Publications by authors named "Will Thompson"

100Publications

The effect of pathogen inactivation on cryoprecipitate: a functional and quantitative evaluation.

Blood Transfus 2020 Aug 6. Epub 2020 Aug 6.

Department of Anesthesiology, Duke University Medical Center, Durham, NC, United States of America.

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http://dx.doi.org/10.2450/2020.0077-20DOI Listing
August 2020

Quantitative proteomics links the LRRC59 interactome to mRNA translation on the ER membrane.

Mol Cell Proteomics 2020 Aug 11. Epub 2020 Aug 11.

Department of Cell Biology, Duke University School of Medicine, United States

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http://dx.doi.org/10.1074/mcp.RA120.002228DOI Listing
August 2020

Acylcarnitine metabolomic profiles inform clinically-defined major depressive phenotypes.

J Affect Disord 2020 Mar 30;264:90-97. Epub 2019 Nov 30.

Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, NC, United States; Department of Medicine, Duke University, Durham, NC, United States; Duke Institute of Brain Sciences, Duke University, Durham, NC, United States. Electronic address:

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http://dx.doi.org/10.1016/j.jad.2019.11.122DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7024064PMC
March 2020

Reprioritization of biofilm metabolism is associated with nutrient adaptation and long-term survival of .

NPJ Biofilms Microbiomes 2019;5(1):33. Epub 2019 Nov 5.

1The Abigail Wexner Research Institute at Nationwide Children's Hospital, Center for Microbial Pathogenesis, 700 Children's Drive, Columbus, OH 43205 USA.

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http://dx.doi.org/10.1038/s41522-019-0105-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6831627PMC
June 2020

Pathogen Evasion of Chemokine Response Through Suppression of CXCL10.

Front Cell Infect Microbiol 2019 7;9:280. Epub 2019 Aug 7.

Department of Molecular Genetics and Microbiology, School of Medicine, Duke University, Durham, NC, United States.

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http://dx.doi.org/10.3389/fcimb.2019.00280DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6693555PMC
July 2020

Metabolomic Patterns in Adolescents With Mild to Moderate CKD.

Kidney Int Rep 2019 May 28;4(5):720-723. Epub 2019 Jan 28.

Department of Pathology and Laboratory Medicine, Ann and Robert H. Lurie Children's Hospital of Chicago, Chicago, Illinois, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S24680249193003
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http://dx.doi.org/10.1016/j.ekir.2019.01.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6506724PMC
May 2019

Respiratory Phenomics across Multiple Models of Protein Hyperacylation in Cardiac Mitochondria Reveals a Marginal Impact on Bioenergetics.

Cell Rep 2019 02;26(6):1557-1572.e8

Duke Molecular Physiology Institute and Sarah W. Stedman Nutrition and Metabolism Center, Duke University Medical Center, Durham, NC 27701, USA; Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27710, USA; Department of Medicine, Division of Endocrinology, Metabolism, and Nutrition, Duke University Medical Center, Durham, NC 27710, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2019.01.057DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6478502PMC
February 2019

CoA synthase regulates mitotic fidelity via CBP-mediated acetylation.

Nat Commun 2018 03 12;9(1):1039. Epub 2018 Mar 12.

Department of Molecular Genetics and Microbiology, Center for Genomic and Computational Biology, Duke University School of Medicine, Durham, NC, 27710, USA.

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http://dx.doi.org/10.1038/s41467-018-03422-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5847545PMC
March 2018

Stem cells enhance reperfusion following ischemia: Validation using laser speckle imaging in predicting tissue repair.

Laryngoscope 2018 06 5;128(6):E198-E205. Epub 2018 Feb 5.

Department of Molecular and Cellular Physiology, LSU Health Sciences Center, Shreveport, Louisiana, U.S.A.

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http://dx.doi.org/10.1002/lary.27110DOI Listing
June 2018

Harmonizing lipidomics: NIST interlaboratory comparison exercise for lipidomics using SRM 1950-Metabolites in Frozen Human Plasma.

J Lipid Res 2017 12 6;58(12):2275-2288. Epub 2017 Oct 6.

Lipidomics Core Facility and Department of Pathology, Wayne State University, Detroit, MI.

