Wilbert Zwart

Wilbert Zwart

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Wilbert Zwart

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Exogenous ERα Expression in the Mammary Epithelium Decreases Over Time and Does Not Contribute to p53-Deficient Mammary Tumor Formation in Mice.

Authors:
Lisette M Cornelissen Linda Henneman Anne Paulien Drenth Eva Schut Roebi de Bruijn Sjoerd Klarenbeek Wilbert Zwart Jos Jonkers

J Mammary Gland Biol Neoplasia 2019 Dec 15;24(4):305-321. Epub 2019 Nov 15.

Division of Molecular Pathology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066CX, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1007/s10911-019-09437-zDOI Listing
December 2019

Cistrome Partitioning Reveals Convergence of Somatic Mutations and Risk Variants on Master Transcription Regulators in Primary Prostate Tumors.

Authors:
Parisa Mazrooei Ken J Kron Yanyun Zhu Stanley Zhou Giacomo Grillo Tahmid Mehdi Musaddeque Ahmed Tesa M Severson Paul Guilhamon Nicholas Sinnott Armstrong Vincent Huang Takafumi N Yamaguchi Michael Fraser Theodorus van der Kwast Paul C Boutros Housheng Hansen He Andries M Bergman Robert G Bristow Wilbert Zwart Mathieu Lupien

Cancer Cell 2019 Dec 14;36(6):674-689.e6. Epub 2019 Nov 14.

Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 1L7, Canada; Department of Medical Biophysics, University of Toronto, Toronto, ON M5G 1L7, Canada; Ontario Institute for Cancer Research, Toronto, ON M5G 0A3, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2019.10.005DOI Listing
December 2019

Androgen modulation of XBP1 is functionally driving part of the AR transcriptional program.

Authors:
Suzan Stelloo Simon Linder Ekaterina Nevedomskaya Eider Valle-Encinas Iris de Rink Lodewyk Wessels Henk van der Poel Andries M Bergman Wilbert Zwart

Endocr Relat Cancer 2019 Dec 1. Epub 2019 Dec 1.

W Zwart, Oncogenomics, NKI, Amsterdam, Netherlands.

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http://dx.doi.org/10.1530/ERC-19-0181DOI Listing
December 2019

Genomic data integration by WON-PARAFAC identifies interpretable factors for predicting drug-sensitivity in vivo.

Authors:
Yongsoo Kim Tycho Bismeijer Wilbert Zwart Lodewyk F A Wessels Daniel J Vis

Nat Commun 2019 Nov 6;10(1):5034. Epub 2019 Nov 6.

Division of Molecular Carcinogenesis, Oncode Institute, The Netherlands Cancer Institute, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1038/s41467-019-13027-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6834616PMC
November 2019

The genomic landscape of metastatic castration-resistant prostate cancers reveals multiple distinct genotypes with potential clinical impact.

Authors:
Lisanne F van Dessel Job van Riet Minke Smits Yanyun Zhu Paul Hamberg Michiel S van der Heijden Andries M Bergman Inge M van Oort Ronald de Wit Emile E Voest Neeltje Steeghs Takafumi N Yamaguchi Julie Livingstone Paul C Boutros John W M Martens Stefan Sleijfer Edwin Cuppen Wilbert Zwart Harmen J G van de Werken Niven Mehra Martijn P Lolkema

Nat Commun 2019 Nov 20;10(1):5251. Epub 2019 Nov 20.

Department of Medical Oncology, Erasmus MC Cancer Institute, Erasmus University Medical Center Rotterdam, Rotterdam, The Netherlands.

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http://dx.doi.org/10.1038/s41467-019-13084-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6868175PMC
November 2019

A CRISPR-Cas9 screen identifies essential CTCF anchor sites for estrogen receptor-driven breast cancer cell proliferation.

Authors:
Gozde Korkmaz Zohar Manber Rui Lopes Stefan Prekovic Karianne Schuurman Yongsoo Kim Hans Teunissen Koen Flach Elzo de Wit Giorgio G Galli Wilbert Zwart Ran Elkon Reuven Agami

Nucleic Acids Res 2019 10;47(18):9557-9572

Division of Oncogenomics, Oncode Institute, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands.

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http://dx.doi.org/10.1093/nar/gkz675DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6765117PMC
October 2019

GATA3 Truncating Mutations Promote Cistromic Re-Programming In Vitro, but Not Mammary Tumor Formation in Mice.

Authors:
Lisette M Cornelissen Roebi de Bruijn Linda Henneman Yongsoo Kim Wilbert Zwart Jos Jonkers

J Mammary Gland Biol Neoplasia 2019 Sep 19;24(3):271-284. Epub 2019 Jun 19.

Division of Molecular Pathology, Oncode Institute, The Netherlands Cancer Institute, Plesmanlaan 121, 1066CX, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1007/s10911-019-09432-4DOI Listing
September 2019

IGF-1R pathway activation as putative biomarker for linsitinib therapy to revert tamoxifen resistance in ER-positive breast cancer.

Authors:
Dinja T Kruger Xanthippi Alexi Mark Opdam Karianne Schuurman Leonie Voorwerk Joyce Sanders Vincent van der Noort Epie Boven Wilbert Zwart Sabine C Linn

Int J Cancer 2019 Sep 6. Epub 2019 Sep 6.

Division of Molecular Pathology, The Netherlands Cancer Institute, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1002/ijc.32668DOI Listing
September 2019

Identification of mineralocorticoid receptor target genes in the mouse hippocampus.

Authors:
Lisa T C M van Weert Jacobus C Buurstede Hetty C M Sips Sabine Vettorazzi Isabel M Mol Jakob Hartmann Stefan Prekovic Wilbert Zwart Mathias V Schmidt Benno Roozendaal Jan P Tuckermann R Angela Sarabdjitsingh Onno C Meijer

J Neuroendocrinol 2019 Aug 14;31(8):e12735. Epub 2019 Jun 14.

Einthoven Laboratory, Division of Endocrinology, Department of Medicine, Leiden University Medical Center, Leiden, The Netherlands.

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https://onlinelibrary.wiley.com/doi/abs/10.1111/jne.12735
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http://dx.doi.org/10.1111/jne.12735DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6771480PMC
August 2019

Loss of p53 triggers WNT-dependent systemic inflammation to drive breast cancer metastasis.

