der Heijden), Academic Center for Dentistry Amsterdam, University of Amsterdam and VU University Amsterdam, Amsterdam, Netherlands; Center for Evidence Synthesis in Health (Dahabreh) and Departments of Health Services, Policy, and Practice (Dahabreh) and Epidemiology (Dahabreh), School of Public Health, Brown University, Providence, RI; Chinese Evidence-Based Medicine Center (Sun), West China Hospital, Sichuan University, Chengdu, China; Institute of Medical Biometry and Statistics (Sauerbrei), Faculty of Medicine and Medical Center, University of Freiburg, Freiburg, Germany; Population Health Research Institute (Walsh), Hamilton Health Sciences/McMaster University, Hamilton, Ont.; Departments of Medicine (Ioannidis), Health Research and Policy (Ioannidis) and Biomedical Data Science (Ioannidis), and Statistics and Meta-Research Innovation Center at Stanford (METRICS) (Ioannidis), Stanford University, Stanford, Calif.; Biostatistics Unit (Thabane), St. Joseph's Healthcare, Hamilton, Ont.

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http://dx.doi.org/10.1503/cmaj.200077DOI Listing
August 2020

Doug Altman: Driving critical appraisal and improvements in the quality of methodological and medical research.

Biom J 2020 Jul 8. Epub 2020 Jul 8.

Centre for Statistics in Medicine, Nuffield Department of Orthopaedics, Rheumatology & Musculoskeletal Sciences, University of Oxford, Oxford, UK.

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http://dx.doi.org/10.1002/bimj.202000053DOI Listing
July 2020

Statistical models for complex data in clinical and epidemiological research.

Biom J 2020 05;62(3):528-531

Clinical Trials Unit, Faculty of Medicine and Medical Center, University of Freiburg, Germany.

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http://dx.doi.org/10.1002/bimj.202000079DOI Listing
May 2020

State of the art in selection of variables and functional forms in multivariable analysis-outstanding issues.

Diagn Progn Res 2020 2;4. Epub 2020 Apr 2.

6Section for Clinical Biometrics, Center for Medical Statistics, Informatics and Intelligent Systems, Medical University of Vienna, Vienna, Austria.

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http://dx.doi.org/10.1186/s41512-020-00074-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7114804PMC
April 2020

Combining clinical and molecular data in regression prediction models: insights from a simulation study.

Brief Bioinform 2019 Nov 21. Epub 2019 Nov 21.

Institute of Medical Biometry and Statistics, University of Freiburg, Germany.

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http://dx.doi.org/10.1093/bib/bbz136DOI Listing
November 2019

A plea for taking all available clinical information into account when assessing the predictive value of omics data.

BMC Med Res Methodol 2019 07 24;19(1):162. Epub 2019 Jul 24.

Institute for Medical Information Processing, Biometry and Epidemiology, University of Munich, Marchioninistr. 15, Munich, 81377, Germany.

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http://dx.doi.org/10.1186/s12874-019-0802-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6657034PMC
July 2019

A review of spline function procedures in R.

BMC Med Res Methodol 2019 03 6;19(1):46. Epub 2019 Mar 6.

Medical Biometry, Informatics and Epidemiology, Faculty of Medicine, University of Bonn, Bonn, Germany.

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https://bmcmedresmethodol.biomedcentral.com/articles/10.1186
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http://dx.doi.org/10.1186/s12874-019-0666-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6402144PMC
March 2019

Overinterpretation and misreporting of prognostic factor studies in oncology: a systematic review.

Br J Cancer 2018 11 24;119(10):1288-1296. Epub 2018 Oct 24.

Centre for Statistics in Medicine, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, Botnar Research Centre, University of Oxford, Oxford, UK.

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http://www.nature.com/articles/s41416-018-0305-5
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http://dx.doi.org/10.1038/s41416-018-0305-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6251031PMC
November 2018

Meta-analysis of non-linear exposure-outcome relationships using individual participant data: A comparison of two methods.

Stat Med 2019 02 3;38(3):326-338. Epub 2018 Oct 3.

