Werner Streicher

Department of Pharmacy, Pharmaceutical Technology and Biopharmaceutics , Ludwig-Maximilians-Universitaet Muenchen , Butenandtstrasse 5 , 81377 Munich , Germany.

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February 2020

Characterization of Native Reversible Self-Association of a Monoclonal Antibody Mediated by Fab-Fab Interaction.

Authors:

Lorenzo Gentiluomo Dierk Roessner Werner Streicher Sujata Mahapatra Pernille Harris Wolfgang Frieß

J Pharm Sci 2020 01 26;109(1):443-451. Epub 2019 Sep 26.

Department of Pharmacy, Pharmaceutical Technology and Biopharmaceutics, Ludwig-Maximilians-Universitaet Muenchen, Butenandtstrasse 5, 81377 Munich, Germany.

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January 2020

Novel non-linear curve fitting to resolve protein unfolding transitions in intrinsic fluorescence differential scanning fluorimetry.

Authors:

Dillen Augustijn Sujata Mahapatra Werner Streicher Hristo Svilenov Alina Kulakova Christin Pohl Åsmund Rinnan

Eur J Pharm Biopharm 2019 Sep 6;142:506-517. Epub 2019 Jun 6.

Department of Food Science, Faculty of Life Sciences, University of Copenhagen, Rolighedsvej 30, DK-1958 Frederiksberg C, Denmark.

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September 2019

Application of interpretable artificial neural networks to early monoclonal antibodies development.

Authors:

Lorenzo Gentiluomo Dierk Roessner Dillen Augustijn Hristo Svilenov Alina Kulakova Sujata Mahapatra Gerhard Winter Werner Streicher Åsmund Rinnan Günther H J Peters Pernille Harris Wolfgang Frieß

Eur J Pharm Biopharm 2019 Aug 18;141:81-89. Epub 2019 May 18.

Ludwig Maximilians-Universität München, Department of Pharmacy, Pharmaceutical Technology and Biopharmaceutics, Butenandtstrasse 5, 81377 Munich, Germany.

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August 2019

Conformational Stability Study of a Therapeutic Peptide Plectasin Using Molecular Dynamics Simulations in Combination with NMR.

Authors:

Sowmya Indrakumar Matja Zalar Christin Pohl Allan Nørgaard Werner Streicher Pernille Harris Alexander P Golovanov Günther H J Peters

J Phys Chem B 2019 06 31;123(23):4867-4877. Epub 2019 May 31.

Department of Chemistry , Technical University of Denmark , Kgs. Lyngby 2800 , Denmark.

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June 2019

A novel TPR-BEN domain interaction mediates PICH-BEND3 association.

Authors:

Ganesha P Pitchai Manuel Kaulich Anna H Bizard Pablo Mesa Qi Yao Kata Sarlos Werner W Streicher Erich A Nigg Guillermo Montoya Ian D Hickson

Nucleic Acids Res 2017 Nov;45(19):11413-11424

Center for Chromosome Stability and Center for Healthy Aging, Department of Cellular and Molecular Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Blegdamsvej 3B, 2200 Copenhagen, Denmark.

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November 2017

Characterization of the NTPR and BD1 interacting domains of the human PICH-BEND3 complex.

Authors:

Ganesha P Pitchai Ian D Hickson Werner Streicher Guillermo Montoya Pablo Mesa

Acta Crystallogr F Struct Biol Commun 2016 08 27;72(Pt 8):646-51. Epub 2016 Jul 27.

Protein Structure and Function Programme, Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Blegdamsvej 3b, 2200 Copenhagen, Denmark.

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August 2016

Structural Analysis of a Complex between Small Ubiquitin-like Modifier 1 (SUMO1) and the ZZ Domain of CREB-binding Protein (CBP/p300) Reveals a New Interaction Surface on SUMO.

Authors:

Carl Diehl Mikael Akke Simon Bekker-Jensen Niels Mailand Werner Streicher Mats Wikström

J Biol Chem 2016 Jun 25;291(24):12658-72. Epub 2016 Apr 25.

From the Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, DK-2200 Copenhagen, Denmark, Amgen Inc., Thousand Oaks, California 91320

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June 2016

Conformation-specific anti-Mad2 monoclonal antibodies for the dissection of checkpoint signaling.