Authors:
Max D Wellenstein Seth B Coffelt Danique E M Duits Martine H van Miltenburg Maarten Slagter Iris de Rink Linda Henneman Sjors M Kas Stefan Prekovic Cheei-Sing Hau Kim Vrijland Anne Paulien Drenth Renske de Korte-Grimmerink Eva Schut Ingrid van der Heijden Wilbert Zwart Lodewyk F A Wessels Ton N Schumacher Jos Jonkers Karin E de Visser

Nature 2019 Aug 31;572(7770):538-542. Epub 2019 Jul 31.

Division of Tumour Biology & Immunology, Oncode Institute, Netherlands Cancer Institute, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1038/s41586-019-1450-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6707815PMC
August 2019

Dissecting the predictive value of MAPK/AKT/estrogen-receptor phosphorylation axis in primary breast cancer to treatment response for tamoxifen over exemestane: a Translational Report of the Intergroup Exemestane Study (IES)-PathIES.

Authors:
Zsolt Szijgyarto Koen D Flach Mark Opdam Carlo Palmieri Sabine C Linn Jelle Wesseling Simak Ali Judith M Bliss Maggie Chon U Cheang Wilbert Zwart R Charles Coombes

Breast Cancer Res Treat 2019 May 24;175(1):149-163. Epub 2019 Jan 24.

Department of Cancer and Surgery, Faculty of Medicine, Imperial College London, Du Cane Road, London, W12 0NN, UK.

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http://dx.doi.org/10.1007/s10549-018-05110-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6491661PMC
May 2019

CHD1 Loss Alters AR Binding at Lineage-Specific Enhancers and Modulates Distinct Transcriptional Programs to Drive Prostate Tumorigenesis.

Authors:
Michael A Augello Deli Liu Lesa D Deonarine Brian D Robinson Dennis Huang Suzan Stelloo Mirjam Blattner Ashley S Doane Elissa W P Wong Yu Chen Mark A Rubin Himisha Beltran Olivier Elemento Andries M Bergman Wilbert Zwart Andrea Sboner Noah Dephoure Christopher E Barbieri

Cancer Cell 2019 May;35(5):817-819

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http://dx.doi.org/10.1016/j.ccell.2019.04.012DOI Listing
May 2019

CHD1 Loss Alters AR Binding at Lineage-Specific Enhancers and Modulates Distinct Transcriptional Programs to Drive Prostate Tumorigenesis.

Authors:
Michael A Augello Deli Liu Lesa D Deonarine Brian D Robinson Dennis Huang Suzan Stelloo Mirjam Blattner Ashley S Doane Elissa W P Wong Yu Chen Mark A Rubin Himisha Beltran Olivier Elemento Andries M Bergman Wilbert Zwart Andrea Sboner Noah Dephoure Christopher E Barbieri

Cancer Cell 2019 Apr 28;35(4):603-617.e8. Epub 2019 Mar 28.

Department of Urology, Weill Cornell Medicine, New York, NY 10065, USA; Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, NY 10065, USA; Caryl and Israel Englander Institute for Precision Medicine, Weill Cornell Medicine, New York, NY 10065, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2019.03.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6467783PMC
April 2019

Androgen receptor enhancer usage and the chromatin regulatory landscape in human prostate cancers.

Authors:
Suzan Stelloo Andries M Bergman Wilbert Zwart

Endocr Relat Cancer 2019 Mar 1. Epub 2019 Mar 1.

W Zwart, Oncogenomics, Antoni van Leeuwenhoek Nederlands Kanker Instituut, Amsterdam, Netherlands.

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http://dx.doi.org/10.1530/ERC-19-0032DOI Listing
March 2019

Optimized ChIP-seq method facilitates transcription factor profiling in human tumors.

Authors:
Abhishek A Singh Karianne Schuurman Ekaterina Nevedomskaya Suzan Stelloo Simon Linder Marjolein Droog Yongsoo Kim Joyce Sanders Henk van der Poel Andries M Bergman Lodewyk Fa Wessels Wilbert Zwart

Life Sci Alliance 2019 02 28;2(1):e201800115. Epub 2018 Dec 28.

Divisions of Oncogenomics, Oncode Institute, Netherlands Cancer Institute, Amsterdam, the Netherlands.

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http://www.life-science-alliance.org/lookup/doi/10.26508/lsa
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http://dx.doi.org/10.26508/lsa.201800115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311467PMC
February 2019

Frequent clonal relations between metastases and non-index prostate cancer lesions.

Authors:
Jeroen Kneppers Oscar Krijgsman Monique Melis Jeroen de Jong Daniel S Peeper Elise Bekers Henk G van der Poel Wilbert Zwart Andries M Bergman

JCI Insight 2019 Jan 24;4(2). Epub 2019 Jan 24.

Division of Oncogenomics, Netherlands Cancer Institute, Amsterdam, Netherlands.

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https://insight.jci.org/articles/view/124756
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http://dx.doi.org/10.1172/jci.insight.124756DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6413780PMC
January 2019

FOXA1 levels are decreased in pleural breast cancer metastases after adjuvant endocrine therapy, and this is associated with poor outcome.

Authors:
Willemijne Schrijver Karianne Schuurman Annelot van Rossum Marjolein Droog Carmen Jeronimo Sofia Salta Rui Henrique Jelle Wesseling Cathy Moelans Sabine C Linn Michel van den Heuvel Paul van Diest Wilbert Zwart

Mol Oncol 2018 11 12;12(11):1884-1894. Epub 2018 Oct 12.

Division of Oncogenomics, Oncode Institute, The Netherlands Cancer Institute, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1002/1878-0261.12353DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6210032PMC
November 2018

CUEDC1 is a primary target of ERα essential for the growth of breast cancer cells.

Authors:
Rui Lopes Gozde Korkmaz Sonia Aristin Revilla Romy van Vliet Remco Nagel Lars Custers Yongsoo Kim Pieter C van Breugel Wilbert Zwart Behzad Moumbeini Zohar Manber Ran Elkon Reuven Agami

Cancer Lett 2018 11 23;436:87-95. Epub 2018 Aug 23.

Division of Oncogenomics, Oncode Institute, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands; Department of Molecular Genetics, Erasmus University Medical Center, Wytemaweg 80, 3015 CN, Rotterdam, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.canlet.2018.08.018DOI Listing
November 2018

Integrative epigenetic taxonomy of primary prostate cancer.

Authors:
Suzan Stelloo Ekaterina Nevedomskaya Yongsoo Kim Karianne Schuurman Eider Valle-Encinas João Lobo Oscar Krijgsman Daniel Simon Peeper Seiwon Laura Chang Felix Yi-Chung Feng Lodewyk Frederik Ary Wessels Rui Henrique Carmen Jerónimo Andries Marinus Bergman Wilbert Zwart

Nat Commun 2018 11 21;9(1):4900. Epub 2018 Nov 21.

