Prof. Dr. Werner Muller, Dr. rer. nat - University of Manchester - Inagural Bill Ford Chair of cellular Immunology

Prof. Dr. Werner Muller

Dr. rer. nat

University of Manchester

Inagural Bill Ford Chair of cellular Immunology

Manchester | United Kingdom

Main Specialties: Allergy & Immunology

Additional Specialties: Immunology

ORCID logohttps://orcid.org/0000-0002-1297-9725

Prof. Dr. Werner Muller, Dr. rer. nat - University of Manchester - Inagural Bill Ford Chair of cellular Immunology

Prof. Dr. Werner Muller

Dr. rer. nat

Introduction

Primary Affiliation: University of Manchester - Manchester , United Kingdom

Specialties:

Additional Specialties:

Education

Jan 1987
University of Cologne
Dr. rer. nat.
Institute for Genetics
Jan 1981
University of Cologne
Diplom-Biologe
Institute of Genetics

Experience

Aug 2018 - Aug 2018
Miltenyi Biotec GmbH
Research Manager
Research and Development
Aug 2016 - Jul 2018
University of Manchester
Inaugural Bill Ford Chair of Cellular Immunology
Faculty of Biology, Medicine and Health
Oct 2000 - Oct 2008
Helmholtz-Zentrum für Infektionsforschung
Department Head
Department of experimental Immunology
Jun 1987 - Oct 2000
University of Cologne

Institute of Genetics

Publications

117Publications

2686Reads

306Profile Views

1221PubMed Central Citations

Permeability analyses and three dimensional imaging of interferon gamma-induced barrier disintegration in intestinal organoids.

Stem Cell Res 2019 03 7;35:101383. Epub 2019 Feb 7.

Division of Molecular and Experimental Surgery, Department of Surgery, Friedrich-Alexander-Universität (FAU) Erlangen-Nürnberg and Universitätsklinikum Erlangen, Translational Research Center, 91054 Erlangen, Germany; Optical Imaging Centre Erlangen (OICE), Friedrich-Alexander-Universität (FAU) Erlangen-Nürnberg, 91052 Erlangen, Germany.

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http://dx.doi.org/10.1016/j.scr.2019.101383DOI Listing
March 2019
4 Reads
3.693 Impact Factor

IL-10 signaling in dendritic cells is required for tolerance induction in a murine model of allergic airway inflammation.

Eur J Immunol 2019 Feb 3;49(2):302-312. Epub 2019 Jan 3.

Allergy Research Group, Department of Dermatology, Medical Center, University of Freiburg, Freiburg, Germany.

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http://dx.doi.org/10.1002/eji.201847883DOI Listing
February 2019
44 Reads
4.034 Impact Factor

Innate Sensing through Mesenchymal TLR4/MyD88 Signals Promotes Spontaneous Intestinal Tumorigenesis.

Cell Rep 2019 01;26(3):536-545.e4

Biomedical Sciences Research Centre (BSRC) "Alexander Fleming," Vari 16672, Greece; Department of Physiology, Medical School, National and Kapodistrian University of Athens, Athens 11527, Greece. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S22111247183201
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http://dx.doi.org/10.1016/j.celrep.2018.12.072DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6334226PMC
January 2019
23 Reads
7.207 Impact Factor

Evaluating the IgMi mouse as a novel tool to study B-cell biology.

Eur J Immunol 2018 12 26;48(12):2068-2071. Epub 2018 Oct 26.

Lydia Becker Institute of Immunology and Inflammation, Faculty of Biology, Medicine and Health, Manchester Academic Health Science centre, The University of Manchester, Manchester, United Kingdom of Great Britain and Northern Ireland.

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http://doi.wiley.com/10.1002/eji.201847735
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http://dx.doi.org/10.1002/eji.201847735DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6750126PMC
December 2018
287 Reads
4.034 Impact Factor

Guidelines for the use of flow cytometry and cell sorting in immunological studies.

