Wilbert Zwart

Wilbert Zwart

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Wilbert Zwart

Wilbert Zwart

Publications by authors named "Wilbert Zwart"

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Exogenous ERα Expression in the Mammary Epithelium Decreases Over Time and Does Not Contribute to p53-Deficient Mammary Tumor Formation in Mice.

J Mammary Gland Biol Neoplasia 2019 Dec 15;24(4):305-321. Epub 2019 Nov 15.

Division of Molecular Pathology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066CX, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1007/s10911-019-09437-zDOI Listing
December 2019

Cistrome Partitioning Reveals Convergence of Somatic Mutations and Risk Variants on Master Transcription Regulators in Primary Prostate Tumors.

Cancer Cell 2019 Dec 14;36(6):674-689.e6. Epub 2019 Nov 14.

Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 1L7, Canada; Department of Medical Biophysics, University of Toronto, Toronto, ON M5G 1L7, Canada; Ontario Institute for Cancer Research, Toronto, ON M5G 0A3, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2019.10.005DOI Listing
December 2019

Genomic data integration by WON-PARAFAC identifies interpretable factors for predicting drug-sensitivity in vivo.

Nat Commun 2019 Nov 6;10(1):5034. Epub 2019 Nov 6.

Division of Molecular Carcinogenesis, Oncode Institute, The Netherlands Cancer Institute, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1038/s41467-019-13027-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6834616PMC
November 2019

GATA3 Truncating Mutations Promote Cistromic Re-Programming In Vitro, but Not Mammary Tumor Formation in Mice.

J Mammary Gland Biol Neoplasia 2019 Sep 19;24(3):271-284. Epub 2019 Jun 19.

Division of Molecular Pathology, Oncode Institute, The Netherlands Cancer Institute, Plesmanlaan 121, 1066CX, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1007/s10911-019-09432-4DOI Listing
September 2019

IGF-1R pathway activation as putative biomarker for linsitinib therapy to revert tamoxifen resistance in ER-positive breast cancer.

Int J Cancer 2019 Sep 6. Epub 2019 Sep 6.

Division of Molecular Pathology, The Netherlands Cancer Institute, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1002/ijc.32668DOI Listing
September 2019

CHD1 Loss Alters AR Binding at Lineage-Specific Enhancers and Modulates Distinct Transcriptional Programs to Drive Prostate Tumorigenesis.

Cancer Cell 2019 Apr 28;35(4):603-617.e8. Epub 2019 Mar 28.

Department of Urology, Weill Cornell Medicine, New York, NY 10065, USA; Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, NY 10065, USA; Caryl and Israel Englander Institute for Precision Medicine, Weill Cornell Medicine, New York, NY 10065, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2019.03.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6467783PMC
April 2019

Androgen receptor enhancer usage and the chromatin regulatory landscape in human prostate cancers.

Endocr Relat Cancer 2019 Mar 1. Epub 2019 Mar 1.

W Zwart, Oncogenomics, Antoni van Leeuwenhoek Nederlands Kanker Instituut, Amsterdam, Netherlands.

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http://dx.doi.org/10.1530/ERC-19-0032DOI Listing
March 2019

CUEDC1 is a primary target of ERα essential for the growth of breast cancer cells.

Cancer Lett 2018 11 23;436:87-95. Epub 2018 Aug 23.

Division of Oncogenomics, Oncode Institute, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands; Department of Molecular Genetics, Erasmus University Medical Center, Wytemaweg 80, 3015 CN, Rotterdam, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.canlet.2018.08.018DOI Listing
November 2018

Trophoblast Glycoprotein is Associated With a Favorable Outcome for Mesothelioma and a Target for Antibody Drug Conjugates.

J Thorac Oncol 2018 10 27;13(10):1577-1587. Epub 2018 Jun 27.

Department of Thoracic Oncology, Netherlands Cancer Institute, Amsterdam, The Netherlands. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S15560864183071
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http://dx.doi.org/10.1016/j.jtho.2018.06.008DOI Listing
October 2018

Enzalutamide therapy for advanced prostate cancer: efficacy, resistance and beyond

Endocr Relat Cancer 2018 10 31;26(1):R31-R52. Epub 2018 Oct 31.

Division of Oncogenomics, Oncode Institute, The Netherlands Cancer Institute, Amsterdam, The Netherlands.

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https://erc.bioscientifica.com/view/journals/erc/26/1/ERC-18
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http://dx.doi.org/10.1530/ERC-18-0289DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6215909PMC
October 2018

BRCA1-associated mammary tumorigenesis is dependent on estrogen rather than progesterone signaling.

