Wenwei Hu

Wenwei Hu

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Wenwei Hu

Publications by authors named "Wenwei Hu"

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Association of KRAS mutation with tumor deposit status and overall survival of colorectal cancer.

Cancer Causes Control 2020 Jul 11;31(7):683-689. Epub 2020 May 11.

Rutgers Cancer Institute of New Jersey, New Brunswick, NJ, USA.

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http://dx.doi.org/10.1007/s10552-020-01313-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7319095PMC
July 2020

Gain of function mutant p53 protein activates AKT through the Rac1 signaling to promote tumorigenesis.

Cell Cycle 2020 Jun 10;19(11):1338-1351. Epub 2020 Apr 10.

Rutgers Cancer Institute of New Jersey; Rutgers University , New Brunswick, NJ, USA.

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http://dx.doi.org/10.1080/15384101.2020.1749790DOI Listing
June 2020

Autophagy promotes mammalian survival by suppressing oxidative stress and p53.

Genes Dev 2020 May 19;34(9-10):688-700. Epub 2020 Mar 19.

Rutgers Cancer Institute of New Jersey, New Brunswick, New Jersey 08903, USA.

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http://dx.doi.org/10.1101/gad.335570.119DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7197357PMC
May 2020

Visible-Light-Triggered Quantitative Oxidation of 9,10-Dihydroanthracene to Anthraquinone by O under Mild Conditions.

ChemSusChem 2020 Apr 28;13(7):1785-1792. Epub 2020 Feb 28.

National and Local Joint Engineering Laboratory for New Petro-chemical Materials and Fine Utilization of Resources, College of Chemistry and Chemical Engineering, Hunan Normal University, Changsha, Hunan, 410081, P.R. China.

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http://dx.doi.org/10.1002/cssc.201903549DOI Listing
April 2020

The Identification and Analysis of mRNA-lncRNA-miRNA Cliques From the Integrative Network of Ovarian Cancer.

Front Genet 2019 21;10:751. Epub 2019 Aug 21.

Department of Tumor Biological Treatment, The Third Affiliated Hospital of Soochow University, Changzhou, China.

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http://dx.doi.org/10.3389/fgene.2019.00751DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6712160PMC
August 2019

Prognostic significance of resident CD103CD8T cells in human colorectal cancer tissues.

Acta Histochem 2019 Jul 30;121(5):657-663. Epub 2019 May 30.

Department of Tumor Biological Treatment, The Third Affiliated Hospital of Soochow University, Changzhou, China; Jiangsu Engineering Research Center for Tumor Immunotherapy, The Third Affiliated Hospital of Soochow University, Changzhou, China; Institute of Cell Therapy, The Third Affiliated Hospital of Soochow University, Changzhou, China. Electronic address:

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http://dx.doi.org/10.1016/j.acthis.2019.05.009DOI Listing
July 2019

The role of p53 in reproduction, an unexpected function for a tumor suppressor.

J Mol Cell Biol 2019 07;11(7):624-627

Rutgers Cancer Institute of New Jersey, Rutgers University, New Brunswick, NJ 08903, USA.

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http://dx.doi.org/10.1093/jmcb/mjz072DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6735926PMC
July 2019

Hsa_circ_0009361 acts as the sponge of miR-582 to suppress colorectal cancer progression by regulating APC2 expression.

Clin Sci (Lond) 2019 05 30;133(10):1197-1213. Epub 2019 May 30.

Jiangsu Engineering Research Center for Tumor Immunotherapy, Changzhou 213003, People's Republic of China

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http://www.clinsci.org/lookup/doi/10.1042/CS20190286
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http://dx.doi.org/10.1042/CS20190286DOI Listing
May 2019

Tumor suppressor p53 and metabolism.

J Mol Cell Biol 2019 04;11(4):284-292

Department of Radiation Oncology, Rutgers Cancer Institute of New Jersey, Rutgers University, State University of New Jersey, New Brunswick, NJ, USA.

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http://dx.doi.org/10.1093/jmcb/mjy070DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6487777PMC
April 2019

miR-183-5p Inhibits Occurrence and Progression of Acute Myeloid Leukemia via Targeting Erbin.

Mol Ther 2019 03 1;27(3):542-558. Epub 2019 Feb 1.

Department of Tumor Biological Treatment, The Third Affiliated Hospital of Soochow University, Changzhou, Jiangsu Province, China; Cancer Immunotherapy Engineering Research Center of Jiangsu Province, Changzhou, Jiangsu Province, China; Institute of Cell Therapy, Soochow University, Changzhou, Jiangsu Province, China. Electronic address:

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http://dx.doi.org/10.1016/j.ymthe.2019.01.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6401194PMC
March 2019

A novel protein encoded by a circular RNA circPPP1R12A promotes tumor pathogenesis and metastasis of colon cancer via Hippo-YAP signaling.