Authors:
Andrea Cossarizza Hyun-Dong Chang Andreas Radbruch Mübeccel Akdis Immanuel Andrä Francesco Annunziato Petra Bacher Vincenzo Barnaba Luca Battistini Wolfgang M Bauer Sabine Baumgart Burkhard Becher Wolfgang Beisker Claudia Berek Alfonso Blanco Giovanna Borsellino Philip E Boulais Ryan R Brinkman Martin Büscher Dirk H Busch Timothy P Bushnell Xuetao Cao Andrea Cavani Pratip K Chattopadhyay Qingyu Cheng Sue Chow Mario Clerici Anne Cooke Antonio Cosma Lorenzo Cosmi Ana Cumano Van Duc Dang Derek Davies Sara De Biasi Genny Del Zotto Silvia Della Bella Paolo Dellabona Günnur Deniz Mark Dessing Andreas Diefenbach James Di Santo Francesco Dieli Andreas Dolf Vera S Donnenberg Thomas Dörner Götz R A Ehrhardt Elmar Endl Pablo Engel Britta Engelhardt Charlotte Esser Bart Everts Anita Dreher Christine S Falk Todd A Fehniger Andrew Filby Simon Fillatreau Marie Follo Irmgard Förster John Foster Gemma A Foulds Paul S Frenette David Galbraith Natalio Garbi Maria Dolores García-Godoy Jens Geginat Kamran Ghoreschi Lara Gibellini Christoph Goettlinger Carl S Goodyear Andrea Gori Jane Grogan Mor Gross Andreas Grützkau Daryl Grummitt Jonas Hahn Quirin Hammer Anja E Hauser David L Haviland David Hedley Guadalupe Herrera Martin Herrmann Falk Hiepe Tristan Holland Pleun Hombrink Jessica P Houston Bimba F Hoyer Bo Huang Christopher A Hunter Anna Iannone Hans-Martin Jäck Beatriz Jávega Stipan Jonjic Kerstin Juelke Steffen Jung Toralf Kaiser Tomas Kalina Baerbel Keller Srijit Khan Deborah Kienhöfer Thomas Kroneis Désirée Kunkel Christian Kurts Pia Kvistborg Joanne Lannigan Olivier Lantz Anis Larbi Salome LeibundGut-Landmann Michael D Leipold Megan K Levings Virginia Litwin Yanling Liu Michael Lohoff Giovanna Lombardi Lilly Lopez Amy Lovett-Racke Erik Lubberts Burkhard Ludewig Enrico Lugli Holden T Maecker Glòria Martrus Giuseppe Matarese Christian Maueröder Mairi McGrath Iain McInnes Henrik E Mei Fritz Melchers Susanne Melzer Dirk Mielenz Kingston Mills David Mirrer Jenny Mjösberg Jonni Moore Barry Moran Alessandro Moretta Lorenzo Moretta Tim R Mosmann Susann Müller Werner Müller Christian Münz Gabriele Multhoff Luis Enrique Munoz Kenneth M Murphy Toshinori Nakayama Milena Nasi Christine Neudörfl John Nolan Sussan Nourshargh José-Enrique O'Connor Wenjun Ouyang Annette Oxenius Raghav Palankar Isabel Panse Pärt Peterson Christian Peth Jordi Petriz Daisy Philips Winfried Pickl Silvia Piconese Marcello Pinti A Graham Pockley Malgorzata Justyna Podolska Carlo Pucillo Sally A Quataert Timothy R D J Radstake Bartek Rajwa Jonathan A Rebhahn Diether Recktenwald Ester B M Remmerswaal Katy Rezvani Laura G Rico J Paul Robinson Chiara Romagnani Anna Rubartelli Beate Ruckert Jürgen Ruland Shimon Sakaguchi Francisco Sala-de-Oyanguren Yvonne Samstag Sharon Sanderson Birgit Sawitzki Alexander Scheffold Matthias Schiemann Frank Schildberg Esther Schimisky Stephan A Schmid Steffen Schmitt Kilian Schober Thomas Schüler Axel Ronald Schulz Ton Schumacher Cristiano Scotta T Vincent Shankey Anat Shemer Anna-Katharina Simon Josef Spidlen Alan M Stall Regina Stark Christina Stehle Merle Stein Tobit Steinmetz Hannes Stockinger Yousuke Takahama Attila Tarnok ZhiGang Tian Gergely Toldi Julia Tornack Elisabetta Traggiai Joe Trotter Henning Ulrich Marlous van der Braber René A W van Lier Marc Veldhoen Salvador Vento-Asturias Paulo Vieira David Voehringer Hans-Dieter Volk Konrad von Volkmann Ari Waisman Rachael Walker Michael D Ward Klaus Warnatz Sarah Warth James V Watson Carsten Watzl Leonie Wegener Annika Wiedemann Jürgen Wienands Gerald Willimsky James Wing Peter Wurst Liping Yu Alice Yue Qianjun Zhang Yi Zhao Susanne Ziegler Jakob Zimmermann

Eur J Immunol 2017 10;47(10):1584-1797

Maurice Müller Laboratories (DKF), Universitätsklinik für Viszerale Chirurgie und Medizin Inselspital, University of Bern, Murtenstrasse, Bern.

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http://doi.wiley.com/10.1002/eji.201646632
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http://dx.doi.org/10.1002/eji.201646632DOI Listing
October 2017
131 Reads
4.034 Impact Factor

TGF-β inhibitor Smad7 regulates dendritic cell-induced autoimmunity.

Proc Natl Acad Sci U S A 2017 02 6;114(8):E1480-E1489. Epub 2017 Feb 6.

Institute for Molecular Medicine, University Medical Center of the Johannes Gutenberg University Mainz, 55131 Mainz, Germany;

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http://dx.doi.org/10.1073/pnas.1615065114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5338403PMC
February 2017
57 Reads
9.809 Impact Factor

P2X7 receptor-dependent tuning of gut epithelial responses to infection.

Immunol Cell Biol 2017 02 25;95(2):178-188. Epub 2016 Aug 25.

Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, UK.

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http://dx.doi.org/10.1038/icb.2016.75DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5181772PMC
February 2017
8 Reads
4.150 Impact Factor

Constitutive Kit activity triggers B-cell acute lymphoblastic leukemia-like disease in mice.

Exp Hematol 2017 Jan 21;45:45-55.e6. Epub 2016 Sep 21.

Institute for Immunology, Medical Faculty Carl Gustav Carus, TU Dresden, Dresden, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.exphem.2016.09.005DOI Listing
January 2017
5 Reads
2.480 Impact Factor

IL-1 signaling is critical for expansion but not generation of autoreactive GM-CSF+ Th17 cells.

