Wiesje van der Flier

Wiesje van der Flier

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Wiesje van der Flier

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Decision tree supports the interpretation of CSF biomarkers in Alzheimer's disease.

Alzheimers Dement (Amst) 2019 Dec 12;11:1-9. Epub 2018 Nov 12.

Neurochemistry Laboratory, Department of Clinical Chemistry, Amsterdam Neuroscience, VU University Medical Center, Amsterdam UMC, Amsterdam, the Netherlands.

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http://dx.doi.org/10.1016/j.dadm.2018.10.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6287084PMC
December 2019

Cerebrospinal fluid collection: An informative animation video for patients and caregivers.

Alzheimers Dement (Amst) 2019 Dec 12;11:435-438. Epub 2019 Jun 12.

Neurochemistry Laboratory and Biobank, Department of Clinical Chemistry, Amsterdam Neuroscience, VU University Medical Center Amsterdam, Amsterdam UMC, Amsterdam, the Netherlands.

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http://dx.doi.org/10.1016/j.dadm.2019.04.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6562320PMC
December 2019

Added value of amyloid PET in individualized risk predictions for MCI patients.

Alzheimers Dement (Amst) 2019 Dec 29;11:529-537. Epub 2019 Jul 29.

Department of Neurology, Alzheimer Center Amsterdam, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1016/j.dadm.2019.04.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6667768PMC
December 2019

Pre-analytical stability of novel cerebrospinal fluid biomarkers.

Clin Chim Acta 2019 Oct 23;497:204-211. Epub 2019 Jul 23.

Neurochemistry laboratory, Department of Clinical Chemistry, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam Neuroscience, the Netherlands; Head of Biobank, Department of Clinical Chemistry, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam Neuroscience, the Netherlands.

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http://dx.doi.org/10.1016/j.cca.2019.07.024DOI Listing
October 2019

Test-retest repeatability of [F]Flortaucipir PET in Alzheimer's disease and cognitively normal individuals.

J Cereb Blood Flow Metab 2019 Oct 1:271678X19879226. Epub 2019 Oct 1.

Department of Radiology & Nuclear Medicine, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1177/0271678X19879226DOI Listing
October 2019

Assessment of the appropriate use criteria for amyloid PET in an unselected memory clinic cohort: The ABIDE project.

Alzheimers Dement 2019 Oct 6. Epub 2019 Oct 6.

Department of Neurology, Amsterdam Neuroscience, Alzheimer Center, VU University, Amsterdam UMC, Amsterdam, the Netherlands; Department of Epidemiology and Biostatistics, Amsterdam Neuroscience, VU University of Amsterdam, Amsterdam, the Netherlands.

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http://dx.doi.org/10.1016/j.jalz.2019.07.003DOI Listing
October 2019

Applying the ATN scheme in a memory clinic population: The ABIDE project.

Neurology 2019 Oct 9. Epub 2019 Oct 9.

From the Alzheimer Center Amsterdam, Department of Neurology (D.A., A.d.W., R.O., W.P., F.B., C.G., I.v.M., M.Z., B.N.v.B., P.S., W.M.v.d.F.), Department of Radiology & Nuclear Medicine (R.O., C.G., M.Y., F.B., B.N.v.B.), and Neurochemistry Laboratory, Department of Clinical Chemistry (C.E.T.), Amsterdam Neuroscience, and Department of Epidemiology & Biostatistics (I.v.M., W.M.v.d.F.), Vrije Universiteit Amsterdam, Amsterdam UMC, the Netherlands; Laboratory of Neuroimaging of Aging (LANVIE) (D.A., G.B.F.), University of Geneva, Switzerland; Memory Clinic (D.A.), University Hospitals of Geneva, Switzerland; Laboratory of Alzheimer's Neuroimaging and Epidemiology (LANE) (D.A.), Saint John of God Clinical Research Centre; Department of Molecular and Translational Medicine (D.A.), University of Brescia, Italy; Clinical Memory Research Unit (R.O.), Lund University, Malmö, Sweden; Institutes of Neurology and Healthcare Engineering (F.B.), UCL, London, UK; and Memory Clinic (G.B.F.), University Hospitals of Geneva, Switzerland.

