Publications by authors named "Wenyi Wei"

100Publications

Special issue: Targeting E3 ubiquitin ligases for cancer therapy.

Semin Cancer Biol 2020 Nov 13. Epub 2020 Nov 13.

Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, 02215, USA. Electronic address:

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http://dx.doi.org/10.1016/j.semcancer.2020.11.001DOI Listing
November 2020

Ubiquitin signaling in cell cycle control and tumorigenesis.

Cell Death Differ 2020 Oct 31. Epub 2020 Oct 31.

Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, 02215, USA.

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http://dx.doi.org/10.1038/s41418-020-00648-0DOI Listing
October 2020

Phosphorylation-dependent osterix degradation negatively regulates osteoblast differentiation.

FASEB J 2020 Nov 15;34(11):14930-14945. Epub 2020 Sep 15.

Center for Advanced Stem Cell and Regenerative Research, Tohoku University Graduate School of Dentistry, Sendai, Japan.

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http://dx.doi.org/10.1096/fj.202001340RDOI Listing
November 2020

The Negative Cross-Talk between SAG/RBX2/ROC2 and APC/C E3 Ligases in Regulation of Cell Cycle Progression and Drug Resistance.

Cell Rep 2020 Sep;32(10):108102

Cancer Institute of the Second Affiliated Hospital and Institute of Translational Medicine, Zhejiang University School of Medicine, Hangzhou 310029, China. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2020.108102DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7505520PMC
September 2020

Upregulation of METTL14 mediates the elevation of PERP mRNA N adenosine methylation promoting the growth and metastasis of pancreatic cancer.

Mol Cancer 2020 08 25;19(1):130. Epub 2020 Aug 25.

Department of Biliary-Pancreatic Surgery, Affiliated Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095 Jiefang Ave, Wuhan, 430030, Hubei, China.

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http://dx.doi.org/10.1186/s12943-020-01249-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7446161PMC
August 2020

WWP1 Gain-of-Function Inactivation of PTEN in Cancer Predisposition.

N Engl J Med 2020 05;382(22):2103-2116

From the Cancer Research Institute, Beth Israel Deaconess Cancer Center (Y.-R.L., T.K., J.Z., N.P., J.L., W.W., P.P.P.), and the Departments of Medicine (Y.-R.L., T.K., N.P., P.P.P.) and Pathology (J.Z., J.L., W.W., P.P.P.), Beth Israel Deaconess Medical Center, Harvard Medical School, Boston; the Genomic Medicine Institute (L.Y., Y.N., B.L., C.E.) and the Department of Quantitative Health Sciences (Y.N.), Lerner Research Institute, Cleveland Clinic, the Taussig Cancer Institute (C.E.), the Department of Genetics and Genome Sciences, Case Western Reserve University School of Medicine (C.E.), and the Germline High Risk Cancer Focus Group, Case Comprehensive Cancer Center, Case Western Reserve University (C.E.) - all in Cleveland; the Department of Radiation and Medical Oncology, Zhongnan Hospital of Wuhan University (J.Z.), and the Medical Research Institute, Wuhan University (J.Z.) - both in Wuhan, China; and the Molecular Biotechnology Center, Department of Molecular Biotechnology and Health Sciences, University of Turin, Turin, Italy (P.P.P.).

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http://dx.doi.org/10.1056/NEJMoa1914919DOI Listing
May 2020

RBR E3 ubiquitin ligases in tumorigenesis.

Semin Cancer Biol 2020 Dec 19;67(Pt 2):131-144. Epub 2020 May 19.

Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Ave., Boston, MA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.semcancer.2020.05.002DOI Listing
December 2020

The diverse roles of SPOP in prostate cancer and kidney cancer.

Nat Rev Urol 2020 Jun 30;17(6):339-350. Epub 2020 Apr 30.

Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1038/s41585-020-0314-zDOI Listing
June 2020

The CRL3 E3 ubiquitin ligase complex targets TNFAIP1 for degradation to suppress cancer cell migration.

Signal Transduct Target Ther 2020 Apr 24;5(1):42. Epub 2020 Apr 24.

Cancer Institute, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.

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http://dx.doi.org/10.1038/s41392-020-0140-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7181851PMC
April 2020

DUB-independent regulation of pVHL by OTUD6B suppresses hepatocellular carcinoma.

Protein Cell 2020 08;11(8):546-548

Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, 02115, USA.