EMBO J 2017 01 8;36(1):102-115. Epub 2016 Nov 8.

Institute for Molecular Medicine, University Medical Center of the Johannes Gutenberg-University Mainz, Mainz, Germany

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http://dx.doi.org/10.15252/embj.201694615DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5210124PMC
January 2017
40 Reads
10.434 Impact Factor

Loss of Trex1 in Dendritic Cells Is Sufficient To Trigger Systemic Autoimmunity.

J Immunol 2016 09 10;197(6):2157-66. Epub 2016 Aug 10.

Institute for Immunology, Faculty of Medicine Carl Gustav Carus, University of Technology, 01307 Dresden, Germany;

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http://dx.doi.org/10.4049/jimmunol.1600722DOI Listing
September 2016
38 Reads
1 Citation
4.922 Impact Factor

Deleting myeloid IL-10 receptor signalling attenuates atherosclerosis in LDLR-/- mice by altering intestinal cholesterol fluxes.

Thromb Haemost 2016 08 30;116(3):565-77. Epub 2016 Jun 30.

Prof. M. P. J. de Winther, PhD, Experimental Vascular Biology, Medical Biochemistry, Academic Medical Center, University of Amsterdam, Meibergdreef 15, 1105 AZ Amsterdam, The Netherlands, Tel.: +31 20 5666762, E-mail:

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http://dx.doi.org/10.1160/TH16-01-0043DOI Listing
August 2016
44 Reads
4.984 Impact Factor

T cell derived IL-10 is dispensable for tolerance induction in a murine model of allergic airway inflammation.

Eur J Immunol 2016 08 11;46(8):2018-27. Epub 2016 Jul 11.

Allergy Research Group, Department of Dermatology, Medical Center-University of Freiburg, Freiburg, Germany.

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http://dx.doi.org/10.1002/eji.201646319DOI Listing
August 2016
65 Reads
4.034 Impact Factor

Myeloid interferon-γ receptor deficiency does not affect atherosclerosis in LDLR(-/-) mice.

Atherosclerosis 2016 Mar 19;246:325-33. Epub 2016 Jan 19.

Experimental Vascular Biology, Department of Medical Biochemistry, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.atherosclerosis.2016.01.026DOI Listing
March 2016
10 Reads
3.994 Impact Factor

Colonic gene silencing using siRNA-loaded calcium phosphate/PLGA nanoparticles ameliorates intestinal inflammation in vivo.

J Control Release 2016 Jan 14;222:86-96. Epub 2015 Dec 14.

Infection Immunology, Institute of Medical Microbiology, University Hospital Essen, University Duisburg-Essen, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.jconrel.2015.12.021DOI Listing
January 2016
15 Reads
3 Citations
7.705 Impact Factor

Malaria parasite infection compromises control of concurrent systemic non-typhoidal Salmonella infection via IL-10-mediated alteration of myeloid cell function.

PLoS Pathog 2014 May 1;10(5):e1004049. Epub 2014 May 1.

Department of Microbiology & Immunology, School of Medicine, University of California at Davis, Davis, California, United States of America.

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http://dx.doi.org/10.1371/journal.ppat.1004049DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4006898PMC
May 2014
17 Reads
27 Citations

Macrophage-restricted interleukin-10 receptor deficiency, but not IL-10 deficiency, causes severe spontaneous colitis.

Immunity 2014 May 1;40(5):720-33. Epub 2014 May 1.

Department of Immunology, Weizmann Institute of Science, Rehovot 76100, Israel. Electronic address:

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http://dx.doi.org/10.1016/j.immuni.2014.03.012DOI Listing
May 2014
31 Reads
92 Citations
21.561 Impact Factor

Protective mucosal immunity mediated by epithelial CD1d and IL-10.

Nature 2014 May 6;509(7501):497-502. Epub 2014 Apr 6.

1] Division of Gastroenterology, Hepatology, and Endoscopy, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA [2].

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http://dx.doi.org/10.1038/nature13150DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4132962PMC
May 2014
37 Reads
50 Citations
42.351 Impact Factor

IFN-γ-mediated induction of an apical IL-10 receptor on polarized intestinal epithelia.

J Immunol 2014 Feb 23;192(3):1267-76. Epub 2013 Dec 23.

Department of Anesthesiology and Perioperative Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO 80045;

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http://dx.doi.org/10.4049/jimmunol.1301757DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4042245PMC
February 2014
22 Reads
17 Citations
4.922 Impact Factor

CD4+ T cell-derived IL-10 promotes Brucella abortus persistence via modulation of macrophage function.

PLoS Pathog 2013 20;9(6):e1003454. Epub 2013 Jun 20.

Department of Medical Microbiology and Immunology, School of Medicine, University of California at Davis, Davis, California, United States of America.

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http://dx.doi.org/10.1371/journal.ppat.1003454DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3688575PMC
January 2014
9 Reads
18 Citations

T cell-derived IL-10 determines leishmaniasis disease outcome and is suppressed by a dendritic cell based vaccine.

PLoS Pathog 2013 27;9(6):e1003476. Epub 2013 Jun 27.

Institute for Molecular Infection Biology, University of Würzburg, Würzburg, Germany.