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http://dx.doi.org/10.1212/WNL.0000000000008361DOI Listing
October 2019

Amyloid-β peptides in cerebrospinal fluid of patients with dementia with Lewy bodies.

Alzheimers Res Ther 2019 Oct 10;11(1):83. Epub 2019 Oct 10.

Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, De Boelelaan 1118, 1081 HV, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1186/s13195-019-0537-5DOI Listing
October 2019

Gray matter T1-w/T2-w ratios are higher in Alzheimer's disease.

Hum Brain Mapp 2019 Sep 3;40(13):3900-3909. Epub 2019 Jun 3.

Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1002/hbm.24638DOI Listing
September 2019

Discordant amyloid-β PET and CSF biomarkers and its clinical consequences.

Alzheimers Res Ther 2019 Sep 12;11(1):78. Epub 2019 Sep 12.

Department of Neurology & Alzheimer Center, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, P.O. Box 7057, 1007 MB, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1186/s13195-019-0532-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6739952PMC
September 2019

VGF Peptides in Cerebrospinal Fluid of Patients with Dementia with Lewy Bodies.

Int J Mol Sci 2019 Sep 20;20(19). Epub 2019 Sep 20.

Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, 1081 HV Amsterdam, The Netherlands.

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http://dx.doi.org/10.3390/ijms20194674DOI Listing
September 2019

High amyloid burden is associated with fewer specific words during spontaneous speech in individuals with subjective cognitive decline.

Neuropsychologia 2019 Aug 7;131:184-192. Epub 2019 May 7.

Department of Radiology & Nuclear Medicine, Amsterdam University Medical Center, location VUmc, Amsterdam, the Netherlands; Department of Epidemiology & Biostatistics, Amsterdam University Medical Center, location VUmc, Amsterdam, the Netherlands; Amsterdam Neuroscience, Amsterdam, the Netherlands.

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http://dx.doi.org/10.1016/j.neuropsychologia.2019.05.006DOI Listing
August 2019

A nonsynonymous mutation in PLCG2 reduces the risk of Alzheimer's disease, dementia with Lewy bodies and frontotemporal dementia, and increases the likelihood of longevity.

Authors:
Sven J van der Lee Olivia J Conway Iris Jansen Minerva M Carrasquillo Luca Kleineidam Erik van den Akker Isabel Hernández Kristel R van Eijk Najada Stringa Jason A Chen Anna Zettergren Till F M Andlauer Monica Diez-Fairen Javier Simon-Sanchez Alberto Lleó Henrik Zetterberg Marianne Nygaard Cornelis Blauwendraat Jeanne E Savage Jonas Mengel-From Sonia Moreno-Grau Michael Wagner Juan Fortea Michael J Keogh Kaj Blennow Ingmar Skoog Manuel A Friese Olga Pletnikova Miren Zulaica Carmen Lage Itziar de Rojas Steffi Riedel-Heller Ignacio Illán-Gala Wei Wei Bernard Jeune Adelina Orellana Florian Then Bergh Xue Wang Marc Hulsman Nina Beker Niccolo Tesi Christopher M Morris Begoña Indakoetxea Lyduine E Collij Martin Scherer Estrella Morenas-Rodríguez James W Ironside Bart N M van Berckel Daniel Alcolea Heinz Wiendl Samantha L Strickland Pau Pastor Eloy Rodríguez Rodríguez Bradley F Boeve Ronald C Petersen Tanis J Ferman Jay A van Gerpen Marcel J T Reinders Ryan J Uitti Lluís Tárraga Wolfgang Maier Oriol Dols-Icardo Amit Kawalia Maria Carolina Dalmasso Mercè Boada Uwe K Zettl Natasja M van Schoor Marian Beekman Mariet Allen Eliezer Masliah Adolfo López de Munain Alexander Pantelyat Zbigniew K Wszolek Owen A Ross Dennis W Dickson Neill R Graff-Radford David Knopman Rosa Rademakers Afina W Lemstra Yolande A L Pijnenburg Philip Scheltens Thomas Gasser Patrick F Chinnery Bernhard Hemmer Martijn A Huisman Juan Troncoso Fermin Moreno Ellen A Nohr Thorkild I A Sørensen Peter Heutink Pascual Sánchez-Juan Danielle Posthuma Jordi Clarimón Kaare Christensen Nilüfer Ertekin-Taner Sonja W Scholz Alfredo Ramirez Agustín Ruiz Eline Slagboom Wiesje M van der Flier Henne Holstege

