Publications by authors named "Werner Falk"

61Publications

A refined and translationally relevant model of chronic DSS colitis in BALB/c mice.

Lab Anim 2018 Jun 1;52(3):240-252. Epub 2017 Dec 1.

1 Department of Therapy Validation, Fraunhofer Institute for Cell Therapy and Immunology, Leipzig, Germany.

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http://dx.doi.org/10.1177/0023677217742681DOI Listing
June 2018

Identification of critical regions within the TIR domain of IL-1 receptor type I.

Int J Biochem Cell Biol 2015 Nov 14;68:15-20. Epub 2015 Aug 14.

Institute of Pharmacy, University of Regensburg, D-93040 Regensburg, Germany.

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http://dx.doi.org/10.1016/j.biocel.2015.08.009DOI Listing
November 2015

Galectin-3 Modulates Experimental Colitis.

Digestion 2015 17;92(1):45-53. Epub 2015 Jul 17.

Department of Internal Medicine I, University Hospital Regensburg, Regensburg, Germany.

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http://dx.doi.org/10.1159/000431312DOI Listing
April 2016

Exogenous heat shock protein gp96 ameliorates CD4+CD62L+ T-cell-mediated transfer colitis.

Inflamm Bowel Dis 2014 Nov;20(11):1933-41

*Division of Gastroenterology and Hepatology, University Hospital Zurich, University of Zurich, Zurich, Switzerland; and †Department of Internal Medicine I, University of Regensburg, Regensburg, Germany.

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http://dx.doi.org/10.1097/MIB.0000000000000175DOI Listing
November 2014

IL-33 attenuates development and perpetuation of chronic intestinal inflammation.

Inflamm Bowel Dis 2012 Oct 16;18(10):1900-9. Epub 2012 Apr 16.

Department of Internal Medicine I, University Hospital Regensburg, Germany.

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http://dx.doi.org/10.1002/ibd.22900DOI Listing
October 2012

(-)-Epigallocatechin-3-gallate, a green tea-derived catechin, synergizes with celecoxib to inhibit IL-1-induced tumorigenic mediators by human pancreatic adenocarcinoma cells Colo357.

Eur J Pharmacol 2012 Jun 3;684(1-3):36-43. Epub 2012 Apr 3.

Institute of Medical Biochemistry and Molecular Biology, University of Greifswald, D-17487 Greifswald, Germany.

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http://dx.doi.org/10.1016/j.ejphar.2012.03.039DOI Listing
June 2012

Intracellular survival of Staphylococcus aureus in adipocyte-like differentiated 3T3-L1 cells is glucose dependent and alters cytokine, chemokine, and adipokine secretion.

Endocrinology 2011 Nov 13;152(11):4148-57. Epub 2011 Sep 13.

Department of Internal Medicine I, University Hospital Regensburg, Franz-Josef-Strauss Allee 11, 93042 Regensburg, Germany.

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https://academic.oup.com/endo/article-lookup/doi/10.1210/en.
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http://dx.doi.org/10.1210/en.2011-0103DOI Listing
November 2011

Interleukin-33 prolongs allograft survival during chronic cardiac rejection.

Transpl Int 2011 Oct 28;24(10):1027-39. Epub 2011 Jul 28.

Department of Surgery, University Medical Center Regensburg, Regensburg, Germany.

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http://dx.doi.org/10.1111/j.1432-2277.2011.01306.xDOI Listing
October 2011

EGCG downregulates IL-1RI expression and suppresses IL-1-induced tumorigenic factors in human pancreatic adenocarcinoma cells.

Biochem Pharmacol 2011 Nov 20;82(9):1153-62. Epub 2011 Jul 20.

Institut für Medizinische Biochemie und Molekularbiologie, Ernst-Moritz-Arndt-Universität, D-17487 Greifswald, Germany.

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http://dx.doi.org/10.1016/j.bcp.2011.07.063DOI Listing
November 2011

Inflammatory bowel diseases: when natural friends turn into enemies-the importance of CpG motifs of bacterial DNA in intestinal homeostasis and chronic intestinal inflammation.

Int J Inflam 2010 Aug 16;2010:641910. Epub 2010 Aug 16.

Department of Internal Medicine I, University of Regensburg, 93042 Regensburg, Germany.

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http://dx.doi.org/10.4061/2010/641910DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3003983PMC
August 2010

Glycogen synthase kinase 3-β: a master regulator of toll-like receptor-mediated chronic intestinal inflammation.

Inflamm Bowel Dis 2010 Nov;16(11):1850-8

Department of Internal Medicine I, Regensburg University Medical Center, Germany.

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https://academic.oup.com/ibdjournal/article/16/11/1850-1858/
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http://dx.doi.org/10.1002/ibd.21294DOI Listing
November 2010

C1q/TNF-related protein-3 represents a novel and endogenous lipopolysaccharide antagonist of the adipose tissue.

Endocrinology 2010 Nov 25;151(11):5267-78. Epub 2010 Aug 25.

Department of Internal Medicine I, University of Regensburg, D-93042 Regensburg, Germany.