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http://dx.doi.org/10.1371/journal.ppat.1003476DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3694851PMC
January 2014
22 Reads
18 Citations

Neuroprotective intervention by interferon-γ blockade prevents CD8+ T cell-mediated dendrite and synapse loss.

J Exp Med 2013 Sep 2;210(10):2087-103. Epub 2013 Sep 2.

Department of Pathology and Immunology and 2 World Health Organization Collaborating Centre for Vaccine Immunology, University of Geneva, 1211 Geneva, Switzerland.

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http://dx.doi.org/10.1084/jem.20122143DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3782053PMC
September 2013
28 Reads
12 Citations
12.520 Impact Factor

Monocyte-derived dendritic cells perform hemophagocytosis to fine-tune excessive immune responses.

Immunity 2013 Sep 12;39(3):584-98. Epub 2013 Sep 12.

Department of Hematology, Nephrology and Rheumatology, Akita University Graduate School of Medicine, Akita 010-8543, Japan.

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http://dx.doi.org/10.1016/j.immuni.2013.06.019DOI Listing
September 2013
32 Reads
24 Citations
21.561 Impact Factor

T-cell-derived, but not B-cell-derived, IL-10 suppresses antigen-specific T-cell responses in Litomosoides sigmodontis-infected mice.

Eur J Immunol 2013 Jul 8;43(7):1799-805. Epub 2013 May 8.

Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany.

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http://dx.doi.org/10.1002/eji.201242929DOI Listing
July 2013
19 Reads
7 Citations
4.034 Impact Factor

IL-10 acts as a developmental switch guiding monocyte differentiation to macrophages during a murine peritoneal infection.

J Immunol 2012 Sep 6;189(6):3112-20. Epub 2012 Aug 6.

Department of Immunology, University of Greifswald, 17487 Greifswald, Germany.

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http://dx.doi.org/10.4049/jimmunol.1200360DOI Listing
September 2012
13 Reads
14 Citations
4.922 Impact Factor

β7 integrin controls immunogenic and tolerogenic mucosal B cell responses.

Clin Immunol 2012 Aug 24;144(2):87-97. Epub 2012 May 24.

Department of Pediatrics, Medical Faculty, RWTH Aachen University, Aachen D-52074, Germany.

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http://dx.doi.org/10.1016/j.clim.2012.05.008DOI Listing
August 2012
3 Reads
3 Citations
3.672 Impact Factor

Neuronal gp130 expression is crucial to prevent neuronal loss, hyperinflammation, and lethal course of murine Toxoplasma encephalitis.

Am J Pathol 2012 Jul 26;181(1):163-73. Epub 2012 May 26.

Institute of Medical Microbiology, Otto-von-Guericke University, Magdeburg, Magdeburg, Germany.

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http://dx.doi.org/10.1016/j.ajpath.2012.03.029DOI Listing
July 2012
8 Reads
8 Citations
4.591 Impact Factor

Strong impact of CD4+ Foxp3+ regulatory T cells and limited effect of T cell-derived IL-10 on pathogen clearance during Plasmodium yoelii infection.

J Immunol 2012 Jun 27;188(11):5467-77. Epub 2012 Apr 27.

Institute of Medical Microbiology, University Hospital Essen, University Duisburg-Essen, 45122 Essen, Germany.

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http://dx.doi.org/10.4049/jimmunol.1102223DOI Listing
June 2012
20 Reads
15 Citations
4.922 Impact Factor

Induction of regulatory T cells by a murine β-defensin.

J Immunol 2012 Jan 14;188(2):735-43. Epub 2011 Dec 14.

Department of Dermatology and Allergology, University of Kiel, 24105 Kiel, Germany.

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http://dx.doi.org/10.4049/jimmunol.1100452DOI Listing
January 2012
8 Reads
9 Citations
4.922 Impact Factor

B cell-derived IL-10 does not regulate spontaneous systemic autoimmunity in MRL.Fas(lpr) mice.

J Immunol 2012 Jan 9;188(2):678-85. Epub 2011 Dec 9.

Department of Laboratory Medicine, Yale University School of Medicine, New Haven, CT 06519, USA.

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http://dx.doi.org/10.4049/jimmunol.1102456DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3253138PMC
January 2012
6 Reads
24 Citations
4.922 Impact Factor

Commensal gut flora reduces susceptibility to experimentally induced colitis via T-cell-derived interleukin-10.

Inflamm Bowel Dis 2011 Oct 22;17(10):2038-46. Epub 2010 Dec 22.

Experimental Immunology, Helmholtz Centre for Infection Research, Braunschweig, Germany.

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http://dx.doi.org/10.1002/ibd.21587DOI Listing
October 2011
15 Reads
4.464 Impact Factor

gp130 on macrophages/granulocytes modulates inflammation during experimental tuberculosis.

Eur J Cell Biol 2011 Jun-Jul;90(6-7):505-14. Epub 2010 Dec 8.

Infection Immunology, Research Center Borstel, Borstel, Germany.

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http://dx.doi.org/10.1016/j.ejcb.2010.10.010DOI Listing
September 2011
8 Reads
3.825 Impact Factor

Autocrine regulation of pulmonary inflammation by effector T-cell derived IL-10 during infection with respiratory syncytial virus.

PLoS Pathog 2011 Aug 4;7(8):e1002173. Epub 2011 Aug 4.