Division of Oncogenomics, Oncode Institute, The Netherlands Cancer Institute, Amsterdam, 1066 CX, The Netherlands.

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http://dx.doi.org/10.1038/s41467-018-07270-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6249266PMC
November 2018

Trophoblast Glycoprotein is Associated With a Favorable Outcome for Mesothelioma and a Target for Antibody Drug Conjugates.

Authors:
Laurel M Schunselaar Kim Monkhorst Vincent van der Noort Ruud Wijdeven Dennis Peters Wilbert Zwart Jacques Neefjes Paul Baas

J Thorac Oncol 2018 10 27;13(10):1577-1587. Epub 2018 Jun 27.

Department of Thoracic Oncology, Netherlands Cancer Institute, Amsterdam, The Netherlands. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S15560864183071
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http://dx.doi.org/10.1016/j.jtho.2018.06.008DOI Listing
October 2018

Enzalutamide therapy for advanced prostate cancer: efficacy, resistance and beyond

Authors:
Simon Linder Henk G van der Poel Andries M Bergman Wilbert Zwart Stefan Prekovic

Endocr Relat Cancer 2018 10 31;26(1):R31-R52. Epub 2018 Oct 31.

Division of Oncogenomics, Oncode Institute, The Netherlands Cancer Institute, Amsterdam, The Netherlands.

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https://erc.bioscientifica.com/view/journals/erc/26/1/ERC-18
Publisher Site
http://dx.doi.org/10.1530/ERC-18-0289DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6215909PMC
October 2018

BRCA1-associated mammary tumorigenesis is dependent on estrogen rather than progesterone signaling.

Authors:
Marieke van de Ven Xiaoling Liu Eline van der Burg Sjoerd Klarenbeek Xanthippi Alexi Wilbert Zwart Fred Dijcks Peter Bouwman Jos Jonkers

J Pathol 2018 09 4;246(1):41-53. Epub 2018 Jul 4.

Division of Molecular Pathology, Oncode Institute, The Netherlands Cancer Institute, Amsterdam, The Netherlands.

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http://doi.wiley.com/10.1002/path.5105
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http://dx.doi.org/10.1002/path.5105DOI Listing
September 2018

Loss of androgen receptor signaling in prostate cancer-associated fibroblasts (CAFs) promotes CCL2- and CXCL8-mediated cancer cell migration.

Authors:
Bianca Cioni Ekaterina Nevedomskaya Monique H M Melis Johan van Burgsteden Suzan Stelloo Emma Hodel Daniele Spinozzi Jeroen de Jong Henk van der Poel Jan Paul de Boer Lodewyk F A Wessels Wilbert Zwart Andries M Bergman

Mol Oncol 2018 08 10;12(8):1308-1323. Epub 2018 Jul 10.

Division of Oncogenomics, The Netherlands Cancer Institute (NKI), Amsterdam, The Netherlands.

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http://dx.doi.org/10.1002/1878-0261.12327DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6068356PMC
August 2018

Nuclear Receptor Nur77 Limits the Macrophage Inflammatory Response through Transcriptional Reprogramming of Mitochondrial Metabolism.

Authors:
Duco Steven Koenis Lejla Medzikovic Pieter Bas van Loenen Michel van Weeghel Stephan Huveneers Mariska Vos Ingrid Johanna Evers-van Gogh Jan Van den Bossche Dave Speijer Yongsoo Kim Lodewyk Wessels Noam Zelcer Wilbert Zwart Eric Kalkhoven Carlie Jacoba de Vries

Cell Rep 2018 08;24(8):2127-2140.e7

Amsterdam UMC, University of Amsterdam, Medical Biochemistry, Amsterdam Cardiovascular Sciences, Meibergdreef 9, Amsterdam 1105 AZ, The Netherlands. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S22111247183116
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http://dx.doi.org/10.1016/j.celrep.2018.07.065DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6113932PMC
August 2018

ERα activity depends on interaction and target site corecruitment with phosphorylated CREB1.

Authors:
Melissa Berto Valerie Jean Wilbert Zwart Didier Picard

Life Sci Alliance 2018 Jun 7;1(3):e201800055. Epub 2018 Jun 7.

Département de Biologie Cellulaire and Institute of Genetics and Genomics of Geneva, Université de Genève, Genève, Switzerland.

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http://www.life-science-alliance.org/lookup/doi/10.26508/lsa
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http://dx.doi.org/10.26508/lsa.201800055DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6238530PMC
June 2018

Chemical Profiling of Primary Mesothelioma Cultures Defines Subtypes with Different Expression Profiles and Clinical Responses.

Authors:
Laurel M Schunselaar Josine M M F Quispel-Janssen Yongsoo Kim Constantine Alifrangis Wilbert Zwart Paul Baas Jacques Neefjes

Clin Cancer Res 2018 04 24;24(7):1761-1770. Epub 2017 Oct 24.

Department of Chemical Immunology, Leiden University Medical Center, Leiden, the Netherlands.

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http://dx.doi.org/10.1158/1078-0432.CCR-17-1345DOI Listing
April 2018

Characterizing steroid hormone receptor chromatin binding landscapes in male and female breast cancer.

Authors:
Tesa M Severson Yongsoo Kim Stacey E P Joosten Karianne Schuurman Petra van der Groep Cathy B Moelans Natalie D Ter Hoeve Quirine F Manson John W Martens Carolien H M van Deurzen Ellis Barbe Ingrid Hedenfalk Peter Bult Vincent T H B M Smit Sabine C Linn Paul J van Diest Lodewyk Wessels Wilbert Zwart

Nat Commun 2018 02 2;9(1):482. Epub 2018 Feb 2.

Division of Oncogenomics, Oncode Institute, Netherlands Cancer Institute, 1066 CX, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1038/s41467-018-02856-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5797120PMC
February 2018

Discovery of naturally occurring ESR1 mutations in breast cancer cell lines modelling endocrine resistance.

Authors:
Lesley-Ann Martin Ricardo Ribas Nikiana Simigdala Eugene Schuster Sunil Pancholi Tencho Tenev Pascal Gellert Laki Buluwela Alison Harrod Allan Thornhill Joanna Nikitorowicz-Buniak Amandeep Bhamra Marc-Olivier Turgeon George Poulogiannis Qiong Gao Vera Martins Margaret Hills Isaac Garcia-Murillas Charlotte Fribbens Neill Patani Zheqi Li Matthew J Sikora Nicholas Turner Wilbert Zwart Steffi Oesterreich Jason Carroll Simak Ali Mitch Dowsett

Nat Commun 2017 11 30;8(1):1865. Epub 2017 Nov 30.