ERFC Investigators/Collaborators are listed in the Appendix (Supplementary Materials).

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http://doi.wiley.com/10.1002/sim.7974
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http://dx.doi.org/10.1002/sim.7974DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6492097PMC
February 2019

Education for biometry in practice.

Biom J 2018 09 12;60(5):1021. Epub 2018 Aug 12.

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http://dx.doi.org/10.1002/bimj.201800209DOI Listing
September 2018

Reporting Recommendations for Tumor Marker Prognostic Studies (REMARK): An Abridged Explanation and Elaboration.

J Natl Cancer Inst 2018 08;110(8):803-811

Centre for Statistics in Medicine, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK.

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http://dx.doi.org/10.1093/jnci/djy088DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6093349PMC
August 2018

Comment on 'BAG-1 as a biomarker in early breast cancer prognosis: a systematic review with meta-analyses'.

Br J Cancer 2018 04 15;118(8):1152-1153. Epub 2018 Mar 15.

Institute for Medical Biometry and Statistics, Faculty of Medicine and Medical Center, University of Freiburg, Freiburg, Germany.

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http://dx.doi.org/10.1038/s41416-018-0023-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5931108PMC
April 2018

On the necessity and design of studies comparing statistical methods.

Biom J 2018 01 29;60(1):216-218. Epub 2017 Nov 29.

Institute for Medical Biometry and Statistics, Faculty of Medicine and Medical Center, University of Freiburg, Stefan-Meier-Str. 26, 79104, Freiburg, Germany.

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http://dx.doi.org/10.1002/bimj.201700129DOI Listing
January 2018

Did the reporting of prognostic studies of tumour markers improve since the introduction of REMARK guideline? A comparison of reporting in published articles.

PLoS One 2017 14;12(6):e0178531. Epub 2017 Jun 14.

Institute for Medical Biometry and Statistics, Faculty of Medicine and Medical Center-University of Freiburg, Freiburg, Germany.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0178531PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5470677PMC
September 2017

Importance of the distinction between quality of methodology and quality of reporting.

HPB (Oxford) 2017 07 21;19(7):649-650. Epub 2017 Apr 21.

National Institutes of Health, National Cancer Institute, 9609 Medical Center Drive, MSC 9735, Bethesda, MD 20892-97, USA.

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http://dx.doi.org/10.1016/j.hpb.2017.02.444DOI Listing
July 2017

Modeling Variables With a Spike at Zero: Examples and Practical Recommendations.

Am J Epidemiol 2017 04;185(8):650-660

Institute of Public Health, University of Heidelberg, Heidelberg, Germany.

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http://dx.doi.org/10.1093/aje/kww122DOI Listing
April 2017

Erratum to: Methods for evaluating medical tests and biomarkers.