The Beirne B. Carter Center for Immunology Research, The University of Virginia, Charlottesville, Virginia, United States of America.

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http://dx.doi.org/10.1371/journal.ppat.1002173DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3150291PMC
August 2011
6 Reads
32 Citations

Pro-B cells sense productive immunoglobulin heavy chain rearrangement irrespective of polypeptide production.

Proc Natl Acad Sci U S A 2011 Jun 13;108(26):10644-9. Epub 2011 Jun 13.

Division of Molecular Immunology, Department of Internal Medicine III, Nikolaus-Fiebiger-Center of Molecular Medicine, Friedrich-Alexander-University Erlangen-Nürnberg, D-91054 Erlangen, Germany.

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http://dx.doi.org/10.1073/pnas.1019224108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3127927PMC
June 2011
9 Reads
13 Citations
9.810 Impact Factor

Mast cells are key promoters of contact allergy that mediate the adjuvant effects of haptens.

Immunity 2011 Jun;34(6):973-84

Institute for Immunology, University of Technology Dresden, Medical Faculty Carl-Gustav Carus, 01307 Dresden, Germany.

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http://dx.doi.org/10.1016/j.immuni.2011.03.028DOI Listing
June 2011
37 Reads
91 Citations
21.561 Impact Factor

Interleukin-10 signaling in regulatory T cells is required for suppression of Th17 cell-mediated inflammation.

Immunity 2011 Apr;34(4):566-78

Howard Hughes Medical Institute and Immunology Program, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA.

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http://dx.doi.org/10.1016/j.immuni.2011.03.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3088485PMC
April 2011
27 Reads
200 Citations
21.561 Impact Factor

Intestinal tolerance requires gut homing and expansion of FoxP3+ regulatory T cells in the lamina propria.

Immunity 2011 Feb 17;34(2):237-46. Epub 2011 Feb 17.

Institute of Immunology, Hannover Medical School, Hannover, Germany.

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http://dx.doi.org/10.1016/j.immuni.2011.01.016DOI Listing
February 2011
9 Reads
202 Citations
21.561 Impact Factor

TLR-2-activated B cells suppress Helicobacter-induced preneoplastic gastric immunopathology by inducing T regulatory-1 cells.

J Immunol 2011 Jan 13;186(2):878-90. Epub 2010 Dec 13.

Institute of Molecular Cancer Research, University of Zürich, Zürich 8057, Switzerland.

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http://dx.doi.org/10.4049/jimmunol.1002269DOI Listing
January 2011
1 Read
4.922 Impact Factor

Monocytes/macrophages and/or neutrophils are the target of IL-10 in the LPS endotoxemia model.

Eur J Immunol 2010 Feb;40(2):443-8

Department of Experimental Immunology, Helmholtz-Centre for Infection Research, Braunschweig, Germany.

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http://dx.doi.org/10.1002/eji.200939592DOI Listing
February 2010
7 Reads
4.034 Impact Factor

Preconditioning-induced protection of photoreceptors requires activation of the signal-transducing receptor gp130 in photoreceptors.

Proc Natl Acad Sci U S A 2009 Dec 30;106(50):21389-94. Epub 2009 Nov 30.

Department of Cell Biology, Oklahoma Center for Neuroscience, University of Oklahoma Health Sciences Center, Oklahoma City, OK73104, USA.

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http://dx.doi.org/10.1073/pnas.0906156106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2785722PMC
December 2009
3 Reads
9.809 Impact Factor

Hepatocyte gp130 deficiency reduces vascular remodeling after carotid artery ligation.

Hypertension 2009 Nov 5;54(5):1035-42. Epub 2009 Oct 5.

Department of Cardiology and Angiology, Hannover Medical School, Hannover, Germany.

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http://dx.doi.org/10.1161/HYPERTENSIONAHA.109.136002DOI Listing
November 2009
16 Reads
6.480 Impact Factor

Charles River altered Schaedler flora (CRASF) remained stable for four years in a mouse colony housed in individually ventilated cages.

Lab Anim 2009 Oct 17;43(4):362-70. Epub 2009 Jun 17.

Department of Genome Analysis, Helmholtz Centre for Infection Research, Inhoffenstrasse 7, 38124 Braunschweig, Germany.

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http://dx.doi.org/10.1258/la.2009.0080075DOI Listing
October 2009
29 Reads
1.120 Impact Factor

Mucosal addressin cell-adhesion molecule-1 controls plasma-cell migration and function in the small intestine of mice.

Gastroenterology 2009 Sep 18;137(3):924-33. Epub 2009 May 18.

Department of Pediatrics, Medical Faculty, RWTH Aachen University, Germany.

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http://dx.doi.org/10.1053/j.gastro.2009.05.039DOI Listing
September 2009
22 Reads
16.716 Impact Factor

T-cell-specific deletion of gp130 renders the highly susceptible IL-10-deficient mouse resistant to intestinal nematode infection.

Eur J Immunol 2009 Aug;39(8):2173-83

Department of Experimental Immunology, Helmholtz Centre for Infection Research, Braunschweig, Germany.

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http://doi.wiley.com/10.1002/eji.200838710
Publisher Site
http://dx.doi.org/10.1002/eji.200838710DOI Listing
August 2009
7 Reads
4.034 Impact Factor

Functional knockdown of VCAM-1 at the posttranslational level with ER retained antibodies.