Acta Neuropathol 2019 Aug 27;138(2):237-250. Epub 2019 May 27.

Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1007/s00401-019-02026-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6660501PMC
August 2019

A meta-analysis of genome-wide association studies identifies multiple longevity genes.

Nat Commun 2019 Aug 14;10(1):3669. Epub 2019 Aug 14.

NHLBI's and Boston University's Framingham Heart Study, Framingham, MA, 01702, USA.

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http://dx.doi.org/10.1038/s41467-019-11558-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6694136PMC
August 2019

ABIDE Delphi study: topics to discuss in diagnostic consultations in memory clinics.

Alzheimers Res Ther 2019 Aug 31;11(1):77. Epub 2019 Aug 31.

Department of Medical Psychology, Amsterdam Public Health Research Institute, University of Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1186/s13195-019-0531-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6717649PMC
August 2019

Disease Course Varies According to Age and Symptom Length in Alzheimer's Disease.

J Alzheimers Dis 2018 ;64(2):631-642

Department of Medical Statistics, Faculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, UK.

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http://dx.doi.org/10.3233/JAD-170841DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6207933PMC
July 2019

Impact of white matter hyperintensity location on depressive symptoms in memory-clinic patients: a lesion–symptom mapping study

J Psychiatry Neurosci 2019 07;44(4):E1-E10

From the Alzheimer Centre Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, the Netherlands (Leeuwis, Hooghiemstra, Prins, Scheltens, van der Flier); the Department of Neurology, Brain Centre Rudolf Magnus, University Medical Centre Utrecht, Utrecht, the Netherlands (Weaver, Biesbroek, Exalto, Biessels); the Image Sciences Institute, University Medical Centre Utrecht, Utrecht, the Netherlands (Kuijf); the Department of Medical Humanities, Amsterdam Public Health Research Institute, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands (Hooghiemstra); the Institutes of Neurology and Healthcare Engineering, UCL, London, United Kingdom (Barkhof); the Department of Radiology and Nuclear Medicine, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands (Barkhof); and the Department of Epidemiology & Biostatistics, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands (Flier).

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http://dx.doi.org/10.1503/jpn.180136DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6606429PMC
July 2019

ApoE and clusterin CSF levels influence associations between APOE genotype and changes in CSF tau, but not CSF Aβ42, levels in non-demented elderly.

Neurobiol Aging 2019 07 1;79:101-109. Epub 2019 Mar 1.

Department of Clinical Chemistry, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands; Department of Psychiatry, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1016/j.neurobiolaging.2019.02.017DOI Listing
July 2019

Duration of preclinical, prodromal, and dementia stages of Alzheimer's disease in relation to age, sex, and APOE genotype.

Alzheimers Dement 2019 Jul 1;15(7):888-898. Epub 2019 Jun 1.

Department of Neurology, Alzheimer Center Amsterdam, Amsterdam Neuroscience, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands; Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience (MHeNS), Alzheimer Centrum Limburg, Maastricht University, Maastricht, The Netherlands.

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http://dx.doi.org/10.1016/j.jalz.2019.04.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6646097PMC
July 2019

Cognitive reserve and clinical progression in Alzheimer disease: A paradoxical relationship.

Neurology 2019 Jul 2;93(4):e334-e346. Epub 2019 Jul 2.