J Pathol 2018 09 4;246(1):41-53. Epub 2018 Jul 4.

Division of Molecular Pathology, Oncode Institute, The Netherlands Cancer Institute, Amsterdam, The Netherlands.

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http://doi.wiley.com/10.1002/path.5105
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http://dx.doi.org/10.1002/path.5105DOI Listing
September 2018

ERα activity depends on interaction and target site corecruitment with phosphorylated CREB1.

Life Sci Alliance 2018 Jun 7;1(3):e201800055. Epub 2018 Jun 7.

Département de Biologie Cellulaire and Institute of Genetics and Genomics of Geneva, Université de Genève, Genève, Switzerland.

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http://www.life-science-alliance.org/lookup/doi/10.26508/lsa
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http://dx.doi.org/10.26508/lsa.201800055DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6238530PMC
June 2018

Chemical Profiling of Primary Mesothelioma Cultures Defines Subtypes with Different Expression Profiles and Clinical Responses.

Clin Cancer Res 2018 04 24;24(7):1761-1770. Epub 2017 Oct 24.

Department of Chemical Immunology, Leiden University Medical Center, Leiden, the Netherlands.

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http://dx.doi.org/10.1158/1078-0432.CCR-17-1345DOI Listing
April 2018

A review of estrogen receptor/androgen receptor genomics in male breast cancer.

Endocr Relat Cancer 2017 03 6;24(3):R27-R34. Epub 2017 Jan 6.

Division of Molecular Pathologythe Netherlands Cancer Institute, Amsterdam, the Netherlands

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http://dx.doi.org/10.1530/ERC-16-0225DOI Listing
March 2017

The Estrogen Receptor α-Cistrome Beyond Breast Cancer.

Mol Endocrinol 2016 Oct 4;30(10):1046-1058. Epub 2016 Aug 4.

Division of Molecular Pathology, The Netherlands Cancer Institute, 1066 CX Amsterdam, The Netherlands.

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http://dx.doi.org/10.1210/me.2016-1062DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5414603PMC
October 2016

The Effects of Enzalutamide Monotherapy on Multiparametric 3T MR Imaging in Prostate Cancer.

Urol Case Rep 2016 Jul 26;7:67-9. Epub 2016 May 26.

Department of Urology, The Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands.

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http://dx.doi.org/10.1016/j.eucr.2016.04.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4909636PMC
July 2016

Mastermind-Like 3 Controls Proliferation and Differentiation in Neuroblastoma.

Mol Cancer Res 2016 05 19;14(5):411-22. Epub 2016 Jan 19.

Division of Molecular Carcinogenesis, The Netherlands Cancer Institute, Amsterdam, the Netherlands. Cancer Genomics Center Netherlands, The Netherlands Cancer Institute, Amsterdam, the Netherlands.

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http://mcr.aacrjournals.org/content/14/5/411.full-text.pdf
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http://dx.doi.org/10.1158/1541-7786.MCR-15-0291-TDOI Listing
May 2016

The first decade of estrogen receptor cistromics in breast cancer.

J Endocrinol 2016 05 23;229(2):R43-56. Epub 2016 Feb 23.

Division of Molecular PathologyThe Netherlands Cancer Institute, Amsterdam, The Netherlands

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http://dx.doi.org/10.1530/JOE-16-0003DOI Listing
May 2016

Androgen receptor DNA binding and chromatin accessibility profiling in prostate cancer.

Genom Data 2016 Mar 28;7:124-6. Epub 2015 Dec 28.

Division of Molecular Pathology, The Netherlands Cancer Institute, Amsterdam, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands.

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http://dx.doi.org/10.1016/j.gdata.2015.12.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4778643PMC
March 2016

Functional genetic screens for enhancer elements in the human genome using CRISPR-Cas9.

Nat Biotechnol 2016 Feb 11;34(2):192-8. Epub 2016 Jan 11.

Division of Biological Stress Response, the Netherlands Cancer Institute, Amsterdam, the Netherlands.

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http://www.nature.com/articles/nbt.3450
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http://dx.doi.org/10.1038/nbt.3450DOI Listing
February 2016

SRC3 Phosphorylation at Serine 543 Is a Positive Independent Prognostic Factor in ER-Positive Breast Cancer.

Clin Cancer Res 2016 Jan 14;22(2):479-91. Epub 2015 Sep 14.

Department of Molecular and Clinical Cancer Medicine, Institute of Translational Medicine, The University of Liverpool, Liverpool, United Kingdom. Liverpool and Merseyside Academic Breast Unit, The Linda McCartney Centre, Royal Liverpool University Hospital, Liverpool, United Kingdom. Academic Department of Medical Oncology, Clatterbridge Cancer Centre NHS Foundation Trust, Wirral, United Kingdom.