J Immunol Methods 2009 Feb 25;341(1-2):30-40. Epub 2008 Nov 25.

Technische Universität Braunschweig, Spielmannstr. 7, 38106 Braunschweig, Germany.

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http://dx.doi.org/10.1016/j.jim.2008.10.012DOI Listing
February 2009
2.005 Impact Factor

IL-20 receptor 2 signaling down-regulates antigen-specific T cell responses.

J Immunol 2009 Jan;182(2):802-10

University Medical Center, Center of Internal Medicine, Department of Internal Medicine I, Ulm, Germany.

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http://dx.doi.org/10.4049/jimmunol.182.2.802DOI Listing
January 2009
5 Reads
4.922 Impact Factor

Excessive CpG 1668 stimulation triggers IL-10 production by cDC that inhibits IFN-alpha responses by pDC.

Eur J Immunol 2008 Nov;38(11):3127-37

Division of Immunology, Paul-Ehrlich-Institut, Langen, Germany.

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http://dx.doi.org/10.1002/eji.200838184DOI Listing
November 2008
7 Reads
4.034 Impact Factor

Tolerance without clonal expansion: self-antigen-expressing B cells program self-reactive T cells for future deletion.

J Immunol 2008 Oct;181(8):5748-59

I. Medical Department, Johannes Gutenberg-University Mainz, Obere Zahlbacher Str. 63, Mainz, Germany.

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http://dx.doi.org/10.4049/jimmunol.181.8.5748DOI Listing
October 2008
11 Reads
4.922 Impact Factor

Astrocyte gp130 expression is critical for the control of Toxoplasma encephalitis.

J Immunol 2008 Aug;181(4):2683-93

Institut für Medizinische Mikrobiologie, Otto-von-Guericke-Universität, Magdeburg, Germany.

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http://dx.doi.org/10.4049/jimmunol.181.4.2683DOI Listing
August 2008
4 Reads
4.922 Impact Factor

Conditional gp130 deficient mouse mutants.

Semin Cell Dev Biol 2008 Aug 17;19(4):379-84. Epub 2008 Jul 17.

Helmholtz-Center for Infection Research, Braunschweig, Germany.

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http://dx.doi.org/10.1016/j.semcdb.2008.07.001DOI Listing
August 2008
4 Reads
6.265 Impact Factor

Molecular mimicry between neurons and an intracerebral pathogen induces a CD8 T cell-mediated autoimmune disease.

J Immunol 2008 Jun;180(12):8421-33

Abteilung für Neuropathologie, Universitätsklinikum Köln, Köln, Germany.

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http://dx.doi.org/10.4049/jimmunol.180.12.8421DOI Listing
June 2008
3 Reads
4.922 Impact Factor

Role of beta7 integrin and the chemokine/chemokine receptor pair CCL25/CCR9 in modeled TNF-dependent Crohn's disease.

Gastroenterology 2008 Jun 5;134(7):2025-35. Epub 2008 Mar 5.

Institute of Immunology, Biomedical Sciences Research Center Alexander Fleming, Vari, Greece.

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http://dx.doi.org/10.1053/j.gastro.2008.02.085DOI Listing
June 2008
14 Reads
16.716 Impact Factor

GP130-STAT3 regulates epithelial cell migration and is required for repair of the bronchiolar epithelium.

Am J Pathol 2008 Jun 8;172(6):1542-54. Epub 2008 May 8.

Section of Neonatology, Perinatal and Pulmonary Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229-3039, USA.

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http://dx.doi.org/10.2353/ajpath.2008.071052DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2408415PMC
June 2008
19 Reads
4.591 Impact Factor

Mast cell-specific Cre/loxP-mediated recombination in vivo.

Transgenic Res 2008 Apr 31;17(2):307-15. Epub 2007 Oct 31.

Department of Dermatology, University of Cologne, Kerpener Str. 62, 50937, Cologne, Germany.

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http://dx.doi.org/10.1007/s11248-007-9153-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2268725PMC
April 2008
11 Reads
2.322 Impact Factor

Regulatory T cell-derived interleukin-10 limits inflammation at environmental interfaces.

Immunity 2008 Apr;28(4):546-58

Department of Immunology, University of Washington School of Medicine, Seattle, WA 98195, USA.

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http://dx.doi.org/10.1016/j.immuni.2008.02.017DOI Listing
April 2008
70 Reads
21.561 Impact Factor

Susceptibility of four inbred mouse strains to a low-pathogenic isolate of Yersinia enterocolitica.

Mamm Genome 2008 Apr 5;19(4):279-91. Epub 2008 Apr 5.

Department of Experimental Immunology, Helmholtz Centre for Infection Research, Inhoffenstrasse 7, 38124 Braunschweig, Germany.

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http://dx.doi.org/10.1007/s00335-008-9105-1DOI Listing
April 2008
1 Read
3.068 Impact Factor

Differential molecular and anatomical basis for B cell migration into the peritoneal cavity and omental milky spots.

J Immunol 2008 Feb;180(4):2196-203

Institute of Immunology, Hannover Medical School, Carl-Neuberg-Strasse 1, Hannover, Germany.

