Wenwei Lin

Wenwei Lin

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Wenwei Lin

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Synthesis of Functionalized Benzofurans from -Quinone Methides via Phospha-1,6-Addition/-Acylation/Wittig Pathway.

Org Lett 2019 Oct 19;21(19):8008-8012. Epub 2019 Sep 19.

Department of Chemistry , National Taiwan Normal University , 88, Sec. 4, Tingchow Road , Taipei 11677 , Taiwan, R.O.C.

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http://dx.doi.org/10.1021/acs.orglett.9b03001DOI Listing
October 2019

Organophosphane-Promoted Synthesis of Functionalized α,β-Unsaturated Alkenes and Furanones via Direct β-Acylation.

Org Lett 2019 Oct 30;21(20):8339-8343. Epub 2019 Sep 30.

Department of Chemistry , National Taiwan Normal University , 88, Sec. 4, Tingchow Road , Taipei 11677 , Taiwan, R.O.C.

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http://dx.doi.org/10.1021/acs.orglett.9b03116DOI Listing
October 2019

Using TR-FRET to Investigate Protein-Protein Interactions: A Case Study of PXR-Coregulator Interaction.

Adv Protein Chem Struct Biol 2018 31;110:31-63. Epub 2017 Aug 31.

St. Jude Children's Research Hospital, Memphis, TN, United States. Electronic address:

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http://dx.doi.org/10.1016/bs.apcsb.2017.06.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5815392PMC
June 2019

An Intramolecular Wittig Approach toward Heteroarenes: Synthesis of Pyrazoles, Isoxazoles, and Chromenone-oximes.

Org Lett 2019 Jun 22;21(11):4219-4223. Epub 2019 May 22.

Department of Chemistry , National Taiwan Normal University , 88, Sec. 4, Tingchow Road , Taipei 11677 , Taiwan R.O.C.

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http://dx.doi.org/10.1021/acs.orglett.9b01395DOI Listing
June 2019

Hsa_circ_0004370 promotes esophageal cancer progression through miR-1294/LASP1 pathway.

Biosci Rep 2019 May 14;39(5). Epub 2019 May 14.

Department of Thoracic Surgery, Fujian Medical University Union Hospital, Fuzhou City, 350001 Fujian Province, China

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http://bioscirep.org/lookup/doi/10.1042/BSR20182377
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http://dx.doi.org/10.1042/BSR20182377DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6522713PMC
May 2019

Drug discovery technologies to identify and characterize modulators of the pregnane X receptor and the constitutive androstane receptor.

Drug Discov Today 2019 03 4;24(3):906-915. Epub 2019 Feb 4.

Department of Chemical Biology & Therapeutics, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA. Electronic address:

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http://dx.doi.org/10.1016/j.drudis.2019.01.021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6421094PMC
March 2019

A vinylogous Michael addition-triggered quadruple cascade reaction for the enantioselective generation of multiple quaternary stereocenters.

Chem Commun (Camb) 2019 Jan;55(10):1398-1401

Department of Chemistry, National Taiwan Normal University, 88, Sec. 4, Tingchow Road, Taipei 11677, Taiwan, Republic of China.

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http://dx.doi.org/10.1039/c8cc09219bDOI Listing
January 2019

Radical surgical resection after neoadjuvant targeted therapy in non-small cell lung cancer: a single-center retrospective study of 6 cases.

J Thorac Dis 2019 Jan;11(1):248-251

Department of Thoracic Surgery, Fujian Medical University Union Hospital, Fuzhou 350000, China.

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http://dx.doi.org/10.21037/jtd.2018.12.97DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6384356PMC
January 2019

Novel synthetic chalcone-coumarin hybrid for Aβ aggregation reduction, antioxidation, and neuroprotection.

CNS Neurosci Ther 2018 12 14;24(12):1286-1298. Epub 2018 Sep 14.

Department of Neurology, Chang Gung Memorial Hospital-Linkou Medical Center, Chang Gung University College of Medicine, Taoyuan, Taiwan.

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http://dx.doi.org/10.1111/cns.13058DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6490010PMC
December 2018

3-Homoacyl coumarin: an all carbon 1,3-dipole for enantioselective concerted (3+2) cycloaddition.