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http://dx.doi.org/10.1158/1078-0432.CCR-14-3277DOI Listing
January 2016

Cognitive effects of endocrine therapy for breast cancer: keep calm and carry on?

Nat Rev Clin Oncol 2015 Oct 21;12(10):597-606. Epub 2015 Jul 21.

Department of Psychosocial Research and Epidemiology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066CX Amsterdam, Netherlands.

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http://dx.doi.org/10.1038/nrclinonc.2015.124DOI Listing
October 2015

Effects of Pharmacogenetics on the Pharmacokinetics and Pharmacodynamics of Tamoxifen.

Clin Pharmacokinet 2015 Aug;54(8):797-810

Department of Pharmacy and Pharmacology, Antoni van Leeuwenhoek-The Netherlands Cancer Institute, Louwesweg 6, 1066 EC, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1007/s40262-015-0273-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4513218PMC
August 2015

Genome-wide epigenetic profiling of breast cancer tumors treated with aromatase inhibitors.

Genom Data 2014 Dec 8;2:195-8. Epub 2014 Jul 8.

Division of Molecular Pathology, Netherlands Cancer Institute, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1016/j.gdata.2014.06.023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4536071PMC
December 2014

Complex formation and function of estrogen receptor α in transcription requires RIP140.

Cancer Res 2014 Oct 21;74(19):5469-79. Epub 2014 Aug 21.

Division of Molecular Pathology, the Netherlands Cancer Institute, Amsterdam, the Netherlands.

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http://dx.doi.org/10.1158/0008-5472.CAN-13-3429DOI Listing
October 2014

Phosphorylation of activating transcription factor-2 (ATF-2) within the activation domain is a key determinant of sensitivity to tamoxifen in breast cancer.

Breast Cancer Res Treat 2014 Sep 22;147(2):295-309. Epub 2014 Aug 22.

Department of Molecular and Clinical Cancer Medicine, Institute of Translational Medicine, University of Liverpool, The Duncan Building, Daulby Street, Liverpool, L69 3GA, UK.

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http://dx.doi.org/10.1007/s10549-014-3098-0DOI Listing
September 2014

USP9X downregulation renders breast cancer cells resistant to tamoxifen.

Cancer Res 2014 Jul;74(14):3810-20

Authors' Affiliations: Division of Molecular Carcinogenesis and Cancer Genomics Center Netherlands; and

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http://dx.doi.org/10.1158/0008-5472.CAN-13-1960DOI Listing
July 2014

Co-regulated gene expression by oestrogen receptor α and liver receptor homolog-1 is a feature of the oestrogen response in breast cancer cells.

Nucleic Acids Res 2013 Dec 17;41(22):10228-40. Epub 2013 Sep 17.

Department of Surgery and Cancer, Imperial College London, London W12 0NN, UK, Department of Molecular Pathology, The Netherlands Cancer Institute, 1066 CX Amsterdam, Netherlands and Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Cambridge CB2 0RE, UK.

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http://dx.doi.org/10.1093/nar/gkt827DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3905875PMC
December 2013

Hallmarks of aromatase inhibitor drug resistance revealed by epigenetic profiling in breast cancer.

Cancer Res 2013 Nov;73(22):6632-41

Authors' Affiliations: Department of Medical Oncology, Erasmus University Medical Center, Cancer Institute, Rotterdam; Departments of Molecular Carcinogenesis and Molecular Pathology, Central Genomic Facility, the Netherlands Cancer Institute; Agendia NV, Amsterdam, the Netherlands; and Translational Cancer Research Unit, Laboratory of Pathology, Antwerp University/Oncology Centre, GZA Hospitals St-Augustinus, Antwerp, Belgium.

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http://dx.doi.org/10.1158/0008-5472.CAN-13-0704DOI Listing
November 2013

Tamoxifen resistance: from bench to bedside.

Eur J Pharmacol 2013 Oct 29;717(1-3):47-57. Epub 2013 Mar 29.

Department of Molecular Pathology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands.

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http://dx.doi.org/10.1016/j.ejphar.2012.11.071DOI Listing
October 2013

Estrogen receptor splice variants as a potential source of false-positive estrogen receptor status in breast cancer diagnostics.

Breast Cancer Res Treat 2013 Aug 4;140(3):475-84. Epub 2013 Aug 4.