Mol Cancer 2019 03 29;18(1):47. Epub 2019 Mar 29.

Department of Tumor Biological Treatment, the Third Affiliated Hospital of Soochow University, Changzhou, 213003, People's Republic of China.

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http://dx.doi.org/10.1186/s12943-019-1010-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6440158PMC
March 2019

IL-1β-Mediated Up-Regulation of WT1D via miR-144-3p and Their Synergistic Effect with NF-κB/COX-2/HIF-1α Pathway on Cell Proliferation in LUAD.

Cell Physiol Biochem 2018 17;48(6):2493-2502. Epub 2018 Aug 17.

Department of Oncology, the Third Affiliated Hospital of Soochow University, Changzhou, China.

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http://dx.doi.org/10.1159/000492687DOI Listing
September 2018

Parkinson's disease-associated protein Parkin: an unusual player in cancer.

Cancer Commun (Lond) 2018 06 26;38(1):40. Epub 2018 Jun 26.

Department of Radiation Oncology, Rutgers Cancer Institute of New Jersey, Rutgers, State University of New Jersey, New Brunswick, NJ, 08903, USA.

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http://dx.doi.org/10.1186/s40880-018-0314-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6020249PMC
June 2018

Prognostic Role of Tumor-Infiltrating Lymphocytes in Esophagus Cancer: a Meta-Analysis.

Cell Physiol Biochem 2018 31;45(2):720-732. Epub 2018 Jan 31.

Department of Tumor Biological Treatment, The Third Affiliated Hospital of Soochow University, Changzhou, China.

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http://dx.doi.org/10.1159/000487164DOI Listing
March 2018

A polymorphism in the tumor suppressor p53 affects aging and longevity in mouse models.

Elife 2018 03 20;7. Epub 2018 Mar 20.

Department of Radiation Oncology, Rutgers Cancer Institute of New Jersey, Robert Wood Johnson Medical School, Rutgers, the State University of New Jersey, New Brunswick, United States.

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http://dx.doi.org/10.7554/eLife.34701DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5906094PMC
March 2018

Inhibition of HIV early replication by the p53 and its downstream gene p21.

Virol J 2018 03 27;15(1):53. Epub 2018 Mar 27.

Center for Immunology and Microbial Disease, Albany Medical College, Albany, New York, Albany, NY, 12208, USA.

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http://dx.doi.org/10.1186/s12985-018-0959-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5870690PMC
March 2018

Lycorine Promotes Autophagy and Apoptosis via TCRP1/Akt/mTOR Axis Inactivation in Human Hepatocellular Carcinoma.

Mol Cancer Ther 2017 Dec 28;16(12):2711-2723. Epub 2017 Sep 28.

Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, China.

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http://dx.doi.org/10.1158/1535-7163.MCT-17-0498DOI Listing
December 2017

Parkin targets HIF-1α for ubiquitination and degradation to inhibit breast tumor progression.

Nat Commun 2017 11 28;8(1):1823. Epub 2017 Nov 28.

Rutgers Cancer Institute of New Jersey, Robert Wood Johnson Medical School, Rutgers, State University of New Jersey, New Brunswick, NJ, 08903, USA.

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http://dx.doi.org/10.1038/s41467-017-01947-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5703960PMC
November 2017

MiR-629 promotes human pancreatic cancer progression by targeting FOXO3.

Cell Death Dis 2017 10 26;8(10):e3154. Epub 2017 Oct 26.

Department of Oncology, The Third Affiliated Hospital of Soochow University, Changzhou 213003, P.R. China.

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http://dx.doi.org/10.1038/cddis.2017.525DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5682687PMC
October 2017

Impact of marital status during diagnosis on cancer-caused specific survival in acute myeloid leukemia patients: a case-control and population-based study.

Oncotarget 2017 Sep 9;8(37):62666-62680. Epub 2017 Apr 9.

Department of Tumor Biological Treatment, The Third Affiliated Hospital of Soochow University, Changzhou, China.

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http://dx.doi.org/10.18632/oncotarget.16989DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5617539PMC
September 2017

The impact of p53 on the early stage replication of retrovirus.

Virol J 2017 08 9;14(1):151. Epub 2017 Aug 9.

Department of Basic and Clinical Sciences, Albany College of Pharmacy and Health Sciences, 106 New Scotland Ave, Albany, NY, 12208, USA.

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http://virologyj.biomedcentral.com/articles/10.1186/s12985-0
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http://dx.doi.org/10.1186/s12985-017-0820-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5550995PMC
August 2017

Prognostic role of tumor-infiltrating lymphocytes in gastric cancer: a meta-analysis.

Oncotarget 2017 Aug 22;8(34):57386-57398. Epub 2017 May 22.