Chem Commun (Camb) 2018 Nov;54(90):12702-12705

Department of Chemistry, National Taiwan Normal University, 88, Sec. 4, Tingchow Road, Taipei 11677, Taiwan, Republic of China.

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http://xlink.rsc.org/?DOI=C8CC07271J
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http://dx.doi.org/10.1039/c8cc07271jDOI Listing
November 2018

Diversity-oriented synthesis of chromenopyrrolidines from azomethine ylides and 2-hydroxybenzylidene indandiones via base-controlled regiodivergent (3+2) cycloaddition.

Chem Commun (Camb) 2018 Sep 17;54(71):9921-9924. Epub 2018 Aug 17.

Department of Chemistry, National Taiwan Normal University, 88, Sec. 4, Tingchow Road, Taipei 11677, Taiwan, Republic of China.

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http://dx.doi.org/10.1039/c8cc05693eDOI Listing
September 2018

Identification of Toll-like receptor signaling inhibitors based on selective activation of hierarchically acting signaling proteins.

Sci Signal 2018 08 14;11(543). Epub 2018 Aug 14.

Department of Infectious Diseases, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA.

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http://dx.doi.org/10.1126/scisignal.aaq1077DOI Listing
August 2018

Diversity-Oriented Synthesis of Furo[3,2-c]coumarins and Benzofuranyl Chromenones through Chemoselective Acylation/Wittig Reaction.

Angew Chem Int Ed Engl 2018 02 5;57(6):1668-1672. Epub 2018 Jan 5.

Department of Chemistry, National Taiwan Normal University, 88, Sec. 4, Tingchow Road, Taipei, 11677, Taiwan, R.O.C.

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http://dx.doi.org/10.1002/anie.201711524DOI Listing
February 2018

High-Throughput Screening Identifies 1,4,5-Substituted 1,2,3-Triazole Analogs as Potent and Specific Antagonists of Pregnane X Receptor.

Assay Drug Dev Technol 2017 Dec 7;15(8):383-394. Epub 2017 Nov 7.

Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital , Memphis, Tennessee.

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http://dx.doi.org/10.1089/adt.2017.809DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5731549PMC
December 2017

Chemo- and Diastereoselective Michael-Michael-Acetalization Cascade for the Synthesis of 1,3-Indandione-Fused Spiro[4.5]decan Scaffolds.

J Org Chem 2017 09 17;82(17):9182-9190. Epub 2017 Aug 17.

Department of Chemistry, National Taiwan Normal University , 88, Sec. 4, Tingchow Road, Taipei, 11677 Taiwan, R.O.C.

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http://dx.doi.org/10.1021/acs.joc.7b01415DOI Listing
September 2017

Ventromorphins: A New Class of Small Molecule Activators of the Canonical BMP Signaling Pathway.

ACS Chem Biol 2017 09 29;12(9):2436-2447. Epub 2017 Aug 29.

Departments of Hematology, ‡Chemical Biology and Therapeutics, §Tumor Cell Biology, and ∥Computational Biology, St. Jude Children's Research Hospital , Memphis, Tennessee, United States.

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http://dx.doi.org/10.1021/acschembio.7b00527DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5676454PMC
September 2017

SPA70 is a potent antagonist of human pregnane X receptor.

Nat Commun 2017 09 29;8(1):741. Epub 2017 Sep 29.

Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, TN, 38105-3678, USA.

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http://dx.doi.org/10.1038/s41467-017-00780-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5622171PMC
September 2017

An enantioselective cascade for simultaneous generation of five quaternary stereocenters from fully substituted enones.

Chem Commun (Camb) 2017 Jul;53(54):7649-7652

Department of Chemistry, National Taiwan Normal University, 88, Sec. 4, Tingchow Road, Taipei 11677, Taiwan, Republic of China.

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http://dx.doi.org/10.1039/c7cc03995fDOI Listing
July 2017

Four-Component Synthesis of Phosphonium Salts: Application Toward an Alternative Approach to Cross-Coupling for the Synthesis of Bis-Heteroarenes.

Angew Chem Int Ed Engl 2017 04 3;56(18):5106-5110. Epub 2017 Apr 3.

Department of Chemistry, National Taiwan Normal University, 88, Sec. 4, Tingchow Road, Taipei, 11677, Taiwan, R.O.C.