Authors:
Gowri Gopalakrishna Miranda Langendam Rob Scholten Patrick Bossuyt Mariska Leeflang Anna Noel-Storr James Thomas Iain Marshall Byron Wallace Penny Whiting Clare Davenport Mariska Leeflang Gowri GopalaKrishna Isabel de Salis Sue Mallett Robert Wolff Penny Whiting Richard Riley Marie Westwood Jos Kleinen Gary Collins Hans Reitsma Karel Moons Antonia Zapf Annika Hoyer Katharina Kramer Oliver Kuss J Ensor J J Deeks E C Martin R D Riley Gerta Rücker Susanne Steinhauser Martin Schumacher Richard Riley Joie Ensor Kym Snell Brian Willis Thomas Debray Karel Moons Jon Deeks Gary Collins Lavinia Ferrante di Ruffano Brian Willis Clare Davenport Sue Mallett Sian Taylor-Phillips Chris Hyde Jon Deeks Sue Mallett Stuart A Taylor Gauraang Batnagar Sian Taylor-Phillips Lavinia Ferrante Di Ruffano Farah Seedat Aileen Clarke Jon Deeks Sarah Byron Frances Nixon Rebecca Albrow Thomas Walker Carla Deakin Chris Hyde Zhivko Zhelev Harriet Hunt Lavinia Ferrante di Ruffano Yaling Yang Lucy Abel James Buchanan Thomas Fanshawe Bethany Shinkins Laure Wynants Jan Verbakel Sabine Van Huffel Dirk Timmerman Ben Van Calster Mariska Leeflang Aeliko Zwinderman Patrick Bossuyt Jason Oke Jack O'Sullivan Rafael Perera Brian Nicholson Hannah L Bromley Tracy E Roberts Adele Francis Denniis Petrie G Bruce Mann Kinga Malottki Holly Smith Jon Deeks Lucinda Billingham Alice Sitch Sue Mallett Jon Deeks Oke Gerke Mie Holm-Vilstrup Eivind Antonsen Segtnan Ulrich Halekoh Poul Flemming Høilund-Carlsen Bernard G Francq Jon Deeks Alice Sitch Jac Dinnes Julie Parkes Walter Gregory Jenny Hewison Doug Altman William Rosenberg Peter Selby Julien Asselineau Paul Perez Aïssatou Paye Emilie Bessede Cécile Proust-Lima Christiana Naaktgeboren Joris de Groot Anne Rutjes Patrick Bossuyt Johannes Reitsma Karel Moons Gary Collins Emmanuel Ogundimu Jonathan Cook Yannick Le Manach Doug Altman Laure Wynants Yvonne Vergouwe Sabine Van Huffel Dirk Timmerman Ben Van Calster Romin Pajouheshnia Rolf Groenwold Karen Moons Johannes Reitsma Linda Peelen Ben Van Calster Daan Nieboer Yvonne Vergouwe Bavo De Cock Micael J Pencina Ewout W Steyerberg Jennifer Cooper Sian Taylor-Phillips Nick Parsons Chris Stinton Steve Smith Andy Dickens Rachel Jordan Alexandra Enocson David Fitzmaurice Alice Sitch Peymane Adab Bernard G Francq Charles Boachie Gaj Vidmar Karoline Freeman Martin Connock Sian Taylor-Phillips Rachel Court Aileen Clarke Joris de Groot Christiana Naaktgeboren Hans Reitsma Carl Moons Jessica Harris Andrew Mumford Zoe Plummer Kurtis Lee Barnaby Reeves Chris Rogers Veerle Verheyden Gianni D Angelini Gavin J Murphy Jeremy Huddy Melody Ni Katherine Good Graham Cooke Patrick Bossuyt George Hanna Jie Ma Doug Altman Gary Collins K G M Carl Moons Joris A H de Groot Sue Mallett Doug G Altman Johannes B Reitsma Gary S Collins Karel G M Moons Douglas G Altman Johannes B Reitsma Gary S Collins Adina Najwa Kamarudin Ruwanthi Kolamunnage-Dona Trevor Cox Melody Ni Jeremy Huddy Simone Borsci George Hanna Teresa Pérez M Carmen Pardo Angel Candela-Toha Alfonso Muriel Javier Zamora Sabina Sanghera Syed Mohiuddin Richard Martin Jenny Donovan Joanna Coast Mikyung Kelly Seo John Cairns Elizabeth Mitchell Alison Smith Judy Wright Peter Hall Michael Messenger Nicola Calder Nyantara Wickramasekera Karen Vinall-Collier Andrew Lewington Romin Pajouheshnia Johanna Damen Rolf Groenwold Karel Moons Linda Peelen Michael Messenger David Cairns Alison Smith Michelle Hutchinson Judy Wright Peter Hall Nicola Calder Cathie Sturgeon Liz Mitchel Rebecca Kift Sofia Christakoudi