Publications by authors named "Willem A L van Otterlo"

55Publications

Overcoming synthetic challenges in targeting coenzyme A biosynthesis with the antimicrobial natural product CJ-15,801.

Medchemcomm 2019 Dec 17;10(12):2118-2125. Epub 2019 Oct 17.

Department of Biochemistry , Stellenbosch University , Private Bag X1 , Matieland 7602 , South Africa . Email:

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http://dx.doi.org/10.1039/c9md00312fDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7069524PMC
December 2019

Analysis of the Combinatory Effects of Novel Aminonaphthoquinone Derivatives and Curcumin on Breast Cancer Progression.

Anticancer Res 2020 Jan;40(1):229-238

Department of Physiology, Nelson Mandela University, Port Elizabeth, South Africa

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http://dx.doi.org/10.21873/anticanres.13944DOI Listing
January 2020

1-Aryl-3-(4-methoxybenzyl)ureas as potentially irreversible glycogen synthase kinase 3 inhibitors: Synthesis and biological evaluation.

Bioorg Med Chem Lett 2019 07 29;29(13):1597-1600. Epub 2019 Apr 29.

Department of Chemistry and Polymer Science, Stellenbosch University, Stellenbosch 7602, South Africa. Electronic address:

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http://dx.doi.org/10.1016/j.bmcl.2019.04.049DOI Listing
July 2019

Aryl Substituted Benzimidazolones as Potent HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors.

ACS Med Chem Lett 2019 Feb 17;10(2):196-202. Epub 2019 Jan 17.

Department of Chemistry, Emory University, 1515 Dickey Drive, Atlanta, Georgia 30322, United States.

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http://dx.doi.org/10.1021/acsmedchemlett.8b00549DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6378675PMC
February 2019

The Rigidins: Isolation, Bioactivity, and Total Synthesis-Novel Pyrrolo[2,3-d]Pyrimidine Analogues Using Multicomponent Reactions.

Alkaloids Chem Biol 2018;79:191-220. Epub 2018 Feb 6.

Department of Chemistry and Polymer Science, University of Stellenbosch, Matieland, Stellenbosch, South Africa. Electronic address:

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http://dx.doi.org/10.1016/bs.alkal.2017.12.003DOI Listing
June 2018

Developing Pantetheinase-Resistant Pantothenamide Antibacterials: Structural Modification Impacts on PanK Interaction and Mode of Action.

ACS Infect Dis 2018 05 23;4(5):736-743. Epub 2018 Jan 23.

Department of Biochemistry , Stellenbosch University , Private Bag X1 , Matieland , 7602 , South Africa.

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http://dx.doi.org/10.1021/acsinfecdis.7b00240DOI Listing
May 2018

Evaluation of the Effects of Aminonaphthoquinone Derivatives in Combination with Curcumin Against ER-positive Breast Cancer and Related Tumours.

Anticancer Res 2017 12;37(12):6749-6759

Department of Biochemistry & Microbiology, Nelson Mandela Metropolitan University, Port Elizabeth, South Africa

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http://dx.doi.org/10.21873/anticanres.12135DOI Listing
December 2017

Sarniensine, a mesembrine-type alkaloid isolated from Nerine sarniensis, an indigenous South African Amaryllidaceae, with larvicidal and adulticidal activities against Aedes aegypti.

Fitoterapia 2017 Jan 15;116:34-38. Epub 2016 Nov 15.

Department of Chemical Sciences, University of Naples "Federico II", Complesso Universitario Monte S. Angelo, Via Cintia 4, 80126 Napoli, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.fitote.2016.11.007DOI Listing
January 2017

Application of the Huisgen cycloaddition and 'click' reaction toward various 1,2,3-triazoles as HIV non-nucleoside reverse transcriptase inhibitors.

Bioorg Med Chem Lett 2016 Aug 28;26(15):3700-4. Epub 2016 May 28.