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http://dx.doi.org/10.1002/anie.201700945DOI Listing
April 2017

Glucose-dependent regulation of pregnane X receptor is modulated by AMP-activated protein kinase.

Sci Rep 2017 04 24;7:46751. Epub 2017 Apr 24.

Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, USA.

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http://dx.doi.org/10.1038/srep46751DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5402287PMC
April 2017

EthA/R-Independent Killing of by Ethionamide.

Front Microbiol 2017 25;8:710. Epub 2017 Apr 25.

Department of Microbiology and Immunology, Yong Loo Lin School of MedicineSingapore, Singapore.

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http://dx.doi.org/10.3389/fmicb.2017.00710DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5403819PMC
April 2017

Diastereoselective Synthesis of Rauhut-Currier-Type Adducts via an Unexpected α-Addition of α,β-Unsaturated γ-Butyrolactams to Coumarin Derivatives.

J Org Chem 2017 01 12;82(1):781-789. Epub 2016 Dec 12.

Department of Chemistry, National Taiwan Normal University , 88, Sec. 4, Tingchow Road, Taipei 11677, Taiwan R.O.C.

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http://dx.doi.org/10.1021/acs.joc.6b02526DOI Listing
January 2017

Role and contribution of pulmonary CD103 dendritic cells in the adaptive immune response to Mycobacterium tuberculosis.

Tuberculosis (Edinb) 2017 01 8;102:34-46. Epub 2016 Dec 8.

Department of Microbiology, Yong Loo Lin School of Medicine, National University of Singapore (NUS), Singapore; Immunology Programme, Life Sciences Institute, NUS, Singapore. Electronic address:

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http://dx.doi.org/10.1016/j.tube.2016.12.003DOI Listing
January 2017

Identification and Characterization of CINPA1 Metabolites Facilitates Structure-Activity Studies of the Constitutive Androstane Receptor.

Drug Metab Dispos 2016 11 12;44(11):1759-1770. Epub 2016 Aug 12.

Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, Tennessee

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http://dx.doi.org/10.1124/dmd.116.071993DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5074473PMC
November 2016

tRNA-mediated codon-biased translation in mycobacterial hypoxic persistence.

Nat Commun 2016 11 11;7:13302. Epub 2016 Nov 11.

Infectious Disease Interdisciplinary Research Group, Singapore-MIT Alliance for Research and Technology, 1 CREATE Way, #03-14 Enterprise Wing, Singapore 138602, Singapore.

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http://www.nature.com/articles/ncomms13302
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http://dx.doi.org/10.1038/ncomms13302DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5114619PMC
November 2016

Enantioselective Synthesis of Polysubstituted Benzopyrano[3,4-c]pyrrolidine Frameworks via [3 + 2] Cycloaddition of Azomethine Ylides and Coumarin Derivatives.

J Org Chem 2016 10 4;81(20):10071-10080. Epub 2016 Oct 4.

Department of Chemistry, National Taiwan Normal University , Taipei 11677, Taiwan, R.O.C.

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http://dx.doi.org/10.1021/acs.joc.6b02041DOI Listing
October 2016

Transcriptional Profiling of Mycobacterium tuberculosis Exposed to In Vitro Lysosomal Stress.

Infect Immun 2016 Sep 19;84(9):2505-23. Epub 2016 Aug 19.

Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore Immunology Programme, Life Sciences Institute, National University of Singapore, Singapore Infectious Disease Interdisciplinary Research Group, Singapore-MIT Alliance for Research and Technology, Singapore

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http://dx.doi.org/10.1128/IAI.00072-16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4995911PMC
September 2016

Synthesis of Functionalized Furans via Chemoselective Reduction/Wittig Reaction Using Catalytic Triethylamine and Phosphine.

Org Lett 2016 08 19;18(15):3758-61. Epub 2016 Jul 19.

Department of Chemistry, National Taiwan Normal University , 88, Sec. 4, Tingchow Road, Taipei 11677, Taiwan ROC.

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http://dx.doi.org/10.1021/acs.orglett.6b01781DOI Listing
August 2016

Expanding the Scope of Primary Amine Catalysis: Stereoselective Synthesis of Indanedione-Fused 2,6-Disubstituted trans-Spirocyclohexanones.