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http://dx.doi.org/10.1007/s13238-020-00721-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7381525PMC
August 2020

The role of ubiquitination in tumorigenesis and targeted drug discovery.

Signal Transduct Target Ther 2020 Feb 29;5(1):11. Epub 2020 Feb 29.

Tongji University Cancer Center, Shanghai Tenth People's Hospital of Tongji University, School of Medicine, Tongji University, Shanghai, 200092, China.

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http://dx.doi.org/10.1038/s41392-020-0107-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7048745PMC
February 2020

FAM13A Represses AMPK Activity and Regulates Hepatic Glucose and Lipid Metabolism.

iScience 2020 Mar 22;23(3):100928. Epub 2020 Feb 22.

Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.isci.2020.100928DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7063182PMC
March 2020

Light-induced control of protein destruction by opto-PROTAC.

Sci Adv 2020 02 21;6(8):eaay5154. Epub 2020 Feb 21.

Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.

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http://dx.doi.org/10.1126/sciadv.aay5154DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7034987PMC
February 2020

PROTACs: A novel strategy for cancer therapy.

Semin Cancer Biol 2020 Dec 11;67(Pt 2):171-179. Epub 2020 Feb 11.

Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.semcancer.2020.02.006DOI Listing
December 2020

Targeting SCF E3 Ligases for Cancer Therapies.

Adv Exp Med Biol 2020 ;1217:123-146

Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1007/978-981-15-1025-0_9DOI Listing
February 2020

Oxygen sensing and adaptability won the 2019 Nobel Prize in Physiology or medicine.

Genes Dis 2019 Dec 19;6(4):328-332. Epub 2019 Oct 19.

Department of Pathology, Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1016/j.gendis.2019.10.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6889041PMC
December 2019

Functional analysis of deubiquitylating enzymes in tumorigenesis and development.

Biochim Biophys Acta Rev Cancer 2019 12 23;1872(2):188312. Epub 2019 Aug 23.

Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA. Electronic address:

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http://dx.doi.org/10.1016/j.bbcan.2019.188312DOI Listing
December 2019

SCF/GSK3β-Mediated GFI1 Degradation Suppresses Proliferation of Gastric Cancer Cells.

Cancer Res 2019 09 9;79(17):4387-4398. Epub 2019 Jul 9.

State Key Laboratory of Cell Biology, CAS Key Laboratory of Systems Biology, CAS Center for Excellence in Molecular Cell Science, Innovation Center for Cell Signaling Network, Shanghai Institute of Biochemistry and Cell Biology, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China.

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http://dx.doi.org/10.1158/0008-5472.CAN-18-4032DOI Listing
September 2019

PTEN Methylation by NSD2 Controls Cellular Sensitivity to DNA Damage.

Cancer Discov 2019 09 19;9(9):1306-1323. Epub 2019 Jun 19.

Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1158/2159-8290.CD-18-0083DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6726527PMC
September 2019

Fine-tuning AKT kinase activity through direct lysine methylation.

Cell Cycle 2019 05 3;18(9):917-922. Epub 2019 May 3.

b Department of Pathology, Beth Israel Deaconess Medical Center , Harvard Medical School , Boston , MA , USA.

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http://dx.doi.org/10.1080/15384101.2019.1609832DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6527264PMC
May 2019

Hippo signaling is intrinsically regulated during cell cycle progression by APC/C.

Proc Natl Acad Sci U S A 2019 05 18;116(19):9423-9432. Epub 2019 Apr 18.

Department of Developmental Biology, Harvard Stem Cell Institute, Harvard School of Dental Medicine, Boston, MA 02215;

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http://dx.doi.org/10.1073/pnas.1821370116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6511010PMC
May 2019

Degrading proteins in animals: "PROTAC"tion goes in vivo.

Cell Res 2019 03;29(3):179-180

Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, 02215, USA.

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http://www.nature.com/articles/s41422-019-0144-9
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http://dx.doi.org/10.1038/s41422-019-0144-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6460438PMC
March 2019

AKT methylation by SETDB1 promotes AKT kinase activity and oncogenic functions.

Nat Cell Biol 2019 02 28;21(2):226-237. Epub 2019 Jan 28.

Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1038/s41556-018-0261-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6377565PMC
February 2019

Author Correction: Dynamic ubiquitylation of Sox2 regulates proteostasis and governs neural progenitor cell differentiation.

Nat Commun 2019 01 8;10(1):173. Epub 2019 Jan 8.