Breast Cancer Now Toby Robins Research Centre, Institute of Cancer Research, London, SW7 3RP, UK.

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http://dx.doi.org/10.1038/s41467-017-01864-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5709387PMC
November 2017

Loss of steroid hormone receptors is common in malignant pleural and peritoneal effusions of breast cancer patients treated with endocrine therapy.

Authors:
Willemijne A M E Schrijver Karianne Schuurman Annelot van Rossum Ton Peeters Natalie Ter Hoeve Wilbert Zwart Paul J van Diest Cathy B Moelans

Oncotarget 2017 Aug 20;8(33):55550-55561. Epub 2017 Feb 20.

Department of Pathology, University Medical Center Utrecht, The Netherlands.

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http://dx.doi.org/10.18632/oncotarget.15548DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5589680PMC
August 2017

A review of estrogen receptor/androgen receptor genomics in male breast cancer.

Authors:
Tesa M Severson Wilbert Zwart

Endocr Relat Cancer 2017 03 6;24(3):R27-R34. Epub 2017 Jan 6.

Division of Molecular Pathologythe Netherlands Cancer Institute, Amsterdam, the Netherlands

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http://dx.doi.org/10.1530/ERC-16-0225DOI Listing
March 2017

Estrogen receptor α wields treatment-specific enhancers between morphologically similar endometrial tumors.

Authors:
Marjolein Droog Ekaterina Nevedomskaya Gwen M Dackus Renske Fles Yongsoo Kim Harry Hollema Marian J Mourits Petra M Nederlof Hester H van Boven Sabine C Linn Flora E van Leeuwen Lodewyk F A Wessels Wilbert Zwart

Proc Natl Acad Sci U S A 2017 02 6;114(8):E1316-E1325. Epub 2017 Feb 6.

Department of Molecular Pathology, Netherlands Cancer Institute, 1066 CX Amsterdam, The Netherlands;

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http://dx.doi.org/10.1073/pnas.1615233114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5338442PMC
February 2017

The Estrogen Receptor α-Cistrome Beyond Breast Cancer.

Authors:
Marjolein Droog Mark Mensink Wilbert Zwart

Mol Endocrinol 2016 Oct 4;30(10):1046-1058. Epub 2016 Aug 4.

Division of Molecular Pathology, The Netherlands Cancer Institute, 1066 CX Amsterdam, The Netherlands.

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http://dx.doi.org/10.1210/me.2016-1062DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5414603PMC
October 2016

Comparative Cistromics Reveals Genomic Cross-talk between FOXA1 and ERα in Tamoxifen-Associated Endometrial Carcinomas.

Authors:
Marjolein Droog Ekaterina Nevedomskaya Yongsoo Kim Tesa Severson Koen D Flach Mark Opdam Karianne Schuurman Patrycja Gradowska Michael Hauptmann Gwen Dackus Harry Hollema Marian Mourits Petra Nederlof Hester van Boven Sabine C Linn Lodewyk Wessels Flora E van Leeuwen Wilbert Zwart

Cancer Res 2016 07 6;76(13):3773-84. Epub 2016 May 6.

Department of Molecular Pathology, Netherlands Cancer Institute, Amsterdam, the Netherlands.

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http://dx.doi.org/10.1158/0008-5472.CAN-14-1813DOI Listing
July 2016

The Effects of Enzalutamide Monotherapy on Multiparametric 3T MR Imaging in Prostate Cancer.

Authors:
Rosanne Cv Van der Roest Petra J van Houdt Stijn Wtpj Heijmink Jeroen de Jong André M Bergman Wilbert Zwart Uulke A van der Heide Henk G van der Poel

Urol Case Rep 2016 Jul 26;7:67-9. Epub 2016 May 26.

Department of Urology, The Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands.

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http://dx.doi.org/10.1016/j.eucr.2016.04.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4909636PMC
July 2016

Neoadjuvant tamoxifen synchronizes ERα binding and gene expression profiles related to outcome and proliferation.

Authors:
Tesa M Severson Ekaterina Nevedomskaya Justine Peeters Thomas Kuilman Oscar Krijgsman Annelot van Rossum Marjolein Droog Yongsoo Kim Rutger Koornstra Inès Beumer Annuska M Glas Daniel Peeper Jelle Wesseling Iris M Simon Lodewyk Wessels Sabine C Linn Wilbert Zwart

Oncotarget 2016 Jun;7(23):33901-18

Division of Molecular Pathology, Netherlands Cancer Institute, Amsterdam, CX, The Netherlands.

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http://dx.doi.org/10.18632/oncotarget.8983DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5085127PMC
June 2016

Mastermind-Like 3 Controls Proliferation and Differentiation in Neuroblastoma.

Authors:
Guus J J E Heynen Ekaterina Nevedomskaya Sander Palit Noorjahan Jagalur Basheer Cor Lieftink Andreas Schlicker Wilbert Zwart Rene Bernards Prashanth Kumar Bajpe

Mol Cancer Res 2016 05 19;14(5):411-22. Epub 2016 Jan 19.

Division of Molecular Carcinogenesis, The Netherlands Cancer Institute, Amsterdam, the Netherlands. Cancer Genomics Center Netherlands, The Netherlands Cancer Institute, Amsterdam, the Netherlands.

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http://mcr.aacrjournals.org/content/14/5/411.full-text.pdf
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http://dx.doi.org/10.1158/1541-7786.MCR-15-0291-TDOI Listing
May 2016

The first decade of estrogen receptor cistromics in breast cancer.

Authors:
Koen D Flach Wilbert Zwart

J Endocrinol 2016 05 23;229(2):R43-56. Epub 2016 Feb 23.

Division of Molecular PathologyThe Netherlands Cancer Institute, Amsterdam, The Netherlands

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http://dx.doi.org/10.1530/JOE-16-0003DOI Listing
May 2016

mTOR pathway activation is a favorable prognostic factor in human prostate adenocarcinoma.

Authors:
Suzan Stelloo Joyce Sanders Ekaterina Nevedomskaya Jeroen de Jong Dennis Peters Geert J L H van Leenders Guido Jenster Andries M Bergman Wilbert Zwart

Oncotarget 2016 May;7(22):32916-24

Division of Molecular Pathology, The Netherlands Cancer Institute, Amsterdam, The Netherlands.

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http://dx.doi.org/10.18632/oncotarget.8767DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5078062PMC
May 2016

Androgen receptor DNA binding and chromatin accessibility profiling in prostate cancer.

