Publications by authors named "Wilbert Zwart"

95Publications

Estrogen Receptor on the move: Cistromic plasticity and its implications in breast cancer.

Mol Aspects Med 2020 Dec 24:100939. Epub 2020 Dec 24.

Laboratory of Chemical Biology and Institute for Complex Molecular Systems, Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, The Netherlands. Electronic address:

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December 2020

Genomic and phenotypic heterogeneity in prostate cancer.

Nat Rev Urol 2020 Dec 16. Epub 2020 Dec 16.

Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

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December 2020

Androgen modulation of XBP1 is functionally driving part of the AR transcriptional program.

Endocr Relat Cancer 2020 Feb;27(2):67-79

Division of Oncogenomics, Oncode Institute, The Netherlands Cancer Institute, Amsterdam, The Netherlands.

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February 2020

Cistrome Partitioning Reveals Convergence of Somatic Mutations and Risk Variants on Master Transcription Regulators in Primary Prostate Tumors.

Cancer Cell 2019 12 14;36(6):674-689.e6. Epub 2019 Nov 14.

Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 1L7, Canada; Department of Medical Biophysics, University of Toronto, Toronto, ON M5G 1L7, Canada; Ontario Institute for Cancer Research, Toronto, ON M5G 0A3, Canada. Electronic address:

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December 2019

Exogenous ERα Expression in the Mammary Epithelium Decreases Over Time and Does Not Contribute to p53-Deficient Mammary Tumor Formation in Mice.

J Mammary Gland Biol Neoplasia 2019 12 15;24(4):305-321. Epub 2019 Nov 15.

Division of Molecular Pathology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066CX, Amsterdam, The Netherlands.

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December 2019

Genomic data integration by WON-PARAFAC identifies interpretable factors for predicting drug-sensitivity in vivo.

Nat Commun 2019 11 6;10(1):5034. Epub 2019 Nov 6.

Division of Molecular Carcinogenesis, Oncode Institute, The Netherlands Cancer Institute, Amsterdam, The Netherlands.

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November 2019

GATA3 Truncating Mutations Promote Cistromic Re-Programming In Vitro, but Not Mammary Tumor Formation in Mice.

J Mammary Gland Biol Neoplasia 2019 09 19;24(3):271-284. Epub 2019 Jun 19.

Division of Molecular Pathology, Oncode Institute, The Netherlands Cancer Institute, Plesmanlaan 121, 1066CX, Amsterdam, The Netherlands.

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September 2019

Identification of mineralocorticoid receptor target genes in the mouse hippocampus.

J Neuroendocrinol 2019 08 14;31(8):e12735. Epub 2019 Jun 14.

Einthoven Laboratory, Division of Endocrinology, Department of Medicine, Leiden University Medical Center, Leiden, The Netherlands.

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August 2019

CHD1 Loss Alters AR Binding at Lineage-Specific Enhancers and Modulates Distinct Transcriptional Programs to Drive Prostate Tumorigenesis.

Cancer Cell 2019 04 28;35(4):603-617.e8. Epub 2019 Mar 28.

Department of Urology, Weill Cornell Medicine, New York, NY 10065, USA; Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, NY 10065, USA; Caryl and Israel Englander Institute for Precision Medicine, Weill Cornell Medicine, New York, NY 10065, USA. Electronic address:

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April 2019

Androgen receptor enhancer usage and the chromatin regulatory landscape in human prostate cancers.

Endocr Relat Cancer 2019 05;26(5):R267-R285

Division of Oncogenomics, Oncode Institute, The Netherlands Cancer Institute, Amsterdam, The Netherlands.

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May 2019

ERα activity depends on interaction and target site corecruitment with phosphorylated CREB1.

Life Sci Alliance 2018 Jun 7;1(3):e201800055. Epub 2018 Jun 7.

Département de Biologie Cellulaire and Institute of Genetics and Genomics of Geneva, Université de Genève, Genève, Switzerland.

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June 2018

Enzalutamide therapy for advanced prostate cancer: efficacy, resistance and beyond

Endocr Relat Cancer 2018 10 31;26(1):R31-R52. Epub 2018 Oct 31.

Division of Oncogenomics, Oncode Institute, The Netherlands Cancer Institute, Amsterdam, The Netherlands.

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October 2018

CUEDC1 is a primary target of ERα essential for the growth of breast cancer cells.

Cancer Lett 2018 11 23;436:87-95. Epub 2018 Aug 23.

Division of Oncogenomics, Oncode Institute, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands; Department of Molecular Genetics, Erasmus University Medical Center, Wytemaweg 80, 3015 CN, Rotterdam, The Netherlands. Electronic address:

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November 2018

Trophoblast Glycoprotein is Associated With a Favorable Outcome for Mesothelioma and a Target for Antibody Drug Conjugates.

J Thorac Oncol 2018 10 27;13(10):1577-1587. Epub 2018 Jun 27.