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http://dx.doi.org/10.4049/jimmunol.180.4.2196DOI Listing
February 2008
2 Reads
4.922 Impact Factor

LMP1 signaling can replace CD40 signaling in B cells in vivo and has unique features of inducing class-switch recombination to IgG1.

Blood 2008 Feb 15;111(3):1448-55. Epub 2007 Nov 15.

Institute of Clinical Molecular Biology and Tumor Genetics, GSF-National Research Center for Environment and Health, Munich, Germany.

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http://dx.doi.org/10.1182/blood-2007-10-117655DOI Listing
February 2008
6 Reads
10.452 Impact Factor

Sphingosine-1 phosphate signaling regulates positioning of dendritic cells within the spleen.

J Immunol 2007 Nov;179(9):5855-63

Institute of Immunology, Hannover Medical School, Hannover, Germany.

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http://dx.doi.org/10.4049/jimmunol.179.9.5855DOI Listing
November 2007
1 Read
4.922 Impact Factor

Serum response factor contributes selectively to lymphocyte development.

J Biol Chem 2007 Aug 25;282(33):24320-8. Epub 2007 Jun 25.

Department of Experimental Immunology, Helmholtz Centre for Infection Research, 38124 Braunschweig, Germany.

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http://dx.doi.org/10.1074/jbc.M703119200DOI Listing
August 2007
2 Reads
4.573 Impact Factor

Dissecting the cytokine network.

Authors:
Werner Müller

Cell Immunol 2006 Dec 11;244(2):162-4. Epub 2007 Apr 11.

University of Manchester, Michael Smith Building, Oxford Road, Manchester, M13 9PT, UK.

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http://dx.doi.org/10.1016/j.cellimm.2007.01.008DOI Listing
December 2006
1.924 Impact Factor

Interleukin-10 derived from macrophages and/or neutrophils regulates the inflammatory response to LPS but not the response to CpG DNA.

Eur J Immunol 2006 Dec;36(12):3248-55

Department of Dermatology, University of Cologne, Cologne, Germany.

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http://dx.doi.org/10.1002/eji.200636012DOI Listing
December 2006
32 Reads
4.034 Impact Factor

VH replacement rescues progenitor B cells with two nonproductive VDJ alleles.

J Immunol 2006 Nov;177(10):7007-14

Division of Molecular Immunology, Department of Internal Medicine III, Nikolaus-Fiebiger-Center of Molecular Medicine, Friedrich-Alexander-University Erlangen-Nürnberg, Erlangen, Germany.

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http://dx.doi.org/10.4049/jimmunol.177.10.7007DOI Listing
November 2006
2 Reads
4.922 Impact Factor

Adult murine hematopoiesis can proceed without beta1 and beta7 integrins.

Blood 2006 Sep 30;108(6):1857-64. Epub 2006 May 30.

Max Planck Institute of Biochemistry, Department of Molecular Medicine, Am Klopferspitz 18, 82152 Martinsried, Germany.

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http://dx.doi.org/10.1182/blood-2005-10-007658DOI Listing
September 2006
3 Reads
10.452 Impact Factor

Nine fluorescence parameter analysis on a four-color fluorescence activated flow cytometer.

Cytometry A 2006 Mar;69(3):124-6

German Research Centre for Biotechnology, Department of Experimental Immunology, Mascheroder Weg 1, D-38124 Braunschweig.

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http://dx.doi.org/10.1002/cyto.a.20221DOI Listing
March 2006
1 Read
2.928 Impact Factor

Enhanced FTY720-mediated lymphocyte homing requires G alpha i signaling and depends on beta 2 and beta 7 integrin.

J Immunol 2006 Feb;176(3):1474-80

Institute of Immunology, Hannover Medical School, Hannover, Germany.

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http://dx.doi.org/10.4049/jimmunol.176.3.1474DOI Listing
February 2006
8 Reads
4.922 Impact Factor

Virus free, cell-based assay for the quantification of murine type I interferons.

J Immunol Methods 2005 Nov 21;306(1-2):169-75. Epub 2005 Sep 21.

Experimental Immunology, German Research Centre for Biotechnology (GBF), Mascheroder Weg 1, D-38124 Braunschweig, Germany.

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http://dx.doi.org/10.1016/j.jim.2005.08.005DOI Listing
November 2005
9 Reads
2.005 Impact Factor

Interleukin 6/gp130-dependent pathways are protective during chronic liver diseases.

Hepatology 2003 Jul;38(1):218-29

Department of Gastroenterology, Hepatology and Endocrinology, Medizinische Hochschule Hannover, Hannover, Germany.

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http://dx.doi.org/10.1053/jhep.2003.50268DOI Listing
July 2003
11.055 Impact Factor

IL-15 is an essential mediator of peripheral NK-cell homeostasis.

Blood 2003 Jun 13;101(12):4887-93. Epub 2003 Feb 13.

Unité des Cytokines et Développement Lymphoïde, Institut Pasteur, Paris, France.

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http://dx.doi.org/10.1182/blood-2002-11-3392DOI Listing
June 2003
28 Reads
10.452 Impact Factor

Mice with neonatally induced inactivation of the vascular cell adhesion molecule-1 fail to control the parasite in Toxoplasma encephalitis.

Eur J Immunol 2003 May;33(5):1418-28

Abteilung für Neuropathologie, Universität zu Köln, Cologne, Germany.