Manohursingh Rungall Paula Mobillo Rosa Montero Tjir-Li Tsui Sui Phin Kon Beatriz Tucker Steven Sacks Chris Farmer Terry Strom Paramit Chowdhury Irene Rebollo-Mesa Maria Hernandez-Fuentes Johanna A A G Damen Thomas P A Debray Pauline Heus Lotty Hooft Karel G M Moons Romin Pajouheshnia Johannes B Reitsma Rob J P M Scholten Johanna A A G Damen Lotty Hooft Ewoud Schuit Thomas P A Debray Gary S Collins Ioanna Tzoulaki Camille M Lassale George C M Siontis Virginia Chiocchia Corran Roberts Michael Maia Schlüssel Stephen Gerry James A Black Pauline Heus Yvonne T van der Schouw Linda M Peelen Karel G M Moons Johanna A A G Damen Thomas P A Debray Pauline Heus Lotty Hooft Karel G M Moons Romin Pajouheshnia Johannes B Reitsma Rob J P M Scholten Jie Ma Doug Altman Gary Collins Graeme Spence David McCartney Ann van den Bruel Daniel Lasserson Gail Hayward Werner Vach Antoinette de Jong Coreline Burggraaff Otto Hoekstra Josée Zijlstra Henrica de Vet Harriet Hunt Chris Hyde Sara Graziadio Joy Allen Louise Johnston Rachel O'Leary Michael Power Joy Allen Sara Graziadio Louise Johnson Rachel O'Leary Michael Power Ray Waters John Simpson Louise Johnston Joy Allen Sara Graziadio Rachel O'Leary Ray Waters Michael Power Sue Mallett Thomas R Fanshawe Peter Phillips Andrew Plumb Emma Helbren Steve Halligan Stuart A Taylor Alastair Gale Sue Mallett Peggy Sekula Douglas G Altman Willi Sauerbrei Sue Mallett Thomas R Fanshawe Julia R Forman Susan J Dutton Yemisi Takwoingi Elizabeth M Hensor Thomas E Nichols Bethany Shinkins Yaling Yang Lucy Abel Lavinia Ferrante Di Ruffano Thomas Fanshawe Emmanuelle Kempf Raphael Porcher Jennifer de Beyer Karel Moons Douglas Altman Hans Reitsma Sally Hopewell Willi Sauerbrei Gary Collins John Dennis Beverley Shields Angus Jones William Henley Ewan Pearson Andrew Hattersley Pauline Heus Johanna A A G Damen Romin Pajouheshnia Rob J P M Scholten Johannes B Reitsma Gary S Collins Douglas G Altman Karel G M Moons Lotty Hooft Beverley Shields John Dennis Angus Jones William Henley Ewan Pearson Andrew Hattersley Fueloep Scheibler Anne Rummer Sibylle Sturtz Robert Großelfinger Katie Banister Craig Ramsay Augusto Azuara-Blanco Jonathan Cook Charles Boachie Jennifer Burr Manjula Kumarasamy Rupert Bourne Ijeoma Uchegbu Simone Borsci Jennifer Murphy George Hanna Ijeoma Uchegbu Alex Carter Jen Murphy Melody Ni Joachim Marti Julie Eatock Ijeoma Uchegbu Julie Robotham Maria Dudareva Mark Gilchrist Alison Holmes Ijeoma Uchegbu Simone Borsci Phillip Monaghan Sarah Lord Andrew StJohn Sverre Sandberg Christa Cobbaert Lieselotte Lennartz Wilma Verhagen-Kamerbeek Christoph Ebert Patrick Bossuyt Andrea Horvath Kevin Jenniskens Christiana Naaktgeboren Johannes Reitsma Karel Moons Joris de Groot Chris Hyde Jaime Peters Bogdan Grigore Jaime Peters Chris Hyde Chris Hyde Obi Ukoumunne Jaime Peters Zhivko Zhelev Brooke Levis Andrea Benedetti Alexander W Levis John P A Ioannidis Ian Shrier Pim Cuijpers Simon Gilbody Lorie A Kloda Dean McMillan Scott B Patten Russell J Steele Roy C Ziegelstein Charles H Bombardier Flavia de Lima Osório Jesse R Fann Dwenda Gjerdingen Femke Lamers Manote Lotrakul Sonia R Loureiro Bernd Löwe Juwita Shaaban Lesley Stafford Henk C P M van Weert Mary A Whooley Linda S Williams Karin A Wittkampf Albert S Yeung Brett D Thombs Jaime Peters Chris Cooper James Buchanan Tom Nieto Claire Smith Olga Tucker Janine Dretzke Andrew Beggs Nirmala Rai Clare Davenport Sue Bayliss Simon Stevens Kym Snell Sue Mallet Jon Deeks Sudha Sundar Emma Hall Nuria Porta David Lorente Estelles Johann de Bono