From Alzheimer Center Amsterdam, Department of Neurology (A.C.v.L., W.M.v.d.F., E.D., C.G., P.S., R.O.), and Department of Radiology and Nuclear Medicine (A.M.W., F.B., R.O.), Amsterdam Neuroscience, and Department of Epidemiology and Biostatistics (W.M.v.d.F., J.T.), Vrije Universiteit Amsterdam, Amsterdam UMC, the Netherlands; Institutes of Neurology and Healthcare Engineering (F.B.), University College London, UK; and Clinical Memory Research Unit (R.O.), Lund University, Sweden.

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http://dx.doi.org/10.1212/WNL.0000000000007821DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6669930PMC
July 2019

Survival in memory clinic cohort is short, even in young-onset dementia.

J Neurol Neurosurg Psychiatry 2019 Jun 25;90(6):726-728. Epub 2018 Jul 25.

Alzheimer Center, Department of Neurology, VU University Medical Centre, Amsterdam Neuroscience, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1136/jnnp-2018-318820DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6581097PMC
June 2019

Amsterdam Dementia Cohort: Performing Research to Optimize Care.

J Alzheimers Dis 2018 ;62(3):1091-1111

Department of Neurology, Alzheimer Center, VU University Medical Center, Amsterdam Neuroscience, Amsterdam, The Netherlands.

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http://dx.doi.org/10.3233/JAD-170850DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5870023PMC
May 2019

Clinical relevance of acute cerebral microinfarcts in vascular cognitive impairment.

Neurology 2019 Apr 8;92(14):e1558-e1566. Epub 2019 Mar 8.

From the Department of Neurology (D.A.F., H.v.d.B., L.G.E., J.M.F.B., G.J.B.), Brain Center UMC Utrecht, University Medical Center Utrecht, Utrecht University; Department of Neurology (J.M.F.B.), Onze Lieve Vrouwe Gasthuis (OLVG) West; Department of Radiology & Nuclear Medicine (F.B.) Department of Neurology and Alzheimer Center Amsterdam (N.D.P., W.M.v.d.F.), Department of Epidemiology & Biostatistics (W.M.v.d.F.), Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, the Netherlands; and Institutes of Neurology and Healthcare Engineering (F.B.), University College London, UK.

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http://dx.doi.org/10.1212/WNL.0000000000007250DOI Listing
April 2019

Web-Based Multidomain Lifestyle Programs for Brain Health: Comprehensive Overview and Meta-Analysis.

JMIR Ment Health 2019 Apr 9;6(4):e12104. Epub 2019 Apr 9.

Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, Netherlands.

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http://dx.doi.org/10.2196/12104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6477576PMC
April 2019

Modeling grey matter atrophy as a function of time, aging or cognitive decline show different anatomical patterns in Alzheimer's disease.

Neuroimage Clin 2019 19;22:101786. Epub 2019 Mar 19.

Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Amsterdam UMC, Amsterdam, the Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.nicl.2019.101786DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6439228PMC
March 2019

The Impact of Frailty and Comorbidity on Institutionalization and Mortality in Persons With Dementia: A Prospective Cohort Study.

J Am Med Dir Assoc 2019 Feb 23;20(2):165-170.e2. Epub 2018 Aug 23.

Radboud university medical center, Radboud Institute for Health Sciences, Department of Geriatric Medicine, Radboudumc Alzheimer Center, Nijmegen, The Netherlands. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S15258610183035
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http://dx.doi.org/10.1016/j.jamda.2018.06.020DOI Listing
February 2019

Data-driven approaches for tau-PET imaging biomarkers in Alzheimer's disease.

Hum Brain Mapp 2019 Feb 19;40(2):638-651. Epub 2018 Oct 19.

Alzheimer Center and Department of Neurology, VU University Medical Center, Amsterdam Neuroscience, Amsterdam, Netherlands.

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http://dx.doi.org/10.1002/hbm.24401DOI Listing
February 2019

Energy and Protein Intake of Alzheimer's Disease Patients Compared to Cognitively Normal Controls: Systematic Review.

J Am Med Dir Assoc 2019 Jan 9;20(1):14-21. Epub 2018 Aug 9.