Department of Tumor Biological Treatment, The Third Affiliated Hospital of Soochow University, Changzhou 213003, People's Republic of China.

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http://dx.doi.org/10.18632/oncotarget.18065DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5593650PMC
August 2017

Gain-of-function mutant p53 activates small GTPase Rac1 through SUMOylation to promote tumor progression.

Genes Dev 2017 08;31(16):1641-1654

Rutgers Cancer Institute of New Jersey, the State University of New Jersey, New Brunswick, New Jersey 08903, USA.

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http://dx.doi.org/10.1101/gad.301564.117DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5647935PMC
August 2017

Interleukin-33 Expression does not Correlate with Survival of Gastric Cancer Patients.

Pathol Oncol Res 2017 Jul 20;23(3):615-619. Epub 2016 Dec 20.

Department of Oncology, The Third Affiliated Hospital of Soochow University, Changzhou, Jiangsu Province, China.

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http://dx.doi.org/10.1007/s12253-016-0167-1DOI Listing
July 2017

Mutant p53 in Cancer: Accumulation, Gain-of-Function, and Therapy.

J Mol Biol 2017 06 6;429(11):1595-1606. Epub 2017 Apr 6.

Rutgers Cancer Institute of New Jersey, Rutgers, the State University of New Jersey, New Brunswick, NJ 08903, USA; Department of Pharmacology, Rutgers, the State University of New Jersey, New Brunswick, NJ 08903, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jmb.2017.03.030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5663274PMC
June 2017

Post surgery circulating free tumor DNA is a predictive biomarker for relapse of lung cancer.

Cancer Med 2017 May 5;6(5):962-974. Epub 2017 Apr 5.

School of Life Sciences and Technology, Tongji University, Shanghai, China.

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http://dx.doi.org/10.1002/cam4.980DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5430107PMC
May 2017

Serum IL-33 level is a predictor of progression-free survival after chemotherapy.

Oncotarget 2017 May;8(21):35116-35123

Department of Oncology, The Third Affiliated Hospital of Soochow University, Changzhou, Jiangsu Province, China.

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http://dx.doi.org/10.18632/oncotarget.16627DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5471039PMC
May 2017

Lower Bmi-1 Expression May Predict Longer Survival of Colon Cancer Patients.

Cell Physiol Biochem 2016 11;39(6):2421-2426. Epub 2016 Nov 11.

Department of Oncology, The Third Affiliated Hospital of Soochow University, Changzhou, (P. R. China).

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http://dx.doi.org/10.1159/000452510DOI Listing
February 2017

Identification, validation, and targeting of the mutant p53-PARP-MCM chromatin axis in triple negative breast cancer.

NPJ Breast Cancer 2017 19;3. Epub 2017 Jan 19.

The Department of Biological Sciences Hunter College, City University of New York, Hunter College-Weill Cornell Belfer Research Building, 413 East 69th, New York, NY 10065, USA; The Graduate Center PhD Programs in Biology and Biochemistry, City University of New York, New York, NY 10016, USA; Department of Cell and Developmental Biology, Weill Cornell Medical College of Cornell University, New York, NY 10065, USA.

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http://dx.doi.org/10.1038/s41523-016-0001-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5319483PMC
January 2017

A novel mutant p53 binding partner BAG5 stabilizes mutant p53 and promotes mutant p53 GOFs in tumorigenesis.

Cell Discov 2016 1;2:16039. Epub 2016 Nov 1.

Department of Radiation Oncology, Rutgers Cancer Institute of New Jersey, Rutgers the State University of New Jersey, New Brunswick, NJ, USA; Department of Pharmacology, Rutgers the State University of New Jersey, New Brunswick, NJ, USA.

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http://dx.doi.org/10.1038/celldisc.2016.39DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5088412PMC
November 2016

Cullin3-KLHL25 ubiquitin ligase targets ACLY for degradation to inhibit lipid synthesis and tumor progression.

Genes Dev 2016 Sep;30(17):1956-70

Department of Radiation Oncology, Rutgers Cancer Institute of New Jersey, Rutgers University, The State University of New Jersey, New Brunswick, New Jersey 08903, USA; Department of Pharmacology, Rutgers University, The State University of New Jersey, Piscataway, New Jersey 08854, USA.

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http://dx.doi.org/10.1101/gad.283283.116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5066239PMC
September 2016

TRIM32 is a novel negative regulator of p53.

Mol Cell Oncol 2015 Apr-Jun;2(2):e970951. Epub 2014 Dec 1.

Department of Radiation Oncology; Rutgers Cancer Institute of New Jersey; Rutgers, State University of New Jersey ; New Brunswick, NJ USA.