State Key Laboratory of Proteomics, National Center of Protein Sciences (Beijing), Beijing Institute of Lifeomics, 100850, Beijing, China.

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http://dx.doi.org/10.1038/s41467-018-07984-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6325103PMC
January 2019

The emerging role for Cullin 4 family of E3 ligases in tumorigenesis.

Biochim Biophys Acta Rev Cancer 2019 01 30;1871(1):138-159. Epub 2018 Dec 30.

Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S0304419X183019
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http://dx.doi.org/10.1016/j.bbcan.2018.11.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7179951PMC
January 2019

SCFβ-TrCP ubiquitinates CHK1 in an AMPK-dependent manner in response to glucose deprivation.

Mol Oncol 2019 02 3;13(2):307-321. Epub 2018 Dec 3.

Key Laboratory of Combined Multi-Organ Transplantation, Ministry of Public Health, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.

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http://doi.wiley.com/10.1002/1878-0261.12403
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http://dx.doi.org/10.1002/1878-0261.12403DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360357PMC
February 2019

Dynamic ubiquitylation of Sox2 regulates proteostasis and governs neural progenitor cell differentiation.

Nat Commun 2018 11 7;9(1):4648. Epub 2018 Nov 7.

State Key Laboratory of Proteomics, National Center of Protein Sciences (Beijing), Beijing Institute of Lifeomics, 100850, Beijing, China.

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http://www.nature.com/articles/s41467-018-07025-z
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http://dx.doi.org/10.1038/s41467-018-07025-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6220269PMC
November 2018

Biochemical Aspects of PD-L1 Regulation in Cancer Immunotherapy.

Trends Biochem Sci 2018 12 1;43(12):1014-1032. Epub 2018 Oct 1.

Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S09680004183018
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http://dx.doi.org/10.1016/j.tibs.2018.09.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6252278PMC
December 2018

SCF-mediated degradation of Brg1 suppresses gastric cancer metastasis.

Nat Commun 2018 09 3;9(1):3569. Epub 2018 Sep 3.

Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, 02215, USA.

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http://www.nature.com/articles/s41467-018-06038-y
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http://dx.doi.org/10.1038/s41467-018-06038-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6120942PMC
September 2018

The emerging roles of protein homeostasis-governing pathways in Alzheimer's disease.

Aging Cell 2018 Oct 10;17(5):e12801. Epub 2018 Jul 10.

Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1111/acel.12801DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6156496PMC
October 2018

Mutually exclusive acetylation and ubiquitylation of the splicing factor SRSF5 control tumor growth.

Nat Commun 2018 06 25;9(1):2464. Epub 2018 Jun 25.

State Key Laboratory of Proteomics, Beijing Proteome Research Center, National Center of Protein Sciences (Beijing), Beijing Institute of Lifeomics, Beijing, 100850, China.

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http://www.nature.com/articles/s41467-018-04815-3
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http://dx.doi.org/10.1038/s41467-018-04815-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6018636PMC
June 2018

UBE2M Is a Stress-Inducible Dual E2 for Neddylation and Ubiquitylation that Promotes Targeted Degradation of UBE2F.

Mol Cell 2018 06;70(6):1008-1024.e6

Division of Radiation and Cancer Biology, Department of Radiation Oncology, University of Michigan, Ann Arbor, MI 48109, USA; Institute of Translational Medicine, Zhejiang University School of Medicine, Hangzhou, Zhejiang, PRC. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S10972765183044
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http://dx.doi.org/10.1016/j.molcel.2018.06.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6021141PMC
June 2018

K63-linked polyubiquitin chains bind to DNA to facilitate DNA damage repair.

Sci Signal 2018 06 5;11(533). Epub 2018 Jun 5.

Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1126/scisignal.aar8133DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6434707PMC
June 2018

The p85 isoform of the kinase S6K1 functions as a secreted oncoprotein to facilitate cell migration and tumor growth.

Sci Signal 2018 03 27;11(523). Epub 2018 Mar 27.

Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.

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http://dx.doi.org/10.1126/scisignal.aao1052DOI Listing
March 2018

Skp2-dependent reactivation of AKT drives resistance to PI3K inhibitors.

Sci Signal 2018 03 13;11(521). Epub 2018 Mar 13.

Department of Pathology, Medicine and Cancer Center, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.

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http://dx.doi.org/10.1126/scisignal.aao3810DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5902813PMC
March 2018

Physiological functions of FBW7 in cancer and metabolism.