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http://dx.doi.org/10.1002/eji.200322826DOI Listing
May 2003
2 Reads
4.034 Impact Factor

Interleukin-6/glycoprotein 130-dependent pathways are protective during liver regeneration.

J Biol Chem 2003 Mar 30;278(13):11281-8. Epub 2002 Dec 30.

Department of Gastroenterology, Hepatology, and Endocrinology, Medizinische Hochschule Hannover, 30625 Hannover, Germany.

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http://dx.doi.org/10.1074/jbc.M208470200DOI Listing
March 2003
1 Read
4.573 Impact Factor

Beta7 integrins contribute to skin graft rejection.

Transplantation 2002 Oct;74(8):1202-3

Department of Molecular Medicine and Pathology, Faculty of Medicine and Health Science, University of Auckland, 85 Park Road, Grafton, New Zealand.

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http://dx.doi.org/10.1097/00007890-200210270-00029DOI Listing
October 2002
3 Reads
3.828 Impact Factor

IMGT, the international ImMunoGeneTics database: a new design for immunogenetics data access.

Stud Health Technol Inform 1998 ;52 Pt 1:351-5

Laboratoire d'ImmunoGénétique Moléculaire, LIGM, UMR 5535 (CNRS, Université Montpellier II), France.

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July 1999

Efficient lymphocyte migration across high endothelial venules of mouse Peyer's patches requires overlapping expression of L-selectin and beta7 integrin.

J Immunol 1998 Dec;161(12):6638-47

Department of Immunology, Duke University Medical Center, Durham, NC 27710, USA.

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December 1998
2 Reads
4.922 Impact Factor

IL-10 regulates liver pathology in acute murine Schistosomiasis mansoni but is not required for immune down-modulation of chronic disease.

J Immunol 1998 May;160(9):4473-80

Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

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May 1998
4.922 Impact Factor

Analysis of granuloma formation in double cytokine-deficient mice reveals a central role for IL-10 in polarizing both T helper cell 1- and T helper cell 2-type cytokine responses in vivo.

J Immunol 1997 Nov;159(10):5014-23

Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892-0425, USA.

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November 1997
4.922 Impact Factor

Bypass of lethality with mosaic mice generated by Cre-loxP-mediated recombination.

Curr Biol 1996 Oct;6(10):1307-16

Institute for Genetics, University of Cologne, Germany.

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http://dx.doi.org/10.1016/s0960-9822(02)70717-3DOI Listing
October 1996
3 Reads
9.571 Impact Factor

In the absence of endogenous IL-10, mice acutely infected with Toxoplasma gondii succumb to a lethal immune response dependent on CD4+ T cells and accompanied by overproduction of IL-12, IFN-gamma and TNF-alpha.

J Immunol 1996 Jul;157(2):798-805

Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA.

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July 1996
3 Reads
4.922 Impact Factor

A genetic approach for the analysis of cytokine function in vivo.

Authors:
W Müller

Behring Inst Mitt 1995 Jun(96):95-6

Institut für Genetik, Universität zu Köln, Germany.

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June 1995

IL-9 production of naive CD4+ T cells depends on IL-2, is synergistically enhanced by a combination of TGF-beta and IL-4, and is inhibited by IFN-gamma.

J Immunol 1994 Nov;153(9):3989-96

Institute for Immunology, University of Mainz, Germany.

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November 1994
4.922 Impact Factor

Interleukin-10-deficient mice develop chronic enterocolitis.

Cell 1993 Oct;75(2):263-74

Institute for Genetics, University of Cologne, Federal Republic of Germany.

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http://dx.doi.org/10.1016/0092-8674(93)80068-pDOI Listing
October 1993
32.242 Impact Factor

CD5 B cells in the mouse.

Curr Top Microbiol Immunol 1991 ;173:247-51

Institute for Genetics, University of Cologne, FRG.

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http://dx.doi.org/10.1007/978-3-642-76492-9_35DOI Listing
November 1991
4.097 Impact Factor

Membrane-bound IgM obstructs B cell development in transgenic mice.

Eur J Immunol 1989 May;19(5):923-8

Institute for Genetics, University of Cologne, FRG.

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http://dx.doi.org/10.1002/eji.1830190520DOI Listing
May 1989
4.034 Impact Factor

Lymphokines regulate immunoglobulin isotype expression in an antigen-specific immune response.

J Immunol 1986 Apr;136(8):2892-5

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April 1986
4.922 Impact Factor

Signal requirements for growth and differentiation of activated murine B lymphocytes.

J Immunol 1985 Aug;135(2):1213-9

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August 1985
3 Reads
4.922 Impact Factor

Top co-authors

Werner Muller
Werner Muller

University of Manchester

86
Axel Roers
Axel Roers

University of Cologne

19
Angela Schippers
Angela Schippers

Hannover Medical School

12
Ari Waisman
Ari Waisman

Institute for Molecular Medicine

12
Oliver Pabst
Oliver Pabst

Hannover Medical School

7
Thomas Krieg
Thomas Krieg

University of Cambridge

6
Norbert Wagner
Norbert Wagner

RWTH Aachen University

6
Thorsten Peters
Thorsten Peters

University of Ulm

5
Emmanuel Pinteaux
Emmanuel Pinteaux

University of Manchester

5