Authors:
Ekaterina Nevedomskaya Suzan Stelloo Henk G van der Poel Jeroen de Jong Lodewyk F A Wessels Andries M Bergman Wilbert Zwart

Genom Data 2016 Mar 28;7:124-6. Epub 2015 Dec 28.

Division of Molecular Pathology, The Netherlands Cancer Institute, Amsterdam, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands.

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http://dx.doi.org/10.1016/j.gdata.2015.12.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4778643PMC
March 2016

Functional genetic screens for enhancer elements in the human genome using CRISPR-Cas9.

Authors:
Gozde Korkmaz Rui Lopes Alejandro P Ugalde Ekaterina Nevedomskaya Ruiqi Han Ksenia Myacheva Wilbert Zwart Ran Elkon Reuven Agami

Nat Biotechnol 2016 Feb 11;34(2):192-8. Epub 2016 Jan 11.

Division of Biological Stress Response, the Netherlands Cancer Institute, Amsterdam, the Netherlands.

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February 2016

SRC3 Phosphorylation at Serine 543 Is a Positive Independent Prognostic Factor in ER-Positive Breast Cancer.

Authors:
Wilbert Zwart Koen D Flach Bharath Rudraraju Tarek M A Abdel-Fatah Ondrej Gojis Sander Canisius David Moore Ekaterina Nevedomskaya Mark Opdam Marjolein Droog Ingrid Hofland Steve Chan Jacqui Shaw Ian O Ellis R Charles Coombes Jason S Carroll Simak Ali Carlo Palmieri

Clin Cancer Res 2016 Jan 14;22(2):479-91. Epub 2015 Sep 14.

Department of Molecular and Clinical Cancer Medicine, Institute of Translational Medicine, The University of Liverpool, Liverpool, United Kingdom. Liverpool and Merseyside Academic Breast Unit, The Linda McCartney Centre, Royal Liverpool University Hospital, Liverpool, United Kingdom. Academic Department of Medical Oncology, Clatterbridge Cancer Centre NHS Foundation Trust, Wirral, United Kingdom.

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http://dx.doi.org/10.1158/1078-0432.CCR-14-3277DOI Listing
January 2016

Androgen receptor profiling predicts prostate cancer outcome.

Authors:
Suzan Stelloo Ekaterina Nevedomskaya Henk G van der Poel Jeroen de Jong Geert J L H van Leenders Guido Jenster Lodewyk F A Wessels Andries M Bergman Wilbert Zwart

EMBO Mol Med 2015 Nov;7(11):1450-64

Division of Molecular Pathology, The Netherlands Cancer Institute, Amsterdam, The Netherlands

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http://dx.doi.org/10.15252/emmm.201505424DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4644377PMC
November 2015

Cognitive effects of endocrine therapy for breast cancer: keep calm and carry on?

Authors:
Wilbert Zwart Huub Terra Sabine C Linn Sanne B Schagen

Nat Rev Clin Oncol 2015 Oct 21;12(10):597-606. Epub 2015 Jul 21.

Department of Psychosocial Research and Epidemiology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066CX Amsterdam, Netherlands.

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http://dx.doi.org/10.1038/nrclinonc.2015.124DOI Listing
October 2015

APOBEC3B-Mediated Cytidine Deamination Is Required for Estrogen Receptor Action in Breast Cancer.

Authors:
Manikandan Periyasamy Hetal Patel Chun-Fui Lai Van T M Nguyen Ekaterina Nevedomskaya Alison Harrod Roslin Russell Judit Remenyi Anna Maria Ochocka Ross S Thomas Frances Fuller-Pace Balázs Győrffy Carlos Caldas Naveenan Navaratnam Jason S Carroll Wilbert Zwart R Charles Coombes Luca Magnani Laki Buluwela Simak Ali

Cell Rep 2015 Oct 24;13(1):108-121. Epub 2015 Sep 24.

Department of Surgery and Cancer, Imperial College London, Hammersmith Hospital Campus, Du Cane Road, London W12 0NN, UK. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2015.08.066DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4597099PMC
October 2015

Effects of Pharmacogenetics on the Pharmacokinetics and Pharmacodynamics of Tamoxifen.

Authors:
Aurelia H M de Vries Schultink Wilbert Zwart Sabine C Linn Jos H Beijnen Alwin D R Huitema

Clin Pharmacokinet 2015 Aug;54(8):797-810

Department of Pharmacy and Pharmacology, Antoni van Leeuwenhoek-The Netherlands Cancer Institute, Louwesweg 6, 1066 EC, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1007/s40262-015-0273-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4513218PMC
August 2015

Protein Kinase A-induced tamoxifen resistance is mediated by anchoring protein AKAP13.

Authors:
Cristiane Bentin Toaldo Xanthippi Alexi Karin Beelen Marleen Kok Michael Hauptmann Maurice Jansen Els Berns Jacques Neefjes Sabine Linn Rob Michalides Wilbert Zwart

BMC Cancer 2015 Aug 14;15:588. Epub 2015 Aug 14.

Division of Molecular Pathology, the Netherlands Cancer Institute, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1186/s12885-015-1591-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4536754PMC
August 2015

Genome-wide epigenetic profiling of breast cancer tumors treated with aromatase inhibitors.

Authors:
Ekaterina Nevedomskaya Lodewyk Wessels Wilbert Zwart

Genom Data 2014 Dec 8;2:195-8. Epub 2014 Jul 8.

Division of Molecular Pathology, Netherlands Cancer Institute, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1016/j.gdata.2014.06.023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4536071PMC
December 2014

Complex formation and function of estrogen receptor α in transcription requires RIP140.

Authors:
Meritxell Rosell Ekaterina Nevedomskaya Suzan Stelloo Jaya Nautiyal Ariel Poliandri Jennifer H Steel Lodewyk F A Wessels Jason S Carroll Malcolm G Parker Wilbert Zwart

Cancer Res 2014 Oct 21;74(19):5469-79. Epub 2014 Aug 21.

Division of Molecular Pathology, the Netherlands Cancer Institute, Amsterdam, the Netherlands.

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http://dx.doi.org/10.1158/0008-5472.CAN-13-3429DOI Listing
October 2014

Phosphorylation of activating transcription factor-2 (ATF-2) within the activation domain is a key determinant of sensitivity to tamoxifen in breast cancer.

Authors:
Bharath Rudraraju Marjolein Droog Tarek M A Abdel-Fatah Wilbert Zwart Athina Giannoudis Mohammed I Malki David Moore Hetal Patel Jacqui Shaw Ian O Ellis Steve Chan Greg N Brooke Ekaterina Nevedomskaya Christiana Lo Nigro Jason Carroll R Charles Coombes Charlotte Bevan Simak Ali Carlo Palmieri

Breast Cancer Res Treat 2014 Sep 22;147(2):295-309. Epub 2014 Aug 22.