Authors:

Garry G Sedgwick Marie Sofie Yoo Larsen Tiziana Lischetti Werner Streicher Rosa Rakownikow Jersie-Christensen Jesper V Olsen Jakob Nilsson

MAbs 2016 May-Jun;8(4):689-97. Epub 2016 Mar 17.

a The Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen , Copenhagen , Denmark.

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November 2017

Structure and Interactions of a Dimeric Variant of sHIP, a Novel Virulence Determinant of Streptococcus pyogenes.

Authors:

Carl Diehl Magdalena Wisniewska Inga-Maria Frick Werner Streicher Lars Björck Johan Malmström Mats Wikström

Front Microbiol 2016 5;7:95. Epub 2016 Feb 5.

Protein Function and Interactions Group, Faculty of Health and Medical Sciences, The Novo Nordisk Foundation Center for Protein Research, University of Copenhagen Copenhagen, Denmark.

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February 2016

Interaction of RECQ4 and MCM10 is important for efficient DNA replication origin firing in human cells.

Authors:

Maciej Kliszczak Hana Sedlackova Ganesha P Pitchai Werner W Streicher Lumir Krejci Ian D Hickson

Oncotarget 2015 Dec;6(38):40464-79

Center for Chromosome Stability and Center for Healthy Aging, Department of Cellular and Molecular Medicine, University of Copenhagen, Copenhagen N, Denmark.

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December 2015

Liquid demixing of intrinsically disordered proteins is seeded by poly(ADP-ribose).

Authors:

Matthias Altmeyer Kai J Neelsen Federico Teloni Irina Pozdnyakova Stefania Pellegrino Merete Grøfte Maj-Britt Druedahl Rask Werner Streicher Stephanie Jungmichel Michael Lund Nielsen Jiri Lukas

Nat Commun 2015 Aug 19;6:8088. Epub 2015 Aug 19.

Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Blegdamsvej 3b, Copenhagen DK-2200, Denmark.

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August 2015

A de Novo-Designed Monomeric, Compact Three-Helix-Bundle Protein on a Carbohydrate Template.

Authors:

Leila Malik Jesper Nygaard Niels J Cristensen Charlotte S Madsen Heike I Rösner Birthe B Kragelund Rasmus Hoiberg-Nielsen Werner W Streicher Lise Arleth Peter W Thulstrup Knud J Jensen

Chembiochem 2015 Sep 14;16(13):1905-1918. Epub 2015 Aug 14.

Department of Chemistry, Faculty of Science, University of Copenhagen, Thorvaldsensvej 40, 1871 Frederiksberg (Denmark).

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September 2015

Structure of Dimeric and Tetrameric Complexes of the BAR Domain Protein PICK1 Determined by Small-Angle X-Ray Scattering.

Authors:

Morten L Karlsen Thor S Thorsen Niklaus Johner Ina Ammendrup-Johnsen Simon Erlendsson Xinsheng Tian Jens B Simonsen Rasmus Høiberg-Nielsen Nikolaj M Christensen George Khelashvili Werner Streicher Kaare Teilum Bente Vestergaard Harel Weinstein Ulrik Gether Lise Arleth Kenneth L Madsen

Structure 2015 Jul 11;23(7):1258-1270. Epub 2015 Jun 11.

Molecular Neuropharmacology and Genetics Laboratory, Lundbeck Foundation Center for Biomembranes in Nanomedicine, Department of Neuroscience and Pharmacology, Faculty of Health and Medical Sciences, The Panum Institute 18.6, University of Copenhagen, 2200 Copenhagen N, Denmark.

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July 2015

A multilaboratory comparison of calibration accuracy and the performance of external references in analytical ultracentrifugation.

Authors:

