Publications by authors named "Wenyuan Ma"

6 Publications

  • Page 1 of 1

Corilagin induces apoptosis and autophagy in NRF2‑addicted U251 glioma cell line.

Mol Med Rep 2021 May 24;23(5). Epub 2021 Mar 24.

Department of Radiology and Medical Imaging, University of Virginia, Charlottesville, VA 22908, USA.

Corilagin, extracted from the Euphorbiaceae and plants, inhibits the growth of a number of types of tumors. Compared with temozolomide, the traditional chemotherapy drug, corilagin has demonstrated stronger antitumor activity. However, the pharmaceutical mechanism of corilagin in glioma remains unclear. Nuclear factor erythroid 2 like 2 (NFE2L2 or NRF2) is positively associated with several types of tumor including glioma. In the present study, NRF2 expression was higher in glioma tissues compared with non‑glioma specimens. Therefore, it was hypothesized that corilagin targets NRF2 regulation of U251 cell apoptosis. The present study used Hoechst 33258 staining to demonstrate that corilagin induced glioma cell apoptosis and observed that the expression of the apoptosis‑related gene Bcl‑2 was reduced. In addition, corilagin induced autophagy and promoted the conversion of light chain 3 (LC3) protein from LC3Ⅰ to LC3II. NRF2 expression was downregulated by corilagin stimulation. Furthermore, the gene expression pattern following knockdown of NRF2 in U251 cells using siRNA was consistent with corilagin stimulation. Therefore, it was preliminarily concluded that corilagin induces apoptosis and autophagy by reducing NRF2 expression.
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http://dx.doi.org/10.3892/mmr.2021.11959DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7974271PMC
May 2021

Corilagin induces human glioblastoma U251 cell apoptosis by impeding activity of (immuno)proteasome.

Oncol Rep 2021 Apr 2;45(4):1-11. Epub 2021 Mar 2.

Department of Radiology and Medical Imaging, University of Virginia, Charlottesville, VA 22908, USA.

Glioma is a type of common primary intracranial tumor, which is difficult to treat. It has been confirmed by research that corilagin (the primary active constituent of the matsumura leafflower herb) has significant antitumor effect. In particular, our previous research demonstrated that corilagin effectively promotes apoptosis of glioma U251 cells and has a synergistic effect when used with temozolomide. However, the mechanism by which corilagin causes apoptosis in U251 cells has yet to be investigated. Proteasomes are catalytic centers of the ubiquitin‑proteasome system, which is the major protein degradation pathway in eukaryotic cells; they are primarily responsible for the degradation of signal molecules, tumor suppressors, cyclins and apoptosis inhibitors and serve an important role in tumor cell proliferation and apoptosis. The present study investigated the pro‑apoptotic effect of corilagin on glioma U251 cells and confirmed that decreased proteasome activity and expression levels serve an important role in corilagin‑induced U251 cell apoptosis.
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http://dx.doi.org/10.3892/or.2021.7985DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7905533PMC
April 2021

Individual Social Capital and Life Satisfaction among Mainland Chinese Adults: Based on the 2016 China Family Panel Studies.

Int J Environ Res Public Health 2021 01 8;18(2). Epub 2021 Jan 8.

Department of Epidemiology and Biostatistics, School of Public Health, Jilin University, No. 1163 Xinmin Street, Changchun 130021, China.

Background: At present, most Chinese adults are under great psychological pressure, which seriously affects the improvement of life satisfaction. The purpose of this study was to shed light on the associations between individual social capital and life satisfaction among mainland Chinese adults.

Methods: We used a nationally representative dataset called 2016 China Family Panel Studies, and a total of 26,009 people suited our study requirements. Chi-squared test and binary regression analysis were used to determine the relationship between individual social capital and life satisfaction among mainland Chinese adults.

Results: The results indicated that cognitive social capital had significant effects on life satisfaction ( < 0.05), but the impact of structural social capital on life satisfaction became less significant when combined with sociodemographic variables and socioeconomic status (SES) ( > 0.05). Moreover, we also found that life satisfaction was better in married/cohabited ( < 0.05) and in over 65 age group people ( < 0.05). Self-rated income level, self-rated social status, and self-rated health all had positive effects on life satisfaction ( < 0.001).

Conclusions: Given the stabilizing effect of cognitive social capital at the individual level on life satisfaction, the government should attach great importance to this aspect when trying to improve adults' life satisfaction.
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http://dx.doi.org/10.3390/ijerph18020441DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7827718PMC
January 2021

Molecular Characterization and Chemotactic Function of CXCL8 in Northeast Chinese Lamprey ().