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http://dx.doi.org/10.4161/23723548.2014.970951DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4904883PMC
June 2016

Pontin, a novel interactor of mutant p53 that promotes mutant p53 gain of function.

Mol Cell Oncol 2016 Mar 29;3(2):e1076587. Epub 2015 Jul 29.

Rutgers Cancer Institute of New Jersey, Rutgers the State University of New Jersey , New Brunswick, NJ, USA.

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http://dx.doi.org/10.1080/23723556.2015.1076587DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905376PMC
March 2016

microRNA-1827 represses MDM2 to positively regulate tumor suppressor p53 and suppress tumorigenesis.

Oncotarget 2016 Feb;7(8):8783-96

Department of Radiation Oncology, Rutgers Cancer Institute of New Jersey, Rutgers, State University of New Jersey, New Brunswick, NJ 08903, USA.

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http://dx.doi.org/10.18632/oncotarget.7088DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4891004PMC
February 2016

Leukemia inhibitory factor promotes EMT through STAT3-dependent miR-21 induction.

Oncotarget 2016 Jan;7(4):3777-90

Department of Radiation Oncology, Rutgers Cancer Institute of New Jersey, Rutgers State University of New Jersey, New Brunswick, NJ, USA.

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http://www.oncotarget.com/fulltext/6756
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http://dx.doi.org/10.18632/oncotarget.6756DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4826169PMC
January 2016

Glutaminase 2 is a novel negative regulator of small GTPase Rac1 and mediates p53 function in suppressing metastasis.

Elife 2016 Jan 11;5:e10727. Epub 2016 Jan 11.

Department of Radiation Oncology, Rutgers Cancer Institute of New Jersey, Rutgers, The State University of New Jersey, New Brunswick, United States.

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http://dx.doi.org/10.7554/eLife.10727DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4749555PMC
January 2016

Emerging immune checkpoints for cancer therapy.

Acta Oncol 2015 Nov 11;54(10):1706-13. Epub 2015 Sep 11.

a Department of Oncology , The Third Affiliated Hospital of Soochow University , Changzhou , China.

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http://dx.doi.org/10.3109/0284186X.2015.1071918DOI Listing
November 2015

HIF-2α mediates hypoxia-induced LIF expression in human colorectal cancer cells.

Oncotarget 2015 Feb;6(6):4406-17

Rutgers Cancer Institute of New Jersey, Rutgers the State University of New Jersey, New Brunswick, NJ, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4414199PMC
http://dx.doi.org/10.18632/oncotarget.3017DOI Listing
February 2015

Tumor suppressor p53 and its mutants in cancer metabolism.

Cancer Lett 2015 Jan 24;356(2 Pt A):197-203. Epub 2013 Dec 24.

Department of Radiation Oncology, Rutgers Cancer Institute of New Jersey, Rutgers, The State University of New Jersey, New Brunswick, NJ 08903, USA. Electronic address:

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http://dx.doi.org/10.1016/j.canlet.2013.12.025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4069248PMC
January 2015

LIF is a new p53 negative regulator.

J Nat Sci 2015;1(7):e131

Department of Radiation Oncology, Rutgers Cancer Institute of New Jersey, Rutgers, State University of New Jersey, New Brunswick, NJ, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4493903PMC
January 2015

The regulation of leukemia inhibitory factor.

Cancer Cell Microenviron 2015;2(3)

Rutgers Cancer Institute of New Jersey, Rutgers the State University of New Jersey, New Brunswick, NJ USA.

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http://dx.doi.org/10.14800/ccm.877DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4722946PMC
January 2015

Multicenter phase II study of apatinib in non-triple-negative metastatic breast cancer.

BMC Cancer 2014 Nov 7;14:820. Epub 2014 Nov 7.

Department of Medical Oncology, Fudan University Cancer Hospital, Shanghai Medical School, Shanghai, China.

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http://dx.doi.org/10.1186/1471-2407-14-820DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4237755PMC
November 2014

LIF negatively regulates tumour-suppressor p53 through Stat3/ID1/MDM2 in colorectal cancers.

Nat Commun 2014 Oct 17;5:5218. Epub 2014 Oct 17.

Rutgers Cancer Institute of New Jersey, Rutgers, the State University of New Jersey, New Brunswick, New Jersey 08903, USA.

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http://dx.doi.org/10.1038/ncomms6218DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4203416PMC
October 2014

Tumour-associated mutant p53 drives the Warburg effect.

Nat Commun 2013 ;4:2935

Department of Radiation Oncology, Rutgers Cancer Institute of New Jersey, Rutgers State University of New Jersey, New Brunswick, New Jersey 08902, USA.

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http://dx.doi.org/10.1038/ncomms3935DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3969270PMC
July 2014

Spliced MDM2 isoforms promote mutant p53 accumulation and gain-of-function in tumorigenesis.