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http://www.jlr.org/lookup/doi/10.1194/jlr.M079012
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http://dx.doi.org/10.1194/jlr.M079012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5711491PMC
December 2017

Impact of 27-hydroxylase (CYP27A1) and 27-hydroxycholesterol in breast cancer.

Endocr Relat Cancer 2017 07 25;24(7):339-349. Epub 2017 Apr 25.

Division of Oncology and PathologyDepartment of Clinical Sciences, Lund, Lund University, Sweden

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https://erc.bioscientifica.com/view/journals/erc/24/7/339.xm
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http://dx.doi.org/10.1530/ERC-16-0533DOI Listing
July 2017

Investigating the Genetic Architecture of the PR Interval Using Clinical Phenotypes.

Circ Cardiovasc Genet 2017 Apr;10(2)

From the Department of Medicine (J.D.M., M.B.S., Q.S.W., C.M.S., J.C.D., D.M.R.), Vanderbilt Epidemiology Center (T.L.E.), Department of Biomedical Informatics (L.B., J.C.D., D.M.R.), Department of Pharmacology (D.M.R.), Vanderbilt University, Nashville, TN; Division of Cardiology, University of Illinois at Chicago (D.D.); Essentia Institute of Rural Health, Duluth, MN (C.A.M.); Center for Biomedical Research Informatics, NorthShore University Health System, Evanston, IL (W.T.); School of Medicine (C.G.C.), School of Public Health (C.G.C.), and School of Nursing (C.G.C.), Johns Hopkins University, Baltimore, MD; Division of Medical Genetics, Department of Medicine (G.P.J.), Department of Genome Sciences (G.P.J.), Department of Biomedical Informatics (D.R.C.), Department of Medical Education (D.R.C.), University of Washington; Group Health Research Institute, Seattle, WA (E.B.L.); Division of Cardiovascular Diseases, Mayo Clinic, Rochester, MN (I.J.K.); Center for Genetic Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL (J.A.P.); Biomedical Informatics Research Center (P.L.P.), Center for Human Genetics (M.H.B., J.G.L.), Marshfield Clinic Research Foundation, WI; and Department of Epidemiology and Biostatistics, University of California, San Francisco (J.S.W.).

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http://dx.doi.org/10.1161/CIRCGENETICS.116.001482DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5434456PMC
April 2017

SIRT4 Is a Lysine Deacylase that Controls Leucine Metabolism and Insulin Secretion.

Cell Metab 2017 Apr;25(4):838-855.e15

Duke Molecular Physiology Institute and Sarah W. Stedman Nutrition and Metabolism Center, Duke University Medical Center, Durham, NC 27701, USA; Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27710, USA; Department of Medicine, Division of Endocrinology, Metabolism, and Nutrition, Duke University Medical Center, Durham, NC 27710, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2017.03.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5444661PMC
April 2017

A Class of Reactive Acyl-CoA Species Reveals the Non-enzymatic Origins of Protein Acylation.

Cell Metab 2017 Apr;25(4):823-837.e8

Sarah W. Stedman Nutrition and Metabolism Center, Duke Molecular Physiology Institute, Duke University Medical Center, Durham, NC 27710, USA; Division of Endocrinology, Metabolism, and Nutrition, Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA; Department of Pharmacology & Cancer Biology, Duke University Medical Center, Durham, NC 27710, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2017.03.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5399522PMC
April 2017

Proteomic Analysis of Primary Human Airway Epithelial Cells Exposed to the Respiratory Toxicant Diacetyl.

J Proteome Res 2017 02 9;16(2):538-549. Epub 2017 Jan 9.

National Institute of Environmental Health Sciences , Research Triangle Park, North Carolina 27709, United States.

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http://dx.doi.org/10.1021/acs.jproteome.6b00672DOI Listing
February 2017

Defining a Contemporary Ischemic Heart Disease Genetic Risk Profile Using Historical Data.

Circ Cardiovasc Genet 2016 Dec 25;9(6):521-530. Epub 2016 Oct 25.