J Org Chem 2016 Mar 1;81(6):2420-31. Epub 2016 Mar 1.

Department of Chemistry, National Taiwan Normal University , Taipei 11677, Taiwan, ROC.

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http://dx.doi.org/10.1021/acs.joc.5b02921DOI Listing
March 2016

Organocatalytic Enantioselective Synthesis of Tetrahydrofluoren-9-ones via Vinylogous Michael Addition/Henry Reaction Cascade of 1,3-Indandione-Derived Pronucleophiles.

Org Lett 2016 Feb 3;18(4):688-91. Epub 2016 Feb 3.

Department of Chemistry, National Taiwan Normal University , 88, Sec. 4, Tingchow Road, Taipei 11677, Taiwan, R.O.C.

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http://dx.doi.org/10.1021/acs.orglett.5b03663DOI Listing
February 2016

Development of CINPA1 analogs as novel and potent inverse agonists of constitutive androstane receptor.

Eur J Med Chem 2016 Jan 15;108:505-528. Epub 2015 Dec 15.

Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Mail Stop 1000, Memphis, TN 38105, United States. Electronic address:

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http://dx.doi.org/10.1016/j.ejmech.2015.12.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4724233PMC
January 2016

Serine 350 of human pregnane X receptor is crucial for its heterodimerization with retinoid X receptor alpha and transactivation of target genes in vitro and in vivo.

Biochem Pharmacol 2015 Aug 25;96(4):357-68. Epub 2015 Jun 25.

Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, TN 38105, USA; Integrated Biomedical Sciences Program, University of Tennessee Health Science Center, Memphis, TN 38163, USA. Electronic address:

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http://dx.doi.org/10.1016/j.bcp.2015.06.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4526351PMC
August 2015

Preparation of Furo[3,2-c]coumarins from 3-Cinnamoyl-4-hydroxy-2H-chromen-2-ones and Acyl Chlorides: A Bu3P-Mediated C-Acylation/Cyclization Sequence.

Angew Chem Int Ed Engl 2015 Jul 1;54(29):8502-5. Epub 2015 Jun 1.

Department of Chemistry, National Taiwan Normal University, 88, Sec. 4, Tingchow Road, Taipei 11677 (Taiwan, R.O.C.).

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http://dx.doi.org/10.1002/anie.201502789DOI Listing
July 2015

Absence of Annexin A1 impairs host adaptive immunity against Mycobacterium tuberculosis in vivo.

Immunobiology 2015 May 10;220(5):614-23. Epub 2014 Dec 10.

Department of Microbiology, Yong Loo Lin School of Medicine, Life Sciences Institute, National University of Singapore, Singapore; Immunology Programme, Yong Loo Lin School of Medicine, Life Sciences Institute, National University of Singapore, Singapore. Electronic address:

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http://dx.doi.org/10.1016/j.imbio.2014.12.001DOI Listing
May 2015

CINPA1 is an inhibitor of constitutive androstane receptor that does not activate pregnane X receptor.

Mol Pharmacol 2015 May 11;87(5):878-89. Epub 2015 Mar 11.

Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, Tennessee

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http://dx.doi.org/10.1124/mol.115.097782DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4407736PMC
May 2015

PRL-3 mediates the protein maturation of ULBP2 by regulating the tyrosine phosphorylation of HSP60.

J Immunol 2015 Mar 16;194(6):2930-41. Epub 2015 Feb 16.

Department of Bone Marrow Transplantation and Cellular Therapy, St. Jude Children's Research Hospital, Memphis, TN 38105; Department of Pediatrics, University of Tennessee Health Science Center, Memphis, TN 38103

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http://dx.doi.org/10.4049/jimmunol.1400817DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4355089PMC
March 2015

Organocatalytic enantioselective direct vinylogous Michael addition of α,β-unsaturated γ-butyrolactam to β-acyl acrylates and 1,2-diacylethylenes.

J Org Chem 2015 Feb 16;80(3):1985-92. Epub 2015 Jan 16.

Department of Chemistry, National Taiwan Normal University , Taipei 11677, Taiwan, Republic of China.

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http://dx.doi.org/10.1021/jo5027047DOI Listing
February 2015

A high-throughput screen reveals new small-molecule activators and inhibitors of pantothenate kinases.