Nat Commun 2013 ;4:2996

Department of Pediatrics, Rutgers Cancer Institute of New Jersey, Rutgers State University of New Jersey, New Brunswick, NJ 08903, USA.

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http://dx.doi.org/10.1038/ncomms3996DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3960723PMC
July 2014

Tumor suppressor p53 negatively regulates glycolysis stimulated by hypoxia through its target RRAD.

Oncotarget 2014 Jul;5(14):5535-46

Department of Radiation Oncology, Rutgers Cancer Institute of New Jersey, Rutgers, State University of New Jersey, New Brunswick, USA.

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http://www.oncotarget.com/fulltext/2137
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4170611PMC
http://dx.doi.org/10.18632/oncotarget.2137DOI Listing
July 2014

The regulation of MDM2 oncogene and its impact on human cancers.

Acta Biochim Biophys Sin (Shanghai) 2014 Mar 3;46(3):180-9. Epub 2014 Jan 3.

Rutgers Cancer Institute of New Jersey, Rutgers the State University of New Jersey, New Brunswick, NJ 08903, USA.

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http://dx.doi.org/10.1093/abbs/gmt147DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3932834PMC
March 2014

A genetic variant in p63 (rs17506395) is associated with breast cancer susceptibility and prognosis.

Gene 2014 Feb 4;535(2):170-6. Epub 2013 Dec 4.

Department of Breast Surgery, Qilu Hospital, Shandong University, Shandong, China; Key Laboratory of Experimental Teratology, Ministry of Education and Institute of Molecular Medicine and Genetics, Shandong University School of Medicine, Jinan, China. Electronic address:

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http://dx.doi.org/10.1016/j.gene.2013.11.038DOI Listing
February 2014

LIF promotes tumorigenesis and metastasis of breast cancer through the AKT-mTOR pathway.

Oncotarget 2014 Feb;5(3):788-801

Department of Radiation Oncology, Rutgers Cancer Institute of New Jersey, Rutgers State University of New Jersey, New Brunswick, NJ, USA.

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http://www.oncotarget.com/fulltext/1772
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3996668PMC
http://dx.doi.org/10.18632/oncotarget.1772DOI Listing
February 2014

Multiple roles of p53-related pathways in somatic cell reprogramming and stem cell differentiation.

Cancer Res 2012 Nov 10;72(21):5635-45. Epub 2012 Sep 10.

The Cancer Institute of New Jersey, Institute for Advanced Study, Princeton, New Jersey 08540, USA.

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http://cancerres.aacrjournals.org/content/72/21/5635.full.pd
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http://cancerres.aacrjournals.org/cgi/doi/10.1158/0008-5472.
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http://dx.doi.org/10.1158/0008-5472.CAN-12-1451DOI Listing
November 2012

Metadherin mediates lipopolysaccharide-induced migration and invasion of breast cancer cells.

PLoS One 2011 16;6(12):e29363. Epub 2011 Dec 16.

Department of Breast Surgery, Shandong University School of Medicine, Jinan, Shandong, China.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0029363PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3241708PMC
August 2012

Chronic restraint stress attenuates p53 function and promotes tumorigenesis.

Proc Natl Acad Sci U S A 2012 May 16;109(18):7013-8. Epub 2012 Apr 16.

Department of Radiation Oncology and Department of Pediatrics, Cancer Institute of New Jersey, University of Medicine and Dentistry of New Jersey, New Brunswick, NJ 08903, USA.

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http://dx.doi.org/10.1073/pnas.1203930109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3345015PMC
May 2012

The Regulation of Multiple p53 Stress Responses is Mediated through MDM2.

Genes Cancer 2012 Mar;3(3-4):199-208

Cancer Institute of New Jersey, University of Medicine and Dentistry of New Jersey, New Brunswick, NJ, USA.

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http://dx.doi.org/10.1177/1947601912454734DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3494373PMC
March 2012

TAp63γ enhances nucleotide excision repair through transcriptional regulation of DNA repair genes.

DNA Repair (Amst) 2012 Feb 6;11(2):167-76. Epub 2011 Nov 6.

Cancer Institute of New Jersey, University of Medicine and Dentistry of New Jersey, New Brunswick, NJ 08903, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S156878641100311
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http://dx.doi.org/10.1016/j.dnarep.2011.10.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3348579PMC
February 2012

Acrolein induced DNA damage, mutagenicity and effect on DNA repair.

Mol Nutr Food Res 2011 Sep 29;55(9):1291-300. Epub 2011 Jun 29.

Department of Environmental Medicine, New York University School of Medicine, Tuxedo Park, NY 10967, USA.

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http://dx.doi.org/10.1002/mnfr.201100148DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4606864PMC
September 2011

Parkin, a p53 target gene, mediates the role of p53 in glucose metabolism and the Warburg effect.