From the Department of Medicine (J.D.M., S.L.v.D., Q.S.W., C.M.S., J.C.D., D.M.R.), Department of Pediatrics (S.L.v.D.), Vanderbilt Epidemiology Center (T.L.E.), Biomedical Informatics (L.B., J.C.D., D.M.R.), and Department of Pharmacology (D.M.R.), Vanderbilt University, Nashville, TN; Essentia Institute of Rural Health, Duluth, MN (C.A.M.); Center for Biomedical Research Informatics, North Shore University Health System, Evanston, IL (W.T.); Department of Health Policy and Management Schools of Medicine, Public Health, and Nursing, Johns Hopkins University, Baltimore, MD (C.G.C.); Departments of Medicine (Medical Genetics) and Genome Sciences (G.P.J.) and Departments of Biomedical Informatics and Medical Education (D.R.C.), University of Washington, Seattle; Group Health Research Institute, Seattle, WA (E.B.L.); Division of Cardiovascular Diseases, Mayo Clinic, Rochester, MN (I.J.K.); Center for Genetic Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL (J.A.P.); and Biomedical Informatics Research Center (P.L.P., J.G.L.) and Center for Human Genetics (M.H.B.), Marshfield Clinic Research Foundation, WI.

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http://dx.doi.org/10.1161/CIRCGENETICS.116.001530DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5177499PMC
December 2016

The Acetyl Group Buffering Action of Carnitine Acetyltransferase Offsets Macronutrient-Induced Lysine Acetylation of Mitochondrial Proteins.

Cell Rep 2016 Jan 31;14(2):243-54. Epub 2015 Dec 31.

Sarah W. Stedman Nutrition and Metabolism Center, Duke Molecular Physiology Institute, Duke University, Durham, NC 27701, USA; Department of Medicine, Duke University, Durham, NC 27701, USA; Department of Pharmacology and Cancer Biology, Duke University, Durham, NC 27701, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2015.12.030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4754083PMC
January 2016

Comprehensive Proteomic and Metabolomic Signatures of Nontypeable Haemophilus influenzae-Induced Acute Otitis Media Reveal Bacterial Aerobic Respiration in an Immunosuppressed Environment.

Mol Cell Proteomics 2016 Mar 28;15(3):1117-38. Epub 2015 Dec 28.

From the ‡The Center for Microbial Pathogenesis, The Research Institute at Nationwide Children's Hospital, Columbus, Ohio 43205; §The Center for Microbial Interface Biology and Department of Pediatrics, The Ohio State University, Columbus, Ohio 43210;

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http://dx.doi.org/10.1074/mcp.M115.052498DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4813693PMC
March 2016

Chlamydia trachomatis Infection Leads to Defined Alterations to the Lipid Droplet Proteome in Epithelial Cells.

PLoS One 2015 24;10(4):e0124630. Epub 2015 Apr 24.

Department of Molecular Genetics and Microbiology and Center for Microbial Pathogenesis, Duke University Medical Center, Durham, North Carolina, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0124630PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4409204PMC
January 2016

Comprehensive profiling of amino acid response uncovers unique methionine-deprived response dependent on intact creatine biosynthesis.

PLoS Genet 2015 Apr 7;11(4):e1005158. Epub 2015 Apr 7.

Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, North Carolina, United States of America; Center for Genomic and Computational Biology, Duke University Medical Center, Durham, North Carolina, United States of America.

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http://dx.doi.org/10.1371/journal.pgen.1005158DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4388453PMC
April 2015

Cerebrospinal fluid proteomics in children during induction for acute lymphoblastic leukemia: A pilot study.

Pediatr Blood Cancer 2015 Jul 23;62(7):1190-4. Epub 2015 Mar 23.

Division of Pediatric Hematology/Oncology, University of North Carolina, Chapel Hill, North Carolina.

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http://dx.doi.org/10.1002/pbc.25420DOI Listing
July 2015

An assessment of human gastric fluid composition as a function of PPI usage.

Physiol Rep 2015 Jan 27;3(1). Epub 2015 Jan 27.

Department of Surgery, Duke University Medical Center, Durham, North Carolina Department of Immunology, Duke University Medical Center, Durham, North Carolina.

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http://dx.doi.org/10.14814/phy2.12269DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4387745PMC
January 2015

Optimizing Urine Processing Protocols for Protein and Metabolite Detection.

J Proteomics Bioinform 2015;2015(Suppl 14). Epub 2015 Dec 21.

Division of Gynecologic Oncology; Department of Obstetrics & Gynecology, Duke University, Durham, NC, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4872872PMC
December 2015

Quantitative proteomics of bronchoalveolar lavage fluid in idiopathic pulmonary fibrosis.

J Proteome Res 2015 Feb 14;14(2):1238-49. Epub 2015 Jan 14.