Department of Molecular and Clinical Cancer Medicine, Institute of Translational Medicine, University of Liverpool, The Duncan Building, Daulby Street, Liverpool, L69 3GA, UK.

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http://dx.doi.org/10.1007/s10549-014-3098-0DOI Listing
September 2014

USP9X downregulation renders breast cancer cells resistant to tamoxifen.

Authors:
Hendrika M Oosterkamp E Marielle Hijmans Thijn R Brummelkamp Sander Canisius Lodewyk F A Wessels Wilbert Zwart René Bernards

Cancer Res 2014 Jul;74(14):3810-20

Authors' Affiliations: Division of Molecular Carcinogenesis and Cancer Genomics Center Netherlands; and

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http://dx.doi.org/10.1158/0008-5472.CAN-13-1960DOI Listing
July 2014

VAV3 mediates resistance to breast cancer endocrine therapy.

Authors:
Helena Aguilar Ander Urruticoechea Pasi Halonen Kazuma Kiyotani Taisei Mushiroda Xavier Barril Jordi Serra-Musach Abul Islam Livia Caizzi Luciano Di Croce Ekaterina Nevedomskaya Wilbert Zwart Josefine Bostner Elin Karlsson Gizeh Pérez Tenorio Tommy Fornander Dennis C Sgroi Rafael Garcia-Mata Maurice P H M Jansen Nadia García Núria Bonifaci Fina Climent María Teresa Soler Alejo Rodríguez-Vida Miguel Gil Joan Brunet Griselda Martrat Laia Gómez-Baldó Ana I Extremera Agnes Figueras Josep Balart Robert Clarke Kerry L Burnstein Kathryn E Carlson John A Katzenellenbogen Miguel Vizoso Manel Esteller Alberto Villanueva Ana B Rodríguez-Peña Xosé R Bustelo Yusuke Nakamura Hitoshi Zembutsu Olle Stål Roderick L Beijersbergen Miguel Angel Pujana

Breast Cancer Res 2014 May 28;16(3):R53. Epub 2014 May 28.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4076632PMC
May 2014

Drug-induced histone eviction from open chromatin contributes to the chemotherapeutic effects of doxorubicin.

Authors:
Baoxu Pang Xiaohang Qiao Lennert Janssen Arno Velds Tom Groothuis Ron Kerkhoven Marja Nieuwland Huib Ovaa Sven Rottenberg Olaf van Tellingen Jeroen Janssen Peter Huijgens Wilbert Zwart Jacques Neefjes

Nat Commun 2013 ;4:1908

Division of Cell Biology, The Netherlands Cancer Institute, Plesmanlaan 121, Amsterdam 1066CX, The Netherlands.

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http://dx.doi.org/10.1038/ncomms2921DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3674280PMC
December 2013

Co-regulated gene expression by oestrogen receptor α and liver receptor homolog-1 is a feature of the oestrogen response in breast cancer cells.

Authors:
Chun-Fui Lai Koen D Flach Xanthippi Alexi Stephen P Fox Silvia Ottaviani Paul T R Thiruchelvam Fiona J Kyle Ross S Thomas Rosalind Launchbury Hui Hua Holly B Callaghan Jason S Carroll R Charles Coombes Wilbert Zwart Laki Buluwela Simak Ali

Nucleic Acids Res 2013 Dec 17;41(22):10228-40. Epub 2013 Sep 17.

Department of Surgery and Cancer, Imperial College London, London W12 0NN, UK, Department of Molecular Pathology, The Netherlands Cancer Institute, 1066 CX Amsterdam, Netherlands and Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Cambridge CB2 0RE, UK.

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http://dx.doi.org/10.1093/nar/gkt827DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3905875PMC
December 2013

Hallmarks of aromatase inhibitor drug resistance revealed by epigenetic profiling in breast cancer.

Authors:
Maurice P H M Jansen Theo Knijnenburg Esther A Reijm Iris Simon Ron Kerkhoven Marjolein Droog Arno Velds Steven van Laere Luc Dirix Xanthippi Alexi John A Foekens Lodewyk Wessels Sabine C Linn Els M J J Berns Wilbert Zwart

Cancer Res 2013 Nov;73(22):6632-41

Authors' Affiliations: Department of Medical Oncology, Erasmus University Medical Center, Cancer Institute, Rotterdam; Departments of Molecular Carcinogenesis and Molecular Pathology, Central Genomic Facility, the Netherlands Cancer Institute; Agendia NV, Amsterdam, the Netherlands; and Translational Cancer Research Unit, Laboratory of Pathology, Antwerp University/Oncology Centre, GZA Hospitals St-Augustinus, Antwerp, Belgium.

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http://dx.doi.org/10.1158/0008-5472.CAN-13-0704DOI Listing
November 2013

Tamoxifen resistance: from bench to bedside.

Authors:
Marjolein Droog Karin Beelen Sabine Linn Wilbert Zwart

Eur J Pharmacol 2013 Oct 29;717(1-3):47-57. Epub 2013 Mar 29.

Department of Molecular Pathology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands.

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http://dx.doi.org/10.1016/j.ejphar.2012.11.071DOI Listing
October 2013

Estrogen receptor splice variants as a potential source of false-positive estrogen receptor status in breast cancer diagnostics.

Authors:
Floris H Groenendijk Wilbert Zwart Arno Floore Stephanie Akbari Rene Bernards

Breast Cancer Res Treat 2013 Aug 4;140(3):475-84. Epub 2013 Aug 4.

Division of Molecular Carcinogenesis, Cancer Genomics Centre, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1007/s10549-013-2648-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3742961PMC
August 2013

Interaction of 14-3-3 proteins with the estrogen receptor alpha F domain provides a drug target interface.

Authors:
Ingrid J De Vries-van Leeuwen Daniel da Costa Pereira Koen D Flach Sander R Piersma Christian Haase David Bier Zeliha Yalcin Rob Michalides K Anton Feenstra Connie R Jiménez Tom F A de Greef Luc Brunsveld Christian Ottmann Wilbert Zwart Albertus H de Boer

Proc Natl Acad Sci U S A 2013 May 15;110(22):8894-9. Epub 2013 May 15.

Department of Structural Biology, Faculty Earth and Life Sciences, Vrije Universiteit, 1081 HV Amsterdam, The Netherlands.