Department of Thoracic Oncology, Netherlands Cancer Institute, Amsterdam, The Netherlands. Electronic address:

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October 2018

BRCA1-associated mammary tumorigenesis is dependent on estrogen rather than progesterone signaling.

J Pathol 2018 09 4;246(1):41-53. Epub 2018 Jul 4.

Division of Molecular Pathology, Oncode Institute, The Netherlands Cancer Institute, Amsterdam, The Netherlands.

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September 2018

A review of estrogen receptor/androgen receptor genomics in male breast cancer.

Endocr Relat Cancer 2017 03 6;24(3):R27-R34. Epub 2017 Jan 6.

Division of Molecular Pathologythe Netherlands Cancer Institute, Amsterdam, the Netherlands

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March 2017

The Estrogen Receptor α-Cistrome Beyond Breast Cancer.

Mol Endocrinol 2016 Oct 4;30(10):1046-1058. Epub 2016 Aug 4.

Division of Molecular Pathology, The Netherlands Cancer Institute, 1066 CX Amsterdam, The Netherlands.

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October 2016

The Effects of Enzalutamide Monotherapy on Multiparametric 3T MR Imaging in Prostate Cancer.

Urol Case Rep 2016 Jul 26;7:67-9. Epub 2016 May 26.

Department of Urology, The Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands.

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July 2016

Androgen receptor DNA binding and chromatin accessibility profiling in prostate cancer.

Genom Data 2016 Mar 28;7:124-6. Epub 2015 Dec 28.

Division of Molecular Pathology, The Netherlands Cancer Institute, Amsterdam, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands.

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March 2016

The first decade of estrogen receptor cistromics in breast cancer.

J Endocrinol 2016 05 23;229(2):R43-56. Epub 2016 Feb 23.

Division of Molecular PathologyThe Netherlands Cancer Institute, Amsterdam, The Netherlands

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May 2016

Mastermind-Like 3 Controls Proliferation and Differentiation in Neuroblastoma.

Mol Cancer Res 2016 05 19;14(5):411-22. Epub 2016 Jan 19.

Division of Molecular Carcinogenesis, The Netherlands Cancer Institute, Amsterdam, the Netherlands. Cancer Genomics Center Netherlands, The Netherlands Cancer Institute, Amsterdam, the Netherlands.

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May 2016

Functional genetic screens for enhancer elements in the human genome using CRISPR-Cas9.

Nat Biotechnol 2016 Feb 11;34(2):192-8. Epub 2016 Jan 11.

Division of Biological Stress Response, the Netherlands Cancer Institute, Amsterdam, the Netherlands.

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February 2016

Genome-wide epigenetic profiling of breast cancer tumors treated with aromatase inhibitors.

Genom Data 2014 Dec 8;2:195-8. Epub 2014 Jul 8.

Division of Molecular Pathology, Netherlands Cancer Institute, Amsterdam, The Netherlands.

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December 2014

SRC3 Phosphorylation at Serine 543 Is a Positive Independent Prognostic Factor in ER-Positive Breast Cancer.

Clin Cancer Res 2016 Jan 14;22(2):479-91. Epub 2015 Sep 14.

Department of Molecular and Clinical Cancer Medicine, Institute of Translational Medicine, The University of Liverpool, Liverpool, United Kingdom. Liverpool and Merseyside Academic Breast Unit, The Linda McCartney Centre, Royal Liverpool University Hospital, Liverpool, United Kingdom. Academic Department of Medical Oncology, Clatterbridge Cancer Centre NHS Foundation Trust, Wirral, United Kingdom.

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January 2016

Cognitive effects of endocrine therapy for breast cancer: keep calm and carry on?

Nat Rev Clin Oncol 2015 Oct 21;12(10):597-606. Epub 2015 Jul 21.

Department of Psychosocial Research and Epidemiology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066CX Amsterdam, Netherlands.

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October 2015

Effects of Pharmacogenetics on the Pharmacokinetics and Pharmacodynamics of Tamoxifen.

Clin Pharmacokinet 2015 Aug;54(8):797-810

Department of Pharmacy and Pharmacology, Antoni van Leeuwenhoek-The Netherlands Cancer Institute, Louwesweg 6, 1066 EC, Amsterdam, The Netherlands.

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August 2015

USP9X downregulation renders breast cancer cells resistant to tamoxifen.

Cancer Res 2014 Jul;74(14):3810-20

Authors' Affiliations: Division of Molecular Carcinogenesis and Cancer Genomics Center Netherlands; and

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July 2014

Hallmarks of aromatase inhibitor drug resistance revealed by epigenetic profiling in breast cancer.

Cancer Res 2013 Nov;73(22):6632-41

Authors' Affiliations: Department of Medical Oncology, Erasmus University Medical Center, Cancer Institute, Rotterdam; Departments of Molecular Carcinogenesis and Molecular Pathology, Central Genomic Facility, the Netherlands Cancer Institute; Agendia NV, Amsterdam, the Netherlands; and Translational Cancer Research Unit, Laboratory of Pathology, Antwerp University/Oncology Centre, GZA Hospitals St-Augustinus, Antwerp, Belgium.