Proc Natl Acad Sci U S A 2011 Sep 19;108(39):16259-64. Epub 2011 Sep 19.

Department of Radiation Oncology and Department of Pediatrics, Cancer Institute of New Jersey, University of Medicine and Dentistry of New Jersey, New Brunswick, NJ 08903, USA.

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http://dx.doi.org/10.1073/pnas.1113884108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3182683PMC
September 2011

Regulation of female reproduction by p53 and its family members.

FASEB J 2011 Jul 14;25(7):2245-55. Epub 2011 Mar 14.

Cancer Institute of New Jersey, University of Medicine and Dentistry of New Jersey, New Brunswick, New Jersey, USA.

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http://dx.doi.org/10.1096/fj.10-180166DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3114525PMC
July 2011

Regulation of Fertility by the p53 Family Members.

Genes Cancer 2011 Apr;2(4):420-30

Department of Pediatrics, Cancer Institute of New Jersey, University of Medicine and Dentistry of New Jersey, New Brunswick, NJ, USA.

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http://dx.doi.org/10.1177/1947601911408892DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3135638PMC
April 2011

Tumor suppressor p53 meets microRNAs.

J Mol Cell Biol 2011 Feb;3(1):44-50

Department of Radiation Oncology, Cancer Institute of New Jersey, University of Medicine and Dentistry of New Jersey, New Brunswick, NJ 08903, USA.

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http://dx.doi.org/10.1093/jmcb/mjq040DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3030969PMC
February 2011

The origins and evolution of the p53 family of genes.

Cold Spring Harb Perspect Biol 2010 Jun 16;2(6):a001198. Epub 2009 Dec 16.

Institute for Advanced Study, Princeton, NJ 08540, USA.

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http://cshperspectives.cshlp.org/lookup/doi/10.1101/cshpersp
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http://dx.doi.org/10.1101/cshperspect.a001198DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2869528PMC
June 2010

Negative regulation of tumor suppressor p53 by microRNA miR-504.

Mol Cell 2010 Jun;38(5):689-99

Cancer Institute of New Jersey, University of Medicine and Dentistry of New Jersey, New Brunswick, NJ 08903, USA.

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http://dx.doi.org/10.1016/j.molcel.2010.05.027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2900922PMC
June 2010

Differential levels of transcription of p53-regulated genes by the arginine/proline polymorphism: p53 with arginine at codon 72 favors apoptosis.

FASEB J 2010 May 17;24(5):1347-53. Epub 2009 Dec 17.

Cancer Institute of New Jersey, University of Medicine and Dentistry of New Jersey, New Brunswick, New Jersey, USA.

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http://www.fasebj.org/doi/10.1096/fj.09-146001
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http://dx.doi.org/10.1096/fj.09-146001DOI Listing
May 2010

Glutaminase 2, a novel p53 target gene regulating energy metabolism and antioxidant function.

Proc Natl Acad Sci U S A 2010 Apr 8;107(16):7455-60. Epub 2010 Apr 8.

Cancer Institute of New Jersey, University of Medicine and Dentistry of New Jersey, New Brunswick, NJ 08903, USA.

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http://dx.doi.org/10.1073/pnas.1001006107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2867677PMC
April 2010

The role of p53 gene family in reproduction.

Authors:
Wenwei Hu

Cold Spring Harb Perspect Biol 2009 Dec 28;1(6):a001073. Epub 2009 Oct 28.

Cancer Institute of New Jersey, University of Medicine and Dentistry of New Jersey, New Brunswick, New Jersey 08903, USA.

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http://dx.doi.org/10.1101/cshperspect.a001073DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2882126PMC
December 2009

A polymorphic variant in human MDM4 associates with accelerated age of onset of estrogen receptor negative breast cancer.

Carcinogenesis 2009 Nov 16;30(11):1910-5. Epub 2009 Sep 16.

Department of Medicine-Division of Medical Oncology, The Cancer Institute of New Jersey, University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School, New Brunswick, NJ 08901, USA.

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http://dx.doi.org/10.1093/carcin/bgp224DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3895963PMC
November 2009

The regulation of human reproduction by p53 and its pathway.

Cell Cycle 2009 Nov;8(22):3621-2

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http://dx.doi.org/10.4161/cc.8.22.9938DOI Listing
November 2009

Single-nucleotide polymorphisms in the p53 pathway regulate fertility in humans.

Proc Natl Acad Sci U S A 2009 Jun 22;106(24):9761-6. Epub 2009 May 22.

Center for Reproductive Medicine and Infertility, Weill Cornell Medical College, New York, NY 10021, USA.