Department of Nutrition and Dietetics, Internal Medicine, VU University Medical Center, Amsterdam, the Netherlands; Department of Nutrition and Health, HAN University of Applied Sciences, Nijmegen, the Netherlands.

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http://dx.doi.org/10.1016/j.jamda.2018.06.019DOI Listing
January 2019

Repeat length variations in ATXN1 and AR modify disease expression in Alzheimer's disease.

Neurobiol Aging 2019 01 15;73:230.e9-230.e17. Epub 2018 Sep 15.

Departments of Neurology, Leiden University Medical Centre, Leiden, the Netherlands; German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.

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http://dx.doi.org/10.1016/j.neurobiolaging.2018.09.007DOI Listing
January 2019

Nature and implications of sex differences in AD pathology.

Nat Rev Neurol 2019 Jan;15(1):6-8

Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, Netherlands.

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http://dx.doi.org/10.1038/s41582-018-0115-7DOI Listing
January 2019

The Clinical Phenotype of Vascular Cognitive Impairment in Patients with Type 2 Diabetes Mellitus.

J Alzheimers Dis 2019 ;68(1):311-322

Department of Neurology, Brain Center Rudolph Magnus, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.

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http://dx.doi.org/10.3233/JAD-180914DOI Listing
January 2019

Trajectories and Determinants of Quality of Life in Dementia with Lewy Bodies and Alzheimer's Disease.

J Alzheimers Dis 2019 ;70(2):389-397

Department of Neurology, Alzheimer Center Amsterdam, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands.

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http://dx.doi.org/10.3233/JAD-190041DOI Listing
January 2019

Orthostatic Hypotension: An Important Risk Factor for Clinical Progression to Mild Cognitive Impairment or Dementia. The Amsterdam Dementia Cohort.

J Alzheimers Dis 2019 ;71(1):317-325

Department of Internal Medicine and Geriatrics, Amsterdam UMC, location VUmc, Amsterdam Cardiovascular Sciences, Amsterdam, the Netherlands.

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http://dx.doi.org/10.3233/JAD-190402DOI Listing
January 2019

Atrophy subtypes in prodromal Alzheimer's disease are associated with cognitive decline.

Brain 2018 12;141(12):3443-3456

Alzheimer Center and Department of Neurology, Neuroscience Campus Amsterdam, VU University Medical Center, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1093/brain/awy264DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6669409PMC
December 2018

Angiopoietin like-4 as a novel vascular mediator in capillary cerebral amyloid angiopathy.

Brain 2018 12;141(12):3377-3388

Amsterdam UMC, Vrije Universiteit Amsterdam, Department of Molecular Cell Biology and Immunology, Amsterdam Neuroscience, The Netherlands.

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http://dx.doi.org/10.1093/brain/awy274DOI Listing
December 2018

Prevalence of amyloid-β pathology in distinct variants of primary progressive aphasia.

Ann Neurol 2018 11;84(5):729-740

Alzheimer center Amsterdam, Amsterdam UMC, Amsterdam Neuroscience, VU University, Amsterdam, the Netherlands.

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http://dx.doi.org/10.1002/ana.25333DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354051PMC
November 2018

Clinical phenotype, atrophy, and small vessel disease in ε2 carriers with Alzheimer disease.

Neurology 2018 11 19;91(20):e1851-e1859. Epub 2018 Oct 19.

From the Departments of Neurology and Alzheimer Center (C.G., P.S., W.M.v.d.F., R.O.), Radiology and Nuclear Medicine (C.G., F.B., B.N.M.v.B., R.O.), Neurochemistry Lab and Biobank (C.E.T.), and Clinical Chemistry, Epidemiology and Biostatistics (W.M.v.d.F.), VU University Medical Center, Neuroscience Campus Amsterdam, the Netherlands; Dementia Research Centre (C.H.S., S.O., M.J.C.), Department of Neurodegenerative Disease, UCL Institute of Neurology, Centre for Medical Image Computing (C.H.S., S.O., M.J.C.), and Institutes of Neurology & Healthcare Engineering (F.B.), University College London, UK; Department of Neurology (S.W.S.), Sungkyunkwan University School of Medicine, and Neuroscience Center (S.W.S.), Samsung Medical Center; Department of Clinical Research Design & Evaluation (S.W.S.), SAIHST, Sungkyunkwan University, Seoul, Korea; and Clinical Memory Research Unit (R.O.), Lund University, Sweden.