J Med Chem 2015 Feb 21;58(3):1563-8. Epub 2015 Jan 21.

Department of Chemical Biology and Therapeutics, ‡Department of Infectious Diseases, St. Jude Children's Research Hospital , 262 Danny Thomas Place, Memphis, Tennessee 38105, United States.

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http://dx.doi.org/10.1021/jm501585qDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4357395PMC
February 2015

High-throughput screening reveals alsterpaullone, 2-cyanoethyl as a potent p27Kip1 transcriptional inhibitor.

PLoS One 2014 19;9(3):e91173. Epub 2014 Mar 19.

Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, Tennessee, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0091173PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3960108PMC
December 2014

Chemoselective intramolecular Wittig reactions for the synthesis of oxazoles and benzofurans.

J Org Chem 2014 Dec 24;79(23):11567-82. Epub 2014 Nov 24.

Department of Chemistry, National Taiwan Normal University , Taipei 11677, Taiwan, R.O.C.

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http://dx.doi.org/10.1021/jo502232qDOI Listing
December 2014

Development of BODIPY FL vindoline as a novel and high-affinity pregnane X receptor fluorescent probe.

Bioconjug Chem 2014 Sep 18;25(9):1664-77. Epub 2014 Aug 18.

Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital , 262 Danny Thomas Place, Mail Stop 1000, Memphis, Tennessee 38105, United States.

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http://dx.doi.org/10.1021/bc5002856DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4166032PMC
September 2014

Identification of trisubstituted-pyrazol carboxamide analogs as novel and potent antagonists of farnesoid X receptor.

Bioorg Med Chem 2014 Jun 16;22(11):2919-38. Epub 2014 Apr 16.

Department of Chemical Biology & Therapeutics, St. Jude Children's Research Hospital, Memphis, TN 38105, USA. Electronic address:

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http://dx.doi.org/10.1016/j.bmc.2014.04.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4147378PMC
June 2014

Preparation of functionalized heteroaromatics using an intramolecular Wittig reaction.

Org Biomol Chem 2014 Jun;12(24):4044-50

Department of Chemistry, National Taiwan Normal University, No. 88, Sec. 4, Tingchow Road, Taipei, Taiwan 11677, Republic of China.

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http://dx.doi.org/10.1039/c4ob00464gDOI Listing
June 2014

Direct β-acylation of 2-arylidene-1,3-indandiones with acyl chlorides catalyzed by organophosphanes.

Chem Commun (Camb) 2014 May 14;50(40):5304-6. Epub 2013 Aug 14.

Department of Chemistry, National Taiwan Normal University, 88, Sec. 4, Tingchow Road, Taipei 11677, Taiwan, Republic of China.

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http://xlink.rsc.org/?DOI=C3CC45201H
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http://dx.doi.org/10.1039/c3cc45201hDOI Listing
May 2014

Tyrosine phosphorylation of protein kinase complex BAK1/BIK1 mediates Arabidopsis innate immunity.

Proc Natl Acad Sci U S A 2014 Mar 14;111(9):3632-7. Epub 2014 Feb 14.

Departments of Plant Pathology and Microbiology and Biochemistry and Biophysics, Institute for Plant Genomics and Biotechnology, Texas A&M University, College Station, TX 77843.

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http://dx.doi.org/10.1073/pnas.1318817111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3948311PMC
March 2014

Role of the CD137 ligand (CD137L) signaling pathway during Mycobacterium tuberculosis infection.

Immunobiology 2014 Jan 23;219(1):78-86. Epub 2013 Aug 23.

Department of Microbiology, Yong Loo Lin School of Medicine, Life Sciences Institute, National University of Singapore, Singapore; Immunology Programme, Yong Loo Lin School of Medicine, Life Sciences Institute, National University of Singapore, Singapore.

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http://dx.doi.org/10.1016/j.imbio.2013.08.009DOI Listing
January 2014

Big roles of small kinases: the complex functions of receptor-like cytoplasmic kinases in plant immunity and development.

J Integr Plant Biol 2013 Dec 18;55(12):1188-97. Epub 2013 Sep 18.

Department of Plant Pathology and Microbiology, and Institute for Plant Genomics and Biotechnology, Texas A&M University, College Station, Texas, 77843, USA.