Diagn Progn Res 2017 30;1:11. Epub 2017 Mar 30.

278The Institute of Cancer Research, London, UK.

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http://dx.doi.org/10.1186/s41512-017-0011-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6460744PMC
March 2017

Multivariable fractional polynomial interaction to investigate continuous effect modifiers in a meta-analysis on higher versus lower PEEP for patients with ARDS.

BMJ Open 2016 09 8;6(9):e011148. Epub 2016 Sep 8.

Institute for Clinical Epidemiology and Biostatistics, University Hospital Basel, Basel, Switzerland Institute for Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada.

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http://dx.doi.org/10.1136/bmjopen-2016-011148DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5020750PMC
September 2016

Assessment of the extent of unpublished studies in prognostic factor research: a systematic review of p53 immunohistochemistry in bladder cancer as an example.

BMJ Open 2016 08 16;6(8):e009972. Epub 2016 Aug 16.

Department of Urology, Schön-Klinik Nürnberg Fürth, Fürth, Germany Department of Urology, University Clinic of Erlangen, Waldkrankenhaus St. Marien, Erlangen, Germany.

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http://dx.doi.org/10.1136/bmjopen-2015-009972DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5013379PMC
August 2016

Modeling continuous covariates with a "spike" at zero: Bivariate approaches.

Biom J 2016 Jul 13;58(4):783-96. Epub 2016 Apr 13.

Institute of Medical Biometry and Statistics, Freiburg University Medical Centre, Stefan-Meier-Str. 26, 79104 Freiburg, Germany.

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http://dx.doi.org/10.1002/bimj.201400112DOI Listing
July 2016

Improving the Prognostic Ability through Better Use of Standard Clinical Data - The Nottingham Prognostic Index as an Example.

PLoS One 2016 3;11(3):e0149977. Epub 2016 Mar 3.

Universitätsklinikum Freiburg, Institut für Medizinische Biometrie und Statistik, Department für Medizinische Biometrie und Medizinische Informatik, Freiburg, Germany.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0149977PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4777365PMC
July 2016

mfpa: Extension of mfp using the ACD covariate transformation for enhanced parametric multivariable modeling.

Stata J 2016 Jan;16(1):72-87

Center for Medical Biometry and Medical Informatics Medical Center-University of Freiburg, Freiburg, Germany.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5796636PMC
January 2016

Subsampling versus bootstrapping in resampling-based model selection for multivariable regression.

Biometrics 2016 Mar 19;72(1):272-80. Epub 2015 Aug 19.

Department of Medical Informatics, Biometry and Epidemiology, University of Munich, Marchioninistr. 15, 81377 Munich, Germany.

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http://dx.doi.org/10.1111/biom.12381DOI Listing
March 2016

On stability issues in deriving multivariable regression models.

Biom J 2015 Jul 15;57(4):531-55. Epub 2014 Dec 15.

Institut für Medizinische Biometrie, Epidemiologie und Informatik, Universitätsmedizin der Johannes-Gutenberg-Universität Mainz, Obere Zahlbacher Straße 69, 55131, Mainz, Germany.

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http://dx.doi.org/10.1002/bimj.201300222DOI Listing
July 2015

Interaction of treatment with a continuous variable: simulation study of power for several methods of analysis.

Stat Med 2014 Nov 22;33(27):4695-708. Epub 2014 Sep 22.

MRC Clinical Trials Unit, University College London, London, WC2B 6NH, U.K.

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http://dx.doi.org/10.1002/sim.6308DOI Listing
November 2014

STRengthening analytical thinking for observational studies: the STRATOS initiative.