Front Immunol 2020 18;11:1738. Epub 2020 Aug 18.

Key Laboratory of Exploration and Utilization of Aquatic Genetic Resources, Ministry of Education, Shanghai Ocean University, Shanghai, China.

Chemokine-induced chemotaxis of leukocytes is an important part of the innate immunity and has been shown to mediate inflammation in all groups of jawed vertebrates. For jawless vertebrates, hagfish leukocytes are known to show chemotaxis toward mammalian complement anaphylotoxin and Gram-negative bacteria lipopolysaccharide. However, whether chemokines mediate chemotaxis of leukocytes in jawless vertebrates has not been conclusively examined. Here, we show C-X-C motif chemokine ligand 8 (CXCL8, also named interleukin 8) of the Northeast Chinese lamprey () (designated as LmCXCL8) induces chemotaxis in its leukocytes. We identified LmCXCL8 and found it possesses the characteristic N-terminal cysteine residues and GGR (Gly-Gly-Arg) motif. The gene was found to be expressed in all examined tissues, and its expression was inducible in the lamprey challenged by an infectious bacterium, . A recombinant LmCXCL8 protein elicited concentration-dependent chemotaxis in peripheral blood leukocytes isolated from the Northeast Chinese lamprey. Based on these results, we conclude that LmCXCL8 is a constitutive and inducible acute-phase cytokine that mediates immune defense and trace the chemotactic function of chemokine to basal vertebrates.
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http://dx.doi.org/10.3389/fimmu.2020.01738DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7461807PMC
August 2020

Serum Uric Acid and Triglycerides in Chinese Patients with Newly Diagnosed Moyamoya Disease: A Cross-Sectional Study.

Biomed Res Int 2019 2;2019:9792412. Epub 2019 Jul 2.

Department of Neurosurgery, Affiliated Hospital of Jining Medical University & Shandong Provincial Key Laboratory of Stem Cells and Neuro-oncology, Jining, Shandong 272029, China.

Background: Evidence regarding the relationship between serum uric acid and triglycerides is limited. Therefore, the specific objective of this study was to investigate whether serum uric acid was independently related to triglycerides in Chinese patients with newly diagnosed moyamoya disease after adjusting for other covariates.

Methods: The present study was a cross-sectional study. A total of 261 Chinese patients with newly diagnosed moyamoya disease were recruited from a hospital in China from 24 March 2013 to 24 December 2018. The independent variable and the dependent variable were serum uric acid measured at baseline and triglycerides, respectively. The covariates involved in this study included age, sex, body mass index, smoking status, and alcohol consumption.

Results: The average age of the 227 selected participants was 47.5 ± 12.6 years old, and approximately 48.5% of them were male. The results of the fully adjusted linear regression showed that serum uric acid (10 mol/L) was positively associated with triglycerides (mmol/L) after adjusting for confounders ( 0.048, 95% CI 0.032, 0.064).

Conclusions: In patients with moyamoya disease, there seemed to be a positive association between serum uric acid and triglycerides.
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http://dx.doi.org/10.1155/2019/9792412DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6634014PMC
January 2020

[An experimental investigation of deep burn by constant low heat].

Zhonghua Shao Shang Za Zhi 2002 Apr;18(2):99-101

Department of Burns, The First People's Hospital of Zhengzhou, Zhengzhou 450004, Henan Prorince, P.R. China.

Objective: To investigate the basic pathogenetic rule and mechanism of deep burn by constant low heat.

Methods: Animal burn model inflicted by constant low heat was established as follows. (1) The rats were randomly divided into groups in terms of temperature and duration of contact. The burn wound formation process, the skin tissue density and pathomorphological changes in the rats were observed after burn was produced on the back by contacting heat source constantly. (2) The subcutaneous temperature of the back was monitored at different time and temperatures of heat contacting by placing the thermometer under the fascia of the rat back.

Results: (1) The time of burn wound formation was shortened and the injury degree deepened along with the increase in the contact temperature. The rat skin density exhibited irregular hyperbola or triple curves. (2) The subcutaneous temperature exhibited a parabolic curve with fixed experimental conditions.

Conclusion: (1) The sharp increase in subcutaneous temperature leading to degeneration and necrosis might be the primary cause of deep burn. (2) The regularity of the skin tissue injury was the result of multiple effects of heat-origin injury, increase of capillary permeability and the change in tissue mass.
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April 2002