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http://dx.doi.org/10.1073/pnas.1220809110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3670367PMC
May 2013

A carrier-assisted ChIP-seq method for estrogen receptor-chromatin interactions from breast cancer core needle biopsy samples.

Authors:
Wilbert Zwart Rutger Koornstra Jelle Wesseling Emiel Rutgers Sabine Linn Jason S Carroll

BMC Genomics 2013 Apr 8;14:232. Epub 2013 Apr 8.

Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge, UK.

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http://dx.doi.org/10.1186/1471-2164-14-232DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3637562PMC
April 2013

The transcriptional co-factor RIP140 regulates mammary gland development by promoting the generation of key mitogenic signals.

Authors:
Jaya Nautiyal Jennifer H Steel Meritxell Rosell Mane Olayiwola Oduwole Ariel Poliandri Xanthippi Alexi Nicholas Wood Matti Poutanen Wilbert Zwart John Stingl Malcolm G Parker

Development 2013 Mar;140(5):1079-89

Institute of Reproductive and Developmental Biology, Faculty of Medicine, Imperial College London, Du Cane Road, London W12 0NN, UK.

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http://dx.doi.org/10.1242/dev.085720DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3583043PMC
March 2013

Identification of a pharmacologically tractable Fra-1/ADORA2B axis promoting breast cancer metastasis.

Authors:
Christophe J Desmet Tristan Gallenne Alexandre Prieur Fabien Reyal Nils L Visser Ben S Wittner Marjon A Smit Thomas R Geiger Jamila Laoukili Sedef Iskit Boris Rodenko Wilbert Zwart Bastiaan Evers Hugo Horlings Abderrahrim Ajouaou John Zevenhoven Martin van Vliet Sridhar Ramaswamy Lodewyk F A Wessels Daniel S Peeper

Proc Natl Acad Sci U S A 2013 Mar 12;110(13):5139-44. Epub 2013 Mar 12.

Department of Molecular Oncology, The Netherlands Cancer Institute, 1066 CX, Amsterdam, The Netherlands.

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http://www.pnas.org/cgi/doi/10.1073/pnas.1222085110
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3612632PMC
March 2013

Endogenous purification reveals GREB1 as a key estrogen receptor regulatory factor.

Authors:
Hisham Mohammed Clive D'Santos Aurelien A Serandour H Raza Ali Gordon D Brown Alan Atkins Oscar M Rueda Kelly A Holmes Vasiliki Theodorou Jessica L L Robinson Wilbert Zwart Amel Saadi Caryn S Ross-Innes Suet-Feung Chin Suraj Menon John Stingl Carlo Palmieri Carlos Caldas Jason S Carroll

Cell Rep 2013 Feb 9;3(2):342-9. Epub 2013 Feb 9.

Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK.

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http://dx.doi.org/10.1016/j.celrep.2013.01.010DOI Listing
February 2013

ChIPing away at breast cancer.

Authors:
Luca Magnani Jason Carroll Wilbert Zwart Carlo Palmieri

Lancet Oncol 2012 Dec;13(12):1185-7

Ontario Cancer Institute, University Health Network, MARS/TMDT 8-708, Toronto, ON, M5G 1L7, Canada.

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http://dx.doi.org/10.1016/S1470-2045(12)70511-9DOI Listing
December 2012

Can predictive biomarkers in breast cancer guide adjuvant endocrine therapy?

Authors:
Karin Beelen Wilbert Zwart Sabine C Linn

Nat Rev Clin Oncol 2012 Sep 24;9(9):529-41. Epub 2012 Jul 24.

Department of Molecular Pathology, Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands.

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http://dx.doi.org/10.1038/nrclinonc.2012.121DOI Listing
September 2012

TRPM7 is required for breast tumor cell metastasis.

Authors:
Jeroen Middelbeek Arthur J Kuipers Linda Henneman Daan Visser Ilse Eidhof Remco van Horssen Bé Wieringa Sander V Canisius Wilbert Zwart Lodewyk F Wessels Fred C G J Sweep Peter Bult Paul N Span Frank N van Leeuwen Kees Jalink

Cancer Res 2012 Aug 7;72(16):4250-61. Epub 2012 Aug 7.

Laboratory of Pediatric Oncology, Department of Cell Biology, Nijmegen Centre for Molecular Life Sciences, Radboud University Medical Centre, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1158/0008-5472.CAN-11-3863DOI Listing
August 2012

A diagnostic gene profile for molecular subtyping of breast cancer associated with treatment response.

Authors:
Oscar Krijgsman Paul Roepman Wilbert Zwart Jason S Carroll Sun Tian Femke A de Snoo Richard A Bender Rene Bernards Annuska M Glas

Breast Cancer Res Treat 2012 May 4;133(1):37-47. Epub 2011 Aug 4.

Research and Development, Agendia BV, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1007/s10549-011-1683-zDOI Listing
May 2012

Oestrogen receptor-co-factor-chromatin specificity in the transcriptional regulation of breast cancer.

Authors:
Wilbert Zwart Vasiliki Theodorou Marleen Kok Sander Canisius Sabine Linn Jason S Carroll

EMBO J 2011 Oct 14;30(23):4764-76. Epub 2011 Oct 14.

The Netherlands Cancer Institute, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1038/emboj.2011.368DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3243612PMC
October 2011

Estrogen receptor-positive breast cancer: a multidisciplinary challenge.

Authors:
Wilbert Zwart Vasiliki Theodorou Jason S Carroll

Wiley Interdiscip Rev Syst Biol Med 2011 Mar-Apr;3(2):216-30

Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Cambridge, UK.

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http://dx.doi.org/10.1002/wsbm.109DOI Listing
June 2011

PKA-induced phosphorylation of ERα at serine 305 and high PAK1 levels is associated with sensitivity to tamoxifen in ER-positive breast cancer.

Authors:
Marleen Kok Wilbert Zwart Caroline Holm Renske Fles Michael Hauptmann Laura J Van't Veer Lodewyk F A Wessels Jacques Neefjes Olle Stål Sabine C Linn Göran Landberg Rob Michalides

Breast Cancer Res Treat 2011 Jan 9;125(1):1-12. Epub 2010 Mar 9.

Department of Experimental Therapy, Netherlands Cancer Institute, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1007/s10549-010-0798-yDOI Listing
January 2011

The invariant chain transports TNF family member CD70 to MHC class II compartments in dendritic cells.

Authors:
Wilbert Zwart Victor Peperzak Evert de Vries Anna M Keller Gerda van der Horst Elise A M Veraar Ulf Geumann Hans Janssen Lennert Janssen Shalin H Naik Jacques Neefjes Jannie Borst

J Cell Sci 2010 Nov;123(Pt 21):3817-27

Division of Cell Biology, The Netherlands Cancer Institute, 1066 CX Amsterdam, The Netherlands.