Stat Med 2014 Dec 30;33(30):5413-32. Epub 2014 Jul 30.

Center for Medical Biometry and Medical Informatics, Medical Center - University of Freiburg.

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http://doi.wiley.com/10.1002/sim.6265
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http://dx.doi.org/10.1002/sim.6265DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4320765PMC
December 2014

Investigating the prediction ability of survival models based on both clinical and omics data: two case studies.

Stat Med 2014 Dec 9;33(30):5310-29. Epub 2014 Jul 9.

Department of Medical Informatics, Biometry and Epidemiology, Ludwig-Maximilians-Universität of Munich, Germany.

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http://dx.doi.org/10.1002/sim.6246DOI Listing
December 2014

Investigation of continuous effect modifiers in a meta-analysis on higher versus lower PEEP in patients requiring mechanical ventilation--protocol of the ICEM study.

Syst Rev 2014 May 20;3:46. Epub 2014 May 20.

Department of Medical Biometry and Medical Informatics, University Medical Center Freiburg, Freiburg, Germany.

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http://dx.doi.org/10.1186/2046-4053-3-46DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4035853PMC
May 2014

Treatment of primary breast cancer at the surgical unit of the Charité 1984-1998.

Onkologie 2013 22;36(12):727-36. Epub 2013 Nov 22.

Brustzentrum Charité, Medizinische Klinik und Poliklinik, Universitätsmedizin Berlin, Germany.

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http://dx.doi.org/10.1159/000356805DOI Listing
August 2014

Exaggeration of the prognostic effect of Mammostrat: a consequence of poor reporting?

J Clin Oncol 2013 Jul 17;31(21):2760-1. Epub 2013 Jun 17.

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http://dx.doi.org/10.1200/JCO.2013.49.2652DOI Listing
July 2013

Interaction of treatment with a continuous variable: simulation study of significance level for several methods of analysis.

Stat Med 2013 Sep 12;32(22):3788-803. Epub 2013 Apr 12.

Hub for Trials Methodology Research, MRC Clinical Trials Unit and University College London, Aviation House, 125 Kingsway, London WC2B 6NH, U.K.

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http://dx.doi.org/10.1002/sim.5813DOI Listing
September 2013

Comparison between splines and fractional polynomials for multivariable model building with continuous covariates: a simulation study with continuous response.

Stat Med 2013 Jun 3;32(13):2262-77. Epub 2012 Oct 3.

Institute of Medical Biostatistics, Epidemiology and Informatics, University Medical Center of Johannes Gutenberg University Mainz, 55101 Mainz, Germany.

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http://doi.wiley.com/10.1002/sim.5639
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http://dx.doi.org/10.1002/sim.5639DOI Listing
June 2013

Analysing covariates with spike at zero: a modified FP procedure and conceptual issues.

Biom J 2012 Sep 9;54(5):686-700. Epub 2012 Jul 9.

Institute of Public Health, Medical Faculty, University of Heidelberg, Im Neuenheimer Feld 324, 69120 Heidelberg, Germany.

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http://dx.doi.org/10.1002/bimj.201100263DOI Listing
September 2012

Reporting Recommendations for Tumor Marker Prognostic Studies (REMARK): explanation and elaboration.

PLoS Med 2012 29;9(5):e1001216. Epub 2012 May 29.

Centre for Statistics in Medicine, University of Oxford, Oxford, United Kingdom.

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http://dx.doi.org/10.1371/journal.pmed.1001216DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3362085PMC
August 2012

Individual participant data meta-analysis of prognostic factor studies: state of the art?

BMC Med Res Methodol 2012 Apr 24;12:56. Epub 2012 Apr 24.

European Centre for Environment and Human Health, Peninsula College of Medicine and Dentistry, University of Exeter Knowledge Spa Royal Cornwall Hospital Truro, Cornwall TR1 3HD UK.

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http://dx.doi.org/10.1186/1471-2288-12-56DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3413577PMC
April 2012

Stability investigations of multivariable regression models derived from low- and high-dimensional data.