Division of Molecular Carcinogenesis, Cancer Genomics Centre, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1007/s10549-013-2648-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3742961PMC
August 2013

A carrier-assisted ChIP-seq method for estrogen receptor-chromatin interactions from breast cancer core needle biopsy samples.

BMC Genomics 2013 Apr 8;14:232. Epub 2013 Apr 8.

Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge, UK.

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http://dx.doi.org/10.1186/1471-2164-14-232DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3637562PMC
April 2013

ChIPing away at breast cancer.

Lancet Oncol 2012 Dec;13(12):1185-7

Ontario Cancer Institute, University Health Network, MARS/TMDT 8-708, Toronto, ON, M5G 1L7, Canada.

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http://dx.doi.org/10.1016/S1470-2045(12)70511-9DOI Listing
December 2012

Can predictive biomarkers in breast cancer guide adjuvant endocrine therapy?

Nat Rev Clin Oncol 2012 Sep 24;9(9):529-41. Epub 2012 Jul 24.

Department of Molecular Pathology, Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands.

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http://dx.doi.org/10.1038/nrclinonc.2012.121DOI Listing
September 2012

TRPM7 is required for breast tumor cell metastasis.

Cancer Res 2012 Aug 7;72(16):4250-61. Epub 2012 Aug 7.

Laboratory of Pediatric Oncology, Department of Cell Biology, Nijmegen Centre for Molecular Life Sciences, Radboud University Medical Centre, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1158/0008-5472.CAN-11-3863DOI Listing
August 2012

A diagnostic gene profile for molecular subtyping of breast cancer associated with treatment response.

Breast Cancer Res Treat 2012 May 4;133(1):37-47. Epub 2011 Aug 4.

Research and Development, Agendia BV, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1007/s10549-011-1683-zDOI Listing
May 2012

Estrogen receptor-positive breast cancer: a multidisciplinary challenge.

Wiley Interdiscip Rev Syst Biol Med 2011 Mar-Apr;3(2):216-30

Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Cambridge, UK.

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http://dx.doi.org/10.1002/wsbm.109DOI Listing
June 2011

A Pumilio-induced RNA structure switch in p27-3' UTR controls miR-221 and miR-222 accessibility.

Nat Cell Biol 2010 Oct 5;12(10):1014-20. Epub 2010 Sep 5.

Division of Gene Regulation, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1038/ncb2105DOI Listing
October 2010

The hinge region of the human estrogen receptor determines functional synergy between AF-1 and AF-2 in the quantitative response to estradiol and tamoxifen.

J Cell Sci 2010 Apr 23;123(Pt 8):1253-61. Epub 2010 Mar 23.

Department of Cell Biology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066CX Amsterdam, The Netherlands.

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http://dx.doi.org/10.1242/jcs.061135DOI Listing
April 2010

Resistance to antiestrogen arzoxifene is mediated by overexpression of cyclin D1.

Mol Endocrinol 2009 Sep 28;23(9):1335-45. Epub 2009 May 28.

Department of Cell Biology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands.

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http://dx.doi.org/10.1210/me.2008-0268DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2737554PMC
September 2009

Perturbation of estrogen receptor alpha localization with synthetic nona-arginine LXXLL-peptide coactivator binding inhibitors.

Chem Biol 2009 Jul;16(7):702-11

Chemical Genomics Centre of the Max Planck Society, 44227 Dortmund, Germany; Laboratory of Chemical Biology, Department of Biomedical Engineering, Eindhoven University of Technology, 5600MB Eindhoven, The Netherlands.

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http://linkinghub.elsevier.com/retrieve/pii/S107455210900207
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http://dx.doi.org/10.1016/j.chembiol.2009.06.009DOI Listing
July 2009

Classification of anti-estrogens according to intramolecular FRET effects on phospho-mutants of estrogen receptor alpha.

Mol Cancer Ther 2007 May;6(5):1526-33

Division of Tumor Biology, the Netherlands Cancer Institute, Plesmanlaan 121, 1066CX Amsterdam, the Netherlands.

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http://dx.doi.org/10.1158/1535-7163.MCT-06-0750DOI Listing
May 2007

Visualizing the action of steroid hormone receptors in living cells.

Nucl Recept Signal 2007 Mar 9;5:e003. Epub 2007 Mar 9.

Division of Tumor Biology, The Netherlands Cancer Institute, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1621/nrs.05003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1853070PMC
March 2007

Presenting antigen presentation in living cells using biophysical techniques.

Curr Opin Microbiol 2005 Jun;8(3):338-43

Division of Tumor Biology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands.

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http://dx.doi.org/10.1016/j.mib.2005.04.007DOI Listing
June 2005