Cell Signal 2018 06 21;46:15-22. Epub 2018 Feb 21.

Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, United States. Electronic address:

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http://dx.doi.org/10.1016/j.cellsig.2018.02.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5882551PMC
June 2018

The mTOR-S6K pathway links growth signalling to DNA damage response by targeting RNF168.

Nat Cell Biol 2018 03 5;20(3):320-331. Epub 2018 Feb 5.

State Key Laboratory of Cell Biology, CAS Key Laboratory of Systems Biology, CAS Center for Excellence in Molecular Cell Science, Innovation Center for Cell Signaling Network, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai, China.

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http://dx.doi.org/10.1038/s41556-017-0033-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5826806PMC
March 2018

Deregulated PP1α phosphatase activity towards MAPK activation is antagonized by a tumor suppressive failsafe mechanism.

Nat Commun 2018 01 15;9(1):159. Epub 2018 Jan 15.

Cancer Research Institute, Beth Israel Deaconess Cancer Center, Department of Medicine and Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, 02215, USA.

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http://dx.doi.org/10.1038/s41467-017-02272-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5768788PMC
January 2018

USP21 deubiquitylates Nanog to regulate protein stability and stem cell pluripotency.

Signal Transduct Target Ther 2016 4;1:16024. Epub 2016 Nov 4.

State Key Laboratory of Proteomics, Beijing Proteome Research Center, Beijing Institute of Radiation Medicine, Collaborative Innovation Center for Cancer Medicine, Beijing, China.

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http://dx.doi.org/10.1038/sigtrans.2016.24DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5661642PMC
November 2016

Functional analysis of Cullin 3 E3 ligases in tumorigenesis.

Biochim Biophys Acta Rev Cancer 2018 Jan 8;1869(1):11-28. Epub 2017 Nov 8.

Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA. Electronic address:

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http://dx.doi.org/10.1016/j.bbcan.2017.11.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7076836PMC
January 2018

SPOP-mediated degradation of BRD4 dictates cellular sensitivity to BET inhibitors.

Cell Cycle 2017 ;16(24):2326-2329

a Department of Pathology , Beth Israel Deaconess Medical Center, Harvard Medical School , Boston , MA , USA.

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http://dx.doi.org/10.1080/15384101.2017.1388973DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5788415PMC
July 2019

E3 ubiquitin ligases in cancer and implications for therapies.

Cancer Metastasis Rev 2017 12;36(4):683-702

Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Ave, Boston, MA, 02215, USA.

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http://dx.doi.org/10.1007/s10555-017-9703-zDOI Listing
December 2017

Functional analyses of major cancer-related signaling pathways in Alzheimer's disease etiology.

Biochim Biophys Acta Rev Cancer 2017 Dec 8;1868(2):341-358. Epub 2017 Jul 8.

Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA. Electronic address:

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http://dx.doi.org/10.1016/j.bbcan.2017.07.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5675793PMC
December 2017

TRAF2 and OTUD7B govern a ubiquitin-dependent switch that regulates mTORC2 signalling.

Nature 2017 05 10;545(7654):365-369. Epub 2017 May 10.

Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA.

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http://dx.doi.org/10.1038/nature22344DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5695540PMC
May 2017

"FEM1"nism controls SLBP stability during cell cycle.

Cell Cycle 2017 04;16(7):597-598

a Department of Pathology , Beth Israel Deaconess Medical Center, Harvard Medical School , Boston , MA , USA.

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http://dx.doi.org/10.1080/15384101.2017.1302226DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5397267PMC
April 2017

A covalently bound inhibitor triggers EZH2 degradation through CHIP-mediated ubiquitination.

EMBO J 2017 05 20;36(9):1243-1260. Epub 2017 Mar 20.

Faculty of Oral and Maxillofacial Surgery, Department of Oral and Maxillofacial Head & Neck Oncology, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China

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http://emboj.embopress.org/lookup/doi/10.15252/embj.20169405
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http://dx.doi.org/10.15252/embj.201694058DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5412902PMC
May 2017

Acetylation-dependent regulation of MDM2 E3 ligase activity dictates its oncogenic function.

Sci Signal 2017 02 14;10(466). Epub 2017 Feb 14.

Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1126/scisignal.aai8026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5468793PMC
February 2017

Tumor suppressor SPOP ubiquitinates and degrades EglN2 to compromise growth of prostate cancer cells.