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http://dx.doi.org/10.1073/pnas.0904280106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2700980PMC
June 2009

Winter temperature and UV are tightly linked to genetic changes in the p53 tumor suppressor pathway in Eastern Asia.

Am J Hum Genet 2009 Apr 2;84(4):534-41. Epub 2009 Apr 2.

State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology and Kunming Primate Research Centre, Chinese Academy of Sciences, Kunming 650223, PR China.

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http://dx.doi.org/10.1016/j.ajhg.2009.03.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2667983PMC
April 2009

[Reconstituting turkey herpesvirus with bacterial artificial chromosome clones].

Wei Sheng Wu Xue Bao 2008 Jun;48(6):811-7

Division of Avian Infectious Diseases, National Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute the Chinese Academy of Agricultural Sciences, Harbin 150001, China.

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June 2008

The tumor suppressor p53: cancer and aging.

Cell Cycle 2008 Apr 23;7(7):842-7. Epub 2008 Jan 23.

Cancer Institute of New Jersey, University of Medicine and Dentistry of New Jersey, New Brunswick, New Jersey, USA.

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http://www.tandfonline.com/doi/abs/10.4161/cc.7.7.5657
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April 2008

p53: a new player in reproduction.

Cell Cycle 2008 Apr 23;7(7):848-52. Epub 2008 Jan 23.

Cancer Institute of New Jersey, University of Medicine and Dentistry of New Jersey, New Brunswick, New Jersey, USA.

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http://dx.doi.org/10.4161/cc.7.7.5658DOI Listing
April 2008

Reconstructing signal transduction pathways: challenges and opportunities.

Ann N Y Acad Sci 2007 Dec 12;1115:32-50. Epub 2007 Oct 12.

School of Natural Sciences, Institute for Advanced Study, Einstein Drive, Princeton, NJ 08540-0631, USA.

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http://dx.doi.org/10.1196/annals.1407.018DOI Listing
December 2007

p53 regulates maternal reproduction through LIF.

Nature 2007 Nov;450(7170):721-4

Cancer Institute of New Jersey, University of Medicine and Dentistry of New Jersey, New Brunswick, New Jersey 08903, USA.

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http://dx.doi.org/10.1038/nature05993DOI Listing
November 2007

Declining p53 function in the aging process: a possible mechanism for the increased tumor incidence in older populations.

Proc Natl Acad Sci U S A 2007 Oct 5;104(42):16633-8. Epub 2007 Oct 5.

Cancer Institute of New Jersey, University of Medicine and Dentistry of New Jersey, New Brunswick, NJ 08903, USA.

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http://www.pnas.org/cgi/doi/10.1073/pnas.0708043104
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http://dx.doi.org/10.1073/pnas.0708043104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2034252PMC
October 2007

A single nucleotide polymorphism in the MDM2 gene disrupts the oscillation of p53 and MDM2 levels in cells.

Cancer Res 2007 Mar;67(6):2757-65

Cancer Institute of New Jersey, University of Medicine and Dentistry of New Jersey, New Brunswick, New Jersey, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-06-2656DOI Listing
March 2007

Malondialdehyde, a major endogenous lipid peroxidation product, sensitizes human cells to UV- and BPDE-induced killing and mutagenesis through inhibition of nucleotide excision repair.

Mutat Res 2006 Oct 26;601(1-2):125-36. Epub 2006 Jul 26.

Department of Environmental Medicine, New York University School of Medicine, Tuxedo, NY 10987, USA.

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October 2006

Acrolein is a major cigarette-related lung cancer agent: Preferential binding at p53 mutational hotspots and inhibition of DNA repair.

Proc Natl Acad Sci U S A 2006 Oct 9;103(42):15404-9. Epub 2006 Oct 9.

Department of Environmental Medicine, Pathology, and Medicine, New York University School of Medicine, Tuxedo, NY 10987, USA.

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http://www.pnas.org/cgi/doi/10.1073/pnas.0607031103
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http://dx.doi.org/10.1073/pnas.0607031103DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1592536PMC
October 2006

Detection of functional single-nucleotide polymorphisms that affect apoptosis.

Proc Natl Acad Sci U S A 2005 Nov 31;102(45):16297-302. Epub 2005 Oct 31.

Cancer Institute of New Jersey, Robert Wood Johnson Medical School/University of Medicine and Dentistry of New Jersey, 195 Little Albany Street, New Brunswick, NJ 08903, USA.

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http://dx.doi.org/10.1073/pnas.0508390102DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1283473PMC
November 2005

A plausible model for the digital response of p53 to DNA damage.

Proc Natl Acad Sci U S A 2005 Oct 26;102(40):14266-71. Epub 2005 Sep 26.

IBM Thomas J. Watson Research Center, Yorktown Heights, NY 10598, USA.