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http://dx.doi.org/10.1210/en.2010-0571DOI Listing
November 2010

Association of the NOD2 genotype with bacterial translocation via altered cell-cell contacts in Crohn's disease patients.

Inflamm Bowel Dis 2010 Aug;16(8):1311-21

University of Regensburg, Department of Internal Medicine I, Regensburg, Germany.

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http://dx.doi.org/10.1002/ibd.21223DOI Listing
August 2010

Caspase 3 inactivates biologically active full length interleukin-33 as a classical cytokine but does not prohibit nuclear translocation.

Biochem Biophys Res Commun 2010 Jan 24;391(3):1512-6. Epub 2009 Dec 24.

Immunology FB 08, Justus-Liebig-University, Winchesterstrasse 2, 35394 Giessen, Germany.

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http://dx.doi.org/10.1016/j.bbrc.2009.12.107DOI Listing
January 2010

Primary human colonic epithelial cells are transiently protected from anoikis by a Src-dependent mechanism.

Biochem Biophys Res Commun 2009 Dec 21;390(3):908-14. Epub 2009 Oct 21.

Department of Internal Medicine I, Regensburg University Medical Center, 93042 Regensburg, Germany.

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http://linkinghub.elsevier.com/retrieve/pii/S0006291X0902066
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http://dx.doi.org/10.1016/j.bbrc.2009.10.075DOI Listing
December 2009

Lipopolysaccharide-trap-Fc, a multifunctional agent to battle gram-negative bacteria.

Infect Immun 2009 Jul 11;77(7):2925-31. Epub 2009 May 11.

Department of Internal Medicine I, University of Regensburg, Regensburg, Germany.

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http://dx.doi.org/10.1128/IAI.00004-09DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2708546PMC
July 2009

CpG motifs of bacterial DNA exert protective effects in mouse models of IBD by antigen-independent tolerance induction.

Gastroenterology 2009 Jan 25;136(1):278-87. Epub 2008 Sep 25.

Institute for Laboratory Animal Science and Central Animal Facility, Hannover Medical School, Hannover, Germany.

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http://dx.doi.org/10.1053/j.gastro.2008.09.022DOI Listing
January 2009

A TLR4/MD2 fusion protein inhibits LPS-induced pro-inflammatory signaling in hepatic stellate cells.

Biochem Biophys Res Commun 2008 Oct 9;375(2):210-4. Epub 2008 Aug 9.

Department of Medicine, University of California San Diego, 9500 Gilman Drive, MC0702, La Jolla, CA 92093, USA.

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http://dx.doi.org/10.1016/j.bbrc.2008.07.150DOI Listing
October 2008

Inflammation modulates fibronectin isoform expression in colonic lamina propria fibroblasts (CLPF).

Int J Colorectal Dis 2008 Oct 17;23(10):947-55. Epub 2008 Jul 17.

Department of Internal Medicine II, University of Jena, 07747 Jena, Germany.

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http://dx.doi.org/10.1007/s00384-008-0523-zDOI Listing
October 2008

Increased chromogranin A levels indicate sympathetic hyperactivity in patients with rheumatoid arthritis and systemic lupus erythematosus.

J Rheumatol 2008 Jan 1;35(1):91-9. Epub 2007 Dec 1.

Department of Internal Medicine I, University Hospital Regensburg, Regensburg, Germany.

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http://www.jrheum.org/content/35/1/91.full.pdf
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January 2008

IL-1 receptor accessory protein is essential for IL-33-induced activation of T lymphocytes and mast cells.

Proc Natl Acad Sci U S A 2007 Nov 14;104(47):18660-5. Epub 2007 Nov 14.

Immunology FB08, Justus-Liebig-University Giessen, Winchesterstrasse 2, D-35394 Giessen, Germany.

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http://dx.doi.org/10.1073/pnas.0705939104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2141833PMC
November 2007

13-Oxo-ODE is an endogenous ligand for PPARgamma in human colonic epithelial cells.

Biochem Pharmacol 2007 Aug 7;74(4):612-22. Epub 2007 Jun 7.

Department of Internal Medicine I, University of Regensburg, 93042 Regensburg, Germany.

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http://dx.doi.org/10.1016/j.bcp.2007.05.027DOI Listing
August 2007

Cell-cell contacts prevent anoikis in primary human colonic epithelial cells.

Gastroenterology 2007 Feb 16;132(2):587-600. Epub 2006 Nov 16.

Department of Internal Medicine I, University of Regensburg, Regensburg, Germany.

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http://dx.doi.org/10.1053/j.gastro.2006.11.017DOI Listing
February 2007

Evidence for a differential expression of fibronectin splice forms ED-A and ED-B in Crohn's disease (CD) mucosa.

Int J Colorectal Dis 2007 Jun 30;22(6):611-23. Epub 2006 Nov 30.

Department of Internal Medicine I, University of Regensburg, 93042, Regensburg, Germany.

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http://dx.doi.org/10.1007/s00384-006-0188-4DOI Listing
June 2007

p38MAPK mediates IL-1-induced down-regulation of aggrecan gene expression in human chondrocytes.