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November 2013

Co-regulated gene expression by oestrogen receptor α and liver receptor homolog-1 is a feature of the oestrogen response in breast cancer cells.

Nucleic Acids Res 2013 Dec 17;41(22):10228-40. Epub 2013 Sep 17.

Department of Surgery and Cancer, Imperial College London, London W12 0NN, UK, Department of Molecular Pathology, The Netherlands Cancer Institute, 1066 CX Amsterdam, Netherlands and Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Cambridge CB2 0RE, UK.

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December 2013

Estrogen receptor splice variants as a potential source of false-positive estrogen receptor status in breast cancer diagnostics.

Breast Cancer Res Treat 2013 Aug 4;140(3):475-84. Epub 2013 Aug 4.

Division of Molecular Carcinogenesis, Cancer Genomics Centre, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands.

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August 2013

A carrier-assisted ChIP-seq method for estrogen receptor-chromatin interactions from breast cancer core needle biopsy samples.

BMC Genomics 2013 Apr 8;14:232. Epub 2013 Apr 8.

Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge, UK.

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April 2013

Tamoxifen resistance: from bench to bedside.

Eur J Pharmacol 2013 Oct 29;717(1-3):47-57. Epub 2013 Mar 29.

Department of Molecular Pathology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands.

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October 2013

ChIPing away at breast cancer.

Lancet Oncol 2012 Dec;13(12):1185-7

Ontario Cancer Institute, University Health Network, MARS/TMDT 8-708, Toronto, ON, M5G 1L7, Canada.

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December 2012

TRPM7 is required for breast tumor cell metastasis.

Cancer Res 2012 Aug 7;72(16):4250-61. Epub 2012 Aug 7.

Laboratory of Pediatric Oncology, Department of Cell Biology, Nijmegen Centre for Molecular Life Sciences, Radboud University Medical Centre, Nijmegen, The Netherlands.

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August 2012

Can predictive biomarkers in breast cancer guide adjuvant endocrine therapy?

Nat Rev Clin Oncol 2012 Sep 24;9(9):529-41. Epub 2012 Jul 24.

Department of Molecular Pathology, Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands.

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September 2012

Estrogen receptor-positive breast cancer: a multidisciplinary challenge.

Wiley Interdiscip Rev Syst Biol Med 2011 Mar-Apr;3(2):216-30

Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Cambridge, UK.

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June 2011

A Pumilio-induced RNA structure switch in p27-3' UTR controls miR-221 and miR-222 accessibility.

Nat Cell Biol 2010 Oct 5;12(10):1014-20. Epub 2010 Sep 5.

Division of Gene Regulation, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands.

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October 2010

The hinge region of the human estrogen receptor determines functional synergy between AF-1 and AF-2 in the quantitative response to estradiol and tamoxifen.

J Cell Sci 2010 Apr 23;123(Pt 8):1253-61. Epub 2010 Mar 23.

Department of Cell Biology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066CX Amsterdam, The Netherlands.

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April 2010

Perturbation of estrogen receptor alpha localization with synthetic nona-arginine LXXLL-peptide coactivator binding inhibitors.

Chem Biol 2009 Jul;16(7):702-11

Chemical Genomics Centre of the Max Planck Society, 44227 Dortmund, Germany; Laboratory of Chemical Biology, Department of Biomedical Engineering, Eindhoven University of Technology, 5600MB Eindhoven, The Netherlands.

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July 2009

Resistance to antiestrogen arzoxifene is mediated by overexpression of cyclin D1.

Mol Endocrinol 2009 Sep 28;23(9):1335-45. Epub 2009 May 28.

Department of Cell Biology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands.

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September 2009

Classification of anti-estrogens according to intramolecular FRET effects on phospho-mutants of estrogen receptor alpha.

Mol Cancer Ther 2007 May;6(5):1526-33

Division of Tumor Biology, the Netherlands Cancer Institute, Plesmanlaan 121, 1066CX Amsterdam, the Netherlands.

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May 2007

Visualizing the action of steroid hormone receptors in living cells.

Nucl Recept Signal 2007 Mar 9;5:e003. Epub 2007 Mar 9.

Division of Tumor Biology, The Netherlands Cancer Institute, Amsterdam, The Netherlands.

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March 2007

Activation of endosomal dynein motors by stepwise assembly of Rab7-RILP-p150Glued, ORP1L, and the receptor betalll spectrin.

J Cell Biol 2007 Feb 5;176(4):459-71. Epub 2007 Feb 5.

Department of Molecular Medicine, National Public Health Institute, Biomedicum, FI-00251 Helsinki, Finland.

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February 2007

Presenting antigen presentation in living cells using biophysical techniques.

Curr Opin Microbiol 2005 Jun;8(3):338-43

Division of Tumor Biology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands.

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June 2005