Pulmonary, Allergy and Critical Care Medicine, ‡Duke Proteomics and Metabolomics Shared Resource, §Department of Surgery, Duke University Medical Center , Durham, North Carolina 27710, United States , and.

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http://dx.doi.org/10.1021/pr501149mDOI Listing
February 2015

Proteomic differences between male and female anterior cruciate ligament and patellar tendon.

PLoS One 2014 12;9(5):e96526. Epub 2014 May 12.

Department of Orthopaedic Surgery, Duke University Medical Center, Durham, North Carolina, United States of America; Department of Biomedical Engineering, Duke University Medical Center, Durham, North Carolina, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0096526PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4018326PMC
January 2015

Small ubiquitin-like modifier 3-modified proteome regulated by brain ischemia in novel small ubiquitin-like modifier transgenic mice: putative protective proteins/pathways.

Stroke 2014 Apr 25;45(4):1115-22. Epub 2014 Feb 25.

From the Department of Anesthesiology (W.Y., H.S., L.W., P.M., X.L., W.P.), Proteomics Core Facility (J.W.T., M.A.M.), and Department of Neurobiology (S.Z.), Duke University Medical Center, Durham, NC; and Department of Neurosurgery, The Fifth Central Hospital of Tianjin, Tianjin, China (X.L.).

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http://dx.doi.org/10.1161/STROKEAHA.113.004315DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3966925PMC
April 2014

Characterization of the ubiquitin-modified proteome regulated by transient forebrain ischemia.

J Cereb Blood Flow Metab 2014 Mar 4;34(3):425-32. Epub 2013 Dec 4.

Multidisciplinary Neuroprotection Laboratories, Department of Anesthesiology, Duke University Medical Center, Durham, North Carolina, USA.

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http://dx.doi.org/10.1038/jcbfm.2013.210DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3948117PMC
March 2014

Identification of deacetylase substrates with the biotin switch approach.

Methods Mol Biol 2013 ;1077:133-48

Duke Proteomics Core Facility, Institute for Genome Sciences and Policy, Duke University Medical Center, Durham, NC, USA.

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http://dx.doi.org/10.1007/978-1-62703-637-5_9DOI Listing
April 2014

Longitudinal study of differential protein expression in an Alzheimer's mouse model lacking inducible nitric oxide synthase.

J Proteome Res 2013 Oct 18;12(10):4462-77. Epub 2013 Sep 18.

Department of Medicine/Neurology, ‡Institute for Genome Sciences & Policy, School of Medicine, and §Division of Pulmonary, Allergy and Critical Care Medicine, Duke University Medical Center, Duke University , Durham, North Carolina 27710, United States.

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http://dx.doi.org/10.1021/pr4005103DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3875406PMC
October 2013

Proteomic identification of unique photoreceptor disc components reveals the presence of PRCD, a protein linked to retinal degeneration.

J Proteome Res 2013 Jun 24;12(6):3010-8. Epub 2013 May 24.

Albert Eye Research Institute, 2Institute for Genome Sciences & Policy, Duke University School of Medicine, Durham, North Carolina 27710, United States.

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http://dx.doi.org/10.1021/pr4003678DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3771658PMC
June 2013

Proteomic analysis of human bronchoalveolar lavage fluid after subsgemental exposure.

J Proteome Res 2013 May 24;12(5):2194-205. Epub 2013 Apr 24.

Division of Pulmonary, Allergy and Critical Care Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA.

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http://dx.doi.org/10.1021/pr400066gDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3822014PMC
May 2013

Automated, reproducible, titania-based phosphopeptide enrichment strategy for label-free quantitative phosphoproteomics.

J Biomol Tech 2013 Apr;24(1):8-16

Duke Proteomics Core Facility, Institute for Genome Sciences & Policy, Duke University School of Medicine, Durham, NC 27708, USA.

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http://dx.doi.org/10.7171/jbt.13-2401-002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3533261PMC
April 2013

Proteomic analysis of the NOS2 interactome in human airway epithelial cells.

Nitric Oxide 2013 Nov 21;34:37-46. Epub 2013 Feb 21.

Division of Pulmonary, Allergy and Critical Care Medicine, Duke University Medical Centers, Durham, NC 27710, United States. Electronic address:

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http://dx.doi.org/10.1016/j.niox.2013.02.079DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3769490PMC
November 2013

Proteomic analysis of ERK1/2-mediated human sickle red blood cell membrane protein phosphorylation.