Department of Chemistry and Polymer Science, Stellenbosch University, Private Bag X1, Matieland 7602, South Africa. Electronic address:

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http://dx.doi.org/10.1016/j.bmcl.2016.05.082DOI Listing
August 2016

Synthesis and in vitro growth inhibitory activity of novel silyl- and trityl-modified nucleosides.

Bioorg Med Chem 2016 06 20;24(12):2716-24. Epub 2016 Apr 20.

Molecular Sciences Institute, School of Chemistry, University of the Witwatersrand, PO Wits, Johannesburg 2050, South Africa; Department of Chemistry and Polymer Science, Stellenbosch University, Stellenbosch, Matieland 7602, South Africa. Electronic address:

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http://dx.doi.org/10.1016/j.bmc.2016.04.036DOI Listing
June 2016

Spacer Length: A Determining Factor in the Design of Galactosyl Ligands for Hepatoma Cell-Specific Liposomal Gene Delivery.

Curr Drug Deliv 2016 ;13(6):935-45

Non-viral Gene Delivery Laboratory, Discipline of Biochemistry, Westville campus, University of KwaZulu-Natal, Private Bag X54001, Durban, 4000 South Africa.

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http://dx.doi.org/10.2174/1567201813666160224123450DOI Listing
May 2017

Novel indole sulfides as potent HIV-1 NNRTIs.

Bioorg Med Chem Lett 2016 Mar 4;26(6):1580-1584. Epub 2016 Feb 4.

Department of Chemistry and Polymer Science, Stellenbosch University, Private Bag X1, 7602 Matieland, Western Cape, South Africa. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S0960894X163010
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http://dx.doi.org/10.1016/j.bmcl.2016.02.006DOI Listing
March 2016

Design, Synthesis, and Evaluation of Novel Ferroquine and Phenylequine Analogues as Potential Antiplasmodial Agents.

ChemMedChem 2015 Dec 8;10(12):2099-110. Epub 2015 Oct 8.

Department of Chemistry and Polymer Science, Stellenbosch University, Private Bag X1, Matieland, 7602, South Africa.

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http://dx.doi.org/10.1002/cmdc.201500349DOI Listing
December 2015

In vitro antiplasmodial activity of triazole-linked chloroquinoline derivatives synthesized from 7-chloro-N-(prop-2-yn-1-yl)quinolin-4-amine.

Bioorg Med Chem 2015 Aug 27;23(15):4163-4171. Epub 2015 Jun 27.

Department of Chemistry and Polymer Science, University of Stellenbosch, Private Bag X1, Matieland 7602, South Africa. Electronic address:

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http://dx.doi.org/10.1016/j.bmc.2015.06.044DOI Listing
August 2015

Covalent-Allosteric Kinase Inhibitors.

Angew Chem Int Ed Engl 2015 Aug 25;54(35):10313-6. Epub 2015 Jun 25.

Technische Universität Dortmund, Fakultät für Chemie und Chemische Biologie, Otto-Hahn-Strasse 6, 44227 Dortmund (Germany).

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http://dx.doi.org/10.1002/anie.201502142DOI Listing
August 2015

Isomerization of allylbenzenes.

Chem Rev 2015 Jun 20;115(11):5462-569. Epub 2015 May 20.

†Department of Chemistry and Polymer Science, Stellenbosch University, Private Bag X1, Matieland 7602, South Africa.

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http://pubs.acs.org/doi/10.1021/acs.chemrev.5b00052
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http://dx.doi.org/10.1021/acs.chemrev.5b00052DOI Listing
June 2015

Toward a Cancer Drug of Fungal Origin.

Med Res Rev 2015 Sep 8;35(5):937-67. Epub 2015 Apr 8.

Laboratorie de Cancérologie et de Toxicologie Expérimentale, Faculté de Pharmacie, Université Libre de Bruxelles (ULB), Brussels, Belgium.

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http://dx.doi.org/10.1002/med.21348DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4529806PMC
September 2015

Synthesis of novel triazole-linked mefloquine derivatives: biological evaluation against Plasmodium falciparum.