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http://dx.doi.org/10.1111/jipb.12071DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4391744PMC
December 2013

A vinblastine fluorescent probe for pregnane X receptor in a time-resolved fluorescence resonance energy transfer assay.

Anal Biochem 2013 Dec 14;443(2):252-60. Epub 2013 Sep 14.

Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.

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http://dx.doi.org/10.1016/j.ab.2013.09.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3825844PMC
December 2013

An efficient synthesis of trisubstituted oxazoles via chemoselective O-acylations and intramolecular Wittig reactions.

Chem Commun (Camb) 2013 Nov;49(87):10266-8

Department of Chemistry, National Taiwan Normal University, 88, Sec. 4, Tingchow Road, Taipei 11677, Taiwan, Republic of China.

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http://dx.doi.org/10.1039/c3cc45883kDOI Listing
November 2013

Modulation of NKG2D ligand expression and metastasis in tumors by spironolactone via RXRγ activation.

J Exp Med 2013 Nov 4;210(12):2675-92. Epub 2013 Nov 4.

Department of Bone Marrow Transplantation and Cellular Therapy; 2 Department of Chemical Biology & Therapeutics; and 3 Department of Pathology, St. Jude Children's Research Hospital, Memphis, Tennessee 38105.

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http://dx.doi.org/10.1084/jem.20122292DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3832934PMC
November 2013

Piperine activates human pregnane X receptor to induce the expression of cytochrome P450 3A4 and multidrug resistance protein 1.

Toxicol Appl Pharmacol 2013 Oct 22;272(1):96-107. Epub 2013 May 22.

Department of Chemical Biology & Therapeutics, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA.

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http://dx.doi.org/10.1016/j.taap.2013.05.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3775940PMC
October 2013

Chemoselective synthesis of tetrasubstituted furans via intramolecular Wittig reactions: mechanism and theoretical analysis.

Org Biomol Chem 2013 Aug 2;11(31):5156-61. Epub 2013 Jul 2.

Department of Chemistry, National Taiwan Normal University, 88, Sec. 4, Tingchow Road, Taipei 11677, Taiwan, ROC.

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http://dx.doi.org/10.1039/c3ob40858bDOI Listing
August 2013

Development of time resolved fluorescence resonance energy transfer-based assay for FXR antagonist discovery.

Bioorg Med Chem 2013 Jul 7;21(14):4266-78. Epub 2013 May 7.

Department of Diabetes, Endocrinology and Metabolism, Beckman Research Institute, City of Hope National Medical Center, Duarte, CA 91010, USA.

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http://dx.doi.org/10.1016/j.bmc.2013.04.069DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3691817PMC
July 2013

Inverse modulation of plant immune and brassinosteroid signaling pathways by the receptor-like cytoplasmic kinase BIK1.

Proc Natl Acad Sci U S A 2013 Jul 1;110(29):12114-9. Epub 2013 Jul 1.

Key Laboratory of Biopesticide and Chemical Biology, Ministry of Education, Fujian Agriculture and Forestry University, Fuzhou 350002, China.

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http://dx.doi.org/10.1073/pnas.1302154110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3718091PMC
July 2013

Organocatalytic enantioselective direct vinylogous Michael addition of γ-substituted butenolides to 3-aroyl acrylates and 1,2-diaroylethylenes.

Chemistry 2013 Jun 6;19(24):7713-7. Epub 2013 May 6.

Department of Chemistry, National Taiwan Normal University, 88, Sec. 4, Tingchow Road, Taipei 11677, Taiwan, ROC.

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http://dx.doi.org/10.1002/chem.201301332DOI Listing
June 2013

A versatile and practical method for regioselective synthesis of polysubstituted furanonaphthoquinones.

Org Biomol Chem 2013 Feb 12;11(5):828-34. Epub 2012 Dec 12.

Department of Chemistry, National Taiwan Normal University, 88, Sec. 4, Tingchow Road, Taipei 11677, Taiwan, ROC.

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http://dx.doi.org/10.1039/c2ob26986dDOI Listing
February 2013

An efficient organocatalytic enantioselective synthesis of spironitrocyclopropanes.

Org Biomol Chem 2013 Jan;11(1):44-7

Department of Chemistry, National Taiwan Normal University, 88, Section 4, Tingchow Road, Taipei 11677, Taiwan, ROC.