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http://dx.doi.org/10.1073/pnas.0501352102DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1242279PMC
October 2005

A single nucleotide polymorphism in the MDM2 gene: from a molecular and cellular explanation to clinical effect.

Cancer Res 2005 Jul;65(13):5481-4

The Cancer Institute of New Jersey, Robert Wood Johnson Medical School, New Brunswick, New Jersey, USA.

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http://cancerres.aacrjournals.org/lookup/doi/10.1158/0008-54
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July 2005

MDM2 is a central node in the p53 pathway: 12 years and counting.

Curr Cancer Drug Targets 2005 Feb;5(1):3-8

School of Natural Sciences, Institute for Advanced Study, Princeton, NJ 08540, USA.

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http://dx.doi.org/10.2174/1568009053332627DOI Listing
February 2005

Chromium(VI) enhances (+/-)-anti-7beta,8alpha-dihydroxy-9alpha,10alpha-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene-induced cytotoxicity and mutagenicity in mammalian cells through its inhibitory effect on nucleotide excision repair.

Biochemistry 2004 Nov;43(44):14282-9

Department of Environmental Medicine, Pathology, and Medicine, New York University School of Medicine, Tuxedo, New York 10987, USA.

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http://dx.doi.org/10.1021/bi048560oDOI Listing
November 2004

Trans-4-hydroxy-2-nonenal inhibits nucleotide excision repair in human cells: a possible mechanism for lipid peroxidation-induced carcinogenesis.

Proc Natl Acad Sci U S A 2004 Jun;101(23):8598-602

Department of Environmental Medicine, New York University School of Medicine, Tuxedo, NY 10987, USA.

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http://dx.doi.org/10.1073/pnas.0402794101DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC423240PMC
June 2004

Nickel (II) enhances benzo[a]pyrene diol epoxide-induced mutagenesis through inhibition of nucleotide excision repair in human cells: a possible mechanism for nickel (II)-induced carcinogenesis.

Carcinogenesis 2004 Mar 6;25(3):455-62. Epub 2003 Nov 6.

Department of Environmental Medicine, New York University School of Medicine, Tuxedo, NY 10987, USA.

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https://academic.oup.com/carcin/article-lookup/doi/10.1093/c
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http://dx.doi.org/10.1093/carcin/bgh012DOI Listing
March 2004

Effects of genomic context and chromatin structure on transcription-coupled and global genomic repair in mammalian cells.

Nucleic Acids Res 2003 Oct;31(20):5897-906

Department of Environmental Medicine, New York University School of Medicine, Tuxedo, NY 10987, USA and. Department of Biological Sciences, Columbia University, New York, NY 10027, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC219485PMC
http://dx.doi.org/10.1093/nar/gkg808DOI Listing
October 2003

Formation of trans-4-hydroxy-2-nonenal- and other enal-derived cyclic DNA adducts from omega-3 and omega-6 polyunsaturated fatty acids and their roles in DNA repair and human p53 gene mutation.

Mutat Res 2003 Oct;531(1-2):25-36

Division of Carcinogenesis and Molecular Epidemiology, Institute for Cancer Prevention, American Health Foundation Cancer Center, Valhalla, NY 10595, USA.

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http://dx.doi.org/10.1016/j.mrfmmm.2003.07.001DOI Listing
October 2003

Preferential carcinogen-DNA adduct formation at codons 12 and 14 in the human K-ras gene and their possible mechanisms.

Biochemistry 2003 Aug;42(33):10012-23

Department of Environmental Medicine, New York University School of Medicine, Tuxedo, New York 10987, USA.

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http://pubs.acs.org/doi/abs/10.1021/bi034631s
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August 2003

Mutational spectrum and genotoxicity of the major lipid peroxidation product, trans-4-hydroxy-2-nonenal, induced DNA adducts in nucleotide excision repair-proficient and -deficient human cells.

Biochemistry 2003 Jul;42(25):7848-54

Department of Environmental Medicine, New York University School of Medicine, Tuxedo, New York 10987, USA.

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http://pubs.acs.org/doi/abs/10.1021/bi034431g
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July 2003

Gene expression of primary human bronchial epithelial cells in response to coal dusts with different prevalence of coal workers' pneumoconiosis.

J Toxicol Environ Health A 2003 Jul;66(13):1249-65

Department of Environmental Medicine, New York University School of Medicine, New York 10016, USA.

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http://dx.doi.org/10.1080/15287390306411DOI Listing
July 2003

Chromium(VI) exposure enhances polycyclic aromatic hydrocarbon-DNA binding at the p53 gene in human lung cells.

Carcinogenesis 2003 Apr;24(4):771-8

Department of Environmental Medicine, New York University School of Medicine, Tuxedo 10987, USA.

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http://dx.doi.org/10.1093/carcin/bgg012DOI Listing
April 2003