Bioorg Med Chem Lett 2014 Dec 13;24(23):5466-9. Epub 2014 Oct 13.

Department of Chemistry and Polymer Science, University of Stellenbosch, Private Bag X1, Matieland 7602, South Africa.

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http://dx.doi.org/10.1016/j.bmcl.2014.10.015DOI Listing
December 2014

Stealth lipoplex decorated with triazole-tethered galactosyl moieties: a strong hepatotropic gene vector.

Biotechnol Lett 2015 Mar 29;37(3):567-75. Epub 2014 Nov 29.

Non-viral Gene Delivery Laboratory, Discipline of Biochemistry, University of KwaZulu-Natal, Durban, South Africa,

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http://dx.doi.org/10.1007/s10529-014-1729-5DOI Listing
March 2015

Novel indole based NNRTIs with improved potency against wild type and resistant HIV.

Bioorg Med Chem Lett 2014 Sep 13;24(18):4376-4380. Epub 2014 Aug 13.

Department of Chemistry and Polymer Science, Stellenbosch University, Private Bag X1, 7602 Matieland, Western Cape, South Africa. Electronic address:

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http://dx.doi.org/10.1016/j.bmcl.2014.08.020DOI Listing
September 2014

C1,C2-ether derivatives of the Amaryllidaceae alkaloid lycorine: retention of activity of highly lipophilic analogues against cancer cells.

Bioorg Med Chem Lett 2014 Feb 24;24(3):923-7. Epub 2013 Dec 24.

Department of Chemistry and Biochemistry, Texas State University, San Marcos, TX 78666, USA. Electronic address:

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http://dx.doi.org/10.1016/j.bmcl.2013.12.073DOI Listing
February 2014

Overcoming compound fluorescence in the FLiK screening assay with red-shifted fluorophores.

J Am Chem Soc 2013 Jun 24;135(22):8400-8. Epub 2013 May 24.

Chemical Genomics Centre of the Max-Planck-Society , Otto-Hahn-Strasse 15, 44137 Dortmund, Germany.

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http://dx.doi.org/10.1021/ja403074jDOI Listing
June 2013

Novel Cyclopropyl-Indole Derivatives as HIV Non-Nucleoside Reverse Transcriptase Inhibitors.

ACS Med Chem Lett 2012 Jun 2;3(6):470-5. Epub 2012 May 2.

Department of Chemistry and Polymer Science, Stellenbosch University , Western Cape, South Africa.

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http://dx.doi.org/10.1021/ml3000462DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4025642PMC
June 2012

In search of a treatment for HIV--current therapies and the role of non-nucleoside reverse transcriptase inhibitors (NNRTIs).

Chem Soc Rev 2012 Jul 22;41(13):4657-70. Epub 2012 May 22.

Molecular Sciences Institute, School of Chemistry, University of the Witwatersrand, Private Bag 3, PO WITS, 2050, South Africa.

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http://dx.doi.org/10.1039/c2cs35058kDOI Listing
July 2012

Composites of polyvinyl alcohol and carbon (coils, undoped and nitrogen doped multiwalled carbon nanotubes) as ethanol, methanol and toluene vapor sensors.

J Nanosci Nanotechnol 2011 Nov;11(11):10211-8

Departamento de Física, Universidade Federal do Paraná, Caixa Postal 19044, 81531-990 Curitiba, Brazil.

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http://dx.doi.org/10.1166/jnn.2011.4991DOI Listing
November 2011

Structure-based design, synthesis and biological evaluation of N-pyrazole, N'-thiazole urea inhibitors of MAP kinase p38α.

Eur J Med Chem 2012 Feb 18;48:1-15. Epub 2011 Nov 18.

Chemical Genomics Centre of the Max Planck Society, Otto-Hahn-Strasse 15, D-44227 Dortmund, Germany.

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http://dx.doi.org/10.1016/j.ejmech.2011.11.019DOI Listing
February 2012

Design and evaluation of fragment-like estrogen receptor tetrahydroisoquinoline ligands from a scaffold-detection approach.