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http://www.neurology.org/lookup/doi/10.1212/WNL.000000000000
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http://dx.doi.org/10.1212/WNL.0000000000006503DOI Listing
November 2018

α-Synuclein species as potential cerebrospinal fluid biomarkers for dementia with lewy bodies.

Mov Disord 2018 11 15;33(11):1724-1733. Epub 2018 Nov 15.

Neurological Disorders Research Center, Qatar Biomedical Research Institute (QBRI), Hamad Bin Khalifa University (HBKU), Qatar Foundation, Doha, Qatar.

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http://doi.wiley.com/10.1002/mds.111
Publisher Site
http://dx.doi.org/10.1002/mds.111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6519232PMC
November 2018

Is intracranial volume a suitable proxy for brain reserve?

Alzheimers Res Ther 2018 09 11;10(1):91. Epub 2018 Sep 11.

Department of Neurology and Alzheimer Center, Neuroscience Campus Amsterdam, VU University Medical Center, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1186/s13195-018-0408-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6134772PMC
September 2018

Pre-amyloid stage of Alzheimer's disease in cognitively normal individuals.

Ann Clin Transl Neurol 2018 Sep 20;5(9):1037-1047. Epub 2018 Jul 20.

Alzheimer Center Department of Neurology VU University Medical Center Amsterdam Neuroscience Amsterdam The Netherlands.

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http://dx.doi.org/10.1002/acn3.615DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6144448PMC
September 2018

Subjective Cognitive Impairment Cohort (SCIENCe): study design and first results.

Alzheimers Res Ther 2018 08 7;10(1):76. Epub 2018 Aug 7.

Alzheimer Center and Department of Neurology, Amsterdam Neuroscience, Amsterdam University Medical Centers, Vrije Universiteit, De Boelelaan 1118, 1081 HZ, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1186/s13195-018-0390-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6080529PMC
August 2018

Prevalence of the apolipoprotein E ε4 allele in amyloid β positive subjects across the spectrum of Alzheimer's disease.

Authors:
Niklas Mattsson Colin Groot Willemijn J Jansen Susan M Landau Victor L Villemagne Sebastiaan Engelborghs Mark M Mintun Alberto Lleo José Luis Molinuevo William J Jagust Giovanni B Frisoni Adrian Ivanoiu Gaël Chételat Catarina Resende de Oliveira Karen M Rodrigue Johannes Kornhuber Anders Wallin Aleksandra Klimkowicz-Mrowiec Ramesh Kandimalla Julius Popp Pauline P Aalten Dag Aarsland Daniel Alcolea Ina S Almdahl Inês Baldeiras Mark A van Buchem Enrica Cavedo Kewei Chen Ann D Cohen Stefan Förster Juan Fortea Kristian S Frederiksen Yvonne Freund-Levi Kiran Dip Gill Olymbia Gkatzima Timo Grimmer Harald Hampel Sanna-Kaisa Herukka Peter Johannsen Koen van Laere Mony J de Leon Wolfgang Maier Jan Marcusson Olga Meulenbroek Hanne M Møllergård John C Morris Barbara Mroczko Arto Nordlund Sudesh Prabhakar Oliver Peters Lorena Rami Eloy Rodríguez-Rodríguez Catherine M Roe Eckart Rüther Isabel Santana Johannes Schröder Sang W Seo Hilkka Soininen Luiza Spiru Erik Stomrud Hanne Struyfs Charlotte E Teunissen Frans R J Verhey Stephanie J B Vos Linda J C van Waalwijk van Doorn Gunhild Waldemar Åsa K Wallin Jens Wiltfang Rik Vandenberghe David J Brooks Tormod Fladby Christopher C Rowe Alexander Drzezga Marcel M Verbeek Marie Sarazin David A Wolk Adam S Fleisher William E Klunk Duk L Na Pascual Sánchez-Juan Dong Young Lee Agneta Nordberg Magda Tsolaki Vincent Camus Juha O Rinne Anne M Fagan Henrik Zetterberg Kaj Blennow Gil D Rabinovici Oskar Hansson Bart N M van Berckel Wiesje M van der Flier Philip Scheltens Pieter Jelle Visser Rik Ossenkoppele