Cancer Lett 2017 04 13;390:11-20. Epub 2017 Jan 13.

Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA. Electronic address:

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http://dx.doi.org/10.1016/j.canlet.2017.01.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5511705PMC
April 2017

Prostate cancer-associated mutation in SPOP impairs its ability to target Cdc20 for poly-ubiquitination and degradation.

Cancer Lett 2017 01 22;385:207-214. Epub 2016 Oct 22.

Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA. Electronic address:

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http://dx.doi.org/10.1016/j.canlet.2016.10.021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5148662PMC
January 2017

Functional characterization of AMP-activated protein kinase signaling in tumorigenesis.

Biochim Biophys Acta 2016 12 25;1866(2):232-251. Epub 2016 Sep 25.

Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA. Electronic address:

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http://dx.doi.org/10.1016/j.bbcan.2016.09.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5483337PMC
December 2016

New Insights into Protein Hydroxylation and Its Important Role in Human Diseases.

Biochim Biophys Acta 2016 12 20;1866(2):208-220. Epub 2016 Sep 20.

Lineberger Comprehensive Cancer Center, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA; Department of Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill, NC 27599, USA. Electronic address:

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http://dx.doi.org/10.1016/j.bbcan.2016.09.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5138100PMC
December 2016

A new layer of degradation mechanism for PR-Set7/Set8 during cell cycle.

Cell Cycle 2016 Nov 20;15(22):3042-3047. Epub 2016 Sep 20.

b Department of Pathology , Beth Israel Deaconess Medical Center, Harvard Medical School , Boston , MA , USA.

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http://dx.doi.org/10.1080/15384101.2016.1234552DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5134714PMC
November 2016

Neddylation E2 UBE2F Promotes the Survival of Lung Cancer Cells by Activating CRL5 to Degrade NOXA via the K11 Linkage.

Clin Cancer Res 2017 Feb 2;23(4):1104-1116. Epub 2016 Sep 2.

Division of Radiation and Cancer Biology, Department of Radiation Oncology, University of Michigan, Ann Arbor, Michigan.

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http://dx.doi.org/10.1158/1078-0432.CCR-16-1585DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5315595PMC
February 2017

Cdh1 inhibits WWP2-mediated ubiquitination of PTEN to suppress tumorigenesis in an APC-independent manner.

Cell Discov 2016 2;2:15044. Epub 2016 Feb 2.

Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School , Boston, MA, USA.

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http://dx.doi.org/10.1038/celldisc.2015.44DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4860961PMC
July 2016

Inhibition of Rb Phosphorylation Leads to mTORC2-Mediated Activation of Akt.

Mol Cell 2016 06 26;62(6):929-942. Epub 2016 May 26.

Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.

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http://dx.doi.org/10.1016/j.molcel.2016.04.023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4912424PMC
June 2016

Emerging roles of FGF signaling in hepatocellular carcinoma.

Transl Cancer Res 2016 Feb;5(1):1-6

The Cyrus Tang Hematology Center and Collaborative Innovation Center of Hematology, Jiangsu Institute of Hematology, the First Affiliated Hospital, Soochow University, Suzhou 215123, China.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4876964PMC
February 2016

Recent advances in SCF ubiquitin ligase complex: Clinical implications.

Biochim Biophys Acta 2016 08 5;1866(1):12-22. Epub 2016 May 5.

Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, MA 02215, USA. Electronic address:

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http://dx.doi.org/10.1016/j.bbcan.2016.05.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4980229PMC
August 2016

Cdh1 regulates craniofacial development via APC-dependent ubiquitination and activation of Goosecoid.

Cell Res 2016 06 29;26(6):699-712. Epub 2016 Apr 29.

State Key Laboratory of Cell Biology, CAS Center for Excellence in Molecular Cell Sciences, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China.

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http://dx.doi.org/10.1038/cr.2016.51DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4897181PMC
June 2016

Ubiquitination-mediated degradation of cell cycle-related proteins by F-box proteins.

Int J Biochem Cell Biol 2016 Apr 6;73:99-110. Epub 2016 Feb 6.

Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Ave., Boston, MA 02215, USA. Electronic address:

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http://dx.doi.org/10.1016/j.biocel.2016.02.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4798898PMC
April 2016

TGFβ3-mediated induction of Periostin facilitates head and neck cancer growth and is associated with metastasis.

Sci Rep 2016 Feb 9;6:20587. Epub 2016 Feb 9.