J Med Chem 2011 Apr 7;54(7):2005-11. Epub 2011 Mar 7.

Laboratory of Chemical Biology, Department of Biomedical Engineering, Technische Universiteit Eindhoven, Den Dolech 2, 5612AZ Eindhoven, The Netherlands.

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http://dx.doi.org/10.1021/jm1011116DOI Listing
April 2011

CAN-mediated oxidations for the synthesis of xanthones and related products.

J Org Chem 2010 Dec 18;75(24):8701-4. Epub 2010 Nov 18.

Molecular Sciences Institute, School of Chemistry, University of the Witwatersrand, PO Wits 2050, South Africa.

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http://dx.doi.org/10.1021/jo101873vDOI Listing
December 2010

The synthesis of 2- and 3-aryl indoles and 1,3,4,5-tetrahydropyrano[4,3-b]indoles and their antibacterial and antifungal activity.

Bioorg Med Chem Lett 2009 Sep 22;19(17):4948-51. Epub 2009 Jul 22.

Molecular Sciences Institute, School of Chemistry, University of the Witwatersrand, South Africa.

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http://dx.doi.org/10.1016/j.bmcl.2009.07.091DOI Listing
September 2009

Metathesis in the synthesis of aromatic compounds.

Chem Rev 2009 Aug;109(8):3743-82

Molecular Sciences Institute, School of Chemistry, University of the Witwatersrand, PO Wits 2050, South Africa.

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http://dx.doi.org/10.1021/cr900178pDOI Listing
August 2009

Bioactivity-guided mapping and navigation of chemical space.

Nat Chem Biol 2009 Aug 28;5(8):585-92. Epub 2009 Jun 28.

Max-Planck-Institut für Molekulare Physiologie, Abteilung Chemische Biologie, Dortmund, Germany.

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http://dx.doi.org/10.1038/nchembio.188DOI Listing
August 2009

Efficient nucleic acid transduction with lipoplexes containing novel piperazine- and polyamine-conjugated cholesterol derivatives.

Bioorg Med Chem Lett 2009 Jan 6;19(1):100-3. Epub 2008 Nov 6.

Department of Molecular Medicine and Haematology, Antiviral Gene Therapy Research Unit, University of the Witwatersrand Medical School, Private Bag 3, WITS, South Africa.

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http://dx.doi.org/10.1016/j.bmcl.2008.11.009DOI Listing
January 2009

Bidirectional racemic synthesis of the biologically active quinone cardinalin 3.

Org Biomol Chem 2007 Aug 26;5(15):2433-40. Epub 2007 Jun 26.

Molecular Sciences Institute, School of Chemistry, University of the Witwatersrand, PO Wits 2050, South Africa.

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http://dx.doi.org/10.1039/b707187fDOI Listing
August 2007

Metathesis reactions for the synthesis of ring-fused carbazoles.

J Org Chem 2005 Dec;70(25):10474-81

Molecular Sciences Institute, School of Chemistry, University of the Witwatersrand, P.O. Wits, 2050 South Africa.

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http://dx.doi.org/10.1021/jo051826sDOI Listing
December 2005

Phenolic P2/P3 core motif as thrombin inhibitors--design, synthesis, and X-ray co-crystal structure.

Bioorg Med Chem Lett 2006 Feb 15;16(4):1032-6. Epub 2005 Nov 15.

Department of Chemistry, Université de Montréal, C.P. 6128, Succ. Centre-Ville, Montréal, PQ, Canada H3C 3J7.

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http://dx.doi.org/10.1016/j.bmcl.2005.10.082DOI Listing
February 2006

The synthesis of angularly fused polyaromatic compounds by using a light-assisted, base-mediated cyclization reaction.

Org Biomol Chem 2004 Dec 4;2(23):3504-9. Epub 2004 Nov 4.

Molecular Sciences Institute, School of Chemistry, University of the Witwatersrand, PO Wits, 2050, South Africa.

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http://dx.doi.org/10.1039/b412932fDOI Listing
December 2004