Alzheimers Dement 2018 07 28;14(7):913-924. Epub 2018 Mar 28.

Clinical Memory Research Unit, Clinical Sciences Malmö, Lund University, Lund, Sweden; Department of Neurology and Alzheimer Center, VU University Medical Center, Neuroscience Campus Amsterdam, Amsterdam, the Netherlands; Department of Radiology and Nuclear Medicine, VU University Medical Center, Neuroscience Campus Amsterdam, Amsterdam, the Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.jalz.2018.02.009DOI Listing
July 2018

Disclosure of amyloid positron emission tomography results to individuals without dementia: a systematic review.

Alzheimers Res Ther 2018 07 28;10(1):72. Epub 2018 Jul 28.

Department of Neurology & Alzheimer Center, Amsterdam Neuroscience, VU University Medical Center, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1186/s13195-018-0398-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6064628PMC
July 2018

Neurogranin as Cerebrospinal Fluid Biomarker for Alzheimer Disease: An Assay Comparison Study.

Clin Chem 2018 06 9;64(6):927-937. Epub 2018 Mar 9.

Neurochemistry laboratory, Department of Clinical Chemistry, Amsterdam Neuroscience, VU University Medical Center Amsterdam, the Netherlands.

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http://dx.doi.org/10.1373/clinchem.2017.283028DOI Listing
June 2018

European Prevention of Alzheimer's Dementia Registry: Recruitment and prescreening approach for a longitudinal cohort and prevention trials.

Alzheimers Dement 2018 06 28;14(6):837-842. Epub 2018 Mar 28.

Department of Neurology and Alzheimer Center, Amsterdam Neuroscience, VU University Medical Center, Amsterdam, The Netherlands; Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Alzheimer Centre Limburg, Maastricht University, Maastricht, The Netherlands.

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http://dx.doi.org/10.1016/j.jalz.2018.02.010DOI Listing
June 2018

Contactin-2, a synaptic and axonal protein, is reduced in cerebrospinal fluid and brain tissue in Alzheimer's disease.

Alzheimers Res Ther 2018 06 1;10(1):52. Epub 2018 Jun 1.

Neurochemistry Laboratory, Clinical Chemistry Department, VU University Medical Center, De Boelelaan 1117, 1081 HV, Amsterdam, the Netherlands.

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http://dx.doi.org/10.1186/s13195-018-0383-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5984818PMC
June 2018

Quantification of [F]florbetapir: A test-retest tracer kinetic modelling study.

J Cereb Blood Flow Metab 2018 06 13:271678X18783628. Epub 2018 Jun 13.

1 Department of Radiology & Nuclear Medicine, Amsterdam Neuroscience, VU University Medical Center, Amsterdam, the Netherlands.

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http://dx.doi.org/10.1177/0271678X18783628DOI Listing
June 2018

Vascular Endothelial Growth Factor remains unchanged in cerebrospinal fluid of patients with Alzheimer's disease and vascular dementia.

Alzheimers Res Ther 2018 06 23;10(1):58. Epub 2018 Jun 23.

Department of Molecular Cell Biology and Immunology, Amsterdam Neuroscience, VU University Medical Center, De Boelelaan 1108, 1007 MB, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1186/s13195-018-0385-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6015445PMC
June 2018

Subjective Cognitive Decline Is Associated With Altered Default Mode Network Connectivity in Individuals With a Family History of Alzheimer's Disease.