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http://jcs.biologists.org/cgi/doi/10.1242/jcs.068510
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November 2010

A Pumilio-induced RNA structure switch in p27-3' UTR controls miR-221 and miR-222 accessibility.

Authors:
Martijn Kedde Marieke van Kouwenhove Wilbert Zwart Joachim A F Oude Vrielink Ran Elkon Reuven Agami

Nat Cell Biol 2010 Oct 5;12(10):1014-20. Epub 2010 Sep 5.

Division of Gene Regulation, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1038/ncb2105DOI Listing
October 2010

The hinge region of the human estrogen receptor determines functional synergy between AF-1 and AF-2 in the quantitative response to estradiol and tamoxifen.

Authors:
Wilbert Zwart Renée de Leeuw Mariska Rondaij Jacques Neefjes Michael A Mancini Rob Michalides

J Cell Sci 2010 Apr 23;123(Pt 8):1253-61. Epub 2010 Mar 23.

Department of Cell Biology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066CX Amsterdam, The Netherlands.

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http://dx.doi.org/10.1242/jcs.061135DOI Listing
April 2010

Resistance to antiestrogen arzoxifene is mediated by overexpression of cyclin D1.

Authors:
Wilbert Zwart Mariska Rondaij Kees Jalink Z Dave Sharp Michael A Mancini Jacques Neefjes Rob Michalides

Mol Endocrinol 2009 Sep 28;23(9):1335-45. Epub 2009 May 28.

Department of Cell Biology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands.

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http://dx.doi.org/10.1210/me.2008-0268DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2737554PMC
September 2009

Perturbation of estrogen receptor alpha localization with synthetic nona-arginine LXXLL-peptide coactivator binding inhibitors.

Authors:
Maëlle Carraz Wilbert Zwart Trang Phan Rob Michalides Luc Brunsveld

Chem Biol 2009 Jul;16(7):702-11

Chemical Genomics Centre of the Max Planck Society, 44227 Dortmund, Germany; Laboratory of Chemical Biology, Department of Biomedical Engineering, Eindhoven University of Technology, 5600MB Eindhoven, The Netherlands.

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July 2009

Cholesterol sensor ORP1L contacts the ER protein VAP to control Rab7-RILP-p150 Glued and late endosome positioning.

Authors:
Nuno Rocha Coenraad Kuijl Rik van der Kant Lennert Janssen Diane Houben Hans Janssen Wilbert Zwart Jacques Neefjes

J Cell Biol 2009 Jun;185(7):1209-25

Division of Cell Biology, The Netherlands Cancer Institute, 1066CX Amsterdam, Netherlands.

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http://dx.doi.org/10.1083/jcb.200811005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2712958PMC
June 2009

PKA-induced resistance to tamoxifen is associated with an altered orientation of ERalpha towards co-activator SRC-1.

Authors:
Wilbert Zwart Alexander Griekspoor Valeria Berno Kim Lakeman Kees Jalink Michael Mancini Jacques Neefjes Rob Michalides

EMBO J 2007 Aug 12;26(15):3534-44. Epub 2007 Jul 12.

Department of Tumor Biology, The Netherlands Cancer Institute, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1038/sj.emboj.7601791DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1949008PMC
August 2007

Classification of anti-estrogens according to intramolecular FRET effects on phospho-mutants of estrogen receptor alpha.

Authors:
Wilbert Zwart Alexander Griekspoor Mariska Rondaij Desiree Verwoerd Jacques Neefjes Rob Michalides

Mol Cancer Ther 2007 May;6(5):1526-33

Division of Tumor Biology, the Netherlands Cancer Institute, Plesmanlaan 121, 1066CX Amsterdam, the Netherlands.

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http://dx.doi.org/10.1158/1535-7163.MCT-06-0750DOI Listing
May 2007

Visualizing the action of steroid hormone receptors in living cells.

Authors:
Alexander Griekspoor Wilbert Zwart Jacques Neefjes Rob Michalides

Nucl Recept Signal 2007 Mar 9;5:e003. Epub 2007 Mar 9.

Division of Tumor Biology, The Netherlands Cancer Institute, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1621/nrs.05003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1853070PMC
March 2007

Activation of endosomal dynein motors by stepwise assembly of Rab7-RILP-p150Glued, ORP1L, and the receptor betalll spectrin.

Authors:
Marie Johansson Nuno Rocha Wilbert Zwart Ingrid Jordens Lennert Janssen Coenraad Kuijl Vesa M Olkkonen Jacques Neefjes

J Cell Biol 2007 Feb 5;176(4):459-71. Epub 2007 Feb 5.

Department of Molecular Medicine, National Public Health Institute, Biomedicum, FI-00251 Helsinki, Finland.

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http://www.jcb.org/lookup/doi/10.1083/jcb.200606077
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http://dx.doi.org/10.1083/jcb.200606077DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2063981PMC
February 2007

Presenting antigen presentation in living cells using biophysical techniques.

Authors:
Alexander Griekspoor Wilbert Zwart Jacques Neefjes

Curr Opin Microbiol 2005 Jun;8(3):338-43

Division of Tumor Biology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands.

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http://dx.doi.org/10.1016/j.mib.2005.04.007DOI Listing
June 2005

Spatial separation of HLA-DM/HLA-DR interactions within MIIC and phagosome-induced immune escape.

Authors:
Wilbert Zwart Alexander Griekspoor Coenraad Kuijl Marije Marsman Jacco van Rheenen Hans Janssen Jero Calafat Marieke van Ham Lennert Janssen Marcel van Lith Kees Jalink Jacques Neefjes

Immunity 2005 Feb;22(2):221-33

Division of Tumor Biology , Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands.

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http://dx.doi.org/10.1016/j.immuni.2005.01.006DOI Listing
February 2005

Phosphatidylinositol 4-kinasebeta is critical for functional association of rab11 with the Golgi complex.

Authors:
Petra de Graaf Wilbert T Zwart Remco A J van Dijken Magdalena Deneka Thomas K F Schulz Niels Geijsen Paul J Coffer Bart M Gadella Arie J Verkleij Peter van der Sluijs Paul M P van Bergen en Henegouwen

Mol Biol Cell 2004 Apr 6;15(4):2038-47. Epub 2004 Feb 6.

Department of Molecular Cell Biology and Institute of Biomembranes, Utrecht University, The Netherlands.

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http://dx.doi.org/10.1091/mbc.e03-12-0862DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC379297PMC
April 2004