Int J Mol Med 2006 Apr;17(4):661-8

Abteilung Hämatologie und Internistische Onkologie, Universitätsklinikum Regensburg, D-93053 Regensburg, Germany.

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April 2006

Interleukin-10 does not affect IL-1-induced interleukin-6 and metalloproteinase production in human chondrosarcoma cells, SW1353.

Int J Mol Med 2006 Feb;17(2):377-83

Abteilung Hämatologie und Internistische Onkologie, Universität Regensburg, D-93053 Regensburg, Germany.

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February 2006

A designed TLR4/MD-2 complex to capture LPS.

J Endotoxin Res 2005 ;11(4):197-206

Department of Internal Medicine I, University of Regensburg, Regensburg, Germany.

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http://dx.doi.org/10.1179/096805105X58670DOI Listing
November 2005

Immune status and risk for infection in patients receiving chronic immunosuppressive therapy.

J Rheumatol 2005 Aug;32(8):1473-80

Division of Infectious Diseases, Division of Rheumatology, Department of Internal Medicine I, University Medical Center, University of Regensburg, Germany.

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August 2005

Ursodeoxycholic acid induced activation of the glucocorticoid receptor in primary rat hepatocytes.

Eur J Gastroenterol Hepatol 2005 Feb;17(2):169-77

Department of Internal Medicine, Klinik Lindenberg-Ried, Lindenberg, Germany.

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http://dx.doi.org/10.1097/00042737-200502000-00007DOI Listing
February 2005

Autocrine fibronectin-induced migration of human colonic fibroblasts.

Am J Gastroenterol 2004 Feb;99(2):335-40

Department of Internal Medicine I, University Hospital of Regensburg, 93042 Regensburg, Germany.

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http://dx.doi.org/10.1111/j.1572-0241.2004.04044.xDOI Listing
February 2004

OX40/OX40L interaction induces the expression of CXCR5 and contributes to chronic colitis induced by dextran sulfate sodium in mice.

Eur J Immunol 2003 Dec;33(12):3265-74

Department of Internal Medicine I, University of Regensburg, Regensburg, Germany.

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http://dx.doi.org/10.1002/eji.200324124DOI Listing
December 2003

The interleukin 1 (IL-1) receptor accessory protein Toll/IL-1 receptor domain: analysis of putative interaction sites in vitro mutagenesis and molecular modeling.

J Biol Chem 2003 Dec 17;278(49):49145-53. Epub 2003 Sep 17.

Klinik und Poliklinik für Innere Medizin I, Universität Regensburg, D-93042 Regensburg, Germany.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M306077200
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http://dx.doi.org/10.1074/jbc.M306077200DOI Listing
December 2003

Immunomodulatory consequences of oral administration of Lactobacillus rhamnosus strain GG in healthy volunteers.

J Dairy Res 2003 May;70(2):165-73

Department of Internal Medicine I, University of Regensburg, Regensburg, Germany.

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http://dx.doi.org/10.1017/s0022029903006034DOI Listing
May 2003

Serum levels of pregnenolone and 17-hydroxypregnenolone in patients with rheumatoid arthritis and systemic lupus erythematosus: relation to other adrenal hormones.

J Rheumatol 2003 Feb;30(2):269-75

Department of Internal Medicine I, Laboratory of Neuroendocrinoimmunology, University Medical Center Regensburg, Regensberg, Germany.

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February 2003

CpG motifs of bacterial DNA exacerbate colitis of dextran sulfate sodium-treated mice.

Eur J Immunol 2002 Jul;32(7):2084-92

Department of Internal Medicine I, University of Regensburg, Regensburg, Germany.

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http://dx.doi.org/10.1002/1521-4141(200207)32:7<2084::AID-IMMU2084>3.0.CO;2-QDOI Listing
July 2002

Uncoupling of the sympathetic nervous system and the hypothalamic-pituitary-adrenal axis in inflammatory bowel disease?

J Neuroimmunol 2002 May;126(1-2):116-25

Laboratory of Neuroendocrinoimmunology, Department of Internal Medicine I, University Hospital Regensburg, 93042, Germany.

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http://dx.doi.org/10.1016/s0165-5728(02)00047-4DOI Listing
May 2002

Immunoregulation of IL-6 secretion by endogenous and exogenous adenosine and by exogenous purinergic agonists in splenic tissue slices.

J Neuroimmunol 2002 Apr;125(1-2):73-81

Laboratory of Neuroendocrinoimmunology, Department of Internal Medicine I, University Hospital Regensburg, 93042 Regensburg, Germany.

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http://dx.doi.org/10.1016/s0165-5728(02)00035-8DOI Listing
April 2002

Identification of essential regions in the cytoplasmic tail of interleukin-1 receptor accessory protein critical for interleukin-1 signaling.

J Biol Chem 2002 May 5;277(19):16456-63. Epub 2002 Mar 5.

Klinik und Poliklinik für Innere Medizin I, Universität Regensburg, D-93042 Regensburg, Germany.

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http://dx.doi.org/10.1074/jbc.M201000200DOI Listing
May 2002