Department of Oral and Maxillofacial-Head &Neck Oncology and Faculty of Oral and Maxillofacial Surgery, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200011, China.

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http://www.nature.com/articles/srep20587
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http://dx.doi.org/10.1038/srep20587DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4746667PMC
February 2016

SCF(β-TRCP) promotes cell growth by targeting PR-Set7/Set8 for degradation.

Nat Commun 2015 Dec 15;6:10185. Epub 2015 Dec 15.

Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA.

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http://dx.doi.org/10.1038/ncomms10185DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4682171PMC
December 2015

SPOP Promotes Ubiquitination and Degradation of the ERG Oncoprotein to Suppress Prostate Cancer Progression.

Mol Cell 2015 Sep 3;59(6):917-30. Epub 2015 Sep 3.

Department of Pathology, Cancer Research Institute, Beth Israel Deaconess Cancer Center, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2015.07.026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4575912PMC
September 2015

The E3 ligase APC/C(Cdh1) promotes ubiquitylation-mediated proteolysis of PAX3 to suppress melanocyte proliferation and melanoma growth.

Sci Signal 2015 Sep 1;8(392):ra87. Epub 2015 Sep 1.

Department of Pharmacology and Experimental Therapeutics, Boston University Cancer Center, Boston University School of Medicine, Boston, MA 02118, USA. Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 20032, P. R. China.

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http://dx.doi.org/10.1126/scisignal.aab1995DOI Listing
September 2015

PtdIns(3,4,5)P3-Dependent Activation of the mTORC2 Kinase Complex.

Cancer Discov 2015 Nov 20;5(11):1194-209. Epub 2015 Aug 20.

Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1158/2159-8290.CD-15-0460DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4631654PMC
November 2015

Deubiquitylase OTUD3 regulates PTEN stability and suppresses tumorigenesis.

Nat Cell Biol 2015 Sep 17;17(9):1169-81. Epub 2015 Aug 17.

State Key Laboratory of Proteomics, Beijing Proteome Research Center, Beijing Institute of Radiation Medicine, Collaborative Innovation Center for Cancer Medicine, Beijing 100850, China.

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http://dx.doi.org/10.1038/ncb3218DOI Listing
September 2015

Akt promotes tumorigenesis in part through modulating genomic instability via phosphorylating XLF.

Nucleus 2015 30;6(4):261-5. Epub 2015 Jul 30.

a Department of Pathology ; Beth Israel Deaconess Medical Center ; Harvard Medical School ; Boston , MA USA.

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http://dx.doi.org/10.1080/19491034.2015.1074365DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4615635PMC
June 2016

Cell cycle status dictates effectiveness of rapamycin.

Cell Cycle 2015 30;14(16):2556-7. Epub 2015 Jun 30.

a Department of Pathology; Beth Israel Deaconess Medical Center; Harvard Medical School ; Boston , MA USA.

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http://dx.doi.org/10.1080/15384101.2015.1060778DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5242318PMC
April 2016

Targeting Cdc20 as a novel cancer therapeutic strategy.

Pharmacol Ther 2015 Jul 4;151:141-51. Epub 2015 Apr 4.

Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, MA 02215, USA. Electronic address:

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http://dx.doi.org/10.1016/j.pharmthera.2015.04.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4457591PMC
July 2015

Akt-mediated phosphorylation of XLF impairs non-homologous end-joining DNA repair.

Mol Cell 2015 Feb 5;57(4):648-661. Epub 2015 Feb 5.

Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2015.01.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4336609PMC
February 2015

K-ras-driven engineered mouse models for pancreatic cancer.

Discov Med 2015 Jan;19(102):15-21

The Cyrus Tang Hematology Center and Collaborative Innovation Center of Hematology, Jiangsu Institute of Hematology, the First Affiliated Hospital, Soochow University, Suzhou, Jiangsu, 215123, China.

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January 2015

The functions of F-box proteins in regulating the epithelial to mesenchymal transition.

Curr Pharm Des 2015 ;21(10):1311-7

Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Ave., Boston, MA 02215.

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http://dx.doi.org/10.2174/1381612821666141211144203DOI Listing
October 2015

Targeting the ubiquitin pathway for cancer treatment.

Biochim Biophys Acta 2015 Jan 4;1855(1):50-60. Epub 2014 Dec 4.

Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA. Electronic address:

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http://dx.doi.org/10.1016/j.bbcan.2014.11.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4312704PMC
January 2015