Huaying Zhao Rodolfo Ghirlando Carlos Alfonso Fumio Arisaka Ilan Attali David L Bain Marina M Bakhtina Donald F Becker Gregory J Bedwell Ahmet Bekdemir Tabot M D Besong Catherine Birck Chad A Brautigam William Brennerman Olwyn Byron Agnieszka Bzowska Jonathan B Chaires Catherine T Chaton Helmut Cölfen Keith D Connaghan Kimberly A Crowley Ute Curth Tina Daviter William L Dean Ana I Díez Christine Ebel Debra M Eckert Leslie E Eisele Edward Eisenstein Patrick England Carlos Escalante Jeffrey A Fagan Robert Fairman Ron M Finn Wolfgang Fischle José García de la Torre Jayesh Gor Henning Gustafsson Damien Hall Stephen E Harding José G Hernández Cifre Andrew B Herr Elizabeth E Howell Richard S Isaac Shu-Chuan Jao Davis Jose Soon-Jong Kim Bashkim Kokona Jack A Kornblatt Dalibor Kosek Elena Krayukhina Daniel Krzizike Eric A Kusznir Hyewon Kwon Adam Larson Thomas M Laue Aline Le Roy Andrew P Leech Hauke Lilie Karolin Luger Juan R Luque-Ortega Jia Ma Carrie A May Ernest L Maynard Anna Modrak-Wojcik Yee-Foong Mok Norbert Mücke Luitgard Nagel-Steger Geeta J Narlikar Masanori Noda Amanda Nourse Tomas Obsil Chad K Park Jin-Ku Park Peter D Pawelek Erby E Perdue Stephen J Perkins Matthew A Perugini Craig L Peterson Martin G Peverelli Grzegorz Piszczek Gali Prag Peter E Prevelige Bertrand D E Raynal Lenka Rezabkova Klaus Richter Alison E Ringel Rose Rosenberg Arthur J Rowe Arne C Rufer David J Scott Javier G Seravalli Alexandra S Solovyova Renjie Song David Staunton Caitlin Stoddard Katherine Stott Holger M Strauss Werner W Streicher John P Sumida Sarah G Swygert Roman H Szczepanowski Ingrid Tessmer Ronald T Toth Ashutosh Tripathy Susumu Uchiyama Stephan F W Uebel Satoru Unzai Anna Vitlin Gruber Peter H von Hippel Christine Wandrey Szu-Huan Wang Steven E Weitzel Beata Wielgus-Kutrowska Cynthia Wolberger Martin Wolff Edward Wright Yu-Sung Wu Jacinta M Wubben Peter Schuck

PLoS One 2015 21;10(5):e0126420. Epub 2015 May 21.

Dynamics of Macromolecular Assembly Section, Laboratory of Cellular Imaging and Macromolecular Biophysics, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, Maryland, 20892, United States of America.

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February 2016

Acetylation site specificities of lysine deacetylase inhibitors in human cells.

Authors:

Christian Schölz Brian T Weinert Sebastian A Wagner Petra Beli Yasuyuki Miyake Jun Qi Lars J Jensen Werner Streicher Anna R McCarthy Nicholas J Westwood Sonia Lain Jürgen Cox Patrick Matthias Matthias Mann James E Bradner Chunaram Choudhary

Nat Biotechnol 2015 Apr 9;33(4):415-23. Epub 2015 Mar 9.

Department of Proteomics, The Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.

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April 2015

Investigating the function of Fc-specific binding of IgM to Plasmodium falciparum erythrocyte membrane protein 1 mediating erythrocyte rosetting.

Authors:

Liz Stevenson Pie Huda Anine Jeppesen Erik Laursen J Alexandra Rowe Alister Craig Werner Streicher Lea Barfod Lars Hviid

Cell Microbiol 2015 Jun 28;17(6):819-31. Epub 2015 Jan 28.

Centre for Medical Parasitology, Department of International Health, Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.

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June 2015

Production of functional human insulin-like growth factor binding proteins (IGFBPs) using recombinant expression in HEK293 cells.

Authors:

Anne Sofie Molsted Wanscher Michael Williamson Tasja Wainani Ebersole Werner Streicher Mats Wikström Giuseppe Cazzamali

Protein Expr Purif 2015 Apr 11;108:97-105. Epub 2014 Nov 11.

Protein Production and Characterization Platform, Novo Nordisk Foundation Center for Protein Research, University of Copenhagen, Denmark.

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April 2015

Functional and structural properties of a novel protein and virulence factor (Protein sHIP) in Streptococcus pyogenes.

Authors:

Magdalena Wisniewska Lotta Happonen Fredrik Kahn Markku Varjosalo Lars Malmström George Rosenberger Christofer Karlsson Giuseppe Cazzamali Irina Pozdnyakova Inga-Maria Frick Lars Björck Werner Streicher Johan Malmström Mats Wikström

J Biol Chem 2014 Jun 13;289(26):18175-88. Epub 2014 May 13.

From the Novo Nordisk Foundation Center for Protein Research, University of Copenhagen, DK-2200 Copenhagen, Denmark,

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June 2014

A direct role of Mad1 in the spindle assembly checkpoint beyond Mad2 kinetochore recruitment.