Clin Proteomics 2013 Jan 3;10(1). Epub 2013 Jan 3.

Division of Hematology and Duke Comprehensive Sickle Cell Center, Department of Medicine, Duke University Medical Center, Durham, NC, USA.

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http://dx.doi.org/10.1186/1559-0275-10-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3558407PMC
January 2013

NADPH:quinone oxidoreductase 1 regulates host susceptibility to ozone via isoprostane generation.

J Biol Chem 2013 Feb 28;288(7):4681-91. Epub 2012 Dec 28.

Division of Pediatric Pulmonary and Sleep Medicine, Department of Pediatrics, Duke University Medical Center, Durham, North Carolina 27710, USA.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M112.438440
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http://dx.doi.org/10.1074/jbc.M112.438440DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3576073PMC
February 2013

Proteomic analysis of an unculturable bacterial endosymbiont (Blochmannia) reveals high abundance of chaperonins and biosynthetic enzymes.

J Proteome Res 2013 Feb 27;12(2):704-18. Epub 2012 Dec 27.

Institute for Genome Sciences and Policy, Duke University, Durham, North Carolina 27708, USA.

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http://dx.doi.org/10.1021/pr3007842DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3599776PMC
February 2013

Solid-phase capture for the detection and relative quantification of S-nitrosoproteins by mass spectrometry.

Methods 2013 Aug 11;62(2):130-7. Epub 2012 Oct 11.

Institute for Genome Sciences and Policy, Duke University Medical Center, Durham, NC 27710, United States.

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http://dx.doi.org/10.1016/j.ymeth.2012.10.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3568208PMC
August 2013

The protein expression landscape of the Arabidopsis root.

Proc Natl Acad Sci U S A 2012 May 23;109(18):6811-8. Epub 2012 Mar 23.

Department of Biology, Duke Center for Systems Biology, and Institute for Genome Sciences and Policy, Duke University, Durham, NC 27708, USA.

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http://www.pnas.org/cgi/doi/10.1073/pnas.1202546109
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http://dx.doi.org/10.1073/pnas.1202546109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3344980PMC
May 2012

Proteomic characterization of the cellular response to nitrosative stress mediated by s-nitrosoglutathione reductase inhibition.

J Proteome Res 2012 Apr 19;11(4):2480-91. Epub 2012 Mar 19.

Division of Pulmonary, Allergy and Critical Care Medicine, Small Molecule Synthesis Facility and Institute for Genome Sciences and Policy, Duke University Medical Center, Durham, North Carolina 27710, United States.

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http://dx.doi.org/10.1021/pr201180mDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3327136PMC
April 2012

Automatically detecting problem list omissions of type 2 diabetes cases using electronic medical records.

AMIA Annu Symp Proc 2011 22;2011:1062-9. Epub 2011 Oct 22.

Northwestern University Feinberg School of Medicine, Chicago, IL, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3243294PMC
February 2013

Analysis of oxygen/glucose-deprivation-induced changes in SUMO3 conjugation using SILAC-based quantitative proteomics.

J Proteome Res 2012 Feb 1;11(2):1108-17. Epub 2011 Dec 1.

Department of Anesthesiology, Multidisciplinary Neuroprotection Laboratories, Duke University Medical Center , Durham, North Carolina 28810, United States.

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http://pubs.acs.org/doi/10.1021/pr200834f
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http://dx.doi.org/10.1021/pr200834fDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3628696PMC
February 2012

Quantitative proteomics reveals metabolic and pathogenic properties of Chlamydia trachomatis developmental forms.

Mol Microbiol 2011 Dec 7;82(5):1185-203. Epub 2011 Nov 7.

Department of Molecular Genetics and Microbiology and Center for Microbial Pathogenesis, Duke University Medical Center, Durham, NC, USA.

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http://dx.doi.org/10.1111/j.1365-2958.2011.07877.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3225693PMC
December 2011

Association of calcineurin with the COPI protein Sec28 and the COPII protein Sec13 revealed by quantitative proteomics.

PLoS One 2011 3;6(10):e25280. Epub 2011 Oct 3.

Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, North Carolina, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0025280PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3184950PMC
January 2012