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http://dx.doi.org/10.1039/c2ob26943kDOI Listing
January 2013

Bifurcation of Arabidopsis NLR immune signaling via Ca²⁺-dependent protein kinases.

PLoS Pathog 2013 Jan 31;9(1):e1003127. Epub 2013 Jan 31.

Department of Biochemistry and Biophysics, and Institute for Plant Genomics and Biotechnology, Texas A&M University, College Station, Texas, United States of America.

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http://dx.plos.org/10.1371/journal.ppat.1003127
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http://dx.doi.org/10.1371/journal.ppat.1003127DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3561149PMC
January 2013

Enantioselective organocatalytic Michael addition of ketones to alkylidene malonates.

Chirality 2012 Aug 16;24(8):600-5. Epub 2012 May 16.

Department of Chemistry, National Taiwan Normal University, Taipei, Republic of China.

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http://dx.doi.org/10.1002/chir.22055DOI Listing
August 2012

Urease activity represents an alternative pathway for Mycobacterium tuberculosis nitrogen metabolism.

Infect Immun 2012 Aug 29;80(8):2771-9. Epub 2012 May 29.

Department of Microbiology, Immunology Programme, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.

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http://dx.doi.org/10.1128/IAI.06195-11DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3434571PMC
August 2012

Preparation of functional benzofurans and indoles via chemoselective intramolecular Wittig reactions.

Chem Commun (Camb) 2012 Aug 9;48(65):8135-7. Epub 2012 Jul 9.

Department of Chemistry, National Taiwan Normal University, 88, Sec. 4, Tingchow Road, Taipei 11677, Taiwan, ROC.

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http://dx.doi.org/10.1039/c2cc33972bDOI Listing
August 2012

Enantioselective synthesis of substituted pyrans via amine-catalyzed Michael addition and subsequent enolization/cyclisation.

Chem Commun (Camb) 2012 Jun 24;48(45):5590-2. Epub 2012 Apr 24.

Department of Chemistry, National Taiwan Normal University, 88, Sec. 4, Tingchow Road, Taipei 11677, Taiwan, ROC.

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http://dx.doi.org/10.1039/c2cc31445bDOI Listing
June 2012

Preparation of functional phosphorus zwitterions from activated alkanes, aldehydes, and tributylphosphine: synthesis of polysubstituted furo[3,2-c]coumarins.

Org Lett 2012 Apr 21;14(7):1906-9. Epub 2012 Mar 21.

Department of Chemistry, National Taiwan Normal University, 88, Section 4, Tingchow Road, Taipei 11677, Taiwan, ROC.

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http://dx.doi.org/10.1021/ol3005479DOI Listing
April 2012

Tandem three-component reactions of aldehyde, alkyl acrylate, and dialkylmalonate catalyzed by ethyl diphenylphosphine.

Molecules 2012 Mar 2;17(3):2529-41. Epub 2012 Mar 2.

Department of Chemistry, National Taiwan Normal University No. 88, Section 4, Tingchow Road, Taipei 11677, Taiwan.

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http://dx.doi.org/10.3390/molecules17032529DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6268679PMC
March 2012

Syntheses of furo[3,4-c]coumarins and related furyl coumarin derivatives via intramolecular Wittig reactions.

Org Biomol Chem 2012 Jan 1;10(4):843-7. Epub 2011 Dec 1.

Department of Chemistry, National Taiwan Normal University, Taipei, Taiwan, Republic of China.

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http://dx.doi.org/10.1039/c1ob06571hDOI Listing
January 2012

A tea catechin, epigallocatechin-3-gallate, is a unique modulator of the farnesoid X receptor.

Toxicol Appl Pharmacol 2012 Jan 4;258(2):268-74. Epub 2011 Dec 4.

Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, Kansas City, KS 66160, USA.

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http://dx.doi.org/10.1016/j.taap.2011.11.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3259191PMC
January 2012

Development of a pterin-based fluorescent probe for screening dihydropteroate synthase.

Bioconjug Chem 2011 Oct 30;22(10):2110-7. Epub 2011 Sep 30.

Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, United States.