J Biopharm Stat 2011 Nov;21(6):1206-31

Institute of Medical Biometry and Informatics, University Medical Center Freiburg, Freiburg, Germany.

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http://dx.doi.org/10.1080/10543406.2011.629890DOI Listing
November 2011

A new strategy for meta-analysis of continuous covariates in observational studies.

Stat Med 2011 Dec 22;30(28):3341-60. Epub 2011 Sep 22.

IMBI, Freiburg University Medical Center, Stefan-Meier-Str. 26, 79100, Freiburg, Germany.

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http://dx.doi.org/10.1002/sim.4333DOI Listing
December 2011

Use of pretransformation to cope with extreme values in important candidate features.

Biom J 2011 Jul 30;53(4):673-88. Epub 2011 May 30.

Department of Medical Informatics, Biometry and Epidemiology, University of Munich, Marchioninistr. 15, 81377 Munich, Germany.

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http://dx.doi.org/10.1002/bimj.201000189DOI Listing
July 2011

Comparison of procedures to assess non-linear and time-varying effects in multivariable models for survival data.

Biom J 2011 Mar 17;53(2):308-31. Epub 2011 Feb 17.

Department of Medical Biometry and Statistics, Institute of Medical Biometry and Medical Informatics, University Medical Center Freiburg, Stefan-Meier-Strasse 26, 79104 Freiburg, Germany.

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http://dx.doi.org/10.1002/bimj.201000159DOI Listing
March 2011

Added predictive value of high-throughput molecular data to clinical data and its validation.

Brief Bioinform 2011 May 18;12(3):215-29. Epub 2011 Jan 18.

University of Munich, Germany.

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http://dx.doi.org/10.1093/bib/bbq085DOI Listing
May 2011

Modelling continuous exposures with a 'spike' at zero: a new procedure based on fractional polynomials.

Stat Med 2010 May;29(11):1219-27

Hub for Trials Methodology Research, MRC Clinical Trials Unit and University College London, 222 Euston Road, London NW1 2DA, UK.

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http://dx.doi.org/10.1002/sim.3864DOI Listing
May 2010

Selection of important variables and determination of functional form for continuous predictors in multivariable model building.

Stat Med 2007 Dec;26(30):5512-28

Institute of Medical Biometry and Medical Informatics, University Medical Center Freiburg, Stefan-Meier-Strasse 26, 79104 Freiburg, Germany.

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http://dx.doi.org/10.1002/sim.3148DOI Listing
December 2007

A new proposal for multivariable modelling of time-varying effects in survival data based on fractional polynomial time-transformation.

Biom J 2007 Jun;49(3):453-73

Institute of Medical Biometry and Medical Informatics, University Hospital of Freiburg, Stefan-Meier-Strasse 26, 79104 Freiburg, Germany.

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http://dx.doi.org/10.1002/bimj.200610328DOI Listing
June 2007

Modelling to extract more information from clinical trials data: On some roles for the bootstrap.

Stat Med 2007 Nov;26(27):4989-5001

Institute of Medical Biometry and Medical Informatics, University Medical Center Freiburg, Stefan-Meier-Strasse 26, 79104 Freiburg, Germany.

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http://dx.doi.org/10.1002/sim.2954DOI Listing
November 2007

REporting recommendations for tumor MARKer prognostic studies (REMARK).

Breast Cancer Res Treat 2006 Nov 24;100(2):229-35. Epub 2006 Aug 24.

Biometric Research Branch, DCTD, National Cancer Institute, Room 8126, Executive Plaza North, 6130 Executive Boulevard, Bethesda, MD 20892-7434, USA.

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November 2006

REporting recommendations for tumor MARKer prognostic studies (REMARK).

Nat Clin Pract Urol 2005 Aug;2(8):416-22

National Cancer Institute, Biometric Research Branch, Bethesda, MD 20892-7434, USA.

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August 2005

Dichotomizing continuous predictors in multiple regression: a bad idea.