Biol Psychiatry Cogn Neurosci Neuroimaging 2018 05 14;3(5):463-472. Epub 2017 Dec 14.

Montreal Neurological Institute, Montreal, Quebec, Canada; Centre for the Studies on Prevention of Alzheimer's Disease, Douglas Mental Health University Institute Research Centre, Montreal, Quebec, Canada; Department of Psychiatry, McGill University, Montreal, Quebec, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.bpsc.2017.11.012DOI Listing
May 2018

Clinical value of neurofilament and phospho-tau/tau ratio in the frontotemporal dementia spectrum.

Neurology 2018 04 7;90(14):e1231-e1239. Epub 2018 Mar 7.

From the Alzheimer Center and Department of Neurology (L.H.H.M., L.D.K., F.J.d.J., J.C.v.S.), Erasmus Medical Center, Rotterdam; Alzheimer Center and Department of Neurology (E.G.V., W.M.v.d.F., Y.A.L.P.), Neurochemistry Laboratory, Department of Clinical Chemistry (M.D.C., C.E.T.), Department of Pathology (A.J.M.R.), and Department of Clinical Genetics (J.C.v.S.), Neuroscience Campus Amsterdam, VU University Medical Center, Amsterdam, the Netherlands.

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http://dx.doi.org/10.1212/WNL.0000000000005261DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5890612PMC
April 2018

Gray Matter Network Disruptions and Regional Amyloid Beta in Cognitively Normal Adults.

Front Aging Neurosci 2018 15;10:67. Epub 2018 Mar 15.

Alzheimer Center & Department of Neurology, Amsterdam Neuroscience, VU University Medical Center, Amsterdam, Netherlands.

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http://dx.doi.org/10.3389/fnagi.2018.00067DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5863592PMC
March 2018

Vascular cognitive impairment.

Nat Rev Dis Primers 2018 02 15;4:18003. Epub 2018 Feb 15.

Alzheimer Center, Department of Neurology, Amsterdam Neuroscience, VU University Medical Center, de Boelelaan 1118, 1081 HZ Amsterdam, Netherlands.

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http://dx.doi.org/10.1038/nrdp.2018.3DOI Listing
February 2018

Disease-related determinants are associated with mortality in dementia due to Alzheimer's disease.

Alzheimers Res Ther 2018 02 20;10(1):23. Epub 2018 Feb 20.

Alzheimer Center, Department of Neurology, VU University Medical Center, Amsterdam Neuroscience, P.O. Box 7057, 1007, MB, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1186/s13195-018-0348-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5819199PMC
February 2018

Differential effects of cognitive reserve and brain reserve on cognition in Alzheimer disease.

Neurology 2018 01 13;90(2):e149-e156. Epub 2017 Dec 13.

From the Department of Neurology and Alzheimer Center (C.G., A.C.v.L., P.S., W.M.v.d.F., R.O.) and Departments of Radiology and Nuclear Medicine (C.G., F.B., B.N.M.v.B., R.O.), Medical Psychology (T.K.), Clinical Chemistry (C.C.T.), and Epidemiology and Biostatistics (W.M.v.d.F.), VU University Medical Center, Amsterdam, the Netherlands; and Institutes of Neurology & Healthcare Engineering (F.B.), University College London, UK.

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http://dx.doi.org/10.1212/WNL.0000000000004802DOI Listing
January 2018

Synaptic proteins in CSF as potential novel biomarkers for prognosis in prodromal Alzheimer's disease.

Alzheimers Res Ther 2018 01 15;10(1). Epub 2018 Jan 15.

Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden.

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http://dx.doi.org/10.1186/s13195-017-0335-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6389073PMC
January 2018

Microbleeds are associated with depressive symptoms in Alzheimer's disease.

Alzheimers Dement (Amst) 2018 6;10:112-120. Epub 2017 Dec 6.

Alzheimer Center and Department of Neurology, Amsterdam Neuroscience, VU University Medical Center, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1016/j.dadm.2017.11.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5956804PMC
December 2017