Authors:

Thomas Kruse Marie Sofie Yoo Larsen Garry G Sedgwick Jón Otti Sigurdsson Werner Streicher Jesper V Olsen Jakob Nilsson

EMBO Rep 2014 Mar 29;15(3):282-90. Epub 2014 Jan 29.

The Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.

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March 2014

Small angle X-ray scattering studies of mitochondrial glutaminase C reveal extended flexible regions, and link oligomeric state with enzyme activity.

Authors:

Magda Møller Søren S Nielsen Sekar Ramachandran Yunxing Li Yuxing Li Giancarlo Tria Werner Streicher Maxim V Petoukhov Richard A Cerione Richard E Gillilan Bente Vestergaard

PLoS One 2013 30;8(9):e74783. Epub 2013 Sep 30.

Department of Drug Design and Pharmacology, University of Copenhagen, Copenhagen, Denmark.

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May 2014

Functional proteomics defines the molecular switch underlying FGF receptor trafficking and cellular outputs.

Authors:

Chiara Francavilla Kristoffer T G Rigbolt Kristina B Emdal Gianni Carraro Erik Vernet Dorte B Bekker-Jensen Werner Streicher Mats Wikström Michael Sundström Saverio Bellusci Ugo Cavallaro Blagoy Blagoev Jesper V Olsen

Mol Cell 2013 Sep 5;51(6):707-22. Epub 2013 Sep 5.

Department of Proteomics, NNF Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Blegdamsvej 3B, 2200 Copenhagen, Denmark.

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September 2013

PICH: a DNA translocase specially adapted for processing anaphase bridge DNA.

Authors:

Andreas Biebricher Seiki Hirano Jacqueline H Enzlin Nicola Wiechens Werner W Streicher Diana Huttner Lily H-C Wang Erich A Nigg Tom Owen-Hughes Ying Liu Erwin Peterman Gijs J L Wuite Ian D Hickson

Mol Cell 2013 Sep 22;51(5):691-701. Epub 2013 Aug 22.

Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, OX3 9DS, U. K.

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September 2013

RNF111/Arkadia is a SUMO-targeted ubiquitin ligase that facilitates the DNA damage response.

Authors:

Sara L Poulsen Rebecca K Hansen Sebastian A Wagner Loes van Cuijk Gijsbert J van Belle Werner Streicher Mats Wikström Chunaram Choudhary Adriaan B Houtsmuller Jurgen A Marteijn Simon Bekker-Jensen Niels Mailand

J Cell Biol 2013 Jun;201(6):797-807

Ubiquitin Signaling Group, Department of Disease Biology, The Novo Nordisk Foundation Center for Protein Research, University of Copenhagen, DK-2200 Copenhagen, Denmark.

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June 2013

Self-assembly of designed coiled coil peptides studied by small-angle X-ray scattering and analytical ultracentrifugation.

Authors:

Leila Malik Jesper Nygaard Niels J Christensen Werner W Streicher Peter W Thulstrup Lise Arleth Knud J Jensen

J Pept Sci 2013 May 17;19(5):283-92. Epub 2013 Mar 17.

University of Copenhagen, Thorvaldsensvej 40, DK-1871 Frederiksberg C, Denmark.

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May 2013

Direct binding between BubR1 and B56-PP2A phosphatase complexes regulate mitotic progression.

Authors:

Thomas Kruse Gang Zhang Marie Sofie Yoo Larsen Tiziana Lischetti Werner Streicher Tine Kragh Nielsen Sara Petersen Bjørn Jakob Nilsson

J Cell Sci 2013 Mar 23;126(Pt 5):1086-92. Epub 2013 Jan 23.

The Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Blegdamsvej 3b, 2200 Copenhagen, Denmark.

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March 2013

Thermodynamic and kinetic analysis of peptides derived from CapZ, NDR, p53, HDM2, and HDM4 binding to human S100B.

Authors:

Lucas N Wafer Werner W Streicher Scott A McCallum George I Makhatadze

Biochemistry 2012 Sep 29;51(36):7189-201. Epub 2012 Aug 29.

Center for Biotechnology and Interdisciplinary Studies and Department of Biology, Rensselaer Polytechnic Institute, 110 8th Street, Troy, NY 12180, USA.

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September 2012