Stat Med 2006 Jan;25(1):127-41

MRC Clinical Trials Unit, 222 Euston Road, London NW1 2DA, UK.

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http://dx.doi.org/10.1002/sim.2331DOI Listing
January 2006

Reporting recommendations for tumor marker prognostic studies.

J Clin Oncol 2005 Dec 19;23(36):9067-72. Epub 2005 Sep 19.

Biometric Research Branch, National Cancer Institute, Bethesda, MD, USA.

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December 2005

REporting recommendations for tumor MARKer prognostic studies (REMARK).

Nat Clin Pract Oncol 2005 Aug;2(8):416-22

National Cancer Institute, Biometric Research Branch, DCTD, Room 8126, Executive Plaza North, MSC 7434, 6130 Executive Boulevard, Bethesda, MD 20892-7434, USA.

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August 2005

Reporting recommendations for tumor marker prognostic studies (REMARK).

J Natl Cancer Inst 2005 Aug;97(16):1180-4

Biometric Research Branch, National Cancer Institute, Executive Plaza North, 6130 Executive Blvd., Bethesda, MD 20892-7434, USA.

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August 2005

REporting recommendations for tumour MARKer prognostic studies (REMARK).

Eur J Cancer 2005 Aug;41(12):1690-6

National Cancer Institute, Biometric Research Branch, DCTD, Room 8126, Executive Plaza North, MSC 7434, 6130 Executive Boulevard, Bethesda, MD 20892-7434, USA.

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August 2005

Prognostic factors. Confusion caused by bad quality design, analysis and reporting of many studies.

Authors:
Willi Sauerbrei

Adv Otorhinolaryngol 2005 ;62:184-200

Abteilung Medizinische Biometrie und Statistik, Institut für Medizinische Biometrie und Medizinische Informatik, Universitätsklinikum Freiburg, Freiburg, Deutschland.

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http://dx.doi.org/10.1159/000082508DOI Listing
January 2005

A new approach to modelling interactions between treatment and continuous covariates in clinical trials by using fractional polynomials.

Stat Med 2004 Aug;23(16):2509-25

MRC Clinical Trials Unit, 222 Euston Road, London NW1 2DA, UK.

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http://dx.doi.org/10.1002/sim.1815DOI Listing
August 2004

Confidence intervals for the effect of a prognostic factor after selection of an 'optimal' cutpoint.

Stat Med 2004 Jun;23(11):1701-13

Institute of Medical Biometry and Medical Informatics, University Hospital Freiburg, Stefan-Meier-Strasse 26, Freiburg D-79104, Germany.

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http://dx.doi.org/10.1002/sim.1611DOI Listing
June 2004

Assessment of breast cancer vascularisation by Doppler ultrasound as a prognostic factor of survival.

Oncol Rep 2004 Apr;11(4):905-10

Department of Obstetrics and Gynaecology, Freiburg University Medical Centre, 79106 Freiburg, Germany.

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April 2004

A new measure of prognostic separation in survival data.

Stat Med 2004 Mar;23(5):723-48

Cancer Division, MRC Clinical Trials Unit, London NW1 2DA, UK.

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http://dx.doi.org/10.1002/sim.1621DOI Listing
March 2004

Tumor stage and early mortality for surgical resections in lung cancer.

Langenbecks Arch Surg 2003 Apr 22;388(2):116-21. Epub 2003 Feb 22.

Department of Thoracic Surgery, University Hospital, 79106, Freiburg, Germany.

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April 2003

Multivariate analysis of prognostic factors in patients with glioblastoma.

Strahlenther Onkol 2003 Jan;179(1):8-15

Department of Radiotherapy, Radiologic University Hospital, Freiburg i. Br., Germany.

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http://dx.doi.org/10.1007/s00066-003-1004-5DOI Listing
January 2003

Multivariate analysis of prognostic factors in patients with glioblastoma.

Strahlenther Onkol 2003 Jan;179(1):8-15

Department of Radiotherapy, Radiologic University Hospital, Freiburg i. Br., Germany.

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January 2003