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http://dx.doi.org/10.1021/bc200346eDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3384522PMC
October 2011

Design, synthesis, and evaluation of 2-diethanolamino-4,8-diheptamethyleneimino-2-(N-aminoethyl-N-ethanolamino)-6-(N,N-diethanolamino)pyrimido[5,4-d]pyrimidine-fluorescein conjugate (8MDP-fluor), as a novel equilibrative nucleoside transporter probe.

Bioconjug Chem 2011 Jun 13;22(6):1221-7. Epub 2011 May 13.

Department of Pharmaceutical Sciences, College of Pharmacy, University of Tennessee Health Sciences Center, Memphis, Tennessee 38163, United States.

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http://dx.doi.org/10.1021/bc2000758DOI Listing
June 2011

Preparation of functional benzofurans, benzothiophenes, and indoles using ester, thioester, and amide via intramolecular Wittig reactions.

Org Lett 2011 Jun 12;13(11):2970-3. Epub 2011 May 12.

Department of Chemistry, National Taiwan Normal University, Taipei, Taiwan, ROC.

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http://dx.doi.org/10.1021/ol201062rDOI Listing
June 2011

Direct ubiquitination of pattern recognition receptor FLS2 attenuates plant innate immunity.

Science 2011 Jun;332(6036):1439-42

Department of Biochemistry and Biophysics, Texas A&M University, College Station, TX 77843, USA.

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http://dx.doi.org/10.1126/science.1204903DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3243913PMC
June 2011

Identification of N6,N6-dimethyladenosine in transfer RNA from Mycobacterium bovis Bacille Calmette-Guérin.

Molecules 2011 Jun 21;16(6):5168-81. Epub 2011 Jun 21.

Department of Chemistry, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA.

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http://dx.doi.org/10.3390/molecules16065168DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6264175PMC
June 2011

A facile approach to highly functional trisubstituted furans via intramolecular Wittig reactions.

Org Biomol Chem 2011 Apr 1;9(7):2098-106. Epub 2011 Feb 1.

Department of Chemistry, National Taiwan Normal University, 88, Section 4, Tingchow Road, Taipei 11677, Taiwan, Republic of China.

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http://dx.doi.org/10.1039/c0ob00912aDOI Listing
April 2011

Organocatalytic tandem three-component reaction of imine, alkyl vinyl ketone, and imide via aza-Baylis-Hillman reaction.

J Org Chem 2011 Apr 14;76(8):2888-91. Epub 2011 Mar 14.

Department of Chemistry, National Taiwan Normal University, 88, Section 4, Tingchow Road, Taipei 11677, Taiwan, Republic of China.

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http://dx.doi.org/10.1021/jo102143rDOI Listing
April 2011

Organocatalytic tandem three-component reaction of aldehyde, alkyl vinyl ketone, and amide: one-pot syntheses of highly functional alkenes.

Org Biomol Chem 2011 Jan 4;9(2):363-6. Epub 2010 Nov 4.

Department of Chemistry, National Taiwan Normal University, 88, Section 4, Tingchow Road, Taipei 11677, Taiwan, ROC.

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http://dx.doi.org/10.1039/c0ob00644kDOI Listing
January 2011

Preparation of tetrasubstituted furans via intramolecular Wittig reactions with phosphorus ylides as intermediates.

Org Lett 2010 Jul;12(13):3066-9

Department of Chemistry, National Taiwan Normal University, 88, Section 4, Tingchow Road, Taipei 11677, Taiwan, Republic of China.

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http://dx.doi.org/10.1021/ol101080qDOI Listing
July 2010

Flavonoids activate pregnane x receptor-mediated CYP3A4 gene expression by inhibiting cyclin-dependent kinases in HepG2 liver carcinoma cells.

BMC Biochem 2010 Jun 16;11:23. Epub 2010 Jun 16.

Department of Chemical Biology and Therapeutics, St, Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA.

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http://dx.doi.org/10.1186/1471-2091-11-23DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2901217PMC
June 2010

Cyclin-dependent kinase 2 negatively regulates human pregnane X receptor-mediated CYP3A4 gene expression in HepG2 liver carcinoma cells.

J Biol Chem 2008 Nov 9;283(45):30650-7. Epub 2008 Sep 9.

Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, USA.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M806132200
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http://dx.doi.org/10.1074/jbc.M806132200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2662154PMC
November 2008